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Cardiopulmonary Physical Therapy 3E PDF
Cardiopulmonary Physical Therapy 3E PDF
CARDIOPULMONARY
PHYSICAL THERAPY
THIRD EDITION
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PRINCIPLES AND PRACTICE OF
CARDIOPULMONARY
PHYSICAL THERAPY
THIRD EDITION
Edited by:
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Region 7
Northwestern University
Chicago, IJlinois
Committed to Excellence
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Associate Professor
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THIRD EDITION
96 97 98 99 00 / 9 8 7 6 5 4 3 2 1
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CONTRIBUTORS
Michael Wade Baskin, PT, RRT Anne Mejia Downs, PT, CCS
OwnerlExecutive Director Department of Physical and Occupational Therapy
GT Physical Therapy and Rehabilitation Instructor, Division of Physical Therapy
West Point, Mississippi Department of Medical Allied Health Professions
School of Medicine
Jean K. Berry, PhD, RN University of North Carolina
Senior Research Specialist Chapel Hill, North Carolina
Medical-Surgical Nursing
University of Illinois at Chicago Willy E. Hammon, BSe, PT
Chicago, Illinois Chief of Rehabilitative Services
The University Hospitals
Gary Brooks, MS, PT, CCS Special Instructor in Physical Therapy
Associate Professor College of Health
Health and Rehabilitation Sciences Clinical Instructor, College of Nursing
The Sage Colleges University of Oklahoma Health Sciences Center
Troy, New York Oklahoma City, Oklahoma
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vi Preface
ArthurV. PhD
Associate Professor
of
Susan K. MS, PT Rush Medical
Rehabilitation T herapy Services Illinois
Henry Ford Hospital
Detroit, Michigan Elizabeth J. Protas,PhD, PT, FACSM
Assistant Dean and Professor
Mary lnaSS l" School of Therapy
President, Physical
Texas Woman's University
Illinois
Houston, Texas
in Michael MD,
Northwestern University Assistant Professor of Medicine
Illinois Rush Medical
'-''''vU,,",V, Illinois
Mary Mathews, BS, RN, CCRN,RRT
Neonatal and Pediatrics Chest MA,PT
Coordinator Assistant Professor
Care Services Physical Program
Luke's Medical Center of Colorado Health Sciences Center
Denver, Colorado
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To our students
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CONTEMPORARY DEFINITION OF
CARDIOPULMONARY
PHYSICAL THERAPY
culation,
ix
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FOREWORD
Donna Frownfelter and Elizabeth Dean have succeeded in creating a unique set of re
sources for students and clinicians. The importance of the oxygen transport mecha
nism is woven throughout this text and accompanying case study book, Clinical Case
Study Guide. The disruption of the mechanism can create cardiopulmonary dysfunc
tion and can result in reduced function, reduced functional work capacity, and death.
A comprehensive understanding of oxygen transport and the factors that determine
and influence it is therefore essential in order to assess the deficits of the mechanism
and determine treatment interventions.
The third edition of Principles and Practice of Cardiopulmonary Physical Therapy
is not simply a new edition of the former, Chest Physical Therapy and Pulmonary Re
habilitation. It is a totally new textbook, encompassing both the cardiac and pul
monary systems in health and dysfunction. The two previous editions have been
praised for their clinical relevance. The new books go a long way to support the state
of the art clinical practice with documented scientific literature.
The authors have many years of experience teaching undergraduate students as well
as consulting and teaching in professional postgraduate courses. These books have
been written in response to questions and concerns raised by students and clinicians.
This is the only text in which Mary Massery has published her work on neuropul
monary rehabilitation. Several chapters emphasize positioning for respiratory success
and ventilatory strategies to improve rehabilitation potential.
The books are very user-friendly. Each chapter of the text has key terms and questions
for discussion to help the reader focus on the important concepts presented in the chapter.
The combination of the text and case study guide will be an asset in teaching cardiopul
monary physical therapy. However, either book can be effectively used independently of
the other. The case study guide can be of assistance to physical therapists in helping them
focus on patient evaluation, cardiopulmonary dysfunction, and treatment approaches. I
applaud the authors for these new books and would highly recommend them for stu
dents and clinicians.
xi
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PREFACE
The work that has gone into this third edition has resulted in a completely new book!
When we first discussed the possibilities of a new edition, we knew it would be a total
change from Chest Physical Therapy and Pulmonary Rehabilitation. We wanted to
present a new approach, not just a revision. Elizabeth's research and study of oxygen
transport mechanisms in relation to patient treatment highlighted this concept as the
primary thread that would pull the new book together. The cardiopulmonary system
must be viewed as a whole, interacting with other body systems for optimal function.
Therapy interventions must incorporate cardiopulmonary goals as well as neuromus
cuiar and musculoskeletal goals for patients to reach maximal rehabilitation potential.
We have attempted to pull together physiological as well as clinical data to meet
the changing needs of health care to provide objective documentation for our interven
tions. Yet we were diligent in maintaining a text aimed at the undergraduate student or
practicing therapist with minimal background in cardiopulmonary physical therapy.
To that end we have tried to keep the material readable and very user-friendly. Our
hope is that virtually any question that may arise about treating a patient with car
diopulmonary dysfunction would have some answers in this book.
We both teach undergraduate physical therapy students and thank them for their
input, questions, and concerns about patients with cardiopulmonary dysfunction who
have helped us focus this text to meet students' needs. In addition, through our contin
uing education seminars with postgraduate physical therapists, we have been chal
lenged to apply the concepts in light of the changing health care scene. How can we be
most effective and scientifically correct in choosing treatment techniques that have
demonstrated improvement in the oxygen transport mechanism and patient function?
We always learn when we teach, and we hope to share that learning with others
through this text.
We are excited about being able to present an accompanying text, Clinical Case
Study Guide. We are attempting to show the physiological principles presented in our
text, by identifying real-life case studies that physical therapists deal with every day in
their practice. Our hope is that this will be used widely in teaching physical therapy
students and will facilitate their understanding of how to effectively integrate car
diopulmonary concepts in each of their patients, not just in patients with a primary
cardiopulmonary diagnosis.
To our knowledge, this is the first international book written dealing with car
diopulmonary physical therapy. It is a blend of physiology and international ap
proaches to the patient with cardiopulmonary dysfunction. We have had the privilege
of teaching and consulting internationally and have tried to make this text applicable
to all therapists regardless of their situation and the degree of sophisticated equipment.
xiii
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xiv Preface
Donna Frownfelter
Elizabeth Dean
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ACKNOWLEDGMENTS
There are so many people that I want to thank and acknowledge for their support and
contributions to this book. First, my family, for their understanding and support dur
ing stressful deadlines and crunch spots. My husband David has been there for me
since I went to physical therapy school and has always encouraged me to do what my
vision led me to do. My three teenagers, Lauren, Daniel, and Kristin, have helped
keep my life on track and grounded in the reality of daily life while taking time to
"smell the roses." You are special gifts to me, and I love you.
To my students, I thank you for your questions, concerns, and wonderings about
what this cardiopulmonary stuff really means to your patients. You wonder if you can
really be a better therapist because you take these things into account in evaluation
and treatment. Please remember the difference between ordinary and extraordinary is
just that little "extra." I believe that is what incorporating cardiopulmonary attention
does; it adds the little extra. Be an extraordinary therapist, no matter what the health
care environment.
To the contributing authors, I thank you for your time and significant effort in
bringing together the literature and clinical aspects of cardiopulmonary physical ther
apy. Your dedication to this project has made it much more than Elizabeth and I
could have done alone. You know how important it is to convey the message of treat
ing the whole patient and helping them reach his or her potential.
To my colleague and soul mate Mary Masse!)/, who I have taught with, travelled
with, given seminars with, laughed with, and cried with, I thank you for all you have
taught me and how special it is to have someone you can always count on to discuss
a difficult patient or a personal issue. We have become quite a team, and I value our
professional and personal relationships. Your contributions to the clinical chapters we
have done together this time have been significant. I look forward to many more pro
jects and fun times together. There is no greater pleasure for a teacher than to see a
former student travel in that teacher's tracks and surpass her. Thanks Spike!
My deepest thanks go to Elizabeth Dean. You have been an incredible colleague
who has given new life to this book. You have, in a gentle way, helped to ensure that
physiologic and scientific evidence be paired with our clinical experience and treat
ment techniques. You have truly brought about a book that I could never have com
pleted alone. Words are not enough to thank you for your commitment to this project
and the countless hours you have spent in a major revision of the former textbook. I
am delighted at what you have done and the depth of knowledge you have brought in
your content and organization of this book. I am honored that you chose this text in
which to share your work, and I have enjoyed working with you and learning from
you. We share a common bond in the relationships we have with our students and our
xv
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xvi Acknowledgements
desire to spread the word about the importance of including cardiopulmonary con
cerns in the patient's evaluation and plan of treatment. We have grown close in the
last 10 years, and I value our friendship as well as our professional work together.
T hank you hardly is enough, but 'Thanks!"
To my friends, family, and fellow workers at NovaCare, Inc. Contract Services, I
thank you for your patience and understanding of the demands on my time and your
encouragement to continue and finish this project. Your support has meant a great deal
and I hope you feel a part of this, for it is because of you this has really happened. I'm
glad to have a work environment that supports personal and professional growth.
To our Mosby staff: Martha Sasser, thanks for your ideas and vision for going with
this new book. You saw the possibilities and were there with other suggestions to
make it even better (even if some of them came when we thought we were donel). To
Kellie W hite, you kept us on track and helped catch up with chapter authors who
needed a nudge and still had time to have Julia Isabelle-quite an accomplishment!
You will now find what we have, that motherhood is often harder than your other
job! Best wishes! To Mamata Reddy and Amy Dubin, you have pushed us through
the editing process with the gentle and firm hand that we needed and with much sup
port and help. Thank you for your cooperation and critical eye in making this an ex
cellent outcome.
Finally, and most importantly, I thank God for the vision, strength, and energy to un
dertake this book and see it through to completion. My involvement in spreading the
word about the need for optimizing the cardiopulmonary system has always felt like a
mission. It has been amazing to me how many therapists don't see the need and how
they can have an "Aha!" experience in a seminar or class, or even just reading this book.
If I can have a small part in that experience, my "mission" has been fulfilled, and for that
I am grateful.
Donna Frownfelter
To Donna, for having made this dream come true. Our working relationship and
friendship began 10 years ago when I first approached Donna to review a manuscript
entitled 'The Pulmonary Effects of Body Positioning," published in Physical Therapy
in 1985. This publication was the stepping stone to a prolonged and ever-growing in
terest in oxygen transport and how it is affected by cardiopulmonary interventions
such as body positioning and mobilization. T he enthusiasm, interest, and support of
Donna and my former graduate student, Jocelyn Ross, have fueled my energies in the
exciting dynamic area of cardiopulmonary physical therapy. My heartfelt gratitude to
you both.
To Daniel Perlman, for your encouragement and support of my liaison with Donna
at the outset and over the years. You knew a good thing when you saw it.
To Doug Frost, for your support in getting this project into the end zone. Thank
you for your support and for being there as the book continued to evolve.
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Acknowledgements xvii
To our dedicated contributors, for your expertise, which has contributed to a vol
ume on the principles and practice of cardiopulmonary physical therapy that is on the
cutting edge with respect to the scientific and physiologic literature. Thank you for
your contributions and team effort.
To my cardiopulmonary physical therapy colleagues and students for your inquisi
tiveness and enthusiasm. T hank you all for your inspiration.
And not to forget the Mosby crew-Martha Sasser, Kellie White, Mamata Reddy,
and Amy Dubin-I thank each one of you for your commitment to making this book
the best it can be.
Elizabeth Dean
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CONTENTS
Chapter 1 Oxygen Transport: The Basis for Cardiopulmonary Physical Elizabeth Dean
Therapy, 3
xix
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XX Contents
Chapter 15 Monitoring Systems in the Intensive Care Unit, 229 Elizabeth Dean
Chapter 19 Physiological Basis for Airway Clearance Techniques, 321 Anne Mejia Downs
Chapter 20 Clinical Application of Airway Clearance Techniques, 339 Anne Mejia Downs
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Contents xxi
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xxii Contents
Chapter 40 The Art of Positioning and Moving Patients, 737 Mary Massery
Donna Frownfelter
Chapter 42 Care of the Patient With an Artificial Airway, 761 Lisa Sigg Mendelson
GLOSSARY, Gl
INDEX, 11
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PAR T 1
Cardiopulmonary Function
in Health and Disease
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CHAPTER 1
Elizabeth Dean
INTRODUCTION
ceptual basis for cardiopulmonary physical therapy
Cardiopulmonary physical therapy is an essential non practice. Oxygen transport is the basis for life. Impaired
invasive medical intervention that can reverse or miti or threatened oxygen transport, hence, cardiopul
gate insults to oxygen transport. It can avoid, delay, or monary dysfunction, is a physical therapy priority.
reduce the need for medical interventions, such as sup In health, the oxygen transport system is normally
plemental oxygen, intubation, mechanical ventilation, perturbed by movement and activity, changes in body
suctioning, bronchoscopy, chest tubes, surgery, and position, and emotional stress. In disease, disruption
medications. A comprehensive understanding of oxy of or threat to this system is always a medical priority
gen transpol1 and the factors that detelTnine and influ because of the threat to life or impairment of func
ence it is therefore essential to the comprehensive as tional capacity.
sessment of oxygen transport and optimal treatment The fundamental steps in the oxygen transport
prescription to effect these outcomes. pathway, and their function and interdependence are
This chapter details the oxygen transport system, the described first. Special attention is given to cellular
pathway, and the component steps that provide a coo- respiration and the utilization of oxygen during me
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4 PART I Cardiopulmonary Function in Health and Disease
+VC02
Airways/lungs
+V02
('\ ('\
. 4
c C
a a
g-
::J
g.
::J
FIGURE 1-1
Scheme of components of ventilatory-cardiovascular-metabolic doupling underlying oxygen
transport. (Modified from Wasserman K et al: Principles of exercise tesling and interpretation,
Philadelphia, 1987, Lea & Febiger.)
tabolism at the cellular level in muscle. Second, the 1992a; Goldring, 1984; Johnson, 1973; Ross, and
factors that normally perturb oxygen transport in Dean, 1989; Weber et aI, 1983).
health are described, namely gravitational stress sec Oxygen transpolt variables include oxygen delivery
ondary to changes in body position, exercise stress (002), oxygen consumption (V02) and the oxygen en
secondary to increased oxygen demand of the work hancement ratio (OER) or the utilization coefficient.
ing muscles, emotional stress, and arousal. A thor Oxygen demand is the amount of oxygen required by
ough understanding of the effects of those factors that the cells for aerobic metabolism. Oxygen demand is
normally perturb oxygen transport is essential to ac usually reflected by V02; however, in cases of severe
curately assess and treat deficits in oxygen transport. cardiopulmonary dysfunction and compromise to oxy
gen transport, V02 can fall short of the demand for oxy
gen. Oxygen transport variables, including the compo
OXYGEN TRANSPORT
nents of 002, V02, and the OER, are shown in Figure
Oxygen transport refers to the delivery of fully oxy 1-2. 002 is determined by arterial oxygen content and
genated blood to peripheral tissues, the cellular up cardiac output, oxygen consumption by the arterial and
take of oxygen, the utilization of oxygen from the venous oxygen content, difference and cardiac output,
blood, and the return of partially desaturated blood to and oxygen extraction by the ratio of 002 to \'02.
the lungs. The oxygen transport pathway consists of Measures and indices of oxygen transport that re
multiple steps ranging from the ambient air to the flect the function of the component steps of the oxy
perfusion of peripheral tissues with oxygenated arter gen transpolt pathway are shown in the box above.
ial blood (Figure 1-1). Oxygen transport has become
the basis for conceptualizing cardiopulmonary func
Energy Transfer and Cellular Oxidation
tion, and diagnosing and managing cardiopulmonary
dysfunction (Dantzker, 1983; Dantzker, Boresman, Cellular metabolism and survival depend on the con
and Gutierrez, 1991; Dean, 1994a; Dean and Ross, tinuous s y nthesis and degradation of adenosine
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Measures and Indices of the Function of the Steps in the Oxygen Transport Pathway
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6 PART I Cardiopulmonary Function in Health and Disease
Oxygen delivery
D02 Arterial oxygen content x Cardiac output
t
Oxyhemoglobin + Dissolved oxygen
t
Hgb x 1.34 x 5a02
II Pa02 x 0.003 I
Oxygen consumption
V02 = (Arterial oxygen content - Venou s oxygen content) x Cardiac output
t
Oxyhemoglobin + Dissolved oxygen
FIGURE 1-2
FOlmulas for determining oxygen delivery (002), oxygen consumption (Vo2), and oxygen
extraction ratio (OER). (Modified from Epstein CD., Henning R.1.: Oxygen transport variables
in the identification and treatment of tissue hypoxia, Heart Lung 22:328-348, 1993.)
triphosphate (A TP); the major source of energy for that oxygen delivery is inadequate, nonaerobic (anaer
biological work. Work is performed in biological sys obic or non-oxygen-requiring) energy-transferring
tems for contraction of skeletal, cardiac, and smooth processes can also supply ATP. However, supplying
muscle (e.g., exercise, digestion, glandular secretion energy anaerobically is more costly metabolically, that
and thermoregulation, and nerve impulse transmission) is, it is not efficient, is limited, and cannot be slistained
(see box below). These processes require a continuous because of the disruptive effects of lactate, a cellular
supply of A TP, which is made available by aerobic byproduct of anaerobic metabolism, on physiological
(oxygen requiring) processes primarily. In the event processes in general. Metabolic acidosis is a conse
quence of lactate accumulation. In critically ill pa
tients, the presence of metabolic acidosis secondary to
Biological Work Requiring Continuous
anaerobic metabolism can be life-threatening. Pro
Oxygen Supply
longed anaerobic metabolism is lethal in two respects.
Contraction of skeletal muscle First, the patient is increasingly dependent on anaero
Contraction of cardiac muscle bic metabolism because of inadequate oxygen delivery
Contraction of smooth muscle to peripheral tissues, and second, acidosis interferes
Nerve impulse transmission
with normal cellular processes and homeostasis, which
Active cellular metabolic processes
Active pumping mechanisms
require an optimal pH of 7.40.
The ATP molecule consists of an adenine and a ri-
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1 Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 7
---------------------
-
Lactose
I
!
Fructose- 1 ,6-diP
1
Glyceraldehyde-3P
"Glycecol
Pyn
I
te= wdale
Pr
L_____
in-: Amino acids F t:_
Acetyl-Co-A -- Fatty acids -- 1 __
o -a
)+
Citrate
CO2 + Energy
": ;
a Ketoglutarate
FIGURE 1-3
Interrelationships among carbohydrate, fat, and protein metabolism and their points of entry
into the Krebs cycle. (Printed with permission from Shepard R.J,: Physiology and biochemistry
of exercise, Phi ladelphia, 1985, Praeger Scientific.)
bose molecule with three phosphates attached. Split electron transfer chain and then use this energy for
ting of the terminal phosphate bond or the two terminal biological work (Ganong, 1993; Shephard, 1985).
phosphate bonds generates considerable amounts of Carbohydrates, fats, and proteins, ingested from
energy. This energy is used to power various chemical foodstuffs in the diet, are oxidized to provide the en
reactions associated with metabolism. These metabolic ergy for phosphorylation of adenosine diphosphate
processes take place in specialized organelles in the (ADP), that is, the formation of ATP by combining
cells called mitochondria. The primary pathways that ADP with phosphate. These substances are broken
are responsible for the formation of ATP are the Krebs down, and they access the Krebs cycle at the pyruvic
cycle and the electron transfer chain. acid or acetyl coenzyme A (CoA) levels (Figure 1-3).
The complex, enzymatically controlled chemical Some amino acids can enter the Krebs cycle directly.
reactions of metabolism are designed to form and The Krebs cycle degrades acetyl CoA to carbon
conserve energy through the Krebs cycle and the dioxide (C02) and hydrogen atoms (H2)' The primary
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8 PART I Cardiopulmonary Function in Health and Disease
3ADP
3ATP
Mitochondrion
Shuttle
Krebs cycle
NADH etc.
FIGURE 1-4
Electron transfer chain and its with the Krebs (Printed with permission from
and Philadelphia, 1985, Scientific.)
purpose of this is to generate hydrogen ions for tivity and energy is primarily by
the electron transfer chain by two principal electron aerobic metabolism. Oxygen for this process is pro
acceptors, nicotinamide adenine dinucleotide vided by the oxygen transport pathway. Carbon com
and flavin adenine dinucleotide (FAD). pounds that enter the in the form of
the numerous reactions of the Krebs and oxidative metabolism
Cellular oxidation or respiration refers to the func in the form of aerobic glycolysis in the mitochondria
tion of the electron transfer chain to release energy in in the of the cells.
small amounts and to conserve energy in the forma The Krebs and the electron transfer chain are
tion of high energy bonds. It is this process that en the biochemical in the mitochondria of the
sures a continual energy supply to meet the needs of cell responsible for harnessing the oxygen for aerobic
metabolism 1-4). metabolism and a continuous supply of oxy
Three major of energy transfer exist to gen for this process (Shephard, 1985).
supply energy all-out exercise over cose is to produce two molecules of
durations Katch, and Karch, I ATP (glycolysis). Glucose is oxidized to
though these systems are discrete they Cellu molecules of yielding a net
lar ATP and creatine phosphate (CP) are immediate molecules of ATP per molecule of
energy sources for the first 10 seconds of exercise. pyruvate molecules enter the Krebs where they
From 30 to 60 glycolysis a short are oxidized to and water. This process 30
term energy source. The ATP-CP system and the ATP molecules. Hydrogen ions released in the
colytic system are anaerobic processes. As exercise process are transferred to the electron transfer chain
persists for several minutes, the aerobic yielding 4 ATP molecules for cellular metabolism.
system oredominates. Thus for sustained ohvsical ac- Electrons are removed from hydrogen and funnelled
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1 Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 9
Sarcoplasmic
Triad reticulum Mitochondrion
j i
Terminal Transverse
A cisterns tubule
Thick myofilament
Z M Z
line line line
H zone
Sarcomere
!
'--11
" " Mi"
.-!n ,n, ,,/ ' . '
"
,'"
.
'"''
"
'
"
. .. . . _ _
.
B
, , , . .
. ... .... . . ,", ' . , ",,', . " ...
:
, .
:',', : . : :
' ::: . :
. '. ,' , .
: :: :: :
, : ::�
',
:> ,'7:'>
' ' • • • ••
. , •• '-" ,•• " . 11/ . . .. " _ ._ "
.. .
, " " ' // , > '
,
,'
' ',
.
. , . " " , , / / , " // , .
."-" ,- . . , . . ,,, .
'" . . . , .. .. , ' ... '/ "
.- . '.'
.
. . ' - ." . . . . ' '''
/ "
" , " "
. . . , ... - ... ..
' . , , , ... ... , ...
..
Thin myofilament I /
'
Thick myofilament Cross bridge H z one Z line
FIGURE 1-5
Schematic of the ultrastructure of a muscle fiber. A, View of muscle mem brane structure and
myofibril arrangement. B, A single functional unit (sarcomere) of a myofibril showing the
interdigitation of the actin and myosin filaments. (Printe d with permission from Tortora, G.J.,
A nagnostakos N.P.: Principles of anatomy and physiology, New York, J 990, Harper & Row.)
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10 PART I Cardiopulmonary Function in Health and Disease
Thin
Myosin
(thick)
Thin
FIGURE 1-6
Arrangement of the thick and thin myofilaments. (From Hasson S.: Clinical exercise physiology,
St. Louis, 1994, Mosby.)
down the electron transport chain by specialized elec anaerobic metabolism can only serve as a shol1-term
tron carrier molecules, cytochromes 1 to S. It is only energy source.
the last of these cytochromes, cytochrome oxidase,
that can reduce molecular oxygen to water. This
Muscle Contraction and Metabolism
process is driven by a gradient of high-to-Iow poten
tial energy. The energy transferred as electrons are The basic mechanism for muscle contraction is excita
passed from H2 to O2, and is trapped and conserved tion contraction coupl ing (Kirchberger, 1991; T0I10ra,
as high energy phosphate bonds. Oxygen is only in and Anagnostakos, 1990). Action potentials mediated
volved in these metabolic pathways at the end of the centrally or through the spinal cord depolarize the
electron transfer chain, where oxygen is the final muscle cell membrane, the sarcolemma, and stimulate
electron acceptor and combines with H2 to form H20. the release of calcium from the lateral sacs of the sar
More than 90% of ATP synthesis takes place through coplasmic reticulum, The sarcoplasmic reticulum is an
the electron transfer chain by oxidative reactions extensive network of invaginations and tubular chan
combined with phosphorylation, that is, oxidative nels encasing the muscle fibers or myofibrils. The cal
phosphorylation. An individual's peak aerobic capac cium floods over the myofilaments of the myofibrils.
ity is determined by the availability of oxygen at the Myofilaments consist of thin and thick fibers, actin,
end of the electron transport chain. and myosin protein, which interdigitate with each
For each molecule of glucose that is metabolized, other giving the typical striated appearance to skeletal
36 molecules of ATP are produced; four molecules muscle (Figures I-S and 1-6). Actin is a helical mole
from substrate phosphorylation (anaerobic), and 32 cule with tropomyosin intertwined along its length.
from oxidative phosphorylation (aerobic). The low Tropomyosin normally inhibits the interaction of actin
ATP yield from anaerobic metabolism explains why and myosin. Calcium causes a conformational change
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Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 11
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12 PART I Cardiopulmonary Function in Health and Disease
d(/
relatively minimal amount of oxygen that is dis
solved in the blood. The oxyhemoglobin dissociation
150
curve represents the relationship between the affinity A;
c l o
of hemoglobin for oxygen and arterial oxygen ten
sion. The affinity of hemoglobin for oxygen depends
on the tissue oxygen demand. In health, exercising :¥100
muscle increases the demand for oxygen. The heat of
the working muscles and the acidic environment re
E
E
o
N
0....
Gal enp/ An
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1 Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 13
Preload
to that consumed. The OER is calculated by dividing
Preload is the end diastolic muscle fiber length of the V02 by 002. Normally, the OER is 23%.
ventricle before systolic ejection, and reflects the left
ventricular end diastolic volume (LVEDV). The
Supply-dependent Oxygen Consumption
LVEDV is dependent on venous return, blood vol
ume, and left atrial contraction. An increase in ven Normally, a decrease in 002 does not reduce V02
tricular volume stretches the myocardial fibers and (Phang, Russell, 1993). With a decrement in 002, the
increases the force of myocardial contraction (Star tissues extract a proportionate amount of oxygen
ling effect) and stroke volume. This effect is limited from the blood. In critically ill patients, the 002 may
by the physiologic limits of distension of the my- . be significantly limited to the point where basic
2
ocardium. Excessive stretching such as in fluid over metabolic needs for oxygen (300 mllminJM ) are not
load of the heart leads to suboptimal overlap of the being met (Fenwick et ai, 1990; Lorente et aI, 1991;
actin and myosin filaments, thus impairing rather Phang, Russell, 1993). The critical level at which V02
than enhancing contractility. falls is associated with tissue anaerobic metabolism
and the development of lactic acidosis and decreased
pH (Figure 1-8) (Mizock, Falk, 1992; Schumaker,
Afterload
Cain, 1987). Serum lactates correspondingly increase
Afterload is the resistance to ejection during ventricu and provide a valid index of anaerobic metabolism in
lar systole. Afterload of the left ventricle is primarily patients with multiorgan system failure.
determined by four factors: the distensibility of the
aorta, vascular resistance, patency of the aortic valve,
The Oxygen Transport Pathway
and viscosity of the blood.
Oxygen transport is dependent on several intercon
necting steps ranging from oxygen-containing air
Myocardial Contractility
being inhaled through the nares to oxygen extraction
Myocardial contractility reflects actin-myosin coupling at the cellular level in response to metabolic demand
during contraction. Myocardial contractility is assessed (see Figure I-I , p. 4). These steps provide the mecha
by the ejection fraction, rate of circumferential muscle nism for ventilatory, cardiovascular, and metabolic
fiber shortening, pressure volume relationships, and the coupling. In addition, blood is responsible for trans
rate of change of ventricular pressure over time. porting oxygen within the body, thus its constituents
and consistency directly affect this process.
Oxygen Debt
The Quality and Quantity of Blood
Tissue oxygen debt or recovery oxygen consumption is
the difference between oxygen demand and oxygen Although not considered a discrete step in the oxygen
consumption. In health, oxygen debt can be sustained transpolt pathway, blood is the essential medium for
for short periods during intense exercise. Anaerobic me transporting oxygen. To fulfill this function, blood
tabolism is stimulated to produce ATP under these con must be delivered in an adequate yet varying amount
ditions. In patients, the degree of oxygen debt signifi proportional to metabolic demands, and have the ap
cantly correlates with survival (Fenwick et aI, 1990). propriate constituents and consistency. Thus consider
ation of the characteristics of the circulating blood vol
ume is essential to any discussion of oxygen transport.
Oxygen Extraction Ratio or Utilization Coefficient
Blood volume is compartmentalized within the in
The oxygen extraction ratio (OER), or utilization co travascular compartment such that 70% is contained
efficient, reflects the proportion of oxygen delivered within the venous compartment, 10% in the systemic
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14 PART I Cardiopulmonary Function in Health and Disease
arteries, 15% in the pulmonary circulation, and 5% In Blood is a viscous fluid composed of cells and
the capillalies (Sandler, 1986). The large volume of plasma. Because 99% of the blood is red blood celis,
blood contained within the venous circulation permits the white blood cells play almost no role in determin
adjustments to be made as cardiac output demand ing the physical characteristics of blood.
changes. The veins constrict, for example, when car Hematocrit refers to the proportion of blood that is
diac output needs to be increased. When blood vol 38% for women and
celis. The normal hematocrit is
ume is normal and body fluids are appropriately dis 42% for men. Blood is several times as viscous as
t r i b u t e d b e t w e e n t h e i n t r a- a n d e x t r ava scular water, which increases the difficulty with which
compartments, fluid balance is considered normal. blood is pumped through the heart and flows through
When these are disrupted, a fluid balance problem vessels; the greater the number of cells, the greater
exists. In addition, fluid imbalance affects the con the friction between the layers of blood, which results
centration of electrolytes, and particularly sodium, in increased viscosity. Thus the viscosity of the blood
which is in the highest concentration in the extracel increases significantly with increases in hematocrit.
lular fluid. Four primary fluid problems that have im An increase in hematocrit such as in polycythemia in
plications for oxygen transport are water deficit, creases blood viscosity several times over. The con
water excess, sodium deficit, and sodium excess (see centration and types of protein in the plasma can also
Chapter 15). Other ions that are often affected in affect viscosity but to a lesser extent.
fluid and electrolyte imbalance deficits include potas In the adult, red blood cells are produced in the
sium, chloride, calcium, and magnesium (Figure 1-8). marrow of the membranous bones such as the verte
These electrolyte disturbances also contribute to im brae, sternum, ribs, and pelvis. The production of red
paired oxygen transport by affecting the electrical blood cells from these sites diminishes with age. Tis
and mechanical behavior of the heart and blood ves sue oxygenation is the basic regulator of red blood
sels, and hence cardiac output and the distribution of cell production. Hypoxia stimulates red blood cell
oxygenated arterial blood to the periphery. production through erythropoietin production in bone
(Guyton, 1991).
Viscosity of the blood has its greatest effect in the
small vessels. Blood flow is considerably reduced in
small vessels, resulting in aggregates of red blood ceils
c
.Q adhering to the vessel walls. This etlect is not offset by
c... D02 Dependent D02 Independent
E the tendency of the blood to become less viscous in
I
'"
c
I small vessels as a result of the alignment of the blood
o I
u I cells flowing through, which minimizes the frictional
c I
Q)
: Critical D02 forces between layers of flowing blood cells. In addi
g I
I
I
I
tion, in small capillaries, blood cells can become stuck
particularly where the nuclei of endothelial cells pro
trude and momentarily block blood flow.
o 100 200 300 400 500 600 700
The major function of the red blood cells is to
Oxygen delivery (ml/min)
transport hemoglobin, which in turn carries oxygen
from the lungs to the tissues. Red blood cells also
FIGURE 1-8
contain a large quantity of carbonic anhydrase, which
Relationship between oxygen consumption (Voz) and
catalyzes the reaction between COz and HzO. The ra
oxygen delivery (002)' The Dorindependent phase
represents the normal metabolic state. The D02-dependent pidity of this reaction makes it possible for blood to
phase represents the dependency of Voz on 002 when 002 react with large quantities of CO2 to transport it from
Falls below the critical 002. (Modified from Phang, P.T. the tissues to the lungs for elimination.
and Russel, 1.A.: When does V02 depend on D02? Resp Hemoglobin is contained within red blood cells up
Care 38: 618-630, 1993.) to a concentration of 34 gmll 00 ml of cells. Each
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1 Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 15
gram of hemoglobin is capable of combining with blood cells. These values vary according to gender,
1.34 ml of oxygen (see Figure 1-2, p. 6). Therefore in weight, and other factors. Normally, changes in blood
healthy women, 19 ml of oxygen and in healthy men, volume reflect deficits and excesses of fluid through
21 ml of oxygen can be carried in the blood, given imbalances created by losses through the skin and
that the whole blood of women contain an average respiratory tract, and through urinary, sweat, and
of 14 gmll 00 ml of blood and 16 gmll 00 ml of blood fecal losses. Exercise and hot weather are major chal
in men. lenges to fluid balance in health.
Clotting factors of the blood are normally in a pro The plasma contains large quantities of sodium
portion that does not promote clotting. Factors that and chloride ions, and small amounts of potassium,
promote coagulation (procoagulants), and factors that calcium, magnesium, phosphate, sulfate, and organic
inhibit coagulation (anticoagulants) circulate in the acid ions. In addition, plasma contains a large amount
blood. In the event of a ruptured blood vessel, pro of protein. The large ionic constituents of the plasma
thrombin is converted to thrombin, which catalyzes are responsible for regulating intracellular and extra
the transformation of fibrinogen to fibrin threads. cellular fluid volumes and the osmotic factors that
This fibrin mesh captures platelets, blood cells, and cause shifts of fluid between the intracellular and ex
plasma to form a blood clot. tracellular compartments.
The extreme example of abnormal clotting is dis
seminated intravascular coagulation, where both he
Oxyhemoglobin Dissociation
mOlThage and coagulation occur simultaneously. The
acute form of this syndrome occurs in critically ill pa The demand for oxygen at the cellular level changes
tients with multiorgan system failure. The mechanism from moment to moment. The properties of oxyhemo
appears to involve tissue factors, factors that damage globin dissociation ensure that there is a continuous
the blood vessel wall, and factors that increase supply of oxygen at the cellular level. Oxygen com
platelet aggregation (Green and Esparaz, 1990). The bines with the hemoglobin molecules in the pul
chronic form of the syndrome occurs in chronic con monary circulation and then is released in the tissue
ditions such as neoplastic disease. capillaries in response to a reduced arterial oxygen
Plasma is the extracellular fluid of the blood and tension. The S-shaped oxyhemoglobin dissociation
contains 7% proteins, namely albumin, globulin, and curve (see Chapter 9) shifts to the right in response to
fibrinogen. The primary function of the albumin and reduced tissue pH, increased CO2, increased tempera
to a lesser extent, globulin and fibrinogen, is to create ture and increased diphosphoglycerate (DPG), a con
osmotic pressure at the capillary membrane and to stituent of normal blood cells.
prevent fluid leaking into the interstitial spaces. The The delivery of blood and its ability to effectively
globulins serve as carriers for transporting substances transport oxygen is central to all steps in the oxygen
in the blood and provide immunity as the antibodies transport pathway and must be considered at each
that fight infection and toxicity. Fibrinogen is funda step in clinical problem solving and decision making.
mental to blood clotting. The majority of blood pro
teins, including hemoglobin, are also excellent acid
Steps in the Oxygen Transport Pathway
base buffers and are res ponsi b Ie for 70% of a II
buffering power of whole blood.
Blood flow (Q) depends on a pressure gradient (P) Step One: inspired oxygen and quality
blood flow equals the pressure gradient divided by re In health, the concentration of inspired oxygen is rel
sistance. The length of a given blood vessel and the vis atively constant at 21 % unless the individual is at al
cosity of the blood are also detelTninants of blood flow. titude. In which case, the fraction of inspired oxygen
The average blood volume is 5,000 ml. Approxi is reduced the higher the elevation.
mately 3,000 ml of this is plasma and 2,000 ml is red Atmospheric air consists of 79% nitrogen, 20.97%
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16 PART I Cardiopulmonary Function in Health and Disease
oxygen and 0.03% CO2. Because nitrogen is not ab lined with cilia, fine microscopic hair-like projec
sorbed in the lungs, it has a crucial role in maintain tions, which are responsible for wafting debris, cells,
ing the lung tissue patent. The constituents of the air and microorganisms away from the lungs into larger
have become an increasingly important social, envi airways to be removed and evacuated. The airways
ronmental, and health issue because of environmental are also lined with mucus, which consists of two lay
hazards, pollution, and thinning of the ozone layer re ers, the upper gel layer and the lower sol layer with
sulting in deterioration of air quality, an increase in which the cilia communicate.
toxic oxygen free radicals and a reduction in atmos
pheric oxygen pressure.
Step Three: lungs and chest wall
Many factors influence air quality, (e.g., geo Air entry to the lungs depends on the integrity of the
graphical area, season, urban vs. rural area, high vs. respiratory muscles, in particular, the diaphragm, the
Jow elevation, home environment, work environment, lung parenchyma, and the chest wall. Contraction and
indoor vs. outdoor, level of ventilation, air condition descent of the diaphragm inflates the lungs. The dis
ing, enclosed buildings, areas with high particu late tribution of ventilation is primarily determined by the
matter, areas with gaseous vapors and toxic-inhaled negative intrapleural pressure gradient down the
materials, and smoke-filled vs. smoke-free environ lungs. The negative intrapleural pressure gradient re
ments). Poor air quality contributes to changes in the sults in uneven ventilation down the lung, and inter
filtering ability of the upper respiratory tract, airway regional differences (see Chapter 3). However, there
sensitivity, and lung damage, acutely and over time. are other factors, intraregional differences, that con
Chronic irritation of the lungs from poor air quality tribute to uneven ventilation within regions of the
can lead to allergies, chronic inflammatory reactions, lung. These intraregional differences reflect regional
fibrosis, and alveolar capillary membrane thickening. differences in lung compliance and airway resistance
At the alveolar level, the inspired air is saturated with (Ross, Dean, 1992). In patients with partially ob
water vapor. In dry environments, however, the upper structed airways, reduced lung compliance, and in
respiratory tract may become dehydrated, lose its creased airway resistance increase the time for alveo
protective mucous covering, become eroded, and pro lar filling. Gas exchange is compromised if there is
vide a portal of infection even though the air is ade inadequate time for alveolar filling or emptying, that
quately humidified by the time it reaches the lower is, increased time constants (West, 1995). Different
airways and alveoli. time constants across lung units contribute to uneven
patterns of ventilation during inspiration. A lung unit
Step Two: airways
with a long time constant is slow to fill and to empty,
The structure of the airways down the respiratory and may continue to fill when sun'ounding units are
tract change according to their function. The main emptying. A second factor is altered diffusion dis
airway, the trachea, consists of cartilagenous rings, tance. In diseases where diffusion distance is i n
connective tissue, and small amounts of smooth mus creased, ventilation along lung units is uneven.
cle. This structure is essential to provide a firm and The lungs and the parietal pleura are richly sup
relatively inflexible conduit for air to pass from the plied with thin-walled lymphatic vessels (Guyton,
nares through the head and neck to the lungs, and 1991). Lymphatic vessels have some smooth muscle
avoid airway collapse. As the airways become and thus can actively contract to propel lymph fluid
smaller and branch throughout the lung tissue, they forward. This forward motion is augmented by
consist primarily of smooth muscle. Airway narrow valves along the lymphatic channels. The rise and
ing, or, obstruction and increased resistance to air fall of the pleural pressure during respiration com
flow, is caused by multiple factors, including edema, presses lymphatic vessels with each breath, which
mUCllS, foreign objects, calcification, particulate mat promotes a continuous flow of lymph. During expi
ter and space-occupying lesions, as well as hyperre ration and increased intrapleural pressure, fluid is
activity of bronchial smooth muscle. The airways are forced into the lymphatic vessels. The visceral pleura
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Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 17
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18 PART I Cardiopulmonary Function in Health and Disease
process is normally facilitated with increased volumes sels, the greater their sensitivity to both exogenous
of blood in the hemt and each ventricular systole. neural stimulation and endogenous stimulation by cir
culating humoral neurotransmitters such as cate
Step Seven: peripheral circulation cholamines and local tissue factors. This sensitivity is
Once oxygenated blood is ejected from the heart, the essential for the moment-to-moment regulation of the
peripheral circulation provides a conduit for supply peripheral circulation with respect to tissue perfusion
ing this blood to metabolically active tissue. Blood and oxygenation, commensurate with tissue meta
vessels throughout the body are arranged both in se bolic demands, and control of total peripheral resis
ries and in parallel. The arteries and capillaries are tance and systemic blood pressure.
designed to advance blood to pelfuse the tissues with
oxygenated blood. The vasculature is architected so
Step fight: tissue extraction
tion of connective tissue and elastic elements than Perfusion of the tissues with oxygenated blood is the
distal medium and small arteries, which have a pro p r i n c i p a l goal of t he oxygen transport system
gressively higher proportion of smooth muscle. This (Dantzker, 1993). Oxygen is continually being used
structure enables the large proximal arteries to with by all cells in the body, thus it diffuses out of the cir
stand high pressure when blood is ejected during ven culation and through cell membranes very rapidly to
tricular systole. Considerable potential energy is meet metabolic needs. Diffusion occurs down a gra
stored within the elastic walls of these blood vessels dient from areas of high to low oxygen pressure. The
as the heart contracts. During diastole, the forward distance between the capillaries and the cells is vari
propulsion of blood is facilitated with the elastic re able, thus a significant safety factor is required to en
coil of these large vessels. The thin-walled muscular sure adequate arterial oxygen tensions. Intracellular
arterioles serve as the stopcocks of the circulation and P02 ranges from 5 to 60 mm Hg, with an average of
regulate blood flow through regional vascular beds 23 mm Hg (Guyton, 1991). Given that only 3 mm
and maintain peripheral vascular resistance to regu Hg of oxygen pressure are needed to support metab
late systemic blood pressure. Blood flow through olism, 23 mm Hg of oxygen pressure provide an ade
these regional vascular beds is determined by neural quate safety margin. Thcsc mechanisms ensure an
and humoral stimulation, and by local tissue factors. optimal oxygen supply over a wide range of varying
Blood pressure control is primarily regulated b y oxygen demands in health and in the event of im
neural stimulation of the peripheral circulation and paired oxygen delivery because of illness. Normally,
these vascular beds. the rate of oxygen extraction by the cells is regulated
The microcirculation consists of the precapillary ar by oxygen demand by the cells, that is, the rate at
teriole, the capillary, and the venule. The Starling effect which ADP is formed from A TP and not by the
govems the balance of hydrostatic and oncotic pres availability of oxygen.
sures within the capillary and the surrounding tissue. The adequacy of the quality and quantity of the mi
The balance of these pressures is 0.3 mrn Hg; its net ef tochondrial enzymes, required to support the Krebs
fect is a small outward filtration of fluid from the mi cycle and electron transfer chain, and the availability
crovasculature into the interstitial space (see Chapter 3). of myoglobin may be limiting factors in the oxygen
Any excess fluid or loss of plasma protein is drained transport pathway secondary to nutritional deficits and
into the sun'ounding lymphatic vessels, which usually muscle enzyme deficiencies. Myoglobin is a compara
has a small negative pressure as does the interstitium. ble protein to hemoglobin that is localized within
The integlity of the microcirculation is essential to reg muscle mitochondria. Myoglobin combines reversibly
ulate the diffusion of oxygen across the tissue capillary with oxygen to provide an immediate source of oxy
membrane, and to remove CO2 and waste products. gen with increased metabolic demands and facilitate
The greater the muscular component of blood ves oxygen transfer within the mitochondria.
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Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 19
Normally, the amount of oxygen extracted by the ergy expenditure, and thus increase rate of metabolism.
tissues is 23%, that is, the ratio of oxygen consumed Several factors related to disease can significantly
to oxygen delivered. Thus this ratio ensures that con increase oxygen consumption and metabolic rate over
siderably greater amounts of oxygen can be extracted and above BMR. Such factors include fever, the dis
during periods of increased metabolic demand. ease process itself, the process of healing and recov
ery from injury or disease, thermoregulatory distur
Step Nine: return of partially desaturated
bance, reduced arousal, increased arousal resulting
blood and C02 to the lungs
from anxiety and pain, sleep loss, medical and surgi
Partially desaturated blood and CO2 are removed cal interventions, fluid imbalance, and medications
from the cells via the venous circulation to the right Dean, 1994b). These factors may contribute to a sys
side of the heart and lungs. C02 diffuses across the temic increase in BMR or may reflect local changes in
alveolar capillary membrane and is eliminated from tissue metabolism. Autoregulation of the regional vas
the body through the respiratory system, and the de cular beds promotes increased regional blood flow in
oxygenated venous blood is reoxygenated. The oxy accordance with their local tissue metabolic demand.
gen transport cycle repeats itself and is sensitively Because gravitational stress and exercise stress are
tuned to adjust to changes in the metabolic demand of fundamental to normal cardiopulmonary function and
the various organ systems, such as digestion in the GI oxygen transport, the effects of gravity and exercise are
system, and cardiac and muscle work during exercise. highlighted. It should be emphasized that the effects of
Factors that intelfere with tissue oxygenation and gravity on fluid shifts and the systeIllic effects of exer
the capacity of the tissue to use oxygen include ab cise are physiologically distinct, that is, exposing an in
normal oxygen demands, reduced hemoglobin and dividual to a gravitational stress does not adapt that in
myoglobin levels, edema, and poisoning of the cellu dividual to an exercise stress and vice versa. These two
lar enzymes (Kariman, Burns, 1985). factors also augment arousal, through stimulation of the
reticular activating system in the brain stem and the au
tonomic nervous system (ANS), which when de
FACTORS THAT NORMALLY PERTURB
pressed, significantly compromises oxygen transport in
OXYGEN TRANSPORT
patient populations. The impact of emotional stress on
Basal metabolic rate (BMR) reflects the rate of me oxygen transport is discussed briefly. These concepts
tabolism when the individual is in a completely are described fUlther in Chapters 17 and L8.
rested state, that is, no food intake within several
hours, after a good night's sleep, no arousing or dis
Gravitational Stress
tressing emotional stimulation, and at a comfortable
ambient temperature. Normally, the BMR is constant Humans are designed to function in a I G gravita
within and between individuals if measured under tional field. Given that 60% of the body weigllt is
standardized conditions. This rate reflects resting en fluid contained within the intra- and extravascular
ergy expenditure of the body's cells to maintain rest compartments, and that this fluid has considerable
ing function, including the work of breathing; heart, mass, changes in body position result in significant
renal, and brain function; and thermoregulation. fluid shifts instantaneously and threaten hemody
Normally, over the Course of the day, the human namic stability (Dean, Ross, 1992a; Dean, Ross,
body is exposed to fluctuations in ambient temperature 1992b). To maintain consciousness and normal body
and humidity, ingestion states, activity and exercise function during changes in body position, the heart
levels (exercise stress), body positions and body posi and peripheral vasculature are designed to detect
tion changes (gravitational stress), emotional states these fluid shifts and accommodate quickly to avoid
(emotional stress) and states of arousal. These factors deleterious functional consequences (e.g., reduced
significantly influence oxygen consumption and en stroke volume, CO, circulating blood volume, and
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20 PART I Cardiopulmonary Function in Health and Disease
cerebral perfusion). The preservation of the f1uid The oxygen transport system is designed to deliver
regulating mechanisms is essential to counter the he oxygen from the ambient air to every cell in the body
modynamic effects of changing body position. This to support cellular respiration, that is, the metabolic
capacity is quickly lost with recumbency and is the utilization of oxygen at the cellular level. Blood is the
primary cause of bed rest deconditioning in patient essential medium in which cellular and noncellular
and older populations (Chase, Grave, Rowell, 1966; components transport oxygen from the cardiopul
Winslow, 1985). Restoration of gravitational stress monary unit to the peripheral tissues. The fundamental
with upright positioning is the only means by which steps in the oxygen transport pathway were described.
these fluid-regulating mechanisms can be maintained These steps included the quality of the ambient air, the
and orthostatic intolerance and its short- and long airways, lungs, chest wall, pulmonary circulation, lym
term sequelae averted. phatics, he31t, peripheral circulation, and the peripheral
tissues of the organs of the body.
In health, the most significant factors that perturb
Exercise Stress
oxygen transport are changes in gravitational stress
Exercise constitutes the greatest perturbation to home secondary to changes in body position, exercise stress
ostasis and oxygen transport in humans. Cardiac output secondary to increased oxygen demand of working
can increase five times to adjust to the metabolic de muscles, arousal, and emotional stress. A thorough
mands of exercise stress. All steps in the oxygen trans understanding of the normal effects of gravitational
port pathway are affected by exercise stress. Ventilation and exercise stress and arousal is essential to under
is increased, and ventilation and perfusion matching is stand deficits in oxygen transport. In disease, numer
optimized to maximize oxygenation of blood. Heart ous factors impair and threaten oxygen transport, that
rate and stroke volume are increased to effect greater is, underlying pathophysiology, restricted mobility,
cardiac output of oxygenated blood to the tissues. At recumbency, factors related to the patient's care, and
the tissue level, oxygen extraction is enhanced. factors related to the individual (see Chapter 16).
Thus the physical therapist needs a detailed under
standing of these concepts to diagnose these deficits
Emotional Stress
and prescribe efficacious treatments.
The body responds to emotional stress similar to ex
ercise stress with the sympathetic stress reaction. Per
REVIEW QUESTIONS
ceived threat, the basis of emotional stress, triggers
the fight, flight, or fright mechanism and a series of 1. Describe the oxygen transport pathway, its steps
sympathetically mediated physiological responses. and their interdependence.
This reaction that prepares the body for flight in 2. Describe the physiological processes of energy
cludes an increase in heart rate, blood pressure, CO, transfer and cellular oxidation.
blood glucose, muscle strength, mental alertness, cel 3. Explain oxygen transport with respect to oxygen
lular metabolism, and increased local blood flow to delivery, uptake and utilization and the interrela
specific muscle groups, as well as inhibition of invol tionship among these processes.
untary function. 4. Outline the factors that perturb oxygen transport
in health.
SUMMARY
References
This chapter described the oxygen transport system,
its component steps, and their interdependence. This Chase, G.A., Grave, c., & Rowell, L.B. (1966). Independence of
framework provides a conceptual basis for the prac changes in functional and performance capacities attending
prolonged bed rest, Aerospace Medicille 37: 1232-1237.
tice of cardiopulmonary physical therapy.
Copyrighted Material
Oxygen Transport: The Basis for Cardiopulmonary Physical Therapy 21
Cone, lB. (1987). Oxyg.cn transport from capillary to cell. In Sny Kariman, K., & Burns, S.R. (1985). Regulation of tissue oxygen
der, J.V., Pinsky, M.R. (eds). Oxygen transport in the criticailv extraction in disturbed in adult respiratory distress syndrome,
ill, Chicago: Year Book. A meri can Review Respi ratory Diseases 132: 109-1 14, 1985.
Dantzker, D.R. (1993). Adequacy of tissue oxygellation. Critical Kirchberger, M.A. (1991). Excitation and contraction of skeletal
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Dantzker, D.R. (1985). The intluence of cardiovascular function on sumption in acute respiratory failure, Critical Care Medicine
gas exchange. Clinical Chesl Medicine 4: 149-159. 19.'770-775, 1991.
Dantzker, D.R., Boresman, B., & Gutierrez, G. (1991). Oxygen MCArdle, W.D., Katch, F.l., & Katch, V.L. (1994). Essentials (j(
supply and utilization relationships. American Review of Respi exercise physiology, Philadelphia: Lea & Febiger.
ratory Disorders 143:675-679. Mizock, B.A., & Falk, J.L. (1992). Lactic acidosis in critical ill
Dean, E. (1994a). Oxygen transport: a physiologically-based con ness, Critical Core Medicine 20:80-93, 1992.
ceptual framework for the practice of cardiopulmonary physio Phang, P.T., Russell, J.A. (1993). When does V02 depend on D02
therapy, Physiotherapy 80:347-355. Respiratory Care 38:618-630.
Dean, E. (1994b). Physiotherapy skilis: positioning and mobiliza Ross, J., & Dean, E. (1989). Integrating physiological principles
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Edinburgh: Churchill Livingstone. Ross, J" & Dean, E. (1992). Body positioning. In e.e. Zadai (Ed.).
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physiology and physical therapy. Chest 101:1694-1698, 1992a cal therapy. New York: Churchill Livingstone.
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Cardiopulmonary Anatomy
Elizabeth Dean
Lyn Hobson
INTRODUCTION
This chapter presents the anatomy of the car
The heart lies in series with the lungs, constituting diopulmonary system, including the skeletal features
the cardiopulmonary unit, the central component of of t h e t horacic cavity; muscles of respiration;
the oxygen transport pathway (Scharf and Cassidy, anatomy of t h e tracheobronchial tree; lung
1989; Weber et ai, 1983). Virtually all the blood re parenchyma; basic anatomy of the heart; and periph
turned to the right side of the heart passes through eral, pulmonary, and lymphatic circulations (Berne
the lungs and is delivered to the left side of the heart and Levy, 1992; Burton and Hodgkin, 1984; Ganong,
for ejection to the systemic, coronary, and bron 1993; Guyton, 1991; Katz, 1992; Murray, 1986; Mur
chopulmonary circulations. Because of this interrela ray and Nadel, 1988; Nunn, 1993; West, 1991; West,
tionship, changes in either lung or heart function can 1995; and Williams et ai, 1989).
exert changes in the function of the other organ. A
detailed understanding of the anatomy of the heart
THORAX
and lungs, and how these organs work synergisti
cally is essential to the practice of cardiopulmonary The bony thorax covers and protects the principal or
physical therapy. gans of respiration and circulation, as well as the
23
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24 PART I Cardiopulmonary Function in Health and Disease
FIGURE 2-2
The relationship of the lungs to the bony thorax (posterior
view).
FIGURE 2-1
The relationship of the bony thorax and lungs to the
level with the second costal cartilages. The bifurca
abdominal contents (anterior view).
tion of the trachea into the right and left mainstem
bronchi al s o occurs at t h e sternal ang le. The
liver and the stomach (Figures 2-1 and 2-2). The pos manubrium and body are joined by fibrocartilage,
terior surface is formed by the 12 thoracic vertebrae which may ossify in later life.
and the posterior part of the 12 ribs. The anterior sur The body of the sternum is twice as long as the
face is formed by the sternum and the costal carti manubrium. It is a relatively thin bone and can be
lage. The lateral surfaces are formed by the ribs. At easily pierced by needles for bone marrow aspira
birth, the thorax is nearly circular, but during child tions. The heart is located beneath and to the left of
hood and adolescence, it becomes more elliptical the lower one third of the body of the sternum. Al
until adulthood. It is wider from side to side than it is though it is attached by cartilage to the ribs, this por
from front to back. tion of the sternum is flexible and can be depressed
without breaking. This maneuver is used, with care,
in closed cardiac massage to artificially circulate
Sternum
blood to the brain and extremities. The lower margin
The sternum, or breastbone, is a flat bone with three of the body is attached to the xiphoid process by fi
parts: the manubrium, body, and xiphoid process. brocartilage. This bone is the smallest of the three
The manubrium is the widest and thickest bone of the parts of the sternum and usually fuses with the body
sternum. Its upper border is scalloped by a central of the sternum in later life.
jugular notch, which can be palpated, and two clavic
ular notches that house the clavicles. Its lower border
Ribs
articulates with the upper border of the body at a
slight angle, the sternal angle or angle of Louis. This A large portion of the bony thoracic cage is formed
angle can be easily palpated, is a landmark located by 12 ribs located on either side of the sternum. The
between thoracic vertebrae T4 and TS, and is on a first seven ribs connect posteriorly with the vertebral
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2 Cardiopulmonary Anatomy 25
FIGURE 2-3
The movements of the r ibs. A, "Bucket handle," lower rib. B, "Pump handle," first rib.
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26 PART I Cardiopulmonary Function in Health and Disease
MUSCLES OF RESPIRATION
Inspiration
Diaphragm
The diaphragm is the principal muscle of respiration.
During quiet breathing, the diaphragm contributes ap
proximately two thirds of the tidal volume in the sit
ting or standing positions, and approximately three
fourths of the tidal volume in the supine position. It is
also estimated that two thirds of the vital capacity in
all positions is contributed by the diaphragm.
The diaphragm is a large, dome-shaped muscle
that separates the thoracic and abdominal cavities. Its FIGURE 2-4
upper surface supports the pericardium (with which it The diaphragm from below.
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2 Cardiopulmonary Anatomy 27
( --------
?
I t.
\ ff�
'--- -----
FIGURE 2-5
When the patient is lying on side, the dome of the diaphragm on the lower side rises fUI1her in the
thorax than the dome on the upper side.
aorta, thoracic duct, and sometimes the azygos vein. in this POSItIon. On x-ray, the position of the di
The diaphragm is also pierced by branches of the left aphragm can indicate whether the film was taken dur
phrenic nerve, small veins, and lymph vessels. ing inspiration or expiration, and may also indicate
The position of the diaphragm and its range of pathology in the lungs, pleurae, or abdomen.
movement vary with posture, the degree of distention Each half of the diaphragm is innervated by a sep
of the stomach, size of the intestines, size of the liver, arate nerve-the phrenic nerve on that side. Al
and obesity. The average movement of the diaphragm though the halves contract simultaneously, it is pos
in quiet respiration is 12.5 mm on the right and 12 sible for half of the muscle to be paralyzed without
mm on the left. This can increase to a maximum of affecting the other half. Generally, the paralyzed half
30 mm on the right and 28 mm on the left during in remains at the normal level during rest. However,
creased ventilation. The posture of the individual de with deep inspiration, the paralyzed half is pulled up
termines the position of the diaphragm. In the supine by the negative pressure in the thorax. A special x
position, the resting level of the diaphragm rises. The ray, moving fluoroscopy, is used to determine paral
greatest respiratory excursions during normal breath ysis of the diaphragm.
ing occur in this position. Howevcr, the lung volumes Contraction of the diaphragm increases the tho
are decreased because of the elevated position of the racic volume vertically and transversely. The central
abdominal organs. fn a sitting or upright position, the tendon is drawn down by the diaphragm as it con
dome of the diaphragm is pulled down by the abdom tracts. As the dome descends, abdominal organs are
inal organs, allowing a larger lung volume. For this pushed forward, as far as the abdominal walls will
reason, individuals who are short of breath are more allow. When the dome can descend no farther, the
comfortable sitting than reclining. fn a side-lying po costal fibers of the diaphragm contract to increase the
sition, the dome of the diaphragm on the lower side thoracic diameter of the thorax. This occurs because
rises farther into the thorax than the dome on the the fibers of the costal part of the diaphragm run ver
upper side (Figure 2-5). The abdominal organs have a tically from their attachment at the costal margin.
tendency to fall forward out of the way, allowing Thus contraction of these fibers elevates and everts
greater excursion of the dome on the lower side. fn the ribs (Figure 2-6). If the diaphragm is in a low po
contrast, the upper side moves little with respiration sition, it will change the angle of pull of the muscle's
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28 PART I Cardiopulmonary Function in Health and Disease
.-;;/
"W.M
FIGURE 2-6
Contraction of the costal fibers of the diaphragm causes rib eversion and elevation.
costal fibers. Contraction of these fibers creates a muscle forward to the sternum. There are II external
horizontal pull, which causes the lateral diameter to intercostal muscles on each side of the sternum. They
become smaller as the ribs are pulled in toward the are thicker posteriorly than anteriorly, and thicker
central tendon. than the internal intercostal muscles. They are inner
As the diaphragm descends, it compresses the ab vated by the intercostal nerves, and contraction draws
dominal organs, increasing intraabdominal pressure. the lower rib up and out toward the upper rib. This
At the same time, the intrathoracic pressure decreases action increases the volume of the thoracic cavity.
as the lung volume is increased by the descending di There are also 11 internal intercostals per side.
aphragm. Inspiratory airflow occurs as a result of this These are considered primarily expiratory in function.
decrease in intrathoracic pressure (see Chapter 3). Studies have shown that the intercartilaginous or
The pressure gradient between the abdominal and parasternal portion of the internal intercostals con
thoracic cavities also facilitates the return of blood to tracts with the external intercostals during inspiration
the right side of the heart. to help elevate the ribs. Besides their respiratory func
Movement of the diaphragm can be controlled to tions, the intercostal muscles contract to prevent the
some extent voluntarily. Vocalists spend years learn intercostal spaces from being drawn in or bulged out
ing to manipulate their diaphragms to produce the during respiratory activity.
controlled sounds during singing. The diaphragm mo
mentarily ceases movement when a person holds his
Sternocleidomastoid
or her breath. The diaphragm is invol untarily in The sternocleidomastoids (SCMs) are strong neck
volved in parturition, bearing down in bowel move muscles arising from two h e a d s , one from the
ments, laughing, crying, and vomiting. Hiccups are manubrium and one from the medial part of the clavi
spasmodic, sharp contractions of the diaphragm that cle (see Figure 2-7, p. 29). These two heads fuse into
may indicate disease (e.g., a subphrenic abscess) if one muscle mass that is inserted behind the ear into the
they persist. mastoid process. It is innervated by the accessory
nerve and the second cervical nerve. There are two of
Intercostals these muscles, one on each side of the neck. When one
The external intercostals extend from the tubercles SCM contracts, it tilts the head toward the shoulder of
of the ribs, above, down, and forward to the costo the same side and rotates the face toward the opposite
chondral junction of the ribs below, where they be shoulder. If the two SCM muscles contract together,
come continuous with the anterior intercostal mem they pull the head forward into flexion. When the head
brane (Figure 2-7). This membrane extends the is fixed, they assist in elevating the sternum, increasing
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2 Cardiopulmonary Anatomy 29
FIGURE 2-7
Respiratory muscles (anterior view).
the anteroposterior (AP) diameter of the thorax. and inferiorly to the upper surface of the first two
The SCMs are the most important accessory mus ribs (see Figure 2-7). They are innervated by related
cles of inspiration. Their contractions can be ob cervical spinal nerves. These muscles are primarily
served in all patients during forced inspiration and in supportive neck muscles, but they can assist in res
all patients who are dyspneic. These muscles become piration through reverse action. When their superior
visually predominant in patients who are chronically attachment is fixed, the scalenes act as accessory
dyspneic (sec Chapter 4). respiratory muscles and elevate the first two ribs
during inspiration.
Scalenes
The anterior, medial, a n d posterior scalenes are
Serratus Anterior
three separate muscles that are considered as a func The sen-atus anterior arises from the outer surfaces of
tional unit. They are attached superiorly to the trans the first eight or nine ribs. It curves backward, forming
verse processes of the lower five cervical vertebrae a sheet of muscle that inserts into the medial border of
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30 PART I Cardiopulmonary Function in Health and Disease
f"
(cervical nerves CS, C6, and C7). There are two of
these muscles, one on each side of the body. Normally,
they assist in forward pushing of the arm (as in boxing
or punching). When the scapulae are fixed, they act as
accessory respiratory muscles and elevate the ribs to
which they are attached.
Pectoralis Major
J
the clavicle, the sternum, and the cartilages of all the
true ribs (see Figure 2-7, p. 29). This muscle sweeps
across the anterior chest to insert into the intertuber
cular sulcus of the humerus. It is innervated by the
lateral and medial pectoral nerves and cervical nerves
CS, C6, C7, C8, and Tl. There are two of these mus
cles, one on each side of the body. This muscle acts
to rotate the humerus medially and to draw the arm
across the chest. In climbing and pull-ups, it draws
the trunk toward the arms. In forced inspiration when
the arms are fixed, it draws the ribs toward the arms,
thereby increasing thoracic diameter.
Pectoralis Minor
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2 Cardiopulmonar)' Anatomy 31
The erector spinae is a large muscle extending from This muscle originates from the lumbar fascia, the an
the sacrum to the skull (see Figure 2-8, p. 30). It orig terior two thirds of the iliac crest, and the lateral two
inates from the sacrum, iliac crest,
and the spines of thirds of the inguinal ligament (see Figure 2-7, p. 29).
the lower thoracic and lumbar vertebrae. It separates Its post eri or fibers run almost vertically upward to in
into a lateral iliocostalis, an intermediate longissimus, selt into the lower borders of the last three ribs. The
and a medial spinalis column. This muscle mass in other fibers join an aponeurosis attached to the costal
serts into various ribs and vertebral processes all the margin above, the linea alba in the midline and the
way up to the skull. It is innervated by the related pubic crest below. It is innervated by the lower six tho
spinal nerves. These muscles extend, laterally flex, racic nerves and the first lumbar spinal nerves.
and rotate the vertebral column. They are considered
accessory respiratory muscles through their extension Transversus Abdominis
of the vertebral column. In deep inspiration, these The transversus abdominis arises from the inner sur
muscles extend the vertebral column, allowing fur face of the lower six costal caltilages, the lumbar fas
ther elevation of the ribs. cia, the anterior two thirds of the iliac crest, and the
lateral one third of the inguinal ligament (see Figure
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32 PART I Cardiopulmonary Function in Health and Disease
Patients with weak abdominal muscles (from neuro upper ribs move forward and upward (Cherniack and
muscular diseases, paraplegia, quadriplegia or exten Cherniack, 1983).
sive abdominal surgery) often have ineffective coughs Quiet expiration is passive and involves no mus
(see Chapters 28 and 33). cular contraction although some electrical activity
The four abdominal muscles have many other can be detected. The inspiratory muscles relax, caus
nonrespiratory functions both individually and as a ing intrathoracic pressure to be raised as the ribs and
group; these are not discussed here. diaphragm compress the lungs by returning to their
preinspiratory positions. This increased pressure al
internaiintercostais lows air flow from the lungs.
There are II internal intercostal muscles on each side In forced inspiration, a large number of accessory
of the thorax. Each muscle arises from the floor of muscles may contract in addition to the normal in
the costal groove and cartilage, and passes inferiorly spiratory muscles mentioned. The erector spinae
and posteriorly to insert on the upper border of the rib contract to extend the vertebral column. This exten
below. These internal intercostals extend from the sion permits greater elevation of the ribs during in
sternum anteriorly, around the thorax to the posterior s piration. Va rious back muscles ( e .g., erector
costal angle. They are generally divided into two spinae, trapezius, and rhomboids) contract to stabi
parts-the interosseous portion located between the lize the vertebral column, head, neck, and scapulae.
sloping parts of the ribs, and the intercartilaginous This enables accessory respiratory muscles to assist
portions located between costal carti lages. As dis inspiration through reverse action. The SCM raises
cussed previously, the intercartilaginous portions are the sternum. The scalenes elevate the first two ribs.
considered inspiratory in function. Contraction of the The serratus anterior, pectoralis major, and pec
interosseous portions of the intercostals depresses the toralis minor assist in elevating the ribs bilaterally.
ribs and may aid in forceful exhalation. This muscle All these accessory muscles tend to elevate the ribs,
is innervated by the adjacent intercostal nerves. thus increasing the AP diameter but not the trans
verse diameter of the thorax. (In fact, the transverse
diameter does increase slightly as a result of the in
SUMMARY OF RESPIRATORY MOVEMENTS
creased strength of the contraction of the normal in
In quiet inspiration, the diaphragm, external inter spiratory muscles.) The marked increase in AP di
costals, and intercartilaginous portions of the internal ameter in relation to transverse diameter creates an
intercostals are the primary muscles that contract. impression of en bloc breathing in the patient using
The diaphragm contracts first and then descends, en accessory muscles.
larging the thoracic cage vertically. When abdominal In forced expiration, the interosseous portion of
contents prevent its further descent, the costal fibers the internal intercostals and the abdominal muscles
of the diaphragm contract, causing the lower ribs to contract to force air out of the lungs. Forced expira
swing up and out to the side (bucket-handle move tion can be slow and prolonged (as in patients with
ment). This lateral rib movement is assisted by the COPD) or rapid and expulsive (as in a cough). If the
external intercostals and the intercartilaginous portion abdominal contractions are strong enough, the trunk
of the internal intercostals. The transverse diameter of flexes during exhalation. This flexion further com
the thorax is increased by this bucket-handle move presses the lungs, forcing more air from them.
ment. Finally, the upper ribs move forward and up
ward (pump-handle movement) also through contrac
UPPER AIRWAYS
tion of their external intercostals and the
intercartilaginous portions of the internal intercostals.
Nose
This increases the AP diameter of the thorax. During
quiet inspiration, the epigastric area protrudes, then Noses vary in size and shape with individuals and na
the ribs swing up and out laterally, and finally the tionalities. Its framework is comprised of bony and
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2 Cardiopulmonary Anatomy 33
cartilaginous parts. The upper one third IS primarily are covered with a thin, yellow olfactory mucous
bony and contains the nasal bones, the fr ontal membrane that consists of bipolar nerve cells that are
processes of the maxillae and the nasal part of the olfactory in function. Only a portion of inspired air
frontal bone. Its lower two thirds are cartilaginous reaches the olfactory region to provide a sense of
and contain the septal, lateral, and major and minor smell. When people smell something specific, they
alar nasal cartilages. The nasal cavity is divided into sniff This action lifts the inspired air so that more of
right and left halves by the nasal septum. This cavity it comes in contact with the olfactory region.
extends from the nostrils to the posterior apertures of The anterior portion (vestibule) of the nasal cavity
the nose in the nasopharynx. The lateral walls of the (Figure 2-9) is lined with skin and coarse hairs (vibris
cavity are irregular as a result of projecting superior, sae) that entrap inhaled patticies. The rest of the cavity
middle, and inferior nasal chonchae. There is a mea and sinuses (with the exception of the olfactory region)
tus located beneath or lateral to each choncha through are lined with respiratory mucous membrane. This
which the sinuses drain. The chonchae increase the membrane is composed of pseudostratified columnar
sUlface area of the nose for maximum contact w ith ciliated epithelium (Figure 2-10). It contains goblet
inspired air. The superior chonchae and adjacent sep cells, as well as mucous and serous glands that produce
tal wall are referred to as the olfactory region. They secrete mucus and serous secretions. These secretions
FIGURE 2-9
Sagittal section of the head and neck.
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34 PART I Cardiopulmonary Function in Health and Disease
FIGURE 2-10
A, Pseudostrmified columnar ciliated B, Normal movements of cilia.
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2 Cardiopulmonary Anatomy 35
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36 PART I Cardiopulmonary Function in Health and Disease
approximate completely during phonation. However, nation to the right from the level of the cricoid carti
their closure can help protect the airway from aspira lage (see Figure 2-11, p. 35, and Figure 2-12). It trav
tion of foreign material. els behind the sternum into the thorax to the sternal
There are two main groups of muscles that control angle (opposite the fifth thoracic veltebra), where it
the opening and closing of the glottis-the abductors divides to form the right and left main-stem bronchi.
and adductors. The posterior cricoarytenoid muscle is The tracheal wall is strengthened by 16 to 20 horse
the most important muscle in the larynx, since it is the shoe-shaped cartilaginous rings. The open P3lts of the
only abductor of the vocal folds. It is vital for respira tracheal rings are completed by fibrous and elastic tis
tion. Contraction of this muscle separates the vocal sue and unstriated transverse muscle. This part of the
folds and widens the lumen of the glottis. There are ring faces the posterior and is very flexible. It indents
eight adductors of the vocal folds: (I) aryepiglottic, or curves inward during coughing. which increases
(2) thyroepiglottic, (3) thyroarytenoid, (4) vocalis, the velocity of expelled air. These cartilages lie hori
(5) cricothyroid, (6) lateral cricoarytenoid, (7) trans zontally one above the other, separated by narrow
verse arytenoid and (8) oblique arytenoid muscles. bands of connective tissue. The trachea is lengthened
Contraction of these muscles results in approximation during hyperextension of the head; swallowing, which
of the vocal cords and narrowing of the glottis. The raises the trachea; and inspiration, when the lungs ex
adductors of the cords are important in protecting the pand and pull the trachea downward. Its cross-sec
lower airways. Their contraction prevents fluids, food, tional area becomes smaller with contraction of the
and other substances from being aspirated. All the in unstriated transverse muscle fibers that complete the
trinsic laryngeal muscles are innervated by the recur tracheal rings.
rent laryngeal nerve (a branch of the vagus nerve) The mucous membrane of the trachea also con
with the exception of the cricothyroid muscle, which tains columnar ciliated epithelium and goblet cells.
is supplied by the external branch of the superior la Each ciliated epithelial eel I contains approximately
ryngeal nerve (also a branch of the vagus nerve). 275 cilia. These structures beat rapidly in a coordi
The mucous membrane of the larynx is continu nated and unidirectional manner, propelling a sheet
ous with that of the laryngopharynx above and the of mucus cephalad from the lower respiratory tract to
trachea below. It lines the cavity of the larynx and the pharynx, where it is swallowed or expectorated.
the structures found within. On the anterior surface The cilia beat in this layer of mucus with a strong,
and upper h a l f of the posterior surface of the forceful forward stroke, followed by a slow ineffec
epiglottis, and the vocal folds, the mucous mem tive backward stroke that returns the cilia to their
brane is stratified squamous epithelium. The rest of starting position. This propelling of mucus by the
the laryngeal mucosa is ciliated columnar epithe cilia (mucociliary escalator) is essential. When cilia
lium. The mucous membrane of the larynx has are paralyzed by smoke, alcohol, dehydration, anes
many mucous glands. They are especially numerous thesia, starvation, or hypoxia, mucus begins to accu
in the epiglottis, in front of the arytenoid cartilages mulate in distal, gravity-dependent airways, causing
and in the ventricles of the larynx. Some taste buds infiltrates and eventually localized areas of collapse
are also located on the epiglottis and irregularly referred to as atelectasis.
throughout the rest of the larynx. The number of mucus-containing goblet cells is
approximately equal to the number of ciliated epithe
lial cells. Reserve cells lie beneath the ciliated and
LOWER AIRWAYS
goblet cells. These reserve cells can differentiate into
either goblet cclls or ciliated cells. Beneath the re
Trachea
serve cells lie the gland cells. There are approxi
The trachea is a semi-rigid, cartilaginous tube approx mately 40 times more gland cells than goblet cells.
imately 10 to II cm long and 2.5 cm wide. It lies in Mucus is composed of 95% water, 2% glycoprotein,
front of the esophagus, descending with a slight incli I % carbohydrate, trace amounts of lipid, deoxyri
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2 Cardiopulmonary Anatomy 37
Apical
Apical
Posterior
Anterior
Anterior
??'fjfjl;ff?- Apical-posterior
Llnguta
Posterior
Anterior
Anterior
Posterior
FIGURE 2-12
Tracheobronchial tree (a three-quarter view, rotated toward the right side).
bonucleic acid (DNA), dead tissue celis, phagocytes, main-stem bronchus. The azygos vein arches over the
leukocytes, erythrocytes, and entrapped foreign parti right main-stem bronchus, the right pulmonary artery
cles. Mucus lines the airways from the trachea to the lies beneath. The right main-stem bronchus divides to
alveoli. Two separate layers have been observed-the form the right upper lobe bronchus, the right middle
sol layer, which lies on the mucosal surface and con lobe bronchus and the right lower lobe bronchus. The
tains high concentrations of water, and the gel layer, right upp e r l o b e d i v i d e s i n t o th r e e s e gm e n t al
which is more supelficial and more viscous because bronchi-apical, posterior, and anterior. The apical
of its lower concentration of water. bronchus runs almost vertically toward the apex of
The right main-stem bronchus appears to be an ex the lung. The posterior bronchus is directed posteri
tension of the trachea, being wider, shorter, and more orly in a horizontal direction, while the anterior
vertical than the left main-stem bronchus. Its greater bronchus is directed anteriorly in an almost horizon
width and more vertical course cause a majority of tal direction. The right middle lobe bronchus divides
aspirated foreign material to pass through the right about 10 mm below the right upper lobe bronchus
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38 PART I Cardiopulmonary Function in Health and Disease
and descends downward anterolateraJly. The right cross-sectional area increases because of the increased
lower lobe bronchus divides into five segmental number of divisions of the airways. The mucous
bronchi. The apical or superior bronchus runs almost membrane is essentially the same, with helical carti
horizontally, posteriorly. The medial or cardiac laginous plates and cilia becoming more sparse. These
bronchus descends downward medially toward the changes continue throughout the eighth to eleventh
heart. The anterior basal bronchus descends anteri generations, which are referred to as bronchioles.
orly. The lateral basal bronchus descends laterally The terminal bronchioles extend from the twelfth
and the posterior bronchus descends posteriorly. Note to the sixteenth generation. The diameter of these air
that each segment describes its position. ways is approximately I mm. Cartilage is no longer
The left main-stem bronchus is narrower and runs present to provide structural rigidity. The airways are
more horizontally than the right main-stem bronchus. embedded directly in the lung parenchyma, and it is
The aortic arch passes over it, while the esophagus, the elastic properties of this parenchyma that keep
descending aorta, and thoracic duct lie behind it. The these lower airways open. Strong helical muscle
left pulmonary artery lies anteriorly and above the bands are present, and their contraction forms longi
left main-s t e m b r o n c h u s . T h e l e f t m a i n-stem tudinal folds in the mucosa that sharply decrease the
bronchus has two major divisions-the left upper diameter of these airways. The epithelium of the ter
lobe bronchus and the left lower lobe bronchus. The minal bronchioles is cuboidal and no longer ciliated.
left upper lobe bronchus has three major segmental The cross-sectional area of the airways increases
bronchi. The anterior bronchus ascends at approxi sharply at this level, as the diameter of the terminal
mately a 45-degree angle. The apical-posterior bronchioles ceases to decrease as markedly with each
bronchus has two branches; one runs vertically and generation. All the airways to this level (I to 16 gen
the other posteriorly toward the apex of the left lung. erations) are considered conducting airways, because
The lingular bronchus descends anterolaterally, much their purpose is to transport gas to the respiratory
like the right middle lobe bronchus of the right lung. bronchioles and alveoli, where gas exchange occurs.
The right lower lobe bronchus divides into four seg The conducting airways receive their arterial blood
mental bronchi. The superior or apical bronchus runs from the bronchial circulation (branches of the de
posteriorly in a horizontal direction. The anterior scending aorta). Airways from below this point re
bronchus descends anteriorly. The lateral bronchus ceive their arterial blood from the pulmonary arteries.
descends laterally, while the posterior bronchus de The respiratory bronchioles extend from the sev
scends posteriorly. Again the segments describe their enteenth to the nineteenth generation. They are con
anatomical position. sidered a transitional zone between bronchioles and
The bronchi of the airways continue to divide until alveoli. Their walls contain cuboidal epithelium inter
there are approximately 23 generations (Table 2-1). spersed with some alveoli. The number of alveoli in
The main, lobar, and segmental bronchi are made up creases with each generation. The walls of the bron
of the first four generations. The walls contain U chioles are also buried in the lung parenchyma. The
shaped cartilage in the main bronchi. This cartilage airways depend on traction of this parenchyma to
becomes less well-defined and more irregularly maintain their lumen. Muscle bands are also present
shaped as the bronchi continue to divide. In the seg between alveoli.
mental bronchi the walls are formed by irregularly Alveolar ducts extend from the twentieth to the
shaped helical plates with bands of bronchial muscle. twenty-second generation. Their walls are composed
The mucous membrane of these airways is essentially entirely of alveoli, which are separated from one an
the same as in the trachea, but the cells become more other by their septae. Septae contain smooth muscle,
cuboidal in the lower divisions. elastic and collagen fibers, nerves, and capillaries.
The subsegmental bronchi extend from the fifth to The twenty-third generation of air passages is
the seventh generation. The diameter of these airways called alveolar sacs. They are essentially the same as
becomes progressively smaller, although the total alveolar ducts, except that they end as blind pouches.
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TABLE 2·1
MEAN
GENERATION DIAMETER AREA
(MEAN) NUMBER (MM) SUPPLIED CARTILAGE MUSCLE NUTRITION EMPLACEMENT EPITHELIUM
From Weibel MorphometlY of the human lung. New York, 1963, Springer. Used with permission.
w
(0
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40 PART I Cardiopulmonary Function in Health and Disease
(Actually, communication occurs between "blind Other cells located in the distal airways that are
pouches" in the form of the pores of Kohn's, which important in the defense of the lung are the lympho
are channels ill alveolar walls,. and Lambert's canals, cytes a n d p o l y m o r p h o n ucl ear l e ukoc ytes. I m
which are communications between bronchioles and murioglobulins (IgA, IgG, and IgM) in the blood
alveoli. These communications are thought to be re serum appear to enhance the engulfing activity of the
sponsible for the rapid spread of lung infection. They macrophages. There are two types of lymphocytes
also provide collateral ventilation to alveoli, whose found in the lung-the B-Iymphocyte and the T-Iym
bronchi are obstructed. Although this ventilation does phocyte. The B-lymphocytes produce gamma globu
little to arterialize blood, it does help prevent collapse lin antibodies to fight lung infections, whereas the T
of these alveoli.) Each alveolar sac contains approxi lymphoc ytes r e l e a s e a s u b s t a n c e that attracts
mately 17 alveoli. There are about 300 million alveoli macrophages to the site of the infection. The poly
in an adult man, 85% to 95% of which are covered morphonuclear leukocytes are important in engulfing
with pulmonary capillaries. Alveolar epithelium is and killing blood-borne gram-negative organisms.
composed of two cell types. Type I cells, squamous
pneumocytes, have broad thin extensions that cover
LUNGS
about 95'!c of the alveolar surface. Type II cells, the
granular pneumocytes, are more numerous than type Two lungs, each covered with its pleurae-the vis
I cells but occupy less than 5% of the alveolar sur ceral pleura and the parietal pleura-lie within the
face. This is because of their small, cuboidal shape. thoracic cavity. Each lung is attached to the heart and
These cells are responsible for the production of sur the trachea by its root and the pulmonary ligament. It
factant, a phospholipid that lines the alveoli. SUlfac is otherwise free in the thoracic cavity. The lungs are
tant keeps alveoli expanded by lowering their surface light, soft spongy organs, whose color darkens with
tension. Type II cells have been shown to be the pri age as they become impregnated with inhaled dust.
mary cells involved in repair of the alveolar epithe They are covered with the visceral pleura, a thin, glis
lium. (This has been shown in experiments where O2 tening serous membrane that covers all sUlfaces of the
toxicity was induced in monkeys and in numerous lung. The visceral pleura reflects and continues on the
other conditions where type I cells were destroyed.) med iasti num and inner thoracic wall, where it be
Type III cells, alveolar brush cells, are rare and are comes known as the parietal pleura. The space be
found only occasionally in humans. tween the two pleurae is minuscule and contains a
An additional type of cell, the alveolar negative pressure at all times, which helps keep the
macrophage, is found within the alveolus. These cells lungs inflated. A small amount of pleural fluid lubri
are thought to originate from stem cell precursors in cates the two pleurae as they slide over each other
the bone marrow and reach the lung through the during breathing. In disease, fluid, tumor cells. or air
blood stream. They are large, mononuclear, ameboid may invade the pleural space and collapse the under
cells that roam in the alveoli, alveolar ducts, and lying lung. Each lung ha an apex, base, arid three sur
alveolar sacs. They contain Iysosomes, which are ca faces (costal, medial, and diaphragmatic). There are
pable of killing engulfed bacteria. (Studies show also three borders (anterior, inferior, and posterior).
them to be most effective i n neutralizing inhaled Each lung is divided by fissures into separate lobes. In
gram-positive organisms.) They also engulf foreign the right lung the oblique fissure separates the lower
matter and are either transported to the lymphatic lobe from the middle, whereas the horizontal fissure
system or migrate to the terminal bronchioles where separates the upper lobe from the middle. The right
they attach themselves to the mucus. They are then lung is heavier and wider than the left lung. It is also
'
carried by the mucus to larger airways and eventually shorter because of the location of the right lobe of the
to the pharynx. Since cilia are not present below the Jiver. The left lung is divided into upper and lower
eleventh generation of air passages, clearance of mat lobes by the oblique fissure. It is longcr and thinner
ter and bacteria from these areas is largely dependent than the right lung, because the hem1 and pericardium
on the macrophages. are located in the left thorax. Numerous structures
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2 Cardiopulmonary Anatomy 41
enter the lung at the hilus, or root of the lung, includ rior angle of the scapula with the arm at rest. The in
ing the main-stem bronchus, the pulmonary artery, ferior border joins the posterior medial border of the
pulmonary veins, bronchial artelies and veins, nerves, lung 2 cm lateral to the tenth thoracic vertebra. The
and lymph vessels. The root, or hilus, of the lungs lies posterior medial border runs 2 cm lateral to the verte
opposite the bodies of the fifth, sixth, and seventh tho bral column from the seventh cervical vertebra to the
racic veltebrae. The lungs are connected to the upper tenth thoracic vertebra.
airways by the trachea and main-stem bronchi. The left lung is generally smaller than the right
and accommodates the position of the heart. The me
dial border on the anterior aspect runs from the ster
Surface markings
noclavicular joint to the middle of the sternal angle,
Surface markings of the lungs can be outlined over down the midline of the sternum to the fourth costal
the chest with a basic knowledge of bony landmarks cartilage. A lateral indentation of about 1 \/2 in forms
and gross anatomy of each lung (Table 2-2, and Fig the cardiac notch at the level of the fifth and sixth
ures 2-13, 2-14, and 2-15). The apices of both lungs costal cartilages. The courses of the inferior and me
extend 1 in above the clavicles at the medial ends. dial borders on the posterior aspect are similar in the
The anterior medial border of the right lung runs left and right lungs. In the left lung, however, the in
from the sternoclavicular joint, to the sternal angle ferior border crosses at the level of the tenth thoracic
downward to the xiphisternum. The inferior border vertebra, not the twelfth observed in the right lung.
runs from the xiphisternum laterally to the sixth rib in The position of the fissures of the lungs can be
the midclavicular line, the eighth rib in the midaxil outlined over the chest wall. In both lungs, the
lary line, and the tenth rib in the midscapular line. oblique fissure begins between the second to fourth
The midscapular line runs downward from the infe- thoracic vertebrae. This can be roughly estimated by
AnI. basal
BRONCHOPULMONARY
SURFACE MARKINGS SEGMENTS
FIGURE 2-13
Surface markings of the lungs (anterior aspect). The underlying bronchopulmonary segments are
also shown. (Printed with permission from Cherniak RM, Cherniack L: Respiration in health and
disease, ed 3, Philadelphia, 1983, WB Saunders.)
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42 PART I Cardiopulmonary Function in Health and Disease
TABLE 2-2
'This segmenl can be drained preferentially when the patient lies prone. Superiur segmenls abo called apical.
j" Medial basal segent has no direct exposure to the chest wall, therefore, cannot be directly auscultated. This segment preferenlially dr<lins
when the patienl is positioned for the left lateral basal s e gment because of the comparable angle ur its bronchus.
i: Lingula is not an anatomically uislinct area comp<lred with the right middle lobe; rather, it is Hn<llo mical l y pari of the left upper lobe.
Copyrighted Material
2 Cardiopulmonary Anatomy 43
-Xiphi
sternal
j u nc t io n
i
Mi d ax llary line
- 8th rib
SURFACE MARKINGS
FIGURE 2·14
SUlface markings of the lungs (lateral aspect). (Printed with permission from Cherniak RM,
Cherniack L: Respiration in health and disease, ed 3, Philadelphia, 1983, WB Saunders.)
}:o
T2(spine)
v
Apical
u
I
i
l \ .
�- Lat. basal
BRONCHOPULMONARY
SURFACE MARKINGS SEGMENTS
FIGURE 2·15
Surface markings of the lungs (posterior aspect). The underlying bronchopulmonary segments are
also shown. (Printed with permission from Cherniak RM, Cherniack L: Respiration in health and
disease, ed 3, Philadelphia, 1983, WB Saunders.)
Copyrighted Material
44 PART I Cardiopulmonary Function in Health and Disease
following a line continuous with the medial border heart is rotated to the left in the chest, resulting in the
of the abducted scapula, around the midaxillary line right side of the heart being foremost. Thus joining
at the fifth rib, and terminating at the sixth costal the two uppermost points outlines the level of the
cartilage anteriorly. The horizontal fissure of the atria and joining the two lower points represents the
right lung originates from the oblique fissure at the margin of the right ventricle.
level of about the fourth intercostal space in the mi The heart as a whole is freely movable within the
daxillary line, and courses medially and slightly up pericardial cavity, changing position during both con
ward over the fourth rib anteriorly. The left lung has traction and respiration. During contraction, the apex
no horizontal fissure. moves forward, strikes the chest and imparts the chest
and apex beat, which may be felt and seen. Abnormal
position of the apex beat can indicate cardiac enlarge
Bronchopulmonary Segments
ment or displacement. During breathing, the move
The bronchopulmonary segments lie within the ments of the diaphragm determine the position of the
three lobes of the right lung and the two lobes of the heart. This is because of the attachment of the central
left lung. There are 10 bronchopulmonary segments tendon of the diaphragm to the pericardium. Changes
on the right and eight on the left. Brief anatomic de in position during quiet breathing are hardly notice
scriptions of the position of each lobe are provided able, but with deep inspirations, the downwal'd excur
in Table 2-2, p. 42. Figure 2-13, p. 41, illustrates the sion of the diaphragm causes the heart to descend and
surface markings on the anterior view of the lungs rotate to the right. The opposite occurs during expira
and the position of the various bronchopulmonary tion. Pathology of the lungs can also change the posi
segments within the major anatomic divisions pro tion of the heart. Atelectasis shifts the heart to the
vided by the fissures. Figure 2-14, p. 43, shows same side. In tension pneumothorax, where air enters
some of these features from the lateral views. Figure the chest usually through an opening in the chest wall
2-15, p.43 illustrates the surface markings and bron and cannot escape, the positive pressure shifts the
chopulmonary segments of the posterior aspect of heart away from the side of the pathology.
the lungs. The heart is enclosed by the pericardium, whose
two surfaces can be visualized by considering the
heart as a fist that is plunged into a large balloon. The
HEART
outer surface, a tough fibrous membrane, is called the
The herut is a conical, hollow muscular pump enclosed fibrous pericardium. It encases the heart and the or
in a fibroserous sac, the pericardium. Its size is closely gans and terminations of the great vessels. This mem
related to body size and corresponds remarkably to the brane is so unyielding that when fluid accumulates
size of an individual's clenched fist. It is positioned in rapidly in the pericardial cavity, it can compress the
the center of the chest behind the lower half of the ster heart and impede venous return. When this occurs
num. The largest portion of the heart lies to the left of often, a window is cut in the pericardium, allowing
the midsternal line; the apex is found approximately 9 the fluid to escape. The inner surface, the serous peri
cm to the left in the fifth intercostal space. cardium, is a serous membrane that lines the fibrous
The surface markings of the heart can be traced by pericardium. Ten to 20 ml of clear pericardial fluid
joining four points over the anterior chest wall. On separates and moistens the two pericardial surfaces.
the right, the heart extends from the third to the sixth The pericardium with its fluid minimizes friction dur
costal caltilages at a distance of about to to 15 mm ing contraction. It also holds the heart in position and
from the sternum. On the left, the heart extends from prevents dilation. The serous pericardium consists of
the second costal cartilage to the fifth intercostal an outer layer, the parietal layer, and an inner layer
space 12 to 15 mm, and 9 cm from the left sternal the visceral layer, or epicardium.
border, respectively. Joining the two points on the The heart is divided into right and left halves by an
left side outlines the left atrium and ventricle. The obliquely placed longitudinal septum (Figure 2-16).
Copyrighted Material
2 Cardiopulmonary Anatomy 45
Pulmonary veins
Pulmonary veins
Atrium
Pulmonary valve
t <?t@iW._ Ventricle
..
FIGURE 2-16
Blood flow of the heart.
Each half has two chambers-the atrium, which re amount of work they perform. The ventricles do more
ceives blood from veins, and the ventricles, which work than the atria, and their walls are thicker. The
eject blood into the arteries. The sllperior vena cava, pressure in the aorta is higher than that in the pul
inferior vena cava, and intrinsic veins of the heart de monary trunk. This requires greater work from the
posit venous blood into the right atrium. Blood then left ventricle, so its walls are twice as thick as those
passes through the tricllspid valve to the right ventri of the right ventricle. The innermost layer, the endo
cle. The right ventticle projects the blood through the cardium, is the smooth endothelial lining of the inte
pulmonary valve into the pulmonary arteries, which rior of the heart. *
are the only arteries in the body containing deoxy
genated blood. Pulmonary veins return the blood to
Heart Valves
the left atrium and from there, it passes through the
mitral valve to the left ventricle. From the left ventri The four valves of the heart, although delicate in ap
cle it is ejected through the aortic valve into the main pearance, are designed to withstand repetitive clo
artery of the body-the aorta. sures a g a i n st h i g h pressures (se e F i g u r e 2-16)
The heart is divided into three layers-the epi (French, Criley, 1983). Normally, they operate for
cardium, myocardium, and endocardium. The outer more than 80 years without need of repair or replace
most layer, the epicardium, is visceral pericardium ment. The tricuspid and mitral valves function differ
and is often infiltrated with fat. The coronary blood en tly from the other valves of the h e art. Bei n g
vessels that nourish tile heart run in this layer before
entering the myocardium. The myocardium consists
"For additional information o f tbe clinical aspects o f heart
of cardiac muscle fibers. The thickness of the layers anatomy, referAnd reol i et ai, 1991; Goldberger, 1990;
10
of cardiac muscle fibers is directly proportional to the Sokolow, Mcilroy, Cheitlin, 1990; and Gray s Anatomy.
