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Nursing Pharmacology Instruct client to take one short deep breath after
each instillation and to remain position for 3-5
The seven rights of medication administration minutes.
RIGHT DRUG For oral medication:
RIGHT CLIENT Do not crush or chew enteric coated tablets.
RIGHT DOSE Many oral medications require administration with
RIGHT TIME milk or food
RIGHT ROUTE Schedule first doses of new medications on
RIGHT REASON different hours from other medications
RIGHT DOCUMENTATION For Pediatric Patients
General Principles in Drug Administration If drugs are being mixed with food or liquid, use
Whoever prepares the medication, administers and only small amount
charts it Medicine can also be given through nipples or
Consult a drug reference manual or pharmacist for droppers
information on unfamiliar drugs Toddlers: allow to choose on method of delivery-
For elderly clients: use devices like calendars, daily spoon, dropper, syringe, and allow to help
pill dispensers Position: Semi-Fowler’s or sitting
For pediatric clients, use syringe Instruct client to place tablets/ capsules at the back
Obtain assistance of parents to hold child in position of the throat and to follow with enough liquid
Assess client’s allergy Administer liquid medications after pills
Check drug’s expiry date Remain with the client until all the medications are
Read labels three times before administration taken. Check the client’s mouth
Wash hands before and after administration Check client 30-60 minutes later for effects of
Do not let the tip of the tube/dropper touch the medication.
client
Document administration on medication record and For buccal and sublingual medication
client’s response to medication. Place under the tongue (sublinggual) and between
For eye medication: cheek and gum (buccal)
Position: supine or sitting position with forehead If client’s mucous membranes are dry, offer a sip of
tilted back slightly water
Medication is administered into the conjunctival sac DRUGS
For ointments, apply from inner to outer canthus 1.Local anesthetics:
ending it with a twisting motion -blocks nerve conduction
Let the client close his eyes -metabolized by hepatic enzymes
For liquid medications, press firmly nasolacrimal -produces temporary loss of sensation and
duct for at least 30 seconds motion in a limited area of the body.
If medication temporarily affects vision, instruct E.g: Procaine (novocain),Benzocaine
client not to move until vision is clearer (americaine),mepivacaine (carbocaine)
Lift side rails and place call light within reach Nursing implications:
For ear (otic) instillation: a. force fluids
Wash ear if excess wax in noted b. keep side rail-up
Position: Side-lying, sitting, or semi-Fowler’s LIDOCAINE TOXICITY
position SLURRED SPEECH
For adults: pull auricle of ear up and back ALTERED CNS
For children: down and back (<3 years) MUSCLE TWITCHING
Instruct client to remain in position for 3-5 minutes SEIZURES
For nasal instillation 2. Non narcotic analgesics and antipyretics
Cleanse nares Aspirin
Position: Sitting with head tilted slightly backwards, -analgesia
or supine with head tilted back in hyperextended -antipyretic
position -anti-inflammatory
Hold dropper ¼ to ½ inch above nares -anti-platelet
Acetaminophen/Tylenol
-Analgesic,antipyretic
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Monitor apical pulse and blood pressure. If pulse is -increases force of myocardial contraction (+
>100 bpm, withhold the drug inotropic effect
Store in air-tight and light-resistant containers - improves blood supply to vital organs and
Monitor prothrombin time; a patient taking these kidneys, providing a diuretic effect.
hormones usually requires less anticoagulant -decreases rate of contraction (- chronotropic
OXYTOCIN effect)
Uses: -CHF,Atrial fibrillation, atrial flutter,paroxysmal
Promotion of uterine contractions atrial tachycardia.
Control of bleeding Cardiovascular Drugs
Release of milk from breast Nursing Implications:
Oxtocin-related drugs: -avoid high Na, increase K
Methergine -Antidote: digoxin immune Fab (digi-bind)
Ergonovine Hold if apical pulse:
Adverse Effects: -infants: below 90 beats
Tachycardia -children/adolescence: below 70
Water intoxication -adults: below 60 or above 120.
Uterine rupture Monitor serum digoxin levels: 0-5 to 2.0ng/ml.
Nausea and vomiting Anti anginal Drugs
Cardiovascular collapse Nitrites & Nitroglycerin
Anaphylaxis -dilates the peripheral vascular smooth muscles of
Hypertension (oxytocin-related drugs) small vessels.
