Humankind has been in the business of discovering drugs for thousands of years.

At
present, small-molecule drug design is based on specific macromolecular receptors as
targets for inhibition or modulation. To this end, a number of clever approaches have
evolved over time: computer-aided techniques including structure-activity
relationships and synthesis, high-throughput screening, quantitative structure-activity
relationships, hypotheses derived from ligand- and/or structure-based information and
focused library approaches. In recent years, several alternative strategies have
appeared in the form of the emerging paradigms of polypharmacology, systems
biology and personalized medicine. These innovations point to key challenges and
breakthroughs likely to affect the future of small-molecule drug discovery.
Every molecule that you make during a drug discovery program is a molecule that has
never been made in the universe ever you are completely and entirely in no man’s
land when you are doing this work.
Large molecules cannot get inside the cell so large molecules can influence diseases
by interacting with things that are on the surface of the cell, small molecules can get
inside the cell we can interact with the machinery inside of the cells we can disrupt
certain process within the cells
The challenge of drug discovery is finding that molecule and it’s often a needle in a
hast stack and we will make thousands of molecules in order to find the right one
which has exactly the same properties that we were searching for and it’s a very
iterative process you test them in your biological asses you look at their metabolism
properties and then based on that you go back and make the next molecule that you
think will be best for your study
90% of the experiments that you run don’t work, a successful scientist is the one that
spends his time talking about how to make it work because 10% of the time it does
but you have to run all ten experiments to figure out which one is the one that will
ultimately help you refine your hypothesis
Vue les caracteristique uniques du C6’CH3) new molecule that could eventually
have applications in medicine, food science and other fields
La majorities des polymers crees au cours de l’histoire en etait decouvert par le
hasard When research chemist Jeannette García found a candy-size
lump of white material in a flask she had recently used, she had no
idea what she had created. The material stuck firmly to the glass, so
she used a hammer to break it free. But when she turned the hammer
on the material itself, it refused to crack. It was in that moment that
she realized that she made a new polymere
But what if we already know what we are aiming for? Knowing the
exact form and properties of the molecule that we are manuplating
can give us astonishing results Vue les caracteristique uniques du C6’CH3) et
sa forme crystalline cette molecule sera un sujet d’etude parfait pour la creation de
nouvelle polymere in the near future
Global demand for durable, recyclable plastics is expected to soon
increase. By 2015, for example, both Europe and Japan will require
that 95 percent of car parts produced there be recyclable.
But she believes that the new thermoset could also eventually extend
into a range of applications—anticorrosive and antimicrobial
coatings, drug delivery, adhesives, 3-D printing, water purification,
among others.
Humans have been creating synthetic polymers for the better part of a century,
and they can now be found in everything from your steering wheel and favorite
polyester suit to your computer and airplanes. But new polymer-forming chemical
reactions like this one are extremely rare.

"Most [polymer] discoveries were made between 1930 and 1950," Garcia
told Mashable.

Polymers are essentially macromolecues made up of 10,000 or more atoms and

they occur in nature (rubber) and have been synthesized in the lab (Polystyrene).