What are Positive

Symptoms?
What are Negative
Symptoms?
What are Cognitive
Symptoms?
LECTURE FROM BEFORE
Appetite and Feeding Behavior
What parts of the CNS
that increase feeding?
What parts of the CNS
decrease feeding?
What regulates feeding
behavior and energy
balance?
What regulates the
activity of Arcuate
Nucleus Neurons?
What are the pathways
that drive feeding?
What is the
Homeostatic Pathway?
What is the Hedonic
Regulation Pathway?
What regulates
feeding?
Where are gut
hormone receptors
located?
What are the two
distinct populations of
neurons responsible for
appetite regulation?
What neurons inhibit
appetite?
What neurons
stimulate appetite?
Where does the ARC
send projections to?
What is the
Ventromedial Nucleus
of the Hypothalamus?
What is the Lateral
Hypothalamic Area?
What is the brain
dependent on?
What signals does the
brain rely on for
glucose utilization?
What is increased by
fasting?
What happens when
Glucose is metabolized
by glucokinase?.
Does Leptin stimulate
or inhibit feeding?
What happens when
mice are knocked out
for Leptin?
What happens when
we administer Leptin to
an obese human with
genetic leptin
deficiency?
What is obesity
associated with?
Does Ghrelin inhibit or
stimulate appetite?
Where is Ghrelin
released from?
What is the use of
Ghrelin in clinical use?
What happens when
there is reduced
Ghrelin following
Bariatric Surgery?
How does Insulin
dampen appetite?
What neurons does it
inhibit and what
neurons does it
activate?
What are the effects of
insulin on Short and
Long Term actions?
What is effect of the
resistance to insulin?
What is Amylin
secreted with?
What does Amylin do?
What happens with
Amylin in Diabetic
Patients?
Where is Peptide YY
Secreted from?
Where does Peptide YY
release to?
Where does Peptide YY
act on?
What happens when
Peptide YY act on the
receptor?
Is Peptide YY
elevated/lowered after
gastric bypass surgery?
What does GLP-1 do?
Does it
increase/decrease
feeting?
When is GLP-1 released?
What is
Cholecystokinin?
When is CCK released?
Where is CCK found?
What does
Oxyntomodulin do?
What disease states
show high levels of
Oxyntomodulin?
What happens with too
high levels of
Oxyntomodulin?
What happens when
MC3/MC4 receptors are
stimualted?
What is MC3/MC4
activated by?
What are
melanocortins released
by?
What is the result of
Melanocortins binding
to MC3/MC4?
What happens if there
is a mutation in MC4R?
What is being
developed as anti-
obesity drugs?
What is Agouti-Related
peptide?
How does Agouti-
Related Peptide
increase feeding?
What happens when
we inject AgRP to
rodents?
What inhibits AgRP
Neurons?
What activated AgRP
Neurons
What does
Neuropeptide Y do?
When is Neuropeptide
Y activated?
What stimulates
Neuropeptide Y
Neurons?
What does the
stimulation of
Neuropeptide Y
neurons lead to?
What happens when
there is a stimulation of
Neuropeptide Y?
What chemical inhibits
the expression of NPY?
What is NPY involved in
when hungry?
What happens when
we activate 5HT2C?
What happens when
we block 5HT2C?
What are the
anorexigenic agonists
at 5HT2C receptors?
What does Histamine
do?
What happens when
there is H1 blockade in
the hypothalamus?
How are histamine
neurons activated?
What is Galanin?
What are the receptors
of Galanin?
What are the Galanin
Receptors
What are the Galanin
Receptors involved in?
What do the Galanin
Receptors regulate?
What happens when
there are Galanin
Receptors in Lab
Animals?
What happens with
Orexin administration?
What does Orexin do?
What happens with
Orexin and Narcoleptic
Patients?
What is MCH?
Where are MCH
neurons located?
Where are MCH
neurons found with?
What happens when
we inject MCH?
What is Hedonic
feeding?
What happens when
there is a presence of
food?
What happens with
Hedonic Eating and
Feeding Behavior?
What are the
circuits/NTs involved
with drug addiction
similar to feeding?
What happens with the
reward system and
feeding?
What happens with our
gut microbiome and
feeding?
What is Psychobiotics?
What are the different
strategies for anti-
obesity drugs?
What is the benefit of
anti-obesity drugs
reducing food intake
How do anti-obesity
drugs modulate the
central regulation of
body weight?
How do anti-obesity
drugs increase
thermogenesis?
How do anti-obesity
drugs modulate fat
metabolism/storage?
What do traditional
appetite suppressants
do?
What are examples of
traditional appetite
suppressants?
Where do
Catecholamines act on?
What are the effects of
Catecholamines?
What are
Catecholamine Drugs?
What are the current
sympathomimetics?
What are the
traditional appetite
suppressants?
What receptors act as
appetite suppressants?
What are the drugs
that act as Appetite
Suppressants?
What is Fen-Phen?
Why was Fen-Phen
withdrawn?
What is the
mechanistm of orlistat?
What happens when
we take orlistate with
or 1 hour after meals
What is Topiramate
used for?
What happens when
we use topiramate?
What is the MOA of
topiramate?
What is Qsymia?
What does Qsymia do?
What is NE Beta-3?
What is NE-Beta -3
involved in?
How do Opiates work
with eating?
What happens when
we use Opiate
Receptor Antagonists?
What is Contrave?
How does Contrave
work?
What is the issue with
Contrave?
What does Bupropion
and Zonisamide do?
What is the MOA of
Lorcaserin?
Where is this receptor
located?
What are the benefits
of using 5HT2C
agonists?
What is the MOA of
Tesofensine?
What is the relationship
between Cigarette
Smoking and Weight?
What happens with
nicotinic receptors in
patients who smoke?
What is the effect of
cannabinoids on
feeding?
What happens when
there is is a lack of CB1?
What does leptin do
with
endocannabinoids?
What happens when
we fast and the levels
of endocannabinoids?
What is Dronabinol Oral
Formulation?
What is the MOA of
Rimonabant?
What is Rimonabant
developed as
What happens when
CB1 is inhibited?
What is the issue with
Rimonabant?