Nursing Implications: -decreases cardiac pre load and after load.-
Use infusion pump for administration. Never give decreased myocardial oxygen needs
IM -dilates large coronary arteries,which helps decrease
Monitor BP, heart rate and I and O. anginal pain & hypoxia of the myocardium
Regularly monitor for uterine contractions and Anticoagulants
FHR. Heparin
Discontinue if: -blocks conversion of prothrombin to
With note of tetanic uterine contractions. thrombin and fibrinogen to fibrin
Signs of fetal distress Warfarin (coumarin)
Urinary flow is less than 30 ml/hour -blocks prothrombin synthesis
Signs of abruptio placenta and uterine rupture -takes 2-5 days –effect
For ergonovine/methergine- C/I for patients with Thrombolytic Drugs
vascular, renal and hepatic problems Streptokinase
Ophthalmic Drugs Activase, urokinase
A. Mydriatics and Cycloplegics -when use in treatment of MI, start therapy
-Atropine, Cyclogyl within 6 hours of attack.
-causes mydriasis (dilatation) and - corticosteriods -given to decrease allergic
cyloplegia, w/c paralyzes the lens and eye muscles. reaction
Nursing Implications: -Reconstitute it with normal saline or 5%
-sunglasses dextrose solution
-artificial tears -Avoid IM route
-elderly caution to atropine-IOP -Antidote: Aminocaproic acid
B. Miotics Antihypertensives
Acetylcholine (miochol) ACE INHIBITORS - CAPOTEN/CAPTOPRIL,
Carbachol (isopto carbachol) VASOTEC/ENALAPRIL,
Pilocarpine LOTENSIN/BENZAPRIL
-causes miosis (contraction) of pupils and BETA – BLOCKERS- INDERAL/PROPANOLOL,
ciliary muscles TENORMIN/ATENOLOL
-decreases IOP CALCIUM ANTAGONIST- CALAN
Cardiovascular Drugs ISOPTIN/VERAPAMIL,
Cardiac Glycosides CARDIZEM/DIALTIZEM,
Digoxin (Lanoxin) PROCARDIA/ NIFEDIPINE
Nursing Implications
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Nursing Implications:
D. Ipecac Syrup -do not crush enteric coated tablet
-irritates the GIT to induce vomiting / -take in empty stomach ,full glass of water
delaying the absorption time of toxic substances -do not give w/ antacids
-GI s/s are dose related
Nursing Implications: E. Tetracyclines
-emesis should occur w/in 20-30 min -Bactericidal
-repeat dose Nursing Implications:
-less than 10 yrs old,one dose only -avoid with pregnant women
-not given: corrosive,petroleum based or Nursing mothers, Children under 8 y/o as
cyanide drug binds to calcium in teeth & new bone growth
-lead to tooth discoloration of permanent
E. Anti gout teeth & retarded bone growth.
Allopurinol (Zyloprim) - prevents production of -Avoid taking w/ dairy products, antacids,
uric acid vitamins, minerals.
Nursing Implications: -take 1 hr before meals,2 hrs after meals.
-force fluid:2-3 liters -report diarrhea episodes
-take after meals F. Urinary-Anti-infectives
-monitor Liver function test/CBC Nitrofurantoin (Macrodantin)
-Bacteriostatic
Colchicine (Novocolchine) Nursing Implications:
-drug of choice for acute gouty attacks -monitor pulmonary ,neurologic status
-decreases the inflammatory response to -give w/ milk or meals
deposits of monosodium urate crystals -avoid crushing tablet: tooth staining
Nursing Implications: -dilute suspension
-acute attack: given 1-2 hrs until pain ceases -rinse mouth
Antimicrobials -nausea/vomiting common effect
A. Aminoglycosides: G.Vancomycin HCL (Vancocin)
Gentamicin (Garamycin) -Exhibit bactericidal & Bacteriostatic effect.
-bactericidal Nursing Implications:
Nursing Implications: -monitor renal/auditory function test
-caution with decreased renal function, -adm.IV slow 60 minutes: prevent phlebitis,
reduced hearing, dehydration,neuromuscular extravasation, red-neck syndrome ( fever, hives,
disorders rash & redness of the face)
-adequate hydration
B.Penicillin G Potassium (Pentids) H. ciprofloxacin (Cipro)
-Bactericidal -Bactericidal
Nursing Implication: Nursing Implications:
-check allergic reactions -adm. with large glass of water
-Skin test -do not give with antacids
-give oral tablet empty stomach, -give 2 hours after meals
with full glass of water I. Antitubercular Drugs
-monitor CBC, BUN, Creatinine Isoniazid (INH)
C. Cephalosporins: -Bacteriostatic, If high concentration
-Bactericidal becomes Bactericidal
Nursing Implications: Nursing Implications:
-IM: rotate sites -assess neuromuscular function
-Assess for hx.of penicillin allergy: cross allergy -give B6 pyridoxine
between cephalosporin & penicillin -empty stomach-single daily dose
-reduce dose with renal/liver problems. -with meals & divide daily dose into 3 equal
-Thrombophlebitis: long IV administration. parts: GI upset.