'
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46 PART I Cardiopulmonary Function in Health and Disease
located between the atria and ventricles, they must ef free edges of these valves project into the lumen of
fect a precise closure within a contracting cavity. the vessels. At the end of systole, blood in the aorta
During diastole, the two leaflets or cusps of the and pulmonary artery forces the cusps of the valves
mitral valve and the three cusps of the tricuspid valve shut. These valves are attached in such a manner
relax into the cavities of the ventricles, allowing that they cannot be everted into the ventricles by in
blood to flow between the two chambers. As the ven creased pressure in the vessels. During diastole, the
tricular chambers fill with blood, the cusps of the cusps support the column of blood filling the ven
valves are forced up into a closed position. Fibrous tricles. Contraction of the ventricles during systole
cords, the chordae tendinae, are located on the ven increases pressure within the ventricular chambers,
tricular surfaces of these cusps. These cords connect forcing the cusps to open and allow blood flow into
the cusps of the valve with the papillary muscles of the vessels.
the ventricular walls. As pressure builds in the ven The arterial supply of the heart muscle is derived
tricular chambers, contraction of these muscles pre from the right and left coronary arteries, which
vents the cusps from being forced up into the atria. arise from the aortic sinuses (Figure 2- 17). The left
Dysfunction or rupture of the chordae tendinae or the coronary artery (LCA) divides into the anterior de
papillary muscles may undermine the SUppOlt of one scending artery a n d the left circumflex artery.
or more valve cusps, producing regurgitation from These arteries supply most of the left ventricle, the
the ventricles to the atria. left atrium, most of the ventricular septum and, in
The pUlmonic and aortic valves are similar in ap 45% of people, the sinoatrial (SA) node. The right
pearance but the aortic cusps are slightly thicker coronary artery (RCA) supplies most of the right
than the pulmo ic cusps. Each valve has three fi ventricle, the atrioventricular (A V) node and, in
brous cusps, the bases of which are firmly attached 55% of people, the SA node. Infarction of these ar
to the root of the aorta or the pulmonary artery. The teries or their branches can thus cause interruption
----
Circumflex branch
FIGURE 2-17
Blood supply of the heart.
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2 Cardiopulmonary Anatomy 47
or cessation of the conduction system and death of node retains its position as pacer of the heru1 as long as
the myocardial muscle in the area supplied by the it generates impulses at a faster rate than any other pru1
artery. The severity of the infarction is dependent of the myocardium and as long as these impulses are
on the size of the artery and the importance of the rapidly conducted from the atria to the ventricles. Nor
area it supplies. mal impulse formation may be interrupted by vascular
The heart is drained by a number of veins. Most of lesions (occlusion of the coronary arteries) or by car
the veins of the heart enter the coronary sinus, which diac disease (pericarditis). The SA node is especiaUy
then empties into the right atrium. A small portion of susceptible to pericarditis and all other surface cardiac
veins, the thebesian veins, empty directly into the diseases because of its superticiaJ position immediately
right and left ventricles. beneath the epicardium.
The muscle fibers of the heart are self-excitatory,
which enables the heart to rhythmically and automati
Innervation
cally contract. The normal pacemaker of the heart is
Innervation of the heart involves a complex balance be the sinoatrial node located in the posterior wall of the
tween its intrinsic automaticity and extrinsic nerves right atrium. The concentric waves of excitation sent
(Figure 2-18). The SA and A V nodes provide the heart out by the SA node must travel through the A V node
with an inherent ability for spontaneous rhythmic initia to reach the ventricles. This node is located in the floor
tion of the cardiac impulse. The rate of this impulse for of the light atrium, just above the insertion of the tri
mation is regulated by the autonomic nervous system cuspid valve. Its main function is to cause a 0.04 sec
(ANS), which also influences other phases of the car ond delay in the atrioventricular transmissions. This
diac cycle. It controls the rate of spread of the excitation has two advantages. It postpones ventricular excitation
impulse and the contractility of both atria and ventricles. until the atria have had time to eject their contents into
The ANS extends its influence to the heaIl via the the ventricles. It also limits the number of signals that
vagus nerve (parasympathetic) and upper thoracic
nerves (sympathetic). These nerves mingle together
around the root and arch of the aorta near the tracheal
bifurcation, forming the cardiac plexus. Extensions
from the cardiac plexus richly supply the SA and A V
nodes. They are so well-mingled that scientists are un
able to determine which nerves supply which parts of
the heart. Stimulation of the sympathetic nervous sys
tem causes acceleration of the discharge rate in the SA
node, increase in A V nodal conduction, and increase
in the contractile force of both atrial and ventricular
muscles. Stimulation of the vagus nerve causes car
diac slowing and decreased A V nodal conduction.
Thus the parasympathetic system decelerates heart
rate and the sympathetic system accelerates heart rate.
Intrinsic innervation of the heart centers around the
SA node, which lies near the junction of the superior
vena cava and the right atrium. It is the normal pace
maker of the heart, sending concentric waves of excita
tion throughout the atrium. Without neural influence,
impulse formation from this node would be greater than
100 beats/minute. However, vagal influence decreases FIGURE 2-18
the impulse formation to 60-90 beats/minute. The SA Electrical conduction of the heart.
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48 PART I Cardiopulmonary Function in Health and Disease
can be transmitted by the A V node. The A V node also tion, the QRS complex indicates ventricular depolar
has its own inherent rhythmicity, firing at a much ization and the T-wave indicates ventricular repolar
slower rate than the SA node (40-60 beats/minute). Its ization. There is no wave indicating atrial repolariza
main pathology is a result of occlusion of the right tion, since this is embedded in the QRS complex
coronary artery, which supplies the AV node in 90% (Andreoli et aI,
of the cases. From the A V node arises a triangular of the Electtical Excitation of the Heart and ECG In
group of fibers known as the AV bundle or bundle of terpretation, Chapter II; Dubin, 1989; Marriott,
His. This bundle divides in the ventricular septum into Conover, 1989; and Wagner, 1994.
two branches-the left bundle branch and the right
bundle branch. Each of these bundles continues to di
SYSTEMIC CIRCULATION
vide into many fine strands that spread across the ven
tricles. At the end of the bundle's ramifications are The systemic vascular system is a complex series of
Purkinje's fibers, which are continuous with the car blood vessels throughout the entire body. It conveys
diac muscle. The waves of excitation pass through the nutrition and oxygen to all tissues of the body and car
bundle of His, down the bundle branches, and through ries away their waste products. The driving force for
the Purkinje fibers, which permeate the ventricles and this system is the heart. The vascular system can be
cause them to contract. This wave of depolarization considered to have two major components-the periph
gives rise to the normal P-QRS-T configuration of the eral and pulmonary circulations (Schlant et aI,
electrocardiogram (ECG) tracing (Figure 2- 19) (see Blood vessels are designed to forward oxygenated
Chapter II). The P-wave indicates atrial depolariza blood from the heart during systolic ejection of the
1 1
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Copyrighted Material
2 Cardiopulmonary Anatomy 49
left ventricle, perfuse the vascular beds commensu veins. These veins branch and become increasingly
rate with their metabolic needs and remove metabolic larger. Blood flow through the veins is largely depen
excreta. Anatomically, the proximal vessels have a dent on muscular or visceral action or pressures.
higher proportion of connective tissue and elastin to These pressures are intermittent and, were it not for
withstand high pulse pressures (e.g., the aorta, which double-cusp valves located within the veins, blood
carries blood to the head, viscera, and limbs). In addi would flow backward when the pressure ceases. In the
tion, potential energy is stored in the walls of the extremities, muscular contractions move blood into
larger vessels during systole. During diastole, the the trunk. In the pelvic and abdominal region, blood
elastic recoil of these vessels maintains the forward flow is dependent on intraabdominal pressure exceed
motion of the blood between ventricular systoles. The ing intrathoracic pressure. Blood flows through the
medium-size blood vessels have comparable propor trunk in veins that become increasingly larger until
tions of connective tissue and elastin to smooth mus they finally enter the supelior and inferior vena cavae.
cle. As the blood vessels become smaller, smooth
muscle predominates. The arterioles are primarily
PULMONARY CIRCULATION
smooth muscle and their diameter can alter signifi
cantly. They regulate the blood flow to regional tis The vena cavae empty directly into the right atrium.
sue beds and are also responsible for regulating total Blood flow from the right side of the heart through
peripheral resistance and systemic blood pressure. the lungs is known as the pulmonary circulation. The
They are called the stopcocks of the circulation. quantity of blood flowing through the pulmonary cir
Many factors (e.g., nervous impulses, hormonal stim culation is approximately equal to that flowing
ulation, drugs, oxygen, and carbon dioxide concentra through systemic circulation. Blood flows from the
tions) determine the degree of contraction of vascular right ventricle into the pulmonary artery, which di
smooth muscle and whether contraction occurs lo vides into right and left branches 4 cm from the ven
cally or throughout the entire body. tricle. These branches then separate, one going to
Arterioles branch to form the smallest vessels, the each lung, where they continue to divide into smaller
capillaries, which consist of a single layer of endothe arteries. The pulmonary arteries and arterioles are
lial cells forming lumen just large enough for the red much shorter, have thinner walls and larger diame
blood cells to roll along. The capillary bed is enormous; ters, and are more distensible than their systemic
its capacity far exceeding 5 L. Its network is finer and counterparts. This gives the pulmonary system a
denser in active tissue like muscle and brain, and less compliance as great as that of the systemic arterial
dense in less active tissue such as tendon. Gas ex system, thereby allowing the pulmonary arteries to
change occurs in the capillary bed, where the red blood accommodate the stroke volume output of the right
cells give up their oxygen, and blood plasma t:ransudes ventricle. Pulmonary vascular resistance and arterial
capillary walls, carrying nutrition to tissue. pressure are one sixth that of the systemic system
The microcirculation specifically consists of the (pulmonary arterial pressure is 20110 mm Hg com
metarterioles, the capillary bed, and the venules. The pared with 120/80 mm Hg systemically).
capillary wall is a semipermeable membrane that is re P u l m o n a r y c a p i l l a r i e s are s h o r t a n d a r i s e
sponsible for the transfer of oxygen, nutrients, and abruptly from much larger arterioles. They form a
waste between the circulation and the interstitial fluid dense network over the walls of the alveoli, making
(see Chapters 1 and 3). The capillary pores selectively a minimum distance over which gas exchange oc
allow different-size molecules to pass through them. curs. The pulmonary veins are also very short but
This is an essential feature that regulates the move have distensibility characteristics similar to those of
ment of fluid in and out of the intra- and extravascular the systemic system. Unlike systemic veins, these
compartments. This process is fundamental to main veins have no valves. Pulmonary veins act as a ca
taining and regulating normal hemodynamics. pacitance vessel, or a blood reservoir for the left
Capillaries form venules, which are the smallest atrium. Contraction of smooth muscle in the veins
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50 PART I Cardiopulmonal'Y Function in Health and Disease
makes the reservoir constrict. This increases blood ture of the bony the muscles of respiration as
volume in relation to the internal volume of the sociated with the chest wall and of the diaphragm.
vessels. The pulmonary veins become larger until The upper and lower
converge into two veins from each which scribed, a s well as the
then carry oxygenated blood to the left atrium. bronchial tree to the The lung
is defined anatomically in terms of dis
crete bronchopulmonary segments contained within
LYMPHATIC CIRCULATION
three major divisions of each The specific sur
The lymphatic circulation an additional face defined the lung fissures and the
route for fluid t o be returned from the interstitium landmarks for the bronchopulmonary segments were
to the systemic circulation, and thus has a central emphasized. The basic anatomy of the heart was de
role in the of interstitial fluid scribed. The structure of the and
the fluid that flows in the monary circulations was also Special ref
is interstitial fluid with similar composition t o erence was made to the lymphatic circulation and its
tissue fluid. T h e lymphatics remove excess fluid, central role in the regulation of capillary fluid
large ns, and other large molecules away namics. A detailed of cardiopulmonary
from the interstitial spaces. Although lit anatomy is fundamental to the base un
tle protein leaks from the capillaries into the sur the assessment and management of car
rounding tissue. the absence of its immediate re diopUlmonary dysfunction and impaired oxygen
moval is by physical therapists.
all areas of the body drain into a network
of channels. From the lower portion of the
REVIEW QUESTIONS
body, and left head and excess tissue fluid and
drain into the thoracic duct, which empties 1. Describe the thorax and its movements.
into the venous circulation at the junction of the left 2. Describe the respiratory muscles and their func
internal jugular vein and subclavian vein. tion.
from the right side of the head, arm, and 3. the of oxygen from the atmos
of the thorax drain into the lymph duct, phere to the alveolar capillary membrane.
which into the venous circulation at the junc 4. Describe the movement of oxygenated blood
tion of the internal vein and subclavian from the the heart to the pul
vein. Lymph from the lower of the body drains monary and circulations.
into the inguinal and abdominal lymphatic channels. 5. Describe the movement of deoxygenated blood
The pressure in the lymphatic is from the oerioherv back to the heart.
which helps to the interstitium 6. \Jrnnh"tlr circulation and
"dry." The lymph vessels are thin-walled with some its physiological
smooth muscle and thus can contract to propel their
contents. In addition, vessels have valves to
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and Disease (3rd ed,), Philadelphia: WB Saunders.
Copyrighted Material
2 Cardiopulmonary Anatomy 51
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cine, Philadelphia: WB Saunders, (1989), G r a y a n atomy (37th E d i n b u r gh:
Nunn, lE (1993), Applied respiratory physiology (4th ed.), Lon Churchill Livingsione,
don: BUllerworths,
Copyrighted Material
Cardiopulmonary Physiology
Elizabeth Dean
Lyn Hobson
This chapter reviews the basics of cardiopulmonary The act of breathing is a natural process to which
physiology. A thorough understanding of normal most of us give little thought. Unconsciously, it ad
physiology provides a basis for understanding the justs to various degrees of activity, maintaining opti
deficits of cardiopulmonary dysfunction and adapta mum arterial levels of POl and Peo2, whether we are
tion to it, and conducting a thorough assessment and resting or physically active. Sighing, yawning, hiccup
prescribing treatment (Bates, 1989; Berne and Levy, ing, laughing, and vo mitin g are all involuntary acts
1992; Clemente, 1985; Goldberger, 1990; Guyton, using respiratory muscles. Br athing is also under our
1991; Katz, 1992; Murray and Nadel, 1988; Nunn, voluntary control. A person can stop it temporarily by
1993, Sch31f and Cassidy, 1989; Schlant, Alexander, holding his or her breath or can increase it by rapidly
O'Rourke, Roberts, and Sonnenblick, 1994; Sokolow, panting until he or she faints (from cerebral vascular
McIlroy, and Cheitlin, 1990; and West, 1995. constriction as a result of a decrease in arterial Peo2).
53
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54 PART I Cardiopulmonary Function in Health and Disease
InhitJl/lon
S/imv/olion
:;::rJ
MEDULLA .
yj
jl pulmonory streICh receptors
ororecePlors
t ::"
', --. iralOry
-" Cells
Expir%ry -..- .-- ______
mo
Ce//s _ ca rotid and aortic cl1emoreceplors
I"
FIGURE 3-1
Control of breathing.
Exhalation is used in singing, speaking, coughing, and longed inspiratory gasps (apneustic breathing) occur.
blowing, whereas inspiration is used for sniffing and The pneumotaxic center is in the upper one third
sucking. Parturition, defecation, and the Valsalva ma of the pons. It maintains the normal pattern of respi
neuver are all performed while voluntarily holding our ration, balancing inspiration, and expiration by in
breath. These activities are directed by control centers hibiting either the apneustic center or the inspiratory
located in the brain. The centers integrate a multitude component of the medullary center.
of chemical, reflex, and physical stimuli before trans
mitting impulses to the respiratory muscles. The cere
Central Chemoreceptors
bral hemispheres control voluntary respiratory activ
i t y , whereas i n v oluntary respiratory activity i s These receptors are located on the ventral lateral sur
controlled b y centers located i n the pons and medulla faces of the upper medulla. They are bathed in the
(Figure 3-1). cerebrospinal fluid (CSF), which is separated from
blood by the blood-brain barrier. Although this bar
rier is relatively impermeable to hydrogen (H) and bi
Medullary and Pontine Respiratory Centers
carbonate (HC03) ions. Carbon dioxide (C02) diffuses
The respiratory center in the medulla is in the reticu through the barrier easily. Increased stimulation of
lar formation. It contains the minimum number of central chemoreceptors by a rising arterial PC02 re
neurons necessary for the basic sequence of inspira sults in increased rate and depth of ventilation.
tion and expiration. Although this center is capable of
maintaining some degree of respiratory activity, these
Peripheral Chemoreceptors
respirations are not normal in character.
The apneustic center is in the middle and lower These receptors are located in the carotid bodies,
pons. If uncontrolled by the pneumotaxic center, pro which lie in the bifurcations of the common carotid
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3 Cardiopulmonary Physiology 55
artery and in the aortic bodies located above and tory time. Receptors for this reflex are thought to
below the aortic arch. These bodies receive blood lie in the smooth muscle of airways from the tra
from small branches of the vessels on which they are chea to the bronchioles. In humans, it takes a lung
located. The receptors respond to an increase in arter inflation of more than 800 ml above func tional
ial Peo2 by increasing ventilation but are much less residual capacity to activate the reflex and delay the
important in their response to Peo2 than are the cen next breath.
tral chemoreceptors.
The main role of the peripheral chemoreceptors is
Cough Reflex
to respond to hypoxemia by increasing ventilation. If
arterial Peo2 is normal, the P02 must drop to 50 mm Mechanical or chemical stimuli to the larynx, trachea,
Hg before ventilation increases. A rising Pe02 causes carina, and lower bronchi result in a reflex cough and
the peripheral chemoreceptors to respond more quickly bronchoconstriction. The high velocity created by the
to a decreasing Po2. In some patients with severe lung cough sweeps mucus and other irritants up toward the
disease, this response to hypoxemia (the hypoxic pharynx (see Chapter 21).
drive) becomes very important. These patients often
have a permanently elevated Peo2 (C02 retention). The
Stretch Reflex
CSF in these patients compensates for a chronically el
evated arterial Peo2, by returning the pH of the CSF to The intercostal muscles and the diaphragm contain
near normal values. When these patients have lost the sensory muscle spindles that respond to elongation. A
ability to stimulate ventilation in response to an ele signal is sent to the spinal cord and anterior horn
vated Peo2, arterial hypoxemia becomes the major motor neurons. These neurons signal more muscle
stimulus to ventilation (hypoxic drive). fibers to contract (recruitment) and thus increase the
strength of the contraction. Theoretically, such a
stretch reflex may be useful when there is an increase
REFLEXES
in airway resistance or a decrease in lung compliance.
Stretching the ribs and the diaphragm may activate the
Hering-Breuer Reflex
stretch reflex and help the patient take a deep breath.
Hering and Breuer noted in 1868 that distention of The fundamental pathways of the stretch reflex are
anesthetized animal lungs caused a decrease in the shown in Figure 3-2. Research is needed, however,
frequency of inspiration and an increase in expira- to establish the therapeutic role of propriocepti ve
SPINDLE AFFERENT
MUSCLE SPINDLE
FIGURE 3-2
Stretch reflex.
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56 PART I Cardiopulmonary Function in Health and Disease
neurofacilitation techniques based on stretch reflex creasing alveolar pressure. The increased alveolar
theory in altering pulmonary funclion. pressure contributes to air flowing from the lungs.
Normally, expiration is a passive process reflecting
elastic recoil of the lung parenchyma.
Joint and Muscle Receptors
Peripheral joints and muscles of the limbs are believed Resistance to Breathing
to have receptors that respond to movement and en
hance ventilation in preparation for activity. Ventila Compliance
tion has also been shown to be stimulated by a similar The inner walls of the thorax, lined with parietal
reflex in humans and anesthetized animals in response pleura, and the parenchyma of the lung, enclosed in
to passive movement of the limbs. The precise path visceral pleura, lie in close proximity to one another.
ways for these reflexes have not been well-established. The pleurae are separated by a potential space con
taining a small amount of pleural fluid. Muscular
contraction of the intercostals and the diaphragm me
Mechanoreceptors
chanically enlarges the thorax. The lungs are en
Changes in systemic blood pressure cause correspond larged at this time because of their close proximity to
ing changes in pressure receptors in the carotid and the thorax. The healthy lung resists this enlargement
aortic sinuses. Increase in blood pressure causes me and tries to pull away from the chest wall. The ease
chanical distortion of the receptors in these sinuses, with which the lungs are inflated during inspiration is
producing reflex hypoventilation. Conversely, a reduc known as compliance and is defined as the volume
tion in blood pressure can result in hyperventilation. change per unit of pressure change. The normal lung
is very distensible or compliant. It can become more
rigid and less compliant in diseases that cause alveo
MECHANICAL FACTORS IN BREATHING
lar, interstitial or pleural fibrosis, and alveolar edema.
The flow of air into the lungs is a result of pressure Compliance increases with age and in emphysema.
differences between the lungs and the atmosphere. In The elastic recoil or compliance of the lung is also
normal breathing, for inspiration to occur, alveolar dependent on a special surface fluid caJled surfactant,
pressure must be less than atmospheric pressure. which lines the alveoli. This fluid increases compli
Muscular contraction of the respiratory muscles low ance by lowering the surface tension of the alveoli,
ers alveolar pressure and enlarges the thorax (Gold thereby reducing the muscular effort necessary to
man, j 979). The decreased pressure causes air to ventilate the lungs and keep them expanded. It is a
flow from the atmosphere into the lungs. Patients complex lipoprotein that is thought to be produced in
who are unable to create adequate negative pressure the type II alveolar cells (see Chapter 2). A decrease
may have to be mechanically ventilated. The ventila in surfactant causes the alveoli to collapse. Reex
tors create a positive pressure (greater than atmos panding these alveoli requires a tremendous amount
pheric pressure) that forces air into the lungs where of work on the part of the patient. The patient may
there is atmospheric pressure. The iron lung used dur become fatigued and need mechanical ventilation.
ing the poliomyelitis epidemic of the 1950s assisted This occurs in respiratory distress syndrome of the
ventilation using cycles of negative pressure to inflate premature infant (previously called hyaline mem
the lungs. brane disease) and in adult respiratory distress syn
Ex halation occurs when alveolar pressure is drome. In another disease, alveolar proteinosis, there
greater than atmospheric pressure. At the cessation of is excessive accumulation of protein in the alveolar
inspiration, the respiratory muscles return to their spaces. This may be because of excessive production
resting positions. The diaphragm rises, compressing of surfactant or deficient removal of surfactant by
the lungs and increasing alveolar pressure. As the in alveolar macrophages.
tercostals relax, the ribs drop back to their preinspira The elastic properties of the lung tend to collapse
tory position, further compressing the lungs and in the lung if not counterbalanced by external forces.
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3 Cardiopulmonary Physiology 57
FIGURE 3-3
Various relationships between the lungs and the thorax. At. The size the lungs would assume if
they were not acted on by the elastic recoil of the thoracic wall. A2, nOlmal size of lungs within the
thorax BI, The size the thorax would assume if it were not acted on by elastic recoil of the lungs.
B2, Normal position of the chest wall when acted on by elastic recoil of the lungs C, The normal
relationship of lung to thorax. 0, The positions assumed by the lung and thorax in a tension
pneumothorax.
The tissues of the thoracic wall also have elastic re posed by the usual elastic forces of the lungs, which
coil, which cause it to expand considerably if unop have been damaged by disease.
posed. These two forces oppose each other, keeping
the lungs expanded and the thoracic cage in a neutral
Pressure Volume Relationships
position. If these forces are interrupted (as in pneu
mothorax), the lung collapses and the thoracic wall Pressure volume curves help to define the elastic
expands (Figure 3-3). Similarly, the overinflated, bar properties of the chest wall and lungs (Cherniack,
rel-shaped chest of the patient with chronic obstruc Ch e r n i a ck, 1983; Co m r o e, Fo r s t e r, Dub o i s ,
tive pulmonary disease (COPD) is explained in part Briscoe, and Carlsen, 1986). The elasticity of the
by the elastic tension of the chest wall being unop respiratory system as a whole is the sum of its two
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58 PART I Cardiopulmonary Function in Health and Disease
.f . }
<l(
()
50 ture for breathing is most economicaL In other words,
Z
:::> volume result from relatively small
'1
-'
-' in pressure as noted from the sloDe of the
ff 30 ,U,C"ONAC
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3 Cardiopulmonary Physiology 59
( [) ,) tracheobronchial flow.
The airways are distensible and compressible, and
thus are susceptible to outside pressures. As these pres
sures compress the airways, they alter the airway resis
TURBULENT tance. Transmural pressure is the difference between
'-.=C)Jl 2,) the pressures in the airways and the pressures sur
, ,;:
rounding the airways. In erect humans, there is a
higher transmural pressure at the apices of the lungs
than at the bases. This expands the alveoli at the apices
relative to those at the bases. Although the alveoli in
the apices have a greater volume at end expiration, the
alveoli in the bases are better ventilated. This is be
cause the alveoli in the bases operate at lower trans
mural pressures and thus accommodate a greater vol
ume during inspiration than those at higher pressures.
Airway resistance decreases during inspiration as a
FIGURE 3-5 result of widening of the airways. During expiration,
The different types of airflow seen within the airways narrow, thus increasing resistance. The posi
tracheobronchial tree.
tive alveolar pressure that occurs during expiration
partially compresses the airways. If these airways have
lost their structural support as a result of disease, they
humans are divided into upper and lower airways (see may collapse and trap air distally (as in emphysema).
Chapter 2). The upper airways are responsible for 45%
of airway resistance. The resistance to airflow by the
VENTILATION
lower airways depends on many factors and is there
fore difficult to predict. The branching of the lower air Ventilation is the process by which air moves into the
ways is irregular, and the diameter of the lumen may lungs. The volume of air inhaled can be measured
vary because of external pressures, and contraction or with a spirometer. The various lung capacities and
relaxation of bronchial or bronchiolar smooth muscle. volumes are defined in chapter 8.
The lumen diameter may also decrease as a re.sult of Regional differences in ventilation exist through
mucosal congestion, edema, or mucus. Any of these out the lung. Studies using radioactive inert gas have
changes in the airway diameter may cause an increase shown that when the gas is inhaled by an individual
in airway resistance. Flow of air through these airways in the seated position, and measurements are taken
can be either laminar or turbulent (Figure 3-5). Lami with a radiation counter over the chest wall, radiation
nar flow is a streamlined flow where resistance occurs counts are greatest in the lower lung fields, interme
mainly between the sides of the tubes and the air mole diate in the midlung fields, and lowest in the upper
cules. It tends to be cone-shaped, with the molecules in lung fields. This effect is position or gravity depen
contact with the walls of the tubes moving more dent. In the supine position, the apices and bases are
slowly than the molecules in the middle of the tube. ventilated comparably, and the lowermost lung fields
Turbulent flow occurs when there are frequent molec are better ventilated than the uppermost lung fields.
ular collisions in addition to the resistance of the sides Similarly, in the lateral or sidelying position, the
of the tubes seen in laminar flow. This type of flow oc lower lung fields are preferentially ventilated com
curs at high flow rates and in airways where there are pared with the upper lung fields (see Chapter 18).
irregularities caused by mucus, exudate, tumor, and The causes of regional differences in ventilation
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60 PART I Cardiopulmonary Function in Health and Disease
can be explained in terms of the anatomy of the lung greater volume change in relation to resting volume
and mechanics of breathing. An intrapleural pressure which effects greater overall ventilation compared
gradient exists down the lung. In the upright position, with the upper lung fields. In summary, ventilation is
the intrapleural pressure tends to be more negative at favored in the lowermost lung fields regardless of the
the top of the lung, and becomes progressively less position of the body.
negative toward the bottom of the lung. This pressure
gradient is thought to reflect the weight of the sus
DIFFUSION
pended lung. The more negative intrapleural pressure
at the top of the lung results in relatively greater ex Once air has reached the alveoli, it must cross the
pansion of that area and a larger resting alveolar vol alveolar-capillary (A-C) membrane (Figure 3-6). The
ume. The expanding pressure in the bottom of the gases must cross through the surfactant lining, the
lung, however, is relatively small and hence has a alveolar epithelial membrane and the capillary en
smaller resting alveolar volume. This distinction be dothelial membrane. Oxygen has to travel further
tween the upper and lower lung fields is fundamental through a layer of plasma, the erythrocyte membrane
to understanding differences in regional ventilation. and intracellular fluid in the erythrocyte, until it en
The regional differences in resting alveolar volume counters a hemoglobin molecule. This distance is ac
should not be confused with regional differences in tually small in normal lungs, but in disease states, it
ventilation volume. Ventilation refers to volume may increase. The alveolar wall and the capillary
change as a function of resting volume. The relatively membrane often become thickened. Fluid, edema, or
higher resting volume in the upper lung fields renders exudate may separate the two membranes. These
it stiffer or less compliant compared with the low conditions are often first detected when arterial P02
lung volumes and greater compliance in the lower becomes chronically lower than normal. Oxygen dif
lung fields. The lower lung fields therefore exhibit a fuses slowly through the A-C membrane in compari-
".<
.rlfflllll".
FIGURE 3-6
The components of the alveolar-capillary membrane.
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3 Cardiopulmonary Physiology 61
son to CO2 diffusion. As a result, patients with diffu or poorly oxygenated lung areas. Although hypoxic
sion problems frequently have hypoxemia with a nor vasoconstriction may have an important role to im
mal Pe02. Sarcoidosis, berylliosis, asbestosis, sclero prove the efficiency of the lungs as a gas exchanger,
derma, and pulmonary edema are some diseases that this mechanism may be potentially deleterious to a
decrease the diffusing capacity of the gases. The ca patient who has reduced arterial oxygen pressure sec
pacity may also decrease in emphysema because of a ondary to pulmonary pathology.
decrease in surface area for gas exchange. The acid base balance of the blood also affects
pulmonary blood flow. A low blood pH or acidemia,
for example, potentiates pulmonary vasoconstriction.
PERFUSION
Thus impaired ventilatory function can disturb blood
Pelfusion of the lung refers to the blood flow of the gas composition and in turn, acid base balance. This
pulmonary circulation available for gas exchange. effect can be amplified because of the cyclic reaction
The pulmonary circulation operates at relatively low of pH on pulmonary vasoconstriction. Consideration
pressures compared with the systemic circulation. For of these basic physiologic mechanisms are tanta
this reason, the walls of the blood vessels in the pul mount to optimizing physical therapy intervention.
monary circulation are significantly thinner than
comparable vessels in the systemic circulation. Pul
Ventilation and Perfusion Matching
monary arterial pressure is low, because perfusion of
the top of the lung is the most distal area. Compared It is essential that ventilated areas of the lung are in
with the systemic circulation, there is little require contact with peIfused areas of the lung to effect nor
ment for significant regional differences in perfusion. mal gas exchange. Conditions that alter the ventila
Hydrostatic pressure has a significant effect on per tion or perfusion of part of the lung also affect the gas
fusion of the lowcr lobes. The hydrostatic pressure re exchange in that portion of the lung. Uneven ventila
flects the effect of gravity on the blood, tending to tion occurs where there is uneven compliance or un
favor peIfusion of the lower lung fields. This fact has even airway resistance in different parts of the lung.
been substantiated using radioactive tracers in the pul The lung is more compliant, that is, easier to inflate
monary circulation and measuring radiation counts at low lung volumes. In the upright position, the
over the lung fields. The nonuniformity of peIfusion apices have a higher resting volume because of a
reflects the interaction of alveolar, arterial, and venous more negative intrapleural pressure than the bases,
pressures down the lung. Normally, blood flow is de which renders the apices less compliant than the
termined by the arterial venous pressure gradient. In bases with relatively low resting volumes. Ventilation
the lungs, there are regional differences in alveolar as previously described is favored in the lower lung
pressure that can exert an effect on the arterial venous regions rather than the apices. Uneven airway resis
pressure gradient. For example, in the upper lung tance may result from airway narrowing (bron
fields, alveolar pressure approximates atmospheric choconstriction in asthma, mucous plugs, edema,
pressure, which overrides the arterial pressure and ef tumor,) or collapse from external pressures as with
fectively closes the pulmonary capillaries. In the lower tumors or emphysema). Uneven compliance may also
lung fields, the opposite occurs. The relatively low vol result from fibrosis, emphysema, pleural thickening,
ume of air in the alveoli is oveITidden by the greater effusions, or pulmonary edema.
capillary hydrostatic pressure. Thus the capillary pres Nonuniform peIfusion or blood flow can be a re
sure effectively overcomes the alveolar pressure. sult of gravity, regional differences in intrapleural
Pulmonary blood vessels constrict in response to pressure, regional changes in alveolar pressure, and
low arterial pressures of oxygen. This is termed hy obstruction or blockage of part of the pulmonary cir
poxic vasoconstriction. Hypoxic vasoconstriction in culation. Gravity increases blood flow in the depen
the lung is believed to serve as an adaptive mecha dent portions of the lung and decreases it in the non
nism for diverting blood away from underventilated dependent portions of the lung. Regional differences
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62 PART [ Cardiopulmonary Function in Health and Disease
ZONE I
ZONEm
FIGURE 3-7
The perfusion of the lung is dependent on posture. In the
upright position three areas can be seen. Zone III has
perfusion in excess of ventilation, in Zone II perfusion and
ventilation are fairly equal and in Zone I ventilation occurs
in excess of perfusion.
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3 CardiopuLmonary Physiology 63
FIGURE 3-9
The effect of positioning on perfusion of the lung. Note that gravity-dependent segments have the
greatest amount of perfusion.
FIGURE 3-10
A, Normal alveolus. B, Dead space. C, Shunt.
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64 PART I Cardiopulmonary Function in Healt.h and Disease
amount of perfusion and ventilation. This occurs to ues of POl and PC02. Therefore the lungs must be able
ward the base of the lungs in erect humans. Changes to supply four parts ventilation to about five parts
in posture cause changes in perfusion and ventilation. perfusion. When the ratio is not uniform throughout
Generally, greater air exchange occurs toward the the lung, the arterial blood cannot contain normal
gravity-dependent areas. In side lying, there is greater blood gas values. Regions with low ratios (perfusion
gas exchange in the dependent lung (Figure 3-9). in excess of ventilation) act as a shunt, while regions
In normal lungs, there is an optimal ratio or with high ratios (ventilation in excess of perfusion)
matching of gas and blood. This ratio of ventilation act as dead space (Figure 3-10). Hypoxemia results
to perfusion is 0.8 to maintain normal blood gas val- if regions of abnormal V:Q ratio predominate. An
\\tntilation-Perfusion Ratio
o 2 4
Apex v
Q
Blood flow
Base
FIGURE 3-11
The effect of gravity on ventilation, perfusion and ventilation-perfusion matching (V/Q ratio).
PO? ,W
pco ALVEOLAR
DEAD SPACE
.L
' _ _ _ _
Apex t=oo
Po, '
A _ _
L
pco
NORMAL
-
*::::1:;
:::'2::
'd----
SHUNT
Base *=0
FIGURE 3-12
Schemata showing the effect of gravity on ventilation and perfusion down the upright lung.
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3 Cardiopulmonary Physiology 65
. b .. ....... .
gional differences in ventilation and perfusion in the
E •
.. .. :: .... . .
S 80 .
... .. . .
DIASTOLE
a:
CARDIAC REflEXES ::s E 120
::J
Ow
The heart behaves automatically, thus is termed a a: 80
f-::J
functional syncytium. Three primary reflexes enable z..J
wO
» 40
the heart to increase stroke volume and cardiac out
put with moment-to-moment changes in myocardial HEART __ __ -fl ________
tegrated function of these three reflexes ensures that active rapid filling. Note relationship of ventricular pressure
cardiac output adjusts as de mands on the heart and volume. (a) closure of the atrioventricular valves;
change, that is in health, primarily in response to ex (b) opening of the semilunar valves; (c) closure of the
ercise, body position and emotional stress. semilunar valves; (d) opening of the atrioventricular valves.
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66 PART I Cardiopulmonary Function in Health and Disease
Ventricular systole normally has three phases: isovol Pulmonic and Aortic Valves Open
umctric contraction period, and
a slower
three phases: passive
period. Ventricular diastole also has
diastasis (a
t
Diastolic Filling
S2. During inspiration, intrathoracic pressure becomes
more venous return and
increase, hence pulmonary
heart volume
is prolonged in this
l
Myocardial Depolarization
and closure of the pulmonary valve is de-
Other variations in splitting of occur with FIGURE 3-14
pathology. The presence of a third (S3) or fourth The sequence of pressure in the hearl the
cardiac
heart sound is usually considered abnormal. is usu
associated with the phase, and
with the active rapid-filling phase.
heart are responsible for the and of the
valves. Coordinated valve opening and closure are im
Volume and Pressure Changes
portant in promoting the forward movement of blood
Changes in the ventricular volume curve and aortic and mechanical of the heart
pressure wave reflect in atrial and ventricular pump resulting from valvular of blood
pressure during and diastole (Ganong, 1993; ventricular contraction. of blood
Guyton, 1991). The sequence of events appears in a in the retrograde direction gives rise to heart murmurs
tlow chart in Figure 3-14. Pressure gradients within the audible on auscultation of the heart (Goldberger. 1990).
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3 Cardiopulmonary Physiology 67
Mean forces moving fluid out of capillary TRANSPORT OF OXYGEN BY THE BLOOD
Mean capillary pressure 17.0
Once oxygen reaches the blood, it rapidly combines
Negative interstitial pressure 6.3
Oncotic interstitial pressure 5.0 with hemoglobin to form oxyhemoglobin (West,
TOTAL OUTWARD PRESSURE 28.3 1995). A small proportion of oxygen is dissolved in
the plasma. The use of the hemoglobin molecule as
Mean forces moving fluid into capillary
an oxygen carrier allows for greater availability and
Plasma oncotic pressure 28.0
efficiency of oxygen delivery to the tissues in re
TOTAL INWARD PRESSURE 28.0
sponse to changes in metabolism. Saturation of the
OUTW ARD PRESSURE - INW ARD oxygen-carrying sites on the hemoglobin molecule is
PRESSURE NET OUTW ARD PRESSURE 0.3
curvilinearly related to the partial pressure of oxygen
=
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68 PART I Cardiopulmonary Function in Health and Disease
ARTERIAL OXYGENATION
75
C\J
0
Z
0
i=
«
0:::
::J
(f)
20 27 40 60 80 100
PARTIAL PRESSURE 02
FIGURE 3-15
Different conditions can increase or decrease he Anemia (reduced red blood cell count and hemo
moglobin affinity for oxygen and thereby cause a shift globin) and polycythemia (excess red blood cells and
in the oxyhemoglobin dissociation curve (West, 1995) hemoglobin) produce changes in oxygen content of
(Figure 3-15). A shift to the right results in decreased the blood as well as saturation. Anemia shifts the
oxygen affinity and greater dissociation of oxygen and curve to the right and lowers the maximal saturation
hemoglobin. In this instance, for any given partial achievable. Polycythemia has the opposite effect. The
pressure of oxygen, there is a lower saturation than curve is shifted to the left and maximal saturation ap
normal. This means that there is more oxygen avail proaches 100%.
able to the tissues. Shifts in the curve to the right
occur with increasing concentration of hydrogen ions
TRANSPORT OF CARBON DIOXIDE
(i.e., decreasing pH), increasing Peo2, increasing tem
peratures, and increasing levels of 2,3-DPG (diphos CO2 is an acid produced by cells as a result of cell
phoglycerate), a byproduct of red blood cell metabo metabolism. It is carried in various forms by venous
l i s m . W e s t ( 19 9 5 ) s u g g e s t s , "A simple way t o blood to the lungs, where it is eliminated. Most of the
remember these shifts i s that an exercising muscle (in CO2 added to plasma diffuses into the red blood cells,
creased metabolic demand), is acid, hypercarbic, (hy where it is buffered and returned to the plasma to be
percapnic) and hot, and it benefits from increased un carried to the lungs. The buffering mechanism is so
.
loading of oxygen from its capillaries." effective that large changes in dissolved CO2 can
A shift of the curve to the left results in increased occur with small changes in blood pH.
oxygen affinity. Thus for any given partial pressure The transport of CO2 has an important role in the
of oxygen, there is a higher saturation than normal. acid-base status of the blood and maintenance of nor
This means that there is less oxygen available to the mal homeostasis (Comroe, Forster, Dubois, Briscoe,
tissues. This occurs in alkalemia, hypothermia, and and Carlsen, 1986). The lung excretes 10,000 mEg of
decreased 2,3-DPG. carbonic acid per day. (Carbonic acid is broken down
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3 Cardiopulmonary Physiology 69
into water and CO2. The CO2 is buffered and elimi globin dissociation ensures adequate oxygen delivery
nated through the lungs.) The kidney can excrete only to the tissues once oxygen has diffused through the
100 mEq per day of acids. Therefore alterations in alveolar capillary membrane into the circulation.
alveolar ventilation can have profound effects on the Transport of CO2 and its buffering mechanisms are
body's acid-base status. A decrease in the lung's abil central to acid base balance and normal homeostasis.
ity to ventilate causes a sharp rise in Peo2 and a drop
in pH. This causes an acute respiratory acidosis. If
REVIEW QUESTIONS
this change occurs gradually, the pH will remain
within normal limits while the Peo2 is elevated. This I. Describe the control of breathing.
is known as a compensated respiratory acidosis. Hy 2. Explain respiratory mechanics with respect to
perventilation or excessive ventilation causes rapid airway resistance and lung compliance.
elimination of C02 from the blood. This results in a 3. Describe the distributions of ventilation, perfu
decreased Peo2 and an increased pH and is known as sion and diffusion.
an acute respiratory alkalosis. Again, if the change 4. Explain the determinants of ventilation and per
occurs gradually, the pH remains within normal lim fusion matching.
its even though the Peol is decreased. This is a com S. Describe electromechanical coupling in the heart.
pensated respiratory alkalosis. 6. Describe oxyhemoglobin dissociation and the
oxyhemoglobin dissociation curve.
SUMMARY
REFERENCES
This chapter presented an overview of cardiopul
monary physiology with respect to breathing control, Andreoli, K.G., Fowkes, V.K., Zipes, D .P., & Wallace, A.G.
both central and peripheral mechanisms such as mus (Eds.). (1991). Comprehensive cardiac care (7th ed.). SI Louis:
Mosby.
cle, joint, and lung and chest wall stretch receptors, in
Bates, D.V. (1989). Respiratory Junction ill disease. (3rd ed.).
volved with the regulation of respiration. Mechanical
Philadelphia: WB Saunders.
factors of breathing, chest wall and lung compliance, Berne, R.M., & Levy, M.N. (1992). Cardiovascular physiology
and airway resistance are described. The elastic prop (6th ed.). St Louis: CV Mosby.
erties of the respiratory system, that is, chest wall and Burrows, B., Knudson, R.J., Quan, SF, & Keitel, L.J. (1983). Res
piratory disorders: A pathophysiologic approach (2nd ed.).
lungs, are ret1ected in the pressure volume relaxation
Chicago: Year Book Medical.
curve. This curve has important implications for the
Cherniack, R.M., & Cherniack, L. (1983). Respiration in health
clinical presentation of the patient with cardiopul and disease ( 3rd ed.). Philadelphia : WB Saunders.
monary dysfunction, and in particular, the efficiency Clemente, C.D. (Ed.). (1985). Anatomy oj the human body (30th
and energy requirement of the respiratory system. ed.). Philadelphia: Lea and Febiger.
Comroe, J.H., Jr., Forster, R.E., Il, Dubois, A.B., Briscoe, W.A., &
Ventilation and pelfusion matching is the basis of gas
Carlsen, E. (1986). The lung; Clinical physiology and pul
exchange and the adequacy of lung function. Many
monary Junction tests (3rd ed.). Chicago: Year Book Medical.
factors in addition to disease, however, can affect ven Dubin, D. (1989). Rapid interpretation oj EKGs (4th ed.). Tampa,
tilation and perfusion matching, including age, body FL: Cover.
position, breathing at low lung volumes and smoking French, W.G., & Criley, J.M. (Eds.). (1983). Practical cardiology:
Ischemic and valvular heart disease. New York: John Wiley
history. The relationship of such factors are discussed.
and Sons.
The purpose of the heart is to provide an adequate car
Ganong, W. F. (1993). Review oj medical physiology (16th ed.).
diac output, hence, adequate oxygen delivery to the Los Altos: Lange Medical Publications.
vital organs and peripheral tissues. The optimal cou Goldberger, E. (1990). Essentials oj clinical cardiology. Philadel
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70 PART I Cardiopulmonary Function in Health and Disease
Guyton, A,C, (l99J), Textbook of medical physiology. (8th ed,j, Sokolow, M., McIlroy, M.B" & Cheitlin, M.D. (1990), Clinical
Philadelphia: WB Saunders. cardiology (5th 00.), Norwalk: Appleton & Lange.
Katz, A,M, (1992). Physiology of Ihe hearl (2nd ed.) New York: Wagner, G.S. (J994), Marrioll's practical electrocardiography
Raven Press. (9th ed,). Baltimore: Williams and Wilkins.
Murray, IF, & Nadel, l.A. (1988). Textbook of respiratory medi West, J.B. (1995). Respiratory physiology-The essen/ials (5th
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. ed.). Baltimore: Williams and Wilkins.
Nunn, J.F ([993). Applied respiralory physiology (4th ed,). Lon West, 1.B. ([992), Pulmonary pathophysiology: The essenlials (4th
don: Butterworths. 00.). Baltimore: Williams and Wilkins.
Scharf, S,M" & Cassidy S.S, (Eds,), (1989). Hearl-lung interac West, .l.B. (1991). Best and Taylor's physiological basis of med
tions in health and disease. New York: Marcel-Dekker, Inc. ical praclice (12th ed.J. Baltimore: Williams and Wilkins.
Schlant, R,C., Alexander, R.W., O'Rourke, R.A., Robens, R., &
Sonnenblick, E. H. (Eds.J. (1994). Hurst's lite heart: Arleries
and veins (8th ed.J. New York: McGraw-Hill.
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Cardiopulmonary Pathophysiology
Willy E. Hammon
Scott Hasson
INTRODUCTION
formance. The parameters affected by CAD can be the
The first part of this chapter, beginning with obstruc volume of blood pumped and the heart rate. The
tive lung disease, describes the pathophysiology of major purposes of this portion of the chapter are to de
chronic pulmonary disease. Chronic pulmonary dis scribe the etiologic factors of clinical syndromes asso
ease can be categorized broadly into obstructive and ciated with CAD, briefly describe medical treatment,
restrictive disorders. and discuss issues of prognosis.
Obstructive disorders are characterized by a de
creased rate of airflow during expiration (as a result
OBSTRUCTIVE LUNG DISEASE
of increased airway resistance). Restrictive disorders
are conditions in which the inspiratory capacity of the Several abbreviations can be found in the literature
lungs is restricted to less than the predicted normal. for a pulmonary disorder characterized by increased
Overlap between the two categories does exist. airway resistance, particularly noticeable by a pro
The second part of this chapter, beginning with longed forced expiration. Some of these are chronic
coronary artery disease (CAD), describes the patho obstructive pulmonary disease (COPD), chronic ob
physiology of cardiovascular disease. Cardiovascular structive airway disease (COAD), chronic airway ob
disease is also known primarily as CAD, and is mani struction (CAO), and chronic obstructive lung disease
fested in various clinical syndromes. CAD is an ather (COLD) (Fishman, 1988).
osclerotic process that occurs in the right and left The first part of this chapter describes chronic
coronary aJ1eries, which ultimately affects heart per- bronchitis, emphysema, asthma, and bronchiectasis
71
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72 PART I Cardiopulmonary Function in Health and Disease
individually. With the possible exception of asthma susceptible to rcspiratory infections, and it takes them
and bronchiectasis, however, it is unusual in the clini longcr to recovcr from these infections. In addition, the
cal setting to find a patient with only one of these con ilTitation of smoke in the tracheobronchial trec causes
ditions. Most patients have some combination of bronchoconstriction. Although smoking is the most
chronic bronchitis, emphysema, and asthma, and in common cause of chronic bronchitis, other agents that
this chapter, these individuals are referred to as having have been implicated are air pollution, bronchial infec
COPD. These patients have intermittent episodes of tions, and certain occupations.
wheezing, along with a variable degree of chronic These patients are referred to as "blue bloaters,"
bronchitis and emphysema (Hodgkin, 1975). Radio because they usually have stocky body build and are
logically, they may have hyperinfiated lungs, flattened "blue" as a result of hypoxemia (Dornhorst, 1955;
diaphragms, and an enlarged right ventricle as a result Filley et ai, 1968; Fishman, 1988; Nash, Briscoe,
of increased pulmonary artery pressure. Other findings and COUl·nand, 1965. Although many of these pa
vary from patient to patient, depending on the predom tients have a high arterial partial pressure of carbon
inant disease process contributing to their COPD. dioxide (Pac02), the pH is normalized by renal re
COPD is very common. In 1994 the American tention of bicarbonate (HC03). In the patient with
Lung Association (ALA) estimated that 14.2 million chronic bronchitis, bone marrow tries to compensate
Americans have COPD. In the United States alone, for chronic hypoxemia by increased production of
health care costs for COPD exceed $7.6 billion annu red blood cells, leading to p olycythemia (Snider,
ally. Deaths from COPD numbered more than 85,000 Faling, and Rennard, 1994). Polycythemia, in turn,
in 1991; it is the fourth leading cause of death in the makes the blood more viscous, forcing the heart to
United States. work even harder to pump it. Long-term hypoxemia
leads to increased pulmonary artery pressure and
right ventricular hypertrophy.
Chronic Bronchitis
Individuals with bronchitis often expectorate mu
Chronic bronchitis is a disease characterized by a coid brownish-colored sputum. In an exacerbation,
cough producing sputum for at least 3 months and for 2 usually from infection, they have an even greater
consecutive years (American Thoracic Society, 1962). amount of purulent sputum. Ventilation-perfusion ab
Pathologically, there is an increase in the size of normalities are common, which increase hypoxemia
the tracheobronchial mucous glands (increased Reid and Paco2 retention (Rochester and Brown, 1976).
index) and goblet cell hyperplasia (Mitchell, 1968; The respiratory rate increases, as does the use of ac
Reid, 1960; Stoller and Wiedemann, 1990). Mucous cessory muscles. The resultant increased work of
cell metaplasia of bronchial epithelium results in a breathing requires greater oxygen consumption by
decreased number of cilia. Ciliary dysfunction and these muscles, with a greater production of carbon
disruption of the continuity of the mucous blanket are dioxide (C02) than the respiratory system can ade
common. In the peripheral airways, bronchiolitis, quately meet. This contributes to a further drop in the
bronchiolar narrowing, and increased amounts of arterial partial pressure of oxygen (Pao2) and a rise in
mucus are observed (Cosio, 1978; Wright, 1992). Paco2. The hypoxemia and acidemia increase pul
The cause of chronic bronchitis is believed to be re monary vessel constriction, which raises pulmonary
lated to long-term in-itation of the tracheobronchial tree. artery pressure and ultimately leads to right heart fail
The most common cause of irritation is cigarette smok ure (cor pulmonale).
ing (US Surgeon General, 1984). Inhaled cigarette In the following example, a patient is admitted to
smoke stimulates the goblet cells and mucous glands to the hospital with an exacerbation of chronic bronchi
secrete more mucus. This smoke also inhibits ciliary tis and presents the following picture: he is of stocky
action. The hypersecretion of mucus and impaired cilia body build, his color is dusky, and he breathes with
lead to a cllronic productive cough. The fact that smok moderate-to-marked use of the respiratory accessory
ers secrete an abnormal amount of mucus makes them muscles, depending on the degree of respiratory dis
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4 Cardiopulmonary Pathophysiology 73
Alveoli
A ___
FIGURE 4-1
A, Panlobular is characterized by a destructive enlargement of the alveoli, B, A nonnal
respiratory bronchiole and alveoli. Centrilobular emphysema is characterized a selective
and destmction of the bronchiole.
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74 PART I Cardiopulmonary Function in Health and Disease
characterized by destructive enlargement of the alve (Figure 4-2) (Reid, 1967; Thurlbeck, 1991; Thurlbeck,
oli, distal to the terminal bronchiole (Figure 4-1). It 1976). It is thought that bullae develop from a coales
most often involves the lower lobes. This type of em cence of adjacent areas of emphysema or an obstruc
physema is also found in subjects that have alphaJ tion of the conducting airways that permits the flow of
antitripsin deficiency. Airway obstruction in these in air into the alveoli during inspiration but does not
dividuals is caused by loss of lung elastic recoil or allow air to flow out again during expiration. This
radial traction on the bronchioles. When individuals causes the alveoli to become hyperinflated and even
with normal lungs inhale, the airways are stretched tually leads to destruction of the alveolar walls with a
open by the enlarging elastic lung, and during exhala resultant enlarged air space in the lung parenchyma.
tion the airways are narrowed as a result of the de These bullae can be more than 10 cm in diameter, and
creasing stretch of the lung. However, the lungs of by compression, can compromise the function of the
patients with panlobular emphysema have decreased remaining lung tissue (Figure 4-3). If this happens,
elasticity because of disruption and destruction of surgical intervention to remove the bulla is often nec
surrounding alveolar walls. This in turn leaves the essary. Pneumothorax, a serious complication, can re
bronchiole unsupported and vulnerable to collapse sult from the rupture of one of these bullae.
during exhalation. The emphysema patient's most common com
Bullae, emphysematous spaces larger than I cm in plaint is dyspnea. Physically, these patients appear
diameter, may be found in patients with emphysema thin and have an increased anteroposterior chest di-
FIGURE 4-2
A, AP chest film reveals bullous emphysema with multiple, thin, rounded fibrotic lucencies. B, The
spot film bronchogram of the left midlung field shows intact bronchi and distal emphysematous blebs.
(Courtesy of T. H. Johnson, M.D.)
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4 Cardiopulmonary Pathophysiology 75
ameter. Typically, they breathe using the accessory heart (Figure 4-4). Pulmonary function tests show a
muscles of inspiration. These patients are often seen decreased vital capacity, FEY" maximum voluntary
leaning forward, resting their forearms on their knees ventilation and a greatly reduced diffusing capacity.
or sitting with their arms extended at their sides and The total lung capacity is increased, while the resid
pushing down against the bed or chair to elevate their ual volume and functional residual capacity are even
shoulders and improve the effectiveness of the acces more increased. Arterial blood gases reflect a mildly
sory muscles of inspiration. They may breathe or moderately lowered Pao2, a normal or slightly
through pursed lips during the expiratory phase of raised Pacol and a normal pH. These patients, unlike
breathing. These patients have been referred to as patients with chronic bronchitis, normally will de
"pink puffers" because of the increased respiratory velop heart failure in the end stage of the disease
work they must do to maintain relatively normal (Figure 4-5).
blood gases (Dornhorst, 1955; Filley et aI, 1968; Treatment of progressive emphysema that requires
Fishman, 1988; Nash, Briscoe, and Cournand, 1965). hospitalization often includes IY fluids, antibiotics,
On auscultation, decreased breath sounds can be and low-flow oxygen (Snider, Faling, and Rennard,
noted throughout most or all of the lung fields. Radi 1994). Some of these patients also receive bron
ologically, the emphysema patient has overinflated chodilators, corticosteroids, diuretics, and digitalis.
lungs, a flattened diaphragm, and a small, elongated Pursed-lip breathing can relieve dyspnea and improve
FIGURE 4-3
A, AP and B, lateral views of the chest of a patient with advanced bullous emphysematous changes.
Note the bullae in the upper lung fields. The lateral film reveals an increased A-P diameter of the thorax,
flattening of the diaphragms and in increased anterior clear space. (Collrtesy of T. H. Johnson, M.D.)
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76 PART I Cardiopulmonary Function in Health and Disease
FIGURE 4-4
A, AP chest film reveals the increased lucency of lung fields and flattening of the diaphragm of
emphysema. The vascular structures are crowded mediaHy. B, Lateral chest film reveals an
increased AP diameter and flattening of the diaphragms. There is an increase in the anterior clear
space. These are all findings of emphysema. (Courtesy of T. H. Johnson, M.D.)
arterial blood gasses (Muller, Petty, and Filley, 1970; these and other factors in producing emphysema is
Petty and Guthrie, 1974). still not well understood.
The cause of emphysema is uncel1ain. It is known
Prognosis of chronic bronchitis and emphysema
that the incidence of emphysema increases with age. It
is most often found in chronic bronchitics, and there is Chronic bronchitis and emphysema are marked by a
no question that emphysema is more prevalent in cig progressive loss of lung function. At the end of 5
arette smokers than in nonsmokers (US Surgeon Gen years, patients with COPD have a death rate four to
eral, 1984). The risk of developing COPD is 30 times five times greater than the normal expected value.
greater in smokers than nonsmokers (Fielding, 1985). Death rates reported by various studies depend on the
There also seems to be an hereditary factor, evident in method of selection of patients, types of diagnostic
the severe panlobular emphysema that patients with tests and other criteria (Anthonisen, 1989; Bousky et
an alpha,-antitrypsin deficiency develop relatively ai, 1964; Kanner et ai, 1983; Kanner and Renzetti,
early in life, even though they m a y never h ave 1984). One study reported a 3-year overall mortality
smoked (Eriksson, 1965; Tobin, Cook, and Hutchin rate of 23%, with patient age and the initial FEY I
son, 1983). Repeated lower respiratory tract infections value being the most accurate predictors of death
may also play a role. However, the interrelationship of (Anthonisen, Wright, and Hodgkin, 1986). In general,
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4 Cardiopulmonary Pathophysiology 77
Asthma
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78 PART I Cardiopulmonary Function in Health and Disease
sis (Turner-Warwick, (988). The patient has a rapid high PacD2, a low Pao2, and a pH of less than 7.30 (Mc
rate of breathing and is using the accessory respiratory Fadden and Lyons, 1968).
muscle (Figure 4-6). The expiratory phase of breathing Medical management of acute asthma has three
is prolonged with audible wheezing and rhonchi. How (2) mobilization of
goals: ( l ) relief of bronchospasm,
ever, when severe obstruction is present, the chest be secretions, and (3) maintenance of alveolar ventila
comes silent (Gold, 1976). The patient may cough tion. Th e r e f ore m o s t hospitalized patients with
often, though unproductively, and may complain of asthma are treated with IV fluids, bronchodilators,
tightness in his chest. Radiologically, the lungs may ap supplemental oxygen, and corticosteroids.
pear hyperinflated or show small atelectatic areas from An asthma attack that persists for hours and is unre
retained secretions. The degree of tachypnea, hyperin sponsive to medical management is referred to as sta
flation, accessory muscle use, and pulsus paradoxus tus asthmaticus. The patient may appear dehydrated,
(difference in systolic blood pressure during inspiration cyanotic, and near exhaustion from labored breathing.
and expiration) are useful guides for determining the In contrast to the audible whcczing and rhonchi heard
degree of airway obstruction present (Woolcock, 1994). early in the attack, the chest now has greatly dimin
Early in the attack, arterial blood gases reflect slight hy ished or absent breath sounds. Status asthmaticus re
poxemia and a low Paco2 (from hyperventilation). If the sults in a significant death rate and is regarded as a
attack progresses, the PaD2 continues to fall as the PacD2 medical emergency. Bilateral manual lower chest com
climbs above the normal range. As obstruction becomes pression assists expiration and has value as an emer
severe, deterioration of the patient occurs, evident by a gency treatment of asthma (Fisher, Bowery, and Ladd
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4 Cardiopulmonary Pathophysiology 79
FIGURE 4-7
Gross specimen of lung showing large mucus plug within the bronchial tree of a patient who died
from status asthmaticus. (Courtesy of J. J. Coalson, Ph.D.)
Hudson, 1989; Watts, 1989). Patients in respiratory bronchial lumen, further contributing to the stasis of
failure may require mechanical ventilation. secretions. Although the alveoli are overinflated, the
Studies that examine the lungs of patients who die permanent destructive changes found in emphysema
from status asthmaticus find lungs that are signifi are not present.
cantly hyperinflated and do not deflate even when
Prognosis of asthma
the thorax is opened (Huber and Koessler, 1922;
Dunnill, 1960; Saetta et ai, 1991). Examination of Most studies following children with asthma for a
the airways reveals a mucosa that is edematous and number of years report a death rate of about 1 %
inflamed. Characteristic of asthma, the basement (Ogilvie, 1962). One large study of 1,000 people with
membrane is thickened. The mucous glands are en asthma of all ages in England reported a mortality of
larged, and there is an increase in the number of gob 7% as a result of asthma or its complications. This
let cells. Evidence of bronchospasm is seen by the study reported that 2% of the patients with intermit
hypertrophied and thickened smooth muscle. The lu tent asthma died, compared with 9% of those with
mens of most bronchioles, down to the terminal continuous asthma. During the 1960s, there was a
bronchioles, are filled with viscous, sticky mucus sharp increase in the number of deaths among people
(Figure 4-7). It is evident that the occluded bronchi with asthma reported by countries around the world.
oles have caused death by asphyxiation. Secretions At the peak of this increase, England and Wales re
in the tracheobronchial tree of the patient with ported that 7% of the deaths in children between 10
asthma are a combination of mucus, secreted by the and 14 years of age were attributable to asthma. This
mucous glands, and an exudate from the dilated cap reflected a 700% increase in only 7 years. Some med
illaries just below the basement membranae. It has ical authorities feel this increase in deaths was related
been shown that cilia do not sweep the mucoserous to widespread use or abuse of certain pressurized
t1uid nearly as effectively as pure mucus. In addition, aerosol nebulizers containing isoproterenol, but this
sheets of ciliated epithelium have been shed into the has been disputed (Gandevia, 1973). In 1987 there
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80 PART I Cardiopulmonary Function in Health and Disease
were more than 4,300 deaths from asthma in the Un bronchi to resemble varicose veins (Figure 4-8). Sac
tied States, 31% more than in 1980 (McFadden and cular (or cystic) bronchiectasis refers to airways that
Gilbert, 1992). have intermittent sphcrical ballooning (Figure 4-9).
Bronchiectasis is usually localized in a few seg
ments or in an entire lobe of the lung. Most com
Bronchiectasis
monly, it is unilateral (although 40% to 50% of the
Bronchiectasis is defined as an abnormal dilation of cases are bilateral) and affects the basal segments of
medium-size bronchi and bronchioles (about the the lower lobes. When the left lower lobe is involved,
fourth to ninth generations), generally associated with it is not unusual to find bronchiectasis in the lingula of
a previous, chronic necrotizing infection within these the left upper lobe as well. Interestingly, bronchiecta
passages. Ordinarily, there is sufficient cartilage sis of the right middle lobe is relatively common in
within the walls of the larger bronchi to protect them older adults and can contribute to both hemoptysis
from dilation. and repeated infections of this lobe. Upper lobe
The airway deformities can be classified into three bronchiectasis generally involves the apical and poste
types (Reid, 1950; Luce, 1994). Cylindrical (or longi rior scgments and is usually caused by tuberculosis or
tudinal) bronchiectasis is the most common type, bronchopulmonary aspergillosis.
with a uniform dilation of the airways. Varicose Pathologically, the mucosa appears edematous and
bronchiectasis refers to a greater dilation than in ulcerated. Destruction of the elastic and muscular
cylindrical bronchiectasis, causing the walls of the structures of the airway walls is evident with resultant
FIGURE 4-8
A, AP chest film of a bronchogram with cylindrical and varicose bronchiectasis in the lower lung
fields. B, Close-up view of cylindrical and varicose bronchiectatic changes in the left lower lobe.
(Courtesy of T. H. Johnson, M.D.)
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4 Cardiopulmonary Pathophysiology 81
dilation and fibrosis. The walls are lined with hyper Obstruction can cause bronchiectasis by collaps
plastic, nonciliated, mucus-secreting cells that have ing lung tissue (atelectasis) distal to the obstruction
replaced the nOImal ciliated epithelium. This change (Barker and Bardana, 1988). The increased negative
is significant, because it interrupts the mucociliary pressure in the chest (from the collapsed lung) exerts
blanket and causes pooling of infected secretions, a greater traction on the airways, causing them to ex
which further damage and irritate the bronchial wall pand and to become distorted. Secretions are re
(Barker and Bardana, 1988; Currie et ai, 1987). tained, and if the obstruction is prolonged, an infec
The etiology of bronchiectasis is related to ob tio.u occurs that begins to destroy the walls of the
struction of the airways and respiratory infections bronchi, as described above. There has been a signifi
(Luce, 1994; Simpson, 1975). Some 60% of the cases c a n t reduction in the n u m b e r of p a t i e n t s w i t h
of bronchiectasis are preceded by an acute respiratory bronchiectasis since the introduction o f antibiotics to
infection. The infection involves the bronchial walls. treat respiratory infections.
Portions of the mucosa are destroyed and are re Twenty-four-hour sputum volume has been used
placed by fibrous tissue. The radial traction of the as an indicator of severity of disease to categorize pa
lung parenchyma on the damaged bronchi causes the tients with bronchiectasis (Ellis et aI, 1981). Those
involved airways to become permanently dilated and producing less than 10 ml per day have been catego
distorted (Barker and Bm·dana, 1988). These areas, rized as having mild bronchiectasis, to to I SO ml as
devoid of normal ciliated cells, contain secretions moderate bronchiectasis and greater than I SO ml as
that eventually become chronically infected. having severe bronchiectasis.
FIGURE 4-9
A, AP chest film of a bronchogram shows saccular bronchiectasis. B, Close-up view of
bronchiectatic areas with grapelike saccular bronchiectasis. (Courtesy of T. H. Johnson, M.D.)
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82 PART I Cardiopulmonary Function in Health and Disease
P atients w ith severe, diffuse, long-standing accumulated overnight. Therapists teaching the pa
bronchiectasis are rare today. Physically, they are ema tient postural drainage positions devised to drain the
ciated, and as many as 25% of them may have clubbed involved segments should keep in mind that this dis
fingers. A chronic cough, with expectoration of un ease causes distortion and dilation of the bronchi;
pleasant-tasting, purulent sputum is typical in these pa hence the traditional positions found in books may be
tients. When this sputum is collected and allowed to of limited value in determining the precise segment of
stand, it may separate into three distinct layers: the up the lung that is the source of the secretions. If the in
permost layer is frothy, the middle layer is serous or volvement is in the lower lobes, the patient should be
mucopurulent, and the lowest layer is purulent and placed in the Trendelenburg position and should be
may contain small grayish or yellowish plugs (Dit gradually rotated from lying on one side, to supine, to
trich's plugs). Changes of body position, while sleep lying on the opposite side, and prone, if tolerated,
ing or on arising, often stimulate coughing as the while doing the FET and/or receiving percussion and
pooled secretions again spill onto the mucosa of nor vibration 5 to to minutes per segment over all sur
mal, larger airways. These individuals may have cor faces of the lower lobe being treated. A similar proce
pulmonale from fibrosis that has extended to involve dure may be followed while sitting if the upper lobes
the pulmonary capillary bed. Patients with widespread require drainage, but these segments rarely require
bronchiectasis appear dyspneic and have increased drainage, since they usually drain during the course of
work of breathing as a result of hypoxemia and hyper the day while the individual is in a more or less erect
capnia from ventilation-perfusion mismatching. Anas position. Positions that are especially productive
tomosis of the bronchial and pulmonary vascular sys should be emphasized and drained longer. The patient
tems causes shunting of the systemic blood from the should be instructed to do the postural drainage even
hypertrophied bronchial arteries. It also may contribute if the treatment seems unproductive. Secretions may
to a decreased capability to take oxygen into the in be mobilized during treatment and it can take several
volved segments of the lung (Liebow, Hales, and Lind minutes for the remaining cilia to sweep the mucus far
skog, 1949; Luce, 1994). enough up the tracheobronchial tree to be expecto
Most patients complain of relatively few symp rated or swallowed.
toms, except during a respiratory infection when they Pulmonary function tests of patients with localized
have an increased cough and sputum production. The bronchiectasis show few or no abnormalities. How
amount of sputum expectorated and the severity of ever, in more widespread disease, there is a reduction
the cough vary from patient to patient, according to in the FEV I, maximum midexpiratory flow rate, max
the amount of involvement. Hemoptysis does occur imal voluntary ventilation (MVV), diffusing capacity,
in about half of the older patients, evidently because and an increase in the residual volume (Luce, 1994).
of erosion of enlarged bronchial arteries that accom Hospitalized patients with bronchiectasis may be
pany the dilated bronchi. treated with postural drainage, percussion, vibration,
Effective postural drainage, percussion, vibration, and/or the forced expiratory technique, intravenous
and the forced expiratory technique (FET) are impor fluids, antibiotics, supplemental oxygen and other
tant in the management of bronchiectasis (Gallon, medications (Stoller and Wiedemann, 1990; Luce,
1991; van Hengstum et aI, 1988; Sutton, 1983; Ver 1994). Long-term medical management may include
boom, Bakker, and Sterk, 1986) (see Chapter 20). ,It a broad-spectrum antibiotic taken orally 10 to 14
should be done as frequently as indicated in patients days per month, low-flow oxygen for hypoxemia,
with a productive cough. Postural drainage should be postural drainage, avoidance of bronchial irritants
done I hour before retiring at night to facilitate the ex (e.g., cigarette smoke and air pollution) and other
pectoration of secretions that would interfere with rest measurers. Some patients may have surgical resection
by stimulating violent coughing when the patient if their area of involvement is quite limited or to con
changes positions. It should also be done on arising in trol hemoptysis. It is most important that these pa
the morning to clear the lungs of secretions that have tients drink large volumes of water each day (2 to
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4 Cardiopulmonary Pathophysiology 83
3 L) to keep their secretions thin so they can be ex spondylitis can cause lung restriction. Obesity and as
pectorated more easily (unless fluid intake is limited cites, by limiting diaphragmatic movement, can also
for cardiac reasons). produce a restrictive defect.
Pulmonary function tests generally show a de
Prognosis of bronchiectasis
creased vital capacity, inspiratory capacity, and total
Before the antibiotic era, the prognosis for individuals lung capacity, whereas the residual volume can be
with bronchiectasis was poor. As might be expected, normal or reduced. If the restriction is pulmonary in
infection was usually the precipitating cause of death. origin, there is a reduction in the lung compliance
However, at the present time, the prognosis of patients and the diffusing capacity.
with proper medical management is much improved Many of these restrictive disorders are discussed
(Sanderson et aI, 1974; Ellis et ai, 1981). Most studies in Chapter 5. Since obstructive lung diseases are en
show that about 75% of the patients have an improved countered much more often than restrictive disorders,
symptom complex since diagnosis and lead relatively they have been discussed in greater detail. The fol
normal lives. Cor pulmonale, a complication of dif lowing is a brief examination of some of the restric
fuse, long-standing bronchiectasis, accounts for about tive lung diseases.
50% of the deaths (Konietzki, Carton, and Leroy,
1969). Pneumonia and hemorrhage are less common
Diffuse Interstitial Pulmonary Fibrosis
causes of death. With modern therapy, only a few pa
tients succumb to respiratory infections or their com This disease is known as diffuse interstitial pul
plications. Few children who develop bronchiectasis monary fibrosis (IPF) in the United States and cryp
live beyond their 40s. Repeated bronchopulmonary in togenic fibrosing alveolitis in Europe (Reynolds, and
fections can contribute to worsening pulmonary func Matthay, 1990). IPF represents a common histologic
tion and an earlier death. Before the antimicrobial era, response to a wide variety of insults (Weg, 1982).
most patients with untreated, widespread, severe Initially, some type of injury to the pulmonary
bronchiectasis died within 25 years. Today prognosis parenchyma causes an influx of inflammatory and
for each individual depends on the extent of the dis immune cells, resulting in a diffuse inflammatory
ease process at the time of diagnosis and on proper process distal to the terminal bronchiole (alveolitis).
medical management. Patients with moderate, local This can progress to subacute interstitial disease with
ized disease, if treated properly, may have a relatively the presence of acute and chronic inflammatory ceUs.
normal life expectancy. Chronic disease is manifest by thickened alveolar
walls and progression to fibrosis.
The etiologic factors of this condition are uncer
RESTRICTIVE lUNG DISEASE
tain. Similar conditions can be produced by certain
A restrictive disease is characterized by lungs that are drugs or poisons and are found in patients with
prevented from expanding fully. Normally during in rheumatoid arthritis and systemic sclerosis. There
spiration, the diaphragm descends, the dimension of appears to be a genetic factor, since twins, siblings,
the chest increases laterally and anteriorly, and the and other members of the same family have been re
lung tissue expands as it fills with air. Hence an ab ported with diffuse interstitial pulmonary fibrosis.
normality in any of these areas can produce a restric This condition has also been reported in a few indi
tive pattern. For example, a decrease in compliance viduals with Raynaud's phenomenon, ulcerative col
or elasticity of the lung parenchyma, such as intersti itis, and other diseases, but their exact relationship
tial fibrosis, sarcoidosis, pneumoconiosis, and sclero remains unclear.
derma, can produce this defect. Pleural abnormalities The most common early symptoms are fatigue,
such as pleural effusion (by direct compression) can dyspnea on exertion, and a chronic unproductive
prevent the lungs from expanding fully. Thoracic cough. As the disease progresses, the patient becomes
changes such as kyphoscoliosis and ankylosing steadily more dyspneic and cyanotic. On auscultation,
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84 PART I Cardiopulmonary Function in Health and Disease
one notes sharply crackling rales. Chest expansion is Since a pattern of DIP is commonly seen along with
reduced and clubbing of the digits is often present. usual interstitial fibrosis (UIP) or IPF, some believe
The chest x-ray usually indicates diffuse reticu that DIP likely represents an earlier and more re
lar markings, most prominent in the lower lung versible stage of IPF.
fields. Sometimes, a gallium citrate Ga 67 isotope Cortiocosteroids are the mainstay of treatment for
scan of the lungs is conducted to assess the overall IPF (Reynolds and Matthay, 1990). A trial of im
inflammation of the lung parenchyma (Line et ai, munosuppressive therapy is almost a l ways pre
1978; Turner-Warwick and Haslam, 1987). scribed for a period of time. Obj ective measures
Pulmonary function tests show a reduced vital ca such as blood counts, erythrocyte sedimentation rate,
pacity and total lung capacity with no impaired flow pulmonary function testing, particularly exercise
rates (Keogh and Crys tal, 1980; Reynolds and tests with measurement of arterial oxygen desatura
Matthay, 1990). Compliance is markedly reduced to tion and diffusing capacity BAL fluid analysis and
less than half of the predicted value. A reduced diffus the patient's symptoms must demonstrate improve
ing capacity is the earliest and most consistent change. ment or the medication should be discontinued. A
At first, the arterial Pa02 may be normal at rest but composite clinical roentgenographic, physiological
may drop significantly with exercise. The Paco2 is re score (CRP score) of eight variables has been devel
duced as a result of hyperventilation, and the pH is oped that allows quantification of the clinical course
kept normal by renal compensation. Later the Pao2 is and the re sponse to therapy in individual patients
markedly reduced because of the thickened alveolar (Watters et ai, 1986). If effective, medications are
membrane and ventilation-perfusion mismatching. usually continued for a year and then a decision is
Bronchoalveolar lavage (BAL) is often used to as made about continuing or tapering the dosage.
sess the amount of inflanunation and the accumulation Individuals who are not responsive to corticos
of immune effector cells and proteins in the alveoli teroids may be placed on other immunosuppressive
(Crystal, et ai, 1981; Rudd, Halslam, and Turner-War drugs such as cyclophosphamide, azathioprine, or
wick, 198]). The technique consists of wedging a penicillamine (Turner-Warwick, 1987; Reynolds and
fiberoptic bronchoscope in a sublobar airway, then in Matthay, 1990). Penicillamine is more effective in
fusing 20 to 50 ml aliquots of saline into the periph patients with connective tissue diseases and intersti
eral airway, which are immediately aspirated by sy tial fibrosis other than those with IPF.
ringe. A total of 150 to 300 ml is ins tilled and Patients should stop smoking at once. Supplemen
recovered. The fluid and cells are analyzed (Reynolds, tal oxygen is important with exercise as there is a
1987). High-intensity alveolitis is defined by 10% or characteristic significant fall in arterial oxygen ten
more polymorphonuclear granulocytes (PMNs) in sion ( Pa02) (Hammon a n d Mc C a f f ree, 1985;
BAL cell differential counts; low-intensity alveolitis Reynolds and Matthay, 1990). Individuals that re
consists of 10% PMNs or less (Reynolds, 1986). quire more than 4 L flow/min by nasal prongs may
Lung biopsies that demonstrate an abundance of prefer direct administration of oxygen into the tra
inflammatory cells suggest early disease, whereas a chea. In addition to supplying higher concentrations
prevalence of fibrosis is indicative of advanced dis of oxygen to the lungs, many patients prefer the cos
ease. A distinct category of IPF has been described metic effective of not wearing obvious nasal prongs.
and may be clinically useful (Liebow, Steer, and Patients that have refractory disease limited to the
Billingsley, 1965). Desquamative interstitial pneu lungs may be candidates for single or double lung trans
monitis (DIP) is characterized by an intraalveolar ac plantation. There have been significant advances in the
cumulation of mononuclear cells, relatively intact success of lung transplantation in recent years (Toronto
alveolar walls without destruction or fibrinous exu Lung Transplant Group, 1988) (see Chapter 38).
dates (numerous inflammatory cells with little or no Individuals with the subacute form described by
fibrosis). This pattern has correlated with a more be Hamman and Rich usually die within 6 months
nign course and a better response to corticosteroids. (Hamman, 1944). Patients with the chronic form,
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4 Cardiopulmonary Pathophysiolog)' 85
treated with steroids, may survive for as long as 15 complex. Over time, it can eventually result in a form
years. Untreated, these patients most often die within of interstitial pu lmonary fibrosis with honeycombed
I to 4 years. Cause of death is usually related to res lung changes on chest x-ray and a restrictive pattern
piratory or heart failure, although an unexpected on pulmonary function tests.
number have died from adenocarcinoma and undif This disease is more common in women (Seder
ferentiated or alveolar cell carcinoma of the lung. linic, Sicilian, and Gaensler, 1988). Their symptoms
include an acute respiratory illness with fever, night
sweats, weight loss, and dyspnea. It can be confused
Pulmonary Infiltrates With Eosinophilia
with tuberculosis, but these patients deteriorate when
Eosinophils are commonly present in lung tissue as treated with antituberculosis drugs. This disease must
part of the body's cellular response to a variety of also be differentiated from eosinophilic granuloma
agents and systemic immunologic diseases (Butter and the desquamative form of idiopathic interstitial
worth and David, 1981). They are present in the air pneumonitis. Dense infiltrates located in the periph
ways and lung tissue of patients with idiopathic pul ery of the lung on chest x-ray provide an important
monary fibrosis. In interstitial lung disease that clue. Often, a lung biopsy is necessary to confirm the
appears to have an allergic component (e.g., hypersen diagnosis. Treatment with cortiocosteroids produces
sitivity pneumonitis, drug-induced lung syndromes, a striking improvement in the patient's symptoms and
sarcoidosis) eosinophils are a minor component of tis chest x-ray in just a few weeks.
sue reaction. However, in certain primary or systemic
diseases, eosinophils can be the most conspicuous in
Eosinophilic granuloma
flammatory cell present in the lung. These conditions Eosinophilic granuloma (or histiocytosis X) can ei
can be grouped t o g ether and referred to a s ther be a unifocal disease effecting only the lungs or
eosinophilic syndromes (Crofton e t aI, 1952). Consid a multifocal disease involving the bones of the skull,
erable overlapping exists among these syndromes as mandible, vertebra, pelvis, ribs, and extremities
their etiologic factors and pathogenesis remains (Groopman and Golde, J 981; Marcy and Reynolds,
poorly understood (Reynolds and Matthay, 1990). 1985). Lung involvement is characterized by an inter
stitial granuloma composed of moderately large, pale
Simple pulmonary eosinophilia histiocytes and eosinophils, and arteriolitis with
This is a self-limiting disease with chest x-ray eosinophils. The histiocytic process with eosinophils
demonstrating migratory, fleeting areas of pulmonary then involves bronchioles, alveolar ducts, and alveo
infiltrates located in the periphery of the lungs along lar septa, which results in their destruction. The pro
with minimal respiratory symptoms and blood liferative endarteritis causes necrosis.
eosinophilia (Crofton et aI, 1952). Certain drugs such This disease most commonly effects men in their
as sulfonamides have been implicated as a cause 30s or 40s. They usually have symptoms of fatigue,
(Reynolds and Matthay, 1990). This disease is also malaise, weight loss, a nonproductive cough, dyspnea
referred to as Loeffler's pneumonia and the PIE syr on exertion, and chest pain, sometimes related to a
drome (peripheral infiltrates with blood eosinophilia) pneumothorax or rib lesions. The chest radiograph
(Crofton et aI, 1952). If the Jisease is related to an al often indicates a diffuse micronodular and interstitial
lergic rcsponse LO microfilaria, human parasites (e.g., infiltrate initially involving the middle and lower
Ascaris lum.briocoides, Strongyloides stercoralis), or lung fields. In more advanced disease, small cystic
cat and dog parasites (ascarids) that produce visceral areas develop in the infiltrate, producing a honey
larva migrans, it is termed tropical eosinophilia. comb pattern. Spontaneous pneumothorax is a com
plication in approximately 25% of cases.
Prolonged pulmonary eosinophilia The course of the disease varies (Reynolds and
As implied by the name, this disease is more chronic Matthay, 1990). Spontaneous regression with residual
than the simple form, with a more severe symptom symptoms may occur in 10% to 25% of cases. In
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86 PART I Cardiopulmonary Function in Health and Disease
many patients, the disease stabilizes or "burns out," findings may include fine inspiratory rales, dullness to
leaving them with a moderate pulmonary impairment percussion and, in the later stages, cyanosis and club
as a result of fibrosis, cystic lung changes and a re bing. Pulmonary function studies usually show a de
strictive defect on pulmonary function tests. Dyspnea creased vital capacity, functional residual capacity arid
on exertion is common. Some patients have persistent diffusing capacity. Arterial blood gases indicate a low
bronchitis. Cortiocosteroids are not particularly effec Pao2, especially during exercise, with normal Paco2,
tive. Treatment is mainly symptomatic, with judicious and pH (Rogers et aI, 1978).
use of antibiotics and bronchodilators. Occasionally, The treatment of choice for patients with moderate
progressive pulmonary disease leads to cor pulmonale to severe dyspnea on exertion from alveolar pro
and respiratory failure. teinosis is bronchial alveolar lavage (Rogers and
Tatum, 1970; Rogers, Graunstein, and Shuman
1972). The patient is taken to the operating room
Pulmonary Alveolar Proteinosis
where, after general anesthesia and placement of a
Pulmonary alveolar proteinosis is a rare disease of double-lumen tube (which isolates each lung), the pa
unknown origin, characterized by alveoli filled with tient is turned in the lateral decubitus position with
lipid-rich "proteinaceous" material and no abnormal the lung to be lavaged downward. The double-lumen
ity of the alveolar wall, interstitial spaces, conducting tube enables the patient to be ventilated by the upper
airways or pleural surfaces. Most often it is found in most lung while the lower lung is carefully filled with
men between the ages of 30 and SO, although it has saline to the functional residual capacity. Then an ad
been reported in patients of all ages and both sexes. ditional 300 to 500 ml saline are alternately allowed
The most common symptoms are progressive dysp
nea and weight loss, with cough, hemoptysis and chest
pain reported less frequently (Claypool, Rogers, and
Matuschak, 1984). Chest x-ray reveals diffuse bilateral
(commonly perihilar) opacities (Figure 4-10). Physical
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4 Cardiopulmonary Pathophysiology 87
to mn into and out of the ung by gravitational flow. and Matthay, 1990). If the patient is assessed during
As the saline flows out, percussion is done over the an acute episode of pulmonary hemorrhage, fine rales
lung being lavaged, and this grcatly increases the and dullness to percussion are present on physical ex-
amount of proteinaceous material washed from the amination. An enlarged liver, spleen, and lymph
lung (Figure 4-1 J). The effectiveness of mechanical nodes may be noted on palpation in 20% to 25% of
percussion, manual vibration, and manual percussion cases. The chest x-ray during acute episodes show
in removing the material from involved lungs has 'Dac naI consolidation for 2 to 3 days, then a reticular
been compared and manual percussion has been pattern identical to other interstitial diseases. The
found to be superior (Hammon, 1983; Hammon ,/' chest x-ray usually returns to normal in lO to 12 days.
'-i
Freeman, and McCaffree, 1986; Hammon, McCaf- However, after recurrent episodes with hemosiderin
free, and Cucchiara, 1993). In this procedure, a pa- deposited in the interstitial spaces, there is progres
tient is usually lavaged with 20 to 30 L saline and is sive interstitial fibrosis .. Pulmonary function tests in-
then taken to the recovery room and later back to his dicate a decreased diffusing capacity, with or without
or her own room. After 2 or 3 days, the procedure is a fall in the patient's resting Pa02.
repeated on the opposite lung. The hemorrhage is ordinarily confined to the pe-
Most patients have significant clinical improve ripheral airspaces. Interestingly, massive blood loss
ment following bronchial alveolar lavage, and many into lung tissue can occur without hemoptysis or no-
have an improvement in their chest x-rays (Claypool, ticeable blood in the trachea or major bronchi
Rogers, and Matuschak, 1984). After lavage, for rea (Reynolds and Matthay, 1990). Sputum samples of
sons that are unclear, the material may reaccumulate BAL f l uid may c o n t ain hemosi d e r i n-l a d e n
slowly o r not at all. Some patients d o have sponta macrophages. After recurrent episodes of hemoptysis,
neous remissions without undergoing lavage. interstitial fibrosis is present in most cases.
Before bronchial alveolar lavage was done on The prognosis of IPH is variable with death occur-
these patients, almost all children with alveolar pro- ring somewhere between 2Y2 to 20 years after the
teinosis died, and 20% to 25% of the adults died onset of symptoms. Permanent remissions may occur
within 5 years, usually because of respiratory failure with or without corticosteroid administration. No
or cor pulmonale. Some 60% to 70% improved treatment has been shown to effectively alter the out-
greatly or recovered. The effect that bronchial alveo come of this disease.
lar lavage has on the long-term outcome remains to
be seen, but present results are encouraging (Clay
Sarcoidosis
pool, Rogers, and Matuschak, 1984).
Sarcoidosis is a granulomatous disorder of unknown
origin that can effect multiple body systems (Mitchell
IdiopathiC Pulmonary Hemosiderosis
and Scadding, 1974). Typically, initial findings can
Idiopathic pulmonary hemosiderosis (IPH) is a dis include bilateral hilar adenopathy, pulmonary infiltra
ease of unknown origin and is characterized by re tion and skin or eye lesions (Sharma, 1977). The
peated episodes of pulmonary hemorrhage, iron-defi lungs are the organs most often involved and some
ciency anemia, and in long-term patients, pulmonary 20% to 50% of these patients first seek medical atten
insufficiency (Soergel and Sommers, 1962). IPH is tion because of respiratory symptoms. It affects
most commonly found in children under the age of blacks 10 to 20 times more often than whites and
10. In children, it is found with equal frequency in women twice as often as men. It usually occurs in the
both genders, but in adults, it is twice as common in third or fourth decade of life.
men as it is women. The intrathoracic changes can be classified into
This disease has an insidious onset. The patient four stages (Siltzbach et aI, 1974; Weg, 1982). In the
has symptoms of weakness, anemia, pallor, lethargy, first stage, the patient is asymptomatic, with the chest
and occasionally, a nonproductive cough (Reynolds x-ray showing bilateral hilar adenopathy and right
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88 PART I Cardiopulmonary Function in Health and Disease
FIGURE 4-12
A, Sarcoidosis in its first stage is manifested by bilateral hilar adenopathy. Usually there are no
significant physical symptoms. B, Disseminated sarcoidosis (third stage) reveals widespread
parenchymal changes with scarring. The hilar adenopathy is usually decreased. (Courtesy of
T. H. Johnson, M.D.)
paratracheal adenopathy (Figure 4- J 2, A). In the second the lungs and pleurae. The most common thoracic
stage a diffuse pulmonary infiltration is found along complication of RA is pleurisy, with or without
with the bilateral hilar adenopathy. Interstitial infiltra pleural effusions. Although RA occurs twice as often
tion or fibrosis, without hilar adenopathy, characterizes in women, pleuritis has a striking predilection for men
the third stage (Figure 4-12, B). In the fourth stage, em (Reynolds and Matthay, 1990). Pleural disease is one
physematous changes, cysts, and bullae are found. manifestation of RA, occasionaJJy causing fibrothorax
I n 60% to 90% of t h e s e p a t i e n t s w i t h h i l a r and restrictive lung disease that requires decortication.
adenopathy, the disease spontaneously regresses over Interstitial lung disease, indicated by abnormal pul
a period of I to 2 years. About one third of the pa monary function tests demonstrating a restrictive venti
tients with sarcoidosis involving the lungs also have a latory impairment and a reduced ventilatory capacity, is
spontaneous regression, usually leaving some resid evident in about 40% of RA patients (Frank et ai,
ual fibrosis. The remaining two thirds that have 1973). It is also more prevalent in men. The chest x-ray
chronic sarcoidosis have progressive pulmonary im demonstrates diffuse interstitial infiltrates, especially in
pairment, along with a variable degree of involve the lung bases. Pulmonary nodules, which are patho
ment of the heart, liver, spleen, lymph nodes, mus logically identical to the subcutaneous nodules found in
cles, bones, and central nervous system (CNS). RA, may also oceur and cavitate (Weg, 1982).
Most patients with sarcoidosis need no treatment. C o al miners with RA may have chest x - rays
Corticosteroids, although controversial, are the most demonstrating rounded densities that evolve rapidly
effective forms of therapy for patients with sarcoido and undergo cavitation (Caplan's syndrome) in con
sis that requires treatment (DeRemee, 1977; Turner trast to the massive fibrosis found in coal miners'
Warwick et ai, 1986). pneumoconiosis (Caplan, 1953).
Rheumatoid arthritis (RA) is a systemic disease that Although systemic lupus erythematosus (SLE) is a
principally involves the joints but also often affects systemic collagen vascular disease, some 50% to
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4 Cardiopulmonary Pathophysiology 89
90% of these patients have pleural or pulmonary in group, progression results in death after several years.
volvement (Hunninghake and Fauci, 1979). Pleuritic Women seem to have a poorer prognosis than men.
chest pain often signals polyserositis associated with
SLE. Pleural effusions are a manifestation of poly CORONARY ARTERY DISEASE
serositis and are present in 40% to 60% of individuals
with SLE. Most often they are bilateral. Atherosclerosis
Patients with pulmonary involvement present with
dyspnea on exertion and cough productive of mucoid Pathophysiology
sputum (Weg, 1982). Rarely do SLE patients com To discuss CAD the process of atherosclerosis must
plain of supine dyspnea, which suggests diaphrag first be described. Although the specific pathogenesis
matic paralysis or a diffuse myopathy of the di of atherosclerosis is not known, it is hypothesized
aphragm (Gibson, Edmonds, and Hughes, 1977). that the process is initiated by trauma to the intima of
The chest x-ray usually indicates patchy, nonspe the arterial wall. The trauma may be related to vari
cific densities and/or basilar linear or platelike atelec ous primary risk factors such as: high blood pressure
tasis. Pleural effusions and pulmonary infiltrates are and cigarette smoking.
common, whereas diffuse interstitial fibrosis is rarely High blood pressure has been indicated as a poten
seen (Hunninghake and Fauci, 1979). tial trauma inducer, since increased pressure and turbu
Pulmonary function tests often indicate a restric lence may damage the endothelial cells of the intima,
tive pattem with a decreased diffusing capacity and a thus exposing the media to the circulation. The media,
reduced arterial oxygen saturation. which is composed primarily of smooth muscle is
thought to be the origin of the atherosclerotic lesion.
Cigarette smoking has also been indicated as a po
Progressive SystemiC Sclerosis (Scleroderma)
tential trauma inducer. However, the hypothesized
Progressive systemic sclerosis (scleroderma) is a rare mode of injury is different than that observed with in
disease that causes thickening and fibrosis of the con creased blood pressure. Cigarette smoke is high in
nective tissue of mUltiple parts of the body with re carbon monoxide and hydrocarbons that are carried
placement of many elements of the connective tissue by the red blood cells and the plasma. It is thought
by colloidal collagen. The skin is most often in that the hydrocarbons or carbon monoxide bind to the
volved, although the lungs, heart, kidney, bones, and endothelial cells, causing damage and possibly death
other parts of the body can also be affected. to these cells.
Approximately one half to two thirds of the pa Once the media is sufficiently exposed to the circu
tients with progressive systemic sclerosis have pul lation the process of atherosclerosis is initiated.
monary involvement (Reynolds and Matthay, 1990). Platelets aggregate at the injury site and release sub
Many of these patients with pulmonary involve stances that induce endothelial and smooth muscle
ment are asymptomatic, although symptoms can in cell replication. It is at this site that fatty streaks and
clude weight loss, progressive dyspnea, low-grade fibrous plaques are developed. The cause of fatty
fever, and cough (sometimes producing mucoid spu streak development is that low-density lipoproteins
tum). Chest x-ray shows a characteristic fibrosis of the (LDLs) deposit fat into the smooth muscle of the
mid and lower lung fields. Auscultation often reveals media. Why this occurs is unknown, but apparently is
bibasilar rales. Pulmonary function tests reveal a re related to the smooth muscle cell proliferation and
strictive defect with impaired diffusion. perhaps increased need for energy. The initial fatty
D-penicil lamine is the best treatment for pul streaks are generally only slightly raised and do not
monary involvement in patients with progressive sys imperil circulation. However, when a fibrous plaque
temic sclerosis (DeClerk et ai, 1987). develops, the characteristic impingement of the vessel
Prognosis of patients with only skin and joint in lumen occurs. The plaque is somewhat hard and con
volvement is much better than for those that have in sists of connective "scar-like" tissue, smooth muscle
volvement of the heart, lungs and kidneys. In the latter and fat. Finally, the plaque may undergo calcification
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90 PART I Cardiopulmonary Function in Health and Disease
or lead to hemorrhaging if the vessel wall necroses. angina, the episodes are more frequent and the dura
The result is decreased blood flow (ischemia) and tion of each event is usually greater than 15 min
oxygenation (hypoxia), or complete lack of blood utes. In addition the intensity or the pain may be
flow and oxygen (anoxia) to the target organ. more severe. Unstable angina is usually an indicator
of CAD progression. Individuals with unstable
Risk factors angina are at greater risk to have a myocardial in
As described above high blood pressure, cigarette farction (MI). Unstable angina is less responsive to
smoking and hyperlipidemia are direct or primary treatment using rest and sublingual nitrates. Often
risk factors for causing atherosclerosis. Secondary times, the individual must be hospitalized and
risk factors are age, gender, race, obesity, stress, and treated with IV nitrates.
activity level. Several risk factors are modifiable and
i n c l u d e: (I) h y pertension, (2) h y pe r l i p idemia, Variant angina
(3) smoking, (4) obesity, (5) stress level, and activity Variant angina occurs while the individual is at rest,
level. It is interesting to note that the "big three" pri usually during waking and often at the same time pe
mary risk factors are all modifiable by the individual. riod. Exertion does not influence variant angina.
Reducing risk factors can reduce the probability of However, the angina may benefit from rest and sub
CAD by five- to ten-fold (Ornish et aI, 1990). lingual nitrates. Like unstable angina the pain is in
tense and of longer duration and likely to lead to an
MI. In addition, arrhythmias are more likely to occur
CLINICAL SYNDROMES ASSOCIATED WITH CAD with an individual who has variant angina, as com
pared with exertion related angina (i.e., stable and un
Angina Pectoris
stable). Stable and unstable angina are believed to be
Angina pectoris is defined as chest pain that is related caused primari Iy by progressive arterial occlusion
to ischemia of the myocardium. However, the pain and ischemia. It is believed that variant angina is
referred from ischemia may be in the left shoulder, caused by a combination of occlusion and coronary
jaw, or between the shoulder blades. Angina can be artery spasm. Therefore variant angina has been suc
classified as stable, unstable, or variant. cessfully treated with calcium channel blockers.
