THE EFFECT OF GLUTAMINE SUPLEMENTATION TO me eee me Cole RoC SS AND DIARRHEA DURATION IN CHILDREN WITH Pet dT Te nee CCU RL CREEL Lm cur MU) Department of Child Health, Faculty of Medicine/ Dr. M Djamil Hospital, Andalas University, Padang, Indonesia Glutamine is a nonessential amino acid and become “conditionally-essensial" in diarrhea. Diarrhea can cause immunological and histological changes on the colon. One of the age (month) 14,35(805,92) 18,63(SD13,7) immunological component is secretory Table 1. Demographic data of subject Intervension group Control group N__ Mean (SD) Mean (SD) immunoglobulin A (sIgA). SIgA is largely a A A produced on the mucousal surface and give 8 5 protection to the intestinal mucosa from any pea antigen. SIgA deficiency will make the intestinal See mucosal vulnerable to any pathogenic bacteria Undemourished 13 8 and toxin. Welnourished ie 8 Dehidration Sy — Without 2 To determine the effect of glutamine Mike megeratei8 supplementation on sigA and duration of diarthea in children with acute diarrhea. Table 2. The effect of glutamine supplementation on fecal sIgA ‘An experimental study was conducted from sigh Intervention 1,90 003 16,450.92 March to December 2015 in pediatric wards of Gates aie ce WES Dr. M. Djamil Hospital and some health centers sig intervention 7.11 0,16 «28,820,480 in Padang. Subject were randomly devided into post. Control 3.64 0,80 40,66, two groups, which intervention group recieve ai, intervention 239 692 ~—«1544_—=Ct«é glutamin (n=20) dan control group (n=16). sig Control. 0.28 «14,89 «33,02 Statistical test using Mann withney. i Table 3. The effect of glutamin on duration of diarrhea Intervention Control P value The median level of slgA post in intervention Mean(SD) Mean(SD) group was 7,11 g/dl (max 23,82 g/dl and min 0,16 yig/dl). The median level of sigA post in Duration 71,00(SD18,31) 97,28(SD25,66) 0,029 control group was 3,64 g/dl (max 40,66 g/dl (hour) and min 0,40 jig/dl). There wa no statistically significant difference in sigA levels after 7 days Sfobsonation eiherinte meventen ote [TTS control group. The duration of diarrhea in the intervention group 71.00 ( $D18,31 ) hours Glutamine significantly decreases of acute diarrhea. shorter than the control group 97. 28 (SD25, 68) Glutamine increases SigA level, not statistically hours and the difference is significant. significant