Fungsi esterogen

In premenopausal females, the protective effects on metabo-lism are largely attributed to

estrogens, an important class of female sex hormones. The most potent of estrogens is 17b-
estradiol (E2), which modulates food intake and energy expendi- ture through the central nervous
system [29] and also exerts direct effects on the physiology of important metabolism-regulating
tissues such as adipose, skeletal muscle, liver, pancreas as well as immune cells [30–32].
Besides regulating amount of fat, E2 also regulates the site of fat deposition as well as
inflammation and glucose and lipid homeostasis [30,32–35]. E2 specifically promotes
accumulation of subcutaneous fat and inhibits visceral fat deposition and suppresses lipogenesis
in adipose tissue, skeletal muscle, liver and pancreas [36–39]. In addition, E2 maintains glucose
homeostasis by enhancing glucose-induced insulin secre-tion from pancreatic b-cells

The primary function of estrogen which is a steroid

hormone playing the most important role in men and
women is to develop the secondary sexual characters of
woman and establish/maintain reproductive functions. The
roles of 17β-estradiol in reproductive system control uterine
and mammary growth and function. Also, 17β-estradiol has
varied effects on the brain, including reduction of neuronal
loss following stroke, increase in neuronal connectivity as
well as on many diseases and cancers.