Online Application Number: C3254747

Clara Sze-man Tang

Email: claratsm@gmail.com

WORKING EXPERIENCE
Oct 2015 – present Research Assistant Professor
Department of Surgery, The University of Hong Kong, Hong Kong
 Assess genetic screening of medically actionable genetic variants using
genome sequencing
 Evaluate clinical utility of expanded carrier screening and newborn
genetic testing of metabolic disorders by genome sequencing
 Analyze genetic and genomic data to detect rare variants causal to or
associated with rare congenital disorders, including colonic
aganglionosis
 Supervise postgraduate students on bioinformatics tools development
Oct 2012 – Oct 2015 Postdoctoral Fellow
Department of Psychiatry, The University of Hong Kong, Hong Kong
 Conduct research on genetic risk prediction using polygenic risk score
 Detect lipid-associated variants in relation to coronary artery disease
Sep 2010 – Sep 2012 Research Officer
Genetic Epidemiology, Queensland Institute of Medical Research, Australia
 Conduct research on asthma genetics
 Develop bioinformatics and genetic analysis tools
Jan – July 2010 Research Assistant
Department of Surgery, The University of Hong Kong, Hong Kong
 Analyze genetic data to detect copy number variants associated with
rare congenital disorders
Sep – Dec 2006 Research Assistant
Department of Medicine, The University of Hong Kong, Hong Kong
 Perform cell culture and epigenetic assays
EDUCATION
- The University of Hong Kong, Hong Kong
Apr 2010 Ph.D. Statistical genetics
Aug 2006 M.Phil. Bioinformatics
Aug 2004 B.Sc. in Bioinformatics (First Class Honors, Dean’s List)

GRANT (Principal investigator)

Project Title Project Code Funding Source Amount (HK$) Funding year

Identification and functional 04151966 HMRF 332,537 2016/2017

characterization of Hirschsprung disease
susceptibility genes on chromosome 21
 Online Application Number: C3254747

Project Title Project Code Funding Source Amount (HK$) Funding year

A trans-ethnic meta-analysis of genome- 01121796 HMRF 78,800 2013/2014

wide association studies for
Hirschsprung disease

HONORS AND AWARDS

2019 Faculty of Medicine research output prize (2018-2019)
"Exome chip meta-analysis identifies novel loci and East Asian-specific coding
variants contributing to lipid levels and coronary artery disease”
in Nature Genetics, 49(12):1722
by Tang CS, Cheung CYY, Cherny SS, Lam KSL, Tse HF and Sham PC
2018 Travel award for the 5th symposium of the Enteric Nervous System (Boston, USA)
2016 Reviewers’ Choice Abstract for the 66 Annual Meeting of the American Society of
Human Genetics (Vancouver, Canada)
2012 Young Investigator Travel Award for the 3rd International Symposium on
Development of the Enteric Nervous System (Hong Kong)
2010 Outstanding Research Postgraduate Student of The University of Hong Kong
2008 Best Poster Award for the 6th Asia Pacific Bioinformatics Conference (Kyoto, Japan)
2005 Outstanding Free Paper Award for the 3rd Hong Kong Medical Genetics Conference

PUBLICATIONS
 35 conference papers (7 presented orally)
 43 publications (17 as first author, 1 as corresponding author)
Google Scholar Scopus (ID: 35764635500)
H-index 20 16
Number of citations 1488 1027

Selected journal articles († co-first authors; *corresponding authors)

(Citation(C) is based on Scopus; Impact factor(IF) is based on JCR Science Edition 2017)
No. Publication IF C
1 Tang CS†, Li P† et al. (2018) Identification of genes associated with Hirschsprung 20.77 1
disease, based on whole genome sequence analysis, and potential effects on enteric
nervous system. Gastroenterology, 155(6):1908-1922.
2 Tang CS* et al. (2018) Actionable secondary findings from whole-genome 3.93 7
sequencing of 954 East Asians: ethnic similarities and differences. Hum Genet,
137(1), 31-37.
3 Mak TSH, Lee YK, Tang CS et al. (2018) Coverage and diagnostic yield of Whole 4.12 1
Exome Sequencing for the Evaluation of Cases with Dilated and Hypertrophic
Cardiomyopathy. Sci Rep, 18;8(1):10846.
 Online Application Number: C3254747

No. Publication IF C
4 Lu X, Peloso GM, Liu DJ, Wu Y, Zhang H, Zhou W, Li J, Tang CS et al, (2017) 27.13 23
Exome chip meta-analysis identifies novel loci and East Asian-specific coding
variants contributing to lipid levels and coronary artery disease. Nat Genet,
49(12):1722.
5 Tang CS†, Zhang H†, Cheung CYY†, Xu M† et al. (2015) Exome-wide association 12.35 29
analysis reveals novel coding sequence variants associated with lipid traits in
Chinese. Nat Commun, 6:10206.
6 Tang CS and Ferreira MAR (2012) A gene-based test of association using canonical 5.48 55
correlation analysis. Bioinformatics, 28(6):845-50.
7 Garcia-Barceló MM†, Tang CS† et al. (2009) Genome-wide association study 9.50 145
identifies NRG1 as a susceptibility locus for Hirschsprung's disease. Proc Natl Acad
Sci U S A, 106(8): 2694-9.

INVITED LECTURES AND WORKSHOP

 Invited lecture at Second International Summit on Human Genome Editing co-organized by the
Academy of Sciences of Hong Kong, The Royal Society, U.S. National Academy of Sciences and U.S.
National Academy of Medicine (2018)
 Teacher for C3BI Hands-on Next Generation Sequencing course by the University of Hong Kong and
the Institut Pasteur, Paris (2017)
 Invited lecture for 基因醫學解碼 II - 對症下藥: 膽固醇的好與壞 by the University of Hong Kong
(2016)
 Invited lecture at Hospital Authority commission training workshop, Clinical Genetics – from bed side
to bench side and back to bed side, “Complex disease with SNPs as risk contributors” (2015)
 Junior faculty member of International Workshop on Statistical Methodology for Human Genomic
Studies at Boulder, Colorado, USA (2011, 2013 and 2015)
 Invited speaker for Genetic Testing: from Virus to Human by Chinese Academy of Medical Science,
Beijing, China (2015)
 Speaker/Organizer for Next Generation Sequencing (NGS) Workshop by Centre for Genomic Sciences,
The University of Hong Kong (2014 and 2015)

PRESS CONFERENCE
 Presentation on “HKU and international collaborative research teams discover novel genetic markers
for blood lipids and coronary artery disease” (Nov 2017)
 Presentation on “HKU leads the first Chinese exome-wide genetic study on blood lipids and coronary
artery disease” (Dec 2015)
 Presentation on “HKU scientists discover that DNA changes in the Neuregulin-1 (NRG1) gene
increase the risk of Hirschsprung Disease” (March 2009)

REFENERCE
Pak C Sham, M.D., Ph.D.
Director
Centre for Genomic Sciences,
6/F HKJCBIR,
The University of Hong Kong,
5 Sassoon Road, Pokfulam.
Office: (852) 2255 4486
Fax: (852) 2855 1345
Email: pcsham@hkucc.hku.hk
Online Application Number: C3254747
Maria- Mercedes Garcia-Barceló, Ph.D.
Associate Professor
Department of Surgery,
1/F HKJCBIR,
The University of Hong Kong,
5 Sassoon Road, Pokfulam,
Office: (852) 2831 5073
Fax: (852) 2819 9621
Email: mmgarcia@hkucc.hku.hk