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4 Cardiopulmonat'y Pathophysiology 91
CAD is reversible when lifestyle adjustments are ini crease in cardiac performance at rest and during mini
tiated (Ornish et ai, 1990; Schuler et ai, 1992). mal to moderate activity (Cahalin, 1994). However
the location and the extent of the MI is also critical.
MIs located in the inferior portion of the heart are the
Myocardial Infarction
least significant, and partial wall thickness is less sig
MI is defined as necrosis of a portion of the my nificant than a transmural MY.
ocardium. The death of the myocardium occurs as a Treatment, The treatment for an uncomplicated MI is
result of ischemia and anoxia. The vessels affected initially like the complicated MI, where the patient is
are the right and left coronary arteries. The right cared for in the coronary care unit. The medical treat
coronary artery supplies portions of the inferior sec ment is designed to decrease myocardial work and
tion of the left ventricle and the posterior section. oxygen demand. Therefore patients are on oxygen
The left coronary artery branches and forms the cir and administered vasodilators (nitroglycerin) to in
cumflex and anterior descending arteries. The cir crease myocardial blood flow and analgesics to help
cumflex supplies the lateral portion of the left ventri further reduce ischemic pain. In addition, to reduce
cle, while the anterior descending artery supplies the contractility of the myocardium, calcium channel
anterior portion. In addition, the right coronary blockers or beta-blockers are administered. Finally,
artery supplies the right atrium atrial-ventricular antiarrhythmia medication may be prescribed if an
(AV) bundle and the right ventricle. The left coro aberrant cardiac rhythm is present or is highly proba
nary artery supplies the left atrium and the primary ble to occur.
portion of the conduction pathway. Generally, the Since the course is uncomplicated, this means
clinical symptoms are similar to that of angina, with that a patient's stay in the coronary care unit may be
emphasis on extreme pressure as well as tightness only 2 to 3 days, with a total hospital stay of 7 to 10
over the sternum region. In addition, pain can radiate days. Treatment following leU discharge is oriented
to the jaw, upper back, and shoulders (with left more toward increasing physical activity and in educating
frequent than right). the patient and family in risk factor reduction.
MIs can be classified into categories by size, loca This process is described as cardiac rehabilitation
tion, and degree of myocardial wall involvement. The Phase 1.
terms small and large are often used to describe MIs.
However, degrees of complication are also used in Complicated myocardial infarction
conjunction with size. MIs can be described as un A complicated MI is different from an uncomplicated
complicated and complicated based on size of the MI case since the patient may have one, a combination,
and recovery of the patient. Location indicates the or all four of the following conditions/complications:
portion of the heart involved and also what coronary (I) arrhythmia, (2) heart failure, (3) thrombosis, and
artery or branch that is at fault. As described above, (4) damage to heart structures.
the general regions of the heart are anterior, posterior, Arrhythmias. Arrhythmias occur in 95% of all pa
lateral, and inferior. Finally, MIs are classified by the tients with MIs. The type and severity of the arrhyth
extent of the wall damage. A transmural infarct (or mia is dependent on the extent of myocardial damage
full wall) extends from the endocardi um to the epi and the location of the damage. As described earlier,
cardium. There is the potential that only a small por the uncomplicated MI patient usually has a small area
tion of the ventricle wall is affected, such as just of the myocardium involved; thus the potential ar
below the epicardium (subepicardial) and just below rhythmias are less dangerous and occurrence is less
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92 PART I Cardiopulmonary Function in Health and Disease
poor stroke volume and ejection fraction, and again considered a distinct possibility in all surgical, MI,
impaired cardiac output. Treatment of the above con and gunshot patients.
ditions is immediate and requires drugs and poten Heart wall or mural wall thromhosis can lead to an
tially, electrical shock (for flutter/fibrillation). Usu emboli lodging in the brain, intestine, kidney, artery
ally, an artificial pacemaker is implanted once the to the extremities, or any location in the systemic ar
patient is stabilized. terial circulation. Usually mural thrombosis do not
Heart failure. Another complication following MI is affect the pulmonary system, since even the smallest
heart failure. Heart failure is a condition where the fragments are caught in capillary beds and do not
heart is weakened and is unable to produce a signifi enter into the venous system.
cant cardiac output to meet the bodies need for oxy Structural damage. The last complication is structural
gen, nutrition, and removal of waste products. When damage to critical myocardial tissue that affects heart
the heart experiences ischemia the myocardium con function. If conductant pathway (bundle branch) tis
tracts with less force, and conduction abnormalities sue located primarily at the septum is damaged, ar
may alter the mechanics of the contraction. If an area rhythmias result. In addition, papillary muscles that
of the heart is infarcted, the affected myocardium assist in closing valves can be infarcted. The result of
does not contract, thus affecting overall cardiac out improper valve function is decreased cardiac output.
put. Another type of heart failure not directly related Besides these two critical tissues, if significant full
to ischemia and infarction is congestive heart failure thickness damage occurs to the myocardial wall car
(CHF) (see Congestive Heart Failure, p. 000). diac function is compromised. HeaIt waJJ damage can
Immediately post-MI, cardiac output is reduced result in venlricular aneurysms or ventricular wall
significantly. However, the compensatory response is rupture. Ventricular aneurysm or bulging of the weak
to increase sympathetic innervation, resulting in in ened ventricular wall oecurs in transmural (full wall
creased heart rate and myocardial contractility. The thickness) infarcts. Ventricular wal I rupture, which
result of this compensation is a cardiac output that can occur acutely following transmural infarction, but
may approach normal resting values. However, if the more often occurs in the first to second week post-MI
damage has been great, the kidneys compensate by following an aneurysm is usually fatal. Therefore fol
retaining sodium and water in an attempt to improve lowing a n MI, it is critical to determine i f an
circulatory volume and venous return. Depending on aneurysm has occurred in the myocardium so that ap
the amount of myocardial tissue death, the individual propriate surgical intervention can be performed.
may survive with resulting chronic congestive heart Treatment. The treatment for a complicated MI is
failure through persistent fluid retention and hypoten initiaJly like the uncomplicated MI, where the patient
sion. If grcater than 40% of the left ventricle is in is cared for in the coronary care unit. The medical
farcted, the result is usually cardiogenic shock fol treatment once again is designed to decrease myocar
lowed by death of the individual. dial work and oxygen demand. Patients are on oxy
Thrombosis. Another complication is increased inci gen and administered vasodilators (nitroglycerin) to
dence of thrombosis from deep leg veins and from increase myocardial blood flow and analgesics to
the damaged heart itself. Thrombosis from deep leg help further reduce ischemic pain. Myocardium cal
veins occurs from lower limb inactivity and circula cium channel blockers or beta-blockers are adminis
tory stasis. This is a complication that can be ob tered to reduce contractility. Finally, antiarrhythmia
served for all surgical patients. Emboli from deep leg medication are prescribed if an aberrant cardiac
vein thrombus usually result in pulmonary complica rhythm is present.
tions. If the emboli are large or numerous the result Individuals with a complicated MI have a much
can be pulmonary tissue infarction and potentially longer stay in the coronary care unit, and their total
death. The incidence of pulmonary emboli has grown hospital stay time is greatly increased when com
less since early ambulation is now the rule rather than pared with the uncomplicated MI patient (Topol,
the exception. However, a pulmonary embolj must be 1988). The time in coronary care and total hospital
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4 Cardiopulmonary Pathophysiology 93
stay are dependent on the complications that occur of pressure and resistance the heart must overcome to
following the MI. Individuals with heart failure, eject blood into the systemic circulation (afterload);
thrombolytic events, or structural damage requiring and myocardial contractility, which is the amount of
surgery may be in the coronary care unit for more force the left ventricle can apply to the blood within
than 2 weeks. Total hospital stay time for compli the chamber. If any of these three variables are nega
cated MI patients may exceed 2 to 3 weeks (Topol, tively affected then cardiac output is reduced. The
1988). However, treatment following ICU discharge cause of heart failure is often decreased contractility.
is similar to that of the uncomplicated MI patient
Acute heart failure
with the goal of increasing physical activity and in
educating the patient and family in risk factor reduc If an individual has a significant myocardial infarc
tion. The major difference in Phase I cardiac rehabili tion, the contractility and pumping ability of the heart
tation for the complicated versus the uncomplicated is immediately reduced. The initial result is decreased
MI patient is the initial workload intensity, duration, cardiac output and damming of blood in the veins.
and frequency (i.e., much lower workload for compli The result is increased systemic venous pressure.
cated MI patient) (Rowe, 1989). Progression is also This acute phase, which may reduce cardiac output to
usually a bit more conservative, since the probability 40% of normal resting values is short-lived lasting
for a recurrent MI event is much greater in the com only a few seconds before the sympathetic nervous
plicated MI patient (Rowe, 1989). system is stimulated, and the parasympathetics be
come reciprocally inhibited. Sympathetic innervation
Prognosis post-myocardial infarction
causes an increase in contractility of viable myocar
Prognosis following MI is dependent on many fac dial tissue, and the increase in cardiac output may be
tors. Usually cardiovascular peliormance is reduced, 100%. In addition, sympathetic innervation also in
unless the structural damage to the ventricle is minor creases venous return, since the tone of blood vessels
(as in the case of many uncomplicated MI patients). is increased. The result is increased systemic filling
The most important factor is extent of ventricular pressure, and thus increased preload. The sympa
damage. However, with early detection of transmural thetic reflex following MI becomes maximally opera
infarction and improvement in surgical intervention tional within 30 seconds; therefore, besides some
and coronary care, acute post-MI deaths have been pain and fainting, an individual with a mild MI may
reduced (Wenger, 1984). Other critical factors in not know they just suffered a heart attack! The sym
clude remaining cardiac capacity and status of CAD. pathetic response can continue with cardiac output
Even though CAD mortality has declined in the maintained at an adequate level for quiet rest. How
United States, the disease remains the top cause of ever, the individual may still have persistent ischemic
sudden death in adults. pain that should be assessed as quickly as possible.
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94 PART I Cardiopulmonary Function in Health and Disease
again increases preload and thus cardiac output. result can be deterioration of the myocardium. As the
However, if the MI was severe, the result can be ex heart weakens, not only is systemic blood flow com
cess fluid retention. This results in detrimental effects promised, but so is the coronary system. The area
of edema and overstretching of the heart, since blood most affected is the suhendocardial region. As these
volume and venous return is too great. cells become infarcted, the heart weakens further
In addition to increased kidney retention of fluid, a until other regions of the heart also become ischemic
second process that is activated immediately follow and infarcted. The entire process described from the
ing an MI is recovery of the myocardium. New col acute to chronic stages is congestive heart failure.
lateral arteries are formed to supply the peripheral
Prognosis
portions of the infarcted region. This revasculariza
tion can assist cells that were marginally active to be The result without pharmaceutical or surgical inter
come fully functional again. In addition, the unaf vention (heart transplantation) is death. Pharmaceuti
fected myocardial cells hypertrophy. The result in a cal intervention to halt or to delay heart failure is
mild to moderate MI is a great improvement in car with diuretics to reduce fluid levels and cardiac gly
diac function that takes 6 weeks to several months, cosides such as digitalis to improve myocardial con
depending on extent of injury. tractility. This pharmacological treatment is com
bined with modification of salt and fluid intake.
Compensated and decompensated heart failure
Finally, in cases when the heart has not compensated
The final state following acute and chronic physio well and the myocardium has sufficiently weakened
logical changes is called compensated heart failure. so that cardiac output is minimal, then heart trans
In this state, the heart is able to pump blood effec plant is the only recourse. Since organ donors are not
tively, but at a reduced cardiac output compared with readily available, the number of individuals who need
the pre-MI condition. The individuals cardiac reserve new hearts far outnumber the donor organs. As de
has been greatly reduced. The cardiac reserve can be scribed previously, once the heart has had enough tis
defined as the difference between the maximum car sue damage to greatly reduce the cardiac reserve, the
diac output attainable minus the resting cardiac out prognosIs IS poor.
put. When an individual exercises or is active at a
heavy load, they experience the same symptoms of
SUMMARY
acute heart failure, because the heart is unable to sup
ply the cardiac output required of the activity. The The first portion of the chapter has described the es
symptoms include rapid heart rate, pallor, and di sential pathophysiological features of obstructive and
aphoresis. Decompensated failure occurs when the restrictive lung diseases. Obstructive disorders are
heart is so severely damaged or weakened that nor characterized by a decreased rate of airflow during
mal cardiac output can not be attained. The result is expiration (as a result of increased airway resistance).
that cardiac output is not high enough to allow for Restrictive disorders are conditions in which the in
normal renal function. Fluid continues to be accumu spiratory capacity of the lungs is restricted to less
lated and the heart is stretched more and weakened than the predicted normal.
further so that only moderate-to-Iow quantities of A knowledge of the pathophysiology of pulmonary
blood can be pumped. With unilateral left ventricle dysfunction assists the practitioner in relating the
heart failure the left ventricle fails, while the right pathophysiology to the clinical signs and symptoms,
ventricle continues to pump vigorously. The result and the appropriate treatment goals and interventions.
can be increased blood volume and pulmonary capil The second portion of this chapter has described
lary pressure in the lungs. If this occurs, fluid begins the essential pathophysiological features of CAD.
to filter into the interstitial spaces of the alveoli re CAD results from atherosclerosis. The clinical syn
sulting in pulmonary edema and suffocation. Even if dromes associated with CAD are angina, MI, and
the heart does not have a unilateral dysfunction the heart failure.
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4 Cardiopulmonary Pathophysiology 95
A knowledge of the pathophysiology of CAD en Caplan, A. (1953). Certain unusual radiological appearanccs in
chest of coal miners suffering from rheumatoid arthritis. Tho
ables the clinical practitioner to relate the etiologic
rax 8, 29-37.
factors and pathophysiology to the clinical signs and
Claypool, W., Rogers, R., & Matuschak, G. (1984). Update on the
symptoms exhibited by this patient population, and clinical diagnosis, management and pathogenesis of pulmonary
prescribes treatment. alveolar proteinosis (Phospholipidosis). Chesl 85,550-558.
Cosio, M. (1978). The relations between structural changes in
small airways and pulmonary function tests. New England
REVIEW QUESTIONS Journal of Medicine 298: 1277-1281.
C rofton, J., et al (1952). Pulmonary eosinophilia. Thorax 7, 1-35.
I. What are the two broad categories of lung disease? Crystal, R., et al (1981). Interstitial lung disease: current concepts
2. What is the major characteristic of obstructive of pathogenesis, staging and therapy. American Journal of
lung disease? Medicine 70, 542-558.
Currie, D., et al (1987). Impaired tracheobronchial clearance in
3. H o w does emphysema differ f r o m chronic
bronchiectasis. Thorax 42, 126-130.
bronchitis?
DeClerk, c., et al (1987). D-penicillamine therapy and interstitial
4. How does asthma differ from emphysema? lung disease in scleroderma. A long-term follow-up study.
5. What is the major characteristic of restrictive Arlhritis Rheumalism 30: 643-650.
lung disease? DeRemee, R. (1977). The present status of treatment of sarcoido
6. How is diffuse interstitial fibrosis diagnosed and sis: a house divided. Chesl 71, 388-393.
Dornhorst, A. (1955). Respiratory insufficiency. Lancel f,
managed?
1185-1187.
Dunnill, M. (1960). The pathology of asthma, with special refer
ence to changes in the bronchial mucosa. Jounwl of Clinical
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CHAPTER 5
Cardiopulmonary Manifestations
of Systemic Conditions
Elizabeth Dean
INTRODUCTION
lowing: musculoskeletal, connective tissue, neurolog
This chapter describes the cardiopulmonary conse ical, gastrointestinal (GJ), hepatic, renal, hematologi
quences of systemic diseases. Systemic diseases can cal, endocrine, and immunological systems. Finally,
significantly affect oxygen transport either directly or the cardiopulmonary manifestations of nutritional
in combination with primary cardiopulmonary dys d i s o r de r s , s pecifically o b e sity a n d s t a r v a t i o n
function. Although these effects can be as cata (anorexia nervosa) are presented.
strophic as those resulting from primary cardiopul Physical therapists (PTs) need to be able to predict
monary dysfunction, their presentation is often subtle the impact of systemic disease on oxygen transport
and may elude detection until significant impairment for a given patient to maximize the efficacy of their
is apparent. The pulmonary and pleural complications treatment prescriptions. Compl ications of systemic
of cardiac disease and the cardiac complications of disease appear to be increasingly prevalent. This may
pulmonary disease are described first. Then the car reflect both the aging of the population and improved
diopulmonary complications of conditions involving survival and prognosis of patients with multisystem
the following systems are described including the fol- disease. Furthermore, PTs are treating an increasing
99
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100 PART 1 Cardiopulmonary Function in Health and Disease
number of patients without refelTal, and thus may not whether treatment should be modified to avert an in
be alerted by a referring practitioner to the presence cident, or whether treatment is contraindicated all to
and significance of underlying systemic disease. gether, is essential.
Lastly, physical therapy by definition physiologically Oxygen transport can be significantly affected by
stresses the patient, therefore, the PTs must be able to dysfunction in the major organ systems of the body
identify all factors that compromise or threaten oxy (see box below). The pulmonary and pleural compli
gen transport so that treatment can be prescribed cations of heart disease and the cardiac complications
most effectively with minimal risk. of pulmonary disease are usually predictable and
A comprehensive understanding of all factors that therefore most readily detected clinically. The car
affect or threaten oxygen transport is essential particu diopulmonary complications of conditions affecting
larly in those patients who are not obviously at risk, other organ systems, however, can be more subtle, if
that is, those without overt cardiopulmonary disease. not more devastating.
The PT must be able to "red flag" a patient with an un
derlying problem for which physical therapy may be
CARDIAC CONDITIONS
contraindicated or an untoward treatment response an
ticipated. Alternatively, treatment may need to be The pulmonary complications of heart disease and the
modified or treatment responses monitored more often. cardiac complications of pulmonary disease are well
Specific diagnosis of those factors that contribute known (Scharf and Cassidy, 1989). The mechanically
to or threaten cardiopulmonary and cardiovascular inefficient heart disrupts the normal forward propul
dysfunction is, therefore, tantamount to efficacious sion of deoxygenated and oxygenated blood to and
treatment across all physical therapy specialties. The from the lungs. Because the right and left sides of the
capacity of the oxygen transport system needs to be healt are in series, a problem on one side inevitably
established to ensure that it can adequately respond to has some effect, that can lead to a problem on the
changes in metabolic demand, including those im other side, thus the healt and lung should be thought
posed by physical therapy treatment. Even though of as a single functioning unit. Disruption of the car
cardiopulmonary dysfunction may not be the primary diopulmonary circuit leads to backlogging of blood
problem, identifying whether cardiopulmonary dys and an increased volume of blood in the capacitance
function can limit a patient's response to treatment, vessels, or the veins. Right heart failure contributes to
increased central venous pressure (i.e., right atrial
pressure) and if sufficiently severe, leads to peripheral
edema in the dependent body parts. Because blood is
not being forwarded to the lungs adequately, hypox
Systems and Systemic Conditions That Affect the emia can result. In turn, hypoxic vasoconstriction of
Cardiopulmonary System and Oxygen Transport the pulmonary circulation leads to increased pul
monary vascular resistance, and hence, illcreased right
Cardiopulmonary system ventricular afterload and work. Left heart failure can
Musculoskeletal system
result in inadequate forward movement of blood
Connective tissue conditions
Collagen vascular conditions through the left heart, resulting in backlogging in the
Neurological system pulmonary circulation nd cardiogenic pulmonary
Gastrointestinal system edema. Pulmonary edema alters lung mechanics and
Hepatic system lymphatic drainage, and in turn, these effects con
Renal system
tribute to an increased risk of infection secondary to
Hematological system
Endocrine system
impaired macrophage function and bacterial growth.
Immunological system Excess pulmonary fluid arollnd the alveolar capillary
Nutritional disorders membrane creates a diffusion defect. If fluid accumu
lation is extreme, backlogging may be transmitted to
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5 Cardiopulmonary Manifestations of Systemic Conditions 101
the right side of the heart and to the periphery. Com the circulation, fluid balance in the lung is dependent
parable to excess fluid in the lungs, backup of fluid in on Starling'S forces, that is, hydrostatic and oncotic
the peripheral circulation can impair tissue perfusion. pressures. In health, several liters of fluid are ab
Other cardiovascular conditions such as systemic hy sorbed from the pleural space, thus when the balance
peltension increases systemic afterload, which in turn of these forces is disrupted in disease, considerable
increases the work of the heart thereby reducing its fluid can accumulate in the pleural space. Impaired
mechanical efficiency. alveolar expansion from pleural effusions is of clini
Pulmonary function can be significantly altered in cal concern. There is some evidence, however, to
cardiac disease (Bates, 1989). Left heart failure, for support that small effusions displace rather than com
example, is associated with accumulation of fluid in press the lung (Anthonisen and Martin, 1977).
the pulmonary interstitium. This leads to reduced cal
iber of the airways and early airway closure, air trap
PULMONARY CONDITIONS
ping and increased residual volume. The fluid can
produce reflex constriction of bronchial smooth mus Lung disease can contribute to cardiac dysfunction in
cle leading to the syndrome of cardiac asthma. The several ways. First, lung disease invariably threatens
combination of airway collapse and bronchoconstric oxygen transport by its effects on respiratory me
tion decreases total lung capacity, flow rates and chanics, and ventilation and peliusion matching. To
forced expiratory volumes. Ventilation and peliusion compensate, the heart attempts to increase cardiac
abnormalities are also associated with cardiac dis output which produces a corresponding increase in
ease. Ventilation of underperfused lung zones con cardiac work. Overall, ventilation and oxygen trans
tributes to increased ventilatory dead space, and per port is less efficient. Hypoxemia secondary to inade
fusion of underventilated lung zones leads to a right quate ventilation and perfusion matching may predis
to left shunt. In left heart failure, airway resistance pose the patient to cardiac dysrhythmias.
contributes to inhomogeneous ventilation and perfu Pleural complications can arise from either heart
sion. The normal pattern of increased ventilation to or lung disease. Both heart and lung function can be
the bases is reversed in left heart failure, that is, the compromised by altered fluid balance of the pleurae.
apices of the lungs are better ventilated (James, Fluid balance in the pleural space is comparable in
Cooper, White, and Wagner, 1971). terms of its regulation to that in the alveolar space.
With progression of the pulmonary edema, the alve Both are determined by Starling forces. Specifically,
oli become flooded resulting in reduced ventilation, and hydrostatic pressure pushes fluid into these space
significant ventilation and perfusion mismatching. The while oncotic pressure counters the effect of the hy
alveolar-arterial gradient (A-ao2 gradient) is then in drostatic forces. The net effect of these filtration and
creased, diffusing capacity decreased, and arterial par absorption forces is a minimal net filtration pressure.
tial pressure of oxygen (Pao2) decreased. Lung compli When the balance of these forces is disrupted, heart
ance is inversely related to pulmonary artery pressures and lung function can be threatened. Excessive fluid
and interstitial fluid accumulation (Saxton, Rabinowitz, floods the space usually reflecting both excessive hy
Dexter, and Haynes, 1956). The net effect of these ab drostatic pressure and diminished oncotic pressure.
normalities is both obstructive and restrictive patho The lymphatic vessels become overwhelmed and are
physiologic patterns of lung dysfunction, that is, re unable to keep the pleural space dry. Pleural fluid ac
duced forced expiratory volumes and vital capacity, cumulates and either displaces lung tissue (smaJ]-to
and an overall increase in the work of breathing. moderate effusions) or restricts opening of adjacent
Pleural effusions can result from heart disease, in alveolar sacs, causing atelectasis (severe effusions)
particular, congestive heart failure (CHF). Changes in (Brown, Zamel, and Aberman, 1978), and if suffi
intravascular pressures lead to transudative pleural ef ciently severe, may restrict cardiac filling. Pleural
fusions and cardiac injury leads to exudative effu fluid accumulation poses a unique threat to oxygen
sions. Comparable to fluid balance in other parts of transport as a result of its direct physical effect on the
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102 PART I Cardiopulmonary Function in Health and Disease
Ankylosi"g spondylitis
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5 Cardiopulmonary Manifestations of Systemic Conditions 103
compression of mediastinal structures and heart, and connective-tissue changes in the skin can lead to
impaired lymphatic drainage which depends on nor chest wall restriction. The cardiopulmonary mani
mal expiratory and inspiratory cycles (Bates, 1989). festations of connective tissue conditions are sum
marized in the box below.
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Cardiopulmonary Manifestations of Neurological Conditions
General Manifestations
Impaired mucociliary transport
Reduced mobility
Cilia dyskinesia
Incrcased mucus accumulation
Reduced cough and gag reflexes
Impaired airway protection
Increased airway resistance
Increased risk of airway obstmction
Impaired glottic closure
Increased risk of aspiration
Cerebral palsy
Stroke
Parkillsoll's disease
104
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5 Cardiopulmonary Manifestations of Systemic Conditions 105
contralateral weakness of the diaphragm and other creased muscle tone, which correspondingly increases
respiratory musc les. E pi l e ptic seizures disrupt basal and exercise oxygen consumption, resulting in
breathing, which causes hypoxemia, respiratory aci increased oxygen demands. Even though the demands
dosis, and a metabolic acidosis secondary to extreme are increased in this condition, oxygen delivery is
muscle contraction and lactate accumulation. The as compromised. For example, thoracic deformity and
sociated increase in sympathetic stimulation can pre spasm of the muscles of the chest wall and abdomen
cipitate cardiac dysrhythmias and pulmonary edema. impair breathing pattern and its efficiency (Fullford
Demyelinating diseases such as multiple sclerosis and Brown, 1976). The airways of patients with cere
result in progressive deterioration of neuromuscular bral palsy are vulnerable because of poor gag, cough,
function. The muscles of respiration become increas and swallowing reflexes. In addition, these patients
ingly involved, resulting in respiratory insufficiency often have poor saliva control, which increases the
(Cooper, Trend, and Wiles, 1985). In addition, with risk of aspiration further. Mental retardation (Bates,
increasing debility cardiopulmonary conditioning is 1989) often complicates the presentation of cerebral
reduced. Weakness of the pharyngeal musculature palsy and prevents these patients from responding ad
contributes to loss of airway protection in addition to equately to their hydration needs or being able to co
the loss of cough and gag reflexes. Aspiration is prob operate with life-preserving treatments. These patients
lematic for these patients as the disease advances. harbor numerous microorganisms, which adds further
Stroke patients may have central involvement that to their general risk of infection.
affects cardiopulmonary regulation and function, in Patients with Parkinson's disease also exhibit sig
cluding reduced electrical activity of the respiratory nificant cardiopulmonary deficits (Mehta, Wright,
muscles, or peripheral involvement such that weak and Kirby, 1978). Oxygen demand is increased com
ness, spasticity, impaired biomechanics, and gait di mensurate with increased muscle tone. Comparable
rectly affect respiratory muscle function and chest to the patients described above, patients with Parkin
waJl excursion (DeTroyer, De Beyl, and Thirion, son's also have reduced cardiopulmonary condition
1981). Abdominal muscle weakness contributes to ing levels as a result of compromised agility and abil
impaired cough effectiveness. Pharyngeal weakness ity to be independently mobile in many cases. These
contributes to sleep apnea in these patients. The com patients also have a restrictive pattern of lung disease
mon clinical presentation of unilateral involvement with most lung volumes and capacities being re
leads to a posture listing to the affected side when re duced. Chest wall rigidity impairs the normal pump
cumbent, sitting and during ambulation. This posture handle and bucket-handle movements, thus it reduces
impairs ventilation and chest wall expansion on the breathing efficiency. The energy cost of breathing is
affected side. Abdominal muscle involvement di correspondingly increased. Respiratory insufficiency
rectly affects intraabdominal pressure and the effi of Parkinson's disease likely reflects an increase in
ciency of diaphragmatic descent during contraction, tone of the respiratory muscles, chest wall rigidity, as
that is, should the abdominal muscles become flaccid well as increased parasympathetic tone and resulting
the efficiency of diaphragmatic contraction is signifi airway obstruction.
cantly reduced. Lung volumes and flow rates are re Patients with a history of poliomyelitis with or
duced proportionately giving a restrictive pattern of without cardiopulmonary complications at onset, may
lung function. Reduced activity and exercise around exhibit pulmonary limitation several decades later
the time of the stroke contributes to reduced car (Dean, Ross, Road, Courtenay, and Madill, 1991;
diopulmonary conditioning and capacity of the oxy Steljes, Kryger, Kirk, and Millar, 1990). These indi
gen transport system. Finally, a high proportion of viduals are at risk for developing respiratory insuffi
patients with strokes are hypertensive and older, a ciency as a result of respiratory muscle weakness,
population with a higher prevalence of heart disease chest wall deformity, minor infection and periods of
and atherosclerosis (Chimowitz and Mancini, 1991). relative immobility, or secondary to medical inter
Cerebral palsy is associated with significantly in ventions, (e.g., anesthesia, sedation).
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106 PART I Cardiopulmonary Function in Health and Disease
Diseases and lesions involving the brainstem can the larynx, pharynx, and tongue can lead to upper
lead to various abnormal breathing patterns. Some airway obstruction and increased airway resistance,
common breathing aberrations are Cheyne-Stokes res and interfere with maintaining a clear airway. Aspi
piration, central neurogenic hyperventilation, ap ration is a common and serious problem associated
neustic breathing, and ataxic breathing. Cerebellar and with impaired motor control of the larynx, pharynx,
basal ganglia lesions may produce respiratory muscle and tongue.
discoordination and dyspnea (Hormia, 1957; Neu,
Connolly, Schwertley, Ladwig, and Brody, 1967).
Involvement of the Autonomic Nervous System
Spinal cord lesions have a variable effect on car
diopulmonary function depending on the level of the Cardiopulmonary consequences of disorders of the
lesion. Cervical lesions result in a high mortality rate autonomic nervous system have been documented. Of
as a result of cardiopulmonary complications. All those diseases with an autonomic component, auto
lung volumes are diminished with the exception of nomic neuropathies, diabetes, and alcoholism have
total lung capacity (TLC), which over time returns to been the most studied. MUltiple system atrophy ac
normal; tidal volume (TV), which is usually pre companies autonomic failure affecting multiple sys
served (10% of TLC); and residual volume (RV), tems. Because of the anatomic proximity of the auto
which is significantly increased (Estenne and De nomic, respiratory and hypnogenic neurons and the
Troyer, 1987; Fugl-Meyer, 1971). Quadriplegic pa degeneration of these structures in this condition, dys
tients tend to have a greater diaphragmatic contribu function of the respiratory control mechanisms paral
tion to tidal ventilation compared with healthy people lels autonomic and somatic dysfunction. The respira
(Estenne and DeTroyer, 1985). In addition, these pa tory dysrhythmias that are seen in multiple system
tients have impaired cough as a result of loss of in atrophy include central, upper airway obstruction, ir
nervation and paresis of the diaphragm in some cases, regular rate, rhythm, and amplitude of respiration with
and abdominal and intercostal muscles. The contribu or without oxygen desaturation, transient uncoupling
tion of accessory muscle activity to ventilation varies of the intercostal and diaphragmatic muscle activity,
considerably (McKinley, Auchincloss, Gilbert, and prolonged periods of apnea, Cheyne-Stokes respira
Nicholas, 1969). In quadriplegia, with only the acces tion, inspiratory gasps, and transient sudden respira
sory muscles and diaphragm spared, platypnea (in tory arrest (Bannister, 1989).
creased dyspnea when upright) may occur (Dantzker, Patients with diabetes and autonomic neuropathies
1991). In the upright position, the diaphragm is flat exhibit variable effects on cardiopulmonary status.
tened and less efficient when moved downward by Postural hypotension is a complication of diabetic au
reduced abdominal pressures. tonomic neuropathy and efferent sympathetic vaso
Thoracic lesions tend to have less effect on pul motor denervation. Norepinephrine levels are gener
monary function (vital capacity and forced expiratory ally reduced in these patients. The splanchnic and
volumes in particular) than cervical lesions, and the peripheral circulations fail to constrict in response to
significance of this effect is reduced as the level of standing, thus cardiac output falls. The postural effect
the lesion is reduced. Lumbar lesions may have mini is exacerbated by reduced cardiac acceleration in pa
mal or no effect on pulmonary function; however, in tients with diabetes. Insulin has been associated with
volvement of the abdominal muscles may limit cough cardiovascular effects, including reduced plasma vol
effectiveness. ume, increased peripheral blood flow secondary to va
sodilatation, and increased heart rate. In the presence
of autonomic neuropathies, insulin can induce pos
Involvement of the Peripheral Nervous System
tural hypotension. Diabetic diarrhea secondary to ab
Disorders of the peripheral nervous system include normal gut motility can contribute to fluid loss and its
those of the motor neuron, peripheral nerve, neuromus sequelae. Cardiopulmonary changes associated with
cular junction and muscle. Neuromuscular disorders of autonomic neuropathy secondary to diabetes include
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5 Cardiopulmonary Manifestations of Systemic Conditions 107
altered ventilatory responses to hypoxia and hyper been associated with inflammatory bowel disease;
capnia, altered respiratory pattern and apneic episodes however, their occurrence is not related to the activity
during sleep, altered bronchial reactivity and impaired or therapy. Biopsy specimens have shown basement
cough (Bannister, 1989; Montserrat et aI., 1985). membrane thickening, thickening of the epithelium,
and infiltration of the underlying connective tissue
with inflammatory cells (Higenbottom, et aI., 1980).
GASTROINTESTINAL CONDITIONS
The pulmonary manifestations of pancreatitis are
The cardiopulmonary manifestations of GI dysfunc among the most important sequelae of this disease.
tion are summarized in the box below. Inflammatory Of the deaths that occur in the first week of hospital
bowel disease and pancreatitis are principal exam ization, 60% are associated with respiratory failure
ples of GI dysfunction that affects on cardiopul (Renner, Savage, Pantoja, and Renner, 1985). Prob
monary function. Aspiration is a significant cause of lems include elevated hemidiaphragms particularly
morbidity and mortality in patients with GI dysfunc on the right side, basal atelectasis, diffuse pulmonary
tion, thus it should be prevented or detected early. infiltrates appearing more often on the right side than
The pathophysiology, management, and outcome de the left side, pleural effusions on the left side more
pend on the nature of the aspirate. Several predispos than the right side, and pneumonitis. These findings
ing factors produce aspiration pneumonia including a are not specific for pancreatitis and are probably sec
decreased level of consciousness, disorders of pha ondary to localized peritonitis, subphrenic collec
ryngeal and esophageal motility, altered anatomy, tions, ascitis, pain, and abdominal distension. In
disorders of gastric and intestinal motility, and iatro chronic pancreatitis, abdominal symptoms may be re
genic factors such as surgery, nasogastric (NG) intu duced and thoracic symptoms such as dyspnea, chest
bation, and general anesthesia. pain, and cough may predominate. Chronic effusions
Inflammatory bowel disease can lead to the fol may result in pleural thickening.
lowing cardiopulmonary pathologies: vasculitis, fi
brosis, granulomatous disease, and pulmonary throm
LIVER CONDITIONS
boembolism. Bronchitis and bronchiectasis have also
Both acute and chronic liver conditions can predis
pose a patient to cardiopulmonary and cardiovascular
complications (see the box, on p. 108, at left). Hepatic
Cardiopulmonary Manifestations failure can lead to hypoxemia secondary to intrapul
of GI Conditions monary vascular dilatation and noncardiogenic pul
monary edema. Hepatopulmonary syndrome, hall
Risk of aspiration marked by intrapulmonary vascular dilatation,
Gastroesophageal reflux produces both diffusion and perfusion defects in the
lungs and is the principal reason for severe hypoxemia
Increased airway resistance
(Sherlock, 1988). The origin of pulmonary edema is
Bronchospasm
secondary to hepatic encephalopathy and cerebral
Reduced lung volumes edema (Trewby, et aI., 1978).
Elevated hemidiaphragms With respect to chronic liver conditions, car
Compression atelectasis diopulmonary manifestations have been associated
Arterial hypoxemia with cirrhosis of the liver and hepatitis. The most
common pulmonary abnormalities associated with
Alveolar capillary leak and V/Q mismatch
Alveolar hemolThagc and consolidation worsen these conditions are intrapulmonary vascular dilata
I
shunt tion with and without shunt, pulmonary hypertension,
Increased pulmonary vascular resistance airflow obstruction, chest wall deformity, pleural ef
fusions, pancinar emphysema, pleuritis, bronchitis,
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108 PART I Cardiopulmonary Function in Health and Disease
HEMATOLOGIC CONDITIONS
bronchiectasis, hypoxic vasoconstriction, and intersti Hematologic disorders that can manifest cardiopul
tial pneumonitis, fibrosis. Hypoxemia results from monary symptoms include abnormalities of the fluid
shunting, ventilation and perfusion mismatching and and cellular components of the blood, and coagu
diffusion abnormalities. lopathies (Bromberg and Ross, 1988). Cardiopul
Pleural effusions and ascites interfere with di monary manifestations of hematologic conditions are
aphragm function and present unique problems in the summarized in (the box on p. 109). The primary un
patient with Ii ver disease. Rich lymphatic connec derlying mechanisms by which these conditions dis
tions exist between the abdominal and thoracic cavi rupt gas exchange include hemorrhage, infection,
ties. Because of the rich lymphatic supply of the edema, anemia, fibrosis, and malignancies.
pleural space, ascitic fluid can flow into the pleural Abnormalities related to red blood cells and their
space. This effect is enhanced during inspiration ability to transport hemoglobin and oxygen may pro
when the intraabdominal pressure is relatively posi duce signs resembling pulmonary pathology, (e.g.,
tive and the intrapleural space is negative (Crofts, tachypnea, dyspnea, and cyanosis). Abnormalities of
1954). the deformability of red blood cells alter blood viscos
ity and pulmonary blood flow. The interstitium can be
disrupted by such factors as hemorrhage and malig
RENAL CONDITIONS
nancies. Coagulopathies disrupt the normal hemosta
Cardiopulmonary complications can result from renal sis and clotting mechanisms of the blood. Pulmonary
disease and the category of disorders referred to as pul hemorrhage and hemoptysis are common sequelae.
monary-renal syndromes (see the box above, at right). The most common causes of pulmonary hemolThage
(Rankin and Matthay, 1982; Matthay, Bromberg, and include vitamin-K deficiency, hemophilia, hepatic
Putman, 1980). The pathophysiologic characteristics failure, and disseminated intravascular coagulation.
of these disorders include alveolar hemorrhage, inter Pharmacologic agents such as platelet inhibitors and
stitial and alveolar inflammation, and involvement of anticoagulants can also result in pulmonary hemor
the pulmonary vasculature. Pulmonary function testing rhage. Pulmonary thromboemboli are common events
may detect both obstructive and restrictive abnormali with symptoms including pleuritic chest pain, dysp
ties as a result of bronchial complications, and inflam nea, and hemoptysis.
mation and hemorrhage respectively. Of the erythrocyte disorders sickle cell anemia is
In systemic illness, pathology of the lungs and probably the most common. Acute chest infection
kidneys often coexist. Like the medical management and thrombosis leading to pulmonary infarction may
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5 Cardiopulmonary Manifestations of Systemic Conditions 109
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110 PART I Cardiopulmonary Function in Health and Disease
Defective neutrophil production Western countries are obesity, and anorexia nervosa,
Colonization with gram-negative hacilli which is akin to starvation. Obesity contributes in sev
Pleural effusions and pulmonary edema with
eral ways to impaired oxygen transport (Alexander,
diabetic nephropathy
Reduced sensitivity to increases in inspiratory
1985; Bates, (989). These include alveolar hypoventi
resistive loading lation and impaired Pao2 and gas exchange as a result
Accelerated atherosclerotic vascular and cardiac of the increased weight of adipose tissue over the tho
changes racic cavity. Systemic and pulmonary blood pressures
Increased ischemic heart disease
are increased. In addition, large abdomens, and abdom
Cardiomyopathy
inal contents impinge on diaphragmatic motion, and
Increased risk of infection
can restrict diaphragmatic descent. This can lead to
Adrenal Insufficiency
compression of the dependent lung fields. Recumbency
Orthostatic symptoms
can induce respiratory insufficiency, that is positional
Reduced aerobic capacity secondary to anorexia.
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5 Cardiopulmon ary Manifestations of Systemic Conditions 111
SUMMARY
ratory muscle weakness and mechanical inefficiency of
these muscles. Work of breathing is markedly in This chapter described the cardiopulmonary conse
creased. Furthermore, in chronic cases, reactive pul quences of systemic diseases. Oxygen transport, the
monary vasoconstriction in response to chronic hypox purpose of the cardiopulmonary system, can be sig
emia contributes to right ventricular insufficiency and nificantly affected by dysfunction in virtually all
increased work of the heart and cardiomegaly. organ systems of the body. The pathophysiological
The major cardiopulmonary manifestations of consequences of diseases of the following systems on
anorexia nervosa relate to generalized weakness and oxygen transport were presented: cardiac, pulmonary,
reduced endurance of all muscles, including the res musculoskeletal, connective tissue/collagen vascular,
piratory muscles. Cough effectively is correspond neurological, gastrointestinal, hepatic, renal, hemato
ingly compromised. Oxygen transport reserve is min logic, endocrine, and immunological systems. In ad
imal. Because of poor nutrition and fluid intake, the dition, the cardiopulmonary manifestations of nutri
patient is at significant risk of anemia, fluid and elec tional disorders, i ncl ud ing obesi ty and anorex i a
trolyte imbalances, and cardiac dysrhythmias (Wil nervosa, were described.
son, et ai, 1991). Common manifestations of nutri A knowledge of these effects is essential to the
tional disorders are summarized in the box below. practice of physical therapy across all specialties in
that the prevalence of systemic disease appears to
be increasing. The p r esentation of cardiopul
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112 PART I Cardiopulmonary Function in Health and Disease
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PART II
Cardiopulmonary
Assessment
Copyrighted Material
Measurement and Documentation
Claire Peel
INTRODUCTION
surements that relate to the cardiovascular and pul
Measurement and documentation are critical com monary systems is essential for quality patient care.
ponents of the process of providing patient care. Documentation of the results of measurements,
Measurements form the basis for deciding treat the interpretation of the results and the patient care
ment strategies and therefore influence patients' re plan is important not only for reimbursement but
sponses to therapeutic interventions. Measurements also to assure communication among health care
are also used during treatment sessions to deter team members. Timely and appropriate sharing of
mine rate of progression and appropriateness of ex information on physiological responses to activity is
ercise prescriptions. Typically, therapists make a often critical for optimal medical management. Doc
series of measurements and in combination with the umentation needs to be written clearly and concisely,
results of measurements made by other health care and to include objective findings that will facilitate
professionals, form an impression of the client. The efficient and continuous care from all members of
impression includes both physical and psychosocial the health care team.
aspects. If parts of the impression are incorrect be This chapter provides a discussion of types and
cause of inaccurate measurements, then the course characteristics of measurements that are common to
of treatment may be misdirected. The result could cardiopulmonary physical therapy, followed by a dis
be treatment that is either not effective or unsafe. cussion of the process of selecting, performing, and
Consequently, knowledgc of the qualities of mea- interpreting measurements. A discussion of the pur
117
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118 PART II Cardiopulmonary Assessment
poses and types of documentation follows, including function into those with obstructive lung disease, re
suggestions for providing objective and outcome-ori strictive lung disease, or a combination of both types
ented information. of dysfunction. The categories are mutually exclusive,
that is, all patients fit into one and only one category.
The categories of a nominal measurement scale
CHARACTERISTICS OF MEASUREMENTS
are defined Llsing objective indicators that are univer
The purpose of performing a measurement is to as sally understood. For example, the classification of
sess or evaluate a characteristic or attribute of an in patients with heart failure could be based on the pri
dividual. The characteristic to be measured first must mary cause for the development of the condition (see
be defined, and the purpose of performing each mea the box below, at left). In each case, the cause could
surement must be clear. Therapists then can select the be determined by diagnostic testing such as angiogra
most appropriate method of measurement given the phy or echocardiography. Clear descriptions of the
available resources and their clinical skills. criteria for inclusion in each category facilitate clini
cians' agreement on the assignment of patients to cat
egories. A high percentage of agreement indicates
levels or Types of Measurements
high interrater reliability.
Measurements can be described according to their
Ordinal
type or level of measurement. There are four levels of
measurements which are nominal, ordinal, interval Ordinal measurements are similar to nominal measure
and ratio (Rothstein, Echternach, 1993). Recognizing ments with the exception that the categories are or
the level of measurement aids in the understanding dered or ranked. The categories in an ordinal scale in
and interpretation of the result. dicate more or less of an attribute. The scale for rating
angina is an example of an ordinal scale (Pollock,
Nominal Willmore, and Fox, 1978) (see the box below, at right).
Objects or people are often placed in categories ac Each category is defined and a rating of grade I angina
cording to specific characteristics. If the categories is less than a rating of grade 4. In an ordinal scale, the
have no rank or order, then the measurement is consid differences between consecutive ratings are not neces-
ered nominal. An example of a nominal measurement
is the classification of patients with pulmonary dys-
Allgina Scale
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6 Measurement and Documentation 119
sarily equal. The difference between grade 1 angina sured using either an interval or a ratio scale. The
and grade 2 is not necessarily the same as between Fahrenheit temperature scale assigns the zero point to
grade 3 and grade 4 angina. Consequently, if num the temperature at which water freezes, whereas the
bers are assigned to categories, they can be used to Kelvin scale assigns the zero point to an absence of
represent rank, but cannot be subjected to mathemati heat. The Fahrenheit scale is an example of an inter
cal operations. Averaging angina scores is incorrect val level of measurement, and the Kelvin scale is a
because by averaging, it is assumed that there are ratio level of measurement.
equal intervals between categories. Measuring force production using an isokinetic dy
Categorical measurements are considered ordinal namometer is an example of an interval measurement
if being assigned to a specific category is considered commonly used in physical therapy. Patients may be
"better than" or "worse than" another category. For able to generate muscle tension and move an extrem
example, patients with angina could be classified as ity, but register a score of zero because they cannot
having either stable or unstable angina. This mea move as fast as the dynamometer. Interval measure
surement would be considered ordinal, because stable ments can have negative values, and can be subjected
angina usually is considered a better condition to to some arithmetic operations. Adding and subtracting
have compared with unstable angina (Hurst, 1990). values is logical. A patient who generates 10 ft-lbs at
one session and 20 ft-Ibs at the following session in
Ratio
creased their torque production by 10 ft-Ibs. Interval
Ratio measurements have scales with units that are values cannot be subjected to division or multiplica
equal in size, and have a zero point that indicates ab tion. It cannot be stated that the patient generated
sence of the attribute that is being measured. Exam twice as much torque on the second session compared
ples of ratio measurements that are used in cardiopul with the first session because it cannot be assumed
monary physical therapy include vital capacity, that a reading of zero indicated no torque production.
cardiac output, and oxygen consumption. Ratio mea
surements are always positive values, and can be sub
Reliability
jected to all arithmetic operations. For example, an
aerobic capacity of 4 Llmin is twice as great as an Reliability is defined as the consistency or repro
aerobic capacity of 2 Llmin. ducibility of a measurement. Ideally, if attempting to
When deciding if a measurement is ratio level or. measure a specific attribute, the value of the measure
not, the attribute that is being measured is defined. ment should change only when the attlibute changes.
If the zero point indicates absence of the attribute, However, all measurements have some element of
then the scale would be considered ratio. For exam error that contributes to the variability of the measure
ple, cardiac output can be defined as the amount of ment. When the error is relatively high, the value of
blood in liters ejected from the left ventricle over a the measurement can change, even though the attribute
I -minute period. A measurement of zero cardiac has not changed. Believing that a change occurred
output would be absence of the characteristic, or no when it did not could result in an inaccurate clinical
blood ejected from the left ventricle. decision related to treatment planning or progression.
Many factors contribute to variability in the results
Interval
of measurements. The characteristic being measured
Measurements that are at interval level have units on may demonstrate a certain degree of variability. Both
a scale with equal distance between consecutive mea blood pressure and heart rate vary depending on both
surements. Interval measurements are differentiated mental and physical factors such as body position,
from ratio measurements, because the zero point is hydration level, anxiety and time of day. For these at
arbitrary rather than absolute. An arbitrary zero point tributes, multiple measurements often are used to
is one that does not mean an absence of the character provide the best estimate of the patient's true heart
istic that is being measured. Temperature can be mea rate and blood pressure.
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120 PART II Cardiopulmonary Assessment
Another factor that contributes to the variability of a ment must possess a certain degree of validity. Mea
measurement is changes in the testing instrument. surements can be reliable but not valid. For example,
Testing instruments may vary in their readings because measurements made using bioelectrical impedance
of changes in environmental conditions or malfunction analyses have been shown to be valid for the estima
of parts of the instrument. Instruments should be cali tion of total body water, but uncertainty exists as to the
brated, that is, compared with a known standard, on a validity of estimates of percent body fat made with this
regular basis to assure accuracy of the readings. Some device (Kusher and Schoeller, 1986).
instruments are relatively easy to calibrate. For exam There are various types of validity. Of importance
ple, values obtained using aneroid blood pressure de in clinical practice are concurTent, predictive, and pre
vices can easily be compared with values obtained scriptive validity. Concurrent validity is when a mea
using mercury manometers. Values obtained using ei surement accurately reflects measurements made with
ther palpation or a heart rate monitor can be compared an accepted standard. Comparing bioelectrical imped
with values obtained from BCG recordings. The mer ance measurements for estimating percent body fat
cury manometer and the electrocardiograph (BCG) with estimates made from hydrostatic weighing is an
would be considered the standard method of measure example of determ.ining conCUITent validity. In this ex
ment. Other devices, such as cycle ergometers, are ample, hydrostatic weighing would be considered the
more difficult to calibrate, and the usual approach is to "gold" or accepted standard. Measurements with pre
rely on the manufacturer's specifications as to the ac dictive validity can be used to estimate the probability
curacy of the work rate readings. of occurrence of a future event. Screening tests often
A third factor contributing to measurement vari involve measurements that are used to predict future
ability is differences in the methods that therapists events. For example, by identifying people with risk
use to make measurements. If a result is consistent factors for coronary artery disease (CAD), a prediction
when one therapist repeats a measurement, then the is made that the likelihood of developing CAD is
measurement is said to have high intrarater reliabil higher than normal. Measurements with prescriptive
ity. Measurements that are consistent when multiple validity provide a guide to the direction of treatment.
therapists perform the measurement under the same The categorical measurement of determining a per
conditions are said to have high interrater reliability. son's risk for a future coronary event is a measurement
Often, measurements have high interrater reliability, that would need to have predictive validity. By classi
but lower intrarater reliability because therapists vary fying patients into high vs. low risk categories based
in the specific methods of making the measurement. on the results of a diagnostic exercise test, the inten
For example, a slight variation in the anatomical site sity, and rate of progression of treatment is determined.
used for measuring skinfold thickness can produce The accuracy of various types of exercise tests
relatively large differences in percent fat estimates often is described by reporting sensitivity and speci
(Ruiz, Colley, and Hamilton, 1971). Interrater relia ficity. Sensitivity is the ability of a test to identify in
bility is important in clinical settings where a patient dividuals who are "positive," or who have the charac
may be evaluated and treated by more than one thera teristic that is being measured. Specificity is the
pist. If the interrater reliability of a measurement is ability of a test to identify individuals who are "nega
low, then changes in the patient over time may not be tive," or who do not have the characteristic. If a test
accurately reflected. produces a high number of "false positive" results,
then the sensitivity will be low. A false positive result
means that the test result was positive but the charac
Validity
teristic was absent. Young women often have posi
Valid measurements are those that provide meaningful tive stress test results but do not have CAD. The con
information and that accurately reflect the characteris sequence of a false positive test result could be
tic for which the measurement is intended. For a mea unnecessary treatment. A high number of "false neg
surement to be useful in a clinical setting, the measure ative" results would produce a low specificity. A
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6 Measurement and Documentation 121
false negative result would be a negative test result, measurement, subjective measurements usually have
even though the disease or characteristic is present. lower interrater reliability compared to objective mea
The consequence of a false negative test result is not surements (Rothstein and Echtemach, 1993).
receiving treatment when it is indicated. Objective measurements are not affected by the per
son performing the measurement, that is, these mea
surements do not involve judgement of the measurer.
Objective and Subjective Measurements
Heart rate measured by a computerized ECG system is
Measurements vary in degree of subjectivity vs. objec an example of an objective measurement. Other exam
tivity. Subjective measurements are those that are af ples include measurement of blood pressure using an
fected in some way by the person taking the measure intraarterial catheter or oxygen consumption using a
ment, that is, the measurer must make a judgment as to metabolic system. Objective measurements are not nec
the value assigned. The assessment of a patient's essarily accurate, but usually have high intelTater relia
breath sounds is influenced by many factors including bility (Rothstein, and Echtemach, 1993).
the therapist's choice of terminology for describing the Most measurements cannot be classified as either
findings, their perception of normal breath sounds, and objective or subjective. The quality of a measurement
their hearing acuity. The grading of functional skills can be placed on a continuum based on the degree of
may be influenced by the therapist's interpretation of reliability, as shown in Figure 6-\. The attribute or
what constitutes minimal vs. moderate assistance. Be characteristic that is being measured also can be
cause of the influence of the person performing the viewed as a subjective o r objective phenomena
Phenomena Being
Measured
Objective
o 100
SO 00
Reliability Continuum
Subjective
o 100
SS OS
FIGURE 6-1
Illustration of the relationship between the quality of a measurement as being subjective or
objective, and the phenomenon being measured. The scales indicate that the objectivity of a
measurement, or reliability, lies along a continuum. For example, a subjective phenomenon may be
measured subjectively (subjective sign [SS]) or objectively (objective sign [OS]). (From Rothstein
1M: On defining subjective and objective measurements. Phys Ther 69:577-579, 1989.)
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122 PART II Cardiopulmonary Assessment
(Rothstein, 1989). A subjective attribute such as pain stage post-MI could provide information to formulate
can be measured in either a subjective manner with a an exercise prescription. However, the risks of per
low degree of reliability, or in an objective manner forming this procedure at this time in the recovery
with a high degree of reliability. period may outweigh the benefits.
At the initial session with a client, how do therapists When performing mcasurements, care must be
decide on the measurements to be performed? And taken to use procedures that can be replicated for
what additional measurements need to be peltormed future comparisons. Time must be taken to ensure
during the course of treatment and at follow-up evalu that conditions are optimal and that the patient is
ations? Many factors influence the choice of the thera informed of his or her part in the activity. For ex
pist, including information obtained from the medical ample, measuring blood pressure in a noisy treat
record and the patient interview, and knowledge of ment area immediately when the patient arrives for
available treatment options. Therapists also must an appointment may not provide an accurate mea
strive for efficiency and not repeat tests that have been surement of resting or baseline bJood pressure.
performed by other health care professionals. Charac Documenting the conditions in which a measure
teristics or qualities of measurements, such as reliabil ment was made also is important. Conditions may
ity and validity also influence the therapist's decision. include, but are not limited to, time of day, room
Medical and personal information about the client temperature, recent activities performed by the pa
will be a plimary factor guiding the selection of mea tient, and type of measuring device.
surements. For example, appropriate measurements Measurements should be made with an objective
differ for a patient with an acute MI vs. a patient who and open mind, that is, without anticipating the result of
is 3 weeks post-MI. Other factors to consider include the measurement. A measurement that is approached
the size of the infarction and associated complications with a preconceived idea of the outcome may be af
such as an-hythmias, heart failure, or angina. Informa fected by the therapist's expectations. Having confi
tion collected during the patient interview also may dence in the results of one's measurements is impor
guide the selection. For example, for patients who dis tant, and is developed as clinical skills are developed.
play anxiety when walking on a treadmill is discussed, In clinics where more than one therapist is likely
another mode of exercise may be more appropriate. to evaluate or treat a patient, written procedures for
Measurements need to be selected that are appropriate performing measurements are needed. Therapists also
to the specific pathology, the severity of the condition, need to review the written procedures on a regular
and other characteristics unique to the patient. basis and practice performing the measurements as a
Another important factor to consider in selecting group. Practicing together is especially important for
measurements is the application of the information. therapists who are new to the clinic. The interrater re
Every measurement should contribute to the deci liability for commonly used measurements then can
sions made by the therapist on the course and pro be determined. If the reliability is low, the written
gression of treatment. Measurements that do not con procedures may need to be revised to assure optimal
tribute to the assessment of the patient result in an consistency of measurement.
inefficient use of the therapist's time and add unnec
essary costs to medical care.
INTERPRETING MEASUREMENTS
Another factor that i nf! uences the selection of
measurements is the risk-benefit ratio. How do risks Interpreting the results of measurements often is a
of conducting a test or measurement relate to the difficult task. Usually patients' problems are under
value of the information gained? Subjecting a patient stood not by reviewing the results of a single mea
to a symptom-limited exercise test during the acute surement, but by viewing the relationships between
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6 Measurement and Documentation 123
the results of several measurements. For example, and viewed in the context of the patient's personal
the finding that blood pressure does not increase goals. Therapists develop a picture of the severity of the
with activity by itself may not be considered abnor cardiopulmonary condition, the stage of recovery, and
mal, if the activity level is low and the patient is tak the presence of coexisting conditions. A treatment plan
ing a beta receptor antagonist medication. The find is developed based on the composite of findings. The
ing of no increase in blood pressure with signs and plan is implemented and is continuously checked for
symptoms of exercise intolerance during moderate appropriate direction by measurements made during
level activity in another patient may be indicative of treatment sessions. Because of the progressive nature of
inadequate cardiac output. many of the conditions that affect the cardiovascular
A knowledge of what is "normal" is important to and pulmonary systems, each treatment session can be
be able to interpret the results of tests. For some mea viewed as a reassessment.
surements, normal values are well-defined. Measure
ments of resting blood pressure, cholesterol, and
PURPOSES OF DOCUMENTATION
blood glucose have defined categories of normal,
borderline, and elevated. For other measurements, To be useful, measurements need to be recorded or
population normative standards are not well-defined. documented in a concise and organized manner.
For example, what is the normal increase in heart rate Measurements that remain in the mind of the evalua
when walking at 3.5 mph on a level surt'ace? Values tor often are forgotten or not remembered accurately.
for individuals differ, depending on age, medications, Documentation is becoming more important to assist
fitness level, and walking efficiency. Results need to and to maximize reimbursement, as well as to facili
be interpreted by considering these factors and patho tate efficiency of care through communication be
logical conditions if present. Each individual has tween health care professionals.
their own "normal" or usual response, and variations Documentation includes information about evalua
from this value could be considered abnormal. tive findings, the assessment of the patient's condi
Interpreting the results of tests is similar to putting tion, and the plan for future care. Reasons for docu
the pieces of a puzzle together to create a picture of mentation include the following:
the patient and their limitations. Information is col I. To provide information for other therapists, as
lected from several sources, including the medical sistants, or aides who may evaluate and/or treat
record, patient interview and physical therapy evalua the client.
tion. Measurements performed and interpreted by 2. To provide data for comparison for follow-up
other health care professionals can be obtained from visits.
the medical record and include chest x-ray, blood 3. To provide data to determine treatment effec
analyses, and echocardiography. During an interview, tiveness and efficiency through collection of in
the patient reports information about his cunent and formation on the results or outcomes of various
past medical problems. It is important to be sensitive types of care.
to the patient's feelings about his condition, noting 4. To assist therapists in organizing findings to fa
his stage of emotional recovery. Detecting attitudes cilitate logical decisions on the treatment ap
related to changing lifestyle habits also is important. proach and overall care plan.
After the interview, the therapist should have a sense
of the patient as a person and begin to plan a strategy
TYPES OF DOCUMENTATION
for optimizing his or her physical function.
Measurements made during the physical examina Systems for documenting information vary between
tion may include physiological responses to activity, facilities. In acute care hospitals, physical therapy
breathing patterns, ventilatory capacity, and breath notes may be included as a part of the patient's
sounds. The results of these measurements are inte comprehensive medical record. In other facilities
grated with results collected during the chart review such as private practice clinics the patient's record
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124 PART II Cardiopulmonary Assessment
may consist of physical therapy notes and medical ambulation," and "abnormal tone." Written definitions
information that is relative to the physical therapy of commonly used terms that include examples of
care plan. Whatever the system, notes can be classi characteristics that illustrate the definition can help to
fied according to the timing and purpose of the doc decrease confusion.
umentation, using the following categories: Notes also need to clearly demonstrate the need
I. Initial evaluation, assessment, and plan for professional skills if a physical therapist is per
2. Interim or progress notes forming the evaluation and/or treatment. Activities
3. Discharge notes that can be performed by physical therapists assis
4. Follow-up or reevaluation notes tants, aides, nursing personnel or family members
The initial note usually is the longest, containing in need to be delegated to the appropriate individual. In
formation on the reason for referral, other medical addition, patients can be instructed in those activities
conditions and information that could affect physical in which they can pelform independently.
therapy management, data collected during the pa Another time in which documentation is essential
tient interview and physical examination, an assess is when an unusual or adverse event occurs. For ex
ment or interpretation of the findings and the care ample, abnormal responses to activity that may ap
plan. Interim or progress notes record short-term pear relatively benign are important to record. Abnor
changes in the patient's status, and typically are writ mal responses may include dizziness, anginal or
ten on a daily or weekly basis. The discharge note musculoskeletal pain, or arrhythmias. An unusually
records the specific outcomes of treatment, the plan high or low heart rate or blood pressure response also
for discharge, including home program, and the plan should be noted. Combined with findings noted by
for follow-up. At follow-up visits, a note is written to the patient or other health care professionals, these
assess changes since the time of discharge and plans results may indicate significant changes in the pa
for additional treatment. tient's cardiopulmonary status.
The organization of documentation varies be
tween facilities. Many facilities use the SOAP (sub
GENERAL GUIDELINES FOR CONTENT
jective, objective, assessment, plan) format (Ketten
AND ORGANIZATION
bach, 1990). Other facilities have modified this
Writing notes in a clear and concise format is impor format, with the same information organized in a dif
tant so that information is conveyed accurately. Exam ferent w a y . The following section presents an
ples of unclear notes are ones in which the handwriting overview of relevant subjective and objective infor
is illegible, or that contain vague statements that could mation, and a description of items to include in the
be interpreted in more than one way. Concise notes are assessment and plan.
more likely to be read by other health care profession
als. In most clinicians' schedules, time is not available
Subjective Information
to read through extensive information about a patient
that may not be relevant. A concise note only includes Subjective information contains a degree of judge
essential infOImation in a writing style that is clear and ment or interpretation by the person reporting the in
does not include unnecessary phrases. Another impor formation. The patient and family's perceptions of
tant rule is to use only standard or accepted abbrevia their cardiac or pulmonary condition are considered
tions. Facilities have lists of approved abbreviations subjective information. In the initial note, descrip
for that facility. The list should be available to those tions of pain or discomfort that may be associated
who write, read, and review records. Within a physical with either a cardiac event or a pulmonary complica
therapy department, common terms need to be clearly tion are important to include. Some of the informa
defined and used in a consistent manner by all staff. tion reported by the patient may be objective, such as
Terms that often generate confusion and carry multiple blood cholesterol levels, resting blood pressure val
meanings include "minimally assisted," "functional ues or number of cigarettes smoked per day.
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6 Measurement and Documentation 125
In the interim note, it is impoltant to record the pa The description of the evaluation and treatment
tient's responses to treatment including feelings of results needs to include specific information on the
angina, dyspnea, or fatigue. Whether a prescribed home activity, or exercise stress, and on the physiological
or ward activity program is performed and the patient's responses. Components of the activity description in
subjective responses to the program also are important clude the following:
to note. Any reported changes in the ability to function I. Mode of activity (corridor or track walking,
either at home or in the community are important to lower extremity cycling)
record. The most impoltant subjective finding to report 2. Work level or rate (mph, percent grade, esti
in the discharge note is whether the patient believes mated resting metabolic rate level)
personal treatment goals were achieved. 3. Duration of activity at each work level
The description of the activities should be written
clearly so that the workload can be reproduced. The
Objective Information
responses to activity include changes in heart rate and
Measurable or observable information that is col rhythm, blood pressure, respiratory rate, oxygen satu
lected during the interview, evaluation, and treat ration levels, and heart and breath sounds as com
ment is considered objective. Information from the pared with from preactivity to either during or imme
medical record may be included if it is relevant to diately after activity. Signs of exercise intolerance,
the patient's current condition. To be relevant, the such as changes in skin color, incoordination, and
information should have potential impact on the di sweating, also need to be documented. Whether the
rection of the evaluation and treatment of the patient, patient used oxygen during treatment, or required
such as current medications and results of diagnostic physical assistance also should be noted. By objec
tests. Results uJ" tests and measurements conducted tively recording the activity prescription and the
as a part of the initial evaluation are objective infor physiological responses, therapists can estimate the
mation. A description of the treatment that is pro patient's activity tolerance.
vided, and the patient's physiological responses to
treatment also are considered objective information.
Assessment
When recording information collected during the
evaluation, the results of various tests can be cate The purpose of the assessment part of a note is to list
gorized as impairments or as functional limitations. the client's major problem(s), identify treatment goals
An impairment is an abnormality of physiological or outcomes, and provide an interpretation of the sub
function or anatomical structure at the tissue, organ jective and objective findings. The problem list is lim
or body system level (Jette, 1994). Examples of im ited to problems that can be addressed by physical
pairments include decreases in muscle strength or therapy. Problems can be listed in order of priority
range of motion, or abnormal heart rate and blood and stated in functional terms. For example, stating
pressure values. A functional limitation is a restric "patient unable to c1imb stairs because of abnormal
tion in performance at the level of the whole person ECG responses and dizziness," rather than stating
(Jette, 1994). Functional Ii mi tations can be attrib "abnormal ECG response during activity."
uted to physical, social, cognitive, or emotional fac Goals are the outcomes to be achieved by paltici
tors. Examples of functional limitations include the pating in a physical therapy program and are generated
inability to dress, transfer, ambul ate, or climb by the therapist and patient in consultation. Goals are
stairs. Improvements in functional status usually stated in functional terms as to what the patient will be
are of primary interest to patients and families and able to do at discharge. The following is an example:
to those who reimburse for health care. Measure
ments of impairments arc important, because they Patient will be able to carry one 25-lb. bag a distance of 50
assist therapists in deciphering the causes or rea feet with appropriate heart rate and rhythm responses,
sons for limitations in function. within 2 weeks.
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126 PART II Cardiopulmonary Assessment
To be able to detennine if a goal has been met, the ther mation from records can be organized into sections
apist must be able to observe or to measure the activity. describing subjective and objective information, as
Therapists also estimate the time that it will take to sessment or interpretation of the findings, and the
achieve the outcome. In the discharge note, whether care plan. Subjective and objective information is
each goal has been met is stated. If a goal has not been collected during an interview, medical record review,
achieved, then a reason or explanation is provided. and evaluation and/or treatment session. The assess
The assessment also includes a brief interpretation ment provides an interpretation of the subjective and
of the subjective and objective findings. Therapists objective findings, and states the desired treatment
can use this section to state their "clinical hypothe outcomes. A specific plan to achieve the outcomes
sis," or explanation of the primary problem that pro then is described. Documentation can be viewed as a
duces the objective and subjective findings. The ini way to assist therapists to organize their findings, re
t i a l n o t e m a y i n c l u d e statemen t s about the flect on the significance of the findings, and generate
individual's potential t o succeed i n a rehabilitation an efficient and comprehensive care plan.
program, or reasons for not performing tests that
would typically be performed with individuals with
REVIEW QUESTIONS
similar diagnoses. Whether the patient needs to be re
ferred to other health care professionals or to commu l. Describe and give examples of nominal, ordinal,
nity services also can be included. ratio and interval measurements.
2. Identify three factors that contribute to the vari
ability of measurements.
Plan
3. Define sensitivity and specificity of tests.
The plan provides a description of the approach that 4. Differentiate between objective and subjective
will be taken to assist the patient in achieving the measurements.
stated goals. The plan may include a description of S. Identify four purposes for documenting the re
treatment that can be provided, education for the pa sults of evaluation and treatment sessions.
tient and/or family, and referrals to other services.
Descriptions of home or ward programs should be in
References
cluded in the plan. At discharge from an inpatient
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ing and plans for follow-up. At discharge from an angina pectoris and angina equivalents. In Hurst, J.W., Schlant,
R.C., Rackley, C.E., Sonnonblick, E.H., & Wenger, N.K.
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(Eds.). The hean Oth ed.). New York: McGraw-HilI.
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Jelle, A . M. (1994). Physical disablement concepts for physical
therapy research and practice. Physical Therapy 74, 380-386.
Keuenbach, G. (J990). Writing S.O.A.P. notes. Philadelphia: FA Davis.
SUMMARY
Kusher, R.F. & Schoeller, D.A. (J986). Estimation of total body
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Measurement and documentation are important com
Clinical Nutrition. 44, 417-424.
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Pollock, M.L., Wilmore, J.H., & Fox, S.M. (1978). Health and it
f
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information about patient characteristics that is Rothstein, 1.M. (J989). On defining subjective and objective mea
needed to determine appropriate directions for treat surements. Physical Therapy 69, 577-579.
Rothstein, J .M .. & Echternach, J. L. (1993). Primer on measure
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ment: An introductory guide to measuremelll issues. Alexan
allows comparison of patient characteristics at varied
dria, V A: American Physical Therapy Association.
points in time. The recording, or documentation, of Ruiz, L.,& Colley, J.R.T. & Hamilton, P.J.S. (1971). Measurement of
the results of measurements and other information triceps skin fold thickness: An investigation of sources of variation.
about the patient serves as a legal record. Although British Joul11al of Preventive and Social Medicine 25, 165-167.
Copyrighted Material
History
Willy E. Hammon
INTRODUCTION
words and pace (Hurst, et ai, 1990). If the therapist ap
The value of the history depends in large part on the pears hurried, distracted, preoccupied, irritated, or un
skill of the interviewer. When eliciting the history caring; is often interrupted; or fails to be an attentive lis
from a patient, therapists must be alert to recognize tener, the patient-therapist relationship will likely suffer.
the symptoms that are indicative of cardiac and pul The interviewer must be careful not to allow per
monary disease. This information is then used in the sonal feelings about the patient's grooming, appear
decision-making process to select the most appropri ance, demeanor, and behavior during the interview to
ate intervention for the individual. unduly question the validity of the chief complaints
(Birdwell, 1993). By the time the patient is referred
for physical therapy, he or she may have seen one or
THE INTERVIEW
more physicians, have been subjected to a number of
Obtaining a thorough and accurate patient history is noninvasive or invasive studies, or have been pre
truly an art. One imponant goal of histOlY taking is to scribed oral or inhaled medications with variable or
establish a good patient-therapist rapport. The patient unsatisfactory alleviation of symptoms. The patient is
must be allowed to explain the history in his or her own likely to manifest a degree of anxiety and frustration.
127
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128 PART n Cardiopulmonary Assessment
Therefore the therapist's approach, history-taking and 2. Whether the treatment order is narrow or
interviewing style is important for gaining the pa broad in scope.
tient's confidence and cooperation. 3. The acuteness of the patient's illness, level of
The patient history interview can be divided into consciousness, and his ability to provide ac
the data-gathering and interpretative sections (Snider, curate information.
1994). The data-gathering segment begins with ask This chapter presents a comprehensive approach to
ing why the patient has sought medical attention and history taking. Therapists may find part or all of this
has been referred for physical therapy services. In information applicable, depending on their particular
other words, what is the patient's chief complaint circumstances.
the symptom that caused the patient to seek help?
Each chief complaint should be carefully ex
QUESTIONNAIRES
plored. Supplementary questions should be nonlead
ing, using words the patient can easily understand. Printed symptom or medical questionnaires can be ben
This allows the interviewer to determine the signifi eficial or detrimental to the patient-therapist relation
cance of the complaint. An in-depth knowledge of ship, depending on how they are used. Questionnaires
cardiopulmonary pathophysiology allows the thera can expedite the data-gathering portion of the initial
pist to almost simultaneously gather data about the visit by allowing the patient to note in advance, all
patient's symptoms and to interpret the likely type of symptoms, medical conditions, surgeries, occupalions,
cardiopulmonary dysfunction that exists. This in turn medications, and other factors that may influence phys
serves as a basis for the therapist to begin to select ical therapy intervention. They can reduce the amount
the appropriate assessment and treatment modalities of nontreatment time therapists may otherwise spend
for the individual. inquiring about irrelevant symptoms and conditions.
It is important to remember that patient satisfaction Pri nted questionnaires also allow patients sufficient
is greatest if the patient is allowed to fully express time to recall relevant informalion and respond more
major concerns without interrupting. In addition, the accurately than they often do in an interview selting
risk of missing what is really of greatest concern to the (Miller, 1980). Used in this way, a printed question
patient is reduced if the patient is allowed sufficient naire can be a valuable tool for expediting a compre
time to describe it in his or her own words. Studies hensive evaluation of cardiopulmonary patients.
have shown this usually only takes from I to 3 minutes. However, if questionnaires are used improperly,
The patient's view of what is the problem and his or they can depersonalize the history-taking portion of
her suggestions for addressing the problem should be in the initial visit (Hurst, et ai, 1990). If the therapist al
cluded in the interview. Patient satisfaction is improved lows the printed form to become a substitute for in
by his or her involvement in the interview as well as teraction with the patient, patient satisfaction will be
later in the establishment of short- and long-term goals. low and the patient-therapist relationship will suffer.
The depth of the history taken by the physical ther
apist (PT) can vary according to the following factors:
DYSPNEA
1. Whether the individual is an inpatient or an
out patient. Many inpatients have detailed Dyspnea, breathlessness or shortness of breath, can be
medical records available for the therapist to re defined as the sensation of difficullY in breathing
view. This significantly reduces the amount of (George, 1990). It is one of the most common reasons
information the therapist needs to obtain from that patients seek medical attention. Dyspnea is difficult
the patient during an interview. If the informa to quantitate, because it is subjective and at times is
tion in the chart is scant, or if the individual is normal (i.e., at high altitudes, and during or following
an outpatient with only a treatment referral and vigorous exercise). Dyspnea is a symptom of cardiac
little or no medical records available, the thera and pulmonary diseases, as well as other conditions.
pist should obtain a more detailed history. When a patient complains of shortness of breath or
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7 History 129
FIGURE 7-1
Schematic illustration of the oxygen transport system, which involves the interaction between the
respiratory, cardiovascular, and musculoskeletal systems. (Reprinted with permission from Mahler
D: Dyspnea: diagnosis and management. Clirz Chest Med 8 [2),215-230,1987.)
breathlessness, it should be noted that this complaint in the work of breathing, and (3) an abnormality in the
is often unrelated to the patient's arterial oxygen ventilatory system itself (George, 1990).
level (Pao2). Many times, it appears that altered me An increased awareness of normal breathing is
chanical factors during breathing contribute to the usually related to anxiety (Miller, 1980). The patient
sensation of breathlessness (Mahler, 1987). Numer commonly complains of "not getting a deep enough
ous receptors that have a role in sensing dyspnea breath," a feeling of "smothering," or "not getting air
have been identified and include vagal receptors down in the right places" (Szidan and Fishman,
(e.g., irritant, stretch, and J-receptors), chemorecep 1988). These sensations have been designated as psy
tors, proprioceptive receptors (tendon organs, muscle chogenic dyspnea. The patient's breathing pattern is
spindles, joint and/or skin receptors), and upper air irregular, with frequent sighs. When severe, it is asso
way receptors (Snider, 1994). ciated with tingling of the hands and feet, circumoral
Analyzing the oxygen transpOit system (Figure 7-1) numbness, and lightheadedness. Coaching the patient
can help the therapist deterrrune the likely cause of each to hyperventilate and to reproduce the symptoms may
patient's dyspnea and the most appropriate physical help the patient better understand the cause of these
therapy intervention. The delivery of oxygen from am symptoms and how to control them (Miller, 1980).
bient air to the mitochondrion within the cell depends The hyperventilation syndrome is properly diagnosed
on the intact interaction of the respiratory, cardiovascu only after organic causes have been excluded and
lar, and muscular systems. Also, carbOn dioxide (C02) pulmonary function tests indicate normal respiratory
is eliminated in the opposite direction. Dyspnea can be mechanics and Pao2.
caused by dysfunction in any of the systems. The second cause of dyspnea is an increase in the
Dyspnea commonly occurs when the body's re work of breathing. Greater inspiratory pressures must
quirement for breathing (ventilation) exceeds the be generated by the respiratory muscles to move air in
body's capacity to provide (Snider, 1994). In other and out of the lungs when the mechanical properties
words, the symptom varies directly with the body's of the lungs have changed. This may be related to an
demand for ventilation and inversely with ventila increase in lung water resulting from cardiac disease
tory capacity. or the high cardiac output of anemia. A loss of com
There are three basic causes of dyspnea: (I) an in pliance (increased lung stiffness) because of diffuse
creased awareness of normal breathing, (2) an increase inflammatory or fibrotic lung disease often causes
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130 PART II Cardiopulmonary Assessment
shortness of breath. Small or large airways obstruction I. Are you short of breath at rest? If the answer
as a result of bronchoconstriction, sputum, inflamma is yes, it suggests a severe physiological dys
tion, and other effects commonly produces dyspnea. function. The patient likely needs prompt eval
The third cause of dyspnea is an abnormality in uation by a physician if this is of recent onset
the ventilatory apparatus or pump. The ventilatory and has not had a medical workup.
apparatus consists of the thoracic cage, respiratory 2. Do you have chest pain'? If so what part of
muscles, and nerves. Any of these may become dys your chest? Unilateral localized chest pain
functional. Thoracic cage abnormalities include raises the possibility of spontaneous pneumoth
kyphoscoliosis, extreme obesity, and large pleural ef orax, pulmonary embolism, or chest trauma.
fusions. Diseases of the respiratory muscles include 3. What were you doing immediately before or
polymyositis and muscular dystrophy. Neurologic ab at the time of onset of shortness of breath?
normalities include spinal cord injuries, phrenic nerve Approximately 75% of spontaneous pneumotho
injuries, brachial plexus neuropathy, ascending races occur during sedentary activity, 20% dur
polyneuritis (GuiJlain-Barre syndrome), myasthenia ing some strenuous activity, and 5% are related
gravis, amyotrophic lateral sclerosis, poliomyelitis, to coughing or sneezing. A history of immobi
neurotoxins, and exposure to paralytic agents. lization of a lower extremity, recent surgery, bed
The time course of the appearance and progression rest, travel requiring prolonged sitting, obesity,
of dyspnea should be identified (Sharf, 1989). Acute CHF, venous disease of the lower extremities,
dyspnea is common in pulmonary embolism, pneu are all risk factors for pulmonary embolism. If
mothorax, acute asthma, pulmonary congestion related the patient's symptoms are related to chest
to congestive heart failure (CHF), pneumonia, and trauma, the fact that a fall, a blow, or an accident
upper airways obstruction. Most of these conditions re occurred can usually be quickly established.
quire immediate physician evaluation of the acute 4. Do you have any major medical or surgical
problem before physical therapy inlervention. Suba conditions? Cystic fibrosis, chronic obstructive
cute or chronic progression of dyspnea generally pre pulmonary disease (COPD), interstitial lung
sents as increasingly severe dyspnea with exertion over disease, and malignancies are important causes
time. It occurs with emphysema, restrictive lung disor of secondary spontaneous pneumothorax.
ders such as pulmonary fibrosis, chest wall deformi If the therapist strongly suspects pneumothorax or
ties, respiratory muscle dysfunction, occupational lung pulmonary emboli because of the history and physi
diseases, chronic CHF, or large pleural effusions. cal assessment, the patient should be referred for im
Dyspnea may also be related to body position. mediate medical evaluation.
Therefore when evaluating dyspnea, the patient
should be asked if he or she has difficulty breathing
Dyspnea on Exertion
when reclining horizontally. Is it necessary to be
propped up on several pillows to sleep at night (or Dyspnea on exertion is a common complaint of pa
thopnea)? Does she have more difficulty breathing tients with cardiopulmonary dysfunction. Dyspnea
when reclining on one side (trepopnea)? Does he ever during exercise or exertion usually precedes dyspnea
wake up at night short of breath, and need to sit up or at rest (Wasserman, 1982). It most often is a result of
walk around the room to "catch his breath" (paroxys chronic pulmonary disease or CHF. Some causes of
mal nocturnal dyspnea)? dyspnea during exertion or exercise are listed in
Table 7-1.
It is important to establish the amount of activity re
Acute Dyspnea
quired to produce dyspnea. Various scales (Borg, 1982;
The patient that has acute dyspnea requires a rapid and Mahler and Harver, 1990) have been developed to cate
thorough history and physical assessment. The thera gorize the level of dyspnea and impairment present in
pist should ask several important questions to address patients (Figures 7-2, 7-3 and Table 7-2). The patient
the possible causes of acute dyspnea (Mahler, 1987): should be asked about daily activity, and what activities
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7 History 131
TABLE 7-1
MEASUREMENTS THAT
DISORDERS PATHOPHYSIOLOG Y DEVIATE FROM NORMAL
Pulmonary
Airflow limitation Mechanical limitation to ventilation VE maxlMVV, expiratory flow pattern, VDNT;
mismatching of VA/Q, hypoxic V02 max, VEiVo2 VE response to hyperoxia,
stimulation to breathing (A-a)po2
Restrictive Mismatching V A/Q, hypoxic stimulation
to breathing
Chest wall Mechanical limitation to ventilation VE max/MVV, Paco2 V02 max
Pulmonary circulation Rise in physiological dead space as Vo/VT, work-rate-related hypoxemia V02 max,
fraction of VT, exercise hypoxemia VENo2, (a-ET)pco2, Orpulse
Cardiac
*VA-alveolar ventilation; Q---pulmonary blood flow; MVV-max-imum voluntary ventilation; VoIV.-physiologic dead space/tidal
volume ratio; Or- oxygen: V02-02 consumption; (A-a)P02-alveolar-arterial P02 difference; (a-ET)pco2-anerial-end tidal Peo2
difference. (Reprinted with permission from Wasserman K: Dyspnea on exertion: Is it the heart or lungs? lAMA 248: 2039-2043, 1982.
© 1982 American Medical Association.)
produce breathlessness (Constant, 1993). Does the pa cent onset of dyspnea is more characteristic of heart
tient become short of breath climbing a flight of stairs failure than chronic lung disease, which has a longer,
or walking uphill? Is the patient able to walk and talk insidious onset. Acute pulmonary problems such as
simultaneously? Does walking slower affect the indi pneumothorax, atelectasis, pneumonia, and other
vidual's dyspnea? conditions superimposed on chronic lung disease can
In addition, when the patient began to notice an in also explain a recent increase in symptoms.
crease in shortness of breath should be noted. A re Is wheezing present with the dyspnea on exertion?
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132 PART II Cardiopulmonary Assessment
TABLE 7-2
GRADE DEGREE
Reprinted with permission from Brooks SM (Chairman): Task group on surveillance for respiratory hazards in the occupational setting.
Survei Ilance for respiratory hazards, ATS News 12-16, 1982.
o Nothing at all
2 Slight
3 Moderate
4 Somewhat severe
5 Severe
7 Very severe
NO BREATHLESSNESS 10 Maximal
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7 History 133
Has there been an associated weight gain? Does the volume, the patient develops a rapid heart rate and a
patient have a positive smoking history and sputum wide arteriovenous O2 difference (decreased capillary
production? If a positive response is received, these P02) at an inappropriately low work rate. Therefore
suggest that COPD is the primary cause of symptoms the exercising muscles (both skeletal and myocardial)
(Constant, 1993). have increased difficulty getting an adequate oxygen
The basic defect that cardiac diseases produce dur supply to perform the necessary work, which results
ing exertion is a limited cardiac output, primarily in dyspnea, fatigue or pain. The lactic acidosis that
caused by a reduced stroke volume (Wasserman, results from the low oxygen delivery to the muscles
1982). To compensate for the relatively low stroke can be measured by either invasive or noninvasive
Functional Classification
Class I
Patients with cardiac disease but without resulting limitations of physical activity; ordinary physical activity does not
l:ause undue fatigue, palpitation, dyspnea, or anginal pain.
Class II
Patients with cardial: disease resulting in slight limitation of physical activity; they are comfortable at res£. Ordinary
physical activity results ill fatigue. palpitation, dyspnea, or anginal pain.
Class III
Patients with cardiac disease resulting in marked limitation of physical activity; they are comfortable at rest. Less
than ordinary physical activity causes fatigue, palpitation, dyspnea. or anginal pain.
Class IV
Patients with cardiac disease resulting in inability to carry on any physical activity without discomfort; symptoms of
cardiac insufticiency or of the anginal syndrome may be present even at rest. If any physical activity is undertaken,
discomfort increases.
Therapeutic Classification
Class A
Patients with cardiac disease whose physical activity need not be restricted in any way.
Class B
Patients with cardiac disease whose ordinary physical activity need not be restricted but who should be advised
against severe or competitive efforts.
Class C
Patients with cardiac disease whose ordinary activities should be moderately restricted and whose more strenuous
efforts should be discontinued.
Class D
Patients with l:ardiac disease whose ordinary activity should be markedly restricted.
Class E
Patients with cardiac disease who should be at complete rest, confined to bed or chair.
Reprinted with permission from the New York Heart Association (1964). Diseases of the heart and blood vessels; Nomenclature alld crite'
ria for diagnosis. (6th ed.). Boston: Little, Brown.
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134 PART II Cardiopulmonary Assessment
gas-exchange methods during exercise testing. The stenosis, it is probably related to an inadequate car
functional and therapeutic capacity of the patient with diac output during exercise. Patients with tetralogy of
hean disease can be estimated based on the history Fallot and other forms of cyanotic heart disease, ex
and symptoms (see box on p. 133). perience both dyspnea and fatigue during exercise
Dyspnea in cardiac patients is usually related to when the aJterial oxyhemoglobin saturation has fallen
metabolic acidosis-induced hydrogen ion stimulus. appreciatively below the resting level.
Also, increased pressure in the right side of the heart
and pulmonary circulation during exertion may stim
Orthopnea
ulate mechanoreceptors that increase ventilation and
induce dyspnea. Orthopnea is dyspnea brought on in the recumbent
Diseases that involve the lungs or thoracic cage position (Hurst, 1990). The patient may state the need
generally prevent external respiration (ventilation) for two or three pillows under the head to rest at
from keeping pace with internal respiration (in the night. This symptom is commonly associated with
cells) (Wasserman, 1982). In other words, patients CHF but may also be associated with severe chronic
outwalk or outrun their lungs during activities or ex pulmonary disease.
ertion. The primary symptom that limits exercise in
pulmonary patients is dyspnea because of the diffi
Paroxysmal Nocturnal Dyspnea
culty they have eliminating CO2 produced by metab
olism. Some individuals such as those with pul Paroxysmal nocturnal dyspnea (PND) is an impor
monary fibrosis and some with COPD do experience tant type of shortness of breath. This symptom has
a decrease in P02 with exercise. Hence, dyspnea on strong predictive value as a sign of CHF (Hurst, et
exertion in pulmonary patients is usually related to ai, 1990). The patient usually falls asleep in the re
hypoxic or hypercapnic stimuli. cumbent position, and 1 or 2 hours later, awakens
from sleep with acute shortness of breath. The pa
tient sits upright on the side of the bed or goes to an
Dyspnea in Cardiac Patients
open window to breathe "fresh air" to get relief from
The cause of dyspnea in cardiac patients depends on shortness of breath.
whether an associated stiffness of the lungs (fall in The mechanism of PND is the transfer of fluid
compliance) is also present (Szidan and Fishman, from extravascular tissues into the bloodstream (or
1988). Dyspnea is the primary symptom of a decom intravascularly) during sleep (Constant, 1993). The
pensating left ventricle (Marriott, 1993). As the ven intravascular volume of fluid gradually increAses
tricle fails to eject the normal volume of blood, it pro until the compromised left ventricle can no longer
duces chronic pulmonary venous hypertension, manage it. The left atrial pressure rises when the rate
congestion, and pulmonary edema, resulting in stiff or of lymphatic drainage from the lungs is unable to
less compliant lungs. This, along with modest hypox keep up with the increased volume of tluid. The in
emia that augments the respiratory drive, increases creased atrial pressure leads to a sufficiently elevated
ventilation and the work of breathing. Tachypnea is pulmonary capillary pressure to produce interstitial
often seen at rest. Exercise exaggerates the pulmonary edema. Patients who are light sleepers awaken early
congestion and edema, promotes arterial and mixed with dyspnea. Deep sleepers may not awaken until
venous hypoxemia, which also increases the amount they develop alveolar edema.
of dyspnea and tachypnea manifested. Fatigue, result Classic PND cannot usually be eliminated by only
ing from low cardiac output, also affects the respira elevating the trunk without lowering the legs. The pa
tory muscles, further increasing the sensation of tient must pool blood in the extravascular tissues of
breathlessness. the legs to get adequate relief, which usually takes at
Dyspnea in cardiac patients without stiff lungs is least 30 minutes. This is why the patient must sit up
primarily seen during exertion or exercise (Szidan, or stand up, and ambulate.
and Fishman, 1988). In uncomplicated pulmonic The patient should be asked about the amount of
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7 History 135
exercise or work performed during the day before an symptom, if first reported in patients over age 40, is
attack on PND. A true left ventricular failure episode often related to heart failure (Hurst, et aI, 1990). When
of PND is more likely to occur after a day of unusual confilmed that the wheezing is because of heart dis
exertion, which has caused an increased amount of ease, the patient is said to have cardiac asthma.
extravascular fluid to accumulate in the legs. If the Wheezing in cardiac patients is a manifestation of nar
patient is participating in an exercise or rehabilitation rowed airways and thickened bronchial walls as a re
program, the level of exercise may need to be re sult of pulmonary edema (Szidan, and Fishman,
duced to prevent PND. 1988). However, if patients have a history of episodes
of wheezing and dyspnea since childhood, COPD, or
asthma is the likely cause. Other pulmonary condi
Platypnea
tions such as eosinophilic pneumonia, bronchopul
Platypnea is the onset of dyspnea when assuming the monary aspergillosis, allergic granulomatosis, etc.,
sitting position from the supine position (Sharf, can cause wheezing (Miller, 1980). Wheezing must be
1989). This unusual phenomenon is often found in differentiated from stridor, which is commonly caused
patients with basilar pulmonary fibrosis or basilar ar by laryngotracheal narrowing due to tracheostomy
teriovenous malformation. It can be related to the re scar, trauma of intubation, laryngeal paralysis,
distribution of blood flow to the lung bases in the sit epiglottitis, or tumors. Chronic pulmonary patients
ting position with resultant ventilation-perfusion may also develop heart conditions, so it is good to re
mismatching and hypoxemia. member patients that complain of wheezing may have
both cardiac and pulmonary disease.
Trepopnea
COUGH
Trepopnea refers to dyspnea in one lateral position
but not the other (Snider, 1994). It is often produced Cough is a common symptom of pulmonary disease.
by unilateral respiratory system pathology such as The cough mechanism consists of three phases:
lung disease, pleural effusion, or airway obstruction. (1) an inspiratory phase, (2) a compressive phase, and
It also is commonly seen in patients with mitral (3) an expiratory phase (Irwin, 1977).
stenosis (Constant, 1993). Occasionally it may be the There are numerous cough irritant receptors lo
result of a fall in blood pressure in the left lateral de cated on the mucosa of the larynx, trachea, bronchi,
cubitus position. If the patient has ischemic heart dis pleura, and external auditory canal. These receptors
ease, the reduction in coronary perfusion can cause are most sensitive at the glottis and carina, and di
either angina or dyspnea. minish rapidly beyond the fourth generation bronchi.
A cough follows stimulation of these mucosal recep
tors by any of a number of factors including inflam
Functional Dyspnea
mation, sputum, foreign bodies, noxious gases or
Functional dyspnea is defined as shOltness of breath at odors, chemical substances, endobronchial tumors,
rest but not during exertion (Shmf, 1989). It is most and extrabronchial pressure on the trachea or bronchi
commonly seen in young women who complain of the (Sharf, 1989).
need to take a deep breath or to sigh and interpret this A productive cough is beneficial for clearing the
sensation as shortness of breath. The physical exami airways of sputum and foreign material, and gener
nation and pulmonary function tests are negative. Re ally should not be inhibited. However, a dry, hacking
assurance is usually all that is necessary. cough is usually of no value and can have a self
perpetuating irritant effect on the respiratory mucosa.
A dry cough may be the initial symptom of certain
WHEEZING
interstitial lung diseases such as allergic alveoli tis,
Patients that complain of wheezing associated with sarcoidosis, and pulmonary fibrosis. Some causes and
dyspnea may have pulmonary or cardiac disease. This characteristics of coughs are listed in Table 7-3.
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136 PART II Cardiopulmonary Assessment
TABLE 7-3
CAUSE CHARACTERISTICS
Tracheobronchitis Cough associated with sore throat, running nose, and eyes
Lobar pneumonia Cough often preceded by symptoms of upper respiratory infection; cough dry,
painful at first; later becomes productive
Bronchopneumonia Usually begins as acute bronchitis; dry or productive cough
Mycoplasma and viral pneumonia Paroxysmal cough, productive of mucoid or blood-stained sputum associated
with influenza-like syndrome
Exacerbation of chronic bronchitis Cough productive of mucoid sputum becomes purulent
Bronchitis Cough productive of sputum on most days for more than 3 consecutive months
and for more than 2 successive years; sputum mucoid until acute exacerbation,
when it becomes mucopurulent
Bronchiectasis Cough copious, foul, purulent, often since childhood; forms layer on standing
Tuberculosis or fungus Persistent cough for weeks to months often with blood-tingling of sputum
J nterstitial fibrosis and infiltrations Cough nonproductive, persistent, depends on etiologic factors
Smoking Cough usually associated with injected pharynx; persistent, most marked
in morning, usually only slightly productive unless succeeded by chronic
bronchitis
Tumors
Bronchogenic carcinoma Nonproductive to productive cough for weeks to months; recurrent small
hemoptysis common
Alveolar cell carcinoma Cough similar to bronchogenic carcinoma, except in occasional instance when
large quantities of watery, mucoid sputum are produced
Benign tumors in airways Cough nonproductive, occasionally hemoptysis
Mediastinal tumors Cough, often with breathlessness, caused by compression of trachea and bronchi
Aortic aneurysm Brassy cough
Foreign body
Immediate, while still in upper airway Cough associated with progressive evidence of asphyxiation
Later, when lodged in lower airway Nonproductive cough, persistent, associated with localizing wheeze
Cardiovascular
Left venuicular failure Cough intensifies while supine along with aggravation of dyspnea
Pulmonary infarction Cough associated with hemoptysis, usually with pleural effusion
Reprinted with permission from Szidon J, Fishman A: Approach to the pulmonary patient with respiratory signs and symptoms. In Fishman
A, editor: Pulmol1{//y diseases alld disorders. New York, 1988, McGraw-Hill.
