Capsule

Content
• Definition
• Capsule type
• Excipient for hard & soft capsule: capsule & core
• Preparation & instrument for hard & soft capsule
• Evaluation capsule
 Capsule
Definition
Capsules are solid-dosage forms that are available in two types hard (two-piece) or soft (one piece),
the major component of the capsule shell is gelatin

Hard capsule Soft capsules

Excipients Gelatin (type A & B) Gelatin (mainly type B) ? why

Wetting agents/lubricants: SDS < 0.15% w/w Plasticiser (glycerol, sorbitol) 20 – 30%
Water Water
Miscellaneous excipients: Colorants, Miscellaneous excipients
opacifying agent (e.g. titanium dioxide),
flavor…
Moisture content 13-16% 5-8%

Fills Solid Liquid (→ mixture?)

Dependent method (volume) Volume?
Independent method (weight)
Advantages & disadvantages
Compare between capsules and other dosage forms
Compare between hard capsules & soft capsules
Hard capsule shell
Hard capsule filling machine
Soft capsule
Soft capsule manufacturing