Biofilms are critical for the pathogenicity of most bacteria, with several factors and multiple

stimuli can induce biofilm formation.

These risk factors above that make it easier or influence for Biofilm-Forming
-Immune responses
-Microbiologic toxins ( Mikroorganism create a qualitative toxin, such as Alpha and Beta toxin
production )
-Pigmentation
-Patient demographics ( Patient demographics or patient data include some important points.
Receipt of antimicrobials, medications, patient’s hyigine, health care exposure, diagnoses, and
procedures can influence biofilm-formation.)
-Antibiotic Prophylaxis
-Enviromental stressor include temperature, pH, and availability of nutrients