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7 History 137
Cough may be the only presenting symptom of deep breathing suggests asthma or interstitial lung
asthma. In asthmatics, cough is precipitated by inhal disease. Allergens or irritant fumes at home or at
ing cold air or exercise, and is dry. Cough can precip work may be a cause of cough. Postviral cough may
itate an asthma attack in sensitive patients and is be present for weeks following a viral illness.
known as cough-induced bronchospasm. Some medications can elicit coughing. Beta
It is important to determine the length of time blockers prescribed to treat hypertension, migraine
cough has been present (Sharf, 1989). The most com headaches, cardiovascular disease (CVD), or glau
mon cause of an acute cough is a viral respiratory in coma may precipitate asthma. Many drugs, including
fection, which generally resolves within a few days chemotherapeutic agents, can cause interstitial lung
or 2 to 3 weeks. Exposure to noxious gases also pre disease and coughing.
cipitates acute coughing. Cough and wheezing may result from COPD,
A cough that has persisted for more than 3 weeks asthma, or early left heart failure. Early left heart fail
can be termed chronic (Snider, 1994). The most com ure predisposes the patient to respiratory infections
mon cause of chronic cough is chronic bronchitis, and may be responsible for chronic bronchitis.
and is present in up to 30% of cigarette smokers. The
next most common cause is the postnasal discharge
Cough Complications
syndrome. Patients describe a sensation of secretions
dripping from the back of the nose into the throat, One of the more common complications of cough is
prompting throat clearing or coughing. syncope. Tussive or cough-induced syncope, which is
Various cardiac conditions may stimulate receptors more common in men than women, can be recognized
in the bronchi and provoke coughing (Goldberger, through accurate history taking (Miller, 1980). It is
1990). Because the bronchial veins empty into the typically reported by middle-age men who "smoke
pulmonary veins (leading to the left side of the heart), hard, eat hard, drink hard, and cough hard." They ex
systemic veins, and the superior vena cava (leading to perience fainting or near-fainting following cough
the right side of the heart), venous congestion and paroxysms. The cause is obscure but may be related to
coughing may occur with either right- or left-side vagal-induced cardiac slowing or vasodilatation, or
CHF. It is more common, however, with left-sided high intrathoracic pressures that impair venous return,
CHF. The onset of a cough in a patient with paroxys decrease cardiac output, increase intracranial pressure,
mal tachycardia or acute myocardial infarction (MI) is and result in a reduced cerebral blood flow. Cough
often an early symptom of acute left-side heart failure. syncope is often resolved by smoking cessation.
Coughing may be caused by other cardiovascular Complications of cough include headache, back
conditions such as a large left atrium displacing the pain, muscular tears, hematomas, rib fractures (along
left main-stem bronchus upward, aortic aneurysms the posterior axillary line), occasionally vertebral
placing pressure on the bronchi, or a double aortic compression fractures (in osteopenic patients), urinary
arch compressing the trachea. incontinence (UI) (in women), and inguinal hernias
A specific diagnosis can be made in 80% of cases (in men) may occur (Braman and Corrao, 1987).
of chronic cough by an appropriate history alone
(Stulberg, j 985). Determining the precipitating
CHEST PAIN
causes or the time of onset points the clinician to a
probable diagnosis. For example, does the patient Taking an accurate history is crucial to the proper
cough primarily at night? If so, it points to heart fail evaluation of chest pain (Snider, j 994). Although the
ure, esophageal problems, bronchiectasis or asthma definitive cause of chest pain cannot be fully estab
as the potential cause. An early morning cough is lished without diagnostic medical tests, it is usually
more common in bronchitis and individuals with possible to determine whether the pain originates in
postnasal drip. Cough following meals suggests the pleura, chest wall, or thoracic organs by means of
esophageal disease. Cough precipitated by exertion or careful history taking.
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138 PART II Cardiopulmonary Assessment
Chest pain can be divided into two basic types: palpated at the wrist. If a patient opens and
chest wall pain and visceral pain (George, 1990). The closes a fist, pain will gradually appear and es
first arises from involved thoracic cage structures and calate in the forearm. The causal mechanism of
tends to be superficial and well-localized. The latter this pain is the same as that of myocardial pain:
arises from the heart, pericardium, aorta, medi continuing muscular contraction in the absence
astinum, bronchi, or esophagus. It is described as of an adequate oxygen supply. This type of
deep and difficult to localize. pain requires several contractions of the my
ocardium to reach its maximal intensity. In
other words, there is a characteristic buildup or
Pleuritic
escalation of angina pain.
Pleuritic chest pain originates from the parietal pleura 2. Can you point to the area of pain with one
or endothoracic fascia, but not the visceral pleura, finger? Anginal pain is characteristically
which has no pain receptors. The patient can usually demonstrated by patients using their entire
identify it as being close to the thoracic cage (Szidan, hand or closed fist against the anterior chest
Fishman, 1988). Pleuritic chest pain worsens sharply wall. It is described as a sign of angina, because
with inspiration as the inflamed parietal pleura is it is so typical (Marriott, 1993). By contrast,
stretched with chest wall motion. Deep breathing, any pain that can be localized by pointing with
coughing, or laughing are extremely painful, requir a fingertip is unlikely to be angina.
ing the patient to apply pressure over the involved 3. Is the pain deep inside your chest or does it
area to control the pain. seem as though it is close to the surface?
Pleuritic chest pain is ordinarily found in patients Anginal pain is visceral pain that may be re
that have other signs of respiratory illness, such as ferred superficially but always has a deep inter
cough, fever, chills, malaise. Inflammation of the di nal component to it.
aphragmatic pleura produces ipsilateral shoulder pain Myocardial ischemia may be completely painless
by way of the phrenic nerve (Miller, 1980). (silent ischemia). Angina may in fact not be painful
The onset of pleuritic chest pain varies according but rather described as discomfort, pressure, squeez
to its cause (Snider, 1994). Sudden severe pleuritic ing, a tight band, heaviness, burning, indigestion. It
chest pain suggest a spontaneous pneumothorax, pul usually is located substernally and radiates into one
monary embolism, or infarct. Pulmonary embolism is or both arms, neck, jaw, or back.
usually accompanied by sudden dyspnea, hemoptysis, Angina is not limited only to patients with CAD
tachycardia, cyanosis, hypotension, anxiety, and agi (Marriott, 1993). Individuals that have normal coro
tation (Marriott, 1993). nary arteries but an insufficient oxygen supply for a
given cardiac workload can also experience angina.
These include individuals with anemia, hypertension,
Cardiac
tachycardia, and thyrotoxicosis. Hypertrophic and di
There are three cardinal features that are characteris lated cardiomyopathy can produce typical angina
tic of cardiac chest pain. The patient should be asked pain, although the latter tends to be intermittent, usu
the following questions (Marriott, 1993): ally occurring with episodes of CHF. Aortic valve
I. Does the pain have maximal intensity from disease can cause angina as a result of impairment of
the onset or does it build up for several sec adequate coronary artery blood tlow.
on ds? Ischemic cardiac pain or angina is Angina is usually precipitated by exertion such as
caused by the myocardium contracting in the walking uphill, against the wind, or in cold weather
absence of an adequate oxygen supply. The (Marriott, 1993). It also is more likely to be brought
same type of pain can be produced by placing a on after a meal or by emotional stress. The rapid
blood pressure cuff around the upper arm and resolution of chest pain by rest or sublingual nitro
inflating it until the brachial pulse is no longer glycerin strongly suggests a cardiac origin. The pain
Copyrighted Material
7 History 139
produced by MI is longer, persisting more than 20 suggest an esophageal origin (Snider, 1994). Also,
minutes; occurs at rest; and is accompanied by nau diffuse esophageal spasm is often associated with
sea, diaphoresis, hypotension, and dyspnea. pain on swallowing (odynophagia), dysphagia, and
regurgitation of stomach contents. Swallowing hot or
cold liquids, or emotional stress tend to precipitate
Pulmonary Hypertension
this type of chest pain.
Chest pain related to pulmonary hypertension may
mimic angina pectoris. It is usually found in patients
Chest Wall
with mitral stenosis or Eisenmenger's syndrome (pul
monary hypertension related to an interventricular Chest wall pain is the most common type of chest
septal defect, patent ductus arteriosus, or atrial septal pain. Clues in the patient's history to this type of pain
defect). This type of chest pain is usually absent at include intermittent occurrence, variable intensity,
rest, occurs during exertion, and is invariably associ and local tenderness (Miller, 1980). Because it is
ated with dyspnea (Hurst, et ai, 1990). It is believed often located on the anterior chest wall, many pa
to be because of dilation of the pulmonary artery or tients believe it is heart pain. However, an important
right ventricular ischemia. The pain is not relieved by differentiation from cardiac pain is that it does not
nitrates. Primary pulmonary hypertension may be ac occur during but rather following exertion. It may
companied by syncope and Raynaud's phenomenon worsen with inspiration, but its association with trunk
(Sharf, 1989). motions (flexion, extension, rotation) distinguish it
from pleuritic chest pain.
Localized anterior chest pain as a result of costo
Pericardial
chondritis of the second to fourth costosternal articu
Pericardial chest pain is also midline, but because of its lations (Tietze's syndrome) is described as tender to
anatomical relationship with the mediastinal pleura, it touch (George, 1990). A complaint of rib tenderness,
has features that suggest pleural involvement (Snider, together with a history of trauma, fall, long-term
1994). Deep breathing, coughing, swallowing, move steroid use, coughing, or upper extremity exertion,
ment and lying down may make it worse. If the central suggests rib fracture.
tendon of the diaphragm is involved, the pain may be Degenerative disk disease and arthritis of the cervi
referred to the left shoulder or scapular area (Marriott, cal or thoracic spine, thoracic outlet syndrome,
1993). The patient may report that each hemibeat af spondylitis, fibromyalgia, kyphoscoliosis, and herpes
fects the pain. Sitting up and leaning forward, or lying zoster can all produce chest wall pain (Epstein, Ger
on the right side often relieves the pain. ber, and Borer, 1979; Miller, 1980; Pellegrino, 1990;
Snider, 1994; Wise, Semble, and Dalton, 1992). Pri
mary lung cancer that invades the adjoining chest
Esophageal
wall, ribs, or spine produces severe persistent local
Diffuse esophageal spasm or esophageal colic is a ized pain (Snider, 1994). Pancoast's syndrome (supe
common cause of chest pain. It is often confused with rior sulcus tumor), in which a primary lung tumor lo
cardiac pain because it is located substernally, has a cated in the extreme apex of the lung invades the
squeezing or aching quality, and may radiate into one brachial plexus and produces pain in the shoulder,
or both arms (George, 1990). Furthermore, diffuse scapular region, or medial aspect of the arm and hand.
esophageal spasm may be relieved by sublingual ni Chest wall pain may rarely be caused by thrombo
troglycerin as a result of its generalized function as a sis of a superficial vein on the chest wall (Mondor's
smooth muscle relaxant. disease). It is a self-limiting condition of unknown
Pain that radiates through the chest to the back, origin and can last several weeks (Snider, 1994). The
pain that decreases by a change in position from only physical finding is a subcutaneous cord that can
supine to upright, or relief by ingesting antacids, all be palpated along the lateral chest wall.
Copyrighted Material
140 PART II Cardiopulmonary Assessment
Copyrighted Material
7 History 141
when the total blood protein falls below 5 gmllOO ml nations of obstmctive and restrictive lung disease (e.g.,
(hypoproteinemia). Other causes of pedal edema in silicosis). Constmction workers, shipyard workers,
clude liver disease, kidney disease, and anemia. pipefitters, and other industJial workers exposed to as
Edema of one leg is ordinarily because of local fac bestos are at increased risk for developing a restrictive
tors such as thrombophlebitis or varicose veins. lung disease such as asbestosis (Varkey, 1983). Benign
pleural plaques may be found on the diaphragmatic
pleura and bilaterally between the sixth and tenth ribs
HOARSENESS
on the anterolateral or posterolateral chest wall. Pro
Hoarseness, abnormal vocal cord motion during gressive pleural thickening rarely occurs. These indi
phonation, is a symptom of laryngeal dysfunction viduals have an increased incidence of malignant neo
(Miller, 1980). It is usually associated with upper res plastic diseases such as bronchogenic carcinoma and
piratory tract infections or allergies, and resolves in 1 malignant mesothelioma.
to 2 weeks (Sharf, 1989). Trauma following intuba Coal workers are exposed to coal mine dust.
tion, laryngeal polyps, or tumors are other common About 10% have simple pneumoconiosis, whereas a
causes of hoarseness. However, this symptom is also smaller proportion develop the complicated form
related to cardiopulmonary conditions. Because the progressive massive pulmonary fibrosis (Brandstetter
recurrent laryngeal nerves pass through the upper and Sprince, 1982).
thorax, intrathoracic pathology that involves one of A history of paroxysmal coughing, chest tightness,
these nerves can cause unilateral vocal cord paralysis, or dyspnea that is worse during the week but remits
resulting in hoarseness (Shalf, 1989). These include on weekends strongly suggests occupational asthma
lung or mediastinal tumors, granulomatous disease, (Brandstetter, and Sprince, 1982). This condition is
enlarged mediastinal lymph nodes, and pericardial or difficult to diagnose because symptoms often occur
mediastinal adhesions. several hours after exposure to the provoking agent.
Several cardiovascular conditions can produce Causal agents include grain dusts, wood dusts, forma
hoarseness, because the left recurrent laryngeal nerve lin, enzyme detergents, ethanolamines (in spray
loops under the arch of the aorta and above the pul paints and soldering flux), nickel and hard metals
monary artery as it returns to the neck (Hurst, et ai, (tungsten carbide). Workers exposed to cotton flax
1990). Therefore an aneurysm of the arch of the and hemp dusts may develop byssinosis, an obstmc
aorta, a dilated pulmonary artery or atrium resulting tive lung disease. In the early stages, it is reversible,
from an atrial septal defect, or mitral stenosis can but long-term exposure over a number of years
cause hoarseness (Goldberger, 1990). causes chronic irreversible obstructive lung disease.
Hence, if patients manifest hoarseness, it is neces A history of fever, cough, shortness of breath,
sary to inquire about the length of time it has been and recurrent pneumonias in farmers in the north
present, the patient's smoking history, and any his ern United States suggests farmer's lung (Brand
tory of cardiac or pulmonary diseases. stetter, and Sprince, 1982). This is the most com
m o n h y p e r s e n s i t i v e pneumonitis, c a u s e d b y
inhaling fungal agents such a s thermophilic actino
OCCUPATIONAL HISTORY
mycetes. Long-term exposure can lead to pul
Taking an occupational history is particularly impor monary fibrosis. There are numerous occupations
tant for pulmonary patients who arrive for physical that expose workers to etiologic factors that cause
therapy with little or no accompanying medical infor hypersensitive pneumonitis.
mation. The internal surface of the lung measures 50 to
100 m] and is in constant contact with the environment
SMOKING HISTORY
(Miller, 1980). Jobs that involve exposure to silica or
silicates (e.g., miners, sandblasters, foundry workers, The patient should be asked their tobacco-smoking
stone cutters, brick layers, or quarry workers) or other history (Snider, 1994). The number of pack-years of
inorganic substances place workers at risk for combi cigarettes smoked may be calculated (average number
Copyrighted Material
142 PART II Cardiopulmonary Assessment
PRIOR TREATMENT Birdwell, B., Herbers, J., & Kroenke, K. (1 993). Eva lua ting chest
pain: the patient's presen tation style alte rs the phy si c ia n
s dia g
'
It is important to deterrnine what treatment(s) the pa n o s ti c a p p r oach . Arch ives of In/ernal Med i c ine, 153,
tient has received for his or her condition. Specifically, 1991-1995.
has the patient ever received physical therapy for this Borg, G. (1982). Psyc ho physic al bases of perce i ve d exertion. Merl
icine and Science in SPOrlS and t:rercise, 1 4, 377-381.
or any other condition? What type of treatments were
Braman, S., Corrao, W. (1 987) . Cough: differen/ial diagnosis and
done? Were they helpful in improving or resolving the
/realinel1l. Clinical Ches/ Medicine 8(2), 1 77-188.
condition? In this way we determine what treatment Brandsteller, R .. Sp rince, N. (1982). Occ u p at i on al lun g disease.
modalities have been used, which of these the patient Medical Times, June, 56-63.
believes may have merit, and those with which the pa Constant, J. (1993). The evolving checklist in history-taking. In
careful history taking. This information enables ther Hurst, 1., et al. (1990). The h ist ory: past events and symptoms re
lated to cardiovascular disease. In Hurst, J. (Ed.). The heall.
apists to select the most appropriate evaluation and
N ew York: McGraw-Hili.
treatment techniques. When properly performed, ac Mahler, D. (1987). Dyspnea: diagnosis and management. Clin ics ill
curate h istory taking gains the patient's confidence Ches/ Medicine. 8(2), 215-230.
and cooperation, and provides the basis for a good Mahler, D., & Harvel', A. (1990). Clinical measureme nt s of dysp
nea. In Mah l e r, D. (Ed.). Dysp/1ea. Mount Kisco, NY: Futura.
patient-therapist relationship.
Marriol!, H. (1993). Taking the history. In Marriol!, H. Bedside
cardiac diagnosis. Ph i ladelphia: JB Lippincott.
Copyrighted Material
7 History 143
Miller, D. (1980). The medical history. [n Sackner, M. (Ed.). Szidan, P., & Fishman, A. (1988). Approach to the pulmonary pa
Diagnostic techniques in pulmonary disease. New York: tient with respiratory signs and symptoms. [n Fishman, A.
Marcel Dekker. (Ed.). Pulmonary diseases and disorders. (2nd ed.). New York:
Pellegrino, M. ( 1990). Atypical chest pain as an initial presentation McGraw-HilI.
of primary fibromyalgia. Archives of Physical Medicine and Varkey, B., (1983). Asbestos exposure: An update on pleuropul
Rehabilitation 71, 526-528. monary hazards. Postgraduate Medicine, 74(4),93-103.
Sharf, S. (1989). History and physical examination. [n Baum, G., Wasserman, K., (1982). Dyspnea on exertion: is it the heart or the
& Wolinski, E. (Eds.). Textbook of pulmonary diseases. (4th lungs? Journal of the American Medical Association, 248,
ed.). Boston: Lillie, Brown. 2039-2043.
Snider, G. (1994). History and physical examination. [n Baum, G., Wise, C., Semble, E., & Dalton, C. (1992). Musculoskeletal
& Wolinski, E. (Eds.), Textbook of pulmonary diseases. (5th chest wall syndromes in patients with noncardiac chest pain:
ed.). Little, Brown. A study of 100 patients. Archives of Physical Medicine and
SlUlberg, M. (1985). Evaluating and treating intractable cough R eha bilitation, 73, 147-149.
Medical Staff Conference, University of California, San Fran
cisco. West 1 Med, 143,223-228.
Copyrighted Material
Pulmonary Function Tests
Donna Frownfelter
145
Copyrighted Material
146 PART II Cardiopulmonary Assessment
approximately I SO mL anat(}mic dead space. A nor functioning alveoli. This causes increased work of
mal tidal volume (TV), the breath normally taken, breathing and may result in patient fatigue. Neurolog
needs to be large enough to reach the alveoli well ical and neuromuscular weakness may result in an in
past the anatomic dead space. In a normal adult, the ability to take a normal TV. Similarly, surgical proce
TV is generally 450 to 600 mL. The anatomic dead dures or p a i n f r o m fractured r i b s c a n also
space would thus represent about one third TV vol compromise a patient's ability to take a breath. As
ume. The rest of the breath would reach the alveoli the TV drops a large percentage of the breath is
and be considered "alveolar ventilation." With many anatomic dead space. This results in increased work
neurologically impaired patients who have a limited of breathing for the patient and may ultimately result
TV, it is important to note that little alveolar ventila in respiratory failure if the patient is unable to pro
tion may be taking place when the patient is breath vide alveolar ventilation.
ing in a rapid and shallow pattern. For example, if a
p a t i e nt's TV w a s 200 mL, IS O mL w o u l d be
lUNG VOLUMES
anatomic dead space and only SO mL of each breath
would be alveolar ventilation. The lung has four volumes, TV, inspiratory reserve
There are many diseases or conditions that can alter volume (IRV), expiratory reserve volume (ERV), and
the volume of dead space that needs to be ventilated. In residual volume (RV) (Figure 8-1).
some cases the dead space decreases, such as in a pneu •
TV is the normal breath.
monectomy, where it is physically removed, or in •
IRV is the maximal amount of air that can be in
asthma, where bronchospasm may narrow the airways. haled from the end of a normal inspiration.
In other conditions such as pulmonary embolus, dead •
ERV is the maximal amount of air that can be ex
space increases when ventilated areas of lung cease to pired after a normal exhalation.
be perfused. The alveoli continue to receive fresh gas, •
RV is the volume of gas that remains in the lungs
but there is no blood available for gas exchange. This at the end of a maximum expiration.
type of dead space is known as physiologic dead space. Changes in RV can help in the diagnosis of certain
When dead space is increased, a larger percentage medical conditions. An increase in RV means that
of the tidal volume is ventilating the dead space, even with maximum effort, the patient cannot exhale
leaving a smaller percentage for alveolar ventilation. excess air from the lungs. This results in hyperin
The patient must work harder to get enough air to the flated lungs and indicates that certain changes have
---I
\tj
( C,\.'--
'- '--
FIGURE 8-1
A spirogram (pulmonary function testing).
Copyrighted Material
8 Pulmonary Function Tests 147
occurred in the pulmonary tissue, which in time may FRC is the volume of air remaining in the lungs at
cause mechanical changes in the chest wall (e.g., in the resting expiratory level. It contains the ERV and
creased AP diameter, flattened diaphragms). These the RV.
changes may be reversible in patients with partial The FRC prevents large fluctuations in Pa02 with
bronchial obstruction, such as young asthmatics, or each breath. An increase in FRC represents hyperin
irreversible, as in patients with advanced emphy flation of the lungs. It causes the thorax to be larger
sema. Restrictive lung disease can cause a decrease in than normal, which results in muscular inefficiency
residual volume, as can cancer of the lung, microat and some mechanical disadvantage. Patients on me
electasis, or musculoskeletal impairment. (Smith and chanical ventilators may increase their FRC with pos
Dickson, 1994). itive pressure and by additional modes such as posi
tive end expiratory (PEEP), or BiPap. Spontaneously
breathing patients can also be on continuous positive
LUNG CAPACITIES
airway pressure (CPAP), which keeps the lungs at a
A lung capacity is two or more volumes added to positive airway pressure to improve oxygenation.
gether (Figure 8-1). The capacities include total lung
capacity (TLC), vital capacity (VC), inspiratory ca
AIR FLOW MEASUREMENTS
pacity (IC) and functional residual capacity (FRC).
Forced Expiration
TLC is the amount of gas the lung contains at the
end of a maximum inspiration. It is made up of all four When patients peIform a VC maneuver, it can either
lung volumes. An increased TLC is seen with hyperin be slow or fast. During exhalation, the amount of air
flation such as emphysema. A decrease in TLC may be exhaled over time can be measured. In a slow VC a
seen in restlictive lung disease such as pulmonary fi patient with emphysema can take a great deal of time
brosis, atelectasis, neoplasms, pleural effusions, and to empty his lungs. In a forced VC a normal individ
hemothorax, as well as in restrictive musculoskeletal ual can exhale 75% of the VC in the first second of
problems such as spinal cord injury, kyphoscoliosis, or exhalation (FEV I). Patients with emphysema often
as secondary to morbid obesity or pregnancy. have greatly decreased VCs, only 40% of which are
VC is the maximum amount of gas that can be ex predicted.
pelled from the lungs by forceful effort following a
maximum inspiration. It contains the IRV, TV, ERV.
Flow Volume Curve
A decrease in VC can occur as a result of absolute re
duction in distensible lung tissue. This is seen in The flow volume curve is helpful in diagnosing lung
pneumonectomy, atelectasis, pneumonia, pulmonary disease, since it is independent of effort. The curve in
congestion, occlusion of a major bronchus by a tumor Figure 8-2 demonstrates that flow rises to a high
or foreign object, or restrictive lung disease. value and then declines over most of expiration
A decrease in VC may also be seen without pri (Rahn, et ai, 1946). In restrictive lung disease, the
mary lung disease or airway obstruction. In neuro maximum flow rate is reduced, as is the total volume
muscular or musculoskeletal dysfunction, VC can be exhaled. In obstructive lung disease, the flow rate is
compromised (Guillain-Barre, spinal cord injury, low in relation to lung volume, and a scooped-out ap
drug overdose, motor vehicle accident with fractured pearance is often seen (see Figure 8-2).
ribs, severe scoliosis, and kyphoscoliosis). Restrictive Another diagnostic test that uses forced expiration
contributing factors such as morbid obesity, preg is the flow volume loop. It is a graphic analysis of the
nancy, enlarged heart, and pulmonary effusion may flow generated during a forced expiratory volume
involve the limitation of expansion of the lungs. maneuver followed by a forced inspiratory volume
IC is the maximal amount of air that can be in maneuver (Figure 8-3). This graph offers a pictorial
spired from the resting expiratory level. It contains representation of data from many individual tests
the IRV and the TV. (e.g., peak inspiratory and expiratory flow rates,
Copyrighted Material
148 PART II Cardiopulmonary Assessment
Z NORMAL
o
wi=
a:- U
a.. Q)
II)
:> X '
:;>o w -.J OBSTRUCTIVE
o
-.J<..9
u...Z
0::
=:J
o
10 9 8 7 6 5 4 3 2 o
LUNG VOLUME (Liters)
FlliURE 8-2
Comparison of tlow volume curves in the normal patient and in the patient with obstructive and
restrictive lung disease.
-r---- /\,.----;;;50%
+5 PFexp
/ \ j EXPIRATION
U
Q)
II)
,
i 01
o
Ie F; \
-.J
u...
INSPIRATION
-5 PF insp
J __ _
OBSTRUCTION
o 2 4 6
VOLUME (Liters)
FIGURE 8-3
Compatison of flow volume loops in the normal patient and in the patient with obstructive
lung disease.
Copyrighted Material
8 Pulmonary Function Tests 149
FVC, and FEV). The shape of the graph may also be in N2 concentration. This high N2 concentration re
helpful in diagnosing disease, again seeing a more flects closure of airways at the base of the lungs and
scooped-out appearance with obstructive disease. expiration of gas from the upper lung zones, because
in the single breath of 100% oxygen, less oxygen was
initially directed to this area.
CLOSING VOLUME AND AIRWAY CLOSURE
Closing volume is the lung volume at which the
The assessment of closing volume is used to help di inflection of Phase IV, the marked increase in N2
agnose small airway disease. A test called the single concentration after the plateau, is observed. Closing
breath nitrogen (N2) washout is used for assessing capacity refers to closing volume and RV. The same
closing volume and closing capacity of the small air characteristic tracing of the single breath nitrogen
ways. In this test, the patient takes a single VC breath washout test can be obtained with an inhalation of a
of 100% oxygen. During complete exhalation, the N2 bolus of tracer gas (e.g., argon, helium, xenon-133).
concentration can be measured. The characteristic The closing volume is 10% of the vital capacity in
tracing of N2 concentration can be measured. The young, healthy individuals. It increases with age and
characteristic tracing of N2 concentration vs. lung vol is 40% of the vital capacity at age 65. Closing vol
ume reflects sequential emptying of differentially ven ume is used as an aid in the diagnosis of small airway
tilated lung units, resulting in different expiratory N2 disease and as a means of evaluating treatment or
concentrations. Four phases can be identified (Figure drug response.
8-4). Phase I contains pure dead space and virtually
none of the potential N2 from the RV. Phase Il is asso
MAXIMAL VOLUNTARY VENTILATION
ciated with an increasing N2 concentration of a mix
ture of gas from the dead space and alveoli. The Maximal voluntary ventilation measures the maximal
plateau in N2 concentration observed in Phase III re breathing capacity of the patient. It reflects strengths
flects pure alveolar gas emanating from the bases and and endurance of the respiratory muscles. The patient
middle lung zones. Phase IV occurs toward the end of is asked to pant for 15 seconds into the spirometer tub
expiration and is characterized by an abrupt increase ing. This is often examined preoperatively with the
I
z
DEPENDENT AIRWAY BEGIN
I
o
(f)- TO CLOSE ------, I
«f
(9«
0::: I
f-f
o:::Z
WW
I
ZU
-z
I
o
U I
I
TLC VOLUME (Liters) RV o
Closing
Vol.
HCVl----!
FIGURE 8-4
The single breath nitrogen washout test to assess airway closure.
Copyrighted Material
150 PART II Cardiopulmonary Assessment
other results to determine a patient's prognosis for suc ration). An obstructive component generally relates to
cess after surgery, such as his or her ability to cough, problems in exhalation air flows and characteristic
to take deep breaths, and to enhance airway clearance. patterns of obstruction, such as in the first second of
expiration FEY I measurement). Patients do not often
have only one primary disease process but many times
DIAGNOSIS OF RESTRICTIVE
have overlapping lung conditions (Clausen, 1984). A
AND OBSTRUCTIVE LUNG DISEASE
diagnosis may read: PFTs consistent with moderate
Physicians use the results of pulmonary function tests emphysema with bronchospastic component; good re
to diagnose lung disease or characteristic components sponse to bronchodilators. A patient with an abnormal
of lung disease, such as bronchospasm. A restrictive PFr is given a bronchodilator and retested. If there is
component describes conditions that limit the amount a 15% to 20% increase in the PFr after bronchodila
of volume coming into the lungs (restriction to inspi tors are administered, they will be a recommended
IRV
IC i
i
VC
IRV
TLC
VC
TV IC
C
TV TI C
ERV
ERV
FRC I
RV
l
F
FRC
RV
FIGURE 8-5
Examples of proportional changes of lung volumes and capacities characteristic of
obstructive and restrictive lung diseases.
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8 Pulmonary Function Tests 151
part of the patients' medications. However, some pa a loss of intrapleural negative pressure. In older indi
tients are given a trial of bronchodilators, even if there viduals, therefore, airway closure occurs at higher lung
is not such a dramatic response on PFfs). volumes. For example, closure has been reported to
A pictorial demonstration of the differences in ob occur at the age of 65 in the upright lung during nor
structive and restrictive lung disease is shown in Fig mal breathing. In the supine position, where FRC is re
ure 8-5. Disease has a marked effect on pulmonary duced, closure occurs at a significantly younger age
function, yet TV usually remains 10% of total lung (about age 44). In addition to the often compounding
capacity until the disease is relatively severe. Physio effect of age, the lung volume at which airway closure
logic pulmonary reserves in both disease processes occurs increases with chronic smoking and lung dis
are limited and generally affect a patient's response ease, and is changed with the alterations in body posi
to exercise. Exercise will be limited by the ventila tion (Ben)" Pai, and Fairshter, 1990; Zadai, 1985).
tory status ratlier than by a cardiac end point. As ob
structive lung disease progresses, TLC, FRC, and RV
SUMMARY
are markedly increased. In severe COPD, the in
creased FRC can compromise the Vc. More energy Pulmonary functions change as a patient's condition
is expended to breathe compared with that expended gets better or worse (Emery et ai, 1991; Emerson,
by a normal individual. This effect can be dispropor Lukens, Effron, 1994). There are normal declines in
tionally increased with minimal amounts of activity. volumes and flows with aging as well as disease
In restrictive lung disease, restriction of the chest processes. Basic bedside spirometry is often done to as
wall or lung tissue can produce a decrease in TLC. A sess the patient's breathing mechanical ability. For ex
VC of 80% or less of predicted values for a patient is ample, in a patient with Guillain Ban'e, as breathing be
considered a diagnostic feature. A residual decline in comes labored, the VC is monitored to determine
FRC potentiates airway closure. whether a ventilator is needed. On the other hand, a pa
The phenomenon of closing volume in the lungs is tient with obstructed airways, such as the patient with
particularly significant to physical therapists (PTs) cystic fibrosis, the pulmonary function tests will im
who prescribe breathing exercises and body position prove (Versteegh, et ai, 1986). In patients with spinal
ing, and can thereby alter pulmonary mechanics and cord injury or neuromuscular weakness, as their
gas exchange. These treatment interventions may strength improves, their vital capacity increases. How
have a pronounced effect on the lung volumes and ever, because of the lack of abdominal muscles, the
airway closure (Dean, 1985). At low lung volumes flows may be reduced.
(e.g., breathing at FRC, Trendelenberg position, and
in lung disease) intrapleural pressures are generally
REVIEW QUESTIONS
less negative and the pressure of dependent lung re
gions may equal or exceed atmospheric pressure. In 1. What effect will an obstructive component have on
trapleural pressure is less negative because the lungs exercise performance? What effect will a restric
are less expanded and elastic recoil is decreased. As a tive component have on excercise peliormance?
result, airway closure is potentiated. In young indi 2. Why is it important to compare the patient's pre
viduals, closure is evident at RV; however, in older dicted values with the actual observed values in a
individuals, closure is observed at higher lung vol pulmonary function test?
umes, such as at FRC. Premature closure of the small 3. What response should you see to determine if
airways results in uneven ventilation and impaired bronchodilators have a positive effect on pul
gas exchange with a given lung unit. Airway closure monary function?
occurs more readily in chronic smokers and in pa 4. How can pulmonary function tests be used to as
tients with lung disease. sess patient improvement or decline?
Aging has a significant effect on airway closure. 5. How valuable are pulmonary function tests if pa
With aging, a loss of pulmonary elastic recoil results in tients do not give maximal effort?
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152 PART II Cardiopulmonary Assessment
References
Rahn, H" et aL (1946), The prcS'urc·volume of the thorax
Berry, R., Paj, U. & Fairshter, R, (1990). Effect of age on changes lung, American Journal of Physiology, 146, J 61.
in !low rates and airway conductance after a deep breath, Jour Smith, R.M., & Dickson, R,A. (1994), Changes in residual volume
nal of Applied Physiology. 68, 635-{543. relative to vital capacity and total lung capacity after arthrode
Cherniak, R,M, (! 992J, Evaluation of respiratory function in health sis of spine in patients who have idiopathic scoliosis. BOI1<'
and Dis Man, (7),505-76, and Join! Surgo)' 76 (I), I
Clausen, J.L. (1984). Pulmonary function tcstlng; guidelines and Ven;tcegh, F.G,A., et a!. (1986), Relationship between pulmonary
controversies, London: Grune and Stratton, function, O2 saturation during sleep and exercise with cystic
Crapo, R.O, (1 Pulmonary function testing, New England brosis. Advanced Cmdiology, lSI-ISS, 1986,
Joumal of Medicine, 331 (I), Williams-Russe, p" el aL (1992), Predicting postoperative compli
Dean, E. (1985). The effect of body position on pulmonary fUlle cations, Is it a real problem Archives of /l1Icrnal Medicine,
Physical Therapy 65, 613-{5 J 8, 152 (6), 1209-12l3,
Emerson, CL., Lukens, T.W., Effron, D, (1994), Physician estima Youtsey, J.W. (1990). Basic pulmonary function measurement In
tion of FEV I in acute exacerbation of COPD, Chest, 105(6), Scanlon, CL, Spearman, CB., & Sheldan, R.L. (Ed,.). Egan's
1709-1712, fundamentals of respiratory care. (5th ed.). SL Louis: Mosby.
c.E., et a!. (1991). Psychological outcome of a pulmonary Zadai, C (1985) Pulmonary physiology of The role of re
rehab program. Ches/, 100 (3), 613-{517, habilitation, Topics in CeriO/ric Rehabililation, 1,49-56,
Morris, J" Koski, A" Johnson, L (1971), Prediction nomograms
(BTPS) spirometric values in normal males and females. Am e r
ican Review of Respiratory Diseases, 163, 57-{57.
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Arterial Blood Gases
Donna Frownfelter
INTRODUCTION
metabolites must be kept from accumulating in high
Arterial blood gases are assessment tools to help the amounts, because the body's cardiovascular and ner
physical therapist (PT) understand the patient's vous systems operate in a relatively narrow free H+
acid/base balance, alveolar ventilation and oxygena ion range (narrow pH). Free H+ ion concentration is
tion status (Cherniak, 1992). They are valuable re discussed as pH (-log [H+]). Maintenance of body
sources of information, from respiratory monitoring systems requires an appropriate acid/base balance
in the intensive care unit to following outpatients to (Shapiro, 1994).
evaluate the therapy and progress of their diseases. Approximately 98% of normal metabolites are in
The purpose of this chapter is to help the clinician the form of carbon dioxide (C02)' Carbon dioxide re
evaluate and interpret arterial blood gases more effec acts readily with water to form carbonic acid:
tively and to integrate the information into treatment
CO2 + H20 H2C03
planning and progression of the patient.
Carbonic acid can exist either as a liquid or a gas. Be
cause carbonic acid can change to CO2, much of the
ACID/BASE BALANCE
acid content can be excreted through the lungs during
Normal body metabolism consists of consumption of respiration.
nutrients and excretion of acid metabolites. Acid The Henderson-Hasselbach equation demonstrates
153
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154 PART II Cardiopulmonary Assessment
how the H+ ion concentration results from the disso acidemia o r alkalemia. Acidosis i s a n abnormal
ciation of carbonic acid and the interrclationship of acid/base balance where the acids dominate. Alka
the blood acids, bases, and buffers: lemia is an abnormal acid/base balance where the
bases dominate. When there is a decrease in the
H2 0 + CO2 H2C03 H+ + HC03
Heo3-, it is seen in a negative base excess and referred
to as a base deficit, which is usually seen as a negative
Renal Buffering Mechanisms number on the blood gas report, that is, -3.
When interpreting a blood gas, it is helpful to de
The kidneys are the mai n route of excretion for the termine whether the patient's condition is acute or
normal metabolic acids. Hydrogen ions are excreted chronic. Another method is to examine whether the
in the urine and also resorbed by bicarbonate into situation is uncompensated, partially compensated or
the blood. In this manner, the kidneys can respond completely compensated. The pH is the key to mak
when there is an acid/base imbalance to return to ing this determination. If the pH is not in the normal
normal homeostasis. 7.35 to 7.45 range, then the patient will be in an acute
state. As it progresses back toward normal, it may be
pa11ially compensated. When a normal pH exists, it is
Normal Blood Gas Values
compensated or chronic.
Acid/base is denoted by the pH. The pH values are For example, in a patient who is retaining a CO2 of
normally 7.35 to 7.45. If the pH is below 7.35, the 55 mm Hg, the pH may read 7.25; this would be con
patient is considered to be in an acidotic state (more sidered acute. As the body retains base, the pH will
acid). If the pH is above 7.45, the patient is consid rise back toward the normal numbers. If the pH was
ered to be in an alkalotic state (more basic). 7.32 with a Peo2 of 55 and + 3 base excess, the read
Alveolar ventilation is reflected in the partial pres ing would be partially compensated. When the pH is
sure of carbon dioxide (Peo2). Normal Peo2 values within normal limits with the Peo2 of 55 and a pH of
are 35 mmHg to 45 mmHg. If the PC02 is below 35 7.35, the reading would be compensated or chronic.
mmHg the patient is said to be hyperventilating (in
creased ventilation, blowing off more C02 than nor
PARTIAL PRESSURE Of GASES
mal). If the Peo2 is above 45 mmHg the patient is hy
p o v e nt i l a t i n g , or not h a v i n g e n o u g h a l v e o l a r To better understand blood gases, it is important to
ventilation o r not blowing off enough CO2 t o main remember the properties of gases. The earth's surface
tain normal alveolar ventilation. consists of gas molecules that have mass and are at
Arterial oxygen is measured as Po2, the partial pres tracted to the earth's center of gravity. At the surface,
sure of oxygen. Normal values are 80 to 100 mm Hg. If this atmospheric weight exerts a pressure that can
the P02 is below 80 mmHg in someone less than 60 support a column of mercury 760 mm high.
years old, the patient is hypoxemic. A value of 60 to 80 Dalton'S law states that in a mixture of gases, the
mmHg total pressure is equaJ to the sum of the partial pres
would be considered moderate hypoxemia, and less sures of the separate gases. Oxygen is 20.9% of the at
than 40 mmHg is severe hypoxemja (Chemiak, 1992). mosphere, so it has a partial pressure of 159 (760 x
20.9% =159). Nitrogen is 79% of the atmosphere, so
it has a partial pressure of 600 (760 x 79% 600).
=
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9 Arterial Blood Gases 155
During respiration, oxygen and CO2 exchange with no circulation, a dead unit is credited. Figure
across the alveolar capillary membrane. Special situa 9-1 demonstrates the regional differences seen In
tions may affect the normal progress of respiration respiratory units.
and gas exchange.
Normally, alveolar units ventilate and capillary
Hemoglobin
units bring oxygenated blood to the tissues, excret
i n g C02 b a c k i nto t h e alveoli to be removed Hemoglobin (Hgb) is the main component of the red
through the lungs. However, some abnormal situa blood cell. It is crucial for oxygen transport. The nor
tions may occur, such as shunts and dead space mal Hgb is 12 to 16 gmllOO mL blood. In patients that
units. In a shunt unit, the alveoli has collapsed, but have lost blood through surgical procedures or dis
blood flow continues and is unable to pick up oxy ease, the decreased hemoglobin can account for their
gen. An example of this is atelectasis, where a lung extreme weakness as a result of decreased oxygen
segment or part of a segment has retai ned secre transport capacity. In addition, patients with advanced
tions and lung tissue distal to the mucous plug col chronic obstructive pulmonary disease (COPD) can at
lapses. Circulation continues but oxygenation does times desaturate with exercise when their Po2s are
not occur and the POl decreases. On the other hand, low; during exercise, they use increased oxygen.
a dead space unit can have ventilation but not per Cyanosis, a bluish color to the skin, mucous mem
fusion. This occurs with pulmonary embolism, branes, and nail beds, is indicative of an abnormal
where a blood clot obstructs the circulation. The amount of reduced Hgb concentration, usually greater
oxygen is available in the ventilated alveoli, but than 5 gm of reduced Hgb. The presence of cyanosis
FIGURE 9-1
A, Normal alveolus. B, Dead space. C, Shunt.
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156 PART II Cardiopulmonary Assessment
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9 Arterial Blood Gases 157
emia, if possible. This may be airway clearance tech duced less O2 is available. This is particularly impor
niques or medication, in addition to the oxygen ther tant if a patient already has a decreased P02 and is
apy. Oxygen therapy treats the hypoxemia, decreases traveling to an area with lower barometric pressure.
the patient's work of breathing, and decreases my Patients on oxygen will need an oxygen prescription
ocardial work. based on the area in which they are living.
Barometric pressure increases, such as a hyper
baric oxygen chamber with higher barometric pres
FACTORS AFFECTING ARTERIAL BLOOD GASES
sure, can be helpful in delivering increased oxygen
There are many normal causes that have an affect on for many patients. Wound-healing needs and carbon
arterial blood gases, such as extremes of age-neonatal monoxide poisoning are two .such indications.
to geriatrics. The neonate has many changes going on Increased temperatures (febrile state) can increase
in the initial life process; fetal circulation changes metabolism and therefore increase oxygen consump
dramatically in the first hours and days of life. In the tion. Decreased temperatures can decrease the oxy
geriatric patient, decreases in cardiac output (CO), gen consumption, as seen in patients involved in cold
residual volume (R V) of the lungs, and maximal water near drowning, where they survived several
breathing capacity gradually decrease P02 over the minutes under the water, and were resuscitated and
life cycle. It is estimated that after 60 years of age, resumed normal lives.
the P decreases by I mm Hg per year of age from It is important to note on the arterial blood gas
60 to 90 years. report the status of the patient when the blood gas
Exercise or any increase in activity from rest may was drawn. Usually patients are at rest when the
result in increased oxygen consumption for patients blood gas is drawn. If the P is low at rest (60 mm
with cardiopulmonary dysfunction. In the normal Hg) it is close to the sharp part of the oxyhemoglo
population, the human body compensate by increas bin dissociation curve and the patient may desatu
ing oxygen consumption to meet the workload. Usu rate with exercise.
ally, a plateau is reached and a constant oxygen con If the patient was on supplemental oxygen and the
sumption for that activity is achieved. In patients with P was only 55 mm Hg, the P02 is still inadequate
cardiopulmonary dysfunction, oxygen consumption with additional 02 (Carpenter, 1991). Similarly, if a
continues to increase even at the same workload in patient is on mechanical ventilation, the blood gases
untrained patients. It is important to monitor oxygen should be within or near normal limits.
saturation to prevent desaturation of these patients
(Guyton, 1986). During pregnancy, hormonal and
SUMMARY
mechanical factors have a negative effect on car
diopulmonary function. During the last trimester, This cha pter discussed the normal arterial blood
women often observe shortness of breath and diffi gases and what their values mean to the therapist.
culty taking a deep breath secondary to diaphrag Relationships between pH and Pe02, Pe02 and He03-,
matic encroachment. and O2 saturation and POz have been examined. We
During sleep, there is a decrease in minute ventila saw predictable changes that are caused by respira
tion and a decreased responsiveness to CO2 and hy tory changes were described. In addition we noted
poxemia. Many patients with spinal cord injury and that metabolic changes can have marked effects on
COPD have been noted to have hypoxemia during blood gases. Oxygen therapy and airway clearance
sleep studies. This should be considered in any tired techniques can improve hypoxemia, and position
or groggy patient. changes can be detrimental, causing differential
Low barometric pressure associated with high alti shunting or i m p r o v i ng the P02 by better
tude significantly decreases the amount of oxygen ventilatiOn/perfusion matching.
available to the individual. As noted before, the par As PTs, it is necessary to be acutely aware of the
tial pressure 20% of oxygen is dependent on the total respiratory monitors that can assess and progress pa
atmospheric pressure. When the total pressure is re tients safely to their optimal rehabilitation potential.
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158 PART II Cardiopulmonary Assessment
1. Which factors affect arterial blood gases? Carpenter, K.D. (199]). Oxygen transport in the blood.
2. How can exercise have a deleterious effect on Care Nurse, !J (9), 20·33,
Chernlak, R.M. (1992). Evaluation r<:'spiratory function in health
blood
and disease. Dis MOrl. (7),505-576.
3. What predictable occur between pH and
Guyton, A. (1986). Textbook of medical physiology (7th ed,),
and oxygen saturation? Philadelphia: WB Saunders.
4. What two theraDeutic t echniques can improve Shapiro, B.A. (1994), Evaluation blood gas monitors: pelfor-
mance criteria, clinical impact, and cosrlbenefit (editorial com·
ment). Crilical Care Medicine, 22 (4), 546-548,
5. What affect can body position have on blood
Shapiro, B,A" Peruai. W., & Templin, R, Clinical applicalion of
gases?
blood gases, (5th St. Louis: Mosby,
Tarpy, S,P"& Farber. H,W, (1994), Chronic lung
prescnbe home oxygen, Ceriatrics, 49 (2), 27-28,3
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Principles of Chest X-Ray
Interpretation
Michael Ries
Thomas Johnson
There are three general categories of radiographic One of the first things to check before interpreting
studies of the chest-fixed-position studies, sus the film is the quality of the film. An optimal PA
pended motion studies, and motion studies. The rou chest film is one in which the dim outline of the ver
tine posteroanterior (PA) and lateral chest film is a tebral bodies is seen through the mediastinum. Films
fixed-position, suspended motion study. The patient may be overpenetrated (of increased density) or un
is positioned with chest against the x-ray film holder derpenetrated (of decreased density) and still be ade
and is asked to hold his breath in deep inspiration. quate for interpretation. Suboptimal films may also
The radiograph (x-ray) is named from the source hide pathology and cause misinterpretation.
of the x-rays to the film. Thus a PA chest film is po The purpose of a radiograph is to see inside the
sitioned so that the source of the x-rays is 72 in. be otherwise opaque body by shifting the spectrum of
hind the patient and the film is in front. An antero light to above the high ranges of the visible spectrum,
posterior (AP) chest film is the reverse, with the thus converting the body structures into densities
back of the patient against the film. During interpre rather than colors. The densities recorded on the x
tation, the conventional position of the fi 1m on the ray film range in shades of gray to black depending
view box is as if the physical therapist (PT) were on the amount of x-ray energy the structures of the
facing the patient. body absorb as the x-ray passes through them.
159
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160 PART II Cardiopulmonary Assessment
FIGURE 10-1
Familiar fruits such as an apple, orange, pear and banana (A and C) transform into two-dimensional
objects when x-rayed (B and D). The pictures (A and C) also show a box of cherry tomatoes and a
jar of bird seed (millet seed) and their x-rays. B, is the radiograph of A, and D, is the radiograph of
C. Changes in position of the same objects from A to C illustrate the changes of shape in the
corresponding x-rays. B to D, and emphasize the need for PA and lateral x-rays for evaluating
three-dimensional structures.
There are five basic densities, varying from very third dimension, which is used to interpret the inter
radiolucent to very radiopaque. The darkest or most nal problems of a patient.
radiolucent density is gas or air. Fat is moderately ra The routine examination of the chest should in
diolucent. An intermediate or water density is seen clude a PA and lateral chest film on maximum inspi
reflecting the connective tissues, blood, muscle, skin, ration at least for the first examination. Without the
and other structures. Bone and deposited calcium are lateral film, disease processes behind the heart and
moderately radiopaque. Metal is the most opaque posterior in the thorax may be missed. Very ill pa
(white or clear). The structures of the body absorb tients who cannot be transported to the radiology de
most of the x-rays as they pass through the body, and partment must often be evaluated at the bedside from
the remainder of the rays expose the film. a single PA or AP view (taken with the portable x-ray
An example of an x-ray is the familiar fruits or unit). The size of the patient introduces mechanical
objects that have been converted into a two-dimen limitations to the performance of a lateral chest film.
sional reproduction of densities in Figure 10-1. Portable x-ray units are not as powerful as the sta
These three-dimensional structures are reduced to tionary departmental machines.
two dimensions and only the edges or structures tan Additional radiographic views may be ordered to
gential to the beam of the x-rays are recorded. Thus verify or e l u c i d a t e f i n d i n g s. These i n clud e
two views, taken at 90° from each other (PA and lat (I) oblique views, (2) apical lordotic views, (3) de
eral), are required for a mental reconstruction of the cubitus views, (4) iaminograms, (5) inspiration and
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10 Principles of Chest X-Ray Interpretation 161
FIGURE 10-2
These A, PA and B, lateral x-rays anatomically localize the basic structures that must be reviewed
during chest x-ray evaluation. Some of the structures are seen in both views and others are seen in
only one view. During evaluation, one should identify and see the foJlowing basic anatomical
structures.
Soft /issues and ex/ralhoracic s/rucltlres: soft tissues (ST), breast shadows (BS), diaphragm (D).
liver(L). and fundus of stomach (F).
Bony /homx: ribs (RI), vertebrae (V), scapulae (5, seen best on PAl, clavicles (CL. seen best on
PAl and sternum (SN. seen best on lateral).
Medias/ina! s/rucll/res: mediastinum (M), trachea (T), carina (CA). aortic knob (AK). heart (H).
anterior clear .'pace (ACS. seen on lateral) and hilus of lungs (HI).
LUlIgjields: hilus of lungs (HI). pulmon;Jry vessels (arise from hilus and branch outward).
costophrcnic angles (CPA) and lung apices (LA. seen best on PAl.
There arc many other structures that must be evaluated in addition to these basic ones, and
pathologics must be identified.
ex.piration films, (6) special studies requinng con since other pathologies may be present. All the
trast materials, (7) physiologic mOlion evaluation anatomical structures on the film should be exam
with the fluoroscopc, (8) computed tomography (CT ined. A body system approach is recommended:
scan), and (9) magnetic resonance imaging (MRI). bones and soft tissues (including the abdomen), the
Film interpretation requires a solid knowledge of mediastinum from larynx to abdomen, the cardiovas
gross anatomy and gross pathology. The PT is liter cular system, the hila, and finally, the lungs (Figure
ally examining the internal structures of the body 10-2).
without an autopsy or surgical intervention. The The tools of radiographic interpretation include
structures of the body are thus converted into the den the following:
sities of air, fat, water, calcium, and metal. The PT 1. The principle of bilateral symmetry ( when
should ex.amine the entire film, not just one area, and structures are paired, then in general one should
should not get "tunnel vision." Once an abnormality look like the other).
is found, the PT should continue to evaluate the re 2. The presence or absence of air fluid levels
mainder of the film and should not stop at that point, (there are almost no straight lines in the chest).
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162 PART II Cardiopulmonary Assessment
If a line appears to be straight, then it must be Bronchi are not usually seen unless they are sur
explained. rounded by fluid or have a disease causing thickening
3. The silhouette sign. When densities are next to of the walls. The vascular pattern may be distorted,
each other, they obliterate normal margins and blurred, increased, or decrcased by pulmonary dis
show no separation (normal silhouette of a ease. Air space or alveolar disease is manifested by
structure is obliterated). When densities or opacification (white appearance) of air-filled struc
structures are in front or in back of other densi tures of the l ung. Thus pneumonia may appear as
ties or structures, then a margin is seen. patchy coalescent areas of acini, or segmental and/or
4. An a i r b r o n c h o g r a m is seen w h e n t h e air lobar consolidation. An air bronchogram is seen
around a bronchus is pathologically filled with when the air-filled lung tissuc about the bronchus is
fluid or other material. filled with fluid or other material and the bronchus is
5. Lobar and s e g mental collapse follows the filled with air (Figure 10-3).
anatomy of the lung. Certain lung diseases cause a decrease (increase in
6. Pleural changes may be manifested by gas in a translucency) , such as emphysema (generalized) or bUl
pneumothorax, fluid in a pleural effusion, cal lae (localized). Interstitial pulmonary disease is mani
cium or soft tissue from scarring or mesothe fested by distoltion or increase in volume of tissues sur
home. A hydropneumothorax demonstrates an rounding the air spaces. An enormous number of
air fluid level. diseases can produce interstitial roentgenographic
7. The presence or absence of mass formation as changes. Sometimes a diagnosis is strongly suggested
in tumors, nodular changes or miliary changes. by the roentgenographic appearance, but in most, a his
The conventional terminology depends on the tologic evaluation is required for diagnosis. Enlarge
size of the abnormality. ment of the bronchi may result in bronchiectasis (Fig
8. Air-containing spaces such as bullae or cysts. ure 10-4). Bronchiectasis is characterized by tubular
FIGURE 10-3
A, There is total pneumonic consolidation of right upper lobe with complete alveolar and bronchial
filling. B, Approximately 24 to 36 hours later, the consolidation has cleared markedly with patchy
coalescent residual. A few air bronchograms are seen in the perihilar region.
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10 Principles of Chest X-Ray Interpretation 163
FIGURE 10-4
A, Fibrosis and saccular bronchiectatic changes are present in the left lower lobe. A few cystic
"circular" changes are present in the right upper lobe but are best seen on the bronchogram. B,
The bronchogram demonstrates the dilated abnOImal bronchi of cystic and saccular
bronchiectasis in the left lower I.obe with fibrosis around them. The right upper lobe reveals a
few cystic changes.
FIGURE 10-5
A, The PA chest film demonstrates the water density of a pneumonic consolidation in the right
lower lobe. The diaphragm is blurred. B, The lateral film shows obliteration of the posterior right
diaphragm and the costophrenic angle by the pneumonic consolidation.
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164 PART II Cardiopulmonary Assessment
Pulmonary abscesses and cavities may occur sec probably recumbent and lying slightly on the left side to
ondary to pneumonia. An abscess occurs when there aspirate materials to this area, which was first a pneumonic
process in the superior segment of the left lower lobe and
is a breakdown of the tissues of the lung, with the
progressed to an abscess cavily.
area replaced by infectious materials (of water den
sity). When the infectious materials empty into the
bronchus and air communicates with the abscess, a
cavity develops in that area of the lung. Lung ab
scesses often result from aspiration and they are catheters may result in a traumatic pneumothorax.
often found in the area s dependent at the time of the The appearance is fairly characteristic, and there may
aspiration. Thus abscesses occur in the area that is be an associated air fluid level with a hydropneu
downward by gravity, depending on the upright or mothorax (secondary to minor bleeding from the
reclining position of thc individual (Figure 10-6). If punctured lung). Pleural effwiions, or the accumula
the pleura is penetrated by the abscess, an empyema tion of fluid between the lung and chest wall, can be
develops; and if a cavity communicates with the seen in increased hydmstatic pressure (congestive
pleura, a pneumothorax de velops with a br on heart failure [CHFJ), diseases of the pleurae (malig
chopleural fistula. nancies) or diseases of the lung (emphysema sec
A pneumothorax or gas in the pleural space devel ondary to pneumonia).
ops when the pleural .'pace communicates air through Ale/ectasis is thc term used for incomplete expan
ei ther a defect in the chest wall or a defect in the sion of a portion or all of the lung. A loss of air in the
pleural surface of the lung. As the air accumulates be alveoli in the atelectatic area occurs. Atelectasis is a
tween the chest wall and the lung, the lung becomes sign of disease, since it ·is always secondary to an
compressed and moves away from the chest wall other lesion, such as (I) obstruction of a bronchus;
(separated by air) (Figure 10-7). Chronic interstitial (2) loss of ability for pulmonary expansion as a result
disease and emphysema are often complicated by a of pleural disease, diaphragmatic disease, and masses
spontaneous pneumothorax. Traumatic causes such in the thorax; or (3) volume loss from local or gener
as automobile accidents or inseltion of central venous alized pulmonary fibrosis. Atelectasis is a loss of vol
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10 Principles of Chest X-Ray Interpretation 165
FIGURE 10-8
A, The PA film demonstrates loss of the right heart border and the downward shift of the minor
fissure, with atelectasis of the right middle lobe secondary to a radiolucent foreign body in the right
middle lobe bronchus. No air remains in the middle lobe, thus it is dense. B, The arrow on the
lateral view points to the residual tissue density of the right middle lobe, which is atelectatic.
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166 PART II Cardiopulmonary Assessment
FIGURE 10-11
A, A mass is present in the left hilar area obstructing the left upper lobe bronchus. There is
atelectasis of the left upper lobe and lingula secondary to the malignancy. B, The lateral view
reveals an S-shaped curve of tumor mass and atelectasis.
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10 Principles of Chest X-Ray Interpretation 167
REVIEW QUESTIONS
severely impair the respiration of an individual (Fig Meschan, I. (1976). Synopsis of analysis of roentgen signs in gen·
eral radiology Philadelphia: WB Saunders.
ure 10-12). The abnormal shape and direction of the
Murray, J.F. & Jade, J.A. (1994). Textbook of respiratory medicine
spine interfere with the leverage necessary for move
Philadelphia: WB Saunders.
ment of the ribs with respiration. Severe impairment Paul, L.W. & Julll, J.H. The essentials of roentgen interpretation
of respiration may occur when there is fusion of the (3rd ed.). New York: Paul B Hober, 1972.
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Electrocardiogram Identification
Gary Brooks
INTRODUCTION
The ECG is an essential tool in the physician's di
The heart is a vital link in the oxygen transport sys agnosis and medical treatment of cardiac disease. In
tem, pumping blood to the pulmonary and peripheral formation provided by the ECG may also assist the
circulation systems to supply oxygen and other nutri physical therapist (PT) in the assessment of a pa
ents required for metabolism in all tissues. The beat tient's readiness for and response to physical activity.
ing heart generates rhythmic, electrical impulses that PTs in many different practice environments have ac
cause mechanical contraction, or the pumping action, cess to information afforded by the ECG. For exam
of cardiac muscle. Some of the electrical current pro ple, in an acute care or rehabilitation setting, a pa
duced by these rhythmic impulses is detectable by tient's baseline ECG, with an interpretation, may be
electrodes that may be placed on the surface of the available within the medical record. Documentation
skin. Current flow during the cardiac cycle is then accompanying a referral for outpatient physical ther
recorded as the characteristic waveforms of the elec apy may include a reference to the patient's ECG. In
trocardiogram (ECG). Mechanical events such as con other settings such as an intensive care unit or cardiac
traction and relaxation of the myocardium are infelTed rehabilitation program, ongoing monitoring of a pa
from the waveforms produced by the ECG. tient's ECG may be performed during evaluation and
169
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170 PART II Cardiopulmonary Assessment
treatment procedures. It is therefore crucial that all polarization, during which a stimulus of greater than
PTs have a basic understanding of the uses and limi normal intensity is necessary to depolarize the cell
tations of the ECG in their practices. again. The refractory period of atrial cells is signifi
This chapter briefly reviews the basic anatomy cantly shorter than that of ventricular cells allowing a
and physiology of the myocardial conduction sys more rapid intrinsic atrial rhythm than intrinsic ven
tem as it relates to the ECG. The configuration of tricular rhythm. Therefore atrial rhythms pace the
the normal ECG is presented and discussed along heart, including the ventricles, given intact atrioven
with several methods of quickly determining heart tricular (AV) conduction.
rate a n d rhythm from an electro c a r d i o g r a p h i c Closure of the slow Ca++ channels at onset of repo
record or "strip." Some o f the more common dys larization is accompanied by opening of K+ channels,
rhythmias are examined, as are some other patho causing a rapid outflow of K+, which restores resting
logic features. Throughout the chapter, the uses and negative membrane potential. During the cell's resting
limitations of the ECG in physical therapy practice phase, Na+ and Ca++ are actively pumped out of the
are highlighted. cell, and K+ is pumped into the cell, restoring ionic
gradients needed for repolarization (Shih, 1994; Guy
ton, 1991; Smith and Kampine, 1990).
PHYSIOLOGY AND ANATOMY
It is the electrical current produced by ionic
OF THE CONDUCTION SYSTEM
flow that is transmitted through the conductive tis
Generation of the Action Potential
sues surrounding the heart. This current is de
The action potential, or cardiac impulse, is generated tectable by surface electrodes, enabling the record
by ionic flow across myocardial cell membranes. In ing of the ECG.
the cell's resting state, a negative membrane potential
exists, based on the relative concentrations of sodium
The Conduction System
(Na+), Calcium (Ca++), and Potassium (K+) in the in
ternal and external cellular environments. Membrane Because myocardial cells are arranged as a syn
potential changes rapidly at the onset of depolariza cytium, an impulse propagates, or spreads to adjacent
tion, with the opening of Na+ and Ca++ channels, al cells, causing them to make contact also. This
lowing these ions to cross the membrane and enter the arrangement alone does not pellllit the heart to func
cell. Calcium then becomes available for contraction tion as an effective pump. It is the conduction system
of cardiac muscle myofibrils. During depolarization, that initiates and rapidly transmits impulses to other
the membrane's potential becomes positive and the locations within the myocardium, allowing for effec
cell contracts. As in skeletal muscle, the Na+ channels tive, coordinated myocardial contraction and pump
are fast-opening and fast-closing mechanisms, allow ing. The conduction system is comprised of special
ing Na+ to rapidly enter the myocardial cell on depo ized cardiac muscle that contracts minimally, because
larization. Unlike skeletal muscle, however, cardiac it contains few contractile myofibrils.
muscle has a prolonged depolarization phase as a re Any portion of the conduction system is capable
sult of the slower and extended opening of the Ca++ of self-excitation and may act as a pacemaker, gener
channels. During depolarization, there is also a de ating action potentials. However, because of the in
crease in membrane permeability to K+, for which trinsically more rapid rate of spontaneous depolariza
there is an outward gradient. A plateau phase of the tion of the sinoatrial (SA) node, it normally acts as
action potential exists, during which outward flow of the heart's pacemaker. The rate of depolarization of
K+ ions is inhibited. This prolongs depolarization and the SA node determines the heart rate. In the absence
delays return to the resting membrane potential. of an impulse from the SA node, the atrioventricular
Each cell has an absolute refractory period during (AV) node depolarizes spontaneously, taking over as
depolarization, meaning that an additional stimulus pacemaker, with the important difference that the rate
will not cause an additional depolarization. A brief, of depolarization is lower than that of the SA node.
but significant, relative refractory period follows de- The pathway of a normal cardiac impulse may be
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11 Electrocardiogram Identification 171
R-R
o s
I
I
I
I
I
I
FIGURE 11-1
Relationship of ECG complex to conduction pathway. (From Brown, K.R., & Jacobson. (1988).
MCI.I'lering dysrhYlhmias: A problem-soLving guide. Philadelphia: FA Davis.)
followed, highlighting its relationship to the cardiac suiti ng in a dela y i n g of the impulse b ef o r e i t
cycle. Figure I I-I displays the association of the con reaches t h e ventricular conduction system. This
duction system and its components with the ECG. pause in impulse propagation allows the atria to
Atrial depolarization is initiated by a spontaneously contract and fill the ventricles with blood_ The P-R
generated impulse that originates in the SA node. The interval of the ECG represents this period between
impulse is then transmitted throughout the atrial mus onset of atrial depolarization and the onset of ven
cle resulting in atrial contraction. This event is tricular depolarization. Normally the P-R interval
recorded as the P-wave of the ECG. The impulse is lasts between 12 and W seconds (Brown and
also transmitted, via rapidly conducting internodal Jacobson, 1988).
pathways, to the A V node. Atrial repolarization is not Following passage through the AV node, the im
recorded by the ECG, because it occurs during and is pulse continues to the Purkinje's fibers, which trans
hidden by ventricular depolarization. mit the impulse rapidly to the ventricular endo
Impulse conduction within the A V node and the cardium. This initiates ventricular depolarization,
AV bundle (bundle of His) slows considerably, re which is represented in the ECG by the QRS complex.
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172 PART II Cardiopulmonary Assessment
The depolarization wave propagates relatively slowly U-wave may be seen. The U-wave was considered
throughout the ventricular myocardium. The span of to have little physiologic or pathologic significance
time elapsing during ventricular depolarization is re (Smith and Kampine, 1990). However, U-wave in
flected by the RS interval, which normally ranges version may now be considered to correlate with
between 0.06 and 0.11 secon s n an Jacobson, myocardial ischemia (American College of Sports
1988; Smith and Kampine, 1990). Ventricular depo Medicine, 1991). Note that the ventricles remain in
larization originates in the interventricular septum, a state of contraction until slightly after repolariza
creating the Q-wave, which is normally small or ab tion. This period of contraction corresponds to the
sent. The depolarization wave next spreads to the apex Q-T interval on the ECG. Diastole, therefore, begins
and then to the right and left ventricles, causing the R subsequent to the end of the T-wave and continues
and S-waves. Depolarization also propagates in an en until the next ventricular depolarization. Note also
docardial to epicardial direction within the ventricles that atrial depolarization and contraction occur dur
(Lilly, J993; Guyton, 1991). ing diastole.
The T-wave of the ECG represents ventricular re
polarization. It is preceded by the S-T segment, dur
THE ELECTROCARDIOGRAM
ing which depolarization has been completed and
Recording the Electrocardiogram
repolarization is yet to begin. The configuration of
the S-T segment is an important marker of myocar Before examining the timing of the wave forms and
dial ischemia or infarction. Following the T-wave, a the rhythms of the ECG, a basic understanding of the
----
-
K+
.-
....
FIGURE 11-2
A normal 12-lead ECG tracing.
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]1 Electrocardiogram Identification 173
-------
principles of is needed. A stan A VR. A VL, and A VF are derived from the electrical
12-lead and sum of the three standard limb leads. The transverse
medical management of cardiac conditions. An ex plane leads are referred to as the precordial leads.
ample of a normal 12-1ead ECG is seen in 11 Imagine that each of the 12 leads "views" the heart
2. Six leads record the electrical in the frontal from a different angle, therefore
plane, and six leads record signals in the transverse different locations of the heart
plane.
The frontal plane leads include three standard limb
II, and III. Three augmented limb leads, (downward) when current travels away from a lead.
V6
V5
I-- V6
I- V5
-'\.
,.i VA
V3
Vl V2
FIGURE 11-3
leads.
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174 PART II Cardiopulmonary Assessment
Other lead configurations may be used for exercise indicates appropriate conduction of impulses from
testing (American College of Sports Medicine, 1991). atria to ventricles.
Single-lead monitoring is commonly used during ex •
What is the P-R interval? A P-R interval of greater
ercise training or in acute care settings. than 0.20 seconds indicates delay in conduction
from atria to ventricles.
I J I
m =l-
L-J- -+ -- +-+--r-t-i R !-t- lr-r 0.2second -rIlIl_
L- -+-t-t 4s , .oo n +-+- -r1
rt lIlr r1
segment segment I-++-t -nrmmnml 50.5mmmv. -+-
I--H--+--t---t-I' t
PR
ST
I I ' 0.1mv
I
, I , I! I ! I !
,
-.l
I Ll"
,
I-+- -r-rI, !.i
,
S !
j ' I!
"
PRinterval I ITi1',
-'
, '' 1
I
I 1 1 , aRS-.lInterva .:.. interla,
a. T
I
1-' 1
1.--+-++
- - 111 i ll J
' ..l
1 1
FIGURE 11-4
A normal ECG showing characteristic waves, intervals, and segments, and some of the features of
the traci ng paper.
Copyrighted Material
11 Electrocardiogram Identification 175
rate. This must be interpreted with caution, however. the rate would be estimated as falling between 100
The presence of artifact (extraneous deflections of the and 75, or close to 80 beats per minute (BPM).
waveform caused by movement or electrical intelfer In many clinics, rulers are available that are cali
ence) may render inaccurate the displayed or printed brated so that heart rate may be estimated quickly by
heart rate. This is a common problem dUling activity aligning markings on the ruler with features of the
or exercise, the circumstances during which many PTs ECG strip. For example, after the arrow on the ruler
monitor patients. It is possible to calculate or to esti is placed on an R-wave, count two R-waves to the
mate a heart rate from a printed ECG strip because, by left and read the number at that position on the ruler.
convention, the recording paper is divided into I mm In Figure 11-6, this method approximates the heart
squares and larger 5 mm squares, which are defined rate as 74 BPM.
by heavier lines (Figure 11-4). Also by convention, It is important to note that the preceding two
the standard paper speed for an ECG recording is a methods are useful only if the rhythm of the ECG
rate of 25 mm/second. Each millimeter of length then strip is regular, that is the R-waves are equally
represents 1125th, or 0.04 seconds, and each 5 mm spaced, occurring at consistent intervals. Should the
block represents one fifth, or 0.20 seconds. Some rhythm be irregular, with R-waves appearing at vary
monitor systems place a mark on the recording paper ing intervals, another method must be employed to
at 25 mm, or I-second intervals. estimate the heart rate.
There are several methods of estimating heart rate Recall that the ECG graph paper is divided into
from a printed ECG strip. On a printed ECG strip, boxes, with the horizontal spacing representing time
find an R-wave located on or near a heavy vertical intervals of 0.04 seconds for each small (I mm) box
line. Proceeding to the left of that R wave, for each and 0.20 seconds for each larger (5 mm) box. It fol
subsequent heavy vertical line, assign the following lows that I second in time is represented by five
numbers: 300 for the first heavy line encountered, larger boxes. A mark may be placed at 1- or 3-second
150 for the next followed by 100, 75, 60, 50, and 42 intervals, enabling quicker appraisal of heart rate
(Figure 11-5). Stop at the first heavy vertical line fol based on a 6-second strip. The procedure is as fol
lowing the next R wave that is encountered. The lows. Obtain a printed strip of sufficient length, cov
heart rate may be estimated as falling between the ering more than 6 seconds. If l-second marks are not
two most recently assigned values. In Figure 11-5, present, it may be convenient to place a mark at every
FIGURE 11-5
"Count-off" method of estimating heart rate.
Copyrighted Material
176 PART II Cardiopulmonary Assessment
, ,J
, ' , f' f'z', I' .. I t t t fj7r'
-F .r
+b
' r.-- 'f' T ' 'r '4rf'
, , . " •
V2
.• . .
-
• , . ' 1.. ....11
. .... ..; . t 't "
II . t'.. ,. ?r t_" 1"
.. ., '""' '/,j
._
" .-- . ..,
.. 1..
, '''lift' '''t-, . 1. ,". .!.•.
1', :;-rt·
I " t
j .. ... - . "
tH- + ,.. • .r...... ;.. -�
IfPL_, t. l
· '
1 -.1 r
;:It" -I ' - '
111111111 nil ] II r 1 1 II I I
Heart rate (two cycles from reference arrow) chart rate (25 mm/ sec)
"
"I
FIGURE 11-6
Using a rate-ruler to confirm heart rate.
FIGURE 11-7
Heart rale estimation in an irregular rhythm (atrial fibrillation).
Evaluation of Rhythms
fifth large block. Next, select a I-second mark or a
heavy vertical line on the left side of the strip, and Electrocardiographic monitoring is an impOitant evalu
proceed to the right for a length corresponding to 6 ation tool during the treatment of individuals with his
seconds. If I-second marks are counted, do not count tory of or potential for acute myocardial infarction (MI)
the starting mark or there will be only as-second or myocardial ischemia. Most cardiac deaths are a re
strip. Count the number of R-waves within the 6-sec sult of lethal arrhythmias, for which there is increased
ond recording, and multiply by lO. That is estimated risk in the presence of infarction or ischemia. Rapid
heart rate. Several 6-second strips may be analyzed to recognition of lethal an·hythmias, or arrhythmias that
document a heart rate range of an irregular rhythm may deteriorate into lethal a.rrhythmias, is essential for
(Figure 11-7). The rate of this irregular rhythm is es all health professionals involved in the care of individu
timated at 70 BPM. als with cardiac disease. The arrhythmias described in
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11 Electrocardiogram Identification 177
FIGURE 11-8
Normal sinus rhythm.
this chapter are those that must be recognized by rhythmia be a precursor to a more serious or perhaps
providers of Advanced Cardiac Life Support as deter lethal arrhythmia? Is this an acute occurrence or a
mined by the American Heart Association (Emergency chronic arrhythmia pattern? The clinical response to a
Cardiac Care Committee and Subcommittees, 1992). patient with an arrhythmia depends on the answers to
Normally, a cardiac impulse is generated by the these questions and the treatment setting.
SA node, causing atrial depolarization. This is fol
lowed by a slight delay in the A V node, after which ARRHYTHMIA IDENTIFICATION
the impulse is conducted to the ventricles causing
Supraventricular Arrhythmias
ventricular depolarization. These events are seen in
their normal spatial and temporal sequence in normal Supraventricular arrhythmias arise from an abnormal
sinus rhythm (Figure 1 1-8). A P-wave precedes every ity of impulse generation or conduction "above" the
QRS complex and every P-wave is, in turn, suc level of the ventricles. The abnormality may occur in
ceeded by a QRS complex. This occurs within an in the atria or at the level of the A V junction. Supraven
terval of 0.20 seconds (one large box), as determined tricular arrhythmias may be categorized as sinus,
by the P-R interval. The QRS complexes occur atrial, or junctional alThythmias.
within a range of 0.04 to 0.11 seconds, indicating that A cardiac rhythm may be a sinus rhythm, but with
ventricular impulse conduction and depolarization is an irregular or abnormally rapid or slow rate. Sinus ar
occurring in a normal interval. The positively de rhythmia is an in'egular sinus rhythm with varying R-R
flected T-wave indicates normal ventricular repolar intervals (Figure Il-9). This is a normal variant that is
ization. Because the SA node spontaneously depolar associated with the individual's respiratory pattern.
izes at a rate of between 60 and 100 BPM, the rate of Sinus bradycardia is a sinus rhythm occumng at a rate
normal sinus rhythm must fall within these limits. of less than 60 BPM (Figure 11-10). This rhythm may
The identification of arrhythmias affects clinical significantly reduce cardiac output, causing hemody
decision making, particularly with regards to a pa namic compromise, manifested by hypotension or
tient's readiness for and/or response to activity. Clini symptoms such as dizziness, lightheadedness, or syn
cal significance of arrhythmias range from benign to cope. On the other hand, individuals taking beta-block
lethal. The clinical significance of a given arrhythmia ers, medication that slows the heart, may exhibit this as
is determined by a number of considerations. Some their normal rhythm, as may individuals who achieve a
of these considerations include the following: Is there high level of physical conditioning. Sinus tachycardia
evidence of hemodynamic compromise? Is the ar is a sinus rhythm OCCUlTing at a rate of greater than 100
rhythmia a new or unusual finding? Might the ar BPM (Figure 11- 1 1). Sinus tachycardia, or any other
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178 PART II Cardiopulmonary Assessment
ft' 'trr.
" '' fr" '
i' "
:
-, +t-; . ,.. , '- : " ,t" " ,., ' ; - . ,. ; .. .
. ' .
t ...:.·1._ t
.• ,. f ' _
_",-,-::C' . .4 t L L· . .
.
• ' 4 ·
FIGURE 11-9
Sinus arrhythmia.
tt·
,
" ,
.... . .. "
: '!.'" L c
FIGURE 11-10
Sinus bradycardia.
f
l , of fl I,
l'"r
I I (}t L,
L
•
1
1
t::-
° L..1-L r
. "
. .J.:... L
1"�1 t _ '· L t L ' .1' I L
FIGURE 11-11
Sinus tachycardia.
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11 Electrocardiogram Identification 179
FIGURE 11-12
Premature atrial complex.
form of tachycardia, increases myocardial oxygen de abruptly and spontaneously reconverting to the previ
mand, or the workload on the heart. This may initiate ous rhythm within seconds or minutes. The P-wave is
or exacerbate ischemia in the presence of coronary often not visible, making assessment of atrial or junc
artery disease (CAD). tional origin difficult, but the duration of the QRS
A common form of arrhythmia is a "premature" complexes occurs within an appropriate interval. The
complex, that is, a beat that occurs sooner than ex R-R interval, however, is markedly shortened. Figure
pected given the established rhythm. A premature 11-13 demonstrates supraventricular tachycardia at a
atrial complex, or PAC, is an early beat of atrial origin rate of [90 BPM. Other related forms of SVT include
(Figure [1-12). An R-wave appears closer to its pre paroxysmal atrial tachycardia (PAT) and multifocal
ceding R-wave than the other R-waves in the estab atrial tachycardia (MAT). Clinically, patients with
[ished rhythm. Closer inspection reveals the presence SVT may perceive a "racing" heart rate, which may
of a P-wave associated with the QRS complex, mean be quite distressing. At very rapid heart rates, for ex
ing that the impulse first depolarized the atria before ample, greater than 170 BPM, diastolic ventricular
being conducted to the ventricles. Sometimes the AV filling time is markedly reduced, which may cause
junction may initiate an early beat, causing a premature hemodynamic compromise. Symptoms associated
junctional complex or PJc. When this occurs, the R with inadequate cardiac output, such as dizziness,
wave appears earlier; however, there may be no associ lightheadedness, and syncope may ensue. Some indi
ated P-wave, or there may be an unusual P-wave, one viduals with SVT remain asymptomatic; the rhythm
that is inverted or following the QRS complex. An in being detected incidentally, for example, during rou
verted or late P-wave indicates that the impulse was tine pulse or telemetry monitoring.
conducted in retrograde (backward) fashion. Clinically, Atrial fibrillation is the most common, clinically
a premature atrial or junctional complex may be pal encountered arrhythmia, seen in more than 5% of pa
pated as a "skipped" or early beat during pulse taking, tients over age 69. (National Heart, Lung and Blood
or the patient may perceive a palpitation or skipped Institute, Working group on atrial fibrillation, 1993)
beat. Otherwise, these arrhythmias are usually of little Atrial fibrillation is characterized by inconsistent, ir
clinical significance (Brown and Jacobson, [988). regular R-R intervals with an absence of true P-waves.
A more serious supraventricular arrhythmia is P-waves may be replaced by multiple, fibrillatory F
supraventricular tachycardia, or SVT. In this arrhyth waves of varying configuration. This arrhythmia signi
mia, the healt rate is rapid, exceeding 150 BPM. The fies that there is no established sinus or atrial pace
tachycardia may be sustained, lasting hours or even maker, rather that many impulses are simultaneous[y
days, or may be "paroxysmal" (PSVT), appearing generated from multiple locations within the atria. The
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180 PART II Cardiopulmonary Assessment
FIGURE 11-13
Supraventricular tachycardia.
atria, therefore, are not pumping effectively which, in (Figure 11-15), the QRS complex is not preceded by
turn, may impair ventricular contraction. This is be a P-wave. The AV node may generate an isolated
cause of the loss of the additional ventricular filling "escape" beat, or it may take over as the heart's pace
supplied by atrial contraction. Impulses do conduct maker. Sustained nodal or junctional rhythm is usu
through the AV junction to the ventricles; however, ally between 40 and 60 BPM, corresponding with the
this occurs inconsistently resulting in the irregular R-R inherent rate of spontaneous AV node depolarization.
interval. The ventricular response to atrial fiblillation
is important. A rapid ventricular response, resulting in
Ventricular Arrhythmias
tachycardia, may cause hemodynamic compromise
with associated symptoms or poor activity tolerance. Ventricular arrhythmias result from spontaneous de
Of additional clinical significance is the association polarization of a region within ventricular my
between atrial fibrillation and embolic cerebrovascular ocardium; a region outside the normal pathway for
accidents. Figure 11-7 illustrates atlial fibrillation with impulse generation. For this reason, the site of im
a "controlled," that is, less than 100 BPM, ventricular pulse generation is called an ectopic focus. Ventricu
response. Pulse monitoring of an individual in atrial lar arrhythmias may be distinguished from supraven
fibrillation reveals an irregularly irregular pattern. tricular arrhythmias, in that the QRS duration of a
Another arrhythmia that is characterized by abnor ventricular arrhythmia is longer than normal 0.12
mal atrial activity is atrial flutter, seen in Figure 11- seconds. The appearance of ventricular arrhythmias
14. In this rhythm, P-waves are replaced by F-waves may be characterized as being "wide and weird." It is
that have a distinctive morphology often referred to important to point out that not all rhythms with a
as a "saw tooth" or "picket fence" appearance. Of QRS duration greater than 0.11 seconds represent ec
clinical importance is the ratio of atrial to ventricular topic ventricular beats; some widened QRS rhythms
conduction and whether or not the patient is hemody result from d isturbances of impulse conduction
namically stable (Brown and Jacobson, 1988). within the ventricles, rather than from impulse gener
Because the intrinsic rate of spontaneous depolar ation within the ventricles.
ization of the AV node is less than that of the SA The reason for the widening of the QRS complex
node, spontaneous AV node depolarization is nor resulting from ventricular impulse conduction distur
mally prevented. However, in the absence of an atrial bance or impulse generation is apparent when one con
impulse the AV node depolarizes spontaneously and siders the normal conduction of a sinus impulse within
generates an impulse that then is conducted to the the ventricles. An impulse normally is rapidly con
ventricles. Thus in junctional rhythm or nodal rhythm ducted to ventricular myocardium via the Purkinje's
Copyrighted Material
11 Electrocardiogram Identification 181
FIGURE 11-14
Atrial fluller.
FIGURE 11-15
Junctional rhythm.
fibers. This assures that the impulse reaches all regions during an ectopic beat (Figure 11-16). An ECG
of ventricular myocardium in a timely fashion, with rhythm (bottom) is recorded simultaneously with the
subsequent coordinated depolarization and contraction. record of arterial blood pressure monitoring (top).
Within ventricular myocardium itself, however, propa The appearance of the "wide and weird" complex re
gation of the depolarization wave proceeds more sults in significant diminution of the corresponding
slowly, as a result of the syncytial anangement of my arterial pressure wave.
ocm'dial cells. The most common form of ventricular arrhythmia
An impulse generated within the ventricles, out is a premature ventricular complex, or PVc. In Fig
side the normal conduction pathways, initially depo ure 11-16 the wide and weird QRS complex appears
larizes surrounding local myocardium. The depolar early, interrupting the established rhythm. A pause
ization wave then spreads outward from that focus, often follows a PVC, after which the established
but is propagated at a slower velocity. Ventricular rhythm resumes. Clinically, a PVC may be perceived
contraction, in this case, is not coordinated; some re by a patient as a "skipped" beat or a palpitation. If
gions contract well b e fo re the depolarization wave pulse monitoring occurs during a PVC, the examiner
reaches regions remote from the ectopic focus. It fol will likely sense a "skipped" or irregular beat.
lows that the ventricular ejection of blood is reduced PVCs sometimes happen in patterns, occurring at
Copyrighted Material
182 PART II Cardiopulmonary Assessment
l.L I
.... ' If
t' SPEEIJ) =
j
25
I.
MM/SECOND
"
f
+ I I t1 t�-r
1"""'j
l
I +- t
L I 1_-,- Uti .J.:. L . . LL .:]
FIGURE 11-16
Diminished arterial pressure wave following a PVc.
FIGURE 11-17
Ventricul ar bigeminy.
rnl%'I@I#tllff#tmlL·'.r,· gMtmIff1F atffi lmmm.. focus are termed multifocal pyes. In this circum
stance, the waveforms will have different morphol
FIGURE 11-18 ogy according to the locations of the ectopic foci. Re
Ventricular couplet. member that the positive or negative deflection of the
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11 Electrocardiogram Identification 183
FIGURE 11-19
Multifocal PVCs.
FIGURE 11-20
Ventricular tachycardia.
waveforms depends on the direction of depolariza to most arrhythmias is beyond the scope of this chap
tion, as viewed by the lead used for monitoring. In ter; however, some arrhythmias demand an immedi
Figure 11-19 the first pve seen has an initial positive ate response if observed.
deflection, whereas the second pve seen has an ini Ventricular tachycardia (V -tach, or VT) (Figure
tial negative deflection. Each of these pves comes 11-20) is defined as three or more consecutive pves
from a different ectopic focus. at a rate greater than 100 BPM (Akhtar, 1990). This
The physical therapists's (PT's) decision-making is a serious and potentially lethal arrhythmia that may
process in response to observation of ventricular ec require emergency measures be undertaken. During
topic beats is complex and may not be easily grasped v-tach all complexes are ventricular in origin. V-tach
by the entry-level practitioner. Factors such as pres sometimes occurs in "runs" of three or more ectopic
ence or absence of symptoms, the acuity of the pa complexes followed by reversion to the baseline
tient, and whether the rhythm is a new finding all in rhythm, or it may be sustained. Effective circulation
fluence a clinical response. The presence of a pattern may be preserved, or it may be seriously compro
such as bigeminy, couplets, or multifocality is also mised or absent in sustained v-tach. A patient may be
considered. Further elucidation of clinical responses asymptomatic, particularly if only a brief run of
Copyrighted Material
184 PART II Cardiopulmonary Assessment
t-f.,r.-f+-r"*,
-'-! +O-O '--o-rl-.-...-,-
b-4';""'-"-+- :
J /.
•
. ' +- :- ..!r....
n . J
'
. ,. ,. 1 I 1\ , T
r
FIGURE 11-21
Ventricular fibrillation degenerating into asystole.
v-tach was experienced. If VT is sustained, the pa ment artifact. Unwary therapists have hastily sum
tient may be asymptomatic, symptomatic, or uncon moned help on observing v-fib or asystole, only to
scious and pulseless. The PT's response depends on feel foolish when a lead is reattached to the patient.
the rhythm, regardless of whether it is sustained, and These arrhythmias are always accompanied by loss of
the patient is symptomatic or conscious. Clinical re consciousness and pulse; a clinician should assess the
sponses range from cessation of activity, ongoing pa patient before taking action. Similarly, during activity
tient observation and immediate notification of a or exercise, movement artifact may easily be mistaken
physician to a full code. for v-tach. By assessing the patient and asking him or
Ventricular fibrillation (V-fib, VF) is a lethal ar her to "hold still," the issue may be quickly resolved.
rhythmia accompanied by immediate loss of con
sciousness and loss of circulation, that is, cardiac ar
Conduction Blocks
rest. It is characterized by disorganized, simultaneous
firing of multiple, ectopic ventricular foci; there is no Conduction blocks are another type of ECG abnor
organized rhythm (Figure 11-21). Effective ventricular mality with which PTs should be familiar. The propa
contraction ceases and cardiopulmonary resuscitation gation of a cardiac impulse may be inhibited or termi
is indicated until defibrillation is available. Death fol nated along the conduction pathway. Blockage can
lows unless defibrillation successfully restores an ef occur at the sinus node, between the atria and ventri
fective rhythm. Conditions that render the myocardium cles, Or within the ventricular conduction system.
vulnerable to ventricular fibrillation include v-tach, Sinus block occurs if the impulse cannot propagate
myocardial ischemia or infarction, dilatation of the beyond the sinus node. In this case, the AV junction
heart, hyperkalemia, or electric shock (Guyton, 1991). usually takes over as the pacemaker, and a junctional
If not successfully treated, v-fib may further de rhythm is seen with the absence of P-waves.
generate into asystole, which indicates complete ab More common are the AV blocks. They are ranked
sence of ventricular electrical activity (Figure 11-21). as first-, secondo, or third-degree, depending on the
Asystole may also occur as a primary event. This is extent of delay or obstruction of the cardiac impulse
known colloquially as "flat line" rhythm. Like ven between the atria and ventricles. First-degree AV
tricular fibrillation, asystole requires that cardiopul block is characterized by a prolongation of the P-R in
monary resuscitation begin immediately to save the terval beyond its normal 0.2 seconds (Figure I 1-22).
patient's life. Remember that the P-R interval is measured from the
Care must be taken to distinguish an apparent beginning of the P-wave to the beginning of the QRS
lethal arrhythmia from lead disconnection or move complex_ Each impulse is delayed between the atria
Copyrighted Material
11 Electrocardiogram Identification 185
FIGURE 11-22
First degree A V block.
-,:.1 l fW'
., .j. . ',
: -I--r !t+t'
' -1 ��+*'-'+
,
FIGURE 11-23
Second degree A V block, Mobitz type I.
and ventricles but each eventually reaches the ventric P-wave. The conduction ratio in Figure 11-24 is 3: I,
ular conduction system resulting in a normal QRS or three P-waves for each QRS complex. Both first
complex. Thus for each P wave, there is a QRS com and second-degree A V blocks are considered to be
plex; therefore the conduction ratio is 1: 1. incomplete heart blocks.
Second-degree A V block takes two forms, al Third degree A V block or complete heart block
though in each form, there are some sinus impulses is also known as A V dissociation. In this rhythm
that are not conducted to the ventricles. In second (Figure 11-25), P-waves are present, but there is no
degree block Mobitz type I, also known as Wencke relationship between P-waves or QRS complexes.
bach, the P-R interval lengthens progressively uotil a P-waves may be superimposed on QRS complexes,
P-wave fails to conduct to the ventricles (Figure 11- but none of the sinus impulses are conducted to the
23). Notice how the first three P-R intervals lengthen ventricles; the atria and ventricles are contracting
until, after the fourth P-wave, a QRS complex fails independently of each other. In the absence of clini
to appear. The cycle then repeats itself. Second cal intervention such as artificial pacing, ventricular
degree block Mobitz type 2 (Figure 11-24) is charac depolarization is initiated by a junctional or ventric
terized by a fixed P-R interval with a "dropped" ular pacemaker.
QRS f o llowing every seco nd, t h i r d, or f o u r t h Clioically, A V blocks range in severity from benign,
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186 PART II Cardiopulmonary Assessment
" . fi
'j.,�1 l..r-� /
,. i' L1Ji;! i
t t 1L ? rr
M , +.·::;, "ti
'
; : . L
• •: " ...... +-....
. ..
:;
....
" : .:
FIGURE 11-24
Second degree A V block, Mobitz type 2,
. ,;;Y '
t1ft
:
I. t '
-� I
FIGURE 11-25
Third degree A V block with ventricular pacing,
as is usually the case with first degree AV block, to po often treat patients with coronary hearl disease, infor
tentially lethal. Whether hemodynamic compromise oc mation regarding MI or myocardial ischemia is also
curs depends on the extent of impairment of cardiac of interest. Although PTs do not medically diagnose
output caused by too slow of a rate of ventricular con myocardial ischemia or MI, they should have a work
traction (Brown and Jacobson, 1988), Slow rates of ing knowledge of its electrocardiographic evidence.
ventricular contraction may cause lightheadedness or During myocardial ischemia, blood flow to a portion
syncope. In most cases of third degree block, treatment of myocardium is compromised, resulting in alter
now includes implantation of an artificial pacemaker. ation of myocardial metabolism. In MI, a portion of
In Figure 11-25, the needlelike spikes indicate that an myocardium has died, but an adjacent zone of is
artificial pacemaker is depolarizing the ventricles at a chemic myocardial cells endures. These ischemic
rate of 60 BPM. cells may remain "leaky," and be unable to repolar
ize. The persistent current flow from the "leaky" re
gion results in a current of injury, which is seen as a
MYOCARDIAL ISCHEMIA OR INFARCTION
shifting of the S-T segment above or below the iso
The EeG provides much more information, beyond electric line (Guyton, 1991; Lilly, 1993). S-T seg
that gleaned from arrhythmia analysis. Since PTs ment shift has significant diagnostic value. For exam
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11 Electrocardiogram Identification 187
FIGURE 11-26
S-T segment elevation during myocardial infarction.
CONCLUSION
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188 PART II Cardiopulmonary Assessment
and symptom assessment, provide entry-level PTs 7. What is the possible clinical significance of S-T
with important tools for management of patients at segment depression, of S-T segment elevation?
risk for cardiopulmonary dysfunction. What symptoms might be anticipated in the pres
ence of those conditions?
REVIEW QUESTIONS
References
1. How may the following dysrhythmias be per
ceived by a clinician without benefit of ECG Akhtar, M. (1990). Clinical spectrum of ventricular tachycardia.
• third degree A V block Cummins, R.O. (Ed.). (1994). Tex/book of advanced cardiac I'fe
SUppOrl. Dallas: American Heart Association.
• ventricular fibrillation
Emergency Cardiac Care Committee and Subcommittees. (1992).
2. What determines the clinical significance of an
Guidelines for cardiopulmonary resuscitation and emergency
arrhythmia? cardiac care, Ill: Adult advanced cardiac life support. Journal
3. What propelty of the SA node allows it to pace of/he American Medical Associa/ion, 268, 2199-224 I.
the heart? Under what conditions do other por Guyton, A.C. (199 I). Tex/book oj medical physiology. Philadel
phia: WB Saunders.
tions of the conduction system act as pacemakers?
Lilly, L.S. (1993). POIhophysiology oj hear! disease. Philadelphia:
4. Does an impulse originating within ventricular
Lea and Febiger.
myocardium generate an effective myocardial National Heart Lung and Blood Institute Working group on atrial
contraction? If not, why not? fibrillation. (1993). Atrial fibrillation: Current understandings
5. Why is ECG monitoring indicated following my and research imperatiws. Journal of AmericanCollege nfCar·
diologis/s, 22, 1830-1834.
ocardial infarction?
Shih, H.T. (1994). Anatomy of the action potential in the heart.
