Caused by Autoimmune disease in which Antibodies turn ON lead to

TSH receptor

graves disease toxic nodular goiter thyroiditis iodine

(most common) excess,pituitary
tumor thyroid cancers
Over fuctioning of
if nodules secrete thyroid hormone, called "toxic" thyroid glands

Hyperthroidism
Protruding
Increased T3 T4 output
eyes(exophthalmos）
Treatment

Increased
metabolic rate
thyroidectomy
Antithyroid drugs.
beta blockers-symptomatic relief
of thyrotoxicosis. drug
Iodine
unresponsive to drug therapy.
radioactive large goiters causing tracheal
compression,possible
malignancy
80% develop hypothyroidsim.
need lifelong thyroid replacement therapy.
Radioactive Iodine therapy
damages or destroys thyroid. delayed
response(2-3 months)