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AN ASIAN JOURNAL
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Accepted Article
Title: Alkyl Sulfides as Promising Sulfur Sources: Metal-Free Synthesis
of Aryl Alkyl Sulfides and Dialkyl Sulfides by Transalkylation of
Simple Sulfides with Alkyl Halides
Authors: Renhua Qiu, Ting Liu, Longzhi Zhu, Shuang-Feng Yin, Chak-
Tong Au, and Nobuaki Kambe
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Accepted Manuscript
transalkylation proceeds by an ionic mechanism via sulfonium reaction can be a convenient route for synthesizing alkyl sulfides
intermediates and it was proposed that DMAC may participate in via C–S bond cleavage. Herein, we present a site-selective
part to promote the reaction. metal-free dealkylative approach for the synthesis of aryl alkyl
and dialkyl sulfides from simple alkyl sulfides and alkyl halides
under ambient air conditions (Scheme 1d).
Alkyl sulfides have received considerable attention as
important scaffolds in natural products, [1] material chemistry,[2] Scheme 1. Site-Selective C(sp3) –S Bond Cleavage
pharmaceuticals,[3] food chemistry[4] and ligands.[5] The synthesis
of sulfides with a saturated carbon skeleton receives increasing
attention,[6] especially in pharmaceutical areas, due in part to
higher hydrophilic nature of alkyl groups than aromatic
groups.[6d-f] Conventional approaches for alkyl-sulfur bond
formation are mainly based on substitution reactions of
nucleophilic sulfur reagents such as metal sulfides, [7]
thiosulfates,[8] thiourea,[9] thiol derivatives[10] with electrophilic
alkylating reagents. The reactions of inverse polarity, i. e.
between electrophilic sulfuration reagents such as sulfenyl
halides,[11] or disulfides[12] and alkyl nucleophiles or olefins also
make convenient routes. Radical reactions also provide useful
methods for alkyl sulfide synthesis.[13] Transition metal catalysts
provide powerful tools for constructing (sp2)C–S bond
formation[14] by coupling[15] or addition reactions,[16] but their
application to (sp3)C–S bond formation is largely limited due to
the facile β-hydrogen elimination.[15d] Table 1. Optimization of Reaction Conditions[a]
[a] T. Liu, Prof. R.H. Qiu, L.Z. Zhu, Prof. S.-F. Yin, Prof. N. Kambe
State Key Laboratory of Chemo/Biosensing and Chemometrics,
College of Chemistry and Chemical Engineering
Hunan University
Changsha, 410081, Hunan Province, China [a] 1a (0.3 mmol, 1.0 equiv), 12 h, isolated yields. [b] vacuum (ca. 0.1 MPa)
E-mail: renhuaqiu@hnu.edu.cn (R.Q.). sf_yin@hnu.edu.cn (S.Y.) and 2 equiv of 2a was used.
[b] Prof. N. Kambe
Department of Applied Chemistry, Graduate School of Engineering, We examined transalkylation of thioanisole (1a) with 2-
Osaka University, Suita, Osaka, 565-0871, Japan bromobenzyl bromide (2a) to give 3aa. (Table 1) During using
E-mail: kambe@chem.eng.osaka-u.ac.jp. (N.K.) various additives and catalysts (see Supporting Information),.
[c] Prof. C.T. Au
College of Chemistry and Chemical Engineering, Hunan Institute of
Surprisingly, we found that the reaction did not require any
Engineering, Xiangtan, Hunan, China additives or catalysts. Among the solvents examined (i.e.,
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DMSO, DMF, toluene), dimethylacetamide (DMAC) was found to functionalyties such as 4-nitro (3f), 4-trifluoromethyl (3g), and 4-
give the highest yield (entries 2−4). When the loading of 2- cyano (3h) groups led to high yields, 87%, 85% (3gc, 60%), and
bromobenzyl bromide was increased from 1 to 4 equiv, the yield 84%, respectively. Benzyl halides bearing an electron-donating
of 3aa increased gradually up to 94% (entries 1, 5−7). Although group, such as 4-tert-butyl and 4-methyl, also worked well to
this reaction proceeded at lower temperatures (25 °C to 140 °C), give 3i (3ic) and 3j (3jc), albeit in somewhat lower yields, 68%
the best yield was achieved at 160 °C (entries 7−12). This (40%) and 66% (45%) respectively. Sulfides containing a
reaction was completed in 4 h at 160 °C as shown in entries 13 biphenyl (3k), naphthalene (3l), sterically hindered
to 17 (1 h, 73%; 4 h, 92%). However, in order to ensure reaction diphenylmethyl (3m) moiety were obtained in 82%, 48% and
completion, we conducted this reaction at 160 °C for 12 h 60% yield, respectively. Benzyl chlorides can also be used in
employing 1 equiv of alkylsulfide (1), 4 equiv of alkyl halide (2) place of benzyl bromides to give 3aa, g, i, j in satisfactory yields.
and DMAC as the solvent all though this study unless otherwise It is noteworthy that unactivated alkyl bromides and iodides were
stated. also successfully employed to afford the corresponding alkyl
[a] phenyl sulfides having a longer saturated carbon chain (3n−t) in
Scheme 2. Substrates Scope of Alkyl Halides
Accepted Manuscript
good yields. However, unactivated alkyl chlorides are less
reactive resulting in poor yields under identical reaction
conditions.
