Waktu (jam) Ct (ug/ml) LnCp

0.25 8.21 2.1053529235

0.5 7.87 2.0630580624 2.5
1 7.23 1.9782390362 2 f(x) = - 0.17028
3 5.15 1.6389967147 1.5 R² = 0.9999994
6 3.09 1.1281710909

Concentration
1
12 1.11 0.1043600153
0.5
18 0.4 -0.9162907319
0
0 2 4 6
-0.5
Parameter Farmakokinetik Hasil -1
Ke (/jam) 0.1703
-1.5
t1/2 (jam) 4.0692894891
Ln C0 2.1487
C0 8.5737053323
Dosis i.v. (mg) 250
Vd (ml) 29.1589214126
Cl (ml/jam) 4.9657643166
AUC 50.3447171599

Persamaan Farmakonkinetik
LnCp = LnCp0 - kt
LnCp = 2,1487 - 0,1703t
 Kurva Obat Mono Kompartemen
2.5
2 f(x) = - 0.170282106x + 2.1486975613
1.5 R² = 0.9999994442
Concentration

1
Obat Mono Kompartemen
0.5 Li near (Obat Mono
Kompartemen)
0
0 2 4 6 8 10 12 14 16 18 20
-0.5
-1
LnCt = Ke.t + LnCo
-1.5

Time
Waktu (jam) Kadar Obat dalam darh (ug/ml) Ln Cp Ln C' C'
0.25 53.8 3.9852735 2.796675 16.3900591
0.5 43.3 3.7681526 2.76525 15.8830102
0.75 35 3.5553481 2.733825 15.3916476
1 29.1 3.3707382 - -
1.5 21.2 3.0540012 - -
2 17 2.8332133 - -
3 12.6 2.5336968 - -
4 10.5 2.3513753 - -
5 9 2.1972246 - -
6 8 2.0794415 - -
7 7 1.9459101 - -

Persamaan Parameter Hasil

α 1.292
y = -1,292x + 3,949 Ln A 3.949
A 51.8834574
y = bx + a β 0.1257
y= -0,1257x + 2,8281 Ln B 2.8281
B 16.913295

Persamaan Farmakokinetik
LnCp = (LnA - at) + (LnB - at)
LnCp = (3,949 - 1,292t) + (2,8281 - 0,1257t)
 Cr Ln Cr
37.4099409 3.621936 Kurva Obat Multi Distribusi
27.4169898 3.311163 4.5
19.6083524 2.975956
- - 4
- - 3.5 1.2919617014x + 3.6885509409
f(x) = - 0.2870866177x 3.9489991742
- - 0.9995233382
R² = 0.8978245159
3
- - Obat Multi Kom
- - Linea r (Obat M
Concentration 2.5
Post Di stribus i
- -
2 f(x) = - 0.1256572141x + 2.8281353742 Linea r (Post Di
- - R² = 0.9986927871 Fas e Distribus
- - 1.5 Linea r (Fa s e D

0.5

0
0 1 2 3 4 5 6 7 8

Time

Parameter Farkin K (/jam) K12 (/jam)K21 (/jam) t1/2 Vp (ml)

Rumus 0.393776 0.611496 0.4124283 5.5131265 0.7267785
tribusi

Obat Multi Kompa rtemen

Linea r (Obat Multi Kompartemen)
Post Distri bus i (Fas e El emi nas i)
2.8281353742 Linea r (Post Di stribusi (Fa s e Elemina s i))
Fas e Distribus i
Linea r (Fa s e Distri bus i )

LnCt = β.t + Ln B
8

LnCt = α.t + Ln A

AUCo (mg/ml.jam)
Cl (ml/jam)
174.7103389 0.286188