Report diarrhea,rash,hives,dyspnea, bleeding Ethambutol (Myambutol
D. Erythromycin: -report any s/s blurring of vision
-Bacteriostatic (unable to see red or green)
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-Caution with renal impairment Infuse 1 liter of 0.9 NACl over 8 hours using 10 gtt
factor.
.Rifampin (Rifadin, Rimactane) Infuse 500ml of .45 NaCl over 12 hours to a 3-year-
-expect orange tinged body fluids old child.
-report anorexia,nausea/vomiting, jaundice, Milliliters per Hour (ml/hr)
malaise,dark urine Formula: Volume in ml
Computations Total # of hours= ml/hr
Preparing Solutions Infuse 1000 ml Lactated Ringer’s (LR) solution
1. Liquid to Drug Solutions over 10 hour.
Determine the strength of the solution, the strength 1000 ml 10 hour = 100 ml/hr
of the drug on hand and the quantity of the solution
required Drugs ordered in Units per Hour or Milligrams per
Formula Hour
Dose = Amount of Solution Doctor’s order: mix 10,000 U heparin in 1000 ml
Strength on hand D5W; infuse 80 units per hour
Example 1000 ml : 10,000 units :x ml : 80 U/hr
You have a 100% solution of hydrogen peroxide on 10,000 units x =80,000 ml-U/hr
hand. You need a liter of 50% solution. 10,000 U 10,000 U
x= 8 ml/hr
50 X 1000 ml = 500ml milliliters per hour
100 Mix 10,000 U heparin in 1000 ml D5 W; infuse at
Solid Dose of Oral Administration 15 ml/hr. How many units of heparin are being
Physician orders patient to have 1.0 g of ampicillin. delivered per hour?
The ampicillin bottle states that each tablet in the 1000 ml : 10,000 U : : 15 ml : x U
bottle contains 0.5 g. 1000 ml X = 150,000 U-ml
2 Methods 1000 ml 1000 ml
dosage desired = 1.0 g = 2 x= 150 U
dosage on hand 0.5 g Calculation of Flow Rates
Exercise Milliliters per Hour (ml/hr)
The physician order 1000 mg of ampicillin. Formula: Volume in ml
On hand: 0.25 grams per tablet. Total # of hours= ml/hr
X= Infuse 1000 ml Lactated Ringer’s (LR) solution
Liquid Dose of Oral Administration over 10 hour.
30 ml = 1 oz 1000 ml 10 hour = 100 ml/hr
Physician orders 60 ml of a liquid medication. How NUTRITION
many ounces will be given? Food Pyramid
Physician orders 45 ml. How many ounces will be Bread, cereal, rice, pasta- 6-11
given? Fruit- 2-4
Liquid Dose of Oral Administration Vegetable- 3-5 servings
Order: 500 mg;Dose at hand: 250mg/5 ml. How Milk- 2-3 servings
many ml will be given? Meat, poultry, fish, dry beans, eggs,
Formula: D/H x Q nuts- 2-3 servings
500/250 x 5 ml= 10 ml Fats- use sparingly
Order: 250 mg; dose at hand: 125 mg/ml K Caloric Values
Order: 500 mg; dose at hand: 125 mg/ml Carbohydrates 4
Calculation of Flow Rates Protein 4
Drops/ min Lipids (Fats) 9
Formula: Vitamin B1, (Thiamine)
vol in ml x gtts (ugtts)/ml = drops/min Vitamin B2, (Riboflavin)
time in minutes Vitamin B3, also Vitamin P (Niacin)
Infuse 1000 ml Lactated Ringer’s (LR) solution Vitamin B5, (Pantothenic acid)
over 10 hour to a 40 year old male. Vitamin B6, (Pyridoxine)
1000ml x 15 gtts/min = 25 gtts/min Vitamin B7, also Vitamin H (Biotin)
10 hrs x 60 min/hr Vitamin B9, (Folic acid)
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