6. What event is represented by each of the following: Texas J-iear/lns/i/u/e lournal, 21, 30-41.
• P wave Smith, J.1., & Kampine, J.P. (1990). Circula/OI)' physiology-/he
• QRS complex essentials. Baltimore: Williams and Wilkins.
• T wave
• U wave
Copyrighted Material
C HAP T E R 1 2
Elizabeth Dean
Kidneys
INTRODUCTION
fected by virtually every organ system in the body.
The purpose of this chapter is to describe the ratio The signs and symptoms of systemic disease can
nale for multisystem assessment in the patient man mimic other conditions, including cardiopulmonary
aged for cardiopulmonary dysfunction and some dysfunction treated by physical therapists. Therefore
common laboratory tests related to multisystem as the physical therapist must be able to differentiate
sessment. The bases of tests to assess the function of these presentations to determine what treatment, if
the following organ systems are presented: blood, any, is indicated, and what treatments may be con
pulmonary, cardiac, peripheral vascular, renal, en traindicated. Knowledge of multisystem function
docrine, liver, and immune systems. The information helps confirm a diagnosis, as well as predict a pa
in this chapter is supplemental to the elements of car tient's response to treatment and his or her recovery
diopulmonary and cardiovascular assessment and re and prognosis. In addition, this information is crucial
lated laboratory investigations described in Part 2. in refining and modifying treatment prescription.
The cardiopulmonary system affects and is af- These abilities are particularly important in this era of
189
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190 PART II Cardiopulmonary Assessment
professional accountability and with the advent of di response, recovery, and prognosis. The CBC includes
rect patient access. the red blood cell count (RBC), a variety of red blood
cell indices, white blood cell count (WBe), hematocrit
(Hct), hemoglobin (Hgb), and platelet count.
RATIONALE FOR MULTISYSTEM ASSESSMENT
Tests of coagulation and hemostasis reflect bleeding
The cardiopulmonary system supports cellular respi pathology, which often involves injury of blood vessels
ration and life. Thus every system and every cell in and cells. Damage to the blood vessel wall leads to con
the body is affected by the adequacy of oxygen trans striction, a primary mechanism of hemostasis. Circulat
port, which is dependent on cardiopulmonary and ing platelets adhere to exposed subendothelial tissues,
cardiovascular function. In addition, these systems which can predispose thrombus formation.
are affected by virtually every other system in the The fluidity of the blood is regulated by the facili
body. The cardiopulmonary physical therapist (PT) tation and the inhibition of thrombin formation.
therefore needs thorough knowledge of multisystem When these two processes are in balance, the blood
function and the interdependence of the organ sys has an optimal consistency; it is neither too thick nor
tems, an ability to assess multisystem function and to too thin. This allows blood to flow optimally through
integrate this information into a comprehensive and the circulation. Blood vessel injury can disrupt this
progressive treatment plan. balance and can promote coagulation.
The lungs and heart are anatomically and physio Disseminated intravascular coagulation (DIC) re
logically interconnected, and function as a unit to sults from an imbalance between the formation and
transport oxygen via the peripheral circulation to per deposition of fibrin, which leads to the formation of
fuse and nourish tissues. Tissue homeostasis is de thrombi. The continuous production of thrombin
pendent on the adequacy of the anatomy and physiol causes depletion of the coagulation factors and bleed
o g y of t h e b l o o d . T h e a d e q u a c y of p e r i p h e r a l ing results. Tests used to assess bleeding capacity in
perfusion determines the adequacy o f the function of clude thrombin time and fibrin clotting time (partial
all organ systems in the body. Therefore a knowledge thromboplastin time [PTT]).
of the failure of the various organ systems can reflect Proteins (amino acids) serve as regulators of me
impaired oxygen transport or may identify a threat to tabolism. Much clinical information is obtained by
oxygen transport. examining and measuring proteins, because proteins
The elements of laboratory evaluation and testing, regulate many impoltant physiologic functions in the
as well as normal values, have been compiled from body. Plasma proteins serve as a source of nutrition
Bauer (1982), Dean (1987), Fishbach (1988), Guyton for the body tissues and function as buffers when
(1991 ), Jacobs et al. (1984), Le Fever Kee (1990), combined with hemoglobin.
Pagan a and Pagana ( I 992), Siest et al. (1985), and Albumin, a protein formed in the liver, maintains
Wallach (1986). normal water distribution in the body (colloid os
motic pressure). It transports blood constituents such
as ions, pigments, bilirubin, hormones, fatty acids,
ELEMENTS OF MULTISYSTEM ASSESSMENT
enzymes, and certain drugs. Approximately 55% of
Blood
total protein is albumin. The remainder is globulin,
Some common blood tests are summarized in Table which functions in antibody formation, and other
12-1 along with their normal values. plasma proteins (fibrinogen and prothrombin) in
The average blood volume consists of 5 L of blood: volved with coagulation.
3 L of plasma and 2 L of cells. Plasma is the medium Lactic acid, a product of carbohydrate metabolism, is
which suspends and transpOIts blood cells. The com produced when cells receive inadequate oxygen in rela
plete blood count (CBC) is one of the most commonly tion to oxygen demand (anaerobic metabolism). When
ordered laboratory procedures. This basic screening the production of lactic acid exceeds its removal from the
test helps to establish the patient's diagnosis, treatment blood by the liver, lactic acid accumulates in the blood.
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12 Multisystem Assessment and Laboratory Im'estigations 191
TABLE 12-1
Common Test'! of Multisystem Function and Their Normal Values: Blood Tests
Proteins
Electrolytes (blood)
:-;OTI,: Normal values may vary depending on the laboratory performing the measurement. Within subject variation occurs from age, and
variations in the pre-test sLandardization procedures.
Cholesterol is used in the production of steroid hor of cholesterol are associated with atherosclerosis and
mones, bile acids, and cell membr::mes. Cholesterol is increased risk of coronary artery disease (CAD).
found in muscles, red blood cells, and cell membranes. Electrolyte assessment is based on the electrolyte
Low-density and high-density lipoproteins (LDLs and constituents of a b lood or urine sample. Although
HDLs) transport cholesterol in the blood. High levels present in minute quantities, electrolytes are essential
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192 PART II Cardiopulmonary Assessment
in mainlaining normal cellular function and home inspection of the integrity of the peripheral circulation
oslasis. The electrolytes that are routinely studied are particularly to the eXlremities, palpation to assess pe
sodium, potassium, chloride, calcium, phosphorus, ripheral pulses, and auscultation, which can be helpful
and magnesium. in detecting bruits or areas of turbulent blood flow as
sociated with arterial stenoses.
Some common tests of peripheral vascular func
Pulmonary Function
tion are summarized in Table 12-2 along with their
See Chapters 8 and 14 for a detailed description of the normal values.
assessment of the pulmonary system and its function.
Kidney Function
Cardiac Function
Urine consists of the end products of cellular metabo
A detailed description of the assessment of the car lism and is produced as large volumes of blood (ap
diac system and its function appears in Chapters 11 proximately 25% of the cardiac output [CO]) flow
and 14. through the kidneys. When the kidneys are compro
mised, death can ensue within a few days. Although
fluid is lost through several routes, the kidneys are
Peripheral Vascular Function
primarily responsible for processing and regulating
Assessment of the peripheral vascular circulation is fluid balance in the body.
essential to provide information regarding central and Urea, the major nonprotein nitrogenous end product
peripheral hemodynam.ic of protein catabolism, is measured in the blood as blood
tissue perfusion. This assessment is essential to estab urea nitrogen (BUN). The urea is then carried to the
lish the integrity of the patient's hemodynamic status kidneys by the blood to be excreted in the urine.
at rest and during physical and exercise stress which is Creatinine is a byproduct in the breakdown of
associated with most physical therapy treatments. muscle creatine phosphate resulting from energy me
Laboratory tests include segmental blood pressure tabolism. Production of creatinine is constant as long
studies, skin temperature studies, pulse wave analysis, as muscle mass is constant. Kidney dysfunction re
Doppler venous studies, and arteriography. The physi duces excretion of creatinine resulling in increased
cal examination corroborates the results of the labora levels of blood creatinine. Analysis of urine for crea
tory investigations and includes the patient's history, tinine provides an index of kidney function.
TABLE 12-2
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12 Multisystem Assessment and Laboratory Investigations 193
Increased osmolality stimulates the secretion of marized in Table 12-4 along with their normal values.
anti-diuretic hormone (ADH) that acts on renal
Pancreatic function and insulin production
tubules. This results in the reabsorption of water,
more concentrated urine, and less concentrated serum. Insulin, a hormone produced in the pancreas by the beta
Some common tests of renal function are summa cells of the islets of Langerhans, regulates the metabo
rized in Table 12-3 along with their normal values. lism of carbohydrates along with liver, adipose tissue,
muscle, and other target cells and is responsible for
maintaining a constant level of blood glucose. The rate
Endocrine Function
of insulin secretion is determined primarily by the level
Endocrine glands are responsible for producing those of blood glucose perfusing the pancreas and is also af
substances and neuromediators responsible for main fected by hormonal status, the autonomic nervous sys
taining homeostasis and enabling the body to adapt tem, nutritional status, smoking, restricted mobility,
when physically and psychologically challenged or physical stress such as traumatic insult to the body dur
perturbed from a resting state. The key endocrine ing illness and injury, and pharmacologic agents.
glands are the pancre as, thyroid gland, and the Amylase is an enzyme produced in the salivary
adrenal glands. Endocrine glands regulate metabo glands, pancreas, and liver, and c onverts starch to
lism and are responsible for increasing blood flow sug ar. Inflammation of the pancreas or salivary
and pressure, and reducing vascular resistance when glands results in more of the enzyme entering the
metabolic demands increase. blood. The amylase test is used to diagnose and mon
Some common tests of endocrine function are sum- itor treatment of acute pancreatitis.
TABLE 12-4
Common Tests of Multisystem Function and Their Normal Values: Tests of Endocrine Function
NORMAL VALUES
TEST (SI UNITS)
Thyroid Function
Adrenal Function
Pancreatic Function
N<Y,E: Normal values may vary depending on the laboraLory peli'orming the measurement. Within subject variation occurs from age, and
variations in the pretest standarLiization procedures.
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194 PART II Cardiopulmonary Assessment
Thyroid
TABLE 12-5
The function of the thyroid gland is to take iodine
Common Tests of Multisystem Function and
from the circulating blood, combine it with amino
Their Normal Values: Tests of Liver Function
acid tyrosine, and convert it to the thyroid hormones
NORMAL VALUES
thyroxine (T4), and triiodothyronine (T3). Thyroid
TEST (SI UNITS)
hormones have a profound effect on metabolic rate.
Increased metabolism causes more rapid use of oxy Alkaline phosphatase 0.18-0.40 nmol/slL
Bilirubin (total) 5.1-I 7.1 fJmollL
gen than normal and causes greater quantities of
metabolic end products to be released from the tis
NOTl'.: Normal values may vary depending on the laboratory
sues. These effects cause vasodilatation in most of
performing the measurement. Within subject variation occurs from
the body tissues, thus increasing blood flow. Increase age and variations in the pretest standardization procedures.
in the thyroid hormones increases cardiac output,
heart rate, force of cardiac contraction, blood volume,
arterial blood pressure, oxygen consumption, and car
bon dioxide (C02) production, hence an increase in
TABLE 12-6
the rate and depth of breathing, increased appetite, Common Tests of Multisystem FUllction
food intake and gastrointestinal motility. The thyroid and Their Normal Values: Tests
gland also stores T3 and T4 until they are released of Immunological Function
into the blood stream under the influence of thyroid
Differential White Blood Cell Count
stimulating hormone (TSH) from the pituitary gland.
ABSOLUTE VALUE RELATIVE VALUE
Adrenal function (No/uL) (by Percent)
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12 Multisystem Assessment and Laboratory Investigations 195
This chapter described the rationale for multisystem 8. Describe tests of immune function.
assessment in the patient being managed for car
diopulmonary dysfunction and some common tests of
References
multisystem function. The cardiopulmonary system
affects and is affected by virtually every organ system Bauer, J.D. (1982). Clinic allaboratOlY melhods (9th ed.). St.
Louis: Mosby.
in the body. Thus primary cardiopulmonary dysfunc
Dean, E. (1987). Assessment of the peripheral circulation: An up
tion can lead to multiorgan system complications, and
date for practitioners. The Australian Journal of Physiotherapy,
dysfunction of other organ systems can have car 33, 164-171.
diopulmonary manifestations. In addition, the signs Fischbach, F. (1988). A manual of laboratory diagnostic tests (3rd
and symptoms of systemic disease can mimic other ed.). Philadelphia: J.B. Lippincott.
conditions treated by physical therapists. Therefore Guyton, A.c. (1991). Textbook of mediad physiology (6th ed.)
Philadelphia: W. B. Saunders.
the PT must be able to differentiate these presenta
Jacobs, D.S., Kasten, B.L., Demott, W.R., & Wolfson, W.L.
tions to determine whether a pathology will respond (1984). Laboratory test handbook. Stow: Lexi-Comp, Inc.
to physical therapy management, what treatment is Le Fever Kee, J. (1990). Handbook oflaboratOlY and diagnostic
not indicated and what treatments may be contraindi tests lVilh nursing implications. Norwalk: Appleton and Lange.
cated. Multisystem monitoring provides fundamental Pagana, K.D., & Pagana, TJ. (1992). Mosby·s diagno.Slic and lab
ora/Ory leSI reference. St. Louis: Mosby.
information needed to refine and progress the treat
Siest, G., Henny, J., Schiele, F., & Yonge, D.S. (1985). Inlerpretalion
ment prescription. These abilities are essential in this ofclinical laboratory lests. Foster City: Biomedical Publications.
era of increased professional responsibility and with Wallach, J. (1986). Interpretation of diagnostic tests. A synopsis of
the advent of direct patient access. laboratory medicine. Boston: Little, Brown.
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Special Tests
Gail M. Huber
INTRODUCTION
lungs, as well as determining cardiac anatomy, and
In assessing the cardiopulmonary patient, the physi direct volume and pressure measures, it is without
cian uses many tools. The patient interview, physical equal. Transesophageal echocardiography is another
examination, chest x-ray, and electrocardiogram invasive test. Following the initial assessment of the
(ECG) provide information to make a diagnosis. problem, these same special tests may be lIsed to as
When more information is needed, a variety of inva sist in the determination of appropriate therapy and
sive and noninvasive tests can be pelformed. Nuclear evaluate prognosis and response to treatment. The
medicine offers a variety of tools for evaluation of noninvasive tests are most important in determining
cardiac and pulmonary function. EChocardiography is ongoing surgical, interventional, or medical therapy.
a noninvasive method that offers information about Physical therapists (PTs) need to understand these
the cardiovascular system, including valve function, invasive and noninvasive tests for several reasons. It
ventricular performance, and estimation of filling is useful to understand how the information is used
pressures. It is particularly useful with children. to make a differential diagnosis and determine treat
At some point in a patient's workup, the physi ment. These tests have helped to clarify our under
cian may need to use an invasive test. Pulmonary standing of the physiology and pathophysiology of
and cardiac angiography is not without risk; how the system. Therapists need to understand the patho
ever, for evaluating blood flow in the heart and physiological basis f o r a p a t i e n t ' s m o v e m e n t
197
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198 PART II Cardiopulmonary Assessment
dysfunctions to select the most appropriate treat moved from time to time for patient use (Kim, 1987).
ment strategies. Many special tests can and are A generator system produces short-lived radionu
being used in research to evaluate treatment inter clides (lskandrian, 1987).
ventions. For example, radiolabeled aerosols are These elements are often attached to other sub
used to evaluate mucociliary clearance, providing a strates for transport in the body to the particular tis
method to evaluate the effectiveness of pulmonary sue of interest. The elements have differing character
hygiene techniques (Miller and O'Doherty, 1992). istics such as energy output and half-life. Because of
C linically, PTs need to use information from the their vaIied distribution in the body tissues, they pro
tests to develop a framework for predicting how the vide different information.
patient may respond to a physical therapy interven Detection of the radioactive energy emitted by a
tion. For example, nuclear imaging can provide in specific radiopharmaceutical requires a camera.
formation about left ventricular ejection fraction. When certain materials are struck by ionizing radia
This information helps the PT determine if the pa tion, light is emitted. A scintillation detector detects
tient should be stratified into high-risk or low-risk this light. A gamma camera is a scintillation detector
categories. Monitoring of an exercise session may able to detect photons exiting the body. It uses a
depend on the risk level, and interpretation of the large, collimated crystal monitored by an array of
patient's response to treatment may be effected. photomultiplier tubes (Kim, 1987). A collimator is a
device that allows only those photons traveling in an
appropriate direction to reach the crystal. There are
NUCLEAR IMAGING SYSTEMS
several types of collimators: parallel-hole collima
AN 0 RAD I 0 PHARMACEUTI CALS
tors, pinhole collimators, and converging and diverg
A general view of how nuclear imaging systems work ing collimators. The photomultiplier tube records the
should help the PT understand some of the differences amount of light from the crystal and converts it into a
between the wide variety of tests used today. This voltage, that is proportional to the intensity of the
area of medicine is experiencing rapid growth and light (Kim, 1987).
change as technology changes the equipment used to The camera system is connected to a computer
perform the test, the radiopharmaceuticals available, that stores the light images. The computer is able to
and the computer's increasing ability to analyze data. derive two dimensional images from the data. The
Radionuclide imaging allows for the noninvasive computer can also quantify the data and perform a
acquisition of images from a variety of body tissues. variety of data analyses (Iskandrian, 1987).
An imaging system requires three basic parts. The
first requirement is a radiopharmaceutical that emits
Planar Imaging
gamma radiation and is taken up by the body tissue
of interest. Next, a radiation detector or camera is A single crystal camera (Anger) produces a two dimen
needed. FinalIy, computers are required to collect and sional or planar image. Multicrystal cameras (Blau and
analyze the data. Blender) also produce planar images but are able to per
Radionuclides are elements that are unstable; they form fast dynamic imaging used in first pass and gated
gain stability by emitting particles or photons. This is studies. Planar imaging may be the only option available
called radioactive decay, and gamma radiation is re to obese patients who do not "fit" the single photon
leased. Radionuclides are either cyclotron- or genera emission computed tomography (SPECT) camera.
tor-produced. The cyclotron accelerates alpha-parti
cles, deuterons, and protons to energies suitable for
Tomographic Imaging
the production of the required radionuclide (Kim,
1987). A radionuclide generator is a system of parent If a gamma camera is rotated about the patient and
and daughter radionuclides in equilibrium. The sys mUltiple projections obtained, a three-dimensional
tem is constructed so that the daughter can be re distribution of tracer is acquired. This is the basis for
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13 Special Tests 199
SPECT (Kim, 1987). The s ame gamma-emitting TESTS OF THE CARDIOVASCULAR SYSTEM
pharmaceuticals are used. Regular gamma cameras or Radionuclide Imaging
specially designed systems can be used (Iskandrian,
Gated/ungated first pass scan
1987). SPECT imaging produces higher spatial reso
lution (Schwaiger, 1994), and increased sensitivity In an ungated first pass study, data are collected on a
for coronary artery disease (CAD) over planar images radiolabeled bolus of blood as it passes through the car
(Beller, 1994). However, attenuation artifacts (ab diac chambers. This allows for clear identification of
sorption of the radioactive energy by other body tis the four cardiac chambers. During gated first pass stud
sues such that the camera does not detect it) are ies, data are collected at specific periods in the cardiac
greater than with planar images, particularly those cycle. Each R-wave of the EKG triggers the acquisition
images involving the inferior wall of the heart in men of data, thus the average cycle observed is the compila
and the anterior wall in women, and may produce tion of several cycles. Gated equilibrium studies or
false-positive scans (Schwaiger, 1994). Quality of the multiple uptake gated acquisition (MUGA) scans aver
images are dependent on the use of stringent quality age several hundred cardiac cycles. The quality of the
control measures and experience of the staff. Image image is best when the patient has a stable sinus
quality is also patient-dependent. Patients must be rhythm. Patients with irregular heart rates, such as atrial
able to lie perfectly still for 15 to 20 minutes, with fibrillation have images of poorer quality.
For these patients, other imaging modalities such as coupled with an exercise test. A treadmill exercise
echocardiography may be appropriate. test is pelformed, and at the peak of exercise, a tracer
P o s itron e m i s s i o n t o m o g r a p h y (PET) u s e s is injected. Shortly afterward, depending on the
positron-emitting radionuclides. The images ob tracer, images are acquired. Exercise imaging en
tained by PET can provide information regarding hances the identification of ischemic areas. These
metabolism in lung tissue and cardiac muscle, my tests are then often compared with rest studies.
ocardial perfusion, and myocardial receptor density Rest/stress or stress/rest protocols can be used.
(Maddahi, 1994). PET is valuable in delineating my
Pharmacologic stress studies
ocardial areas with reversible and irreversible injury
and in assessing the feasibility of surgical revascu Many patients are unable to exercise to an intensity
larization, coronary angioplasty, or thrombolysis sufficient to produce stress on the cardiovascular sys
with respect t o potentially s a l v a g e a b le t i s s u e tem. When patients are unable to exercise, pharmaco
(Niemeyer, 1992). Many o f the radionuclides used in logic agents can be used to dilate the coronary arteries
PET scans require a cyclotron for generation and a or incr e a s e t h e metab olic demand of the heart.
specialized detection system. PET images offer s u Dipryridimole (Persantine) and adenosine are often
perior resolution compared with SPECT images used. Pharmacologic stress tests can be coupled with
(Schwaiger, 1994). PET also allows greater correc SPECT and PET nuclear imaging techniques or with
tion for attenuation artifact (Schwaiger, 1994). PET echocardiography to determine regions of ischemic
imaging is a newer technology that offers improve myocardium suggesting functionally significant block
ment in sensitivity and specificity when compared age in the coronary artery supplying that territory.
with SPECT (Mullani, 1992).
Nuclear-derived measurements
PET studies use short scanning times. Protocols
can last about I hour. The studies can be done at rest Data derived from radionuclide images provide infor
or with a pharmacologic stress agent (Schwaiger, mation about perfusion and function. Radionuclides
1994). Cost may prohibit the widespread use of this taken up by the myocardium provide a picture of the
technology. heart that includes wall thickness and an outline of
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200 PART II Cardiopulmonary Assessment
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13 Special Tests 201
TABLE 13-1
Cardiac Scans
Planar, SPEeT, MUGA, First pass
Thallium-20I Evaluates myocrdial perfusion, used in exercise stress studies and to assess
Technitium-99M-sestamibi reversibility of defects. Quantitatively can be used to determine: EF, SV,
Technitium teboroxime CO, regional function, ventricular volumes, intra-cardiac shunt, valvular
regurgitation.
PET Scans
Technetium-99M-pyrophosphate Identifies areas of infarction by binding with elements released by the death
Indium I II antimyosin of myocardial tissue.
Pulmonary Scans
Perfusion scan
Velltilation scall
Echocardiography
lium enters the cell initially and then is redistributed titatively evaluated. Normally perfused myocardium
until an equilibrium is attained based on a net bal demonstrates uniform uptake of the tracer. Uniform
ance between Thallium-201 input through recircula uptake can occur as long as blockages are less than
tion and intrinsic Thallium washout (Beller, 1994). 50% of the artery. Ischemic but viable myocardium
Finally, concentrations arc decay-related, dictated initially appears as areas of decreased uptake, these
by the half-life of the isotope (Brown, 1994; lskan areas fill in over time, a function of redistribution. Be
drian, 1987). cause blood flow is decreased, clearance of Thallium
Thallium-201 images can be qualitatively and quan 201 from the defect region is slower (Maddahi, 1994).
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202 PART II Cardiopulmonary Assessment
In infarcted areas, these defects remain unchanged in acutc situations. A patient with an acutc myocardial
over time. Qualitative evaluation requires visual in infarction (MI) can be injcctcd with tracer, given
spection of the images. Quantitative evaluation is per thrombolytics, stabilizcd, and scanned 4 hours later.
formed by computer. The computer analyzes the The scan results show myocardial pert'usion at the time
amount of radioactivity taken up in a palticuJar region of injection when the myocardium was ischemic. Later
of interest. It then quantifies this count so that regions scans demonstrate the new perfusion situation.
can be compared with each other and with normalized
Technetium-99M-teboroxime
data. In this way, unperfused or hypoperfused areas
can be identified. Another newer isotope is Technetium (Tc)-99M
Thallium-201 is used to acquire planar and tomo teboroxime. I t i s not yet widely accepted because of
graphic images (SPECT) for rest studies, exercise stress its rapid washout and visualization problems related
studies, and pharmacologic stress studies. The tradi to hepatic uptake (Berman et aI., 1991; Go, j 992).
tional Thallium-201 stress study calls for injection of The half-life for teboroxime is 5 to 6 minutes (John
the tracer at the peak of exercise with collection of the son, 1994). It has a myocardial extraction fraction
stress data shortly after. The redistribution study is com higher than either sestamibi or thallium (Johnson,
pleted 4 hours later. Newer study protocols include rein 1994). Tc-99M-teboroxime uptake parallels myocar
jection of thallium before the 4-hour redistribution study dial blood flow under both ischemic and nonischemic
(Go, 1992) and use in dual-isotope studies (Berman, conditions (Johnson, 1994) and does not appear to
1994). Reinjection of thallium and repeat imaging 24 rely on active cellular processes.
hours after initial study can help identify severely is Because of the short half-life, rapid acquisition
chemic (greater than 90% blockage) areas, which may imaging systems are required so that the images do
take much longer to demonstrate redistribution. not reflect washout. SPECT and first pass studies can
be performed but Tc-99M-teboroxime does not per
Technetium-99M-sestamibi
mit gated SPECT acquisition (Berman, 1991). Proto
New isotopes were approved by the FDA for perfusion cols using this isotope are designed to take advantage
imaging in 1990. Technetium (Tc)-99M-sestamibi was of the rapid uptake and washout. When used with
developed because of the number of advantages it has pharmacologic stress studies, a rest-stress study can
over thallium imaging. Sestamibi provides improved be completed within minutes (Johnson, (994). This
SPECT image quality as a result of higher count rates may have future application in studying reperfusion
and higher energy, in the 140 keY range. Tc-99M-ses following balloon angioplasty or reperfusion therapy
tamibi is generator-produced. The isotope has a 6-hour with thrombolytic agents (Johnson, 1994). PET trac
half-life (Berman et aI, 1994). Because of the short ers are also used to evaluate perfusion and will be
half-life, higher doses can be injected, and although the discussed below. They include, 13-N ammonia, 82
percentage of extraction is lower, sestamibi uptake in Rb rubidium, or 15-0 water.
relation to flow is similar to that of thallium. These fac
tors result in higher count rates, which thus allow the
Tests to Evaluate Myocardial Viability
use of gated images and first pass acquisition studies.
Higher count rates are preferred when evaluating obese Identification of the size of an infarct has traditionally
patients. One of the greatest limitations of Tc-99M-ses been helpful in determining prognosis. Infarct avid trac
tamibi is that it does not readily redistribute; therefore ers were used. The tracers bind with elements released
reversibility of defects cannot be ascertained as well as by necrotic myocardial tissue.
with thallium. This factor is one reason thallium is With the development of reperfusion strategies,
much more popular. Two-day protocols or dual isotope angioplasty, bypass grafting, and thrombolytic ther
protocols can be used to overcome this limitation apy it was noted that areas that appeared to be non
(Berman, 1994). Lack of redistribution has been ex functional on perfusion scans regained function once
ploited in evaluating the impact of thrombolytic therapy the area regained adequate blood supply, Tests were
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13 Special Tests 203
developed that were able to distinguish these areas of revascularization (Scheiber!, 1994).
stunned or hibernating myocardium. These tests of
11-C-Acetate
myocardial viability often look at metabolism.
According to Maddahi, four different PET ap Another way to evaluate myocardial viability is to
proaches have been used for assessment of myocar use an isotope that is incorporated into the meta
dial viability: (I) perfusion-FOG metabolism imag bolic pathways related to myocardial oxygen con
ing, (2) determination of oXidative metabolism with sumption. II-C-acetate in its activated form, acetyl
II-C-acetate, (3) uptake and retention of 82-Rb and CoA, represents the entry point for all metabolic
(4) the water perfusable tissue index (Maddahi, 1994). pathways into the tricarboxylic acid cycle, which is
tightly coupled to oxidated metabolism. It's advan
1BF-fluoro deoxyglucose
tage over 18-FOG, is that it does not rely on sub
18F-f1uoro-deoxyglucose (FOG) is a glucose ana strate use (i.e., glucose vs. fat metabolism). It accu
logue that crosses the capillary and sarcolemmal r a t ely r ef l e c t s o x i d a t i v e m e t a b o l i sm a n d c a n
membrane at a rate proportional to that of glucose. It distinguish viable from nonviable myocardium in
becomes trapped in the myocardium, because it is not b o t h a c u t e a n d c h r o ni c i s che m i c c o nd i t i o n s
a useful substrate in metabolic pathways. FOG distri (Bergman, 1994.)
bution is relative to uptake of unlabeled glucose
Technetium-99M-pyrophosphate
(Maddahi, 1994).
Identification of areas with normal metabolism, Technetium-99M-pyrophosphate (TcPyp) identifies
altered metabolism or no metabolism is based on the areas of myocardial infarction by forming a complex
use of glucose as an energy substrate. Normally, with calcium, which is released when myocardial
perfused myocardial cells use fatty acids for adeno cells die. TcPyp scans have the best results when ob
sine triphosphate (ATP) production when in a fast tained 24 to 48 hours postinfarction. This time frame
ing state and use glucose as the primary energy is obviously after reperfusion strategies would have
sour ce in the postprandial state. Ischemic m y been employed. Sensitivity of this scan is high, but
ocardium uses glucose in the fasting state and the specificity is low, since a number of other processes
postprandial state. Infarcted areas show no meta can result in a positive scan (e.g., myocardial trauma,
bolic activity. Therefore increased uptake of FOG in ventricular aneurysm, and uptake in skeletal struc
the postprandial state occurs in both hibernating and tures) (Niemeyer, 1992).
normal myocardium, but in the fasting state, it oc
Indium-111-antimyosin
curs only in the hibernating myocardium. Clinical
studies in infarct patients showed that area with per Indium III antimyosin is a radiolabled monoclonoal
sistent thallium-20 I perfusion defects have evidence antibody that identifies infarcted myocardial tissue. It
of remaining metabolic activity in 47% of regions binds with myocardial myosin, which is released when
when studied with a PET scan, indicating overesti the muscle cell dies. It can be used in conjunction with
mation of irreversible injury. Usc of reinjection and thallium-20I to distinguish infarcted tissue from per
late redistribution imaging has significantly lowered fused viable tissue. It is most reliable when performed
this number (Hendel, 1994). The implication de 48 hours after infarction (Niemeyer, 1992).
rived from this finding is that in areas with perfu
sion defects, if glucose activity remains, the region
Echocardiography
is viable (mismatch pattern); conversely, if such ac
tivity is absent, the area is likely to be infarcted or Another noninvasive method of evaluating the heart
necrotic (match pattern) (Niemeyer, 1992). Viewed uses the physical properties of sound. Echocardiogra
in functional terms, mismatch simply implies the phy provides information about blood flow, structure,
potential for improvement; rnatch implies no poten and function of the heart. Motion mode (M-mode)
tial for improvement in contractility after successful and two-dimensional (2-0) images are highly reliable
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204 PART II Cardiopulmonary Assessment
methods of evaluation. Recent developments of tech with indication of flow direction in real time (Wag
nique and technology include color flow Doppler goner, 1990). Color is matched based on the direction
echo, transesophageal echo, and intravascular of flow, and shading is indicative of intensity based
echocardiography. These techniques, when used in on the mean velocity flow estimates (Waggoner and
combination can provide much of the information Perez, 1990). It is primarily used to assess the extent
previously available only by cardiac catheterization of regurgitant jets across "leaky valves," as well as to
(Hartnell, 1994). indicate areas of abnormal shunts such as atrial septal
defects. Turbulence created by narrowed valves cre
Physics of echocardiography
ates wide color shading.
Imaging systems that use ultrasound require a source
Measurements derived from echocardiography
for generation of the sound wave, a transducer, and a
receiver to pick up the reflected sound waves. Sound Echocardiographic results can be viewed qualita
is absorbed or reflected differentially by specific tis tively and quantitatively. An experienced viewer can
sues. Therefore the sound wave reflected from mus analyze the anatomical relationships and structure of
cle differs from that reflected from vascular space, the heart, wall motion, valve movement and configu
or valvular structures. Returning signals are con ration, and chamber size.
verted into electrical signals that generate an image. Quanti tati ve measures are calculated from the
This is the basis for M-mode and 2-D echo. In M Doppler frequency shifts. Velocity measures can be
mode echocardiography, the transducer transmits a used in other equations to estimate pressure and valve
single sound wave through the chest wall. A thin area. The modified Bernoulli equation is used to cal
slice of the heart, an "ice pick" view, directly under culate pressure changes around the valve:
the sound wave, reflects the wave back to the trans
ducer. M-mode, though useful, is rarely used; 2-D is L'1 P (mm Hg) = 4 X VIllax2 (m/second),
the primary diagnostic mode. In 2-D echocardiogra where P is the pressure gradient across the valve and
phy, the transducer is able to pick up a wedge sec V is the velocity of blood flow through the valve.
tion of the heart. In 2-D the transducer acts as the
transmitter and receiver. A "real time" two-dimen These measurements allow calculation of stenotic
sional picture of the heart is recorded on videotape. valve gradients and right-sided filling pressures,
The heart can be viewed in motion, and wall motion valve regurgitation, and ventricular septal defects
can be evaluated. (Waggoner and Perez, 1990). Valve regurgitation and
Doppler echocardiography relies on the Doppler shunt calculations are more complicated than the
effect to determine velocity. W hen a sound wave is Bernoulli equation alone.
aimed at moving objects such as red blood cells, Another important quantitative measure is the
the known transmitted frequency and the reflected estimated area of the valve. The continuity equation
frequency differ, a phenomenon, known as a fre is used to estimate valve area. It is based on the
q u e n c y s h i f t . The g r e a t e r the frequency s h i f t principle of conservation of mass; that is, in a nor
the greater the speed o f the targeted object (Wag mal heart, the volume of blood that enters the right
goner and Perez, 1990). The velocity of flow is atrium should be conserved as it passes through the
the terminology used to express Doppler frequency other chambers. Flow. volume at different sites is
shifts. Both continuous wave and pulsed wave related to the flow velocity and the cross sectional
Doppler are used. area of the site. Therefore AI x VI = A2 X V2,
Color flow Doppler echocardiography was intro where VI is the velocity of flow at one side of the
duced in the mid-1980s. It is usually superimposed valve and V2 is the flow velocity at the other side
on a two-dimensional image in real time but can be of the valve, and A is the cross-sectional area
used with M-mode. It is a method that displays (W aggoner and Perez, 1990) (Wilson, Va cek,
anatomic and spatial blood flow velocity estimates 1990).
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13 Special Tests 205
Bronchoscopy
Test Procedure
Bronchoscopy is often used as both a diagnostic and
The cardiac catheterization laboratory requires an x therapeutic treatment modality (Mars and Ciesla,
ray generator tube and image intensifier/cine camera. 1993). It allows direct visualization of the trachea and
Data are stored using 35mm file (Reagan, Boxt, and its major subdivisions. Fiberoptic bronchoscopy has
Katz, 1994). virtually replaced bronchography (Lillington, 1987).
The procedure for cardiac catheterization of the In fiberoptic bronchoscopy, a flexible tube is inserted
left side of the heart requires the threading of a into the trachea of mildly sedated patients. This tude
catheter, guided by fluoroscopy, through the femoral is able to enter small brochial subdivisions. Secre
artery or brachial artcry 10 thc aorta. Direct measure tions can be removed for evalutation or as a treat
ments of chamber pressures, blood flow, and oxygen ment. It is also possible to obtain biopsy samples
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206 PART II Cardiopulmonary Assessment
using tiny forcepts or cell brushings. Bronchoscopy is standard against which ventilation/perfusion scans
particularly important in the diagmosis of bron are compared (Juni, 1992). Contrast dye is injected
chogenic carcinoma (Price and Wilson, 1986). into the pulmonary circulation through the pulmonary
artery. Additional techniques such as balloon occlu
sion, segmental injections, or increased magnification
RADIONUCLIDE IMAGING
improve the sensitivity of the test (Lillington, 1987).
Ventilation-Perfusion lung Scan
Interobserver reliability studies pelformed on the in
The ventilation-perfusion lung scan is a combination of terpretation of pulmonary angiograms are 83% to
two separate imaging procedures. It is primarily used in 86% (Juni, 1992).
the diagnosis of pulmonary embolism, with limited use
for other clinical problems (Lillington, 1987). The per
Gallium SCintigraphy
fusion portion requires the injection of radioacti ve
tracer. Technetium-99M-macroaggregated albumin is Gallium-67-citrate concentrates in neoplastic and in
(almost universally accepted as) the perfusion tracer of flammatory lesions of the lung (Lillington, 1987).
choice (Juni and Alavi, 1991). The ventilation scan re Gallium is more sensitive than normal chest x-ray in
quires the inhalation of radioactive gas, usually 133-XE identifying infectious and noninfectious inflamma
gas or Tc-99M-diethylene triamine penta-acetic acid tory processes. This is particularly important in iden
(DTPA) aerosol. Other isotopes can be used for ventila tifying opportunistic infections in the immunocom
tion scanning (e.g. Kr-8IM, Xenon-I27) but they are promised patient. In patients with acquired immune
more difficult to obtain. deficiency syndrome (AIDS) the sensitivity of gal
A normal perfusion scan essentially rules out re lium scanning for pneumocystis carinii pneumonia
cent pulmonary embolus. If the perfusion scan is ab approaches 94% to 96% (Kramer and Divgi, 1991).
normal, it is compared with the ventilation scan for The radioisotope is injected but it takes 48 to 72
match or mismatch of defects. An interpretation hours before imaging can be pelformed (Miller and
scheme is used, such as Biello or Pioped, which clas O'Doherty, 1992).
sifies the probability of pulmonary embolism into Gallium is commonly used in the evaluation of pa
normal, low, intermediate (indeterminate), or high tients with interstitial lung disease; this includes sar
(Juni, J 991; MiJJer and O'Doherty, 1992). Patients coidosis, amiodarone toxicity, and following cyto
with high probability scans should begin anticoagula toxic therapy with bleiomycin, as well as many other
tion therapy (Juni, 1991). Patients with intennediate entities (Miller and O'Doherty, 1992). In conjunction
(indeterminate) scans may need to have a pulmonary with neoplasms, the scan's use is limited to assessing
angiogram before beginning treatment (Miller and tumor extent (Kramer and Divgi, 1991).
O'Doherty, 1992).
Miller and O'Doherty (1992) note other applica
Computed Tomography
tions of ventilation/perfusion scanning to include
monitoring of response to radiotherapy and assess A computed tomography (CT) scan of the chest pro
ment of resectability of bullae. The scan is used to vides a series of cross-sectional x-ray images. Com
predict whether someone can tolerate a pneumonec pared with the standard x-ray, it is not commonly
tomy based on percent flow to the opposite lung and used in the initial diagnQsis of pulmonary disease. CT
extent of disease present. scan has been found to be a useful first-line diagnos
tic tool in the evaluation of mediastinal disease, in
cluding mediastinal masses, staging of mediastinal
Pulmonary Angiography
cancers, and identification of cysts (Lillington, 1987).
The diagnosis of pulmonary embolism is the primary High-resolution computed tomography (HRCT)
indication for pulmonary angiography. It is the gold has improved the documentation of morphologic
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13 Special Tests 207
REVIEW QUESTIONS
Magnetic Resonance Imaging
Why is the mea
sure of function?
2. What i s the difference between stunned my
ocardium and
3.
embolism?
4, Which tests can be used to evaluate myocardial
vjability?
5. Why is a good choice for eval
cardiac defects?
References
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208 PART II Cardiopulmonary Assessment
Berman, D., Kim, H., Van Train, K., Garcia, E., Friedman, J., & artery disease and left ventricular dysfunction. Jou rn al 0/ Nu
Maddahi, 1. (1991). Technetium, 99m sestamibi in the assess clear Medicine, 35, 707-715.
ment of chronic coronary artery disease. Setninars in Nuclear Mars, M., & Ciesla, N. (1993). Chest physical therapy may have
Medicine, 21,190-212. prevented bronchoscopy and exploratory laparatomy-a case re
Brown, K. (1994), The role of stress redistribution thallium-201 port. Cardiopu lmonwy Physical Therapy Journal. 4: 1,4-6.
myocardial perfusion imaging in evaluating coronary artery Mayo, .J. (1994). Magnetic resonance imaging of the chest. Ad
disease and perioperative risk. Journal of Nucfear Medicine, vances in Chesi Radiology, 32,795-809.
35, 703-706. Miller, KF., & 0' Doherty, M.l (1992). Pulmonary nuclear medi
Go, R.T., Macintyre, W.J., Cook, S.A., Neumann, D.R. (1992). cine. European Journal of Nuclear Medicine, 19, 355-368.
Myocardial perfusion imaging in the diagnosis of coronary Mullani, N.A., & Volkow, N.D., (1992). Positron emission tomog
artery disease. Currelll Opinion in Radiology. 4(4). 23-33. raphy instrumentation: a review and update. A merican Journal
Grossman, W. (1986) Cardiac Catheterization and A ngiography. of Physiologic Im aging, 314, 121-135.
(3rd cd.) Philadelphia: Lea & Febiger. Niemeyer, M.G., Van der Wall, E.E., Pauwels, E.KJ., van Dijk
Hartnell, G. (1994) Developments in Echocardiography. Radio man, P.R.M., Blokland, .l.A.K., deRoos, A., & Bruschke,
logic Clinics of Norlh America, 32,461-475. A.V.G. (1992). Assessment of acute myocardial infarction by
Hendel, R. (1994) Single-photon imaging for the assessment of nuclear imaging techniques. Angiology, 43, 720-733.
myocardial viability. Journal of Nuclear Medicine, 35(4 suppl), Port. S. (1994). The role of radionuc1ide ventriculography in the
23s-3Is. assessment of prognosis in patients with CAD. Journal of Nu
lskandrian, A.S. (1987). Nuclear cardiac imaging: principles and clear Medicil1e, 35,721-725.
app/icalions. Philadelphia: FA Davis. Price, S., & Wilson, L (1986). Pathol,hysi% gy: clinical concepts of
Johnson, L. (1994) Myocardial perfusion imaging with tech disease processes. New York: McGraw-HilI.
netium-99m-teboroxime. Journal of Nuclear Medicine, 35, Reagan, K., Boxt, L., & Katz, J. (1994). Introduction to coronary ar
689-692. teriography. Radiologic Clinics of Norlh America. 32,419-433.
Juni, J., & Alavi, A. (1991). Lung scanning in the diagnosis of pul Schelbert, H. (1994). Metabolic imaging to assess myocardial via
monary embolism: the emperor redressed. Seminars in Nuclear bility. Journal o/ Nuclear Medicine, 35(4 suppl), 8s-14s.
Medicine, 21, 281-296. Schneider, A., Hsu, T., Schwartz, S., & Pandian, N. (1993). Single,
Kerber, R. (Ed.). (1988). Echocardiography in coronary arlery biplane, multiplane, and three dimensional transesophageal
disease. Mount Kisco, NY: futura Publishing. echocardiography. Cardiology Clinics, II, 361-387.
Kim, E. (1987). Nuclear diagnostic imaging: praClical clillical ap Schwaiger, M. (1994). Myocardial perfusion imaging with PET.
plicaliolls. New York: Macmillan. Journal of Nuclear Medicine, 35, 693-698.
Kinch, J., & Ryan, T. (1994). Right ventricular infarction. New Wackers, FJ.T. (1994). Radionuclide evaluation of coronary artery
England Journal o/Medicine, 330, 1211-1215. disease in the 1990's. Cardiology Clinics. 12. 385-389.
Kramer, E., & Divgi, c. (1991). Pulmonary applications of nuclear Waggoner, A.D., & Perez, J. (1990). Principles and physics of
medicine. Clinics ill Chesl Medicine 12:1. 55-75. doppler. Cardiology Clinics, 12, 385-389.
Lillington, G. (1987). A diagnos tic approach to chest disease. Bal Webb, W.R. (1994). High-resolution computed tomography of ob
timore: Williams and Wilkins. structive lung disease. Radiologic Clinics of North A merica,
Maddahi, 1., Schelbert, H., Brunken, R., & DiCarli, M. (1994). 32, 745-757.
Role of Thallium-201 and PET imaging in evaluation of my Wilson, D., & Vacek, J. (1990). Echocardiography. Postgraduate
ocardial viability and management of patients with coronary Medicine. 87. 191-202.
Copyrighted Material
Clinical Assessment of the
Cardiopulmonary System
Susan M. Butler
INTRODUCTION
the inpatient setting, a chart review is the first point
To develop an effective treatment program for the pa of contact, whereas in the outpatient population, the
tient with a cardiopulmonary problem, it is essential information may be only what is obtainable from the
that a thorough evaluation be peliormed by the physi patient. Time management is an ever-present issue in
cal therapist (PT). This provides "baseline" data for today's era of cost containment and health care re
comparison with subsequent reassessments that occur form. Thus a medical chart review should be con
on a daily basis. Any progress or deterioration in sta ducted in an organized fashion. Most PTs develop
tus can then be easily identified with appropriate ad their own method.
justments made in the treatment plan. One strategy to chart review is the following se
quence:
1. Read the history and physical and admission
CHART REVIEW/PATIENT INTERVIEW
medical note (i.e., preadmission symptoms).
The first patient contact can be indirect, through the 2. Read the last medical note.
medical chart, or direct, through patient interview. In 3. Scan remainder of chart.
209
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210 PART II Cardiopulmonary Assessment
4. Read any reports from medical specialists, con and respiratory systems. These questions could in
sultants, i.e., pulmonologist, neurologist, oncologist. clude the following: What is the smoking history?
5. Review any pertinent lab tests. EXAMPI.ES: chest Does the patient have a family history of premature
x-ray, arterial blood gases (ABG's), complete blood coronary artery disease (i.e., a parent or sibling who
count (CBC). had a myocardial infarction)? Can the symptoms pre
6. Review medications, in particular, pulmonary sented also be signs of a cardiovascular or pulmonary
and cardiac drugs. illness? Does the patient have an active versus a
7. Review the psychosocial information (i.e., fam sedentary lifestyle? What activities precipitate symp
ily, architectural barriers). toms? Do these symptoms include breathlessness?
This last step is crucial in this time of shortened hos The patient should be seen as a human being with
pital stays. Any detail of the patient's background multiple organ systems. The patient's prob.lem,
that would affect discharge planning is crucial to whether oI1hopedic or cardiopulmonary, should not be
know even on the first day of treatment. Additional viewed in isolation. An example is the outpatient with
information to review that may be helpful and falls a physical therapy diagnosis of low back pain. When
into the cate gory of "as time allows" is the documen questioned about limiting symptoms, the patient might
tation of other allied health professionals (i.e., nurs describe cramping leg pain more suggestive of periph
ing, occupational therapy, speech pathology). Finally, eral vascular disease (PYD).
when the initial chart review is finished, a mental pic
ture of the patient should exist, even before the PT
PHYSICAL EXAMINATION
steps into the patient's hospital room.
Details regarding the patient interview have been The traditional components of a chest assessment are
covered in chapter 7. However, there are questions visual inspection, auscultation, percussion, and
that should be posed to any patient regardless of pal pation. The information provided by each of
whether their primary condition is cardiopulmonary. these techniques, when integrated with the patient's
The patient whose referring problem is musculoskele history and chal1 contents, allows the PT to piece to
tal or neurologic still must have operational cardiac gether the pieces of the puzzle. For instance, to aus
cultate breath sounds without observing the symme
try of the chest wall fails to provide the needed clues
Anatomic Structures
to the total patient picture; thereby the development
Suprasternal /lotch-A depression palpable at the of an appropriate plan of care for the patient is maqe
tip of the sternum more difficult.
Sternomanubrial angll'-A bony bump where the
Before each individual component of the assess
manubrium meets the body of the sternum; about 5
cm distal to suprasternal notch; also known as
ment is discussed, a review of the pertinent anatomical
angle of Louis; palpating hlle.ral to this junction, landmarks and topographical lines is to be discLlssed.
the .l'econd ribs is found and thus a reference point Knowledge of the superficial anatomy arid its relation
for identifying intercostal spaces and successive ship to the Llnderlying heart and lungs aids the therapist
ribs; also, a superficial marking for where the
in decision making. The topographical lines allow for
underlying trachea divides into right and left
mainstem bronchi.
more accurate description of the physical findings.
Costal angle-The angle formed by the joining of
the costal margins with the sternum; normally, no
greater than 90 degrees.
TOPOGRAPHICAL ANATOMIC LANDMARKS
Vertebra prominens-The spinous process of the
Key anatomical structures include the following:
seventh ccrvical vertebra (C7); allows numbering
of thoracic vertebra • Sternum
• Clavicles
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14 Clinical Assessment of the Cardiopulmonary System 211
-------
• Sternomanubrial angle (angle of Louis) (MAL), and posterior axillary (PAL)-Like the
MCLs, these lines are also bilateral.
• Costal angle
The posterior chest has the following three lines:
• Vertebra prominens
• Vertebral or mid-spinal line - runs through the
See the box on p. 210 and Figures 14-1 and 14-2 for
spinous processes of the vertebrae.
specific definitions and anterior and lateral views of
• Mid-scapular lines (MSL)-lie parallel to the
thorax. Imaginary topographical lines are used to
mid-spinal lines; bisect inferior angles of scapulae.
more clearly describe any physical findings (e.g., lo
cation of surgical incisions, abnormal breath sounds,
VISUAL INSPECTION
etc.) (Figure 14-3).
The anterior view of the thorax has three vertical Inspection is the foremost element of a chest assess
lines. These are the following: ment. Not only should the features of the patient be
• Mid-sternal line (MSL)-a vertical line bisecting observed, but also the equipment and any aspect of
. the sternum the patient's surroundings that would contribute to
• Mid-clavicular fine (MCL)-lies parallel to the delineating the true picture of that patient. Remem
MSL, bisects each clavicle; the lower lung borders ber, the PT has speculated a preliminary picture of
cross the sixth rib at the MCL. the patient based on chart review. Now, the ultimate
Laterally there are three vertical lines, originating test: how realistic was this initial impression? What
in their respective axillary folds: are the outward clinical signs that the therapist should
Clavicle
���-----1��n Manubrium
ManubriostemaI junction
(Angle of Louis)
Nipple
Costal angle
FIGURE 14-1
Topographical landmarks of the chest. (Adapted with permission from Seidel HM et al: Mosby's
guide to physical examination, ed 3, Boston, 1995, Mosby.)
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212 PART II Cardiopulmonary Assessment
Suprasternal notch
Clavicle
/
.1 'j,\ \ Manubrium
'_=:,. c/:.Ay".J
, Costal cartilages
Ribs
Xiphoid process
FIGURE 14-2
Anterior view of the thorax. (With permission from Swartz MH: TeXfbook ofphysical diagnoses
hi story and examination, ed 2, Philadelphia, 1994, WB Saunders.)
look for? It will be broken down into categories for patient's build-stocky, thin or cachectic? Is the pa
clarity. tient's mobility limited? Can the patient sit unsup
ported? Should the assessment be performed in stages
such as supine or alternate sidelying? Is there any extra
General Appearance
equipment in the patient's surroundings? Is the patient
Does the patient appear comfortable? Is there any facial wearing supplemental oxygen? Is the oxygen delivered
grimacing? Is the patient awake and alert or disori through a nasal cannula or a mask? What is the fraction
ented? Is there any nasal flaring or pursed-lip breath of inspired oxygen (Fi02)? Are there any monitoring
ing? These are signs of respiratory distress. Nasal flar lines and where are they located. For instance, if an ar
ing can be defined as the outward movement of the terial line is present, is it placed in the radial or femoral
nares with inspiration (Swartz, 1994). Are the accessory artery? Are there electrocardiogram (ECG) leads? Is it a
muscles of respiration (i.e, sternocleidomastoid, trapez "hard line" (directly connected to monitor) vs. teleme
ius) hypertrophied? How is the patient positioned? Is try (through radio transmitter)? Are there intravenous
the patient resting comfortably or leaning forward over (IV) sites? Are these peripheral (antecubital) or central
the bedside table and struggling for breath? What is the (subclavian or jugular)? Is there a urinary catheter?
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14 Clinical Assessment of the System 213
I
1
A
FIGURE 14·3
lines. A, Anterior view. 8, Lateral view. Posterior view. (Adapted with
permission from Swartz MH: Textbook and examination, ed 2,
Philadelphia, 1994, WB Saunders.)
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214 PART II Cardiopulmonary Assessment
Skin
desaturation has been noted, but this is not an exclu
Does the skin have a pink, healthy color versus a pal sive phenomenon. Clubbing has been o bserved in
lor? Is cyanosis present? Cyanosis is a bluish tinge non pulmonary diseases such as hepatic fibrosis and
that can be seen centrally or peripherally. Central Crohn's disease. (George, Light, Matthay, and
cyanosis is a result of insufficient gas exchange Matthay, 1990; Seidel, Ball, Dains, and Benedict,
within the lungs and is not usually seen unless oxy 1995; and Swartz, 1994).
gen saturation is less than 80%. A bluish tint may be
seen at the mucous membranes (e.g., tongue, lips).
Neck
Peripheral cyanosis, on the other hand, occurs when
oxygen extraction at the periphery is excessive. This Are the accessory muscles of respirations being re
type is also more associated with low cardiac output cruited for a resting breathing pattern? Do the stern
states. Areas to observe for peripheral cyanosis might ocleidomastoid or trapezius muscles appear promi
be fingertips, toes, nose, or nail beds. A differentiat nent? This is an early sign of obstructive lung disease
ing feature between central and peripheral cyanosis is (Swam, (994).
that peripheral cyanosis occurs, usually in the cooler
body parts such as nail beds and vanishes, usually
Jugular venous distension
when the part is warmed. In contrast, central cyanosis
does not disappear when the area is warmed. The jugular veins empty into the superior vena cava
Are any scars, bruises or ecchymoses observed? and reflect right-sided heart function. Right atrial
Are there reddened areas suggestive of prolonged pressure (RAP) is evident based on the extent to
pressure anywhere? Do the bony landmarks appear which the jugular venous pulse (JVP) can be visual
more prominent than usual? Are there any signs of ized. The more superficial external jugular veins may
trauma to the thorax or any other body parts? Does be seen superior to the clavicles; the internal jugular
the skin appear edematous? Does this edema appear veins, though larger, lie deep beneath the sternoclei
to limit joint motion? Are there any surgical inci domastoids and are less visible. Jugular venous dis
sions, new and old? Do these incisions appear to be tention (JVD) can be best seen when the patient lies
healed or seem reddened and swollen? Is there evi with the head and neck at an optimal angle of 45 de
dence of clubbing of the digits? Clubbing can be de grees (Figure 14-5). Symmetry of JVD should be
fined as the loss of angle between the nail bed and the noted. The veins are distended bilaterally if there is a
distal interphalangeal joint (Figure 14-4). The cause cardiac cause such as congestive heart failure (CHF).
of clubbing has a variety of theories, including in A unilateral distention is an indication of a localized
creased perfusion. Its association with arterial oxygen problem. (Seidel, Ball, Dains, and Benedict, (995).
the distal interphalangeal joint. This ratio is n ormally less than ribs become more horizontal and the A-P diameter
I. (Reprinted with permission from George RB et al: Chest increases, thus the term barrel chest is used. In in
medicine, ed 2, Baltimore, 1990, Williams and Wilkins.) fants, the chest is round with the anteroposterior and
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14 Clinical Assessment of the Cardiopulmonary System 215
Carotid mCfY
FIGURE 14-5
Proper positioning to observe jugular venous distention. (Reprinted with permission from Seidel
HM et al: Mosby's guide to physical examination, ed 3, Boston, 1995, Mosby.)
transverse or lateral diameters of about equal dimen pathology. Again, any asymmetry should be observed
sions. As the child grows to adulthood, the chest be from both anterior and posterior views.
comes more elliptical. Again, with the aging process, Structural defects of the anterior chest may in
the chest returns to a more rounded appearance. The clude the following: pectus excavatum, or funnel
increased anteroposterior diameter, in this population, chest-a depressed lower sternum that usually causes
is a result of the multiple factors of decreasing lung restriction only when severe; pectus carinatum, or pi
compliance, decreased strength of the thoracic and di geon chest-a prominent upper sternum which does
aphragmatic muscles and skeletal changes of the tho not restrict chest wall movement; and flail chest-the
racic spine. The sym metry of the thoracic cage chest wall moves inward with inspiration, such as
should also be noted. Asymmetry can be the result of with multiple rib fractures.
structural defects or an underlying intrathoracic Other structural defects are spinal deformities.
Copyrighted Material
216 PART H Cardiopulmonary Assessment
J )
(j>";-.
.-
t \
.JPI4/1h v
} -\,.
.
:Jil! I
(";" \,\"'\\
Jilii/
/
-
..:,:.- \ 'I
A " /
./
/' \{
/(�
./
"',r-
. \
FIGURE 14-6
Chest walJ configurations. (Reprinted with permission from Swartz MH: Textbook o/physical
diagnoses-his/ol)! and examination, ed 2, Philadelphia, 1994, WB Saunders.)
These are best viewed posteriorly. Kyphoscoliosis is Dyspnea describes the sensation of breathlessness
one example of how a posterior and lateral spinal devi or shortness of breath and is seen in cardiopulmonary
ation can limit chest wall and lung expansion. Another disorders. The level of dyspnea worsens as the sever
example is a patient with COPD, who usually has a ity of the disease increases. An easy method to docu
forward head and thoracic kyphosis (Figure 14-6). ment the level of dyspnea is to count the numbers of
words that the patient is able to speak per breath. For
instance, six-word dyspnea is not as significant as
BREATHING PATTERN
one-word dyspnea. The type of activities that elicit
Respiratory rate normally ranges between 12 and 20 shortness of breath should also be ascertained. For
breaths per minute (bpm). Eupnea is the term used to example, is breathlessness precipitated by stair climb
describe a normal breathing cycle. Apnea is a tempo ing, taking a shower, etc? The "normal" ratio of in
rary halt in breathing. Tachypnea is a rapid, shallow spiratory time to expiratory time is j :2. As the respi
breathing pattern; this is an indicator of respiratory ratory rate increases this ratio decreases to j: I. This
distress. is seen in respiratory distress, as the patient struggles
Bradypnea exists when respiration is slowed, less to breathe in, the expiratory phase is shortened, and a
than 12 bpm. Causes could be neurologic or metabolic. vicious cycle continues. With pursed lip breathing,
Kussmaul's breathing is an increased rate and depth of the idea is to prolong the expiratory phase and slow
respirations and is associated with metabolic acidosis. the breathing pattern.
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14 Clinical Assessment of the Cardiopulmonary System 217
AUSCULTATION
sists of ear pieces, tubing, and a chestpiece. The bell
Auscultation is the art of listening to sounds pro portion of the chestpiece assesses low-pitched
duced by the body. Lung and heart sounds are the sounds, that is, heart sounds. The diaphragm portion
focus of this chapter. Skill in auscultation is depen discerns high pitched sounds (Figure 1 4-7). The tub
dent on the following four factors: ing should not be so long that sound transmission is
I. A functional stethoscope not dampened. Length of tubing should be between
2. Proper technique about 30 cm (12 in) to 55 cm (21 to 22 in). The ear
3. Knowledge of the different categories of lung pieces should fit the PT's ears comfortably and allow
sounds: normal, abnormal, and adventitious tuning out of external sounds. Other considerations
breath sounds and voice sounds would be to position the ear pieces anteriorly or for
4. Knowledge of the different categories of heart ward toward the ear canals. Finally, an aside gained
sounds and murmurs from the author's clinical experience: warming the
diaphragm with the hands before placing it on the pa
tient's skin is a first step in developing good patient
Stethoscope
rapport.
A stethoscope need not be fancy to be effective. A
PT, skilled in auscultation, can use any basic stetho
Technique
scope and be able to identify lung sounds. The stetho
scope functions more as a filter to the extraneous Environment is another element in the correct pedor
noises than as an amplifier. A basic stethoscope con- mance of auscultation. The room or cubicle should be
as quiet as possible. Television and radio should be
turned down or off. Any extraneous noises should be
minimized or eliminated. This is especially important
when auscultation is a new technique for the thera
pist. The patient should be positioned sitting, if possi
ble, for lung sounds. The anterior, lateral, and poste
rior aspects of the chest should be auscultated both
craniocaudally (apices to bases) and side to side (Fig
ure 14-8). The PT places the diaphragm on the pa
tient's skin so that it lies flat. The patient is instructed
to breath in and out through the mouth. A slightly
deeper breath than tidal breathing is suggested. A
minimum of one breath per bronchopulmonary seg
ment allows for a comparison of the intensity, pitch,
and quality of the breath sounds. Movement of the di
aphragm from one side to the other side while, at the
same time, moving it craniocaudally, enables the PT
to compare the right to the left chest. Clothing should
be removed and/or draped so that it does not interfere
Tubing in the assessment of the breath sounds.
FIGURE 14-7
Chest Sounds
Stethoscope. (Replinted with permission from Wilkins RL,
Hodgkin JE, Lopez B: Lung sOllnds, St. Louis, 1988, Mosby.) Chest sounds may be divided into these categories:
Copyrighted Material
218 PART II Cardiopulmonary Assessment
A
B
FIGURE 14-8
Stethoscope placement for auscultation of breath sounds. A, The chest. B, The back. (From
Buckingham EB: A primer of clinical diagnosis, ed 2, New York, 1979, Harper & Row.)
I. Breath sounds-normal , abnormal, adventi piratory phase. A distinguishing feature is the pause
tious that exists between the inspiratory and expiratory
2. Voice sounds - egophany , bronchophany, phases (Figure 14-9). This sound is also described as
whispered pectoriloquy tracheal as its norma/ location is over the trachea.
3. Extrapulmonary sounds-pl eural or friction Brol1chovesicular suunds are similar in that these are
rubs also high-pitched and have an equal inspiratory and
4. Heart sounds expiratory cycles. However, a differentiating feature
is the lack of a pause (Figure 14-9). Brol1chovesicular
sounds are heard best wherever the bronchi or central
Breath Sounds
lung tissue is close to the surface. These include su
The terminology of breath sounds given in this chap perior to the clavicles and suprascapular (apices), and
ter is a compilation of multiple resources and clinical parasternal and interscapular (bronchi). The ATS
experience. Recognition of normal breath sounds is AACP, in its 1977 recommendations for pulmonary
the key to the identification of abnormal and adventi nomenclature, used the term bronchial to include
tious sounds by offering the listener a point of refer both bronchial and bronchovesicular sounds. The fi
ence. Normal breath sounds can be broken down into nite difference is minor (the pause between the inspi
bronchial, bronchovesicular, and ves icular_ The ratory and expiratory phases). This recommendation
American Thoracic Society (ATS) and the American is meant to provide uniformity to lung sounds tenni
College of Chest Physicians (ACCP) has attempted to nology. Vesicular brealh suunds are heard over the
provide standardization of the nomenclature and con remaining peripheral lung fields. These sounds have
tinues to conduct surveys of health care professionals primarily an inspiratory component with only the ini
for use of this terminology in clinical practice. tial one third of the expiratory phase audible. Their
Bronchial sounds can be described as high intensity is also softer because of the dampening ef
pitched and are heard both in the inspiratory and ex fect of the spongy lung tissue and the cumulative ef
Copyrighted Material
14 Clinical Assessment of the Cardiopulmonary System 219
~
loud, high pitched; hollow quality; pletely. In a consolidation type of pneumonia, the
heard over manubrium; louder on lung tissue is Hairless" because of the complete ob
expiration; distinct pause between
struction of segmental or lobar bronchi by secretions.
inspiration (I) and expiration (E)
Sound from the adjacent bronchi is enhanced and be
comes more high-pitched and the expiratory compo
BRONCHOVESICULAR nent louder and more pronounced. Compression of
/\
mixture of bronchial and vesicular; I:
lung tissue from an extrapulmonary source also pro
E is 1: 1; heard over main-stem bronchi
-- anteriorly: ICS # 1 and 2, posteriorly: duces bronchial sounds. Examples include compres
between scapulae sion secondary to increased pleural fluid (pleural ef
fusion) or tumor. Tubular breath sounds is a term
used synonymously to describe abnormal bronchial
/'
soft, low pitched; heard over peripheral Decreased or absent breath sounds occur when
lung tissue; no pause between I and E; sound transmission is diminished or abolished. De
ratio is 3: 1
creased breath sounds are when the normal vesicular
sounds are further diminished. Absent sounds are
FIGURE 14-9 when no sounds are audible. Decreased or absent
Normal breath sounds. sounds can be caused by an internal pulmonary
pathology or can be secondary to an initially nonpul
monary condition. Hyperinflation caused by emphy
sema causes decreased sound transmission as a resull
of the destruction of the acinar units and increased air
as a result of loss of normal lung structure. The loss
fect of the air entry from numerous terminal bronchi of lung compliance resulting from pulmonary fibrosis
oles. The idea that vesicular sounds reflect air entry also may produce decreased or absent breath sounds.
in the alveoli has been disproved. Thus as the thera Extrapulmonary causes include tumors, neuromuscu
pist auscultates from top to bottom, the breath sounds lar weakness (i.e, muscular dystrophy), and muscu
are quieter at the bases than at the apices. Infants and loskeletal deformities (i.e., kyphoscoliosis). Pain is a
small children have louder, harsher breath sounds. common cause for decreased or absent breath sounds.
This is as result of the thinness of the chest wall and When the patient attempts to take a deep breath, the
the airways being closer to its surface. volume is limited because of the onset of pain. The
etiologic factors of the pain can be varied-from in
cisional (i.e., midsternotomy) to traumatic (fractured
Abnormal Breath Sounds
ribs). Given that no underlying pathologies are pre
Abnormal breath sounds can be described as when sent, decreased breath sounds may also be a reflec
the sound transmission changes as a result of an un tion of the depth of respiration and/or the thickness of
derlying pathologic process. Sound is filtered by the the chest wall (e.g., in obesity or with the presence of
lung tissues because these organs are air-filled; thus bandages). The skill of auscultation lies in the differ
there is dampened sound transmission over the bases entiation b etween normal and abnormal breath
versus the apices. On the other hand, sound transmis sounds.
sion is enhanced when a liquid or solid is the
medium. Certain lung pathologies produce abnormal
Adventitious Breath Sounds
lung sounds. Abnormal sounds can be divided into
three types: bronchial, decreased, and absent. Adventitious breath sounds are the extraneous noises
Bronchial sounds occur in peripheral lung tissue produced over the bronchopulmonary tree and are an
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220 PART II Cardiopulmonary Assessment
indication of an abnormal process or condition. These three." Egophany is also described when there is in
sounds may be more easily identifiable than abnor creased transmission of the vocal vibrations. In this
mal sounds. Adventitious sounds are classified as case, the patient is asked to say "eeee." The underly
c rackles (rales), rhonchi, and wheezes. Crackles ing process distorts the "e" sound so that an "aaa"
(rales) are described as discontinuous, low-pitched sound is heard over the peripheral area by the exam
sounds. They occur predominantly during inspiration. iner. Egophany co-exists with bronchophany.
The sound of rubbing hair between the fingers or vel Whispered voice sounds also produce low-pitched
cro popping simulates crackles. Crackles usually in vibrations over the chest that are muftled by normal
dicate a peripheral airway process. Rhonchi are low lung parenchyma. Whispered pectoriloquy describes
pitched but continuous sounds. These occur both in when these whispered voice sounds become distinct
inspiration and expiration. Snoring is a term used to and clear; "one, two, three" or "ninety-nine" are used
describe its quality. Rhonchi are attributed to an ob to evaluate this sound. Whispered pectoriloquy can
structive process in the larger, more central airways. be present when bronchophany and egophany are ab
Wheezes are continuous but high-pitched. A hissing sent. This sign is helpful in identifying smaller or
or whistling quality is present. Wheezes predomi patchy areas of lung consolidation.
nantly occur during expiration and are an indication Voice sounds are a means of confirmation of the
of bronchospasm (i.e., asthma). However, wheezes abnormal breath sounds. If a patient with significant
can also be caused by the movement of air through atelectasis secondary to compression of lung tissue
secretions, thus inspiratory wheezes can be described. presents with bronchial breath sounds, then egophany
and bronchophany are also audible.
Extrapulmonary Sounds
HEART SOUNDS
An adventitious sound that is nonpulmonary is the
friction rub. It can be described as a rubbing or leath As with lung sounds, superficial topographical land
ery sound and occurs during both inspiration and ex marks assist the therapist in auscultation of heart
piration. The sound is produced by the visceral sounds and murmurs. The left ventricular apex is nor
(inner) pleural lining rubbing against the parietal mally located at the MCL in the fifth intercostal
(outer) pleura and is a sign of a primary pleural space (rCS). The cardiac apex is also known as the
process such as inflammation or neoplasm. Pain is point of maximum impulse (PM/). There are four ref
usually associated with a friction rub. erence areas for cardiac auscultation; these do not
c o r r e s p o n d directly to the u n derlying cardiac
anatomy. On the other hand, these areas do relate to
Voice Sounds
the events arising at the individual cardiac valves.
Voice sounds are vibrations produced by the speak These four areas are defined as the following:
ing voice as it travels down the tracheobronchial tree • aortic: second rcs, at right sternal border
and through the lung parenchyma when heard with a (RSB)
stethoscope. These sounds, over the normal lung, are • pulmonic: second ICS, at left sternal border
low-pitched and have a muftled or mumbled quality. (LSB)
The transmission of these vocal vibrations can be in • tricuspid: fourth and fifth lCS, LSB
creased or decreased in the presence of an underlying • mitral: cardiac apex fifth ICS, MCL.
pulmonary pathologic process. Bronchophany de
scribes the phenomenon of increased vocal transmis
Technique
sion. Words or letters are louder and clearer. Causes
are conditions where there is an increased lung den An environment that is as quiet as possible is recom
sity as in consolidation from pneumonia. The patient mended. Positions used for cardiac auscultation in
is usually asked to repeat "blue moon" or "one, two, clude the following: supine-used for all areas; left
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14 Clinical Assessment of the Cardiopulmonary System 221
lateral decubitus (sidelying)-iistening to cardiac ever, it is usually abnormal in individuals over age
apex or mitral area, bell usually used; and sitting 40. An extra effort must be made to auscultate S3; the
used for all the areas. bell of the stethoscope should be used. The ideal po
sition to hear S3 would be left side1ying; the bell
would be placed over the cardiac apex. Causes of a
Heart Sounds
pathological S3 may include ventricular failure,
The first heart sound (Sl) signifies the closing of the tachycardia, or mitral regurgitation. "Ken-TUCK'-y"
atrioventricular valves. Its duration is O. 10 seconds; it is one sound that has been used to approximate the
is heard the loudest at the cardiac apex. The two com sound sequencing of S3 in the cardiac cycle (SJ, S2,
ponents of Sl are tricuspid and mitral. Both the di S3).
aphragm and the bell of the stethoscope can be used The fourth heart sound (S4) signifies the rapid ven
to hear Sl. Its loudness is enhanced by any condition tricular filling that occurs after atrial contraction.
in which the heart is closer to the chest wall (i.e., thin When present, it is heard before Sl. S4 may be heard
chest wall) or in which there is an increased force to in the "normal" trained individual with left ventricu
the ventricular contraction (e.g., tachycardia resulting lar hypertrophy. Location of S4 is similar to S3' Its
from exercise). sound can be described as dull because of the sudden
The second heart sound (S2) represents the clos motion of stiff ventricles in response to increased
ing of the semilunar valves and the end of ventricu atrial contraction. Pathologies eliciting an S4 may in
lar systole. Its components are aortic and pulmonic. clude systemic hypertension, cardiomyopathies, or
During expiration, these two components are not coarctation of the aorta. "TENN'-ess-ee" is a sound
distinct, since the time difference in the closure of that approximates the sound sequencing when S4 is
the valves is less than 30 milliseconds. However, present (S4, Sb Sz).
during inspiration, a splitting of S2 is audible. This
physiological split results from the increased venous
Murmurs
return to the right heart secondary to the decreased
intrathoracic pressure that occurs during inspiration. Cardiac murmurs are the vibrations resulting from
The pulmonic valve closure is delayed as the right turbulent blood flow. These may be described based
ventricular systolic time is lengthened. A split S2 is on position in cardiac cycle (systole, diastole), dura
heard normally in children and young adults. The tion, and loudness. SYSlolic murmurs occur between
diaphragm of the stethoscope shou ld be used to hear Sl and S2; diastolic murmurs occur between Sz and
the split. The pulmonic component is the softer SJ' A continuous murmur starts in SJ and lasts
sound and is best heard at the LSB, in the second to through S2 for a portion or all of diastole. The loud
fourth ICS. The two components may be heard best ness of a murmur is a factor of the velocity of blood
in the aortic and pulmonic areas, respectively. When flow and the turbulence created through a specific
the split is heard both phases of respiration. an un opening such as a valve. Grades I to VI are described
derlying cardiac abnormality is suspected. Causes as folJows:
may include right bundle branch block and pul •
I: faint-requires concentrated effort to hear
monary hypertension. ( S w a r tz, 1994; T i lki a n , •
II: faint-audible immediately
Conover, 1993). •
III: louder than II-intermediate intensity
•
IV: loud-intermediate intensity; associated with
Gallops palpable vibration (thrill)
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222 PART II Cardiopulmonary Assessment
MEDIATE PERCUSSION
%
•
resonant: loud or high amplitude, low-pitched,
longer duration, heard over air-filled organs such /.
as the lungs
•
dull: low amplitude, medium to high-pitched,
short duration, heard over solid organs such as the
liver
•
flat: high-pitched, short duration, heard over
FIGURE 14-10
muscle mass such as the thigh
Mediate percussion technique. (Reprinted with permission
•
tympanic: high-pitched, medium duration, heard from Swartz MH: Textbook of physical diagnoses-history
over hollow structures such as the stomach and examinaliol1, ed 2, Philadelphia, 1994, WB Saunders.)
•
hyper-resonant: very low-pitched, prolonged
duration, heard over tissue with decreased density
(increased air: tissue ratio); abnormal in adults;
heard over lungs with emphysema.
Copyrighted Material
14 Clinical Assessment of the Cardiopulmonary System 223
Inspiration Expiration
FIGURE 14-11
Diaphragmatic excursion. (Reprinted with permission from Swartz MH: Textbook of physical
diagnoses-history and examination, ed 2, Philadelphia, 1994, WB Saunders.)
Tenderness
is a crunchy sound often associated with articular
Specific superficial or deep landmarks are identified structures. However, when bubbles of air occur
through palpation. Determination of gross spinal within subcutaneous tissue, a crackling sensation can
alignment can be performed by tracing the spinous be palpated. An air leak from a chest tube site is one
processes in a cephalocaudal direction. Structures can cause when crepitus is palpated over the chest wall.
be identified, such as the T-4 vertebra or the sternal Crepitus can also be secondary to a pleural or friction
angle, which only augment the PTs evaluation. Areas rub.
of tenderness can be assessed for degree of discom
fort and reproducibility. Differentiation of chest wall
Edema
discomfort of an organic nature, such as with angina,
from that of a musculoskeletal condition may b e Palpation allows the PT to assess petipheral edema.
made through palpation. I n a patient complaining of Dependency of body parts can cause swelling from
chest pain, angina may be ruled out if the PT can re cardiac and noncardiac conditions. Assessment of
produce or increase the discomfort with increased edema is performed by pressing two fingers into the
tactile pressure. However, one must also determine particular areas for 2 to 3 seconds. If an impression is
that corroborating symptoms (e.g., diaphoresis, left once the fingers are removed, then pitting or de
tachycardia) are not present. Angina or chest pain pendent edema is present. The degree of edema is
secondary to myocardial ischemia usuaJly results based on the length of time that the indentation lasts.
from exertion and may be relieved by rest. Crepitus I + is the least; 4+ is the worst.
Copyrighted Material
224 PART II Cardiopulmonary Assessment
Chest Wall Excursion of the sternal angle and meet at the midline,
slightly stretching the skin.
Evaluation of thoracic expansion allows the
4. The patient is asked to inhale.
to observe a "baseline" level by which to measure
5, The hands should be relaxed to allow for
progress or decline in a patient's condition. Chest
movement beneath,
wall movement can be restricted unilaterally as a re
6. The symmetry and extent of movement are
sult of lobar or a surgical incision. A
assessed.
decrease in chest wall motion occurs in
withCOPO.
The hyperinflation associated withCOPO
an increase in the diameter with a pro-
loss of excursion. Normal
chest wall excursion is about 3.25 inches em) in a
young adult between 20 to 30 years of age. One
method is to use a measure at the level of the
xiphoid. However, the most common method involves
direct hand contact. This technique is in all
planes and from top to bottom. Symmetry and extent
of movement are both noted. Procedures for this
method are described in the
or upper lobe motion
I. The PT faces the patient. The area to be
examined is and as needed.
2. The PT's hands are over the anterior
FIGURE 14-13
chest. The heel of the hand is about the level
Evaluation of middle lobe and lingula motion (anterolateral
of the fourth rib and the fingertips reach excursion), (From Cherniak RM, et al: Respiration ill health
toward the upper and disease, ed 2, Philadelphia, 1972, WB Saunders.)
3, The thumbs Jie horizontal at about the level
\ I
J±�
I ' i
A
FIGURE 14-12 FIGURE 14-14
Evaluation of upper lobe motion. (From Cherniak RM, et Evaluation of lower lobe motion (posterior
al: in health and disease. ed 2, (From Cherniak RM, et al: Respiration in health and
1972, WB Saunders,) disease. ed 2, Philadelphia, ]972, WB Saunders.)
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14 Clinical Assessment of the Cardiopulmonary System 225
Tactile Fremitus
Spoken word produces vibration over the chest wall. aspect of the suprasternal notch. This is repeated on
Voice sounds have been previously discussed under the opposite side. An equal distance between the
auscultation. With the PTs hands placed on the chest clavicle and the trachea should exist bilaterally. Tra
wall, vibrations from spoken words can be felt and cheal deviation may be caused by a pneumothorax,
are described as tactile fremitus. The presence or ab atelectasis or a tumor among other conditions.
sence of tactile fremitus provides information on the Whether the deviation will be ipsilateral or contralat
density of the underlying lungs and thoracic cavity eral depends on the underlying cause. A right pneu
(Swartz, 1994). mothorax or pleural effusion will deviate the trachea
away (toward the left); a left lower lobe atelectasis,
however, deviates the trachea toward the affected
Technique (Figures 14-15 and 14-16)
side, that is, the left.
Two methods can be used. The first technique is one
in which the therapist uses the palmar surface of one
CASE STUDIES
or both hands. The second method involves the use of
Case Study One
the ulnar border of one hand. With both techniques,
the sequence is, again, cephalocaudal and side to A 30-year-old man with cystic fibrosis shows symp
side. In either method, the next step is to ask that the toms of a one-week history of increased sputum pro
patient speak a predetermined phrase. The two most duction, loss of appetite, fatigue, and 3-lb. weight
commonly used are "99" or "one, two, three." A light loss. 'The results of the initial chest examination are
but firm touch is recommended. as follows:
Inspection: Forward head, kyphotic posture,
increased anteroposterior diameter, appears thin
Tracheal Deviation (Figure 14-17)
and fatigued, no dyspnea observed, effective wet
The trachea's midline position can be examined ante
cough
riorly. The PT places an index finger in the medial
Copyrighted Material
226 PART II Cardiopulmonary Assessment
:/"1\" , i '
'
f!
"""- "'\
::--...
\ '.
-II . ..:--_
, :
'
'"
1J;
FIGURE 14-17
Technique for determining the position of the trachea.
(With permission from Swartz MH: TextboQk of physical
diagnoses-history and examination. ed 2. Philadelphia,
1994, WB Saunders.)
FIGURE 14-16
Technique for evaluating tactile fremitus, method two.
(With permission from Swartz MH: Textbook of physical
diagnoses-history and examination, ed 2. Philadelphia,
1994, WB Saunders.)
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14 Clinical Assessment of the Cardiopulmonary System 227
Auscultation: Decreased breath sounds with Mediate percussion: dull over affected area
scattered crackles throughout all lung fields, Palpation: trachea midline, markedly decreased
especially over right middle and lower chest CWE on right side
Palpation: Limited chest wall excursion (CWE),
especially laterally Case Study Three
Mediate percussion: Dull over right middle and A 72-year-old woman shows symptoms of persistent
lower chest, especially laterally fevers, left chest wall discomfort, and history of fall I
week ago. CT scan shows loculated pleural effusion
Case Study Two on the left. Left chest tube is inserted for drainage;
working diagnosis is empyema. Patient is nonsmoker,
An ll-year-old girl is admitted to Pediatrics with a 4-
Inspection: RR 30; l:E ratio I:2; epidural
day history of recurrent fevers, shortness of breath,
==
and lethargy. CXR showed an RML pneumonia. catheter for pain control
Inspection: tachypnea; respiratory rate (RR) of 44; Auscultation: Absent breath sounds halfway up
Ratio of inspiration to expiration (I:E ratio == I: I; left lower lateral chest wall
weak, shallow cough Mediate percussion: flat over left lower lateral
chest, ego ph any also present Palpation: trachea deviated to right, decreased
TABLE 14-1
Adapted with permission from Swartz, MH: Textbook ofphysical diag/Uises-history and examirulliOI1, ed 2. Philadelphia, 1994, WB Saunders.
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228 PART II Cardiopulmonary Assessment
eWE on left, range of motion of left shoulder joint 7. Which components of the chest physical examina
limited in flexion and abduction at about 90 tion a physical therapist include in the initial
nP<Y,.p,,>< maximum assessment of a geriatric with a recent left
See Table 14-1 for a differentiation of Ul<11411U:>C;' total hio renlacement aud a history of COPD?
References
SUMMARY Chemiak. R.M., & Cherniak, L. ([983). Respirmiorl in heailh and
disease. (3rd ed.). Philadelphia: WB Saunders.
As demonstrated in the case each element of
Fraser, KG., Pare lA., Pare, P.O. Frazer, R. S .. & Genereux, G.P.:
the chest physical examination contributes to the phys (1988). Diagnosis of diseases ill the chest. Philadelphia: WB
ical therapist solving the of the individual pa Saunders.
tient. It is through "putting all the together that George, R.B., Light, R.W. Matthay, M.A. & Matthay, RA ( l990).
Describe the sequence for auscultation of lung Seidel, RM., Ball, J.W., Dains, J.E., & Benedict, G.W. (1995).
Mosby's guide 10 physical examinatioll (3rd ed.). Boston: Mosby.
sounds.
Swartz, M.H. (1994). Textbook of physical diagnoses-llIslOry and
2. State the difference between oerioheral and cen
examination (2nd ed). PhiJadeJphia: WB Saunders.
tral cyanosis. Tilkian, A.G., & Conover, M.D. (1993). Understanding heart
3. How are normal bronchial breath sounds different sounds and murmurs (3rd ed.). Philadelphia: WB Saunders.
from abnomUlI bronchial breath sounds? Wilkins, R.I., Hodgkin, J.E., & Lopez, B. (1988). Lung sounds. Sl.
Louis: Mosby.
4. Name two causes for a oathollOl?:lC
Wilkins, et al: Lung sound nomencla ture survey, C hest
5. Name two causes for decreased breath sounds.
98(4)886-889,1990.
6. Formulate a plan for evaluation of a patient with Willerson, J.T., & Cohn, J.N. ([995). Cardiovascular medicine.
an acute Right Lower Lobe Pneumonia. New York: Churchill Livingstone.
Copyrighted Material
Monitoring Systems
in the Intensive Care Unit
Elizabeth Dean
Hemodynamic status
INTRODUCTION
may differ among intensive care units, the principles
The primary goal of the intensive care unit (ICU) are similar and relate either directly or indirectly to the
team is the achievement of stable cardiopulmonary foremost goal of optimizing oxygen transport.
function and optimal oxygen transport. This chapter Cardiopulmonary status is often jeopardized with
presents an introduction to monitoring systems used the ICU patient by fluid and electrolyte disturbances
in the evaluation of cardiopulmonary status in the and acid-base imbalance. Regulation of these systems
ICU and describes some related elements of car and the clinical implications of imbalance are de
diopulmonary regulation that are relevant to assess scribed first with special reference to the JCU patient.
ment and treatment in physical therapy. The principles of monitoring systems used in assess
ICUs are becoming more specialized. In major hos ing cardiopulmonary sufficiency are presented in
pital centers, units are often exclusively designed and cluding the electrocardiogram (ECG) monitor, moni
staffed for the management of specific types of condi tors related to left- and right-sided heart function
tions e.g., medical, surgical, trauma, bums, and coro utilizing arterial and venous lines, and the intracranial
nary and neonatal care. Although monitoring priorities pressure (ICP) monitor. The intraaortic counter pulsa
229
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230 PART II Cardiopulmonary Assessment
FIGURE 15-1
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15 Monitoring Systems in the Intensive Care Unit 231
FIGURE 15-2
A and B, Closer bedside views of patients in an ICU. Note that with all the equipment, the patient is
almost lost. C, Note two IV lines with flow monitors. Blood infusion is also being received.
Continued.
Moderate to severe fluid imbalance can be re with fluid overload. Normally, the jugular pulse is
flected in the systemic blood pressure and jugular ve not visible 2 em above the sternal angle when the in
nous pressure (CVP). Elevated blood pressure can be dividual sits at a 45-degree angle. If the jugular pulse
indicative of fluid overload, but an intravascular fluid is noted, this can be a sign of fluid overload.
deficit of 15% to 25% must develop before blood Fluid replacement is based on a detailed assess
pressure drops. The jugular vein becomes distended ment of the patient's needs. Whole blood is preferred
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232 PART II Cardiopulmonary Assessment
FIGURE 15-2-conl'd
D, Bedside oxygen and suction set-up. E, Close-up piped in O2 and suction units, F, Close-up IVs
and drip monitoring flow devices (IMEO). G, Note IABP, ventilator, IVs, organization of unit at
the head of the bed. ECG unit overhead, suctioning and airway care equipment at the right of the
patient and "Ambu" bag at bedside.
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IS Monitoring Systems in the Intensive Care Unit 233
FIGURE 15·3
A, Patient after open heart surgery. Note insert of Swan Ganz, CV tubing connection taped to left
chest. On ventilator with oral endotracheal tube, oral airway is in place. Note the nasogastric tube,
ECG leads, and dressing covers sternal split incision site. B, Patient after open heart surgery. Note
ECG leads. Patient is now weaned from ventilator and endou·acheal tube; pacemaker wires are held
intact at upper abdomen in syringe area. Patient has a11erial Li ne in right forearm; Swan Ganz, CVP
also removed. Patient is almost ready to leave ICU; he is receiving an aerosol treatment.
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234 PART II Cardiopulmonary Assessment
to replace blood loss. Plasma, albumin, and plasma complaints of headache, thirst, and nausea, as well as
volume expanders such as Dextran can be used to changes in dyspnea, skin turgor, and muscle strength.
substitute for blood loss and to help reestablish blood More objective assessment is based on fluid intake,
volume. Albumin and substances such as Dextran in output, and body weight. Fluid balance is so critical
crease plasma volume by increasing the osmotic pres to physical well-being and cardiopulmonary suffi
sure of the blood, hence the reabsorption of fluid ciency that fluid input and output records are rou
from the interstitial space. Low molecular weight tinely maintained at bedside. These records also in
Dextran has the added advantage of augmenting cap c l u d e f l u i d v o l u m e lost in w o u n d dra inage,
illary blood flow by decreasing blood viscosity, and gastrointestinal output, and fluids aspirated from any
is therefore particularly useful in treating shock. body cavity (e.g., abdomen and pleural space).
A patient's weight may increase by several pounds
before edema is apparent. The dependent areas mani
Clinical Picture
fest the first signs of fluid excess. Patients on bed rest
Excesses and deficits of fluids and electrolytes can be show sacral swelling; patients who can sit over the
determined on the basis of laboratory determinations bed or in a chair for prolonged periods tend to show
of serum levels of the specific electrolytes. Elec swelling of the feet and hands.
trolyte levels and hematocrit are decreased with fluid Decreased skin turgor can indicate fluid deficit.
excess (hemodilution) and increased with fluid loss Tenting of the skin over the anterior chest in response
(hemoconcentration). to pinching may suggest fluid depletion. Wrinkled,
Excess fluid can be managed by controlled fluid toneless skin is more common in younger patients.
intake, normal diuresis, and diuretic medications. Re Weight loss may be deceptive in the patient on IV
placement of fluid and electrolyte losses can be fluids, who can be expected to lose a pound a day.
achieved by oral intake, tube feeding, intravenous This sign should therefore not necessarily be inter
(IV) infusion, and parenteral hyperalimentation. preted as underhydration.
Assessment of fluid and electrolyte balance is The cardiopulmonary assessment can reveal
based on both subjective and objective findings changes in fluid balance. Lung sounds are valuable in
(Table 15-1). At the bedside, the PT must be alert to identifying fluid overload. Vesicular sounds may be-
TABLE 15-1
Head and neck Distended neck veins, facial edema Thirst, dlY mucous membranes
Extremities Dependent edema "pitting," discomfort from Muscle weakness, tingling, tetany
weight of bed covers
Skin Warm, moist, taut, cool feeling when edematous Dry, decreased turgor
Respiration Dyspnea, orthopnea, productive cough, moist Changes in rate and depth of breathing
breath sounds
Circulation Hypertension, jugular pulse visible at 45-degree Pulse rate irregularities. dysrhythmia, postural
sitting angle, atrial dysrhythmias hypotension, sinus tachycardia
Abdomen Increased girth, fluid wave Abdominal cramps
Modified from Phipps WJ, Long Be, Woods NF, editors: Medical-surgical nursing: concepts in clinical practice, cd 4, SI. Louis. 1991,
Mosby.
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15 Monitoring Systems in the Intensive Care Unit 235
come more bronchovesicular in quality. Crackles and collection system is shown in Figure 15-4. The
may increase in coarseness. In the presence of fluid removal of thick fluids such as blood and organized
retention involving the pleurae, breath sounds dimin exudates with chest tubes is often indicated to pre
ish to the bases. Dyspnea and orthopnea may also be vent entrapment and loculation. Chest tubes are com
symptomatic of fluid excess. monly inserted in the sixth intercostal space in the
An early sign of congestive heart failure (CHF) mid or posterior axillary line. Chest tubes inserted
with underlying fluid overload is an S3 gallop (Ken into the pleural space are used to evacuate air or exu
TUCK'-y) caused by rapid ventricular filling. date. Chest tubes can also be inserted into the medi
Vigilance by the PT is essential in all areas of astinum after open heart surgery, for example, to
practice and not only the ICU. Fluid imbalance is evacuate blood.
common in older people and in young children, thus Any collection system is designed to seal the
it needs to be watched for on the ward, in the home, drainage site from the atmosphere and offer minimal
and community. resistance to the drainage of fluid and gas. This is ac
complished by immersing the end of the collection
tube under water (Figure 15-4). This is referred to as
CHEST TUBE DRAINAGE AND FLUID
an underwater seal system. Additional reservoirs are
COLLECTION SYSTEMS
included to decrease the resistance to fluid leaving
Chest tubes are large catheters placed in the pleural the chest. This resistance is greater in a single reser
cavity to evacuate fluid and air, and to drain into a voir system in which the reservoir serves both as the
graduated collection reservoir at bedside (Phipps, collection receptacle and underwater seal. A third
Long, Woods, 1991). A typical chest tube drainage reservoir can be added to the system that is attached
FIGURE 15·4
A, Chest tube drainage. B, Anterior view, Mediastinal drains.
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236 PART II Cardiopulmonary Assessment
The amount of exudate collected in the reservoir is RESPIRA TORY ACIDOSIS METABOLIC ACIDOSIS
measured every several hours or more often if the pa
Hypercapnia Bicarbonate deficit
tient is losing considerable amounts of fluid or less
Hypoventilation Hyperventilation
than the amount predicted. This information is incor Headache Headache
porated into the overall fluid balance assessment. In Visual disturbances Mental dullness
addition, changes in the quantity and quality of exu Confusion Deep respirations
Drowsiness Stupor
date should be noted by the PT before, during, and
Coma Coma
after changes in position and therapeutic interventions.
Depressed tendon reflexes Hyperkalemia
Hyperkalemia Cardia dysrhythmias
Ventricular fibrillation (secondary to
ACID-BASE BALANCE (secondary to hyperkalemia)
hyperkalemia)
Control of acid-base balance in the body is achieved
by regulation of hydrogen ion concentration in the RESPIRATORY ALKALOSIS METABOLIC ALKALOSIS
body fluids (Guyton, 1991; Shapiro, Peruzzi, and
Hypocapnia Bicarbonate excess
Kozelowski-Templin, 1994). The pH of the body is Lightheadedness Depressed respirations
normally maintained within a range of 7.35 to 7.45, Numbness/tingling of digits Mental confusion
or slightly alkaline. When pH of the blood drops Tetany Dizziness
Convulsions Numhm:ss/tingling of
below 7.35, a state of acidosis exists; above 7.45, a
digits
state of alkalosis exists. Regulation of pH is vital be
Hypokalemia Muscle twitching
cause even slight deviations from the normal range Cardiac dysrhythmias Tetany
cause marked changes in the rate of cellular chemical (secondary to hypokalemia) Convulsions
reactions. A pH below 6.8 and above 8 are incompat Hypokalemia
Cardia dysrhythmias
ible with life.
(secondary to
Acid-base balance is controlled by several regula
hypokalemia)
tory buffer systems; primarily carbonic acid-bicarbon
ate, phosphate, and protein buffer systems. These sys
tems act very quickly to prevent minute-to-minute
changes in pH. In compensation, pH is returned to
normal primarily by altering the component not pri
marily affected. If the primary cause is respiratory, the ume, potassium excess (hyperkalemia) is associated
compensating mechanism is metabolic. If the primary with both respiratory and metabolic acidosis, and
cause is metabolic, the compensating mechanism is neuromuscular hyperexcitability is associated with
respiratory. The lungs compensate for metabolic prob both respiratory and metabolic alkalosis.
lems over hours, whereas the kidneys compensate for
respiratory problems over days (Chapter 9).
BLOOD GASES
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15 Monitoring Systems in the Intensive Care Unit 237
HYPOXEMIA
analyzed daily in the ICU. In cases where the pa
tient's condition is changing for better or worse over In health, age and body position are factors that re
a short period of time or a specific treatment re duce arterial oxygen tension (Oakes, 1988). Arterial
sponse is of interest, blood gases may be analyzed oxygen levels diminish with age as a result of reduc
several times daily. With an arterial line in place, tions in alveolar surface area, pulmonary capillary
frequent blood gas analysis ·is feasible and not trau blood volume and diffusing capacity. Normal PaOz
matic for the patient. Should the patient be anemic, levels in older people should exceed 110-0.5 age. In a
however, blood loss associated with repeated arter young adult, Paoz ranges from 90 to 100 mm Hg in
ial blood sampling can be detrimental. Thus re the upright seated position. In supine, this range is re
quests for arterial blood gas analysis need to be par duced to 85 to 95 mm Hg and in sleeping, to 70 to 85
ticularly stringcnt in anemic patients. mm Hg. These values are significant in that in older
Arterial saturation (Sao2) can be readily monitored people, smokers, and people with pathology, these po
noninvasively with a noninvasive pulse oximeter. sitional effects are accentuated.