[a] 1 (0.3 mmol, 1.0 equiv), 12 h, isolated yields. [b] 1 h. [c] vacuum (ca. 0.1
MPa) and 2 equiv of 2a was used.
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in the order 1a(Me) > 1d(Et) > 1b(CH2Cl) > 1c(vinyl). product, 3aa was subjected to alkynylation, phenylation,
phenoxylation, and sulfonylation according to previous report,[21]
To our delight, symmetrical and unsymmetrical dialkyl sulfides
and the desired products 6, 7, 8 and 9 were obtained in 84%,
1e−l worked smoothly as the sulfur source and afforded 91%, 88% and 82% yield, respectively.
symmetrical dibenzyl sulfide 4h in moderate yields. The results
that the similar control experiments conducted for only 1 h Control experiments were performed using 1a and 2a to shed
afforded 4h in nearly the same yields suggest that structures of light on the reaction pathway (Scheme 7). When DMAC, N,N-
alkyl groups on the sulfur atom of 1e−l exert little effect on the dimethylformamide, diethylacetamide or N-acetylmorpholine
reaction rate. In these reactions using dialkyl sulfides 1e−l and were used as the solvent, 3aa was obtained in 94%, 87%, 86%
benzyl bromide 2a, alkyl benzyl sulfides were expected to be and 64%, respectively (Scheme 7a), indicating that the various
formed as the intermediates. However, only small peaks amides can be used as the solvent although DMAC gave the
assignable to such intermediates carrying only one benzyl group best yield. When the reaction was conducted using toluene as a
were detected by GC-MS analysis, indicating that the reaction non-polar solvent, the yield decreased to 50%. However,
was complete under the conditions employed. interestingly, the yield increased when DMAC was added in
When benzyl halides bearing various functional groups were small amounts. As shown in the graph in Scheme 7a, higher
yields were achieved as more DMAC was added, reaching up to
Accepted Manuscript
allowed to react with allyl methyl sulfide 1l, the corresponding
symmetrical dibenzyl sulfides (4h−n) were obtained in moderate 91% using 6 equiv. of DMAC. These results suggest that DMAC
to good yields (Scheme 4). Notably, unactivated alkyl iodides accelerates the reaction not only as the solvent but also as a
also reacted under the same reaction conditions to give 4o and reagent to promote the reaction. The evidence that the reaction
4p. Unfortunately, any attempts to prepare unsymmetrical was not quenched by addition of radical inhibitors, 2,6-di-tert-
sulfides by stepwise substitution of allyl and methyl groups of 1l butyl-4-methylphenol (BHT), (2,2,6,6-tetramethyl-piperidin-1-
failed resulting in double substitution to give 4. yl)oxidanyl (TEMPO) or 1,4-benzoquinone (1,4-BQ) ruled out
radical mechanisms (Scheme 7b). When the reaction was
Scheme 4. Double Transalkylation of Allyl(methyl)sulfane with Halides[a] conducted using different amounts of benzyl bromide 2a, the
yield increased as the amount of 2a increased (Scheme 7c),
suggesting that 2a may be involved in the rate determining step.
Scheme 6. Gram Scale Synthesis and Applications
[a] 1l (0.3 mmol, 1.0 equiv), 12 h, isolated yields. [b] 2 was 3-iodo-1-
phenylpropane. [c] 2 was 1-iodohexane.
When thioanisols bearing a hydroxyl group were subjected to
the present transalkylation with benzyl bromides or an alkyl
iodide, phenol acetylation took place concomitantly to give 5a-f
in good yields (Scheme 5). Since alkylation at the phenoxy
group was completely suppressed and acetyl group can easily Scheme 7. Control Experiments
be removed to regenerate phenoxy group,[20] the present
reaction can be applicable to preparation of phenols bearing an
alkylthiol group.
Scheme 5. Transalkylation of Thioanisole Bearing Hydroxyl Group[a]
[a] 1 (0.3 mmol, 1.0 equiv), 12 h, isolated yields. [b] 2 was 3-iodo-1-
On the basis of the results of the control experiments,[19] we
phenylpropane.
proposed possible pathways of this transalkylation (Scheme 8).
To demonstrate the potential application of this approach, we The halide 2a reacted with 1a through the nucleophilic
coupled thioanisole (1a, 5.0 mmol) with (2- substitution to produce a sulfonium intermediate I. Next, alkyl
bromobenzyl)(phenyl)sulfane, generating 3aa in 87% yield at bromide was removed to generate 3aa via a direct nucleophilic
gram scale (1.2 g, 4.3 mmol). The corresponding product 3aa
was isolated in 87% in pure form after column chromatography attack by Br anion. As a competing process, DMAC may attack
on silica gel (Scheme 6). For furthermore manipulation of the the alkyl carbon on the intermediate I to form an ammonium or
iminonium intermediate II to promote the reaction.
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Accepted Manuscript
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Accepted Manuscript
Sources: Metal-Free Synthesis of Aryl