What are Behavioral

Stimulants?
What are Analeptics?
What are the
Psychoactive Drugs of
Abuse?
What are Classical
Hallucinogens?
What are Non-Classical
Hallucinogens
What are the ADHD
Stimulant Options?
What is structure of
Methylphenidate?
What is the Structure
of Amphetamine?
What is the Active
Isomer of
Amphetamine
What are
Phenylisopropylamine
Stimulants?
What happens with we
add aryl groups to the
amphetamines?
What happens when
we add Aryl
substituents into the
aromatic ring?
What happens when
add substitute amino
groups to the
amphetamines?
What happens when
we add alpha-
substituted derivatives?
What happens with B-
substituted derivatives?
How does
Amphetamine get
metabolized?
What are the non-
stimulant options for
ADHD?
What is the non-
tricyclic
phenoxyphenyl—
propylamine NE
selective reuptake
inhibitor?
What are the Selective
A2A receptor agonists?
What is the parent
structure of the
Methylxanthines?
What is the most used
CNS stimulant of the
Methylxanthine class?
What is the structure of
Theophylline
What is the structure of
Theobromine?
What happens with
CNS stimulants and the
phosphodiesterase
activity?
What is the structure of
Nicotine?
What is the mechanism
of Nicotine?
What is Khat?
What are
characteristics of Khat?
What are the appetite Orlistat
suppressants? Lorcaserin
Phentermine-Topiramate
Topiramate
Naltrexone-Bupropion
Bupropion
Naloxone, Naltrexone
Liraglutide
What is the MOA of
Orlistat?
What is the MOA of
Lorcaserin?
What is the MOA of
Phentermine
Topiramate?
What is the MOA of
Topiramate?
What is the MOA of
Naltrexone-Bupropion?
What is the MOA of
Bupropion?
What is the effect of
Naltrexone?
What is the effect of
Naloxone?
What is the effect of
Liraglutide?
What are the Appetite Dronabinol
Stimulants? Megestrol
Oxandrolone
What is the MOA of
Dronabinol?
What is the MOA of
Megestrol Acetate?
What is the MOA of
Oxandrolone?

How do we diagnose
Anorexia nervosa?
What are the severity
specifications of
Anorexia Nervosa?
What are the
Psychiatric Symptoms
of AN