The ear lobe or a finger is initially warmed by rub Hypoxemia refers to reduced oxygen tension in
bing before attachment of the oximeter. Within a cou the blood. Some common signs and symptoms of var
ple of minutes, the Sao2 can be directly read from the ious degrees of hypoxemia in adults appear in Table
monitor. Pulse oximetry is a useful adjunct for rou 15-3. Although the brain is protected by autoregula-
tine evaluation of the effectiveness of mechanical
ventilation, the effect of anesthesia and treatment re
sponse. Continuous estimation of Saoz is particularly TABLE 15-3
useful before, during, and after mobilization and ex
Signs and Symptoms of Hypoxemia
ercise, position changes, and other therapeutic inter
Paoz SIGNS AND SYMPTOMS
ventions. The Sao2 may appear to be reduced in pa
tients who are anemic, jaundiced, have heavily 80-100 mm Hg Normal
pigmented skin, or have reduced cardiac output. 60-80 mm Hg Moderate tachycardia, possible onset of
respirat ory distress
Mixed venous oxygen saturation (SV02) provides a
50-60 mm Hg Malaise
useful index of oxygen supply and utilization at the tis
Lightheadedness
sue level (Copel, and Stolarik, 1991). Svoz is highly Nausea
correlated to tissue oxygen extraction, and thus is a Vertigo
good index of the adequacy of oxygen transport. The Impaired judgment
Incoordination
Sv0:2 is particularly useful as a significant warning sign,
Restless
a guide to myocardial function, and has been used as a
Increased minute ventilation
tool to titrate positive end-expiratory pressure supp0l1. 35-50 mm Hg Marked confusion
NOImal values of SVD2 are 75%. SVD2 values less than Cardiac dysrhylhmias
60% or a drop of 10% for several minutes are cause for Labored respiration
25-35 m m Hg Cardiac an-est
concern. Excessive Svo2 values in excess of 80% are
Decreased renal blood flow
also cause for concern. High SV02 values may occur in
Decreased urine output
patients with left to right shunts, hyperoxia, hypother Lactic acidosis
mia, cyanide toxicity, sepsis, anesthesia, and drug-in Poor oxygenation
duced paralysis. Despite its general clinical usefulness, Lethargy
Maximal minute ventilation
SV02 is a nonspecific indicator of the adequacy of oxy
Loss of consciousness
gen transport, that is, of the balance between oxygen <25 mm Hg Decreased minute ventilation
supply and demand. Abnormal Svoz values do not indi (secondary to depression of
cate precisely where the problem lies; thus other hemo respiratory center)
dynamic variables need to be considered.
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238 PART II Cardiopulmonary Assessment
tory mechanisms, an arterial oxygen tension of 60 of nonpulmonary tissues is little altered. In the lung,
mm Hg produces signs of marked depression of the high concentrations of oxygen replace nitrogen in
central nervous system (NS) reflecting the extreme poorly ventilated regions. This results in collapse of
sensitivity of cerebral tissue to hypoxia. areas with reduced ventilation perfusion matching.
H y poxemia is compensated primarily by in Lung compliance is diminished.
creased cardiac output, improved perfusion of vital High concentrations of oxygen (inspired oxygen
organs, and polycythemia. Secondary mechanisms of fractions greater than 50%) directly injure bronchial
compensation include improved unloading of oxygen and parenchymal lung tissue. The toxic effect of oxy
as a result of tissue acidosis and anaerobic metabo gen is both time and concentration dependent. Very
lism, that is, rightward shift to the oxyhemoglobin high concentrations of oxygen can be tolerated for up
dissociation curve. to 48 hours. High concentrations of oxygen in combi
The progressive physiologic deterioration ob nation with positive pressure breathing can predis
served at decreasing arterial oxygen levels will occur pose the patient to oxygen toxicity. At concentrations
at higher oxygen levels if any of the major compen of inspired oxygen less than 50%, clinically de
sating mechanisms for hypoxemia is defective. Even tectable oxygen toxicity is unusual regardless of the
a mild drop in Pao2 for example, is poorly tolerated duration of oxygen therapy.
by the patient with reduced hemoglobin and impaired
cardiac output. Alternatively, the signs and symptoms
HYPOCAPNIA
of hypoxemia may appear at lower arterial oxygen
levels, (e.g., in patients with chronic airflow limita Acute reductions in arterial carbon dioxide levels
tion who have adapted to reduced Pao2 levels). (hypocapnia) results in alkalosis and diminished cere
bral blood flow secondary to cerebral vasoconstric
tion. The major consequences of abrupt lowering of
HYPEROXIA
Paco2 are altered peripheral and central nerve func
Mean tissue oxygen tensions rise less than 10 mm Hg tion. Mechanical ventilation may initially cause an
when pure oxygen is administered to a healthy sub abrupt decrease in arterial PC02 and lead to a Iife
ject under normal conditions. Therefore the function threatening situation. In addition to blood gas anaJy-
FIGURE 15-5
BCG oscilloscope, printout for BCG. Note defibrillator paddles and BP cuff on shelf.
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15 Systems in the Intensive Care Vnit 239
end tidal measurement is useful in that it chest to provide mal information regarding
provides an index of in rhythm and heart rate, and thereby ensure
close patient monitoring. The positive electrode is
positioned at the fourth intercostal space at the right
HYPERCAPNIA
sternal border. The electrode is at
CO2, the principal end product of metabolism, is a the first intercosta l space in the left midclavicular
relative benign gas. has a key role in ventilation line. The electrode used to electrical
and in in cerebral blood pH, interference is often at the first intercostal
and tone. Acute increases in space in the midclavicular line, the
capnia) depress level of consciousness ground electrode may be wherever conve
the effect of acidosis on the nervous nient. Other electrode placements may be required,
but slowly increases in for in with or in pa
relatively well-tolerated. A high is tients with chest burns. The electrode wires are usu
of alveolar which causes a reduction secured to the patient's gown.
in alveolar and arterial Some patients with se Problems with the monitor result from
vere chronic airflow obstruction have been rPT,r.rtp(,\ faulty electrical and move
to be able to lead relatively normal lives with ment artifact. A thickened baseline can be caused
in excess of 90 mm Hg if hypoxemia is countered Ie electrical interference. An erratic
with supplemental oxygen. Acute administration of often results from and movement. The
oxygen to with chronic disease, how cause of any must be explained and unto
ever, may be because it inteli'eres with the ward in electrical activity of the myocardium
hypoxic drive to breathe observed in these ruled out. It is a dangerous practice for the PT to turn
Acute enhances sympathetic stimula off the ECG alarm system during treatment.
an increase in cardiac and in pe Cardiac can be broadly
vascular resistance. These effects may help into t a c h dy s r h y th m i a s a n d b radydysrhythmias.
to offset the effect of excess ion on the car Tachydysrhythmias are subdivided into
diovascular system, allowing better tolerance of flow ular and subjunctional tachycardias. Bradydysrhyth
than with metabolic acidosis of a similar degree. mias are subdivided into sinus bradycardia, and those
At extreme levels of hypercapnia, muscle related to heart block and conduction abnormalities.
and seizures may be observed. Trends in Paco2 can The subjunctional or ventricular dys
be monitored end tidal CO2 measurements. rhythmias are Ventricular
dia and ventricular fibrillation are medical emergen
cies immediate and treatment.
MONITORING
The characteristic features of ECG
A channel ECG monitor with an oscilloscope, are illustrated in Chapter 11. PTs
strip recorder, and digital heart rate display is in ICU management should be thoroughly famil
cally located above the at bedside in the lCU iar with ECG interpretation and the implications of
\5-5). The ECG can often be observed both the various dysrhythmias for management.
at bedside as well as at a central monitoring console, For further elaboration of ECG application and inter
where the ECGs of all patients monitored can pretation refer to Andreoli, Fowkes, and Wal
be observed lace ( 1991), Dubin (1989), and Fisher (1981).
The ECG monitor allows for continuous surveil
lance of the of Low and
Clinical Picture
heart rates are determined below and above
which the alarm will be For routine moni The clinical associated with dysrhythmic ac
in the coronary care unit, a modified chest lead tivity of the heart on the nature of the dys
is often used. Three electrodes are positioned on the rhythmia, the age and condition of the patient, and
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240 PART II Cardiopulmonary Assessment
TABLE 15·4
I. Tachycardias
A. Supraventricular No symptoms May precipitate
tachycardia Abrupt onset palpitations, light-headness congestive heart failure, acute
nausea, fatigue coronary insufficiency, myocardial
infarction, pulmonary edema
1. Sinus tachycardia Awareness of the heart on exertion Secondary to some precipitating
or with anxiety factor, e.g., fever, electrolyte
imbalance, anemia, blood and fluid
loss, infection, persistent hypoxemia
in COPD, acute MI, congestive
heart failure, thyrotoxicosis
2. Paroxysmal atrial Prevalent, sudden onset, precipitated by Common supraventricular
tachycardia (PAT) coffee, smoking, and exhaustion tachycardia
Spontaneous onset of regular
palpitations that can last for several
hours
May be obscured by myocardial
insufficiency and CHF in older
patients
Increased anxiety and report
of fatigue
3. Atrial flutter Rare Rapid regular-irregular rate
May be difficult to distinguish from PAT Suggests block at AV node
May be precipitated by alcohol, smoking, Atrial flutter waves in jugular venous
physical and emotional strain pulse
4. Atrial fibrillation Rare, occasionally with alcohol excess Usually secondary to a variety
in the young of cardiac disorders
5. Paroxysmal atrial Rare Common arrhythmia seen with
tachycardia with block digitalis toxicity
B. Subjunctional Rare Usually related to MI, pulmonary
embolus, severe CHF
Often unconscious, cyanotic,
ineffective pulse, blood pressure
and respiration
I. Ventricular tachycardia Rare Predisposed to ventricular fibrillation
2. Ventricular fibrillation Rare Ineffective cardiac Ol tpUt,
unconscious, dusky, cardiac
arrest threatens
II. Bradycardias
A. Sinus bradycardia Physiologic in very fit young adults In older patients may suggest sinus
node and conduction system
pathology; can produce syncope or
congc:-;tive heart failure
B. Heart block Rare Hypotension, dizziness, Iight
headedness, syncope
In chronic block with sustained
bradycardia, congestive heart failure
may be more frequent
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15 Monitoring Systems in the Intensive Care Unit 241
TABLE 15-4
specifically the absence or presence of underlying be measured directly from this line. A digital moni
heart disease. Distinguishing clinical features of com tor displays systolic and diastolic blood pressures
mon atrial and ventricular dysrhythmias are outlined above the patient at bedside. High and low blood
in Table IS-4. pressure levels are set, above and below which the
The subjunctional or ventlicular dysrhythmias are alarm will sound. Blood gas analysis can be per
typically associated with an extremely ill individual. formed routinely with an intraarterial line in place
Cyanosis and duskiness of the mucosal linings and pe without repeated puncturing of a blood vessel (Fig
riphery may be apparent. The patient is unresponsive, ure IS-6).
the pulse if ineffective, and spontaneous respirations
are likely absent. Defibrillation is initiated to restore
Pulmonary Artery Balloon Flotation Catheter
an effective, more normal rhythm. The high incidence
(Swan Ganz Catheter)
of myocardial conduction ilTegularities warrants a de
fibrillator being present at all times in the lCU for The pulmonary artery balloon floatation catheter or
rapid implementation of this commOn cardioversion Swan Ganz catheter is designed to provide an accu
procedure by the medical personnel. Ventricular dys rate and convenient means of hemodynamic assess
rhythmias may be tolerated better if ventricular rate is ment in the lCU (Buchbinder, and Ganz, 1976; For
low, thereby improving cardiac output. Even in this rester, Diamond, McHugh, and Swan, 1971; Swan,
circumstance, however, these dysrhythmias still pre 1975). The catheter is usually inserted into the inter
sent an emergency. nal jugular vein, the subclavian vein, or a large pe
The ECG of a patient with a pacemaker will re ripheral arm vein and directed by the flow of blood
flect either an imposed fixed or intermittent rhythm into the right ventricle and pulmonary artery (see
and rate depending on whether a fixed rate or demand Figure IS-3A (arrow), p. 233). The catheter is se
pacemaker has been inserted. curely taped to the patient's anTI, which is splinted
with an arm board to prevent dislodging. The proce
dure is generally associated with little risk and dis
Intra-Arterial Lines
comfort. Some of the complications that have been
An arterial line is established by direct arterial punc associated with pulmonary artery catheterization,
ture, usually of the radial artery. Blood pressure can however, include infection, venous thrombosis, my
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242 PART II Cardiopulmonary Assessment
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15 Monitoring Systems in the Intensive Care Unit 243
Pulmonary Artery
Aorta
Left Ventricle
Right Ventricle
FIGURE 15·7
Normal cardiac pressures in each heart chamber.
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244 PART II Cardiopulmonary Assessment
unreliable; therefore end diastolic PAP and PA WP into the femoral artery. To maintain proper placement
are used as the principal indicators of cardiopul and good circulation, the leg must be extended. The
monary sufficiency in patients in failure and shock. presence of an intraaortic balloon must be taken into
consideration whenever the patient is being treated
and positioned. Inflation and deflation of the balloon
INTRAAORTIC BALLOON
with helium is correlated with the ECG. The intraaor
COUNTER PULSATION (IABP)
tic balloon is deflated during venlricular systole and
Intraaortic balloon counter pulsation (Figure 15-8) assists the emptying of the aorta. Stroke volume is
provides mechanical circulatory assistance with the potentiated, afterload is reduced (hence, ventricular
use of an intraaortic balloon. The balloon is inserted pressure), and myocardial oxygen delivery enhanced.
FIGURE 15-8
A, Patient near the window is receiving intraaortic balloon pump (lABP) support. B, Close-up of an IABP unit.
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15 Monitoring Systems in the Intensive Care Unit 245
The balloon is inflated during diastole, thereby neurons; progressive muscle weakness results. A con
restoring arterial pressure and coronary perfusion. tralateral weakened hand grasp, for example, may
Counterpulsation improves cardiac output, reduces progress to hemiparesis or hemiplegia. The Babinski
evidence of myocardial ischemia, and reduces ST sign, hyperreflexia, and rigidity are additional motor
segment elevation. lntraaortic balloon counterpulsa signs that provide evidence of decreasing motor func
tion is commonly used after open heart surgery, for tion as a result of upper motor neuron involvement.
CHF, medically refractive myocardial ischemia, ven Herniation can produce incoordinate respirations
tricular septal defects, and left main coronary stenosis that are correlated with the level of brainstern com
in patients who have shock. The intraaortic balloon pression. Cerebrate rigidity results from tentorial
pump provides protection for the myocardium in herniation of the upper brainstem. This results in
many instances until surgery can be pelformed. Limb blocking of the motor inhibitory fibers and the famil
ischemia, the most common complication, occurs in iar extended body posture. Seizures may be present.
10% to 15% of patients. These neuromuscular changes may further com
Left ventricular assist devices are used postopera pound existing cardiopulmonary complications in
tively in patients following open heart surgery who the ICU patient.
have developed cardiogenic shock and are unrespon Clinically, increased rcp is best detected by altered
sive to conventional management. These devices take consciousness, blood pressure, pulse, pupillary re
over the pumping action of the left ventricle and de sponses, movement, temperature, and respiration
crease myocardial workload and oxygen consump (Luce, 1985). The rcp monitor provides direct mea
tion. These types of assistive devices may have con surement of ICP. A hollow screw is positioned through
siderable potential in the management of refractory the skull into the subarachnoid space. The screw is at
heart failure. tached to a Luer-Lok, which is connected to a trans
ducer and oscilloscope for continuous monitoring.
The prevention of further increase in rcp and a
MEASUREMENT OF INTRACRANIAL PRESSURE
corresponding reduction in cerebral perfusion pressure
rncreased intracranial pressure (ICP) resu Its from is a treatment priority. High ICP and low cerebral per
many neurological insults including head injury, hy fusion pressure are highly con-elated with brain injury.
poxic brain damage, or cerebral tumor, and may re Measures to reduce venous volume are maintained
quire surgery. rn the adult, the cranial vault is rigid until ICP has stabilized within normal range. Prudent
and noncompliant. rncreases in the volume of the cra body positioning is used to enhance venous drainage
nial contents result in an elevated ICP and decreased by elevating the bed 15 to 30 degrees and maintaining
cerebral perfusion pressure. the head above heart level. Neck flexion is avoided.
Changes in consciousness are the earliest and most Fluid intake and output are carefully monitored; the
sensitive indicators of increased rcp (Borozny, 1987; patient may need to be fluid restricted. The Valsalva
Luce, 1985). Altered consciousness reflects herniation maneuver is avoided, since intrathoracic pressure and
of the brainstem and compression of the midbrain. rcp may increase correspondingly.
Compression of the oculomotor nerve and the pupillo Normal range of ICP is 0 to \0 mm Hg for adults,
constrictor fibers results in abnormal pupillary reac and 0 to 5 mm Hg for patients under 6 years of age.
tions associated with brain damage. The ICP may reach 50 mm Hg in the normal brain;
The effect of rcp on blood pressure and pulse is typically, however, this pressure returns to baseline
variable. Blood pressure may be elevated secondary levels instantaneously. In patients with high levels of
to elevated rcp and hypoxia of the vasomotor cen rcp and low cerebral compliance, extra care must be
ter. A reflex decrease in pulse occurs as blood pres exercised during routine management and therapy.
sure rises. An ICP elicited by turning or suctioning up to 30 mm
Compression of upper motor neuron pathways in Hg may be acceptable provided the pressure drops
terrupts the transmission of impulses to lower motor immediately following removal of the pressure
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246 PART IJ Cardiopulmonary Assessment
potentiating stimulus. Patients may be mechanically bency. The selection of treatment and the assessment
hyperventilated to keep arterial PC02 at low levels, of treatment response must be based upon quantita
since hypercapnia dilates c e rebral v e s sels and tive evaluation of the parameters affecting oxygen
hypocapnia constricts them. transport and cardiopulmonary function. Meticulous
To establish whether a patient will tolerate a treat monitoring contributes substantially to more rational
ment that requires movement or body positioning, an management of the lCU patient (i.e., the optimization
indication of cerebral compliance is needed. This can of physical therapy efficacy, in addition to minimiz
be obtained by observing changes in ICP during rou ing deleterious treatment outcomes).
tine nursing procedures or by titrating small degrees
of movement or position change and observe the rate
REVIEW QUESTIONS
at which the ICP returns to baseline following the
challenge. Rapid return to baseline minimizes the risk 1. Explain the determinants of fluid and electrolyte
of reduced cerebral perfusion pressure secondary to balance, and factors that contribute to fluid ex
the increased lCP. A slow return to baseline or sus cesses and deficits.
tained elevation of rcp is consistent with poor cere 2. Describe the basis of acid and base balance.
bral compliance and indicates treatment should be 3. Describe the physiological effects of hypoxia
modified or possibly not performed at all depending and hypercapnia.
on the absolute level of the lCP. 4. Explain the physiologic basis of ECG monitoring
and common supraventricular and ventricular
dysrhythmias.
ELECTROENCEPHALOGRAM MONITOR
5. Explain (a) the physiologic basis of the pul
An electroencephalogram, or EEG, provides useful monary artery balloon floatation catheter, and (b)
information about gross cerebral functioning and what is represented by altered CYP, RAP (sys
changes in level of consciousness. A single-channel tolic and diastolic), PAP (systolic and diastolic),
EEG monitor can be readily used in the lCU to reveal and the PAOP.
evidence of posttraumatic epilepsy when the clinical 6. Describe the basis of intra aortic balloon counter
signs may be inhibited by muscle relaxants. An EEG pulsation.
assessment may also be of some benefit to the PT in 7. Describe intracranial pressure monitoring, its
assessing the effects of arousal, treatment and senso physiological basis and clinical implications.
rimotor stimulation on cerebral function.
References
SUMMARY
Andreoli. K. G., Fowkes. V. K.. Zipes. D. P .. & Wallace. A. G. (Eds.)
Monitoring cardiopulmonary function and oxygen (1991). Comprehensive cardilu: care (7th ed.). Sl. Louis: Mosby.
Barrdl. S. E. & Abbas. H. M. (1978). Monitoring during physio
transport is an essential component of the manage
therapy after open heart surgery. Physiotherapy. 64(9). 272-273.
ment of the patient in the lCU. Regulation of home
Borozny. M. L. (1987). Intracranial hypertensi()n: Implications for
ostasis is disrupted in disease or following medical the physiotherapist. Physiotherapy Cwwdu. 39. 360-366.
and surgical interventions. PTs working in the unit Buchbinder, N. . & Ganz, W. (1976). Hemodynamic monitoring:
require a thorough understanding of homeostatic reg Invasive techniques. Anesthesi% gy. 45(2). \46-\55.
Burkj. N. K.. & Albert. R. K.'(1983). Noninvasive monitoring of
ulation and monitoring of fluid and electrolyte bal
arterial blood gases. A report of the ACCP section on respira
ance, acid base balance, and blood gases. Physical
tory pathophysiology. Chest. 83(4).666-670.
therapy has an essential role in res tOling homeostasis Copel L. c.. & Stolarik. A. (1991). Continuous Sv02 monitoring.
in patients requiring intensive care, using conserva A research review. Dimensions of Cri/ica/ C a re Nursin!i. lO,
tive, noninvasive approaches, in addition to averting 202-209.
Cromwell, L.. Wei bell. F. l, & Pfeiffer. E A. (1980). Biomedical
the musculoskeletal, neuromuscular, and multisystem
ins/rumentarion and measuremen/s (2nd ed.). Englewood
complications associated with immobility and recum
Cliffs: Prentice-Hall.
Copyrighted Material
15 Monitoring Systems ill the Intensive Care Unit 247
DeGowin, E, L, & DeGowin, R L (1981), Bedside diagnostic ex Oakes, D, F. (1988), Clincfal practitioners pocket 10 respira
aminatioll (4th cd.). New York: Macmillan. lory care. Old Town: Health Educator Publications.
Dubin, D, (1989). Rapid illterprelatiotl of EKGs, (4th ed,), Tampa, Phipps, W. J., Long, B. & Woods, N. F. (Eds,). (1991). Med
Fl.: Cover. iced-surgical nursing: concepts and clinical practice (4th ed.).
Fisher, J, D, (1981). Role of electrophysiologic testing in the St Louis: Mosby,
nosis and treatment of patients with known and suspected Pmi, V. K, Carlson, R. W., Bander, J. J, & Wei!, M. H. (1980).
bradycardias and tachycardias. Progress in Cardiovascular Complications of vascular catheterization in the critically ill. A
Diseases, 24(1),25-90. prospective study. Critical Care Medicine. 8(9),495-499.
Folk-Lighty, M. (1984). Solving the puzzles of patients' lluid im Shapiro, B. A., Peruzzi, W. T., & Kozelowski-Templin, R. (1994).
balances. Nursing, 14(2),34--41, Clinical application of blood gases (5th SL Louis: Mosby.
Forrester, J. S., Diamond, G., McHugh, 1'. 1. (1971), Filling pres Snider, G. L. (1973). Interpretation of the arterial oxygen and car
sures in the right and left sides of the heart in acute myocardial bon dioxide partial pressures. A simplified approach for bed
infarction: A reappraisal of central-venous-pre5sure monitor side use. Chest, 63(5), 801-806.
ing. New Englimd Journ al of Medicine, 285(4), 190--[93, Swan,H. J, (1975), Second annual SCCM lecture. The role of he
Ganong, W. F. (1993), Review o.fmedical physiology, (16th modynamic monitoring in the management of the critically ill.
Los Altos: Lange :Vledical Publications Critical Care Medicine, 3(3),83-89,
Guyton, A. C. (l991). Textbook of medical physiology (8th ed.). Thomas, H. M., 3rd, Lefrak, S. S., irwin, R. S., Fritts, H. W., Jr , &
.
Copyrighted Material
PART III
Cardiopulmonary Physical
Therapy Interventions
Copyrighted Material
Optimizing Treatment Prescription:
Relating Treatment to the Underlying
Pathophysiology
Elizabeth Dean
251
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252 PART III Cardiopulmonary Physical Therapy Interventions
ment hierarchy is presented, with the premise that detailed understanding of the relevant anatomy and
physiologic function, including oxygen transport, is physiology, multisystem and integrative pathophysiol
optimal when humans are upright and moving. Apply ogy, the impact of medical, surgical, and nursing pro
ing a systematic physiologic approach to the analysis cedures, the effect of various laboratory tests and pro
of the patient's problems, with respect to deficits in the cedures, and the impact of pharmacological agents on
oxygen transport pathway, leads directly to the most cardiopulmonary function (see box above, at left).
efficacious treatments. Such an approach provides a For a given patient, the cardiopulmonary PT pre
basis for modifying or discontinuing treatment based scribes treatment by extracting the relevant information
on the use of appropriate treatment outcome measures. from the history, laboratory tests and investigative pro
cedures, and the assessment (see box above. at right).
Problems are prioritized based on the relative magni
WHAT IS THE PROBLEM?
tude of each one's effect on impairment of oxygen
Oxygen transport is determined by a multitude of fac transport. Once the mechanisms for the cardiopul
tors which affects different steps in the oxygen trans monary and cardiovascular dysfunction have been iden
port pathway (see Figure I-I, p. 4) (Chapter I). For tified, specific treatments are selected and prioritized.
treatment to be directed specifically to the underlying
problems, the physical therapist (PT) needs to consider
The Problem list
several levels of analysis of the deficits contributing to
impaired or threatened oxygen transport. To be profi
Impaired oxygen transport
cient in such analysis, the PT must have a thorough Two levels of problems need to be identified. namely,
knowledge of the multiple factors that contribute to ab functional and physiologic deficits. The functional
normal gas exchange. This knowledge base includes a deficits are those that affect the patient's ability to
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16 Optimizing Treatment Prescription: Relating Treatment to the Underlying Pathophysiology 253
Altered central nervous system (CNS) afferent input and control of breathing
Impaired efferent pathways
Pharmacologic depression
Substance abuse depression
Airways
Lungs
Blood
Bleeding abnormalities, altered body temperature (hypothermia, hyperthermia). fever, inflammation, hypermetabo
lism secondary to mediator systems
Altered body temperature related to integumentary disruption
Low hematocrit secondary to GI bleed (more prone to hypoxia)
Anemia
Thrombocytopenia
Dissemin ... ted intravascular coagulation
Abnorm... 1 clotting faclOrs (i,e" halance between clotting and not c1olling, sludging of blood)
Thromboelllboli
Bleeding disorders with liver disease; ...bnormal clotting factors
Continued,
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254 PART III Cardiopulmonary Physical Therapy Interventions
Examples of Deficits in and Threats to Steps ill the Oxygen Transport Pathway-cont'd
Gas Exchange
Alveolar collapse, atelectasis, intrapulmonary shunting or pulmonary edema, shallow breathing and tenacious mucus,
body position, consolidation and alveolar collapse, ventilation/perfusion mismatch, airway constriction, t1uid vol
ume excess, pleural effusions. breathing at low lung volumes. abdominal distension and guarding. ineffective air
way clearance, pulmonary microvascular thrombi and altered capillary permeability secondary to circulating medi
ators. closure of small airways secondary to dynamic airway compression. decreased functional residual capacity,
and intrapulmonary shunting, increased lung surface tension
Diffusion defects
Respiratory Muscles
Upper abdominal surgery. weakness, fatigue. neuromuscular discase. ileus related to gastric distension, mechanical
dysfunction
Myocardial Perfusion
Tachycardia
Heart
Decreased venous return and cardiac output, secondary to volume deficit, ascites, myocardial ischemia, hemorrhage,
and coagulopathies
Conduction defects
Mechanical defects
Abnomlal afterload
Blood Pressure
Volume deficit/bleeding
Alteration in peripheral tissue perfusion related to acute myocardial infarction. myocardial depression, maldistribu
tion of blood volume, and altered cellular metabolism
Volume excess
Tissue Perfusion
Atherosclerosis and thromboembolic events, decreased circulating blood volume. decreased circulating blood vol
ume, decreased vascular integrity. and int1ammatory process
Decreased cardiac output related to reduced venous return. impaired right ventricular function, dysrhythmias, in
creased afterload, and bradycardia
Thromhoembolism. vasoconstriction secondary to toxins. sepsis, etc., blood flow alterations and hypermetabolism
secondary to mediator systems
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16 Optimizing Treatment Prescription: Relating Treatment to the Underlying Pathophysiology 255
Apparent hypervolemia secondary to restricted mobility and recumbency (e.g., resulting from hemodynamic instability)
Renal failure
Water intoxication
Therapeutic volume expansion. acute myocardial infarction (MI) and acute renal failure. related to renal retention of
sodium and water and increased levels of aldosterone, renin, angiotensin II, and catecholamines
Fluid volume deficit related to volume losses during surgery and inadequate oral intake, blood loss, internal injuries
(e.g.. hematoma and third spacing phenomenon: hormonal imbalance; increased intestinal motility; vomiting; diar
rhea: tluid sequestration in tissues; nasogastric (NG) suction and diarrhea: hypovolemia; sepsis and shock; surface
capillary leak and fluid loss as in burns and excoriated wounds; tluid shifts)
Tissue Oxygenation
MultisysteJll organ failure with allered peripheral tissue perfusion and gas exchange at the cellular level
Infection
Pulmonary and nonpulmonaty infection increase the demands on the oxygen transport system
Cognition
Alleration in mental status secondary to inadequate cerebral perfusion with hypotension and cardiogenic shock
Anxiety and agitation relatcd to powerlessness and lack of knowledge, breathlessness, pharmacological paralysis, im
paired verbal community secondary to intubation, paralysis etc.
Psychosocial Factors
Pain response
Nutrition
Altered nutritional needs secondlllY to greater need than resting state (i.e.. increased caloric need and nutrients asso
ciated with illness, inability to ingest food, inability to absorb food)
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256 PART III Cardiopulmonary Physical Therapy Interventions
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16 Optimizing Treatment Prescription: Relating Treatment to the Underlying Pathophysiology 257
steps in the oxygen transport pathway that com Treatment directed at specific steps involved
pensate for impaired steps that may or may not Object to enhance the efficiency of all steps in the
be reversibly affected pathway
3. To maximize oxygen transport capacity to sus Augment medical management
tain maximal functional activity.
Coordinate with nursing management (e.g., in criti
And preventive treatment goals include: cal care)
I. To prevent cardiopulmonary dysfunction
Goals Directed at Specific Steps in the Oxygen
2. To prevent multisystem organ complications
Transport Pathway
and nonpulmonary infection that will lead to
Maximize air entry and alveolar ventilation (mini
further restricted movement and recumbency,
mize airflow resistance)
hence the potential for further deterioration
Maximize air distribution (optimize lung compli
3. To provide supportive palliative care.
ance and chest wall compliance)
The basis for clinical decision making in the man Reduce work of breathing (increased resistance, re
agement of the cardiopulmonary patient is to pair the duced or excessive compliance)
most efficacious treatments specificall y with im Reduce work of the heart (increased preload, con
paired or threatened steps in the oxygen transport traction. increased afterload)
pathway. In addition, the patient spends considerable Maximize efficiency of heart mechanics
time between treatments, thus optimal therapeutic ef Minimize electrocardiogram (ECG) irregularities
fect is dependent on the efficacy of "between treat (identify factors that contribute to irregularities;
ment" treatments (i.e., teaching the patient to carry anticipate problems)
out prescriptive treatment whenever possible and Optimize blood flow distribution
eliciting the assistance of the patient's family or Optimize oxygen extraction ratio
nursing staff).
Reduce excessive or unnecessary energy expenditure
When confined to hospital, many patients spend
Optimize carbon dioxide (C02) removal
considerable time recumbent and in restricted body
positions, turn and move less frequently, and are up Optimize blood volume
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258 PART III Cardiopulmonary Physical Therapy Interventions
Goal: To elicit an exercise stimulus that addresses one of the three effects on the various steps in the oxygen trans
port pathway, or some combination
A. Acute effects
B. Long-term effect
C. Preventative effects
Goal: To elicit a gravitational stimulus that simulates being upright and moving as much as possible i.e., adive. ac
tive assisted or passive
B. Cardiopulmonary effects on ventilation anti its distribution, pelfusion. ventilation. and perfusion matching
and gas exchange
Goal: To augment alveolar ventilation, to facilitate mucociliary transport. and to stimulate coughing
F. Incentive spirometry
Goal: To facilitate mucociliary clearance with the least effect on dynamic airway compression and adverse cardio
vascular effects
C. Modified coughing interventions with open glottis (e.g., forced expiratory technique, hulT)
Goal: To minimize the work of breathing. of the heart. and oxygen demand overall
B. Energy conservation, (i.e., balance of activity to rest, performing activities in an energy) efficient manner.
improved movement economy during activ:ty)
A. Active
B. Assisted active
C. Passive
Continued.
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16 Optimizing Treatment Prescription: Relating Treatment to the Underlying Pathophysiology 259
Goal: To facilitate airway clearam;e in conj unction with specific body positioning
A. Autogenic drainage
B. Manual percussion
IX. Suctioning
Goal: To fac ili tate the removal of airway secretions collected centrally
C. Tracheal tickle
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260 PART III Cardiopulmonary Physical Therapy Interventions
Antiintlammatories
WHAT IS THE COURSE OF TREATMENT? Mucolytics
Define parameters of treatment based on history, laboratory investigations, tests, and assessment
Treatment type
Duration
Frequency
Instruct patient in "between treatment" treatment, and if applicable the nurse. a family member. or both
Predict time course for optimal effects and course of treatment to determine treatment efficacy; modify as necess,u'y
In conjunction with other interventions (e.g., medical, surgical, nursing, respiratory therapy (weaning» oxygen sup-
plementation. sympathomimetic drugs, ADLs, balance with sleep and rest periods. peak of nutrition and feeds. peak
energy times. peak of drug potency and effects (e.g., pain, reduced sedation. reduced neuromuscular blockade)
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16 Optimizing Treatment Prescription: Relating Treatment to the Underlying Pathophysiology 261
Assessment and Treatment Outcome Measures Used in the Management of Deficits in Oxygen Transport
Pathway
Pulmonary Circulation
Airways
Pelfusion scan
Clinical assessment including auscultation
Pulmonary artery balloon t1oatation catheter to assess
Pullllonary function tests
central venous pressure, pulmonary artery pres
Arterial blood gases sures, wedge pressure
Chest X-ray
Heart
Histamine challenge exercise tests
Clinical assessment including percussion. palpation.
Lungs and auscultation
Clinical assessment including inspection. percussion. Inspection and clinical observation tests including
palpation and auscultation jugular venous distension test
Pulmonary function tests Heart rate, systolic and diastolic blood pressures, and
rate pressure product
Ventilation and perfusion scans
ECG
Diffusion capacity test
Hemodynamic studies to assess cardiac output, stroke
Arterial blood gases
volume, cardiac distensibility. and ejection fraction
Chest X-my
Ultrasound procedures to examine mechanical integrity
lmmunulogical status
Scans
Respiratory muscle assessment
Coordination of electromechanical behavior of heart
Assessment of the structure and integrity of chest
Coronary artery perfusion studies
wall
Stress test
Lung water studies
Hemodynamic monitoring including central venous
Blood pressure, pulmonary artery pressures and wedge
Circulating blood volume and cardiac output pressure
Cun/iIlLted.
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262 PART III Cardiopulmonary Physical Therapy Interventions
Assessment and Treatment Outcome Measures Used in the Management of Deficits ill Oxygen Transport
Pathway-colll'd
Arterial and venous lab studies and investigations Adequacy and efficiency of aJterial ,Uld venous tissue
ment based on the patient's treatment response. The sential that these measures have certain characteris
PT also bases the decision when to discontinue a tics. For example, measurements must be objective
given treatment as well as what overall cardiopul and their procedures standardized to maximize test va
monary physical therapy to employ, based on treat lidity and reliability. Although PTs specialize in non
ment response and outcome. invasive assessment procedures as well as treatments,
Measures to assess treatment response and out noninvasive measures are prone to imprecision, and
come are selected that reflect (J) the status of oxygen hence measurement error and unreliability. It is there
transport overall, and (2) the integrity of the step or fore essential that assessment measurements are per
steps in the oxygen transport pathway that were iden formed in a systematic manner according to measure
tified as being the primary problems contributing to m e n t guid elines to maximize their quality and
cardiopulmonary or cardiovascular dysfunction in the usefulness in guiding and directing treatment (Chapter
original assessment (see box on pp. 261-262.) (see 6). Assessment measurements always precede any
Part II of this text). Cardiopulmonary dysfunction is treatment to ensure that treatment is appropriate, that
determined based on the history, assessment and lab is, the baseline measurements. Measurements during
oratory investigations, such as, pulmonary function treatment provides information about the patient's re
testing, breathing pattern, cardiac function testing, sponses, both beneficial and detrimental. This feed
fluid balance and renal function, anerial blood gases, back determines the parameters of treatment, and
arterial saturation, vital signs, and hemodynamic whether the treatment should be modified in some
variables, including heart rate and ECG, blood pres way, or possibly discontinued. The overall treatment
sure, and rate pressure product. Subjective repOits are response is established by further monitoring and as
also clinically relevant, such as subjective ratings of sessment at the termination of treatment, and often at
perceived exertion, breathlessness, angina, and fa peliodic intervals posttreatment so that delayed effects
tigue. These same measures are used to detect im can be monitored. Frequent and periodic measure
proved oxygen transport and gas exchange. ments over time are refelTed to as serial measurements
Considering that clinical decision making is based and provide useful trend data. The pre- and posttreat
largely on the results of tests and measures, it is es ment responses and any noteworthy responses during
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16 Optimizing Treatment Prescription: Relating Treatment to the Underlying Pathophysiology 263
making process involves diagnosis, that is, specific cational sellings. New York: Pergamon Press.
Cutler, P. (1985). Problem solving in clinical medicine. (2nd ed.).
analysis of the patient's problems in relation to the
Baltimore: Williams and Wilkins.
physiology and underling pathophysiology, the contri
Dantzker, D.R. (1991). Cardiopulmonary critical care. (2nd ed.).
bution of restricted mobility and recumbency, and ex Philadelphia: WB Saunders.
trinsic and intrinsic factors. Based on this analysis, Dean, E. (1994). Oxygen transport: A physiologically-based con
treatment interventions and their parameters are pre ceptual framework for the practice of cardiopulmonary physio
therapy. Physiotherapy, 80, 347-355.
sClibed that have the greatest physiological and scien
Epstein, C.D.,& Henning R.1. (1993). Oxygen transpOlt variables
tific justification. Treatments and their prescription pa
,
Copyrighted Material
Mobilization and Exercise
Elizabeth Dean
INTRODUCTION
port in a large proportion of patients. The sequelae of
The first purpose of this chapter is to define the terms immobility and recumbency adversely affect all
mobilization and exercise and then to review the basis steps in the oxygen transport pathway. An under
for prescribing mobilization and exercise as primary standing of the effects of immobility and reduced ex
physical therapy treatment interventions to optimize ercise stress on normal human physiological function
oxygen transport. The three distinct objectives of mo provides the rationale for prescribing exercise for its
bilization and exercise for the purpose of maximizing preventive effects.
oxygen transport are described. These include the ex
ploitation of their acute, long-term, and preventive ef
DEFINITIONS
fects. Mobilization or exercise can be prescribed
specifically to elicit whjch of these effects is indicated. Mobilization is defined as the therapeutic and pre
The second purpose of this chapter is to review scriptive application of low-intensity exercise in the
the negative effects of immobility and reduced exer management of cardiopulmonary dysfunction usually
cise stress on multisystem function with special at in acutely ill patients. Primarily, the goal of mobiliza
tention to cardiopulmonary and cardiovascular func tion is to exploit the acute effects of exercise to opti
tion. Immobility and recumbency are major factors mize oxygen transport. Even a relatively low-inten
contributing to impaired or threatened oxygen trans- sity mobilization stimulus can impose considerable
265
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266 PART III Cardiopulmonary Physical Therapy Interventions
metabolic demand on the patient with cardiopul the submaximal exercise test have been less well-de
monary compromise. In addition, mobilization is per fined (Dean and Ross, 1992a; Dean and Ross, 1993;
formed in the upright position, that is the physiologic Shepherd et aI, 1968).
position (Chapter 18), whcnever possible, to optimize The prescription of mobilization and exercise to
the effects of being upright on central and peripheral optimize oxygen transport in the patient with acute
hemodynamics and fluid shifts. Thus mobilization is cardiopulmonary dysfunction has been a relatively
prescribed to elicit both a gravitational stimulus and neglected area of research compared with exercise
an exercise stimulus. prescription in the management of chronic cardiopul
Exercise is the term used to describe the therapeu monary dysfunction. This is surprising given that
tic and prescriptive application of exercise in the "early mobilization" is a key component of car
management of subacute and chronic cardiopul diopulmonary physical therapy in the management of
monary and cardiovascular dysfunction. Primarily, acutely ill patients. Orlava (1959) was the first to re
the goal of exercise is to exploit the cumulative ef port the beneficial application of mobilization in the
fects of and adaptation to long-term exercise and management of acute cardiopulmonary compromise,
thereby optimize the function of all steps in the oxy specifically, bronchopulmonary pneumonia. The
gen transport pathway. physiologic literature supports an unequivocal role
In addition, mobilization and exercise can be pre for therapeutic mobilization to maximize oxygen
scribed for their preventive effects. In this case, the transport in patients with acute cardiopulmonary dys
parameters of the prescription focus on exploiting function (Dean and Ross, 1992b). Despite this con
their multisystemic effects as well as their cardiopul clusive body of literature, Orlava's work has not been
monary and cardiovascular effects. extended significantly in the literature since her work
was published more than 35 years ago.
Unlike exercise prescription for the patient with
BASES FOR THE PRESCRIPTION
chronic cardiopulmonary and cardiovascular dys
OF EXERCISE STRESS
function, the acute patient cannot be exercise tested
The prescription of exercise is fundamental in the in the conventional manner given the risks of an un
management of primary and secondary cardiopul toward exercise response. Given the profound and di
monary and cardiovascular dysfunction. Exercise sci rect effects of mobilization and exercise on car
ence has advanced exponentially over the past 30 diopulmonary and cardiovascular function, it is
years and is a primary basis for cardiopulmonary essential that the physical therapist be able to identify
physical therapy. Guidelines have been developed for the specific effects of exercise required and define the
prescribing exercise to maximize functional work ca optimal therapeutic stimulus, ie, the stimulus that
pacity or aerobic capacity for healthy persons and in yields the maximal benefit to oxygen transport with
dividuals with chronic heart and lung disease (Ameri the least risk.
can College of Sports Medicine, 1994; Belman and Acute and chronic cardiopulmonary and cardio
Wasserman, 1981; Blair, Painter, Pate, Smith and vascular pathology have the additional problem of
Taylor, 1988; Froelicher, 1987; Hasson, 1994; Irwin compromising functional capacity in two important
and Tecklin, 1985; Wasserman and Whipp, 1975; ways. First, in acute illness, the patient tends to be re
Zadai, 1992). Exercise training is based on the find cumbent in bed a greater propOition of time, and sec
ings of a maximum graded exercise test. Submaximal ond, in both acute and chronic illnesses, the physical
exercise testing is often indicated for patients with se activity of the patient is reduced. Recumbency and
verely impaired functional work capacity because of immobility have physiologically distinct effects on
the inherent risks associated with maximal testing oxygen transport and are the primary determinants of
(Compton, Eisenman, and Henderson, 1989). Guide bed rest deconditioning (Chase, Grave, and Rowell,
lines for submaximal exercise testing, test interpreta 1966; Convertino, Hung, Goldwater, and DeBusk,
tion and prescription of exercise, however, based on 1982; Winslow, 1985). Thus dysfunction of oxygen
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17 Mobilization and Exercise 267
transport is further exacerbated in patients by the ad tions to remediate cardiopulmonary dysfunction, and
ditional factors of recumbency and immobility. The their effects exploited first.
impact of these factors is further exacerbated in
smokers, the young, older adults, obese individuals,
OXYGEN TRANSPORT AND METABOUC
and patients who are mechanically ventilated.
DEMAND IN PATIENTS
Even though the prescription of mobilization and
exercise for their acute effects ,is distinct from that for In health, when individuals have optimal physiologi
its long-term effects, the efficacy of the acute exer cal reserve, both the acute and long-term responses to
cise stimuli needs to be considered in terms of opti an exercise stimulus can be predicted. Specifically,
mizing long-term benefit to oxygen transport as well minute ventilation (vE) and cardiac output (CO),
as the short-term acute effects. Both acute and long hence oxygen delivery (002), increase commensu
term exercise needs to be prescribed specifically for a rate with work rate and oxygen demand.
given patient given the mechanisms of their underly In patients, whose oxygen transport capacity is re
ing pathology (American College of Sports Medicine, duced or threatened, mobilization and exercise con
1994). The prescription parameters should include stitute a significant additional metabolic demand that
(I) the type or types of mobilization or exercise, is superimposed on various other factors that con
I (2) specific intensity, (3) duration, and (4) frequency. tribute to increased metabolic cost (see box on page
These parameters are defined for each type of ex 268). Hospitalized patients tend to be hypermeta
ercise being prescribed. In addition, (5) the course of bolic. In addition to their basal metabolic demands,
the prescription, that is the time over which the pre their energy demands are increased secondary to such
scription is designed to produce its maximum benefit, factors as an increased body temperature, healing and
and (6) the means of progression of the prescription repair processes, increased work of breathing and of
are defined. the heart, and in response to routine interventions and
Exercise has been reported to have beneficial ef procedures including cardiopulmonary physical ther
fects in the management of a multitude of conditions. apy. The goal, therefore, in prescribing mobilization
Its benefits range from enhancing all steps in the oxy and exercise, is to ensure a safety margin wherein the
gen transport pathway to other peripheral and central patient's demand for oxygen does not exceed the
effects related to virtually every other organ system. available supply or delivery. In most situations, this
The preventive effects of exercise are central to would be indicated clinically by worsening of the pa
patient care across all conditions and physical therapy tient's oxygen transport objectively and subjectively.
specialties. Exercise is advocated preventively to Of the physical therapy related interventions, mobi
avoid the deleterious effects of immobility and to lization, exercise, body positioning, arousal, breathing
provide optimal systemic health protection secondary control maneuvers, coughing, postural drainage, man
to cardiopulmonary conditioning. ual techniques, bagging, suctioning and range-of-mo
Mobilization and exercise are the physical thera tion (ROM) exercises can significantly increase oxy
pist's (PT's) "drug" with definable indications, con gen consumption and overall metabolic demand
traindications, and side effects for each patient. The (Dean, Murphy, Parrent, and Rousseau, 1995; Weiss
prescriptive parameters are determined by the effects mann, Kemper, Darvask, Askanazi, Hyman, and Kin
needed to address the patient's underlying problems ney, 1984). Therefore, the capacity of the oxygen
directly, whenever possible. Mobilization and exer transport system to meet the patient's metabolic de
cise constitute the most potent and direct interven mands needs to be established in the physical therapy
tions affecting oxygen transport that are available to assessment. Can the oxygen transport system support
the PT in that, unlike other cardiopulmonary physical the patient's metabolic demands? If so, what reserve
therapy interventions, they affect all steps in the oxy capacity is available to support a mobilization or exer
gen transport pathway. Thus they need to be pre cise stimulus? The exercise stimulus is designed to ex
scribed specifically as primary treatment interven ploit the potential of the reserve capacity. Establishing
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268 PART III Cardiopulmonary Physical Therapy Interventions
Factors That Contribute to Increased Metabolic Demand and Oxygen Consumption in Patient Populations
Pathophysiological Factors
Fever (e.g., secondary to an infectious agent or inflammation, surgery, multiple trauma, severe illness)
Thermoregulatory challenges (i.e., too hot or too cold, altered ambient temperature and humidity)
Interventions
Body positioning
Pharmacologic agents
Psychosocial Factors
Anxiety
Discomf0l1
Pain
Agitation
Miscellaneous
Noises
the availability of that reserve is essential to optimize cedures need to be applied in the management of pa
the efficacy of the therapeutic exercise stimulus, that tients with cardiopulmonary and cardiovascular dys
is, neither subthreshold or suprathreshold. function in situations in which agitation, anxiety and
Metabolic demand and oxygen uptake are deter pain contribute significantly to increased oxygen de
mined by multiple factors. In patients, the effect of mand. This is especially true in intensive care, where
arousal, anxiety, pain, and noxious stimulation, in ad oxygen transport is compromised or threatened in
dition to the hypermetabolic demands of recovery, most patients (see Chapters 32 and 33).
contribute significantly to the energy cost and de
mand on the oxygen transport system. Thus relaxing
CElLULAR ENERGETICS IN RESPONSE
and calming patients is a central component of car
TO MOBILIZATION AND EXERCISE
diopulmonary physical therapy as these interventions
can minimize oxygen demand. Although relaxation, The cardiopulmonary unit supports oxygen transport
often coupled with analgesia is central to physical and cellular respiration (Weber, Janicko, Shroff, and
therapy management in other settings, relaxation pro Likoff, 1983). Oxygen is continually being Llsed by
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17 Mobilization and Exercise 269
every cell in the body for oxidative phosphorylation layed rather than eliminated. In disease states, anaer
and the synthesis of adenosine triphosphate (ATP). obic metabolism occurs when a patient's oxygen
The splitting of a phosphate bond from ATP to form transport system cannot meet the metabolic demand
adenosine diphosphate yields a considerable amount required, e.g., patients with sepsis and multisystem
of energy for metabolism. The e nergy for this organ failure. Serum lactate levels are significantly
process comes from the reduction of hydrogen in the elevated in these patients, resulting in metabolic aci
formation of water and carbon dioxide, which is the dosis, which is extremely unfavorable to the mainte
end products of the respiratory or electron transfer nance of homeostasis.
chain. These metabolic processes which comprise During exercise, the cellular P02 is lower than the
oxidative phosphorylation, take place in the mito surrounding interstitial fluid P02. Oxygen diffuses
chondria of the cells (Chapter I). rapidly through cell membranes. At the onset of
The balance of oxygen consumption to delivery physical exercise, the increased metabolic demand of
is precisely regulated to ensure that there is not the muscle and supporting tissues increases the oxy
only an adequate supply of oxygen, but also that gen diffusion gradient. Feedback mechanisms are
under normal resting conditions approximately four triggered to increase oxygen delivery, which de
times as much oxygen is delivered to the tissues as pends primarily on arterial oxygen content and car
is used. This safety margin permits the immediate diac output. The first line of defense is the response
availability of oxygen when the system is perturbed to an increase in pericellular pH. The concentration
by physical, gravitational, and mental challenges of carbon dioxide is increased which, as a result of
(see Chapter I). the decrease in pH, facilitates the dissociation of
Anaerobic metabolism occurs during all out short oxygen from hemoglobin, that is, it shifts the oxyhe
sprint type activities, e.g., hockey, soccer and volley moglobin dissociation curve to the right. The cardiac
ball. Although PTs tend to focus on aerobic rather than output (CO = SV x HR) increases commensurate
anaerobic training, in conditions where oxygen deliv with overall metabolic demand. The immediate re
ery is significantly compromised, patients may rely on sponse to oxygen deficit is an increase in CO to in
anaerobic metabolism to sustain ATP production and crease oxygen delivery. This averts arterial desatura
break down to provide energy. Although anaerobic ex tion which is not normally observed in health even
ercise implies that the exercise is pelformed in the ab with extreme exertion.
sence of oxygen, anaerobic metabolism provides a The increase in systemic CO results in increased
short-term means of supporting phosphorylation using venous return and pulmonary CO. To oxygenate a
substrates other than oxygen to generate and split ATP. greater volume of blood in the lungs, an increased
If insufficient oxygen is available, the amount of ATP volume of air must be inspired. To effect an increase
that can be generated anaerobically is limited. Thus in VE, tidal volume (VT) and respiratory rate (RR)
this process can only be sustained for a short period. are increased. At low intensities of exercise, VT in
Lactic acid accumulates in the blood during anaerobic creases disproportionately to RR, whereas at moderate
metabolism. In healthy, untrained individuals, lactic to high intensities, VT plateaus and further increases
acid increases exponentially at an exercise intensity of in VE are effected by an increase in RR (Jones and
about 55% of maximal aerobic capacity (McArdle, Campbell, 1982). Exercise is associated with a small
Katch, and Katch, 1994). Anaerobic capacity and but significant increase in airway diameter and length
specifically the anaerobic threshold can increase with of pulmonary structures, hence, a reduction is airway
training, however, anaerobic training effects are less resistance. Zone 2, that is, the zone of greatest ventila
significant compared with the training effects achieved tion to pelfusion (V/Q) matching of the lungs, is in
with aerobic training. creased as a result o pulmonary capillary dilatation
Anaerobic metabol ism is thought to be triggered and recruitment. Diaphragmatic excursion is enhanced
by tissue hypoxia. The term anaerobic is a misnomer and the distribution of ventilation and perfusion is
in that oxygen is needed to pay the oxygen debt that more uniform throughout the lung, which helps mini
it creates. Thus in health, the need for oxygen is de mize atelectasis and airway closure. Exercise in
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270 PART III Cardiopulmonary Physical Therapy Interventions
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17 Mobilization and Exercise 271
Acute lung injury and pulmonary edema related with myocardial oxygen consumption, and
therefore myocardial work) oxygen consumption
Hemothorax
(V02), and carbon dioxide production (VC02). The
Pneumothorax
area of greatest ventilation to petfusion matching in
Cardiopulmonary insufficiency
the lungs, zone 2, is increased secondary to in
Cardiopulmonary sequelae of surgery creased dilatation and recruitment of pulmonary
Cardiopulmonary sequelae of immobility capillaries (West, 1995).
The hemodynamic benefits of exercise are maxi
mized in the upright position compared with recum
bent positions in that exercise alone fails to counter
the loss of volume regulating mechanisms associated
with recumbency (Sandler, 1986) See Chapter 18 for
diopulmonary dysfunction for which a rational basis the effects of position changes.
can be made for exploiting the acute effects of mobi Mobilization and exercise stimulate the endocrine
lization as a primary treatment intervention. system. Catecholamines, released to support the car
If the patient presents with acute cardiopul diovascular system, sustain a given exercise work
monary dysfunction, then primarily the acute ef rate. Increased sympathetic activity secondary to mo
fects of mobilization are indicated. These effects bilization can help reduce the patient's need for sym
are distinct from those that occur on assuming the pathomimetic pharmacologic agents (Bydgeman and
upright position. The majority of patients benefits Wahren, 1974). Sympathetic nerve stimulation, for
most from a mobilization and exercise stimulus example, is increased and sympathetic neurotransmit
when they are in the upright position. The effects of ters are processed more efficiently. This is a signifi
being upright vs. exercise. however, need to be cant effect that can be used as a goal for the prescrip
considered separately so that the benefits of their tion of mobilization.
individual and combined contributions can be de Central nervous system (CNS) responses to mobi
termined as well as any adverse reactions. The lization include arousal and priming of the various
physiological benefits of acute exercise are shown organ systems involved (Browse, 1965).
in the box on p. 272. The principal effects that re The prescription of mobilization and exercise to
mediate acute cardiopulmonary dysfunction are in stimulate their acute benefits parallels that of the pre
creased VE secondary to increased VT, RR, or scription of exercise for its long-term, central and pe
both; improved air flow rates and mucus transport. ripheral aerobic effects. The exercise parameters to
Cardiac output is increased secondarily to increased achieve long-term adaptations in healthy people have
stroke volume (SV), heart rate (HR) or both, and been well-defined by the American College of Sports
increased tissue perfusion. The particular benefits Medicine (1994) (Table 17-1) and are well-accepted.
of acute mobilization and exercise that need to be The individual engages in aerobic exercise at a heart
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272 PART III Cardiopulmonary Physical Therapy Interventions
!- Constipation
i Circulating blood volume
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17 Mobilization and Exercise 273
Step 1
Identify ALL factors contributing to deficits in oxygen transp0l1 (Chapter I), that is, those factors contributed to by:
Step 2
Determine whether mobilization and exercise are indicated, and if so, which form of either will specifically address
the oxygen transport deficits identified in Step I.
Step 3
Match the appropriate mobilization or exercise stimulus to patient's oxygen transport capacity.
EXAMPLES: activities of daily living (ADLs). walking unassisted, standing erect with assist and taking a few steps,
transferring from bed to chair*, seated dangling position over bed side, moving in bedt
Step 4
Set the intensity within therapeutic and safe limits of the patient's oxygen transport capacity.
Step 5
Combine the various body positions especially in the erect position with the following maneuvers:
I. Thoracic mobility exercises. that is, flexion, extension, side tlexion, and rotation
Step 6
Set the dUnltion of the mobilization sessions based on the patient's responses (i.e., changes in measures and indices
of oxygen transport) rather than time.
Step 7
Repeat the mobilization session as often as possible based on its beneficial effects and on is being safely tolerated by
the patient.
Step 8
Increase the intensity of the mobilization stimulus. duration of the session, or both comml!l1surate with the patil!nt's
capacity to maintain optimal oxygen transport when confronted with an increased mobilization stressor, and in the
absence of distress; monitored variables to remain within predetermined threshold range.
':'AII sitting positions requ i re upright ereci silting; propped up, semi recumbenl, slouched or slumped posit ions although approximaling the
u pri gh t position are NOT physiologically comparable
i-No amount of movement or activity is too sm.,lIlo derive benefits acutely or over long-Ierm
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274 PART III Cardiopulmonary Physical Therapy Interventions
TABLE 17-1
SPECIFICATIONS
Parameter
Exercise Type Rhythmic activity, involving the large muscle groups; the legs, arms or both
InLensity 70% to 85% of the age predicted maximum heart rate or observed maximum heart rate
Duration 20 to 40 minutes
Frequency Three to five times a week
Course 6 to 8 weeks
Adapted from the American Col lege of Sports Medicine, (1994). Guidelines for exerc ise testing and prescription. (6th ed.). Philadelphia:
Williams and Wilkins .
ADLs-independently, with one or more assisting would not be realistic, ethical, or indicated. Thus exer
cise is prescribed that is sufficient to elicit progressive
Standing-independently, with one or more assisting
physiological adaptation within defined limits of cer
Transferring-independently, with one or more
tain objective and subjective responses, such as per
assisting
ceived exertion, shortness of breath, angina, discom
Dangling-independently, with one or more assisting
fort/pain, and general fatigue. Considerable research,
Cycle ergometry in bed (lower extremity)
however, is needed to refine the prescription of mobi
Turning in bed lization and exercise for their acute effects in patients
Bed exercises with acute cardiopulmonary and cardiovascular dys
function. Furthermore, the specifications for low level
Supplemental Aids and Devices for Mobilization
exercise needed to affect long-term acrobic adaptation
For the patient:
have not been elucidated in dctail. However, based on
Walking aids, such as crutches, cane, intravenous
physiological understanding of acute exercise re
(IV) pole, wheelchair, orthoses
sponses and cardiopulmonary pathophysiology, prin
Weights
ciples for prescribing mobilization for acute car
Pulleys
diopUlmonary conditioning can be formulated.
Monkey bar
Grab bars
Mobilization Testing
Grab rope
Evaluating a patient's response to a mobilization
For the PT:
stimulus can be assessed in two ways. First, the pa
Transfer belts
tient can be exposed to a mobilization challenge test.
Mechanical lifts for patients The patient is monitored before, during, and after
mobilization activities (see box at left). Relatively
low-intensity activities such as bed exercises, moving
in bed, changing body position, sitting up, dangling
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17 Mobilization and Exercise 275
over bed side, transfer to chair, chair exercises, and in the previous couple of hours, be as attentive and
short walks with assistance, constitute a sufficient aroused as possible and be experiencing minimal
stimulus to elicit the acute effects of exercise. The de pain or discomfort. Review of a patient's medication
gree of assistance required to perform the activity schedule will ensure treatments are well-timed with
should be noted, since this significantly influences respect to pain medications, and medications that in
the patient's individual effort. Second, if the patient's terfere with a good treatment response, such as nar
status is unstable and oxygen transport is severely cotics. The patient's clothing should not be restric
jeopardized, then monitoring a patient during stan tive, and any lines, leads, and catheters should not be
dard care and procedures, such as turning the patient, taut. Any equipment, monitors, and IVs need to be
ADLs, nursing and medical procedures, can provide appropriately positioned to avoid disconnections or
an indication of the patient's physiological responses mishaps. Mobilizing the patient in intensive care re
to mobilization and the capacity of the oxygen trans quires positioning of the mechanical ventilator and
port system to meet the metabolic demands imposed. other supports before moving the patient. The PT
No movement is too small. Any movement that is must prepare personnel before moving a patient par
sufficient to perturb the oxygen transport system, no ticularly if one or more assists are required. Despite
matter how minimal, is sufficient to elicit short- and the number of persons assisting, the goal is usually
long-term gains. to have the patient perform as much of the mobiliza
tion activity as possible. Even small degrees of phys
ical movement can provide sufficient stress to the
Monitoring
cardiopulmonary system to be beneficial.
Patients for whom mobilization is prescribed require The basic components of the mobilization session
monitoring. Because of the stress to the oxygen trans are comparable to the components of an exercise ses
port system that mobilization elicits, the following sion described by the American College of Sports
variables in addition to the oxygen transport vari Medicine for long-term training effects (Figure 17-1).
ables, are most useful to monitor: heart rate (HR), Wherever possible, the session should include the
systolic and diastolic BP, RPP, RR, Sa02, arterial following components: warm-up, steady-rate, cool
blood gases, ECG and subjective responses. down, and recovery. These components are less dis
tinct when a patient has minimal functional capacity
or is being mobilized to remediate acute cardiopul
Mobilization Prescription
monary dysfunction. The rhythmic movement of
Prescribing a mobilization stimulus for its acute ef large muscle groups is ideal. Prolonged static maneu
fects parallels the prescription of exercise for its long vers are usually avoided particularly if the patient is
term effects with some important differences. In an severely ill, because of their disproportionate hemo
acute patient, a mobilization or stimulus often results dynamic response. The movements that are usually
in a greater response gain than such a stimulus in considered when mobilizing a patient include: turn
subacute and chronic patients. In addition, to the ing, sitting up, shifting, transferring, standing and
rapid favorable response an acute patient may have to taking some steps. These can be extremely metaboli
acute exercise, the patient may exhibit a negative re cally demanding for patients with significant acute
sponse just as quickly. Thus judicious monitoring of cardiopulmonary dysfunction. Thus pacing the mobi
treatment response in these patients is essential. lization session allows the patient to rest between
The scheduling of and preparation for a mobiliza stages. The patient is reassured and encouraged to
tion session is crucial to the response that can be ex relax and coordinate deep breathing and coughing
pected. The following conditions should be adhered with the activity. Throughout the session, attention is
to as closely as possible; and their details should be given to the patient's biomechanical alignment, and
recorded so that any factor that significantly influ postural erectness and stability. Back extension or
ences the response to treatment can be identified. body positioning minimizes slumping of the chest
The patient should be rested, not have eaten heavily wall and compromised ventilation. In this way, chest
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276 PART III Cardiopulmonary Physical Therapy Interventions
140r Trai in ,
scribing the exercise stimulus results in less potent ef
I\ 1 fects and overprescribing results in an excessive,
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17 Mobilization and Exercise 277
verely ill patients are often unable to respond effec a response-dependent duration and frequency, there is
tively. Compared with the condition of chronic pa a cumulative adaptive response to that repeated stimu
tients, the condition of acute patients tends to vary lation, or a long-term, training response. In decondi
more within and between sessions and afterward, tioned individuals with low functional work capacity,
which necessitates greater monitoring. or whose oxygen transport system has been compro
Monitoring needs to be performed continuously mised by disease, the exercise intensity associated
for patients for whom acute mobilization has been with relatively low-intensity mobilizing activities such
prescribed. First, a baseline of the patient's resting as bed exercises, moving in bed, sitting up, dangling
metabolic state needs to be established. Second, the over bed side, transferring to chair, chair exercises,
metabolic responses to stimuli that perturb oxygen and short walks with assistance, constitute a sufficient
transport and the lability of this response needs to be stimulus for long-term adaptation. However, optimal
established. Obtaining such a profile provides some adaptation only occurs if these activities are pre
indication of the upper limit of the target intensity scribed at a requisite intensity, duration, and fre
range for mobilization. The target intensity range can quency and the exercise prescription progressed com
be defined in terms of an upper and lower level of mensurate with the individual's adaptation.
various physiologic variables. The most commonly Mobilization activities prescdbed to enhance oxy
used are HR, BP, RPP, RR, perceived exertion or gen transport, can be coupled with resistive muscle
breathlessness. Monitoring during nursing procedures work to increase muscle strength and endurance (e.g.,
and other types of routine care provides an indication weights, use of a monkey bar for moving in bed and
of the patient's functional capacity without having to sitting up, manual resistive exercise, the use of wrist
conduct a modified exercise test. or ankle weights, ergometry, and walking). Coordi
Alternatively, a mobilization or exercise challenge nating postural, thoracic mobility and upper extrem
can be given. The patient's response is compared ity exercises with inspiratory and expiratory efforts
with resting baseline measures. The quality as well as can be effective in stimulating increased VT, and im
the immediacy of the response is documented. The proved ventilation and perfusion matching. Chapters
characteristics of the quality of response is also 2l and 22 illustrate how such movement and breath
recorded. Is the response commensurate with the in ing patterns can be coupled to maximize oxygen
tensity of the exercise stimulus? With cessation of transport in neurological patients. Such coordinated
exercise do the responses revert to baseline? If so, exercise, however, can also be used with patients
how fast? Do the variables return to baseline or re with acute cardiopulmonary conditions. Isometric
main above baseline? type exercises, postures that require increased muscle
The variables to be measured depend on the pa work for stabilization, and activities that elicit the
tient (see Chapters I and 16). Most commonly, HR, Valsalva maneuver produces disproportionate hemo
ECG, BP, RPP, RR, and subjective symptoms, are dynamic responses, which could be detrimental. The
basic measures and indices of exercise response that capacity of the patient to respond appropriately to
require no invasive procedures. At the other end of these loads needs to be established beforehand.
the spectrum is the critically ill patient who has vari In the management of acute cardiopulmonary dys
ous invasive lines and monitoring equipment, includ function, the parameters of mobilization stimuli in
ing hemodynamic monitoring and intracranial pres clude a relatively low intensity (although often per
sure monitoring. This patient requires more specific ceived as intense by the patient), short duration, and
and frequent measures of oxygen transport. high frequency of sessions. If the patient is severely
compromised (e.g., end-stage heart or lung disease)
interrupted or interval training is indicated. This type
Adaptation to an Acute Mobilization Stimulus
of training is characterized by either on-off exercise,
When an individual is exposed to repeated exercise which allows for rest in between bouts of exercise, or
stress, that is, of a specific threshold intensity, and for high-low intensity of activity. The volume of work
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278 PART III Cardiopulmonary Physical Therapy Interventions
TABLE 17-2
Mobilization activities 5to 20 min I time per I to 2 hours to 4 to 6 times per day
Interval continuous aerobic exercise 5to 20 min I time per I to 2 hours to 4 to 6 times per day
Continuous aerobic exercise (light) 5to 20 min I time per I to 2 hours to 4 10 6 times per day
Continuous aerobic exercise (moderate) 20 to 40 min 2 to 3 times daily to once daily
Continuous aerobic exercise (heavy) 20 to 40 min Daily to 3 to 5times per week
that can be achieved in an interrupted protocol by a beds with lines and leads is crucial, because it is these
severely compromised patient, is significantly greater patients who benefit significantly from exercise stress
than during continuous activity. With physiological and also succumb most severely to its removal.
adaptation over time, the exercise period can be in The goal is to adapt the patient to multiple ShOl1 mo
creased and the rest period decreased, and possibly bilization sessions per day, as frequently as once per
eliminated. When high- and low-intensity exercise is hour, and progressively increase the intensity of these
alternated the work load can be progressed by either sessions, reduce the duration and conespondingly re
increasing the respective loads in each phase or by in duce the frequency of sessions. Table 17-2 illustrates
creasing the duration of the higher load period. If the the inverse relationsrup between mobilization and exer
patient has low functional work capacity but suffi cise intensity, duration, and frequency of the sessions.
cient physiological reserve, adaptation can be rapid,
necessitating small, frequent progressions. As the pa
Multisystem Effects of Mobilization
tient's aerobic capacity increases, the response gains
are correspondingly smaller. If the patient has both Acute exercise affects most organ systems in addition
poor functional capacity and poor physiological re to the cardiopulmonary and cardiovascular systems.
serve capacity, progress would be correspondingly The neurological system is primed for activity. To
slower and less significant. counter postural perturbations, reflexes and postural
When mobilization activities are being prescribed control adjustments are activated. Blood flow is in
to remediate acute cardiopulmonary dysfunction, par creased to the working muscles commensurate with
ticularly in patients in the leU, extensive and often the intensity and duration, and therefore overall meta
invasive monitoring is required. This permits detailed bolic demand of the work. The endocrine system also
assessment, and ongoing metabolic assessment of the adjusts to largely stimulate the cardiopulmonary and
patient's treatment responses and recovery. With cardiovascular systems through a complex system of
these supports, mobilization and exercise can be pre neurotransmitters to support the oxygen demands re
scribed effectively in these patients. Judicious moni quired of the work rate imposed.
toring minimizes any inherent dangers of either under
or over prescribing the intensity of the exercise stim
PRESCRIPTION OF MOBILIZATION AND EXERCISE:
ulus (Part II). Special consideration has to be given to
lONG-TERM RESPONSES
the fact that various monitoring leads, lines, and
catheters may restrict certain body positions and ac In health, the long-term effects of exercise occur in re
tivities. Such encumbrances, however, do not pre sponse to a specific and sufficient exercise stimulus to
clude most activities including ambulation. Moving which the individual is exposed for a finite period. With
relatively immobile patients who are tied to their respect to aerobic training or adaptation, the essential
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17 Mobilization and Exercise 279
i Respiratory muscle strength and endurance i Efficiency of postural retlexes associated with type
of exercise
i Collateral ventilation
i Pulmonary vascularization
i Reflex control
Exercise-illduced bradycardia
i Myoglobin
J Stroke volume at rest and submuximal work rates i Muscle metabolic enzymes
J.. Submaximal heart rate. blood pressure, and rate i Improved biomechanical efficiency
i Optimize number of red blood cells i Efficiency of hormone production and degradation
to support exercise
i Optimize hematocrit
training parameters appear in the box above. As adapta tion and hemodynamic responses to submaximal exer
tion to the exercise stimulus occurs, each step in the cise are decreased. The subjective experience of exer
oxygen transport system becomes more efficient facili cise stress is also reduced. These training effects are
tating oxygen delivery, uptake and extraction at the cel commensurate with increases in the efficiency of oxy
lular level. The long-term effects of aerobic exercise gen transport at each step in the pathway.
are summarized in the box above. In addition to an in As the body adapts to the exercise training stimu
crease in maximal oxygen consumption, training results lus, the intensity needs to be increased to elicit fur
in an exercise-induced bradycardia and increased stroke ther training benefit. This is the basis for the physio
volume at rest and a reduction in the physiological de logical adaptation to an exercise training stimulus.
mands of submaximal work rates. Specifically, ventila- Depending on the goals of the exercise prescription, a
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280 PART III Cardiopulmonary Physical Therapy Interventions
Chro1lic Pathophysiological Conditions That Benefit From the Long-Term Effects of Mobilizatio1l and Exercise
Quadriplegia Alcoholism
Paraplegia P regnanc y
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17 Mobilization and Exercise 281
Severe cardiomegaly
Pulmonal), hypertension
Resting tachycardia
differs. Comparable with prescribing mobilization
Resting electrocardiogram (ECG) abnormalities
in acute conditions, prescribing exercise for long
term adaptations is based on the patient's presenta Poorly controlled diabetes
level, lab and investigative reports related to physio Severe systemic hypertension
logic reserve capacity, the exercise test and the Significant conduction disturbance
goals of the exercise prescription.
Complete atrioventricular block
potential risk to the patient, therefore exercise testing Left ventricular failure
must have clear indications, and any contraindications Epilepsy
must be ruled out. The indications for exercise testing
are numerous (see box above, at left). They range
Adapted from Jones. N.L. (1988). Clinical Exercise Testing.
from quantifying maximum functional capacity to as- (3rd Ed.). Philadelphia: WB Saunders.
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282 PART III Cardiopulmonary Physical Therapy Interventions
TABLE 17-3
Subjective Scales of Exercise Responses Based on the Borg Scale of Rating of Perceived Exertion
sessing endurance during low level ADLs. Contraindi the ratings can be used to compare the patient's sub
cations are classified as either relative or absolute (see jective exercise responses over repeated tests.
box on p. 281, at right). Absolute contraindications Depending on the functional impairments and ca
prohibit the safe conduction of an exercise test, pacity of the patient, the exercise test can be one of
whereas the presence of relative contraindications re various types depending on the objective of testing
quires that the test, protocol, physiological variables and potential training. If exercise training is an objec
monitored, or the end point of the test be modified. tive of the exercise test, the activity used in the test
Both the indications for the test and any contraindica should be comparable with that to be used in training.
tions must be clearly established before performing an Physiological responses and adaptation to exercise
exercise test. are highly specific to the training stimulus (the speci
The guidelines used to test and train healthy peo ficity of exercise principle). Thus if walking is to be
ple with no disease states are not directly generaliz the training activity, the test should be a walking test
able to chronic medically-stable patient populations. rather than cycling.
Because of functional impairments in these patients There are numerous variants of standard exercise
(e.g., secondary to cardiopulmonary, cardiovascular, tests (Table 17-4). These are categorized as continuous
neuromuscular, and musculoskeletal dysfunction) ex and interrupted tests. Continuous tests include maxi
ercise testing and training must be modified. More mal and submaximal incremental tests and steady-rate
over, patients who are physically challenged experi tests, and interrupted tests include maximal interval
ence more subjective symptoms in response to and submaximal interval tests. Interrupted tests are de
exercise compared with healthy people, therefore signed for patients with low functional work capacity
monitoring the subjective responses to exercise is es who cannot sustain prolonged periods of aerobic exer
sential. The Borg scale of rating of perceived exertion cise. These patients can perform more work over time
can be modified for clinical use to score breathless when the work load is administered in an interrupted
ness, discomfort, pain, and fatigue (Table 17-3) or periodic manner. Specifically, the test alternates
(Borg, 1970; 1982). If the endpoints of the scale are fixed periods of work and rest, or high and low intensi
well-described and understood by the patient, then ties of exercise. The proportions of work-to-rest or
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17 Mobilization and Exercise 283
TABLE 17-4
Continuous Tests
Interrupted Tests
Maximal or Submaximal Establish level of functional capacity in patients with extremely low functional
work capacity
On-off protocol or high-low intensity protocol, such as 5 min on to I min off; alternate
high- and low-intensity exercise in cycles, such as I minute high to 15 seconds low
high-to-low exercise intensity is set according to the treadmill or ergometer, which jeopardizes stringent
patient's level of impairment. One patient, for exam test control (Dean and Ross, 1992a).
ple, may be able to tolerate 3 to 5 minutes of relatively Like other diagnostic or testing procedures, the va
high intensity work to I to 2 rrlinutes of low-intensity lidity and reliability of the exercise test depend on the
work, whereas another patient may be able to tolerate quality of the procedures used. The preexercise test
only 1 minute of low intensity work to 10 to 20 sec conditions and the preparation and testing procedures
onds of rest. need to be standardized (see boxes on pp. 284-285).
For maximal standardization and the capacity to The test is terminated as soon as the sign or symptom
perform more comprehensive monitoring, stationary criteria for terminating the test is reached or the crite
exercise modalities such as the treadmill, ergometer, ria for prematurely terrrlinating the test is reached (see
or step are recommended. However, there may be in box on p. 286). Recording the test conditions and pro
dications to perform an exercise test without a modal cedures in detail is essential. An example of an exer
ity, such as the 12-minute walk test or some variant cise test data sheet that can be modified to any testing
like 6 or 3 minutes (McGavin, Gupta, and McHardy, protocol using an exercise modality is shown in the
1976). Standardization of such tests, however, is box on p. 287, at left. Many patients are unable to be
more difficult. Practice has a significant effect on the exercise tested using a modality. These patients can
results of the 12-minute walk test, thus this test needs walk on a marked circuit. An example of an exercise
to be repeated several times to achieve a valid test. test data sheet is shown in the box on p. 287, at right.
Also, the instructions for this test are less well Systematic and detailed record-keeping will maximize
standardized clinically compared with those for the the test validity and its interpretation as well as ensure
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284 PART III Cardiopulmonary Physical Therapy Interventions
Ensure patient is free of any acute illnesses including influenza and colds for 48 hours.
Ensure patient understands the purpose of the test and provides signed consent.
Ensure patient has not eaten heavil y . has avoided caffeinated beverages and has refrained frolll smoking for at least 3
hours before testing.
Ensure patient is rested and has not e x ercised, or is not being excessively exerted for at least 24 hou rs before testing .
Ensure patient is app ro priate ly dressed, for exampl e , shorts, n onbindi n g clothes, short-sleeve shil1. socks, running or
walking shoes that have proper SliPPOI1, and secured laces or fastenings.
Orthoses should be worn unless the test is evaluating changes in functional capacity with and without nn orthosis.
Ensure patient understands the subjective rating scales and is able to read them when held at an nppropr i ate distance.
Select the type of exercise test, the pr otoc 01 and the exercise test termination criteria beforehand.
Ensure the patient is familiar with and has practiced performing the test or test activity preferably before the test day
to reduce arollsal, improve movement efficiency . and maximize test validity.
that the same procedures are used in follow up tests exercise capacity and are unable to tolerate being
thereby maximizing the abi Iity to compare test results. tested on an exercise modality. A major disadvan
It is imperative that retests are conducted comparably tage, therefore is that the patient cannot be as com
in every respect to the original test with respect to pa prehensively monitored. Thus patients need to be se
tient preparation and the procedures. lected carefully to undergo a 12-minute walk test or
one of its variants.
Knowledge of the patient's functional ability
Exercise Tests and Protocols
based on verbal report can be useful and can serve as
Depending on the functional capacity of the patient, a guideline for determining the exercise test, its para
the exercise test can be a continuous maximal, sub meters, and what tile patient's termination criteria
maximal incremental or steady-rate, or an interrupted should be. Although these verbal reports do not re
maximal or submaximal test. The protocol for the test place an exercise test, they can be used as an adjunct.
and the end points to be used in terminating the test The oxygen cost diagram is shown in the box on p.
are determined beforehand depending on the indica 290, at left. This visual analog scale is constructed of
tions for the test and the objectives. Some commonly a 100 mm line; the high end of the scale represents
used protocols are shown in Figure 17-2 along with a strenuous activity, that is, walking briskly uphill, and
comparison of the energy expenditure of the various the low end of the scale represents no activity, or
work stages in their protocols. sleep. The patient crosses the line at the point where
The 12-minute w a lk test a n d i t s varian ts, 6 breathlessness does not allow continuation when at
minute- and 3 minute-walk tests, were designed to the patient's best. Figure 17-3 shows an incremental
test patients with lung disease (McGavin, Gupta, ladder of workloads associated with step increments
and McHardy, 1976). These tests have been favored in metabolic cost, (hat is, multiples of resting or near
clinically, because they are functional and do not re resting metabolic rate (resting metabolic rate = I
quire exercise equipment. However, these tests are MET, or 3.5 ml 02/mink
i g
often used for patients who have extremely impaired of metabolic costs ranges from very light to very
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17 Mobilization and Exercise 285
Preparation
Patient ch,mges into exercise clothes and shoes (not new); ensure laces are secure.
If the ergometer is used. the seat-to-pedal distance must be established before the test, and the seat should be adjusted
to allow for 15 degrees or knee extension when the foot is lowennost in the pedal in the revolution cycle; the knee
must not extend fully.
Monitors are allached (e.g., heart rate, ECG, blood pressure cuff, pulse oximeter) and the subjective rating scales are
explained.
Testing procedures are explained and demonstrated; the patient has an opportunity to answer questions.
General Procedures
Unnecessary conversation and interaction with the patient is kept to a minimum throughout all stages of the test, in
cluding postexercise recovery, to optimize the validity of the measurements and the test results overall.
Resting baseline measures are taken over 5 minutes or ulltil they have plateaued.
Patient stands 011 treadmill or sits erect on cycle ergometer with feet securely strapped into place on the pedals; the
metatarsal heads should be positioned comfortably over the pedals.
Patient uses two fingers for balance on one side if possible when walking on the treadmill rather than a hand grip, or
ir on the ergometer, not the excessively grasp the handle bar.
Additional baseline measures are recorded in this position for 2 to 3 minutes or until the baseline is stable.
Patient is monitored objectively and subjectively at least every couple of minutes throughout all stages of the test. in
cluding postexercise recovery.
The test is terminated when the preset exercise test termination criteria or any of the criteria for prematurely terminat
ing an exercise test are reached.
When the cooldown portion of the protocol is complete, the patient moves to the supported chair for the postexercise
recovery phase with legs slightly elevated and uncrossed.
Postexercise recovery continues until resting baseline measures have been reached or are within 5% to 10%.
Monitoring
heavy actIVItIes. One limitation of such charts on
metabolic costs of various activities and exercise is Common variables measured during an exercise test in
that they can only be used as a rough g uide in pa clude HR, ECG, systolic and diastolic BP, RPP, RR,
tients with cardiopulmonary compromise, as they do Sa02 and subjective responses such as perceived exer
not take into consideration the increased work of tion, breathlessness, discomfort, pain, and fatigue. Mea
breathing and work of the heart observed in patients sures are taken every few minutes after the patient has
with cardiopulmonary dysfunction. been exercising at a given intensity for a few minutes.
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286 PART III Cardiopulmonary Physical Therapy Interventions
Miscellaneous
Lightheadedness, confusion, ataxia, pallor. cyanosis, dyspnea, nausea, or peripheral vascular insufficiency
Onset of angina
ECG Signs
Appearance of a Q wave
Cardiovascular Signs
Inappropriate bradycardia (drop in heart rate greater than 10 beats/minute with increase or no change ill work load)
Adapted from the American College of Sports Medicine, (1994). Guidelines for exercise testing and prescription.
(6th ed.). Philadelphia: Williams and Wilkins.
Adapted from Jones, N.L. (1988). Clinical Exercise Testing. (3rd Ed.). Philadelphia: WE Saunders.
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17 Mobilization and Exercise 287
Exercise Test Data Sheet for Treadmill Exercise Test Data Sheet for a Walk Test
or Ergometer on a Circuit
Date: Date:
Minute Work rate HR BP RPP RR Sa02 RPE Minute Work rate HR BP RPP RR Sao2 RPE
speed/grade speed/grade
(work/rpm) (work/rpm)
o o
2 2
3 3
4 4
5 5
6 6
Use of orthoses: type and side Use of orthoses: type and side
How often docs the patient experience the level of How often does the patient expelience the level of
exertion reached in the test (e.g., lx/ wee k , exertion r e a c h e d in t h e test (e.g., I x/week,
lx/month, 3x/day. etc.) lx/month. 3x/day. etc.)
NOTE: 'Relevant notes and comments include abnormal ECG NOTE: 'Relevant notes and comments i nclude abnormal ECG
changes, comments by patient, observations about coordination, changes, comments by patient, observations about coordination,
and anxiety. and anxiety.
Copyrighted Material
I\)
CD
CD
::0
>-l
-
-
Functional Clinical 02 cost Bicycle -
Treadmill protocols
class status ml/kg/minute METS ergometer ETS (j
Balke "slow" .,
Bruce Kattus Ellestad USAFSam McHENRY Stanford Q.
1 Watt = Ware USAFSam o·
"0
60 KPDS 3=minute =
%Gr 3/2/3= 2=or3= %Gr %Gr
2::- stages 3"
: at minute minute at at o
For mph %Gr ::J
u 3.3 MPH stages stages 3 2
1 20
.,
0
70 kg 5.5 mph mph
'<
Q) 1 =minute
C> bod
Normal
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stages mph %Gr '<
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and
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56.0 16 5.0 1 18 25 6 1 15 mph %Gr e:..
1 52.5 15 24 >-l
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1500
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21
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18
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42.0 12 1350
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4 "
-£ 16 mph %Gr
1-
38.5 11 1200
4 1 14
15
14
5 1 10 3.3 l 15 20.0
3.31 15 t--- -.lL
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:c 35.0 10 13 2 1 25 17.5
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-£ 1050 3.4 1 14 12
33 1 12 1 15.0 o·
-0 31.5 9
900
4 1 10 11
10 4 1 10 2 1 20 . -.!L.. 5l
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...r:::. 28.0 8 9
8 3.3 1 10 3.3 1 9 12.5 8
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24.5 7
750
2.5 1 12 3 1 10
7 3 1 10 2 1 15 10.0 7
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6
.2 5 1 6
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2 1 10
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0"5 1 10
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3
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4 3.5 1 1
FIGURE 17-2
Oxygen cost of work stages of some commonly used exercise test protocols. (Reprinted with
permission from Froehlicher YF: Exercise and the heart, ed 2, Chicago, 1987, Year-Book.)
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17 Mobilization and Exercise 289
10 + METs
FIGURE 17-3
Swimming
Energy cost in METS of activity and exercise. (crawl,55
(From Underhill, SL et at: Cardiac nursing, ed 2, yard/minute
Philadelphia, 1989, JB Lippincott.) Skiing, fast
9 METs downhill
Walking up
hill,5 mph
8 METs
Cycling, 13 MPH
Swimming, 40 + yard/ minute
Level ski touring, 4 MPH
Cross-country running
7 METs Walking on level,5 to 6 mph
6 METs
Shoveling snow
Digging vigorously
Sawing wood
Tennis
5 METs Skiing
Walking on level, 5 mph
4 METs
Gardening (weeding)
Ballroom dancing
Canoeing, golF
Bedmaking
3 METs Woodworking (drilling, sawing)
Self-care Walking on level ground, 4 mph
washing
dressing
2 METs
Light calisthenics
Driving (can be more MET under stressful conditions)
light housework (sweeping, ironing, mopping)
Walking, 2.2 mph
1 MET
Resting
Eating
Writing
Handsewing
Knitting
Very light activity Light activity Moderate to heavy activity Very heavy activity
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290 PART 1II Cardiopulmonary Physical Therapy Interventions
Oxygen Cost Diagram Used to Assess Patient's Check List Before Exercise Testing or
Breathlessness on Exertion Training Session
Slow walking on the level Wearing or using orthoses, walking aids. and devices
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17 Mobilization and Exercise 291
to set exercise intensity, the patient must be closely Urine stasis, retention. tendency toward calculus
monitored. This is particularly true if the patient has formation
their exercise sessions. When the patient is safely carry Increased venous compliance
ing out the exercise program independently in the com Increased risk of venous thrombosis and throm
munity some mechanism is needed to follow-up on the boembolism
patient's progress. If the objective is continued condi Decreased orthostatic tolerance
tioning, then the patient needs to be rescheduled for a
Cardiovascular deconditioning
retest. If the patient is on a maintenance program, the
Decreased V02 max
PT is responsible for reminders about exercise and in
Anorexia
jury precautions, and notifying the PT or physician if
significant adverse effects are observed. Constipation
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292 PART III Cardiopulmonary Physical Therapy Interventions
bile, is nonphysiologic (Chapter 18). The harmful se 1951). Thus alveolar-arterial oxygen difference and
quelae of this posture have been well-documented arterial oxygen tension are reduced during periods
(Dean and Ross, I 992b) yet the more severely ill the of bed rest (Cardus, 1967; Clauss, Scalabrini, Ray,
patient, the more-confined that individual is to the and Reed, 1968; Ray et aI, 1974). Closing volumes
bed, and the greater the risk of multisystem complica are increased precipitating arterial desaturation in
tions (see box on p. 291). recumbent positions.
The immediate effects of immobility that are ob Cardiovascular sequelae of prolonged recumbency
served are those associated with recumbency; these include an increase in resting and submaximal heart
are followed within 24 to 48 hours by cardiopul rate (Deitrick, Whedon, and Shorr, 1948), a decrease
monary and musculoskeletal changes. Within 24 in maximum oxygen uptake (Saltin et ai, 1968), and a
hours, significant fluid shifts occur and blood vol decrease in total blood volume, plasma volume, and
ume is reduced by 10% to 15%. Within days, these hematocrit (Deitrick et aI, 1948; Saltin et aI, 1968;
effects can significantly impair oxygen transport. Friman, 1979). The combination of an increase in
These systemic effects are more profound in pre blood viscosity and a decrease in venous blood tlow
mature infants, young and older people, smokers, results in an increased risk of thromboemboli (Lentz,
obese and deconditioned individuals. These effects 1981; Wenger, 1982).
are further compounded when a patient has either Musculoskeletal changes that occur with bed rest
primary or secondary cardiopulmonary and cardio deconditioning include loss of muscle mass and
vascular compromise. The less aerobically fit an strength, muscle and ligament shortening, joint contrac
individual, the less physiological reserve is avail tures, skin lesions, and decubitus ulcers (Rubin, 1988).
able in the cardiopulmonary and cardiovascular CNS changes include slowed electrical activity of
systems. In the event of a medical or surgical in the brain, emotional and behavioral changes, slowed
sult, such a patient will have an increased risk of reaction times, sleep disturbances, and impaired psy
morbidity and mortality than a more fit counter chomotor performance (Rubin, 1988; Ryback, Lewis,
part. Thus tl1e importance of aerobic fitness cannot and Lessard, 1971; Zubeck and MacNeil, 1966).
be overemphasized. Metabolic changes that occur during periods of
A primary effect of mobilization and exercise on bed rest include reduced insulin sensitivity and glu
the cardiopulmonary system is enhanced mucocililary cose intolerance (Mikines, 1991), increased calcium
transport and clearance (Wolff, Dolovich, Obminski, excretion from bone loss and increased nitrogen ex
and Newhouse, 1 977). Frequent body position cretion secondary to protein loss from atrophying
changes are essential to maintain optimal bronchial muscle (Deitrick et ai, 1948; Donaldson, Huliey, and
hygiene and avoidance of pooling and stagnation of McMillan, 1969; Hulley, Vogel, Donaldson, Bayers,
bronchial secretions, hence, airway obstruction and Friedman, and Rosen, 1971).
airt10w resistance (Chapter 18). Bed rest has been associated with a reduction in
The primary effects of bed rest on the cardiopul antibody counts, hence an increased risk of infection
monary system result from recumbency. Pulmonary (Ahlinder, Birke, Norberg, and Plantin, 1970).
sequelae of recumbency included reduced lung vol Of clinical significance is the fact that car
umes and capacities, particularly functional residual diopulmonary and cardiovascular deterioration
capacity (FRC), residual volumes (RV) and forced occur at a faster rate than musculoskeletal deterio
'
expiratory volumes (FEVs) (Blair and Hickman, ration, and that the rate of recovery from the ill ef
1955; Craig, Wahba, Don, Couture, and Becklake, fects of bed rest is generalJ y slower than the rate of
1971; Hsu and Hickey, 1976; Powers, 1944; Risser, impairment (Kottke, 1966; Sandler, Popp, and Har
1980; Svanberg, 1957). A reduction in FRC in rison, 1988).
supine position compared with the sitting position The negative effects of bed rest are accentuated in
has been attributed to both a decrease in thoracic older adults (Harper and Lyles, 1988), and are likely
volume and an increase in thoracic blood volume, to further compound the oxygen transport and other
hence pulmonary venous engorgement (Sjostrand, deficits of patients with pathology.
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17 Mobilization and Exercise 293
HAZARDS OF BED REST tural alignment, stiffness, and soreness. Bed rest allo
cates various body parts to being weight bearing.
The literature on the negative sequelae of bed rest has
Skin breakdown most commonly occurs over boney
been unequivocal for 50 years (Chobanian, et aI.,
prominences such as the sacrum, trochanters, elbows,
1974; Dean and Ross, 1992b; Dock, 1944; Harrison,
scapulae, and heels. Muscles imbalance may result
1944; Ross and Dean, 1989). Thus the use of bed rest
from poor postural alignment. Patients are at risk of
as a primary medical intervention requires consider
bone demineralization. Of particular importance in
able justification. The recumbent, immobile positions
older populations, patients with disabilities, post
associated with bed rest adversely affect every organ
menopausal women, and patients on steroids is cal
system and palticularly compromise oxygen transport
cium loss secondary to bed rest or sedentary lifestyle.
by its direct negative effects on the cardiopulmonary
Bed rest affects psychological status. Patients may
and cardiovascular systems. This is particularly signifi
become depressed, sensorily deprived, or develop a
cant in that in conventional patient management there
psychoneurosis with prolonged bed rest.
is a direct relationship between how sick the patient is
The evidence supports the following:
and the amount of time confined to bed. In addition,
I. Evidence supporting the wide spread use of bed
the musculoskeletal and neurological systems are ad
rest as a therapeutic intervention is lacking.
versely affected.
2. Currently the use of bed rest is excessive and
The cardiovascular sequelae of bed rest primarily
nonspecific.
include the loss of fluid volume regulating mecha
3. Bed rest has multisystem negative effects and
nisms, diuresis, and loss of plasma volume. In turn,
therefore must be used judiciously and specifically.
the hematocrit is increased, and the risk of develop
4. Alternative means of managing very ill pa
ing deep vein thromboses and thromboemboli is in
tients, such as those in the intensive care, must
creased. This is exacerbated by increases in blood
be developed.
viscosity, platelet count, platelet stickiness, plasma
fibrinogen (Browse, 1965), and stasis of venous
ALTERNATIVES TO THE NONSPECIFIC
blood flow. The work of the heart is increased in the
USE OF BED REST
immobile, recumbent patient as is the work of breath
ing. The work of the heart is increased as a result of With respect to developing alternative means of man
the increased filling pressures and heart rate associ aging very ill patients rather than in the recumbent
ated with recumbency, and increased blood viscosity. immobile positions, physical therapists need to be
The work of breathing is increased by the decreased come vocal in designing furniture and devices that
lung volumes secondary to visceral encroachment on are better suited to the patient's normal physiologic
the underside of the diaphragm, increased intratho functioning and to the needs of that patient's course
racic blood volume, and restricted chest wall motion. of recovery. Such appliances would include a greater
With bed rest, the blood vessels of the muscles and number of neurologic and cardiac chairs in ICUs,
splanchnic circulation dilate. With prolonged bed rest, which enable easy transfer of patients from bed to
they may lose their ability to constrict. The ability of chair and upright positioning, greater availability of
these vessels to constrict is essential to prevent the patient-lifting devices, and increased number of or
pooling of blood and maintain circulating blood vol derlies to assist with moving patients.
ume in the upright position. Thus following bed rest, a Rotating beds are electromechanical beds that turn
patient may feel lightheaded or dizzy, or may faint. the patient through an arc of about 30 degrees to ei
With only a few days of bed rest, skeletal muscle ther side from supine over a 3-minute period (Schim
atrophies leading to weakness, discoordination and mel, Civetta, and Kirby, 1977). These beds are used
balance difficulty (Lentz, 1981; Saltin, et aI., 1968). for heavy care critically ill patients who are unable to
With severe weakness, excessive strain may b e turn themselves or are difficult to turn. Even though
placed o n ligaments and joints. The limited position studies have shown these beds can enhance oxygena
ing alternatives in bed may contribute to poor pos tion in severely c o m promised patients such a s
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294 PART III Cardiopulmonary Physical Therapy Interventions
patients with adult respiratory distress syndrome agement of such patients. However, 30 years ago re
(Summer, Curry, Haponik, Nelson, and Elston, 1989; striction to a chair was reported to be significantly
Yarnel, Helbock, and Schwiter, 1986), they need to more beneficial than restriction to bed in heart dis
be used selectively to avoid reliance on passive posi ease patients (Levine and Lowe, 1954). Despite this
tioning with the bed vs. more active and active as finding, many coronary patients continue to recline in
sisted patient positioning. beds rather than chairs. Mobilizing coronary patients
The use of tilt tables to promote mobilization can be and permitting bathroom privileges has also been re
hazardous in that leg movement is minimal. Passive ported to be less stressful than being confined to bed
standing on a tilt table constitutes a greater physiologi and having to use a bedpan (Andreoli et ai, 1994).
cal stress than active standing. Upright sitting postures
with the legs dependent may elicit greater physiologi
Prescription of an Adequate Stimulus to Elicit
cal benefit than passive standing with less risk.
the Preventative Effects of Exercise
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17 Mobilization and Exercise 295
There is no literature, however, to support greater individual steps in the oxygen transport pathway
preventive effects turning a patient every 2 hours vs. that are primarily affected, and oxygen transport as
hourly or every 4 hours. Sitting up and ambulation a whole, such as oxygen delivery, oxygen consump
are two other practices that are also widely used. The tion, and oxygen extraction at the tissue level, are
timing of these interventions, however, is often based fundamental. Of considerable clinical relevance is
on convenience and what else may be happening with the adequacy of tissue oxygenation; however, to
the patient, or on a once or twice daily regimen rather date, there are no clinically expedient means of as
than on a prescriptive basis. Patients who are sitting sessing tissue oxygenation.
or walking for preventive reasons often assume sub
optimal and even deleterious slumped or malaligned
SUMMARY
postures. Patients and their caregivers need to be re
minded about the importance of proper body position This chapter described three distinct goals associated
at all times and be provided with appropriately sup with the prescription of mobilization and exercise in
ported chairs, firm bolsters, and adjustable beds that the management of impaired oxygen transport,
maintain optimal body positions. namely, to exploit their acute, long-term, and preven
Like exercise prescribed for its beneficial acute and tive effects.
long-term effects, exercise to elicit its optimal preven The PT needs a comprehensive and detailed un
tive effects should be prescribed based on the individ derstanding of how mobilization and exercise have
ual (e.g., age; premorbid functional work capacity; the potent and direct effects on oxygen transport acutely,
type, distribution, and severity of disease; and within in the long-term, and preventively. The specific mo
capabilities of patient). Such preventive mobilization bilization or exercise prescription is based on a com
or exercise must also be prescribed to avoid any dele prehensive multisystem assessment and the treatment
terious effects on the patient's overall condition. goals for a given patient. If the acute effects of mobi
Frequent ambulation constitutes preventive exer lization or exercise on oxygen transport are indicated,
cise. Provided the patient does not require undue the prescription specifies the parameters of an appro
monitoring and has been cleared as a risk, preventive priate mobilization or exercise stimulus, lIsually, of
exercise can be encouraged by all team members. relatively low intensity, shOtt duration and high fre
This role of exercise is quite distinct and separate quency. The treatment effects are often immediate.
from the therapeutic interventions of mobilization Because treatment responses can be dramatic, the
and exercise for their specific acute and long-term ef prescription is progressed relatively quickly based on
fects that are prescribed for the remediation of acute the treatment response measures. Prescribing mobi
and chronic cardiopulmonary dysfunction. The appli lization to remediate acute cardiopulmonary dysfunc
cation of mobilization and exercise for optimizing tion requires the same precision and specificity as
oxygen transpott is the specific expertise and within prescribing exercise for chronic cardiopulmonary
the unique domain of the PT. dysfunction. If the long-term effects of exercise are
indicated, the exercise stimulus is defined in an ap
propriate prescription, i.e., generally higher intensity,
ASSESSMENT OF MOBILIZATION
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296 PART III Cardiopulmonary Physical Therapy Interventions
sufficient intensity, duration, and frequency, to pre Borg, G. (1982). Psychophysical basis of perceived exertion. Med
ical Science in Sports and Exercise, 14, 377-381.
serve adequate aerobic capacity and endurance for a
Borg, G.A.V. (1970). Psychophysiological bases of perceived
given patient. The principles for prescribing mobi
exertion. Scandinavian Journal of Rehabili/ation Medicine.
lization and exercise for their optimal preventive ef 2, 92-98.
fects have not been scientifically elucidated. These Browse, N.L. (1965). The Physioiogy lind Pa/hol08Y of Bed Res/.
three levels of prescription of mobilization and exer Springfield,1I1.: Charles C. Thomas. Publisher
cise are physiologically distinct and need to be pre Bydgeman, S., & Wahren, J. (1974). Influence of body position on
the anginal thr shold during leg exercise. European Journal of
scribed specifically for each patient.
Clinical lnves/igation, 4. 201-206.
Cardus, D. (1967). 02 alveolar-arterial tension dirferences after 10
days' recumbency in man. Journal (j( Applied Physiology, 23,
REVIEW QUESTIONS
934-937.
I. Distinguish between mobilization and exercise. Chase, G.A., Grave, c., & Rowell, L.B. (1966). Independence of
changes in functional and performance capacities attending
2. Distinguish among the prescription of mobiliza
prolonged bed rcst. Aerospace Medicine. 17, 1232-1237.
tion/exercise for its acute effects, chronic effects, Chobanian, A.V., Lillc, RD., Tercyak,A., Blevins, P (1974). The
and preventive effects. metabolic and hemodynamic cfT('cts of prolonged bed rest in
3. Describe the differences in the mobilization/ex normal subj ects . Circulation, 49. 551-559.
ercise prescription parameters (i.e., type of exer Clauss, R.H., Scalabrini, B.Y . , Ray,J.F., & Reed, G.E. (1968) Ef·
fects of changing body positions upon improved ventilation
cise stimulus, intensity, duration, frequency, and
perfusion relationships. Circula/ion. 37 (SuppI4). 214-217.
course) when prescribing mobilization/exercise Compton, D.M., Eisenman, P.A., and Henderson, H.L. (1989). Ex
for its (l) acute effects, (2) chronic effects, and ercise and fitness for persons with disabilities. Sports Medicine,
6. Describe the negative sequelae of restricted change in the seated and supine positions. Journal of Applied
Physiology, 31, 717-721.
mobility.
Dean, E. (1993). Advance.s in rehabilitation for older persons with
cardiopulmonary dysfunction. In: Advances ill Long-Term
Care. Katz, P.R., Kane, R.L., & Mezey, M.D. (eds.). New
References
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Ahlinder, S., Birke, G., Norberg, R., Plantin, L.O., and Reizen Dean, E., Murphy, S, Parrent, L, and Rousseau, M. (1995). Meta
stein, P. (1970). Metabolism and distribution of IgG in patients bolic consequences of physical therapy in critically-ill patients.
confined to prolonged strict bed rest. ACTa Medica Scandinav Proceedings of the World Confederation of Physical Therapy
American College of Sports Medicine (1994). Guidelines for Exer Dean, E., & Ross, J. (1992a). Mobilization and exercise condi
cise Testing and Prescription (6th cd.). Philadelphia: Williams tioning. In: Zadai, C (Ed). Clinics in Physical Therapy. Pul
Andreoli, K.G., Fowkes, V.K., Zipes, D.P., & Wallace, A.G. Churchill Livingstone.
(eds.). (1991). Comprehensive Cardiac Care (7th ed.). St. Dean, E., & Ross, J. (1992b). Discordance between cardiopul
Belman, M.J.,& Wasserman, K. (1981). Exercise training and test basis for praclice. Chest, 101, J 694-1698.
ing in patients with chronic obstructive lung disease. Basics of Dean, E., & Ross, J. (1993). Movement energetics of individuals
Respiratory Disease, 10, 1-6. with a history of pOliomyelitis. Archives of Physical Medicine
Blair, E., & Hickman, J.B. (1995). The effect of change in body alld Rehabilitation, 74, 478-483.
position on lung volumes and intrapulmonary gas mixing in Deitrick, J.E., Whedon, G.D., & Shorr, E. (1948). Effects of immo
normal subjects. Journal of Clinical Investigation, 34, 383-389. bilization upon various metabolic and physiologic functions of
Blair, S.N., Painter, P., Pate, R.R., Smith, L. K., & Taylor, C.B. normal man. American Journal of Medicine, 4, 3-36.
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Testing and Training. Philadelphia: Lea & Febiger. of the American Medical Association, 125. 1083- J 085.
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Donaldson, CL.. Hulley, S.B., & McMillan A.V. (1969). The ef Risser, N.L. (1980). Preoperative and postoperative care to prevent
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Hsu, H.O., & Hi c kcy. R.F. (1976). Effect of posture on funct ional Sandlcr, H, Popp, R.L., & Harrison, D.C (1988). The hemody
residual capacity postoperatively. Anesthesiology, 44, 520-521. namic effects of repeated bed rest exposure. Aerospace Mecli
Hulley, S.B .. Vogcl. J.M. Donaldson, CL., Bayers, J.M., Fried cine, 59,1047-1053.
man, R.J .. & Rosen, S.N. (1971). The effect of supplemental Schimmel, L., Civetta, J.M., & Kirby, R.R. ([977). A new me
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bedrcst. Journal of Clinicul Investig{/tiol7, 50, 2506-2518. ill patients. Critical Care Medicine, 5,277-279.
Jrwin, S., & Tecklin, J.S. (eds.). (1985). Cardiopulmonary Physi Shepherd, RJ., et al. Standardization of submaximal exercise test.
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(1978). Dyspnea, disability, and distance walked Comparison Underhill, S.L., Woods, S.L., Froelicher, E.S.S., & Halpenny, CJ.
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298 PART III Cardiopulmonary Physical Therapy Interventions
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Copyrighted Material
Body Positioning
Elizabeth Dean
INTRODUCTION
prescriptions, because no specific patient is being con
The purpose of this chapter is threefold. First, thera sidered. Understanding the physiological effects of
peutic body positioning, which is prescribed to opti body position on oxygen transport and how patho
mize cardiopulmonary function and oxygeQ transport physiology disrupts these normal processes is funda
is differentiated from routine dY'l'ositioning. Sec mental to prescribing body positioning. However, an
ond, the physiological effects of different body posi optimal body position can only be prescribed based on
tions and changing body positions on cardiopulmonary consideration of all the factors that impact on oxygen
function and oxygen transport, are described. And transport, that is, effects of the patient's pathophysiol
third, the prescription of therapeutic body positioning ogy and its specific presentation in that individual, the
is described. Body positions that simulate normal effect of immobility, the effect of extrinsic factors re
physiological effects of gravity and position change on lated to the patient's care and the effect of intrinsic
oxygen transport are the priority, that is, being upright factors related to the patient (Chapter IS). It is only by
and moving. A hierarchy of body positions ranging an integrated analysis of these factors collectively that
from the most to the least physiological is presented. (1) the most beneficial body positions can be pre
This chapter concentrates on the principles of pre dicted, (2) the least beneficial body positions can be
scribing therapeutic body positioning and body posi identified and used minimally, and (3) the appropriate
tion changes. The chapter does not provide treatment treatment outcome measures can be selected.
299
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O
300 PART III Cardiopulmonary Physical Therapy Interventions
7
reduced, or avoided the singlemost important objec 1'0
tive of cardiopulmonary physical therapy.
A patient is continually exposed to gravity, thus
every position the patient assumes reflects the effect of FIGURE 18-1
Regional physiologic differences down the upright lung.
gravity on oxygen transport, thus, oxygen transport can
VA alveolar ventilation, Q perfusion, V NQ
be improved, maintained or worsened with changes in
= = =
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18 Body Positioning 301
ous effects of prolonged periods in a single position deleterious to oxygen transport. The side-lying positions
supports the prescription of both frequent body posi have an effect that is intermediate between upright and
tion changes and extreme consecutive body positions. supine. The prone position which is under utilized clini
These perturbations simulate the nOimal perturbations cally, has such a significant beneficial effect on oxygen
that the cardiopulmonary and cardiovascular systems transport that a good rationale should be made for not
are exposed to in health during normal mobility and incorporating this position into the treatment prescrip
body position changes. The ability to weigh the rela tion rather than for using this position.
tive beneficial and deleterious effects of each possible The indications for therapeutic body positioning
body position, that is, over 360 degrees in the horizon and the indications for frequent body position changes
tal plane and 180 degrees in the vertical plane (ranging to optimize oxygen transp0l1 are shown in the boxes
from 20 degrees head down to 20 degrees lean for on pp. 302-303. For each of the indications listed, an
ward) on a given patient's gas exchange, is critical in optimally therapeutic body position can be selected
prescribing body positioning therapeutically. for a given patient. A description of the physiological
effects of several primary body positions follow,
namely, the upright supine, side lying, head down,
PRESCRIPTIVE VS. ROUTINE BODY POSITIONING
and prone positions. This information, howevcr, can
The literature supports the benefits of frequent body po not be applied out of context. The specific positions
sition changes particularly for the patient who is rela prescribed for a patient are based on a consideration
tively immobile, severely debilitated, obtunded, breath of the multiple factors that impair oxygen transport
ing at low lung volumes, obese, aged, very young or (Chapter 16) in conjunction with a physiological
who has lost the sigh mechanism. The practice of rou analysis of the most justifiable positions.
tinely turning patients every 2 hours is widely accepted. Because of the potent and direct effects of body po
This practice is based on the belief that the deletelious sitioning on various steps in the oxygen transport path
consequences associated with assuming a static posi way in health and in disease, it is unknown whether the
tion for a prolonged period will be prevented. Recent beneficial effects reported with the use of postural
evidence, however, supports that more frequent turning drainage are attributable to enhanced mucociliary
can have greater physiological benefits in criticaJiy ill transport, or to the direct effect of positioning the good
patients (Dean and Suess, 1995) which suggests less se lung down on improving the gas exchange of that lung,
verely ill patients may also benefit. The preventive ef by increasing alveolar volume of the affected, nonde
fects of a routine turning regimen are distinct from the pendent lung, or both. Typically, studies evaluating
acute effects of body positioning on oxygen transport conventional chest physical therapy, including postural
which is the primary focus of this chapter. drainage, have failed to control for the direct effect of
body positioning on cardiopulmonary function, or for
the direct effects of increased arousal and mobilization
PHYSIOLOGICAL EFFECTS OF
that occur when changing a patient's body position
DIFFERENT BODY POSITIONS
(Dean, 1994a). This is an extremely serious method
Body positioning has potent and direct effects on most ological problem that pervades the literature evaluating
steps of the oxygen transport pathway, thus can be pre conventional chest physical therapy, and one that
scribed to elicit these effects specifically. Because hu needs to be considered when interpreting the results of
mans function optimally when upright and moving, studies on these procedurers. Unless these potent con
therapeutic interventions that elicit or simulate being founding variables are controlled, the degree to which
upright and moving (i.e., elicit both gravitational and conventional chest physical therapy had a beneficial
exercise stress) are most justified physiologically. The effect over and above the effects of positioning as well
recumbent supine position, a common position assumed as mobilization and increased arousal cannot be deter
by hospitalized patients, is nonphysiological, therefore mined (Dean, I 994b).
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302 PART III Cardiopulmonary Physical Therapy Interventions
i Regional ventilation
Cardiovascular
i Regional perfusion ..l. Preload and afterload
i Regional diffusion
..l. Work of the heal1
Optimize area of optimal ventilation to perfusion
Improve systolic ejection fraction to pulmonary and
matching
systemic circulations
..l. Pulmonary shunting Alter venous return
i Lung volumes and capacities particularly, functional
..l. Gravitational. mechanical a n d compression
residual capacity, vital capacity and tidal volume
forces on the myocardium. great vessels, medi
..l. Closure of dependent airways astinal structures. and lymphatic system
Alter breathing frequency Optimize t1uid shift from central to dependent areas
(extremities) and vice versa to maintain nuid vol
Alter minute ventilation
ume regulating mechanisms
Alter position of the hemidiaphragms
Other Systemic Effects
i Respiratory muscle efticiency
Optimize chest tube drainage
..l. Airway resistance
Facilitate urinary drainage
i Lung compliance
Reduce posturally increased muscle tone
i Air now rates
Facilitate patient arousal
Stimulate cough
Promote relaxation
i Biomechanical efficiency of cough, its strength
and productivity Promote comfort
Improve arterial blood gases, gas exchange and oxy Promote biomechanically optimal body positions
genation
lntraabdominal pressure
i Mucociliary transpOit and mucus clearance Intracranial pressure
..l. Gravitational, mechanical and compression forces
on the lungs, chest wall, diaphragm and the gut
Upright Positions
exercise stimulus. The upright standing position max
The physiological position for the human organism is imizes lung volumes and capacities with the excep
the same as the anatomical position-upright. The tion of closing volume, which is decreased (Svan
upright positions include walking, standing, and sit berg, 1957). Functional residual capacity (FRC), the
ting. The upright position coupled with movement volume of air remaining in the lungs at the end of a
(e.g., walking and cycling) optimizes oxygen trans normal expiration, is slightly greater in standing com
port to the greatest degree in that ventilation and per pared with sitting and exceeds that in supine by ap
fusion are more uniform than without the additional proximately 50% (Figure 18-2). Maximizing FRC is
Copyrighted Material
18 Body Positioning 303
Alter chest wall configuration cause of age-related changes, closing capacity of the
dependent airways increases with age; this effect is
Shift distribution of alveolar volume
further accentuated with recumbency. Airway closure
Shift distribution of ventilation
is evident in supine in the healthy 45-year-old person,
Shift distribution of perfusion
and in the upright position in the healthy 65-year-old
Shift distribution of diffusion person (Leblanc, Ruff, and Milic-Emili, 1970). These
Shift distribution of ventilation to perfusion matching effects are further accentuated in patient populations,
Shift mechanical physical compression of the heart thus the upright position is favored and the supine po
on adjacent alveoli sition should be minimized to prevent airway closure
Shift position of the heart thereby alter chamber end and impaired gas exchange.
disastolic filling pressures. preload, afterload, and With respect to pulmonary function testing, the up
work of the heart right sitting position with legs dependent is the stan
Shift distribution of mucus transport and accumulation dard reference position (American Thoracic Society,
Stimulate effective and productive cough 1987). When upright, the diameter of the main air
ways increases slightly. If the airways are obstructed
Facilitate lymphatic drainage
even small degrees of airway narrowing induced by
Perturb pattern of monotonous tidal ventilation
recumbency can result in significant airway resistance
Alter breathing pattern
(Figure 18-4). The vertical gravitational gradient is
Shift gravitational, mechanical and compression forces maximal when upright, the anteroposterior dimension
on the lungs, chest wall. diaphragm, and the gut
of the chest wall is the greatest, and compression of
Simulate normal inflation-deflation sigh cycles the heart and lungs is minimal (Weber, Janicki,
Shift intraabdominal pressure Sllroff, and Likoff, 1983). The shortened position of
the diaphragmatic fibers is countered by an increase in
Cardiovascular
the neural drive to breathe in the upright position
Shift gravitational. mechanical, and compression
(Druz and Sharp, 1982).
forces on the myocardium, great vessels. medi
astinal structures. and lymphatic system The distribution of ventilation is determined pri
ll)arily by the effect of gravity, which changes down
Stimulate fluid volume shifts particularly to the de
pendent limbs the lung due to the anatomical position and suspen
sion of the lungs within the chest. At FRC in the up
Other Systemic Effects
right position, the intrapleural pressures at the apex is
Optimize chest tube drainage
-10 cm H20 and at the base -2.5 cm H20 (Figure 18
Promote urinary drainage 5). The intrapleural pressure is less negative in the
Shift abnormal postural tone patterns base because of the weight of the lung. Because of
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304 PART III Cardiopulmonary Physical Therapy Interventions
3.5
'u
'"
c.
B 3.0
'"
:l
1:>
'v;
'" 2. 5
c
.9
U
c
:l
u..
2.0
Bars indicate
FIGURE 18-2
Changes in functional residual capacity in various body positions. (Data reprinted with permission
from Nunn JF: Applied respiratory physiology, London, 1987, Butterworths.)
FRC upright
3
FRC supine
'"
..
!; 2
..
E
.2
o
:>
at
c
:l
-'
30 40 50 60 70
Age yearsl
FIGURE 18-3
Functional residual capacity (FRC) and closing capacity as a function of age. (Data reprinted with
permission from Nunn JF: Applied respiratory physiology. London, 1987, Butterworths.)
Copyrighted Material
18 Body Positioning 305
-10 em H20
Erect Supine
Intrapleural
pressure
Bronchus
100%
<1l
Mucus
50% §
FIGURE 18-4
Effect of body position on bronchiolar diameter. (Reprinted
with permission from Browse NL: The physiology and
+10 o
pathology of bed rest, Springfield, III. 1965, Charles C.
Thomas.)
Intrapleural pressure (cmH20)
FIGURE 18-5
A common clinical concern is the patient breathing Schematic of the regional differences in ventilation down
at low lung volumes (e.g., the patient in pain, the sur the upright lung. (Reprinted with permission from West 18:
gical patient with thoracic or abdominal incisions, Ventilation! bloodflow and gas excfumge, ed 4, Ox ford,
older and younger patients, obese patients, pregnant 1985, Blackwell Scientific.)
Copyrighted Material
306 PART III Cardiopulmonary Physical Therapv Interventions
of intrathoracic pressure and re- the recruitment of pulmonary vessels. Arterial pres
venous return and cardiac output. These fac sure exceeds alveolar pressure and blood flow. Zone
tors in addition to the pressure to 3, in the lower area of the reflects the blood
open the valve can increase the work of flow from the distension of pulmonary vessels; arter
associated with mechanical ventilation ial and venous pressures exceed alveolar pressure.
and 1990; zone 4 in the most
Arcos, and Hiriart, 1984). of the has minimal to no pulmonary
gravity is the primary determinant of in blood flow because of interstitial pressure acting on
differences in the distribution of ventila the pulmonary blood vessels a compression
tion in the lung, imrareg ional force 1995).
secondary to differences in and resistance Ventilation (V) and (Q) matchl!1g re-
of lung also contribute of the distributons of V and Q
and Abboud, 1992). These effects are eXa)!,)!,CI Both V and Q increase down
populations (989). V increases disproportion
The distribution of perfusion down the upright ately more than Q 18-8). As a the
lung is also gravity (Figure 18- mal area for VIQ matching is in the mid zone where
The pressures affecting blood flow through the the ratio is about 1.0 (West,
pulmonary capillaries and in the un The uoril!ht position is associated with
even distribution of blood flow are alveolar pressure, effects. These effects reflect primarily
and the arterial and venous pressures. Zone 1, at the the central blood volume that is shifted from the tho
apex, alveolar pressure predominates arterial and ve racic compartment to the dependent venous compart
nous pressures, thus has minimal to no blood flow. ments on the position from
Zone 2, in the reflects the blood flow from (Blomqvist and Stone, Gauer and Thron,
---+
FIGURE 18-7
Schematic of pressures affecting the pulmonary and blood flow. (Reprinted with
permission from West 1B: VentilaliOIl/bloodjlolV and gas exchange, ed 4, Ox ford, 1985,
Blackwell
Copyrighted Material
18 Body Positioning 307
15
I/minute 3
% Lung volume
Blood flow
10
2
Ventilation
05
Rib number
BaHam Top
FIGURE 18-8
Distributions of ventilation and blood flow down the upright lung and the distribution of ventilation
perfusion matching down the upright lung. (Reprinted with pennission from West JB:
Ventilationlbloodflow and gas exchange, ed 4, Oxford, 1985, Blackwell Scientific.)
/
5° 15° °
4 45
Blood
flow 4
ml/minute/
1 00 m l
3
,
,
2
Calf Ai ,
0'
Foot
FIGURE 18-9
Effect of body position on peripheral blood flow. (Reprinted with permission from Browse NL:
The physiology and pathology of bed rest, Springfield, 111., 1965, Charles C. Thomas.)
Copyrighted Material
308 PART III Cardiopulmonary Physical Therapy Interventions
Erect Supine
Stagnant area
FIGURE 18-10
Effect of body position on drainage from the pelvis of the kidney. (Reprinted with permission from
Browse NL: The physiology and pathology of bed rest, Springfield, III., 1965, Charles C. Thomas.)
Supine Position
Sandler, \986). End diastolic and stroke volumes are
decreased, which results in a compensatory increase The supine position is clearly not a physiological
in heart rate (Thandani and Parker, 1978). Cardiac position for humans unless sleeping, and is physio
output is correspondingly decreased. The net effect of logically the least justifiable position for ill patients
these physiological changes is a reduction in myocar regardless of whether they exhibit cardiopulmonary
dial work (Langou, Wolfson, Olson, and Cohen, dysfunction (Dock, 1944; Moreno and Lyons, 1961;
1977). This finding in corroborated by the observation Powers, 1944; Winslow, 1985). The nonspecific use
that anginal threshold is increased in cardiac patients and overwhelming acceptance of bed rest has devel
in this position (Prakash, Parmely, Dikshit, Forrester, oped historically over the past 130 years. In the
and Swan, 1973). Peripheral vascular resistance in mid-1800s, that internal organs could be rested as a
creases and blood flow decreases, with the assumption therapeutic intervention comparable with immobi
of the upright position greater than 45 degrees to off lizing and resting injuries of the limbs was the pre
set dependent fluid shifts and potential blood pressure vailing medical philosqphy. The injudicious appli
drop (Figure 18-9). Another important effect of body cation and overuse of bed rest to cure all medical
position on fluid volume is the promotion of urinary problems was critically challenged by Harrison
drainage from the renal pelvi to the bladder in the up (1944) and Browse (1965). Although there has been
right positions as a result of the reduced area for uri a significant decrease in use of prolonged periods of
nary stasis in this position compared with supine (Fig bed rest based on innumerable studies of the nega
ure 18-10). Optimal renal function is essential in tive sequelae of bed rest over t h e past several
preserving normal hemodynamic status. decades (Dean and Ross, 1992b), the merits of bed
Copyrighted Material
18 Body Positioning 309
o 0
0,
,
as any medication.
The supine position alters the chest wall configu :.
:.. .:-
ration, the anteroposterior position of the hemidi : "," . .:::.'.
aphragms, the intrathoracic pressure, and the intraab
dominal pressure secondary to the shifting of the
abdominal viscera in this position (Behrakis, Baydur, FIGURE 18-11
Jaeger, and Milic-Emili, 1983; Craig, Wahba, Don, Effect of body position on the distribution of mucus within
the bronchi. (Reprinted with permission from Browse NL:
Couture, and Becklake, 1971; Don, Craig, Wahba,
The physiology and pathology of bed rest, Springfield, IJI.,
and Couture, 1971; Druz and Sharp, 1981; Klingstedt
1965, Charles C. Thomas.)
et ai, 1990; Roussos, Fukuchi, Macklem, and Engel,
1976; Saaki, Hida, and Takishima, 1977). The normal
anteroposterior configuration becomes more trans
verse. The hemidiaphragms are displaced cephalad, Several significant cardiovascular changes occur
which significantly reduces FRC in this position (Hsu on assuming the supine position. A central shift of
and Hickey, 1976). Excess secretions tend to pool on blood volume from the extremities to the central cir
the dependent side of the airway. Thus the upper side culation initiates orthostatism (Sandler, 1986). This
may dry out, exposing the patient to infection and ob fluid shift increases both the preload and afterload of
struction (Fig. 18-11). the right side of the heart. This increased volume
An increase in intrathoracic blood volume also tends to distort the interventricular septum, and re
contributes to a reduction in FRC, lung compliance, duces left ventricular volume and preload. Prefaut
and increased airway resistance in the supine position and Engel (1981) observed that hypoxic vasocon
(Nunn, 1987; Sjostrand, 1951). Collectively, these ef striction secondary to closure of the dependent air
fects predispose the patient to airway closure and an ways in the supine position contributed to preferential
increase in the work of breathing. Although a healthy perfusion of the nondependent lung zones. The rela
person can accommodate to these physiological tively increased central blood volume inhibits the re
changes, a healthy person does not assume this posi lease of antidiuretic hormone. Ten to 15 percent of
tion for prolonged periods without shifting. A hospi fluid is lost within 24 hours (Sandler, 1986), which
talized patient, however, is less likely to adapt to these can manifest clinically as cardiac underfilling, ortho
immediate changes and their long-tenn effects. In ad static intolerance, and a negative fluid balance (Dean
dition, they may be less responsive to the need to shift and Ross, 1992a).
position or unable to respond to afferent stimuli Because of a reduction in the vertical gravitational
prompting a need to change position. These effects are gradient, and therefore the intrapleural pressure gra
accentuated in older people whose arterial oxygen ten dient of the lung in supine, the distribution of V/Q
sions progressively diminish with age (Ward, Tolas, matching appears more uniform and evenly matched
Benveniste, Hansen, and Bonica, 1966; Nunn, 1987). in the supine position (Bates, 1989). These changes,
Copyrighted Material
310 PART III Cardiopulmonary Physical Therapy Interventions
Erect Supine
cm
Above 20
iliac
crest
15
FIGURE 18-12
Effect of body position on the level and movements of the diaphragm during respiration.
(Reprinted with permission from Browse NL: The physiology and pathology of bed rest,
Springfield. Ill., 1965, Charles C. Thomas.)
I
I
1.:-
I.::'
/':-:
,..:-::-
L:':
:: r:-::::,:
(: :' :
Awake spontaneous
:':
r::::'
j
-:
.:- -.,
·:':::i
/ · 7':
>1
.... f
/ : <
nn n\n
nnnqn ___
Paratyzed
Anasthelized spontaneous
FIGURE 18-13
Position of the diaphragm in an awake spontaneously breathing subject, and in an anesthetized
subject with and without paralysis. The broken line is the end-expiratory position of the diaphragm
in the awake state in the supine position. The shaded area shows the excursion of the diaphragm
during inspiration and expiration.
(From Froese AB, Bryan AC: Effects of anesthesia and paralysis on diaphragmatic mechanics in
man. Anesrhesio[ogy 41 :242-255.)
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18 Body Positioning 311
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312 PART III Cardiopulmonary Physical Therapy Interventions
contributes to an improved V IQ matching. These ap those with respiratory muscle fatigue may have in
parent improvements, however, are offset by reduced creased respiratory distress in this posi tion due to
lung volumes and air flow rates in this position. the resistive loading of the diaphragm from the
In both healthy people and patients, arterial oxy weight of the viscera beneath.
gen tension is greater in side lying compared with
supine (Clauss, Scalabrini, Ray, and Reed, 1968).
Prone Position
This is true both for patients receiving supplemental
oxygen as well as those who are not. Thus sidelying There is considerable physiological justification for
can be used to enhance the efficiency of oxygen the use of the prone position to enhance arterial oxy
transport and thereby minimize or avoid the use of genation and reduce the work of breathing in patients
supplemental oxygen. Arterial blood gases are im with cardiopulmonary dysfunction. Specifically, the
proved in patients with unilateral lung disease (Re prone position increases arterial oxygen tension, tidal
molina, Khan, Santiago, and Edleman, 1981; Sonnen volume and lung compliance (Albert, Leasa, Sander
blick, Meltzer, and Rosin, 1983) when positioned son, Robertson, and Hlastala, 1987; Schwartz, Fen
with the good lung down and worsened with the af ner, and W o lfsdorf, 1975; Wagaman, Shutack,
fected lung down. When lung pathology is bilateral, Moomjiam, Schwartz, Shaffer, and Fox, 1979). These
arterial blood gases are improved when patients lie benefits have also been observed in critically ill pa
on the right side compared with the left. This can be tients (Langer, Mascheroni, Marcolin, and Gattinoni,
explained by the greater size of the right lung and the 1988). In one study (Douglas, Rehder, Beynen,
reduced compression of the heart on the lung in this Sessler, and Marsh, 1977), supplemental oxygen was
position compared with left side lying (Dean, 1985; reduced in four out of five mechanically ventilated
Zach, Pontoppidan, and Kazemi, 1974). patients whose positioning regimen included the
prone abdomen-free position. The two common vari
ants of the prone position are prone abdomen-re
Head Down Position
stricted and abdomen-free. Prone abdomen-restricted
The head down position augments oxygen transport refers to lying prone with the abdomen in contact
in some palients by improving pulmonary mechan with the bed, whereas in the prone abdomen-free po
ics. Patients with chronic airflow limitation, for ex sition the patient's hips and chest are elevated so that
ample, tend to have hyperinflated chests and flat the abdomen is free.
tened diaphragms in which the contraction of the W h i le both prone positions augment gas ex
diaphragm is inefficient because of the position of change, the prone abdomen-free position, comparable
its muscle fibers on the length tension curve. The with the hands and knees position (Mellins, 1974),
head down position causes the v iscera to be dis enhances lung compliance, tidal volume, FRC and di
placed cephalad beneath the diaphragm. The di aphragmatic excursion to a greater degree. Although
aphragm is positioned more normally and rests at a patients in respiratory failure have been shown to
higher and more mechanically efficient position in benefit significantly from the prone position, certain
the chest (Barach and Beck, 1954; De Troyer, precautions must be observed. The patient must be
1983). In this position, patients may experience re positioned so that all pressure points particularly on
lief from dyspnea, reduced accessory muscle use, the head and face, and stress on the mechanical venti
reduced upper chest breathing patterns and reduced lator tubing and circuitry is minimized. The patient
minute ventilation. Patients with pathology to the should be monitored continuously and not be unat
bases may also benefit from the head down position tended. A semiprone position can provide many of
in that this position favors gas exchange in the more the physiological benefits of a full prone position,
functional upper lung fields and promotes alveolar and minimize some of the risks, particularly in me
distension of bases, which are uppermost in the head chanically ventilated patients and patients with cervi
down position. Other patients, however, such as cal spine pathology. In addition, the semiprone posi
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18 Body Positioning 313
tion simulates the prone abdomen-free position. The constituent distributions of ventilation, perfusion, and
scmiprone position may be more conservative, safer, ventilation and perfusion matching. Areas of depen
and comfortable for the patient who is severely ill, dent atelectasis, physiologic dead space and shunting,
potentially hemodynamically unstable, older, or who and mucus distribution are dramatically shifted. The
has a protruding abdomen. "stir-up" correspondingly s t i mulates lymphatic
For patients who are not able to be effectively mo drainage, surfactant production and distribution, and
bilized some variant of the 'prone position is even the distribution and function of pulmonary immune
more important. Excessive recumbency, particularly factors (Pyne, 1994). Frequent physical perturbations
in patients who are being positioned through a re also inhibit bacterial colonization (Skerrett, Nieder
stricted arc (e.g., supine and one-quarter turns to ei man, and Fein, 1989). F r e q u e n t b o d y position
ther side) needs to be offst by some variant of the changes redistribute compression forces acting on the
prone position and this position needs to be incorpo diaphragm, myocardium, and mediastinal structures,
rated often. [nevitably, patients exposed to a re and the compression of the lungs by the myocardium
stricted arc of positioning will develop atelectasis in and mediastinal structures.
the dependent lung fields. The only means of pre Frequent body position changes have significant
venting and countering compression and hydrostati effects on stimulating the patient and increasing
cally induced atelectasis is by placing those depen arousal and a more wakeful state (Figure 18-15). The
dent areas uppermost. more upright the patient is positioned the greater the
The time course for the development of such hy neurological arousal and greater the stimulus to
drostatic complications is dependent on the patient. breathe; this effect is augmented by encouraging the
Although objective measures of oxygen transport and patient to be self-supporting. Concomitant with an in
the adequacy of the steps in the oxygen trans[lort path crease in arousal, the patient is stimulated to take
way are essential to monitor, functional changcs will deeper breaths, and hence increase alveolar ventila
likely precede the appearance of objective changes. tion. When body positioning is coupled with mobi
lization, vasodilatation, and recruitment of the pul
monary capillaries is stimulated, which in turn
PHYSIOLOGIC EFFECTS OF FREQUENT
improves the even distributions of ventilation and
CHANGES IN BODY POSITION
perfusion, and hence augments VIQ matching.
The box on p. 303 lists some of the significant physi
ological effects of frequent changes in body position
PRESCRIPTION OF THERAPEUTIC BODY POSITIONS
that are largely mediated through their effects on res
AND BODY POSITION CHANGES
piratory mechanics, cardiac mechanics, airway clo
sure, mucociliary transport, lymphatic drainage, and Prescription of body positioning is based on an analy
altered neural activation of the diaphragm. These ef sis of the factors that contribute to impaired oxygen
fects resulting from the changc in position are distinct transport. Specific positions are selected to simulate
from the benefits derived from a particular body PoS! as closely as possible the physiologic function of the
tion. The benefits of changing position can be en normal healthy upright cardiopulmonary unit, and the
hanced by moving to an extreme position, ie, moving perturbations and "stirring up" that occurs in the car
from supine to prone compared with supine to side diopulmonary system during normal mobility and
lying. Extreme body position changes simulate, but being upright. A hierarchy of body positioning alter
do not replace, the physiological "stir-up" and pertur natives based on the physiologic justification of the
bations that occur with normal mobility and being various positions, appears in the box on p. 3 14. These
upright. When the "stir-up" regimen was originally positions range from the most to the least physio
proposed, Dripps and Waters ( 1941) did not appreci logic. The hierarchy is based on the premise that oxy
ate fully its physiological implications. The net effect gen transport is optimal when upright and moving.
of changing body position is a "stirring up" of the Mobilization in the upright position increases tidal
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314 PART III Cardiopulmonary Physical Therapy Interventions
Normally moving upright in a I G gravitational field and exposed to a range of body positions and body position
changes over the course of several hours
Erect sitting (self supported or with assist) with feet moving (e.g., active, active assisted or passive cycling motion)
Supine
The less able the patient is to assist in positioning the greater the need for more extreme positions and greater the
turning frequency.
If the patient is totally unable to move, that is, in coma or paralyzed, extreme body positions arc also indicated if not
contraindicated because of hemodynamic instability or increased intracerebral pressure. The upright position is
used as much as possible provided the patient is physically supported for safety and monitored in terms of treat
ment response. Passive standing on a tilt table is hemodynamically questionable; preferably patients should be
placed in a high Fowler's position with legs positioned dependently using the knee breaks in the bed.
Regimens of 360-degree horizontal tuming and ISO-degree vertical turning (ranging from 20 degrees head down to
20 degrees lean forward) are used unless contraindicated. Positioning through a maximal arc simulates as closely as
possible three dimensional movement of the chest wall during normal respiration.
volume, respiratory rate, and hence minute volume, right state. Furthermore, even the mobilized patient
flow rates, mucociliary transport, and clearance, and can benefit from therapeutic body positioning be
enhances the efficiency and effectiveness of airway tween mobilization sessions.
clearance and coughing. Thus incorporating active Body position needs first to be exploited when
movement into the body position change is optimal. coupled with movement followed by the erect sitting
Despite the well-documented benefits of the judi positions with legs dependent. Figure 18-16 illus
cious application of therapeutic body positioning to trates several variants of the sitting position. Each of
enhance oxygen transport, it does not replace the these positions has distinct effects on oxygen trans
more physiological intervention of mobilization and port, thus the specific upright position has to be pre
exercise to maximize oxygen transport. Rather, once scribed specifically as the supported and "propped
the effects of mobilization/exercise have been ex up" positions in bed do substitute for upright erect
ploited maximally, then body positioning is the next sitting. These variants only have a role when the pa
best physiological approximation to a mobilized up tient will deteriorate by attempting to position in the
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18 Body Positioning 315
Aroused Asleep
Cortical
activating
impulses
FIGURE 18-15
Effect of arousal on cerebral activity. (Reprinted with permission from Browse NL: The physiology
and pathology of bed rest, Springfield, III., 1965, Charles C. Thomas.)
upright erect position, or the patient immediately de prone or semiprone positions. Patients can be posi
teriorates once in the position. Sitting with the feet tioned safely, with appropriate supervision and moni
down is preferable to long sit because of the hemody toring, and comfortably in these full positions by ob
namic benefits associated with this position. Sitting serving the normal precautions of passive positioning.
up in bed fails to position the patient in a perfectly A common practice is to progressively turn pa
vertical upright position. Fowler's position in bed can tients in one-quarter turns, such as supine to side
be maximized and the use of knee breaks in the bed lying and back to supine and so forth. However, the
provides a gravitational stimulus to the circulating use of extreme positions and extreme position
blood volume. changes may yield greater benefit with respect to the
A major difficulty with positioning patients in bed is degree of perturbation and "stir-up" elicited (Piehl
the tendency to lose the position. Patients lose optimal and Brown, 1977). Extreme position changes result in
positions in bed very quickly and thus need to be moni significant alterations in the distributions of V, Q,
tored to ensure the specific positions are maintained. and V and Q matching. Mucociliary transport is stim
Pillows should not be used to maintain a body position, ulated, and secretion accumulation and stagnation is
since these are easily compressed and shifted. Blankets minimized. In addition, the more extreme the body
and sheets tightly rolled and secured with tape, and spe position, the greater degree of arousal stimulated par
cially made bolsters are considerably more effective in ticularly in the upright positions, which is essential in
maintaining a patient's body position. critically ill patients.
Although there is a role for modified positions, Another impo r t a n t consideration is the time
such as half side lying these positions are often course of changes in ox.ygen
overused at the expense of full turns to each side, or and position changes. There are three plausible out
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316 PART III Cardiopulmonary Physical Therapy Interventions
f=4
son, Tonnesen, 1988; Gonzalez-Arias, Goldberg,
Supine Baumgartner, Hoopes, and Rubin, 1983; Kelley,
Vi b u l srest, Bell, a n d D u n c a n, 1987; Mein ig,
Leininger, and Heckman, 1986; Summer, Curry,
Haponik, Nelson, & Elston, 1989). These beds are in
HI
dicated for patients who are moderately hemodynami
Recumbent cally u nstable and on neuromuscular blockers, and
thus tolerate manual turns poorly. Such turning frames
are contraindicated, however, for patients who are less
ill. Even for those patients who require multiple assis
h
tants and extra caution and time to turn and position
Propped-up effectively, these issues should never deny a patient a
much needed treatment with proven efi'icacy.
The benefit of these beds on oxygen transport in
hi
critically ill patients has implications for the manage
ment of less critically ill patients. The continuous me
FIGURE 18-16
Approximations of the upright position from supine. The PRACTICAL CONSIDERATIONS IN
recumbent and propped-up positons are not comparable POSITIONING PATIENTS
physiologically to the upright sitting position. (Reprinted with
Prescriptive body positioning takes a significant
permission from Browse NL: The physiology and pathology
amount of the PTs time as well as other team mem
of bed rest, Springfield, 111., 1965, Charles C. Thomas.)
bers' time. Such prescriptive positioning is based on
clear indications and well-defined parameters; it is
not to be confused with 'routine' positioning. For any
hospitalized patient who is recumbent and inactive
comes: a favorable response, no response, an unfa compared with being out of hospital, body position
vorable response. With the passage of time, all three ing is a 24 hour concern, ie, a concern both during
outcomes will deteriorate. The specific time depends treatment and between treatments. Such patients are
on the multitude of factors contributing to impaired at risk of impaired oxygen transport.
oxygen transport. Despite the time and labor involved in turning a pa
Because of the significant changes that can be ex tient to prone, particularly if mechanically ventilated,
pected with positioning and positioning changes, the the benefits of this position outweigh the time and ef
physical therapist (PT) has a prime therapeutic oppor fort required to prone a p tient even for short periods.
tunity to assess and treat the patient before, during, Gi ven the considerable benefits that can be derived
and after position changes. from the prone position, a good case needs to be made
for not turning a patient prone. Frequently, therapeutic
body positioning can be effectively coordinated with
Mechanical Body Positioning
nursing interventions and other procedures.
Mechanical turning beds such as the Rotobed® have Extreme body positions and body position changes
significant benefits On oxygen transport in severely ill are the goal. However, when these are less feasible,
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18 Body Positioning 317
modified positions may be used. Even though the tient includes subjective and objective evaluation of
greatest benefits will be derived from extreme indices of the adequacy of oxygen transp0l1 (Part II).
changes as these simulate the normal range o f Among the most imp0l1ant are oxygen delivery, oxy
changes the human body is exposed to in health, gen consumption, oxygen extraction, and gas ex
small changes can be effective in altering intrapleural change indicators such as the A-a02 difference and
gradients slightly so that previously closed alveoli Pa02/PA02. Subjectively, the patient's facial expres
will be opened even though· previously opened ones sion, respiratory distress, dyspnea, anxiety, discomfort
may be prone to closure. Although modified posi and pain are assessed. Objectively, heart rate, blood
tions and small degrees of position change should not pressure, respiratory rate, Sa02, flow rates, beside
be relied upon their effects should not be minimized spirometry are readily assessed. The appropriate stan
in patients for whom extreme positions are con dardization and procedures need to be used to ensure
traindicated. Before and after every position change that the measures are both valid and reliable (see
are prime opportunities to assess the patient, and to Chapter 6). Because physiological variables are
encourage deep breathing and coughing, or suction changing from moment to moment, serial measures
the patient as indicated. over a period of time should be taken to establish an
Another important consideration is the time course average value rather than using peak or discrete mea
of change in oxygen transport with positions and po sures which may misrepresent a treatment effect.
sition changes. There are three possible outcomes: a In order to interpret and compare various mea
favorable response, no response, an unfavorable re sures, the Fi02 and any change in FI02 must be
sponse. With the passage of time, all these outcomes recorded. The use of the ratio Pa02/Fl02 enables
will deteriorate. The specific time depends on the comparison of gas exchange within and between pa
multitude of factors that contribute to the patient's tients when patients Fi02s differ or are changed
oxygen transport and the patient's responses. (Dean and Ross, 1992c). Similarly, for mechanically
ventilated patients, any changes in the ventilatory pa
rameters must also be noted, in addition to other in
MONITORING THE RESPONSE TO A BODY
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318 PART III Cardiopulmonary Physical Therapy Interventions
tion rather than the risk of diminishing returns and ations presented. Thus this chapter has presented prin
potentially worsening the patient's condition. ciples that must be considered in the decision-making
Although sicker than a noncritically ill counter process behind the prescription of therapeutic body
part, the critically ill patient has the advantage of positioning, rather than a treatment prescription for a
having more monitoring lines in place. These lines given patient.
give access to several measures and indices of oxy
gen transport, and certain hemodynamic and pul
monary variables are available continuously.
REVIEW QUESTIONS
In summary, the prescription of therapeutic body
positions is based on a detailed analysis of each pa I. Describe the effects of gravity on cardiopul
tient's unique presentation and the factors contributing monary function and oxygen transport.
to impairment of oxygen transport or threatening it. 2. Distinguish between prescriptive and routine
Then those positions that are predicted to result in the body positioning.
best therapeutic outcome are selected and applied, and 3. In reference to the seated upright position, describe
those that are predicted to lead to an adverse result are the effects of different body positions (i.e., supine,
used minimally and with appropriate monitoring. side lying, head down, and prone) on cardiopul
Monitoring is an essential component to body position monary function and oxygen transport in health.
prescription in that it confirms the prediction of benefi 4. In reference to the seated upright position, describe
cial and deleterious positions, establishes when a posi the effects of different body positions (i.e., supine,
tion change is indicated, and helps the PT anticipate side lying, head down, and prone) on cardiopul
the point of diminishing returns of any given body po monary function and oxygen transport in disease.
sitions. The specific physiological variables monitored 5. Explain how a physiologically ideal body posi
are those that reflect the steps in the oxygen transport tion with respect to oxygen transport can be dele
pathway that are most affected in a given patient. terious over time.
6. Distinguish between the prescription of therapeu
tic body positions and frequency of body posi
SUMMARY
tion changes.
The purpose of this chapter was to differentiate rou 7. Describe the principles of monitoring oxygen
tine and therapeutic body positioning designed to op transport variables during body positioning.
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18 Body Positioning 319
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England Joumal of Medicine, 304, 523-526. Pedia/rics, 94, 787-791.
Rivara , D., Artucio, H., Arcos, J., & Hiriart. C. (1984). Positional Ward, R.J., Tolas, A.G., B enveniste, R.J., Hansen, J.M., & Bonica,
hypoxemia during artificial ventilation. Cri/ical Care Medi J.J. (1966). Effect of posture on normal arterial blood gas ten
cine, 12,436-438. sions in the aged. Ceria/rics, 21, 139-143.
Ross, J., & Dean, E. (1989). Integrating physiologic principles into Weber, K.T.. Janicki, J.S., Shroff, S.G.. & Likoff, M.J. (1983). The
the comprehensive management of cardiopulmonary dysfunc cardiopulmonary unit: The body's gas exchange system. Clin
tion. Physical Therapy, 6 9, 255-259. ics in Chest Medicine, 4, 101-110.
Ross, J., & De an. E. (1992). Body po s itio n i ng. In: Zadai, c.c. West, J.B. (1985). VelJliia/ionlBlood Flow and Cas Exchange (4th
(ed.). Clinics in Physical Therapy, Pulmonary Management in ed.). Oxford: Blackwell Scientific Publications.
Physical Therapv. New York: Churchill Livingstone. West, J.B. (1995). Respira/ory Physiology-The Essel7/iols (5th
Ross, J., Denn. E., & Abboud, R.T. (1992). The effect of postural ed.). Baltimore: Williams & Wilkins.
drainage positioning on ventilation homogeneity in healthy Winslow, E.H. (1985). Cardiovascular consequences of bed rest.
subjects. Physical Therapy, 72, 794-799. Near/ Lung, 14 , 236-246.
Roussos, C.H., Fukuchi, Y., Macklem, P.T., & Engel, L.A. (1976). Zach, M.B., Ponroppidan, H., & Kazemi, H. (1974). The effect of
Influence on diaphragmatic contraction on ventilation distribution lateral positions on gas exchange in pulmonary disease. Ameri
in horizontal man. Journal of Applied Physiology, 40, 4 17-424. can Review ofRespira/ory Diseases, 110,49-53.
Copyrighted Material
Physiological Basis for Airway
Clearance Techniques
INTRODUCTION
Research studying the results of airway clearance
Techniques for assisting the mobilization of secre are often difficult to evaluate because the components
tions from the airways have long been advocated for of a given treatment have not been standardized.
use in the patient with an impairment in mucociliary Availability of equipment or education about a tech
clearance or an ineffective cough mechanism. The nique as well as cultural differences in its application
goals of this therapy are to reduce airway obstruction, confound the results. Differences in the outcome
improve mucociliary clearance and ventilation, and measures for a given technique also occur-some
optimize gas exchange. studies use wet or dry (dehydrated) sputum volume
Airway clearance techniques have been referred or radioaerosol clearance, whereas other studies use
to in the literature in a variety of ways, including pulmonary function tests, radiographic evidence or
chest p h y s i o t h e r a p y , c h esl ph y s i c a l t h e r a p y, arterial blood gases to asses the effectiveness of an
bronchial drainage, postural drainage therapy, and airway clearance technique. Although a treatment has
bronchial hygiene. been shown to be effective in one cross section of pa
321
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322 PART III Cardiopulmonary Physical Therapy Interventions
tients with pulmonary disease, care must be taken not may interfere with this process. Retained secretions
to generalize the effectiveness of the treatment across or mucus plugs in the airways may interfere with the
other groups of patients or differing time frame exchange of oxygen. The secretions need to be mobi
(acute vs. chronic). The majority of secretion clear lized from the peripheral or smaller airways to the
ance research has been focused on patients with cys larger, more central airways where they may be re
tic fibrosis, as the need for ongoing secretion removal moved by coughing or suction.
is apparent in this population. The following conditions are indications for air
Recently the "gold standard" of airway clearance, way clearance:
namely a combination of postural drainage, percus I. Cystic fibrosis-In this multisystem genetic
sion, and vibration with cough, has been challenged disease, copious (often purulent), thick secre
(Lapin, 1994). The indications for routine airway tions and mucus plugs block the peripheral and
clearance with certain diagnoses have been ques central airways. Even infants diagnosed with
tioned and the conditions leading to effective applica cystic fibrosis, whether symptomatic or not,
tion have been examined. Postural drainage and per show evidence of small airway obstruction in
cussion has been shown to be ineffective in some the form of bronchial mucus casts (Wood,
cases, and in fact, to be detrimental to the pulmonary 1989). Recurrent bacterial infections combined
status of some patients. Caregivers have also been with this mucus hypersecretion in the lungs
shown to suffer from the performance of percus leads to destruction of the bronchial walls, or
sion-repetitive motion injuries of the wrists have bronchiectasis. Airway clearance continues to
been documented as a result of regular performance be an important therapy in the treatment of
of percussion (Ford, Godreau, Burns, 1991, MMWR cystic fibrosis. This practice is supported by
Publication 1989). evidence of deteriorating lung function when
Alternate techniques have arisen out of the need to regular treatments of postural drainage and
find effective methods for those patients not respon percussion have been stopped (Desmond,
sive or not tolerant of traditional methods. A desire to 1983, Reisman, 1988).
increase compliance with airway clearance (Currie, 2. Bronchiectasis-This condition results in a
1986), especially in those patients approaching ado breakdown of the elastic tissue in the bronchial
lescence and adulthood has led to an investigation of walls, causing severe dilation. Inflamed mucosa
more independent techniques. Many of these tech and copious, purulent secretions are present in
niques have been practiced for years in European this condition. Airway clearance has been
countries, but are more recently being introduced to shown to benefit patients with bronchiectasis in
practitioners in the United States. the mobilization of sputum (Mazzocco, 1985,
It is important to remember, however, that secre Gallon, 1991).
tion clearance is but one step to take toward realizing 3. Atelectasis-This condition is caused by the
effective gas exchange in the complex oxygen trans collapse of an alveolar segment, often by re
port pathway (Dean, 1992). Airway clearance, when tained secretions. It is a documented sequela of
indicated, should be integrated into a total approach patients who have undergone surgery under
to optimize oxygen transport. general anesthesia, especially thoracic or ab
dominal surgery. Airway clearance techniques
are indicated where atelectasis is suspected to
INDICATIONS FOR AIRWAY CLEARANCE
be caused by mucus plugging (Marini, 1979,
Oxygen transport is the primary purpose of the car Hammon, 1981).
diopulmonary system (see Chapter 1). Ventilation of 4. Respiratory muscle weakness-Many patients
the alveoli is an important step in the oxygen trans with neurological or metastatic diseases or gen
port chain that allows optimal delivery of oxygen to eral debilitation, tend to hypoventilate or have an
the tissues. Several medical and surgical conditions increased work of breathing. They are unable to
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19 Physiological Basis for Airway Clearance Techniques 323
maintain adequate control of respiratory secre tance of gravity (Figure 19-1). Positioning the patient
tions and often have a weak, ineffective cough to enable gravity to assist the flow of bronchial secre
(Massery, 1987). This is especially true in pa tions from the airways has been a standard treatment
tients with diminished diaphragm innervation re for some time in patients with retained secretions
sulting from spinal cord injuries (Wetzel, 1990). (Zadai,1981).
5. Mechanical ventilation-Patients on ventilatory Knowledge of the anatomy of the tracheobronchial
support for any reason, including obtunded or tree is vital to an effective treatment. Each lobe to be
comatose patients, are at risk for atelectasis and drained must be aligned so that gravity can mobilize
are unable to independently manage their secre the secretions from the periphery to the larger, more
tions (Dickman, 1987). central airways. The mechanism of postural drainage
6. Neonatal respiratory distress syndrome-These is considered to be a direct effect of gravity on
infants are born lacking surfactant in the lungs, bronchial secretions, although a study by Lannefors
which results in atelectasis. Airway clearance (1992) observing that gravity influences regional
techniques may be useful in clearing secretions lung ventilation and volume suggested these other
and preventing atelectasis but must be moni mechanisms are also involved.
tored carefully in this population (Finer, 1978). Postural drainage (also k n o w n as b r o n c h i a l
7. Asthma-This condition is characterized by the drainage) has been shown t o b e effective i n mobiliz
presence of hyperreacti ve airways and mucus ing secretions in patients with cystic fibrosis (Wong,
plugging. Airway clearance techniques may be 1977, Lorin, 1971), bronchiectasis (Mazzacco, 1985),
beneficial to assist with the mobilization of and other pulmonary diseases (Bateman, 1981; Zaus
mucus plugs but are not helpful in treating un mer, 1968). Other treatments such as percussion, vi
complicated acute exacerbations (Eid, 1991). bration, and the active breathing cycle (ACB) tech
Chest physical therapy techniques appear not to be nique may be used while the patient is in postural
beneficial in the treatment of patients with pneumo drainage positions.
nia or chronic bronchitis without large amounts of se There are many contraindications to optimal posi
cretion production. No differences were found with tioning for PO, especially the head down or Trende
the inclusion of postural drainage and percussion in lenberg positions required for the lower lobes.
these populations (Britton, 1985; Sutton, 1982;
Rochester, 1980; Wollmer, 1985).
Percussion
Viral bronchiolitis is an asthma-like lung disease
occurring in infants less than 2 years of age. These Percussion, sometimes referred to as chest clapping,
patients do not appear to benefit from airway clear is a traditional approach to secretion mobilization. A
ance techniques (Webb, 1985). rhythmical force is applied with cupped hands to the
Also of little benefit, and possibly harmful, is the patient's thorax over the involved lung segments with
inclusion of chest physical therapy in the routine care the aim of dislodging or loosening bronchial secre
of postoperative patients without extensive secretions tions. This technique is performed with the patient in
(Eid, 1991). Even in patients with a history of lung postural drainage positions and requires a caregi ver
disease, the use of airway clearance techniques have to administer. In the United States,percussion in con
failed to affect the incidence of atelectasis as a post junction with postural drainage continues to be a
operative complication (Torrington, 1984). mainstay of treatment of the person with pulmonary
disease, especially in neonates or patients who are
unresponsive.
Postural Drainage
The proposed mechanism of action of percussion
Postural drainage (PO) is a passive technique, in is the transmission of a wave of energy through the
which the patient is placed in positions that allow the chest wall into the l u n g . T h e resulting motion
bronchopulmonary tree to be drained with the assis loosens secretions from the bronchial wall and
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324 PART III Cardiopulmonary Physical Therapy Interventions
Normal Phase: 1 2 3
FIGURE 19·1
Phases of autogenic drainage shown on a spirogram of a normal person. Phase 1: unstick phase 2:
collect, phase 3: evacuate. (VT = tidal volume,ERV expiratory reserve volume. RV reserve
= =
volume, FRC = Punctual residual capacity, IRV inspriatory reserve volume; fRV + VT + ERV
= =
vital capacity)
Vibration
moves them proximally where ciliary motion and
cough (or suction) can remove them. The combina Vibration is a sustained cocontraction of the upper
tion of postural drainage and percussion has been extremities of a caregiver to produce a vibratory force
shown to be effective in secretion removal (Denton, that is transmitted to the thorax over the involved
1962; May, 1979, Radford, 1982). A study by Ross lung segment. Vibration is applied throughout exha
man et al. (1982) is in disagreement, finding that me lation concurrently with mild compression to the
c h a n i c a l p e rcussion did n o t enhance postural chest wall. Vibration is often applied in postural
drainage in secretion removal. drainage positions following percussion to the area.
A handheld mechanical percussor may be used by A mechanical vibrator may be used by the patient or
a caregiver to decrease fatigue or by the patient for a caregiver in place of manual vibration.
self-administration of percussion. The effectiveness Vibration is proposed to enhance mucociliary
of mechanical versus manual percussion has been transport from the periphery of the lung fields to the
studied. Maxwell and Redmond (1979) found me larger airways. Since vibration is used in conjunction
chanical percussion equivalent to manual percussion with PD and percussion, many studies do not separate
in affecting removal of secretions. This is supported out the effects of vibration from the other compo
by Pryor et a1. (1979) in patients using the forced ex nents. In fact in multiple studies, the techniques of
piration technique, although there was a significant PD, percussion, and vibration are described as a single
increase in pulmonary function with manual tech entity and referred to as chest physical therapy (CPT),
niques (Pryor, Parker, and Webber, 1981). pulmonary therapy, or postural drainage therapy.
There are many contraindications to percussion. If Pavia (1976) demonstrated a higher, though not sta
the patient's pulmonary status is of greater concern tistically significant, rate of secretion clearance and
than the relative contraindications, it may be decided sputum production with vibration. However, this study
to modify and administer the treatment. was conducted with subjects in an upright position
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19 Physiological Basis for Airway Clearance Techniques 325
only, not a replication of the use of vibration clinically. applies shaking or vibration at the very beginning of
Mackenzie et al. (1980) used measurement of total exhalation to mobilize secretions. The timing of this
lung/thorax compliance to assess the effect of secre sequence is important to achieve the desired effect
tion clearance. Significant improvement in total (Webber, 1988). It has been likened to simulation of a
lung/thorax compliance was demonstrated after treat cough----deep inspiration, pause, and forceful exhala
ment with postural drainage, percussion, and vibra tion. Saline may be instilled into the airway at the be
tion in mechanically ventilated patients. Feldman et ginning of the cycle, with suctioning a component at
al. (1979) demonstrated improved ventilatory func the end of treatment of each side. Manual hyperventi
tion by showing a significant improvement in expira lation is peIt'ormed in postural drainage positions and
tory flows at lung volumes in patients receiving pos requires two competent caregivers to peIt·orm.
tural drainage, percussion, vibration, and coughing. The inspiration provided by the manual ventilation
bag, which is deeper than the patient could generate,
promotes aeration of the alveoli. The compression of
Shaking
the thorax augments the high expiratory flow rate
Shaking consists of a bouncing maneuver sometimes from the bag, accelerating the movement of the secre
referred to as "rib splinging" against the thoracic wall tions from the smaller airways to the larger bronchi
in a rhythmic fashion throughout exhalation. A concur (Clement, 1968).
rent pressure is given to the chest wall, compressing Clement (1968) reports this method of airway
the thorax. Shaking is similar in application to vibra clearance enables patients to be maintained on ventila
tion, with shaking being on one end of the spectrum in tors for long periods with normal lung function. It has
application of force, and vibration being on the oppo been demonstrated that hyperinflation and suction in
site end, supplying a gentler amount of pressure. Many the treatment of atelectasis was enhanced by the addi
variations exist throughout the spectrum between these tion of positioning and vibrations (Stiller, 1990).
techniques. Shaking may be used in place of percus
sion or intermittently with percussion and vibration.
Active Cycle of Breathing
Shaking may be used in postural drainage positions
and requires the assistance of a caregiver. Thompson (1973) in New Zealand described clearing
Shaking is proposed to work in the same manner bronchial secretions in patients with asthma by a
as vibration, mobilizing secretions to the central, technique of forced expirations and diaphragmatic
larger airways from the lung periphery. Since the breathing. British physiotherapists have modified the
compressive force to the thorax is greater, producing technique and further described it in the literature,
increased chest wall displacement, the stretch to the first as the forced expiration technique (FET) (Pryor,
respiratory muscles may produce an increased inspi 1979) and later as the ACB technique (Webber and
ratory effort and lung volume (Levenson, 1992). Pryor, 1993).
The same relative contraindications for percussion As described by Webber and Pryor (1993), the
should be observed for shaking, since it does involve ACB consists of repeated cycles of three ventilatory
application of force to the thorax. phases: breathing control, thoracic expansion exer
cises, and the FET. Breathing control is described as
gentle tidal volume breathing with relaxation of the
Manual Hyperinflation
upper chest and shoulders. The thoracic expansion
This technique is used on patients with an endotra phase consists of deep inspiration, and may be ac
cheal or tracheostomy tube that can be attached to a companied by percussion or vibration peIt'ormed by a
manual ventilation bag. One caregiver uses the bag to caregiver or the patient. This phase helps to loosen
hyperinflate the lungs with a slow, deep inspiration secretions. The forced expiration technique involves
and after a short inspiratory pause, provides a quick one or two huffs (forced expirations). Webber and
release to allow rapid exhalation. A second caregiver Pryor (1993) report huffing from a mid-lung volume
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326 PART III Cardiopulmonary Therapy Interventions
(a medium sized breath and continued down to the hV[)OSi�Cn tlOn. This sug
low-lung volume will move secretions from the pe nJY'HmcrPfl retention of
to the upper secre little sputum.
tions may be cleared a huff from lung vol
ume (a breath The ACB may be performed
Autogenic Drainage
in the sitting position, but has been shown to be more
effective in gravity assisted drainage) posi (AD) or was in
tions (Steven, 1992). troduced Chevaillier in Belgium in 1967 for treat
The period of breathing control is essential be ment of asthmatic patients. He observed that during
tween the other phases to bronchospasm sleep, as well as playing and laughing the day,
(Lapin, 1990). The o f thoracic expansion, mucus was mobilized better than PD and cJap-
which increases collateral AD is an antidyspnea technique based on
ventilation, allowing air to behind secretions and in a relaxed state without use of nMtn ,,1
pressure point," which is the basis for the FET. The airflow. It consists of three
where the pressure is to the pleural pressure. peJ]DJ1eral secretions, (2) breathing at low- to mid
The forced expiratory maneuver compres volume (tidal volume) to collect the mucus in the
sion of the airway peripherally to the EPP. A huff middle and (3) breathing at mid- to
from high lung volume causes compression within volumes to evacuate the mucus from the central air
the trachea and bronchi to move secretions from ways 1984). The patient is seated in a re
these airways. A huff continued to low lung laxed position and exhales actively with the mouth and
volume shifts the EPP more oeripherallv to move open and listens for the movement of mucus
while a wheeze. The phases in the AD tech-
a patient delJ'ict<�d in 19-1.
nhU ;AIA"" of AD's three
by pa has been ex
tients independently has been shown to clear more by Shoni (1989). The first
sputum in a shorter amount of time than PD with self- starts with an inspiration, followed by a breath hold to
combined with and shaking by ensure of lung segments by collateral fill-
a physical therapist (PT) Improvement and then a deep exhalation into the re
in pulmonary function 1986) and sputum serve volume range. By lowering mid-tidal volume
clearance (Sutton, 1983) have been demonstrated in below functional residual capacity secretions
patients with cystic fibrosis who the FET from peripheral lun!:! regions are mobilized
into their postural drainage treatments. alveolar ducts.
Because huffing has been shown to stabilize col tidal volume is lowered in the range of normal
lapsible bronchial wails, it increases the expiratory tory reserve volume. The second of AD consists
flow in patients with obstruction without air of tidal volume so that is
way (Hietpas, Another benefit of this from reserve volume into the in-
lies in its ability to maintain oxygen satura reserve volume range to mobilize secretions
tion. The decrease in oxygen saturation that has been from the of the lungs. The of the
demonstrated with postural and percussion airflow must be adjusted at each level of so
has been prevented with the use of the ACB technique that the maximal expiratory ailflow is reached without
1990). Hassani et al. (1994) has recently shown being high enough to cause collapse of the
that unproductive cough and FET resulted in the Flow volume curves show that higher flows of
movement of secretions proximally from all regions of duration can be achieved with AD (Dab. 1
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19 Physiological Basis for Airway Clearance Techniques 327
demonstrating that mucus can be moved further and at The application of PEP consists of a mask or
a faster rate. The third phase consists of deeper inspira mouthpiece connected to a one-way breathing valve
tion into the inspiratory reserve volume, with huffing to which expiratory resistors are attached. This re
often used to help in evacuating the mobilized secre sults in positive pressure in the airways during exha
tions. Control of ailflow during this final phase is es lation. A manometer in the circuit determines and
sential to avoid uncontrol led, unproductive coughing. monitors the correct pressure generated by the pa
The Belgian method has been modified by German tient. A patient uses PEP in a cycle of about 10
practioners to use a combination of diaphragmatic and breaths at tidal volume with slightly active expiration
costosternal breathing in a treatment that is not delin followed by huffing or coughing to expectorate secre
eated into phases (David, 1991). The patient varies his tions (Falk and Kelstrup, 1993).
or her mid-tidal volume in a passive exhalation followed High- or low-pressure PEP may be prescribed. In
by an active exhalation through pursed lips or through low-pressure PEP, the resistance is regulated to
the nose. The German method includes other maneuvers achieve 10 to 20 cms of water pressure during expira
in conjunction with autogenic drainage, including in tion. The pressure should be sustainable during only
halation therapy, FET, chest wall exercises, and sports. slightly active expiration. The prescription for high
Autogenic drainage has been compared with posi pressure PEP requires the patient to perform forced
tive expiratory pressure and PD with percussion/ vital capacity maneuvers through the range of expira
vibration. More sputum was produced with AD in pa tory resistances with the mask connected to a spirome
tients with hyperreactive airways (Davidson, 1988). ter. The appropriate resistor is one that produces a flow
In a 2-year crossover trial, AD was found to be as ef volume curve demonstrating a maximal forced vital
fective as conventional CPT among patients with cys capacity, good plateau, and no curvilinearity (Prasad,
tic fibrosis for improving pulmonary function 1993). In general, the range of pressure generated with
(Davidson, 1992). However, patients exhibited a high pressure PEP is 50 to 120 cms of water pressure.
strong preference for AD, increasing the likelihood of Low-pressure PEP is used more often, as it offers
compliance. Miller (1993) showed greater clearance equal effectiveness at a lower risk of pneumothorax.
of inhaled radioisotope with AD vs. the ACB tech It is theorized that PEP allows more air to enter
nique, with no significant differences in sputum through collateral channels, allowing reinflation of
weight, spirometry, or transcutaneous oxygen satura collapsed alveoli. Pressure is built up distal to an ob
tion. Giles (1993) also studied oxygen (02) saturation struction, promoting the movement of secretions to
in AD and found an increase in O2 saturation with wards the larger airways (Anderson, 1979; Groth,
AD over PD with percussion and greater sputum re 1985). Airway stability is maintained with PEP pro
covery with AD. moting improved ventilation and gas exchange, as
The learning of AD requires tactile and auditory well as airway clearance (Hardy, 1994). Supplemen
feedback and continued modifications of the patient's tal oxygen can be supplied during treatment with PEP
technique is necessary, at least initially, to achieve a and nebulized medication has been shown to be ef
good result. AD takes considerable time to learn and fectively delivered with this treatment as well (An
requires a great deal of cooperation from the patient. derson, 1982).
Therefore it is not suitable for the very young or dis PEP has been shown to benefit patients at risk for
tractable patient. postoperative atelectasis but has also gained wide
practice in the area of airway clearance, especially for
patients with cystic fibrosis (MaJhmeister, 1991). Nu
Positive Expiratory Pressure
merous studies have demonstrated PEP's effective
The development and utilization of positive expira ness. Tyrrell (1986) has shown the PEP mask to be as
tory pressure (PEP) breathing came about in the effective as conventional physiotherapy over a 1
1980s in Denmark and is now widely used in Europe month period with no difference in pulmonary func
with increasing acceptance in the United States. tion. Falk (i 984, 1993) demonstrated increased spu
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328 PART III Cardiopulmonary Physical Therapy Interventions
tum production and clearance with the use of PEP Recently approved by the FDA for use by patients
over FET alone. However. Hofmeyer (1986) found with cystic fibrosis, the Flutter'M continues to be the
FET produced a greater quantity of sputum without focus of study in the United States. Konstan et a!.
the addition of PEP. Oberwaldner (1986) evaluated (1994) compared the amount of sputum expectorated
lung function during 10 months of regular treatments with use of the Flutter'" vs. vigorous voluntary cough
with high-pressure PEP and found reduced pul vs. PD, percussion and vibration. More than three
monary hyperinflation and airway instability and times the amount of sputum was produced by subjects
higher flow rates with PEP VS. conventional CPT. with cystic fibrosis using the Flutter'" than with the
These improvements in lung function deteriorated other two methods and no adverse effects were re
only 2 months after a return to conventional CPT. A pOited. Ambrosino (1991) has reported success in the
study by Plfeger et a!. (1992) compared PEP to AD treatment of COPD patients with the device.
and found that PEP produced the highest amount of Reports in the European literature advocate the
sputum and an increase in lung function when added use of the Flutter'" for airway clearance (Althaus,
to both techniques. Finally, decreased duration of 1989). In comparison with AD, the Flutter'" was
hospitalization has been cited as a benefit of PEP for found to be equal in amount of mucus expectoration
airway clearance (Simonova, 1992). (Lindemann, 1992). When compared with the PEP
Increased independence for the patient and pre m ask, the Flutter'" showed a small increase i n
sumably, better compliance have been cited as advan spirometry, whereas the PEP-mask did not, but the
tages of this technique. However, frequent assess two techniques were otherwise comparable (Schw.
ment of patient technique and appropriate level of Med. Wschr. 1989).
resistance is recommended (Lapin, 1990). A PEP The advantages of the Flutter'" device lie in its
mouthpiece (Resistex) has recently been FDA ap pOltability and ease of learning. Young children can
proved, but the PEP mask has not yet been approved be taught to use the device effectively, and because
by the FDA. of its small size, it can easily be used for multiple
A form of PEP in combination with high fre treatments throughout the day.
quency oscillation is available in a device developed
in Switzerland. which is quickly gaining popularity in
High Frequency Chest Compression
the United States. The Flutter™ VRP1 (VarioRaw SA,
Aubonne, Switzerland) is a handheld device that in EffOits aimed at mucus clearance by creating a differ
terrupts the expiratory flow and decreases the col ential air flow rate, that is, greater expiratory than in
lapsability of the airways. The pipe-like device con spiratory flow rate, led to the development of a high
sists of a steel ball, a plastic cone, a pertorated cover, frequency chest compression (HFCC) systcm.
and a mouthpiece. The patient completes about lO to Hansen and Warwick (1990) designed a large-vol
15 deep breaths keeping the cheeks flat while the ume variable frequency air-pulse delivery system to
Flutter'M is tilted to achieve the maximum effects of be used by patients with obstructive lung disease to
the vibration in the chest. This is followed by huffing promote mucus clearance.
to eliminate the airway secretions. The ThAIRapy'" Vest (American Biosystems,
Exhalation through the Flutter'M device causes air Inc.) system consists of an inflatable fitted vest con
way vibrations and oscillating endobronchial pres nected to an air-pulse. generator by flexible tubing.
sures (Althaus, 1993) to ease the expectoration of This device provides oscillation of the entire thoracic
mucus. The PEP maintained by the Flutter™ (5 to 35 cavity at varying frequencies (5 to 25 Hz) and is used
cms of water pressure) prevents dynamic airway while sitting upright. The lung volume expired tends
compression and improves airflow acceleration. to increase with lower frequencies (less than to to 12
Therefore the improvement in expectoration is based Hz), whereas the flow rates tend to increase with
on the increase in airway diameter, as well as on the higher frequencies (12 to 20 Hz). Three frequencies
improvement in airflow acceleration (Schibler, 1992). are selected for large volume and three for high
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19 Physiological Basis for Airway Clearance Techniques 329
flows. Each frequency is used for 3 to 5 minutes with Hospitalized patients with acute exacerbation of
conti I1UOUS ul:J"osolized medication or saline to assist their lung disease have been shown to tolerate HFCC
secretion Illohilil.ation (Warwick, 1992). well (Burnett, 1993), and safety and tolerance of this
Two probahlc mechanisms of action have been of method has been demonstrated in long-term mechani
fered to explain the significant increase in sputum mo cally ventilated patients (Whitman, 1993).
bilizJlion (Kious, 1(94). The first mechanism pro Expense of the apparatus may be a significant de
poses that oscillatory airflow· leads to changes in the terrent to its use; it is more costly than other mechan
con.;islency of mucus, which result in increased spu ical aids for airway clearance. However, in a study of
tum mobilil.ation. Significant decreases in mucus vis HFCC users insured by Blue Cross and Blue Shield,
coelasticity were observed during administration of a 49% reduction in health care costs was shown in
oscillatory aitflow (Tomkicwicz et aI, (994). The sec the year following initial use of the vest as compared
ond mechanism proposes that the difference between with the year prior to HFCC use (Ohnsorg, 1994).
the expiratory and inspiratory velocities produces The impact of the llse of the HFCC device in a hospi
shear forces s lrong enough to move muclls. Chang et tal department was analyzed with a substantial sav
al. (1988) lkmonstrated that nonsymmetrical airflow ings resulting from therapy self-administration
(peak expiratory flow rates greater than inspiratory (KIous, 1993).
flow ratt:s) could be a significant factor leading to en
harlCed mllcus clearance during the administration of
Exercise
HFCC. Each chest compression produces a transient
flow pulse similar to that observed during coughing In addition to its many effects on health and well
and by using those flows with the greatest rates and being, exercise has been shown to assist in secretion
volumes, sufficient force is obtained to move mucus clearance. It has been suggested that exercise can re
in the airway (Warwick, 1991). place all or pmt of a conventional chest physiotherapy
High frequency chest wall compression has been routine in some patients or at some stages of lung dis
shown to inc re as e mucus clearance rates in dogs, ease (Zach, 1982; Andreasson, 1987; Cerny, 1989).
with the most pronounced effect in the II to 15Hz Exercise increases mucociliary transport in pa
frequency range (King, 1983). Radford et al. (1982) tients with chronic bronchitis (Oldenberg, 1979).
used bronchoscopy to demonstrate a marked increase Higher transpulmonary pressure with aerobic exer
in speed and flow of mucus by oscillations at even cise may open closed bronchi as well as increase col
higher frequencies not attainable by manual percus lateral ventilation to allow mucus to be movcd (An
sion. Results of short-term use of the ThAIRapy'" dreasson, 1987). It has also been shown that exercise
vest have been mixed, but show HFCC to be at least induced hyperventilation is more effecti ve than eu
as effective as conventional CPT. Robinson (1992) capnic hyperventilation in mobilizing bronchial se
showed no significant i m pro vement or deterioration cretions (Wolff, 1977). The contribution of expira
of lung function with its use. In two different studies, tory ailflow and exercise-induced coughing are other
Kluft (1992) and Faverio (1994) demonst rated in factors in more effective secretion removal.
creased wet and dry sputum weights using HFCC vs. Some studies conclude that exercise alone is not
manual CPT, and Arens (1993) showed similar dry sufficient and recommend its use to complement
sputum weight, but an increase in wet sputum weight other forms of airway clearance. Airway clearance
and a significant improvement in pulmonary function using PD and FET was shown to be more effective
with HFCC vs. conventional CPT. One 2-year study than exercise with a cycle ergometer at inducing spu
showed improved lung function and greater sputum tum expectoration (Sath, et ai, 1989). Results from
production in subjects with cystic fibrosis with the Bilton et al (1992) demonstrated that any modality
use of HFCC vs. manual CPT (Warwick, 1991). No which included the ACB technique in PD positions
adverse effects were ohsL rvcd with long-term use of alone or in combination with exercise is better than
the ThAIRapy'" vest. exercise alone at clearing sputum.
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330 PART III Cardiopulmonary Physical Therapy Interventions
Other studies have suggested that some forms of 1990). However, if the patient develops atelectasis,
exercise may serve as a replacement for chest physio the stress of respiratory embarrassment may also in
therapy, citing a lack of decrease in lung function fol crease intracranial pressure. In this instance, the deci
lowing the cessation of CPT and continuing with an sion may be made to tip the patient to clear the at
exercise program (Zach, 1984; Andreasson, 1987). In electasis and then subsequently return to a modified
hospitalized patients with cystic fibrosis, no signifi conservative regimen (Frownfelter, 1987).
cant change in pulmonary function was reported A fall in arterial O2 saturation has been reported
when exercise was substituted for two treatments of with the use of postural drainage from additional in
PD, percussion and vibration, and the weight of spu chest physiotherapy, although the effects of PD were
tum produced was equivalent (Cerny, 1989). not separated techniques (Selsby, 1990; Huseby,
When mucous clearance was studied, no signifi
cant differences were found between exercise on a
cycle ergometer, postural drainage, and PEP mask
breathing (Lannefors, 1992). Increases in sputum ex Contraindications for Postural Drainage
pectoration on exercise vs. nonexercise days have
All Positions Are Contraindicated
been reported (Zach, 1981; Baldwin, 1994). For pa for the Following:
tients with cystic fibrosis who demonstrate compli
Intracranial pressure (ICP) > 20 mm Hg
ance with an exercise program alone or in addition to
Head and neck injury until stabilized
another form of secretion mobilization, there is evi
dence of positive prognostic value (Nixon, 1992). Active hemorrhage with hemodynamic instability
It is difficult to compare these studies across the Recent spinal surgery (e.g .• laminectomy) or acute
board; however, because the mode and length of ex spinal injury
It is essential that the therapist and the health care Distended abdomen
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19 Physiological Basis ror Airway Clearance Techniques 331
[976). Therefore O2 saturation levels should be mon show an intolerance for percussion as part of chest
itored during treatment, most importantly in those pa physiotherapy. Campbell et a1. (1975) demonstrated
tients with known [ow Pa02 values. a fall in FEV I associated with percussion that was
Caution must also be used in treating the patient not evident when percussion was omitted. Adminis
with end-stage lung disease in postural drainage posi tration of a bronchodilator before treatment with per
tions because of the risk of hemoptysis (Hammon, cussion abolished the fall in FEV I. Wheezing has
1979; Stern, [978). also been associated with percussion and vibration in
Decreased cardiac output (Laws, 1969; Barrell, patients with cystic fibrosis and COPD (Tecklin,
[978) has been associated with chest physiother 1975; Feldman, 1979).
apy treatment; however, the effects of postural The box below summarizes the precautions and
drainage were not separated from those of percus contraindications for external manipulation of the
sion and vibration. thorax associated with percussion, shaking, and high
In the pediatric population, some experts recom frequency chest compression. Vibration involves less
mend caution with the position used to treat the ante force to the thorax and may be better tolerated than
rior lower lobes because of the risk of gastroe the aforementioned techniques. A nebulized bron
sophageal reflux. The box on p. 330 summarizes the chodilator may be administered during a treatment of
precautions and contraindications for postural high frequency chest compression to avoid the conse
drainage. quences of hyperreactive airways.
in Pa02 in acutely ill patients (Connors, 1980), espe Recently placed pacemaker
cially in patients with cardiovascular instability (Oor Suspected pulmonary tuberculosis
menzano, 1972) and in neonates (Fox, 1978). The
Lung contusion
factor that seems most associated with or predictive
Bronchospasm
of the effect is the baseline or before-therapy Pa02
Osteomyelitis of the ribs
(McDonneJl, 1986).
Cardiac arrhythmias have been associated with Osteoporosis
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332 PART III Cardiopulmonary Physical Therapy Interventions
creased risk of pneumothorax (Oberwaldner, 1986). Ease (of learning and of teaching)
Bronchodilator premedication should be considered Skill of therapists/teachers
when applying PEP in patients who show clinical
Fatigue or work required
and/or physiological signs of airway hyperreactivity
Need for assisLants or equipmelll
(Pfleger, 1992).
LimiLations of technique based on disease type and
The increased aitilow produced by the huff cough,
severity
as in the ACB technique, may aggravate bron
Costs (direct and indirect)
chospasm (Hietpas, 1979). Additionally, Hietpas cau
tions that spontaneous explosive coughing may be Desirability of combining methods
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19 Physiological Basis for Airway Clearance Techniques 333
suitable for this age group, depending on the child's Accessibility of equipment or trained personnel
attention span and cooperation. Children 12 years of limits the use of some airway clearance techniques.
age and older are capable of using any of the airway Many of these techniques are new or not available to
clearance techniques, including AD, which requires many health care centers, especially in the United
more concentration than a younger child is typically States, since they were pioneered in Europe. Proper
able to exhibit. instruction and review of a patient's technique is im
The lack of an assistant to provide airway clearance perative to achieve optimal results, and in the case of
is a factor that prompts many patients to seek methods PEP, the reassessment of resistance is recommended.
other than postural drainage and percussion. HFCC, In the case of AD, the method is limited by the num
PEP, Flutter''", ACB, exercise and AD are techniques ber of instructors available to teach the technique to
that provide independence from a caregiver. These patients and requires a great deal of time on the part
methods have been chosen by adults living on their of the health care team member to learn. The patient
own, students away at school, and adolescents eager must possess motivation and the time to learn the
for independence. For optimal results, each tech technique and be willing to "fine tune" the technique
nique's effectiveness must be regularly reevaluated by with the therapist periodically.
a health care team member skilled in the area of air In this area of cost containment, the financial re
way clearance after it has been agreed that a patient ex quirements of a technique must also be taken into con
hibits independence in a given technique. sideration, especially in the case of a chronic condi
The clinical status of the patient during each hos tion. The availability of any given method then, could
pital admission must be evaluated to determine the be determined by the insurance coverage or additional
appropriateness of an ACT. For example, airway hy financial resources of the patient. If several methods
perreactivity might be worsened by PO and percus prove to be equally effective, it would be prudent to
sion, and care must also be taken when using ACB in select the methods requiring the least expense. Al
this case. HFCC, Flutter''", and exercise should be though the most common form of airway clearance in
preceded with an inhaled bronchodilator in this case, the United States continues to be postural drainage
and PEP can be performed concurrently with bron and percussion by a caregiver, this often proves to be
chodilator administration. AD lends itself well to use quite expensive, especially if a family member is not
by patients with airway hyperreactivity. available for ongoing home treatments. The equip
Gastroesophageal reflux prohibits patients from ment needed for ACTs varies. The generator required
performing airway clearance in conventional PO po for HFCC is expensive to purchase or rent on a
sitions. In this instance, AD, Flutter''', PEP, HFCC, monthly basis. Mechanical percussors or vibrators are
and exercise, or ACB in upright positions, are the moderately priced, and PEP and the Flutter™ valve are
preferred treatments. In infants or neurologically im the least expensive of those techniques requiring
paired patients where PO and percussion is the treat equipment. A patient independently using ACB or AD
ment of choice, modified PO positions are used and consumes the least financial resources.
sufficient time allowed between a feeding and a treat Ultimately, the regular use of a particular ACT by
ment with PD. a patient is governed by personal belief in the effec
The severity of a patient's lung disease will affect tiveness of the method for his or her own disease
the choice of ACT. Specifically, a patient with end process, the manner in which the method affects the
stage lung disease or an acute exacerbation might not patient family's life habits, and the patient's willing
have the required energy level to carry out an active ness to use the technique on a daily basis. Compli
airway clearance technique such as AD or PEP effec ance is ultimately the best measure of any airway
tively. A more passive technique would be appropri c1earancc technique's effectiveness.
ate, at least temporarily. Also a marked decrease in Clinical outcome measures to assess the effective
PFT's limits the airflow control necessary for AD, ness of an airway clearance technique can be fol
F1utter™, or PEP. lowed during clinical appointments or periods of hos
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334 PART III Cardiopulmonary Physical Therapy Interventions
pitalization. Radiographic changes, arterial blood gas must consider many factors in recommending an
values, O2 saturation, and pulmonary function tests alternate form of airway clearance. Age of the pa
may demonstrate adequate airway clearance or the tient is a prime factor in the appropriateness of a
need to reassess the appropriateness of the technique selected technique. For infants, PO, percussion,
or the application of it by the patient. Though it is and vibration remain the mainstay of secretion
difficult to quantify, many patients subjectively rely clearance. In older children, the active cycle of
on amount of sputum production to guide their choice breathing may be initiated, positive expiratory
of secretion clearance method. This measure provides pressure and Flutter'" may be taught, and high fre
immediate feedback to the patient without visiting the quency chest compression is available for children
hospital or clinic. after about age 3 or 4. Exercise should be included
in treatment as well. Children 12 years of age or
older and adults have the complete range of airway
SUMIVIARY
clearance techniques at their disposal, including
The goals of airway clearance are to decrease airway autogenic drainage.
obstruction, improve secretion clearance, and im Treatments aimed at secretion clearance require an
prove ventilation and gas exchange. Routine applica individualized approach to tailor the treatment to the
tion of airway clearance techniques in many condi patient's condition and lifestyle, to continuously
tions has not been shown to be effective in achieving reevaluate the patient's status, and to monitor the re
these goals. ACTs are not without side effects or sponse to treatment.
complications; routine use of these methods is not Acceptance of the specific treatment technique by
recommended without clear indications. the patient and family is paramount; compliance is
Indications for ACTs have been divided into the key to achieving effective treatment, especialJy in
those for acute illness and chronic disease states. chronic lung disease.
In acute illness, traditional chest physical therapy, Further research in the area of airway clearance
that is, PO, percussion, and vibration, has been is certainly needed. Studies with consistent applica
shown to be beneficial in patients with copious se tion of techniques, similar outcome measures, and
cretions and in the treatment of atelectasis (Kir consistent study design will assist practitioners in
iloff, 1985). For patients with cystic fibrosis, treat evaluating and recommending a given technique of
ment with PEP and exercise in conjunction with airway clearance.
PO, percussion, and vibration were also shown to
be effective in an acute exacerbation (Boyd, 1994).
REVIEW QUESTIONS
Acute asthma, bronchitis, and pneumonia without
copious secretions, bronchiolitis, and routine post I. What kinds of pulmonary conditions would not
operative conditions were not shown to benefit be likely to benefit from ACTs?
from PO, percussion, and vibration (Sutton, 1982; 2. Which ACTs would be the easiest (for the thera
Eid,1991). pist and the patient) to incorporate into a routine
In chronic disease states, patients with cystic fi of conventional PO and percussion?
brosis and bronchiectasis were found to benefit from 3. What possible factors could be considered a con
PO, percussion, and vibration (Kiriloff, 1985). Posi traindication to chest percussion with PO in a
tive expiratory pressure and exercise were also shown trauma or postoperative patient?
to be effective in the chronic management of patients 4. What factors might make it difficult for a patient
with cystic fibrosis (Boyd, 1994). to accept a new method of airway clearance?
In those patients for whom traditional chest 5. Which ACTs would be most appropriate during
physical therapy is not effective, the caregiver an acute exacerbation of a pulmonary disease?
Copyrighted Material
19 Physiological Basis for Airway Clearance Techniques 335
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stracted in Pediatric Pulmonol, suppl. 9, 240. removal of mucus in patients with cystic fibrosis. A me rican Re
MMWR Publication From the Centers For Disease Control (CDC). view of Respiratory Diseases, 126, 131-135.
(1989). Occupational diseas surveillance: Carpal tunnel syn Salh, W., el al. (1989). Effect of exercise and physiotherapy in aid
drome. .lAMA, 282 (7), 886- 89. ing sputum expectoration in adults with cystic fibrosis. rhomx,
Muszynski-Kwan, A.T., Perlman, R., Rivington-Law, B.A. (1988). 44, 1006-1008.
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cystic fibrosis: A review. Phys iology of Canada, 40 (1),28-32. tory breathing as chest physiotherapy pelformed by the Fluttel'
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327,1785-1788. Selsby, D., lones, 1.G. (1990). Some physiological and clinical as
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tions against a variable resistance: A new chest physiotherapy 64,621-631.
method in cystic fibrosis. Pediatric Pulmonology, 2, 358-367. Shoni, M.H. (1989). Autogenic drainage: A modern approach to
Ohnsorg, F. (1994). A cost analysis of high-frequency chest wall physiotherapy in cystic fibrosis. Journal Royal Soc Medicine,
oscillation in cystic fibrosis. Abstract presented at the suppl. 16,82,32-37.
ALA/ATS International Conference, Boston. Shultz, K. (1980). Compliance with therapeutic regimens in pedi
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American. Review of Respira/ory ojDiseases, 120,739-745. Simonova, 0., et al. (1992). PEP-mask therapy in complex treat
Orenstein, D.M., et al. (1985). Ex rcis conditioning in children ment of cystic fibrosis patients. Abstracted in Pediatric Pul
with asthma. Journal of Pediatrics, 106, 556-560. }1lonology, suppl. 8,245.
Passero, M.A., Remor, B., Salomun, 1. (1981). Patient-reported com Stern, R.e., et al. (1978). Treatment and prognosis of massive he
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265-268. Diseases, I 17, 825-829.
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Sleven, M.H., el al. (1992). Physiolherapy versus cough alone in Webber. B.A, (1988). Physiotherapy patients receIving me
Ihe treatment of cystic fibrosis. New Zealand JOt/mal P hysio chanical ventilation, In Webber, B,A, (Ed,) The Brompton
therapy, 20 (2), 31 Hospital Guide to Chest Physiotherapy (Fifth Oxford,
StiJler, K, et al. (1990), Acute atelectasis: A comparison of Blackwell Scientific Publications.
two chest physiotherapy regimens, Chest, 98, 1336-1340. Webber, B., Pryor, J, (1993). Active .:yclc of breathing techniques,
SUHon, P.P" et aL (1982), Chest Physiotherapy: A review. Euro In Bronchial Hypersecretion: Current Chest Physiolherapy in
pean Journal of RespirQlOfY Diseases, 63, 188-201. Cystic Fibrosis (CF), Published by International Physiotherapy
Sutton. P.P., aL (1983). Assessment o f the forced expiration COl11minee for Cystic (lPC/CP).
technique, postural drainage and directed coughing in chest Webber, BA, Pryor, J. A. (1993). Physiotherapy skills: techniques
physiotherapy. Euro pealJ Joumal oj Respiratory- Disea ses, 64, and adjuncts, In Physiotherapy for Respiratory and Cardiac
Problems, Edinburgh: Churchill Livingstone,
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in patients cystic fibrosis. Physical Therapy, 55, 108H084. with spinal cord injury. In Irwin. S, Tecklin, 1.S. (Eds.), Car
Thompson, BJ. (1973), The physiotherapist's role in the rehabilitation diopulmonary Physical Therapy (Second Edition), Sl. Louis:
of the asthmatic. New Zealalld Journ£li ojPhysiothf!rapy, 4, 11-16. CV Mosby Co,
Tomkiewicz, K, Bivij, A" King, M. (1994), Rheologic studies re Whitman, J" cl al. (1993). Preliminary evaluation of high-fre
garding high frequency chest compression (HFCC) and im quency chest compressIon for secretion clearance in mechani
provements of mucus clearance in cystic fibrosis, Abstract pre cally ventllated patients. Respiratory Core, 38 (10), 1081-IOS7,
sented at ATS International Conference, Boston. Wolff, R.K, et al. (1977), Effects of exercise and eucapnic hyper
Torrington, K, Sorenson, D" Sherwood, L (1984), Postoperative ventilation on bronchial clearance in man. Jo u rna l of Applied
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lowing gastric stapling, Che st, 86, 891-895. 50.
Tyrrell, J.C, Hill, EJ, Martin, 1. (1986), Face mask physiotherapy Wollmer, p" et aL (1985). Inefficiency of chest percussion in the
in cystic fibrosis. Archives of Di sea ses of file Childhood. 61, physical therapy of chronic bronchitis, European Joum al of
598-61 L R espiralOl)' Disease, 66, 233-239,
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compression. Symposium presented at Sixth Annual North first two years, Pediatric Puhnonol, 4,
American Cystic Fibrosis Conference, Washington, D,C Zach. M., Oberwaldner, B.. Hausler, p, (1982). Cystic fibrosis:
Webb, M,S,C.. et (1985), Chest physiotherapy in acute bronchi physical exercise versus chest phy,iotherapy. Archives of Dis·
olitis, Archives of the Childhood, 60,1078-1079, eases of the Child/lOUd. 57, 587-589.
Webber, B.A., et al. (l986). Effect of postural drainage, incorpo Zadai, Cc. (1981). Physical therapy for the acutely i II medical pa
rating tbe FET, on pulmonary function in fibrosis. 61 (12), J746-1753.
tient. Physical The rapy ,
British Journa/ oIDiseases of the Chest, 80, 353-359. Zausmer, E. (1968), Bronchial drajnage: Evidence supporting tbe
Webber, B.A, (1988). Is postural drainage necessary? Papa Pre procedures. Ph ysica l Therapv, 48, 586·591
sented at Tenth International Cystic Fibrosis Conference, Sydney,
Copyrighted Material
Clinical Application of Airway
Clearance Techniques
INTRODUCTION
The previous chapter addressed the physiological
Oxygen transport from the lungs to body tissues can basis of each technique, the history of its use, and re
be limited in patients that possess an ineffective search to establish its effectiveness. This chapter pro
cough or an impairment of normal mechanisms of vides an introduction to the application of these tech
mucociliary clearance. The caregiver must augment niques to patients and addresses the benefits and
these mechanisms using the array of techniques avail liabilities of each technique.
able for airway clearance. Each technique has a phys Airway clearance techniques differ with respect to
iological basis for improving the mobilization of equipment needs, the skill level required to perform
secretions. The caregiver must consider the patho them, and their usefulness with various clinical prob
physiology and the symptoms of the disease, the lems. Matching a patient with an appropriate method
availability of the technique to the patient, and the or combination of methods may increase effective
patient's acceptance of the technique in prescribing ness, reduce complications, and promote adherence
an optimal method of airway clearance. to the long-term treatment.
339
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340 PART III Cardiopulmonary Physic.al Therapy Interventions
1
----
KPS. ,;,1>(1,.,
FIGURE 20-1
Upper lobes.
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20 Clinical Application of Airway Clearance Techniques 341
FIGURE 20-2
Upper, middle, and lower lobes.
FIGURE 20-3
Lower lobes.
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342 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 20-4
A, right upper lobe-posterior segment (anterior view-patient positioned three-fourths prone).
B, right upper lobe-posterior segment (posterior view). NOTE: Upper extremities toward prone,
underneath arm pulled free from under patient's body. This position may also be a modified
position for right lower lobe posterior segment.
FIGURE 20-5
Both lower Jobes-posterior segments (shown using teJeJphone books or piJlows for home use). A
beanbag chair is also helpful for home treatments.
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20 Clinical Application of Airway Clearance Techniques 343
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344 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 20-6
A and B, If children are able to role play the treatment, they will better understand what is expected
and be more cooperative with therapy.
the pediatric population, who will require consider breathing. Percussion is used in postural drainage po
able distractions to maintain a desired position. sitions for increased effectiveness (Sutton, 1985;
The cost of the equipment required for PD is mini Bateman, 1979) and may also be used dUling the ac
mal; inexpensive items may be used for home treat tive cycle of breathing (ACB) technique.
ment. However, the cost of a caregiver's time to pro
vide the treatment, especially in the case of a chronic
Equipment Required for Percussion
disease, may be substantial. A family member may
be willing to learn the procedure, which would pro 1. The only equipment required for manual per
vide a benefit in terms of expense, as well as flexibil cussion is the caregiver's cupped hands to de
ity in scheduling (Figure 20-6). liver the force to mobilize secretions.
2. For the adult and older pediatric population,
electric or pneumatic percussors that mechani
PERCUSSION
cally simulate percussion are available. This
Percussion is performed with the aim of loosening re enables a patient to apply self-percussion more
tained secretions from the airways so they may be re effectively. Several models have variable fre
moved by suctioning or expectoration. A rhythmical quencies of percussion, as well as different lev
force is provided by clapping the caregiver's cupped els of intensity.
hands against the thorax over the affected lung seg 3. Several devices may be used to provide percus
ment, trapping air between the patient's thorax and sion to infants: padded rubber nipples, pediatric
the caregiver's hands (Figure 20-7). It is performed anaesthesia masks, padded medicine cups, or
during both the inspiratory and expiratory phases of the bell end of a stethoscope.
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20 Clinical Application of Airway Clearance Techniques 345
FIGURE 20-7
Chest percussion.
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346 PART III Cardiopulmonary Physical Therapy Interventions
the scapula, and the clavicle should all be The expense of a mechanical device for percus
avoided. Percussion over t h e floating ribs sion is minimal compared with the ongoing cost of a
should also be avoided, since these ribs have caregiver to provide percussion and PD in the hospi
only a single attachment. tal setting or a home care situation. In the case of
7. Percussion should not be performed over breast young children or unresponsive patients, there are
tissue. This would produce discomfort and di few choices for airway clearance. For other popula
minish the effectiveness of the treatment. In the tions, however, a more independent method would
case of very large breasts, it may be necessary also prove to be more cost-effective if adequate com
to move the breast out" of the way with one pliance was achieved.
hand and percuss with the other hand.
8. A patient may be taught to perform one-handed
VIBRAnON/SHAKING
self-percussion to those areas that can b e
reached comfortably, either manually o r with a The techniques of vibration and shaking are on oppo
mechanical percussor. This does however, vir site ends of a spectrum. Vibration involves a gentle,
tually preclude the treatment of the posterior high frequency force, whereas shaking is more vigor
lung segments. ous in nature. Vibration and shaking are performed
with the aim of moving secretions from the lung pe
riphery to the larger airways where they may be suc
Advantages and Disadvantages of Percussion
tioned or expectorated. Vibration is performed by co
The addition of percussion to a PD treatment may en contracting all the muscles in the caregiver's upper
hance secretion clearance and shorten the treatment. extremities to cause a vibration while applying pres
Patients often find the rhythm soothing and are re sure to the chest wall with the hands. Shaking is a
laxed and sedated by percussion, especially young stronger bouncing maneuver, which also supplies a
children and infants. concurrent, compressive force to the chest wall.
Patients with chronic lung disease, who have used Like percussion, vibration and shaking are lIsed in
PD and percussion for many years and have found it conjunction with PD positioning. Unlike percussion,
effective, are reluctant to try an alternative method of they are performed only during the expiratory phase
airway clearance. Compliance with this method is de of breathing, starting with peak inspiration and con
pendent on the availability of a family member or tinuing until the end of expiration. The compressive
other caregiver to provide the treatment. Mechanical forces follow the movement of the chest wall.
percussors allow the patients more independence or
decrease fatigue of a caregiver, and are especially use
Equipment Required for Vibration/Shaking
ful in patients requiring ongoing treatment at home.
Percussion is not well-tolerated by many patients I. For manual techniques, the only equipment re
postoperatively without adequate pain control. The quired is the caregiver's hands.
force of percussion is also a threat to patients with os 2. Mechanical vibrators are available to administer
teoporosis or coagulopathy. Other contraindications the treatment and are useful for self-treatment
are listed in Chapter 21. Percussion has been associ by a patient or to reduce fatigue in the caregiver.
ated with a fall in oxygen saturation, which can be 3. For infants, a padded electric toothbrush is an
eliminated with concurrent thoracic expansion exer alternative (Crane, 1990).
cises and pauses for breathing control (Pryor, 1990).
Delivering percussion for extended periods on an
Preparation for Vibration/Shaking
ongoing basis can result in injury to the caregiver,
whether a family member or a health care provider. I. Place the patient in the appropriate PD posi
Repetitive motion injuries of the upper extremities tion or modified position as the patient's sta
may occur in long-term delivery of percussion for tus allows.
airway clearance. 2. Place a thin towel or hospital gown over the
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20 Clinical Application of Airway Clearance Techniques 347
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348 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 20-10
Simulated cough using self-inflating bag and chest compression with vibration.
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20 Clinical Application of Airway Clearance Techniques 349
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350 PART III Cardiopulmonary Physical Therapy Interventions
ACB Technique
• Breathing control
• Breathing control
• Breathing control
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20 Clinical Application of Airway Clearance Techniques 351
• Mouth half or almost closed • Mouth open, O-shaped to keep glottis open
• Abdominal muscles not used From mid to low lung volume moves periph
eral secretions
• Sound more like hissing or blowing
from high to mid lung volume moves proxi
• Mouth shaped ;)s for "E" sound mal secretions
• Incorrect quality of expiration • Muscles of the chest wall and abdomen contract.
• Too vigorous or long. producing paroxysmal • Sound is like a sigh. but forced.
coughing
• Rate of expiratory flow varies with the following:
Too gentle
The individual
•
• "Catching" or "grunting" at the back of the throat The degree of airflow obsu'lIction
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352 PART III Cardiopulmonary Physical Therapy Interventions
Advantages and Disadvantages of ACB Technique quired for the patient in whom percussion or shaking
during the thoracic expansion phase increases the ef
Incorporation of the ACB technique into a treatment fectiveness of the treatment.
of PO and percussion allows the patient to participate Care must be taken to adapt the ACB technique for
actively in a secretion mobilization treatment and of patients with hyperreactive airways or after surgery.
fers the prospect of independently managing airway This individual approach will be helpful with all pa
clearance. The ACB may be introduced at 3 or 4 tients using the technique to optimize effectiveness.
years of age, with a child becoming independent in
the technique at 8 to 10 years of age.
AUTOGENIC DRAINAGE
The technique may be adapted for patients with
gastroesophageal reflux, bronchospasm, and an acute Autogenic drainage (AD) is a breathing technique
exacerbation of their pulmonary disease. A decrease that uses expiratory airflow to mobilize bronchial se
in oxygen saturation caused by chest percussion may cretions. It is a self-drainage method that is per
be avoided by using the ACB technique (Pryor, formed independently by the patient in the sitting po
[990). When the technique is performed indepen s i t i o n . AD c o n s i s t s of three phases: (1) the
dently, the cost of using ACB technique for the long "unsticking" phase. which loosens secretions in the
term is minimal. peripheral airways, (2) the "collecting" phase, which
However, in young children and in extremely ill moves the secretions to the larger, more central air
adults, a caregiver wi/I be necessary to assist the pa ways, and (3) the "evacuating" phase, which results
tient with this technique. An assistant will also be re- in the removal of the secretions. This technique of
airway clearance requires much patience and concen
tration to learn and is therefore not suitable for young
children. It is ideal, however, for the adolescent or
adult who prefers an independent method.
FIGURE 20-12
Autogenic drainage: German method. Autogenic drainage Preparation for AD
shown on a spirogram of a normal person. The method is
I. The patient should be seated upright in a chair
not divided into separate phases. (Vt=tidal volume,
with a back for support. The surroundings should
ERV=expiratory reserve volume, RV=reserve volume,
be devoid of distractions, allowing the patient to
FRC=functional residual capacity, IRV=inspiratory reserve
volume, IRV + Vt + ERV = vital capacity). (From David, concentrate on the breathing technique.
A. (1991). Autogenic drainage-the German approach. In 2. The upper airways (nose and throat) should be
Pryor, J. (Ed.), Re pir{/{orv Care, Edinburgh: Churchill cleared of secretions by huffing or blowing
Livingstone.) the nose.
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20 Clinical Application of Airway Clearance Techniques 353
3. The caregiver should be seated to the side and 5. The evacuating phase-In this phase, the pa
slightly behind the patient, close enough to hear tient increases inspiration into the inspiratory
the patient's breathing. One hand should be reserve volume range. This middle-to-high
placed to feel the work of the abdominal mus lung volume breathing continues until the se
cles and the other hand placed on the upper cretions are in the trachea and are ready to be
chest (see Figure 20-12). expectorated. The collected mucus can be
evacuated by a stronger expiration or a high
volume huff. Nonproductive coughing should
Treatment With Autogenic Drainage
be avoided, since it may result in collapse of
l. In all phases, inhalation should be done slowly, airways.
though the n o s e if possible, using the di 6. Compression of the airways should be avoided.
aphragm or lower chest. A 2- to 3-second If wheezing is heard, the expiratory t10w rate
breath hold should follow, allowing collateral must be decreased. Beginners may have to use
ventilation to get air behind the secretions. p u rs e d l i ps to a v o i d a i r w a y c o m p r e s s i o n
2. Exhalation should occur through the mouth (Chevaillier, 1992). Instructing the patient t o
with the glottis open, causing the secretions to roll the tongue (if possible) may assist i n con
be heard. The vibrations of the mucus may also trolling the expiratory flow rate.
be felt with the hand placed on the upper chest. 7. A German modification of AD resulted from
The frequency of these vibrations reveals their the observation that many patients had diffi
location. High frequencies mean that the secre culty breathing in the expiratory reserve vol
tions are located in the small airways; low fre ume range. In the simplified procedure, the pa
quencies mean that the secretions have moved tient begins by varying the mid-tidal volume
to the large airways (Chevaillier, 1992). without excessive effort. After a passive but
3. The umticking phase-This phase mobilizes rapid expiration, an actively performed expira
mucus from the periphery of the lungs by lower tion follows, achieving exhalation to a low ex
ing the mid-tidal volume below the functional piratory reserve volume (David, 199 1). See
residual capacity level (Schoni, 1989). In prac Figure 9- 1, p. 155. for the difference between
tice, inspiration is followed by a deep expiration the two methods of AD.
into the expiratory reserve volume. The patient 8. The duration of each phase of AD depends on
attempts to exhale as far into the expiratory re the location of the secretions. The duration of
serve volume as possible, contracting the abdomi a session depends on the amount and viscos
nal muscles to achieve this. This low lung volume ity of the secretions. A patient who is experi
breathing continues until the mucus is loosened enced in autogenic drainage will clear secre
and starts to move into the larger airways. t i o n s in a s h o r t e r a m o u n t of t i m e t h a n a
4. The collecting phase: This phase collects the beginner. An average treatment wiiJ be 30 to
mucus in the middle airways by increasing the 45 minutes in length.
lung volume over the unsticking phase. Tidal
volume breathing is then changed gradually
Advantages and Disadvantages of AD
from expiratory reserve volume toward the in
spiratory reserve volume range (Schoni, 1989) After instruction in the technique of AD has been
so that the lungs are expanded more with each completed, it may be performed independently by pa
inspiration. The patient increases both inspira tients over 12 years of age and requires no additional
tion and expiration to move a greater volume of equipment. Since it does not require the use of pos
air. This low to middle lung volume breathing tural drainage positions, it is appropriate for patients
continues until the sound of the mucus de with gastroesophageal ret1ux. It is also recommended
creases, signaling its movement into the central f o r use in patients with airway hyperreactivity
airways to be evacuated. (Pfleger, 1992).
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354 PART III Cardiopulmonary Physical Therapy Interventions
Although it is widely used in Europe, the use of PEP is performed in the upright position and can
AD in the United States is limited by the lack of be used during acute episodes, as well as chronic pul
trained caregivers but is growing in popularity. monary conditions. Children over 4 years of age may
To learn this technique, patients must demonstrate be instructed in the technique, and PEP may provide
good self-discipline and possess the ability to concen an independent method of airway clearance in older
trate. This method takes more practice than others. A children and adults.
patient must also be available for periodic reevalua
tion and refinement of the technique.
Equipment Required For Positive
AD is not the treatment of choice for a patient who
Expiratory Pressure
is unmotivated or uncooperative, and the study of
flow volume curves suggests that AD would not be I. A PEP mask is manufactured by Astra Tech in
appropriate for small children even if they are coop Denmark, but is not approved by the Federal
erative (Dab, 1979). Department of Agriculture (FDA) and is not
The period of hospitalization for an acute pul available in the United States. However, a self
monary exacerbation is a difficult time for a patient made PEP mask system may be assembled
to learn AD. In fact, patients who are skilled in the using a soft ventilation mask, a T-piece, a one
technique choose a more passive (less energy-con way valve, and resistors of various sizes or an
suming) form of airway clearance at such a time until adjustable resistor valve (Figure 20-13). The
they return to their baseline pulmonary status. mask should fit tightly but comfortably over the
mouth and nose.
2. Another form of PEP delivery consists of a
POSITIVE EXPIRATORY PRESSURE
mou thpiece attached to a one way valve (for
Positive expiratory pressure (PEP) creates a back use with noseclips) with adjustable expiratory
pressure to stent the airways open during exhalation resistance. The Resistex ™ valve (from Mercury
and promotes collateral ventilation, allowing pressure Medical, Clearwater, Fla.) has recently been
to build up distal to the obstruction. This method of FDA-approved.
airway clearance prevents collapse of the airways, 3. A manometer is placed proximal to the resistor
which eases the mobilization of secretions from the in the initial stages of instruction in the use of
periphery toward the central airways. A mask or PEP. First, the manometer helps to determine
mouthpiece apparatus provides a controlled resis and monitor the appropriate level of resistance
tance (10 to 20 cm water pressure) to exhalation and needed for the patient to achieve 10 to 20 cm of
requires a slightly active expiration; tidal volume in water pressure throughout exhalation. Sec
spiration is unimpeded. ondly, the visual display of the manometer
A variation of positive expiratory pressure, known serves as feedback to assist the patient in mas
as high-pressure PEP, uses the same mask apparatus tering the technique (Mahlmeister, 1991).
but at much higher levels of pressure (50 to 120 cm 4. Aerosol medication by nebulizer or metered
water pressure). Inspiration is performed to total lung dose inhaler may be placed inline to be deliv
capacity; this is followed by a forced expiratory ma ered simultaneously with PEP for airway clear
neuver against the PEP mask. ance. Deposition .of medication improves with
A form of intermittent PEP is provided by a de PEP (Andersen, 1982; Frischnecht-Christensen,
vice called the FlutterT". This pipe like device pro 1991).
vides (I) positive expiratory pressure, (2) oscillation 5. Supplemental oxygen may also be placed inline
of the airways (at frequencies of 6 to 20 Hz) and for patients who are hypoxic.
(3) accelerated expiratory flow rates to loosen secre 6. With high-pressure PEP mask therapy, spirom
tions and move them centrally. etry is used to determine the appropriate resis
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20 Clinical Application of Airway Clearance Techniques 355
FIGURE 20-13
Self-made PEP mask system.
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356 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 20-15
Use of Flutrer (R) valve.
FIGURE 20-14
Treatment With PEP
Preparation for PEP therapy.
1. The patient should be instructed to breathe into
ratory rate, whereas too small of a resistor will the mask or mouthpiece to tidal volume using
create too high a pressure or a slow respiratory the lower chest and abdomen. Exhalation into
rate (McIlwaine, 1993). the mask or mouthpiece should be slightly ac
4. For high-pressure PEP, appropriate resistance is tive but not forced.
determined by connecting the outlet of the PEP 2. The patient continues breathing into the mask
mask to a spirometer. Forced vital capacity ma or mouthpiece for 10 to 15 breaths, using a nor
neuvers are peliormed through different expira mal respiratory rate. Initially, the patient and
tory resistors. The resistor producing the highest caregiver monitor the effort by means of the
forced vital capacity through the PEP mask is manometer, ensuri'ng that a pressure of 10 to 20
selected for continued use (Oberwaldner, 1986). cms of water pressure is achieved throughout
5. To use the Flutter'" valve, the patient should be exhalation. After the technique is mastered with
seated upright (Figure 20-15). The full effects the appropriate resistor, the manometer may be
of the vibration induced by the Flutter™ may be removed from the system. The appropriate re
received by changing the angle of the device. sistance should be rechecked periodically dur
Movement of the Flutter'M upward increases the ing clinical visits or periods of hospitalization.
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20 Clinical Application of Airway Clearance Techniques 357
3. After a series of 10 to 15 breaths, the mask is PEP therapy does not possess some of the limitations
removed from the face and the patient performs of conventional PD and percussion for secretion clear
a series of huffs (and coughing if necessary) to ance and is therefore applicable to a wider patient pop
expectorate any mucus that has been mobilized. ulation. It is relatively easy to learn in one or two ses
4. The series of PEP breaths followed by huffs sions, and may be applied equally to the pediatric and
should be repeated about four to six times. The adult populations. PEP is appropriate for use in hospi
total treatment lasts about 15 to 20 minutes and talized patients, as well as long-term use at home.
should be repeated twice to three times during The expense of the equipment is minimal and once
the day. The frequency and duration of the the patient is competent in the technique. it provides
treatment must be individualized for each pa independence (except for small children). All of the
tient. During periods of pulmonary exacerba PEP devices (the Flutter'" in particular) are quite
tion, patients are encouraged to increase the portable, making airway clearance easier to perform
frequency of PEP treatments, rather than ex during travel or when away from home during the day.
tending the length of individual s e s s i o n s Although rare, pneumothorax has been reported
(Mahlmeister, 1991). with high-pressure PEP (Oberwaldner, 1986). A deci
5. The procedure for use of high-pressure PEP sion to use PEP should be carefully evaluated in
differs from that of low-pressure PEP. The ex cases of acute sinusitis, ear infection, epistaxis, recent
piratory pressure used in this method usually oral or facial surgery or injury (Mahlmeister, 199/).
ranges between 50 and 120 cms of water pres For PEP therapy to be effective, a patient should be
sure. The patient breathes in and out through able to cooperate and actively participate with the
the mask at tidal volume for 6 to LO breaths, treatment. Pfleger (1992) recommends that patients
then inspiration is done to total lung capacity with airway hyperreactivity should take a bron
and a forced expiratory maneuver is performed chodilator premedication before the use of PEP.
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358 PART III Cardiopulmonary Physical Therapy Interventions
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20 Clinical Application of Airway Clearance Techniques 359
frequencies associated with the highest flow successfully in reclining patients who are unable to
rates were usually greater than 13 Hz, whereas tolerate the upright sitting position.
those associated with the largest volume were Use of HFCC may result in time savings at home
usually less than 10Hz. as well as in a hospital or long-term care facility.
2. The recommended protocol (American Biosys Nebulized medications are administered concurrently
tems, Inc., 1994) gives the option of intermit with the airway clearance treatment, and all lobes of
tent or continuous us· e . For the intermittent the lungs are treated simultaneously. The amount of
(only on exhalation) method, the patient should time for patient contact required for a hospital care
inhale deeply and depress the foot/hand control giver is much less with this method than with con
at peak inspiration. Exhalation should be pas ventional PD and percussion.
sive and relaxed while the vest is pulsating. For A disadvantage of this method of airway clearance
the continuous method, the foot/hand control is the cost of the equipment. A monthly rental fee is
should be depressed while breathing normally. reimbursed by most insurance companies. However,
At least once per minute, the patient should in a study by Ohnsorg (1994) demonstrated a decline in
hale to total lung capacity. t o ta l h e a l t h care costs for t h e y e a r a f t e r t h e
3. The average length of time spent at each fre ThAIRapy® Vest was put into use b y I I patients. A
quency is 3 to 5 minutes, but this will vary ac study of the impact of the device in a hospital setting
cording to patient tolerance, amount, and con (KIous, 1993) showed a substantial savings as a result
sistency of secretions, and the phase of the of therapy self-administration. A disadvantage of
patient's illness (acute or chronic). HFCC is its lack of portability. Although the device
4. After treatment at each frequency for the pre can be readily moved from room to room in the
scribed length of time, the foot/hand control house, i t does not accommodate use away from
should be released and the patient instructed to home.
huff or cough to clear loosened secretions. The In those patients for whom it is appropriate (and
control is adjusted to the next prescribed fre reimbursable), HFCC is an effective method of air
quency, and the procedure is repeated. way clearance. It provides independence for long
5. HFCC has been used on a smaller scale with term use at home as well as for acute exacerbations in
patients requiring long-term mechanical venti the hospital.
lation. Whitman et al. (1993) found use of the
ThAIRapy'M vest to be safe and effective, and
EXERCISE FOR AIRWAY CLEARANCE
resulted in time savings over conventional PD
and percussion. A regular program of exercise has been shown to im
6. Patients requiring central intravenous (IV) ac prove many variables in patients with lung disease.
cess such as a Porta-cath or Hickman are able Peak oxygen consumption, maximal work capacity,
to use the ThAIRapy"''' Vest with sufficient respiratory muscle endurance, and exercise tolerance
padding (such as a foam doughnut pillow) to all improve with an exercise program (Orenstein,
relieve pressure around the access site. 1981, Andreasson, 1987). Secretion clearance is also
improved with exercise (Zach, 1981; Oldenburg,
1979). Based on improvement in pulmonary function,
Advantages and Disadvantages of HFCC
exercise has been recommended as a replacement,
This method of airway clearance allows indepen partial or complete, for conventional chest physical
dence and is easy to learn in a short period. The therapy (PD and percussion) (Zach, 1982; Cerny,
ThAIRapy® Vest is now designed to accommodate 1989; Andreasson, 1987).
children as young as 3 years of age, and a vest may Exercise for secretion clearance has focused on
be custom-made for very large or obese adults. aerobic or endurance exercise to increase ventilation.
HFCC is appropriate with those patients in whom PD The many forms of exercise must be adapted to the
positions are contraindicated, and it has been used individual patient's status and abilities.
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360 PART III Cardiopulmonary Physical Therapy Interventions
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20 Clinical Application of Airway Clearance Techniques 361
TABLE 20·1
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362 PART III Cardiopulmonar)' Physical Therapy Interventions
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20 Clinical Application of Airway Clearance Techniques 363
In a home where more than one family member re The effectiveness of these newer techniques com
quires ongoing airway clearance, as can be the case for pared with more established methods are just begin
parents of children with cystic fibrosis, spending the ning to be studied. Health care providers have anec
least amount of time for the greatest benefit becomes of dotally reported their effectiveness, but long term,
primary importance. For an infant or young child, per well-designed studies are needed.
formance of secretion mobilization must be carried out
by an adult. As the child grows older and the choices of
INTRAPULMONARY PERCUSSIVE VENTILATOR (IPV)
a technique increase, close supervision remains neces
sary. In the adolescent, even when physical assistance The intrapulmonary percussive ventilator (IPV) (from
is no longer required, emotional support from family Percussionaire Corp., Sandpoint, Idaho) is an airway
and friends is paramount to continued success with a c l e a r a n c e device t h a t s i m u l t a n e o u s l y delivers
technique. Finally, the support received from health aerosolized solution and intrathoracic percussion
care providers is vital to the patient's motivation to con (Homnick, 1994). The functional component in the
tinue with a technique, or to learn a new one. IPY is an apparatus known as the phasitron. The pha
sitron was originally developed by Bird in 1979 for
the volumetric diffusive respiration (VDR) ventilator.
COST
It is used with thermally injured patients in place of
In this age of health reform, especially in long-term conventional mechanical ventilation. The VDR venti
care or chronic disease, cost of a treatment must be lator functions by accumulation of subtidal volume
considered. The initial cost of equipment, replace breaths, which build to an oscillatory equilibrium that
ment costs, and the expense of assistance required, all is followed by passive exhalation (Rodenberg, 1992).
figure into the total cost of treatment. Figure 20-18 shows a YDR ventilator waveform.
The generator for HFCC is the most costly piece In the IPV, the phasitron provides high-frequency
of equipment presented here, but replacement should impulses during inspiration, and positive expiratory
not be necessary. The vest itself should not require pressure maintained throughout passive exhalation.
replacement except for growth of a child. PEP masks The pressure generated is 10 to 30 cms. of water
and mouthpieces, and the FlutterT" are relatively inex pressure. Treatment with IPV is titrated for patient
pensive, with replacement of equipment expected to comfort and visible thoracic movement.
occur occasionally during a lifetime of use (more Homnick et a!. (1994) performed a 6-month study
often for a one-way valve in a self-made PEP). AD using the IPV for airway clearance in patients with
and ACB require no equipment. cystic fibrosis. No significant differences were
Payment of a trained assistant for home use of demonstrated in pulmonary function studies, body
postural drainage and percussion when family sup weight, use of antibiotics, or hospital days between
port is not available is at great expense. Depending the IPV and conventional chest physical therapy
on the duration and frequency of treatment, this cost group. Three fourths of the patients estimated in
may outweigh that for other airway clearance tech creased sputum production with IPY and satisfaction
niques on a long-term basis. was high for comfort and independence.
Often the choice of an airway clearance technique
is limited by the reimbursement available for equip
DYNAMIC AIR THERAPY BED
ment or assistance. Nonetheless, the caregiver must
strike a balance between economic and clinical con The E FICA CC'" Dynamic Air Therapy® bed (from
siderations in choosing a mode of therapy. HILLROM, Batesville, Indiana) is used in hospital
ized patients, primarily in an intensive care setting.
The modes available from the bed are continuous lat
FUTURE TRENDS IN AIRWAY CLEARANCE
eral rotation, percussion, vibration, and the ability to
A recent resurgence of interest in airway clearance position the patient in postural drainage positions.
has led to the introduction of additional techniques. Use of the bed demands less time of the caregivers
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364 PART III Cardiopulmonary Physical Therapy Interventions
11111AlII
1 AI IIIIHulI, llIlHIIH till, IAIlAllA
IUUIUU'IUV !nll,I"HUIVUU UU UlnllIHVIIVUI UUM uAflJUVIIIUVIIVVIIUI I
'II I" I" IlIUVIII' I" .JIII" I" II 'I m '" " .11
frI AI AI AI
11 I fI I' I "
\ I I
I, I,
'VY 'VIII 'YV ,yv
FIGURE 20-18
VDR ventilator waveform. (From Rodeberg, D.A., (1992). Decreased pulmonary barotrauma with
the use of volumetric diffusive respiration in pediatric patients with burns: The 1992 Moyer Award,
Journal of Burn Care Rehabilitation 13, 506-511.)
for hands on airway clearance treatment. presented by patients and choose a technique or combi
A smaJi pilot study by Samuelson et al. (1994) nation of techniques that best suits each patient's needs.
compared the bed to manual percussion and postural An individualized approach to airway clearance re
drainage in adult patients with cystic fibrosis. Patients quires consideration of the multitude of variables, both
were randomized to receive four treatments a day with physiological, psychological, and practical that affect a
either the Dynamic Air Therapy® bed or manual chest patient's response to treatment. Health care providers
physical therapy for I week and then switched to the are challenged to keep abreast of techniques and their
other modality for an additional week. Outcome mea modifications to best provide for the patient's needs.
sures included pulmonary function studies, 6-minute The role of the caregiver involves more than tech
walk distance, dyspnea score, and a Quality of WeJl nical expertise. The caregiver is uniquely positioned
Being Scale. Both therapies demonstrated a positive to simplify medical language for a patient and en
effect from baseline, but a significant improvement courage adherence to airway clearance. Support of a
was found only in the 6-minute walk distance of those treatment by a health care provider can increase the
patients treated with the bed therapy first. benefit derived from the treatment.
Studies on more appropriate patient populations, Further study is needed to compare and standardize
especiaJly nonambulatory, critically ill patients, for techniques, follow long-term outcomes, and establish
whom the Dynamic Air Therapy® beds are generally optimal treatment guidelines. This information will
prescribed, are necessary to demonstrate the most ef assist both patients and caregivers to maximize treat
fective use of this expensive equipment. ment with airway clearance techniques.
Numerous airway clearance techniques have been 1. Which ACTs can be performed without acquir
shown to reduce obstruction, enhance mucociliary ing additional equipment?
clearance, and improve ventilation, accomplishing the 2. Are there any ACTs that are not suitable for use
goal of improved oxygen transport. Their effectiveness in an intensive care unit?
has been demonstrated in controlled situations and eval 3. What are the airway clearance methods most
uated with sophisticated equipment. Caregivers must in suited for instructing a patient/family in during a
corporate this information into the real life situations single outpatient clinic visit?
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20 Clinical Application of Airway Clearance Techniques 365
4. What outcome measures do you have at your dis Gormenzano,J .• Branthwaite,M.A. (1972). Pulmonary physiother
apy with assisted ventilation. Anaeslhesia, 27, 249-257.
posal for evaluating the effectiveness of airway
Homnick, D., SpiJlers, e., White,F. (1994). The intrapulmonary
clearance?
percussive ventilator compared to standard aerosol therapy and
5. How would you encourage adherence of a pre chest physiotherapy in the treatment of patients with cystic ti
scribed method of airway clearance in: brosis. Abstracted in Pedialr Pulmonology, Suppl. 10,266.
• a fiercely independent adolescent with a spinal [mle, P.e., (1989). Percussion and vibration. In Mackenzie, (Ed.).
CheSi Physical Therapy in the Inlensive Care Unil, 2nd Ed.
cord injury?
(pp. 134-152). Baltimore: Williams & Wilkins.
• a 3 year old newly diagnosed with cystic fibrosis?
Kious,D.,et al. (1993). Chest vest and cystic fibrosis: Better care
• an older patient with bronchiectasis? for patients. Advanced RespiralOry Care Management, 3,44-50.
Kious, D.R. (1994) High-jrequency chest wall oscillation: Princi
ples and appiicalions. Published by American Biosystems,
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366 PART III Cardiopulmonary Therapy Interventions
SchonL M.H. (1989). Autogenic drainage: A modern approach to Cystic Fibrosis (CF). Published by International Physiotherapy
physiotherapy in cystic fibrosis. Journal of the Royal Society of Committee for Cystic Fibrosis (lPC/CF).
Medicine, suppl. 16,82,32-37. Webber, BA, Pryor, JA (1993). Physiotherapy skills: techniques
Steen, H.F., et aL (1991). Evaluation of the P E P mask in cystic fi and adjuncts. In Physiotherapy for Respirator\' and Cardiac
brosis. Acta Paediotr Scand, 80 (l), 51-56. Problems. Edinburgh: Churchill Livingstone,
Sutton, P.P., et aL (1985), Assessment of percussion, vibratory Whitman, J" et aL (1993). Preliminary evaluation of high-fre
shaking and breathing exercise in chest physical therapy. Euro quency chest compression for secretion clearance in mechani
pean Journal of Respirator'>' Diseases, 66, 147-152. cally ventilated patients. RespiralOly Care, 38 (10),1081-1087.
Warwick, WJ .. Hansen, LG (1991). The long-term effect of high Zach, M.5" Purrer, B., Oberwaldner B. (198 l). Effect of swim
frequency chest compression therapy on pulmonary complica ming on expiration and sputum clearance in
tions of cystic fibrosis. Pediwr Pulmonol, 1 1,265-271 11,1201-1203.
Webber, B,A, (1988). Physiotherapy for receiving me Zach, M" OberwaJdner, R, Hausler, F. (1982), Cystic
chanical ventilation. In Webber, B,A, (Ed,) The BromplOn Hos phYSical chest physiotherapy. Archives of Dis
pilal Guide 10 Chest Physiotherapy (Fifth Ed.). Oxford: Black eases of/he Child, 57. 587-589,
well Scientific Publications.
Webber, S" Pryor, J. (1993), Active cycle of breathing techniques.
In Bronchial Hypersecretion: Current Chest Physiotherapy in
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Facilitating Airway Clearance
With Coughing Techniques
Mary Massery
Donna Frownfelter
INTRODUCTION
Cough truly serves many purposes: a therapeutic technique, of food goes "down the wrong hole" or into the tra
a diagnostic signpost, and a social necessity. If it didn't al chea rather than the esophagus, a cough is not the
ready exist, we would have to invent it.
usual mechanism to clear mucus.
Glen A. Lillington, MD
A nervous cough or throat clearing may also sig
The cough is an interesting phenomenon. A cough nal that the airways are irritated, mucus is not clear
can either be a reflex or a voluntary action. Gener ing normally, or the person is in an uncomfortable
ally, in healthy individuals a cough is rarely heard situation. This is something to be aware of especialJy
unless the person has a cold or an irritant is inhaled when treating asthmatics, patients with cystic fibro
and a sneeze or a cough ensues to evacuate the for sis, or patients with psychological problems.
eign body. The mucociliary escalator functions to In reality the mucous blanket and the cough
clear secretions and inhaled particulate matter. Unless mechanism are the two ways the lungs have of pro
the mucus is very thick, such as in individuals with viding airway clearance under normal everyday cir
dehydration, inhalation of a foreign body, or a bolus cumstances.
367
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368 PART III Cardiopulmonary Physical Therapy Interventions
It is interesting how many people are unaware of Airway clea rance techniques, such as postural
their coughing. For example, when asked if they drainage, autogenic drainage, or active cycles of
cough, smokers with typical morning and ongoing breathing, need to be used to mobilize the secretions
smoker's coughs will deny that they do. Spouses will to the area where the cough will be effective (see
chime in, "He coughs and hacks all the time." An in Chapter 20).
dividual might constantly clear his or her throat and
swallow mucus but will claim to be unproductive of
COUGH ASSOCIATED WITH EATING OR DRINKING
mucus and free of coughing. It is important for thera
pists to be aware of both the reflex and voluntary na If a cough is associated with eating or drinking or
ture of their patients' coughs. taking medications, the patient should be evaluated
Frequent coughing or throat clearing may also in for a swallowing disturbance. This usually consists of
dicate other problems than airway clearance deficits. a "cookie swallow," a fluoroscopy study where the
For example, a patient may have postnasal drip from patient is given barium or a variety of consistency
a sinus infection or allergy. When the mucus drips liquids and solids to swallow and observed to see if
down into the back of the throat, it can cause a reflex aspiration into the respiratory tract occurs. Patients
cough to clear it. Other causes include bronchogenic may have dysfunction after a cerebrovascular acci
carcinoma, nervousness, and smoking. In a pediatric dent (CY A) or prolonged intubation or because high
patient, a foreign body or object inserted or inspired placement of a tracheostomy tube inhibits the proper
into the nose or airway should be ruled out. function of the larynx during swaJlowing. Speech
Cigarette smoking paralyzes the cilia so airway language pathologists working with patients with
clearance is altered. It has been noted that for every dysphagia can help patients learn techniques to pre
cigarette an individual smokes the cilia are paralyzed vent aspiration. They also help the patient and spouse
for approximately 20 minutes. Many individuals are (significant other) to understand cognitively proper
chain smokers and light up one cigarette after the positioning (usually sitting up in semi-Fowler's) and
other. Consequently, coughing is the only means of proper head and neck position (usually chin tuck and
clearing the lungs. This is understandable when a slight neck flexion) during swallowing. If a patient
smoker coughs up a large amount of mucus in the has dysphagia and cannot or will not follow a safe
early morning on arising. After sleeping for hours the swallowing retraining program and continues to
individual's cilia are able to clear secretions; a cough choke and aspirate food and liquid, aspiration pneu
assists in airway clearance. During the day the monia will occur and can lead to the patient's condi
smoker who chain smokes must cough regularly to tion deteriorating and even to death. In a situation
clear secretions because the cilia are paralyzed by the such as this, alternative feeding would need to be
smoke. considered.
One must appreciate the complexity and intricacy of The act of coughing can be hazardous to the patient.
the cough pump. Mucus is transported up against A patient should never be asked to cough repeatedly
gravity by the mucous blanket and propelled cepha as a routine part of treatment. The irritation and pos
lad by the action of the cough. sible narrowing of the airways during the forced ex
In general the cough is most effective at high expi halation may cause bronchospasm. If a patient is
ratory flow rates and at high volumes. The cough is sounding dry and unproductive, do not encourage fre
of limited value beyond the sixth or seventh genera quent coughing. This is especially true in patients
tion of airway branching. Consequently when a pa with asthma.
tient has a lower lobe pneumonia or atelectasis, If a patient demonstrates retained secretions on x
coughing alone will not clear the retained secretions. ray, encourage hydration (drinking water), use airway
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21 Facilitating Airway Clearance With Coughing Techniques 369
clearance mobilization techniques, and carefully eval for a forceful cough. Generally, adequate inspiratory
uate the cough. Instruct the patient in controlled volumes for a cough are noted to be at least 60% of
coughing when mucus is felt in the throat or upper the predicted vital capacity for that individual. The
airways. The patient may try to cough in a controlled second stage involves closing of the glottis (vocal
fashion after a postural drainage session or use the folds) to prepare for the abdominal and intercostal
forced expiratory technique. The forced expiratory muscles to produce positive intrathoracic pressure dis
technique uses midlong volume ventilation followed tal to the glottis. The third stage is the active contrac
by one to two huffs, which can include chest com tion of these muscles. The fourth and final stage in
pression with the arms. Forced coughing can also in volves opening of the glottis and forcefully expelling
crease blood pressure and Jower cardiac output. Tus the air. The patient should be able to cough three to
sive syncopy can occur when a patient goes into a six times per expiratory effort. A minimal threshold of
series of coughs in which the intrathoracic pressure a FEY) (forced expiratory volume in I second) of at
becomes so high that venous return to the heart is im least 60% of the patient's actual vital capacity is a
paired. The cardiac output falls and the patient be good indicator of adequate muscle strength necessary
comes very dizzy, progressing to unconsciousness. for effective expUlsion (Figure 21-1). During a cough,
Care must be exercised, especially with patients with alveolar, pleural, and subglottal pressures may rise as
primary lung disease; they must learn to control their much as 200 cm H20 (Bach, 1993; Jaeger, 1993; Lin
coughing to prevent untoward side effects. der, 1993).
There are four stages involved in producing an effec How do you assess whether a patient's cough is ef
tive cough (Linder, 1993). The first stage requires in fective? The answer appears to be obvious: ask the
spiring enough air to provide the volume necessary patient to cough. However, the obvious answer often
FIGURE 21-1
Cough mechanics. A, Stage I: adequate inspiration. B, Stage 2: glottal closure; Stage 3: b u i l ding up of intrathoracic and
intraabdominal pressure. C, Stage 4: glottal opening and expUlsion.
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370 PART In Cardiopulmonary Physical Therapy Interventions
does not adequately analyze the functional perfor inspiration or expiration cycle? Did the patient sponta
mance of a cough, especially for a neurologically im neously use trunk extension, an upward eye gaze, or
paired patient. The clinician must first take time to the arms to augment the inspiratory effOlt? Did the pa
set up the patient for successful evaluation of their tient take enough time to fully inspire before cough
cough. Guidelines for setting up the patient follow: ing? If the patient inspires adequately, he or she should
I. Do not ask the patient to cough in whatever be able to sustain two to six coughs per expiratory ef
posture you happen to find him or her in. Ask, fort for a cascade effect. Neurologically impaired pa
"What position do you like to cough in when tients who have inadequate inspiratory effol1s usually
you feel the need to cough?" Then ask the pa present with only one or two coughs per breath and
tient to assume that posture, or assist him or her generally produce a quieter cough (Hoffman, 1987).
in assuming a posture as close to the preferred
posture as possible. Listen closely to his or her
Stage 2: Glottal Closure
answers. A patient should s po n t a n e o u s l y
choose a posture that lends itself to trunk flex Did the patient hold his or her breath at the peak of
ion, which is necessary for effective expulsion inspiration before the expulsion phase or did the pa
and airway protection. A red flag or inappropri tient go directly from inspiration to expiration? Did
ate choice would be a preference for coughing you hear a cough or a huff? A huff (or a complete ab
while supine, which involves the opposite: sence of a hold between inspiration and expiration),
trunk extension and poor mechanical alignment when the patient intended to give you a cough, is an
for airway protection. indication of insufficient glottal closure. This can re
2. Now the patient is ready to demonstrate cough sult from a wide variety of situations including glottal
ing. Do not make the mistake of asking a pa edema after prolonged intubation, partial or full
tient to "show me a cough" or he or she may paralysis of the vocal folds, hemiparesis of the vocal
simply "show you" a cough. It may not be the folds, or timing or sequencing difficulty secondary to
way the patient coughs to clear secretions. In brain injuries to name a few. A complete lack of glot
stead continue to set the patient up for success tal closure will not produce any cough sound because
by asking him or her to "show me how you the vocal folds are not approximating.
would cough if you had secretions in your chest
and you felt the need to cough them out." With
Stage 3: Building up of Intrathoracic
these instructions you are asking the patient to
and Intraabdominal Pressure
show you something functional not theoretical.
Cough effectiveness can now be accurately as Did you see active contraction of the intercostal
sessed. Guidelines for objective evaluation with pul and abdominal muscles? D id the patient sponta
monary function tests have been indicted. This sec neously move into trunk flexion during this phase?
tion focuses on analyzing the movement during all Did the cough have a low resonant sound? Inade
four stages. An effective cough should maximize the quate force is usually heard as a higher pitch cough,
function of each individual stage. Thus the clinician often called a throaty cough. The sound is quieter
should see a deep inspiratory effort paired with trunk overall and does not produce as many coughs per
extension, a momentary hold, and then a series of ex expiratory effort. It is sometimes associated with
piratory coughs on a single breath while the patient neck extension rather than flexion as the patient at
moves into trunk flexion. tempts to clear the upper airway only. The air ap
pears to leak out rather than being propelled out of
the larynx during the cough. Like inadequate lung
Stage 1: Adequate Inspiration
volumes, inadequate pressure also prevents the pa
Did the patient spontaneously inspire a deep breath be tient from coughing more than once or twice on one
fore coughing or did he or she cough regardless of the expiratory effort.
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21 Facilitating Airway Clearance With Coughing Techniques 371
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372 PART III Cardiopulmonary Physical Therapy Interventions
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21 Facilitating Airway Clearance With Coughing Techniques 373
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374 PART III Cardiopulmonary Physical Therapy Interventions
helpful for lower airway clearance but does not di the heel of his or her hand, as in a Heimlich choking
rectly assist in upper chest clearance unless the pa maneuver. The patient is instructed to assist with ap
tient is able to move his or her upper body indepen propriate trunk movements to the best of his or her
dently while the therapist assists the lower chest. This ability. TechnicalJy, this procedure is very effective
technique is easy to learn and teach and can usually at forcefully expelling the air (Braun, 1984), as in a
be used from the acute phase through the patient's re cough, but it can be extremely uncomfortable for the
habilitation phase, thus accounting for its popularity. patient because of (1) its concentrated area of contact,
(2) the abrupt nature, which may elicit an undesired
Heimlich-type assist or abdominal thrust assist
high neuromuscular tone response or worse when
The second technique, the Heimlich-type assist or an combined with the sensory input that the therapist's
abdominal thrust, requires the therapist to place the manual contacts supply, (3) the force, which may
heel of his or her hand at about the level of the pa cause an abdominal herniation. Because of its limited
tient's navel, taking care to avoid direct placement on usefulness, the Heimlich type of assist or abdominal
the lower ribs (Figure 21-3). After appropriate posi thrust should only be used when the patient does not
tioning, the patient is instructed to "take in a deep respond to other techniques and the need to produce
breath and hold it." Unfortunately, manual facilita an effective cough is imminent. Patients with low
tion of inhalation is not feasible with this technique. neuromuscular tone or flaccid abdominal muscles
As the patient is instructed to cough, the therapist fare best with this procedure.
quickly pushes up and in, under the diaphgram with
FIGURE 21-3
Hand position for Heimlich-type assist or abdominal thrust.
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21 Facilitating Airway Clearance With Coughing Techniques 375
The therapist can simultaneously use both of the enhance the first two cough stages. The therapist then
above techniques in sidelying. If the patient is hemi applies a quick force through both arms to simulate
plegic or suffered from an unilateral lung or thorax the force necessary during the expulsion phase. The
disease or trauma, emphasizing one side of the thorax directions of the force are (l) down and back on the
over the other may be an appropriate focus during upper chest, and (2) up and back on the lower chest
airway clearance treatments. One upper extremity is or abdominal arm. Performed together the compres
used to perform the Heimlich"type of assist while the sion force from both arms makes the letter V.
other does an uni lateral costophrenic assist. In this The anterior chest compression technique is more
manner the therapist can compress simultaneously all effective than the costophrenic assist for patients with
three planes of ventilation in the lower chest. The very weak chest wall muscles because of the added
possibilities of combining techniques and positions compression of the upper anterior chest wall. These
are almost endless once the therapist understands the authors have found sidelying or 3/4 supine position to
principles on which they were developed. be the most effective position for this technique.
However, the anterior chest compression technique is
Anterior chest compression assist not appropriate for patients with a cavus condition of
The third assistive cough is called the anterior chest the upper anterior chest because it promotes further
compression assist, since it compresses both the collapsing of the anterior chest wall.
upper and lower anterior chest during the coughing
maneuver. This is the first single technique thus far to
Counterrotation assist
address the compression needs of the upper and The most effective assistive cough for the widest
lower chest in one maneuver. The therapist puts one cross-section of neurological patients, in these au
arm across the patient's pectoralis region to compress thors' clinical experience, is the fourth and final
the upper chest and the other arm is either placed par method described in sidelying, the counterrotation as
allel on the lower chest or abdomen (Figure 21-4) or sist. The positioning and procedures required for the
placed like in the Heimlich type of maneuver (Figure counterrotation technique are described in detail in
21-5). The commands are the same as in the other chapter 22 and apply for both the patient and the ther
techniques. Because of the direct manual contact on apist (Figure 21-6). The therapist should recall that
the chest, inspiration can be easily facilitated first, orthopedic precautions of the spine, rib cage, shoul
followed by a "hold." Thus the therapist can readily der, and pelvis still persist for this technique.
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376 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 21-6
Counterrotation assist; A, Hand placement during expulsion phase; B, Hand placement during
inspiration phase.
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21 Facilitating Airway Clearance With Coughing Techniques 377
The therapist begins by following the patient's tion before passively coughing in a comatose
breathing cycle with his or her hands positioned over patient can reduce high tone and frequently re
the patient's shoulder and pelvis (see Figure 21-6). duce a high respiratory rate. Both of these re
The therapist then gently assists the patient in inhala duce the possibility of the patient keeping his
tion and exhalation to promote better overall ventila or her glottis closed during the expulsion phase.
tion. This sequence is generally repeated for three to 2. Counterrotation is an excellent mobilizer for a
five cycles or until the patient appears to have tight chest, which in itself can facilitate sponta
achieved good ventilation to all lung segments. neous deeper breaths. Tidal volumes (TVs) can
At this point, the patient is ready to begin the therefore be increased for many patients by mo
coughing phase of the procedure. The patient is bilizing the chest walls.
asked to take in as deep a breath as possible with the 3. Finally, rotation can be a vestibular stimulator
therapist assisting the patient in chest expansion and may assist in arousing the patient cogni
(see Figure 21-6, 8). The patient is then instructed tively, allowing him or her to take a more ac
to "hold it" at the end of maximal inspiration. The tive role in the procedure.
patient is then commanded to cough out as hard as The true beauty of the technique is the fact that no
possible while the therapist quickly and forcefully active participation on the part of the patient is re
compresses the chest with his or her hands in their quired for success. Incoherent or unresponsive pa
flexion phase positions (see Figure 21-6, A). tients, such as those patients with low functioning
The importance of following a true diagonal plane following a head trauma, CVA, or cerebral palsy, will
of facilitation during both the flexion and extension still demonstrate good secretion clearance with this
phases of this technique cannot be overemphasized. technique. The mechanics of the procedure dictate
Failure to do so will result in shifting of the air within that the air within the lungs be rapidly and forcefully
the chest cavity rather than the desired forcing out. expelled regardless of the patient's level of active
This air shifting can occur to varying degrees, when participation. Obviously, patient participation is de
the upper and lower chest are not used together, as in sirable to clear secretions even more effectively and
all the other assistive cough techniques. When done for teaching the patient to eventually clear his or her
properly, the counterrotation assist is the only one to own secretions, but it is not critical.
rapidly close off the chest cavity in all three planes of Clinical experience has demonstrated with patients
ventilation in all areas of the chest. Unless the patient who have extremely tenacious secretions, use of vi
voluntarily closes his or her glottis, it is impossible to bration instead of quick chest compression during the
withhold the air from being forcefully expelled. cough itself may be more effective. This prolongs the
However, a common mistake made by the therapist is cough phase and gives the secretions time to be
pulling the patient back into trunk extension during moved along the bronchi for successful expUlsion.
the expUlsion phase rather than into trunk flexion. A These patients may also require a series of three or
good rule of thumb: if you can see your patient's face four cough cycles before clearing most of their secre
when you are applying the compression force, you tions. In general, patients from all the diagnostic
have pulled them into extension. The head and neck groups discussed thus far with or without good cogni
should stay forward and flexed, thus only a facial tive functioning are appropriate for this procedure.
profile should be seen. The majority of them find it to be the most comfort
Other effects of countcrrotation make this proce able and effective assistive means of expectorating
dure particularly beneficial to patients with low levels secretions.
of cognitive functioning.
I. The rotation component is a natural inhibitor of
Self-assisted Techniques
high tone. Thus this is the least likely of all
techniques discussed so far to elicit an increase The coughing techniques d iscussed in this section
in abnormal tone during the coughing phase. In are intended to be used as self-assisted procedures,
fact the opposite usually prevails. Gentle rota thus usually taught later in a patient's rehabilitation
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378 PART III Cardiopulmonary Physical Therapy Interventions
process. Five different techniques will be presented capitalize on the functional increase in chest expan
in detail. Suggestions for variations are included. sion and compression abilities. For the population of
All self-assisted cough techniques can start out as patients who can assume a prone on elbows posture
physically assisted techniques; however, because independently (i.e., some patients with tetraplegia),
they are more active and require greater gross motor this t ec hniquc may be used functionally. Here, they
movement, they lend themselves to self-assisted can assist their own coughs when the need arises,
techniques. rather than wait for someone to assist them in a posi
tion change.
Prone on elbows head flexion self-assisted cough The head flexion assist requires good use of head
Prone is not frequently used as a posture for coughing and neck musculature, scen in patients sustaining a
because the position itself inhibits fuJI use of the di spinal level injury below C4 (e.g., spinal cord injuries
aphragm by preventing lower anterior chest and ab (SCIs), spina bifida). It can be used either as a self
dominal excursion following a neurologic insull. This assisted or therapist-assisted procedure, using the
forces the patient to use an alternate breathing pattern principles of trunk extension to facilitate inspiration
that facilitates greater accessory muscle use. Because and trunk flexion to facilitate expiration. With the pa
this change in breathing patterns often occurs sponta tient prone on elbows, the therapist instructs him or
neously, prone on elbows can be an effective posture her to bring the head and neck up and back as far as
for promoting spontaneous use of the accessory mus possible, breathing in maximally (Figure 21-7). The
cles in a more difficult activity (coughing). However, patient is then instructed to cough out as hard as pos
without the full use of the diaphragm, the resultant sible while throwing the head forward and down
cough will be weaker than in other postures. Prone on (Figure 21-8). This head-and-neck pattern can be ini
elbows should not be the exclusive posture for assist tially assisted by the therapist to establish the desired
ing a cough. After mastering the timing of the proce movement pattern, and gradually progressed to a re
dure, most patients move back to another posture, sisted pattern to promote increased accessory muscle
usually sitting or sidelying, and to other techniques to participation and to strengthen those muscle groups.
FIGURE 21-7
Head flexion assistive cough in prone on elbows; extension and inspiratory phase.
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21 Facilitating Airway Clearance With Coughing Techniques 379
FIGURE 21-8
Head flexion assistive cough in pTone on elbows; flexion and coughing phase.
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380 PART III Cardiopulmonary Physical Therapy Interventions
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21 Facilitating Airway Clearance With Coughing Techniques 381
FIGURE 21-13
Assisted cough in short sitting. A, Hand
position for patient with good hand function;
B, Hand position for patients with only wrist
function.
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382 PART III Cardiopulmonary Physical Therapy Interventions
....
occur?
L . .! _ 6. What are the stages of a cough?
-
I. . '
't . 7. What should the therapist interpret when a pa
tient's cough is associated with eating or drink
I .
:: ing?
8. What effect does coughing have on the blood
pressure and cardiac output?
9. What special techniques can be taught to asth
matic patients to mobilize secreations?
10. What manual techniques are most effective in
FIGURE 21-15
spinal cord patients?
Assisted cough in hands-knees position; flexion or
coughing phase.
References
Standing self-assisted cough Bach. J.R. (1993). Comparison of peak expiratory flows wilh man
Standing uses the same concepts and can be readily ually assisled and unassisled coughing techniques. Chest
104(5): I 553-{i2.
used for self-assisted coughs, provided the patient has
Braun. S.R.. Giovannoni, R., & O'Connor, M. (1984). Improving
adequate standing balance and/or upper extremity
cough in patients with spinal cord injury. American Journal of
support. Use any technique previously described and Physical Medicine 63( I): 1-10.
modify for this higher developmental posture. Com Estenne, M .. Detroyer, A. (1990). Cough in letraplegic subjects: an
binations of trunk, head, and extremity movements active process. Annals of Internal Medicine 12(1):22-28.
Fishburn, M.J.. Marino, R.J., & Dittuno, J.F. (1990). Alelectasis
during the cough maneuver is almost endless, thus
and pneumonia in acute spinal cord injulY Archives of Physical
specific techniques are not itemized.
Medicine and Rehabilitation 71: 197-200.
Hoffman, L.A. (1987). Ineffeclive airway clerarance related 10
Copyrighted Material
Facilitating Ventilation Patterns
and Breathing Strategies
Mary Massery
Donna Frownfelter
INTRODUCTIOtJ
tient. No single technique is appropriate in all cases.
Attaining optimal ventilatory patterns requires the use Sound clinical judgment and experience must be exer
of a variety of techniques. Some are passive in nature, cised when applying these ideas with each patient. It
such as passive positioning of the patient or applica is the hope of these authors that the techniques identi
tion of an abdominal binder for better diaphragmatic fied in this chapter will stimulate the clinician's cre
positioning. Some require very active participation on ative talents, and that they will extrapolate and im
the part of the therapist and/or patient, such as in as prove on the techniques according to specific patient
sisted-cough techniques or in glossopharyngeal population needs. See the box on next page for spe
breathing instruction. Other techniques are subtly in cific areas covered in the chapter.
corporated into the patient's total physical rehabilita
tion program, requiring little overt attention to the pa
POSITIONING CONCERNS
tient's respiratory performance, such as when using
ventilatory strategies. All of these diverse aspects of All patients spend some portion of the day in a hori
treatment play an important role in the total develop zontal position for rest or sleep. Using this opportunity
ment of a successful respiratory rehabilitation pro to assist the patient in passive drainage of lung secre
gram for the neuromuscular and musculoskeletal pa tions is a natural beginning in the development of a pa
383
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384 PART III Cardiopulmonary Physical Therapy Interventions
2. Ventilatory and movement strategies advantage of breathing. For example, patients with
spinal cord injuries (SCIs) resulting in tetraplegia
3. Manual facilitation techniques
will be unable to support their intestinal contents
• Fac i l i tating contr olled breathing patterns
properly under the diaphragm to al]ow for maximal
(diaphragmatic)
expansion of the chest in all three planes of ventila
• Mobilizing the thorax
tion (see Chapter 37). Use of an abdominal support
Facilitating upper chest breathing patterns
from the iliac crest to the base of the xiphoid process
•
(accessory muscles)
provides positive pressure support to restore intesti
Promoting symmetrical breath ing patterns
nal positioning in an upright position (Figure 22-1).
•
(unilateral dysfunction)
Research has documented well the significant im
Reducing high respiratory rates
provements in vital capacity, inspiratory capacity,
•
4. Glossopharyngeal breathing and tidal volume in sitting with use of a strong ab
S. Enhancing phonation skills dominal support. These binders have also been used
in nursing care to provide for better circulation and
in the prevention of hypotension.
The abdominal binder's value in cosmesis may be
underrated. Many of these neurological patients were
tient's long-term respiratory program. Specific pos once normal, healthy individuals with high self-es
tural drainage positions are covered extensively in this teem who took great pride in their appearances. They
book (see Chapter 21). Using a combination of these now present with a protruding belly (the anterior and
positions in your patient's bed position rotation, in the infelior shift of the intestines resulting from flaccid
hospital, or at home can help to achieve multiple goals. abdominal muscles), which may be psychologically
First, they can assist the patients in clearing secretions disturbing to them. Thus the use of a binder may
passively that they may have difficulty performing ac greatly aid in the restoration of that person's self-es
tively. Second, these position changes provide for skin teem, which should be a high-priority goal in any re
relief and better circulation. Finally, they assist in re habilitation program.
tarding the development of joint contractures or other A rigid type of abdominal support can be used
musculoskeletal abnormalities. A four-position rota when the vertebral column and the abdominal viscera
tion (i.e., supine, prone, side-to-side) is usually an ef need support. These are called body jackets or total
fective and reasonable means of incorporating these contact thoracic lumbar sacral orthosis (TLSOs).
goals into a long-term prophylactic program. (Figure 22-2). A TLSO is a rigid trunk support
Simple adaptations may make ventilation easier in molded individually to the shape of the patient's en
each of these postures. For example, in supine, plac tire trunk from the axilla down to the pubis. It is
ing the arms lip over the patient's head facilitates made up of two separate front and back pieces, with
'
greater anterior upper chest expansion. Likewise, po an anterior cutout in the abdomen to allow for normal
sitioning the pelvis in a slight posterior tilt facilitates diaphragmatic displacement of the viscera. Many of
more diaphragmatic excursion. See Chapter 40 for these jackets also use a strong elastic support across
more detailed explanations. Observation of all pre the cutout to allow for diaphragmatic motion but to
cautions and contraindications to passive positioning minimize excessive displacement of the abdominal
is still warranted. contents. This is very appropriate for the growing
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22 Facilitating Ventilation Patterns and Breathing Strategies 385
"
FIGURE 22-1
A, Abdominal binder-Velcro fastener. B, placement of
abdominal binder.
child who needs more spinal stability or the com as well as many other areas of rehabilitation, depends
pletely flaccid tetraplegic patient who may also re on good alignment of the body against the forces of
quire the same support. Because head and neck posi gravity. Symmetry must be strived for through the
tioning are so interdependent on trunk positioning, a use of a body jacket, lateral trunk supports in the
body jacket may be the difference to these patients wheelchair, abdominal binders, or some other means
between being dependent or independent in an up (Figure 22-3). This is especiaJly important for pa
right posture. It may result in significantly better head tients with hemiplegia where habitual asymmetrical
control, eye contact, longer phonation, and possibly posturing leads to musculoskeletal problems later.
better articulation. However, because it limits trunk Symmetrical breathing patterns and uniform aeration
movement, its usefulness for each patient must be as of all lung segments are augmented by careful up
sessed carefuII y. right positioning. Therefore everything from the type
Logically, the next consideration under passive of neck support to the height and width of the arm
respiratory techniques is proper wheelchair position rests to the length and type of the foot supports must
ing. Optimal performance in respiratory functioning, be carefully analyzed for each patient.
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386 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 22-2
A, patient with CS congenital tetraplegia independent long sitting. B, long sitting with body jacket
support. Note changes in head position and eye contact, hip alignment, and shoulder rotation.
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22 Facilitating Ventilation Patterns and Breathing Strategies 387
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388 PART III Ca.-diopulmonary Physical Therapy Interventions
eye gaze. Accordingly then, the simple task of pas nity to learn from the beginning of his or her rehabili
sive range of movement (ROM) can easily include tation process that movement and breathing go hand
the active goal of increasing ventilation by asking the in hand. C1inicaJly, incorporating appropriate breath
patient to breathe in and look up every time his or her ing pattems with movement early in the rehabilitation
arm is raised up into shoulder flexion. This encour process discourages the development of Valsalva pat
ages the patient to breathe in when his or her chest tems or shallow breathing pattems when the motor ac
wall muscles are being maximally stretched and the tivities become more difficult and complex.
ribs are naturally opening up, causing both activities
to be more successful. It also begins to teach the pa
Dynamic Activities
tient to use ventilatory strategies to optimize potential
functional movement, such as in reaching up to a Inhalation promotes trunk extension and exhalation
kitchen cabinet. promotes trunk flexion and vice versa. This basic
theme occurs naturally in all motor activities but
Expiration may have ceased to become spontaneous after a
Likewise, active or passive exhalation should be co neuromuscular or musculoskeletal insult. Valsalva
ordinated with the reverse upper extremity ROM pat maneuvers during transitional movements, such as
tern (i.e., the arm returning from flexion back to the rolling or coming to sitting or standing, are often
patient's side). This can be done using all types of ex noted with these patients. By teaching them strate
halation patterns, including the following: (1) passive gies that incorporate breathing into their motor
quiet exhalation, (2) forceful exhalation as in blow plans for all motor activities, Valsalva patterns can
ing, coughing, or pursed-lips exhalation, or (3) vocal be eliminated or minimized while simultaneously
ization patterns. Thus the therapist may ask the pa promoting beller cardiac function.
tient to slowly count out loud to 10 while the arm is Every activity of daily living cannot be described
being returned to his or her side. Subconsciously, the in this book, however, suggestions for typical gross
patient learns to correlate exhalation with shoulder motor activities using ventilatory strategies as a
extension while simultaneously learning a much means to improve these motor tasks are presented.
more complex idea-that of controlling his or her Extrapolation of these concepts to all other motor ac
rate and volume of expiration by including deliberate tivities should be carefully analyzed by each therapist
speech during exhalation maneuvers. for each individual patient.
To improve exhalation potential, increase the pa
tient's relative trunk flexion alignment. While sti II
Rolling
supine and performing upper-extremity ROM, this Ask patients to attempt to roll and assess whether
can be simply accomplished by asking the patient to they tend to move with trunk extension or flexion to
lift his or her head and watch the hand as it returns to begin the roll. If they roll with a trunk extension pat
his or her side, which increases abdominal and inter tern ask them to breathe in while they roll and to look
costal activation, or by increasing knee flexion, up. If they roll with trunk flexion as their primary
which increases posterior pelvic tilting and trunk movement pattern, instruct them to roll while blow
flexion. Pairing trunk flexion with exhalation com ing out and tucking their chin. In doing :\0, patients
pletes the ventilatory-trunk movement strategy. work with, not against natural whole patterns of
Combining positioning with respiratory verbal movements to increase the likelihood of success.
ROM activities, changes passive
cues, as described in
upper-extremity ROM exercises to dynamic upper-ex
Coming up to sitting
tremity ROM exercises. It encourages increased inspi Pushing up to sitting from sidelying should be evalu
ratory and expiratory capacities, develops early func ated in much the same manner. If patients are more
tional motor planning strategies, and facilitates trunk effective in coming upright when using trunk exten
mobility. In this manner the patient has the opportu sion, have them inhale as they push up to sitting.
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22 Facilitating Ventilation Patterns and Breathing Strategies 389
Asking them to "look up" as they move will reinforce independent one. Returning to sitting should be ac
the upper chest movements through the use of the companied with slow controlled exhalation, such as in
symmetrical tonic neck reflex (STNR). If they have pursed-lips blowing or counting out loud, to maximize
more success pushing up with trunk flexion, have the body's controlled descent into gravity's influence.
them blow out and tuck the chin while moving.
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390 PART III Cardiopulmonary Physical Therapy Interventions
Hyperpnea-Increased breathing. usually refers to increased tidal volume with or without increased frequency
Hyperventilation-Increased alveolar ventilation in relation to metabolic rate (an increase in alveolar ventilation
seen is a decrease in the arterial Peo2
Cheyne-Stokes respiration-Cycles of gradually increasing tidal volume followed by gradually decreasing tidal
volume (usually followed by an apneic period)
Biot's respiration-Sequences of uniformly deep gasps and apnea, followed by deep gasps
Adapted from Comroe. J. H .• Jr. (1974). Physiology 0/ respiration, (2nd ed). SI. Louis: Mosby.
• Apprehension or nervousness
• Restriction of inspiration resulting from musculoskeletal dysfunction such as scoliosis. kyphoscoliosis, pectus ex
cavatum, obesity, pregnancy, pulmonary pathology such as fibrosis, scarring from radiation therapy. neurological
weakness such as spinal cord injury. Parkinson's disease, or myasthenia gravis
• Rib fractures
• Debilitated or bedridden patients that tend to have constant volume ventilation, retain sel:relions. and are prone to
pneumonia and atelectasis from poor airway clearance
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22 Facilitating Ventilation Patterns and Breathing Strategies 391
• To enable patients to feel self-control and confi breathing, see Chapter 37). In these cases the goal is
dence in managing disease or dysfunction
to teach them to use the accessory muscles to balance
the upper and lower chest. This facilitates an increase
in vital capacity to prevent atelectasis and pneumonia
tilatory strategies and breathing-control techniques by increasing the volume of ventilation and improv
can be the key to maximizing potential. See the box ing the cough mechanism.
above for a list of goals in teaching controlled-breath The choice of appropriate venti latory strategies
ing techniques. depends on the patient's individual problem. The fol
Breathing control has long been used in yoga to lowing questions should be considered when evaluat
foclls and promote meditation. This is a key to maxi ing patients:
mizing rehabilitation. If you can not breathe you can
Does the patient have more difficulty in inspira
not function! It is of primary importance to assess the
tion or exhalation?
patient's breathing at rest and during exercise. We
•
Is there a normal sequence to inspiration (i.e., ab
often hold our breath with exertion, especially with
dominal wall rises, then mid chest, then upper
new activities. We must assess the cardiopulmonary
chest, with a full inspiration? Or does the chest
and neuromuscular response to each new activity.
sink and the abdomen rise on inspiration?
•
Does the patient appear to be working hard to
CONSIDERATIONS FOR TEACHING BREATHING breathe? Is the patient using the accessory muscles
CONTROL TO PATIENT'S WITH PRIMARY VERSUS to an extreme?
SECONDARY PULMONARY DYSFUNCTION •
Does the patient have trouble coughing or speak
ing a normal volume and for the normal length of
Patients with primary lung disease, such as emphy
sentences?
sema, asthma, bronchitis, or cystic fibrosis, present a
•
Is ventilation the limiting factor in accomplishing
much different picture than patients with spinal cord
' an activity (i.e., transfer, gait, or bed mobility)?
injury, Parkinson's disease, myasthenia gravis, or
Guillain-Barre syndrome. Patients with primary pulmonary disease generally
In general, patients with primary lung disease use benefit from ventilatory strategies that relax the ac
their accessory muscles and greatly increase the work cessory muscles and facilitate relaxed diaphrag
of breathing secondary to the shortness of breath or matic breathing.
coughing. They often complain that they have more On the other hand, patients with secondary pul
difficulty "getting air out," which demonstrates the monary dysfunction usually benefit from the balanced
decreased expiratory flow rates noted on pulmonary use of the diaphragm and accessory muscles to in
function tests. The goal with these patients is to teach crease vital capacity and breath support for activities.
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392 PART III Car·diopulmonary Physical Therapy Interventions
2. Re patterning techniques
6. Upper chest inhibiting technique Often the patient's posture and pelvic position has a
dramatic effect on breathing. In general, a slight, rela
7. Normal timing technique
tive posterior tilt of the pelvis facilitates diaphrag
matic breathing and a relative anterior tilt facilitates
opening of the anterior chest and upper chest breath
FACILITATING DIAPHRAGMATIC BREATHING
ing. It is helpful to see what difference a slight, rela
This section is laid out starting with the easiest interven tive change in pelvic position will do to the patient's
tion to facilitate diaphragmatic breathing and progress ability to ventilate. This is especially true with sec
ing to specific inhibition and facilitation techniques. ondary pulmonary problems related to neurological
See the box above for a summary of methods to and neuromuscular dysfunction.
facilitate diaphragmatic ventilation patterns.
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22 Facilitating Ventilation Patterns and Breathing Strategies 393
REPATTERNING TECHNIQUE
rotation), and (4) choosing to use a pillow or pillows
If a patient needs more support to gain control of breath under the head. (For details on positioning, see Chap
ing and is experiencing shortness of breath, a simple ter 40.) For each patient, choices will be different (i.e.,
repatterning technique is very beneficial. An example the amount of knee flexiol1 or the number of pillows).
might be an asthmatic patient with a high respiratory Find the right combination of positioning characteris
rate who is feeling panicky. When the patient is asked tics that best facilitates diaphragmatic movement for
why he or she is breathing so fast the reply will usually that particular patient. In this manner the therapist sets
be, "I am n ot getting enough air, I can't catch my up the patient for respiratory success before beginning
breath." The patient is asked to start with exhalation. the manual or verbal techniques.
"Try to blow out easily with your lips pursed. Don't Now, begin the techn ique. A s k the patient to
force it just let it come out." By doing this, the respira place his or her hands on their stomach for increased
tory rate will automatically be decreased. When the pa proprioceptive feedback and the relative extension,
tient feels some control of this step, then ask him or her adduction, and internal rotation position of the shoul
to "hold the breath at the top of inspiration just for a sec ders. In a quiet melodic voice, ask the patient to
ond or two." Make sure the patient does not hold his or "sniff in 3 times." Note if the patient demonstrates
her breath and bear down as in a Valsalva maneuver. more abdominal rise and/or lower chest expansion . If
Lastly, ask the patient to take a slow breath in, hold it, so, draw attention to this fact. During exhalation, tell
and let it go through pursed lips. Patients often learn that the patient to "let it out slow," which helps to inad
when they are short of breath, this technique will help vertently slow the respiratory rate (RR) and often en
them gain control, making them feel less panicky. courages some relaxation. Progress the training by
asking the patient to "now sniff in twice." Do you
still see greater diaphragmatic excursion and less
Sniffing
upper chest excursion? If so, continue by asking for
If working toward a generalized controlled-breathing "one long slow sniff." If successful, the therapist
pattern does not improve the patient's ventilatory pat should follow with: "now do it quieter," then "now
tern adequately, a technique that more specifically do it slower," "even quieter," and so forth. By this
addresses the n eed to initiate breathing from the di time, the patient should be demonstrating an easy
aphragm can be attempted. Sniffing is a simple and onset, slow RR, diaphragmatic pattern with relaxed
effective means of teaching increased diaphragmatic shoulders.
breathing. Sniffing is primarily diaphragmatic breath Clinical experience has shown this technique is
ing by nature. Use this technique first when attempt highly successful with about 80% of patients who
ing more specific diaphragmatic training with all pa have primary pulmonary pathologies or neurological
tients who are capable of attempting sniffing because impairments. The key to success seems to stem from
of its simplicity. the relaxed tones and words that the therapist uses,
As with all procedures, the most imp0l1ant step is which decrease anxiety and imply relaxation and not
the first step: position the patient appropriately to in "effort." Once the pattern has been established, the
crease the likelihood of increased diaphragmatic patient can easily be instructed to go through the
breathing resulting from musculoskeletal alignmel1t. training as needed indepen dently. The sequence (in
This includes the following: (I) choosing a gravity whole or in part) may be appropriate for patients be
eliminated position, such as sidelying, or a gravity-as fore getting out of bed if they become anxious and
sisted position, such as supported semi-Fowler's sit demonstrate excessive upper chest breathing during
ting (supported spin e), (2) choosing a relatively this activity. For other patients, it may be appropriate
posteriorly tilted pelvis with flexed knees, (3) choos before or during eating or before climbing stairs. Ob
ing the arms to be down below 90 degrees of flexion viously, the application of this technique will be indi
(in relative shoulder extension, adduction, and internal vidualized for each patient, depending on the deficits.
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394 PART III Cardiopulmonary Physical Therapy Interventions
j ""f f !
/
I! /, J ))
diaphragmatic breathing using the scoop technique. It )' -::0.. ,,/
, "-
r 1
The following is a suggested sequence:
1. Position the patient for success, generally in a
s i d e l yi n g p o s i t i o n w i t h t h e b e d in s e m i
Fowler's or supine in semi-Fowler's with a
FIGURE 22-4
bend in the knees to achieve a relative posterior
Therapist's hand placement for diaphragmatic breathing.
pelvic tilt and relax the abdominal muscles.
2. Place your hand on the patient's abdomen at
the level of the umbilicus. Tell the patient you perventilate and blow off too much CO2. The fact
want to feel his or her breathing. Follow the pa that they are breathing more with their diaphragms is
tient's breathing pattern for a few cycles until the important consideration. Note also the position of
you are in his or her rhythm. Do not invade the the pelvis and trunk.
patient's breathing pattern rather, at first, fol When the patient has mastered the breathing pat
low their movement. tern in sidelying, try supine. Then progress to sitting
3. After the nonnal rate at the end of the patient's (Figure 22-6), standing (Figure 22-7), walking (Fig
exhalation, give a slow stretch and "scoop" your ure 22-8), and finally stairs (Figure 22-9). Each de
hand up and under the anterior thorax as shown velopmental position increases the difficulty in per
in Figure 22-4. The command, "Breathe into my forming diaphragmatic breathing. In sidelying or
hand," is given as the slow scoop stretch is done. supine the patient is fully supported. The sidelying
4. As the "scoop stretch" is performed instruct the position is especially good for initially teaching di
patient to, "breathe into my hand" during the aphragmatic breathing because the diaphragm is in a
inspiration. Give a scoop at the end of exhala gravity-eliminated position. In supine the patient
tion with each breath. The verbal command can must breathe up against gravity. However, as we
be effectively replaced with audible breathing progress to sitting, the patient must now provide
to facili tate the ventilatory pattern if verbal trunk support and maintain stability up against grav
cues are ineffective or inappropriate. ity, as well as relax the shoulders. In standing the en
5. After achieving some success, it is helpful to tire body must be supported, and when walking or
call the patient's attention to the awareness of stairs are added, the element of breathing coordina
the breathing pattern. For example, the thera tion really comes into play.
pist can ask, "Can you feel how your abdomen Coordination of breathing for walking involves
rises as you breathe in?" being careful not to allow patients to breath hold. They
6. The patient's hand can be placed on the ab need to keep inspiration and exhalation regular at least
domen with the therapist's hand on top. Rein at a ratio of 1'1, preferably exhaling a little longer.
force the breathing pattern, then remove your In general the preferred pattern for patients with pri
hand and allow the patient to independently mary pulmonary dysfunction is as follows: (I) Pause at
feel the ventilatory pattern (Figure 22-5). the base of the stairs to gain controL (2) Have the pa
A few things should be taken into consideration. Try tient take a breath in and move as he or she exhales up
not to have patients take too many deep breaths; they one stair. (3) The patient then pauses to inspire and ex
may begin to feel light-headed because they may hy hales as he or she walks up one stair. (4) The patient
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22 Facilitating Ventilation Patterns and Breathing Strategies 395
diaphragmatic breathing to become aware of his breathing retraining. Note the relaxed position of the patient's
pattern. this is usually the first position of the shoulders and hands.
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396 PART III Cardiopulmonary Physical Therapy Interventions
C1 0f
-- \y
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22 Facilitating Ventilation Patterns and Breathing Strategies 397
RGURE22 1 RGURE22 2
Bilateral midchest expansion exercise. Self-assisted bilateral chest expansion exercise. Keep the
patient's shoulders relaxed.
l
j 1
----" ,-"I{
FIGURE22-13 FIGURE22-14
Bi lateral posterior chest expansion exercise. Bilateral posterior chest expansion exercise.
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398 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 22-15
FIGURE 22-16
Unilateral (segmental) breathing, left field. the left lower
shoulder must remain down,
with hands on ulnar border or palm up in his lap.
FIGURE 22-17
The either hand on the side of the
chest to be by his hand up.
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22 Facilitating Ventilation Patterns and Breathing Strategies 399
After each expiratory cycle, add more pressure until the chest wall to the lower sternum and touches the
the patient subconsciously increases the lower chest patient with the instructions again to "now breathe
breathing out of necessity. here." Finally, the therapist uses the first hand to
When you note more diaphragmatic and/or lower move up to the upper sternum (usually around the
intercostal muscle excursion, verbally note this to the level of the sternal angle) and asks the patient to
patient. Ask the patient to try to reproduce this pat "now breathe here." It is impol1ant that the therapist
tern. With your other arm continue to facilitate the smoothly transitions from one hand to the next to as
desired response, such as with the diaphragm scoop. sist the patient in developing a smooth motor transi
Slowly, during each of the next series of inhalation, tion from one area of the chest to the other. The man
release your inhibition as the patient tries to maintain ual cues provide tactile cuing rather than true motor
the improved lower chest breathing pattern. If the pa facilitation. Because of this, the normal timing se
tient is only partially successful, the inhibition can be quence is obviously a more-advanced technique in
partially reapplied to assist the patient. If the patient tended for use after achieving initial diaphragmatic
becomes anxious because the therapist's inhibition is training success.
preventing upper chest breathing, then decrease the
inhibition to a comfortable level. This technique
MOBILIZING THE THORAX
should never cause an increase in anxiety or it will
only encourage more upper chest breathing rather For some patients, controlled breathing alone may
than less. not alleviate the inefficient ventilatory patterns even
with utilization of good positioning and appropriate
ventilatory strategies. The thorax itself may be inca
Normal Timing
pable of moving freely enough to allow for adequate
During normal quiet inspiration (controlled breath chest wall excursion necessary for that breathing pat
ing), the diaphragm contracts, which is seen out tern. For example, a patient with a spinal cord inj ury
wardly as a gentle rise of the abdomen. The second who is demonstrating an excessive diaphragmatic
movement is seen as lateral costal expansion of the pattern that is unbalanced by the normal neuromuscu
lower chest and usually to a lesser extent, lower ante lar support of the intercostal and abdominal muscles
rior chest expansion. Lastly, the upper chest rises can breathe using minimal chest wall expansion. This
slightly in primarily a superior-anterior plane with is often noted as belly breathing. It may be necessary
less lateral expansion noted. A normal timing tech to mobilize individual rib segments to gain the poten
nique adapted from the physical therapy approach of tial for chest walJ expansion in aIL three planes of
proprioceptive neuromuscular facilitation (PNF) can ventilation before facilitating a specific breathing pat
help the patient work on this sequence. After the pa tern. If the potential for movement is not there, then
tient has learned to initiate inspiration with his or her the breathing pattern cannot change. Likewise, a pa
diaphragm and lower chest wall muscles more con tient with primary pulmonary dysfunction undergoing
sistently, this technique can help to put the whole se chest surgery, or a patient suffering from an acute
quence together. The diaphragm continues to be the chest trauma, may also find the rib cage stiff or sore
primary mover, but the other accessory muscles are and thus limited in its potential expansion. All three
encouraged to do what they should do, which is to as of these patients may benefit from the inclusion of rib
sist the diaphragm for better overall ventilation. cage mobilization in their therapy programs. The rib
Generally, the patient is positioned symmetrically cage musculoskeletal limitation may be secondary to
in either supine or supported sitting with a neutral muscular atrophy, spasticity, or pain. Thus patients
pelvic position. The therapist waits until the end of an with either primary pulmonary dysfunction or sec
expiratory cycle and then, using the hand placement ondary pulmonary dysfunction can benefit from the
of the diaphragm scoop, asks the patient to breathe in concept of chest mobilization.
"here." With the other hand, the therapist moves up It is beyond the scope of this textbook to detail all
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400 PART III Cardiopulmonary Physical Therapy Interventions
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22 Facilitating Ventilation Patterns and Breathing Strategies 401
• Postural inhibition
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402 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 22-18
Hand placement for facilitation of the pectoralis muscles for upper chest breathing.
Trapezius Facilitation
should be strong and demanding to elicit a stronger
maximal voluntary effort. The trapezius muscle assists in superior expansion
of the chest. Facilitation can be initiated in supine
or sidelying positions to decrease the resistance
Sternocleidomastoid and Scalene Facilitation
from gravity. It can be progressed to an upright
This same plinciple can be applied to the sternoclei posture in which the patient would have to work
domastoid and scalene muscles. In supine, therapists against gravity.
need only change the angle of their hand alignment to Placing the hands over the tops of the patient's
more specifically facilitate the sternocleidomastoid shoulders, the therapist quick stretches the trapezius
and scalene muscles. Turning the hands parallel to in a downward direction to facilitate a stronger eleva
the trunk so that the fingers are pointing up toward tion response. Repeated contractions e<in be added to
the neck rather than pointing out toward the shoulder, facilitate the contraction throughout the full ROM.
the therapist applies the same quick stretch and uses Obviously, the shoulder shrug motion should be
the same verbal cues. The altered hand position now paired with inhalation and upward eye gaze to maxi
specifically facilitates the sternocleidomastoid and mize the facilitation response.
scalene muscles and secondarily influences the pec
toralis muscles. The sternocleidomastoid and scalene
Inhibition of the Diaphragm
muscles primarily expand the chest in a superior and
anterior plane, whereas the pectoralis muscles expand Two techniques are described to inhibit the excessive
the chest in primarily a lateral and anterior plane, use of the diaphragm during inspiration. Ideally, the
thus accounting for the slight difference in the facili therapist is venturing to balance the use of accessory
tation positioning. muscles, especially the intercostal, sternocleidomas
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22 Facilitating Ventilation Patterns and Breathing Strategies 403
toid, scalenes, and trapezius muscles with the di To perform the diaphragm-inhibiting technique,
aphragm's contraction. This is done to prevent para the patient is positioned supine, semi-sitting or side
doxical movements of the chcst, or worse, to prevent lying with the top arm positioned overhead or pulled
adverse musculoskeletal changes in the chest wall, back at the waist to open up the upper chest. If toler
such as a pectus excuvatum that can result from mus ated, remove pillows from under his or her head, an
cle imbalance. teriorly tilt the pelvis and assess patient's airway
Inhibiting the diaphragm may be necessary during safety by checking if he or she can still swallow
breathing retraining for somc patients with spinal comfortably. The heel of the therapis t's hand is
cord injuries, polio, spina bifida, developmental de placed lightly on the patient's abdomen at about the
lays, head traumas, and cerebral palsy. The di level of the umbilicus. No instructions are given to
aphragm may be too weak to produce an adequate the patient at this point. As the patient begins to ex
tidal volume or vital capacity without the assistance hale a normal breath of air, the therapist gently al
of accessory muscles. In these cases the diaphragm lows the heel of his or her hand to move up and in to
inhibiting technique is used to encourage the use of ward the central tendon of the patient's diaphragm
the accessory muscles to assist in independent volun (see Figure 22-4, p. 394). When expiration for that
tary ventilation. Patients learn to use their weakened breath is completed, the therapist strictly maintains
diaphragm muscles in concert with intact accessory the hand position in that shortened expiratory posi
muscles. Not only does this allow for an increased tion. During the following inspiratory phase, the di
tidal volume and vital capacity, but it also provides aphragm will experience some gentle resistance to its
better aeration of all lung segments and better mobi inferior descent, causing inhibition to its full ROM.
lization of the entire thorax. On the next expiration, the technique is repeated with
In contrast to the first reason that this technique the therapist carefully pushing the heel of his or her
may be used, an unusually strong diaphragm, acting hand further up and in, maintaining greater inhibition
without support from surrounding m u sculature, during each inspiratory phase. After two or three
specifically the intercostals and abdominal muscles, ventilatory cycles, a patient usually begins to subcon
may also need to be inhibited. For example, a para sciously alter his or her breathing pattern to include
plegic or lower level tetraplegic patient with an intact more upper chest expansion to reconcile the di
diaphragm but absent abdominal and intercostal mus aphragm's transient inability to produce enough
cles may demonstrate a paradoxical breathing pattern chest expansion to yield an adequate tidal volume.
(see compensatory breathing patterns, Chapter 37). In The therapist should carefully observe which acces
this case the accessory muscles must be encouraged sory muscles the patient spontaneously chooses. Are
to keep the diaphragm in check, attempting to avoid they used symmetrically? What is the general quality
the development of a pectus excuvatum. The goal of of the movement? Is the onset harsh or smooth? Does
this breathing retraining method is to stop the para the patient appear fatigued or uncoordinated?
doxical movements of the upper chest during inspira It is not until this point that the therapist should
tion by balancing the use of the upper and lower verbally acknowledge any alteration of the patient's
chest. In some cases, spastic intercostal muscles, like breathing pattern. Without changing his or her hand
in some spinal cord injury situations, may intercede position, the therapist tells the patient what it is that
to prevent this paradoxical movement by maintaining he or she likes about the new breathing pattern (e.g.,
the upper chest's position during inspiration in spite balance between upper and lower chest expansion or
of the negative pressure within the chest and grav less paradoxical motion of the sternum). Then the pa
ity's influence on top of the chest. Balancing the tient is asked if he or she notices any difference from
chest's movements should produce an increase in before, bringing this breathing pattern to a consciolls
tidal volume and vital capacity potential and mobilize level. Only after some orientation to this pattern, usu
a greater portion of the chcst, just as the technique ally no morc than 4 to 6 breathing cycles in the full
does in the first case presented. inhibiting pattern, should the therapist begin to grad
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404 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 22-1 9
Diaphragm inhibiting in prone on elbows position.
ually release the pressure being applied. already been achieved. Extra care must be taken not to
While slowly releasing pressure with each cycle of initiate any applied pressure quickly because of the
inspiration, the therapist asks the patient to attempt likelihood of eliciting unwanted abdominal contrac
cognitively to reproduce the desired pattern. It should tions or spasticity or eliciting a stronger diaphragmatic
take the same number of cycles to release the pres contraction resulting from the quick stretch reflex. The
sure as it did to apply it. This technique easily allows technique should never be painful. The therapist must
fo r gradations of i n h ibition, from full inhibition, keep his or her hand on the abdomen, not the rib cage,
where the patient is forced to use upper accessory to properly influence the diaphragm. This technique
muscles or risk becoming short of breath, to barely a can be progressed by c hanging postures, which re
proprioceptive reminder to change his or her breath quires greater tl1lnk control. Can the patient still main
ing pattern. It also allows for gradation of inhibition tain the overall pattern? Can the patient breathe with
while the patient is learning to assume control over out paradoxical movements against gravity?
the new breathing pattern. If during the releasing The second technique is for the more advanced pa
phasc of this technique the patient begins to lose con tient and simply presents a physical block to diaphrag
trol over the new pattern, the therapist can gently matic excursion. The patient is positioned in a prone-on
reapply some pressure during the next expiratory elbows position (Figure 22-19). With most severely
phase to help the patient regain that control. At that neurologically impaired patients, the lower chest will be
point, the therapist can release or reapply pressure as in direct contact with the surface, so lower anterior and
neccssary until the desired pattern is obtained and full inferior expansion is inhibited and lateral costal expan
release of pressure is completed. sion is limited. The upper chest is positioned in exten
This technique is particularly effective with patients sion and the upper extremities are fixated, optimizing the
who are having difficulty cognitively altering their length-tension relationsh.ip of the anterior and superior
own breathing pattern, such as with small children, accessory muscles for easy facilitation. In addition, ante
brain-damaged patients, or slow motor learners, be rior excursion of the upper chest is now in a gravity-as
cause it requires no cognitive effort until success has sisted posture. Through the use of head and neck pat
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22 Facilitating Ventilation Patterns and Breathing Strategies 405
FIGURE 22-20
Static-dynamic upper extremity activities in prone on elbows to encourage upper chest accessory
muscle participalion.
terns, such as in PNF diagonals, or static-dynamic activi now assisting anterior excursion of the chest and re
ties, such as in weight shifting to one supp0!1ing limb sisting posterior excursion. To emphasize the serratus
while reaching out with the other extremity, the therapist anterior muscle's role in posterior expansion, the pa
can readily facilitate greater upper chest breathing (Fig tient is instructed to perform an upper body push-up
ure 22-20). These are the same patterns the therapist can (with or without the therapist's assistance). The serra
use to achieve other goals, such as increased head and tus anterior muscle causes lateral scapular movement
neck control, increased shoulder stability, or increased thereby facilitating maximal posterior excursion of
upper body balance. Therefore, by helping the patients the thorax. The patient is instructed to take a deep
to coordinate movement goals with ventilatory patterns, breath in during the push-up and to exhale the air
it becomes more likely that the patients will incorporate (passively or forcefully) when returning to the start
these patterns functionally into daily activities. This is ing position. Forceful exhalation in this activity can
the ultimate goal of any ventilatol)' retraining procedure. be used as a forerunner to effective cough retraining.
The manual diaphragm-inhibiting technique is Gentle or controlled exhalation can be used to en
usually less threatening to the patient than the prone courage greater breath support for vocalization or f6r
on-elbows-inhibition technique. Prone on elbows it eccentric trunk muscle training.
self can inhibit the diaphragm so completely for neu Emphasizing posterior chest expansion during in
rological patients lacking spinal extensors that they halation is the only occasion where inspiration would
become extremely short of breath. Consequently, do be paired with trunk flexion. In all other inspiratory
not position the patients in this more demanding pos situations, inspiration is paired with trunk extension,
ture until success appears likely. and exhalation is paired with trunk flexion.
Facilitating greater posterior chest expansion can be Patients with asymmetrical weakness need a different
achieved in a prone-on-elbows position. Gravity is approach from the controlled or upper chest breathing
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406 PART III Cardiopulmonary Physical Therapy Interventions
Symmetrical ventilatory patterns may be effortlessly Another technique to promote symmetrical chest wall
achieved by altering the patient's position in each movements is performed in numerous postures, such
posture to maximize the chest wall's potential to as supine, sitting, or standing. The therapist places his
move in a symmetrical pattern. This is especially true or her hand symmetrically on the lower lateral chest
in an upright position in which asymmetry is gener wall, on the mid chest, or on the upper anterior chest
ally more pronounced. For example, hemiplegic pa wall. At the end of exhalation, the therapist gives a
tients may lean toward their involved side in sitting quick stretch on the muscles being touched to facili
because of weakness or spasticity. Likewise, after tate a deep inspiratory effort in that area of the chest.
thoracic surgery, a primary pulmonary patient may Immediately after both sides begin to move into an
lean toward the surgical side to avoid pain caused by inspiratory pattern, the therapist manually blocks (or
chest movement around the incision. Both situations inhibits) expansion of the chest on the stronger side
cause asymmetrical breathing patterns and decrease while giving continued quick stretches on the weaker
ventilation on the involved side. Improving chest side. This facilitates greater expansion on the weak
wall alignment may alleviate the ventilatory deficit side by use of an overflow response. This technique,
on the involved side. adapted from the PNFs timing for emphasis tech
nique, uses the strength of the stronger side to facili
tate movement on the 'Yeaker side. It can be applied
Postural Inhibition
to any area of the chest where symmetrical move
For some patients, more aggressive positioning must ments should be the norm.
be used to achieve greater chest wall excursion and
ventilation on the involved side. This can be accom
REDUCING RESPIRATORY RATES
plished by inhibiting the chest wall movements on
the uninvolved or stronger side. Usually, the best In addition to altering breathing patterns through fa
posture in which to achieve this inhibition is sidely cilitation and inhibition techniques, reducing respira
ing. When the patient lies on his or her uninvolved tory rates (RR) may also be necessary before arriving
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22 Facilitating Ventilation Pattems and Breathing Strategies 407
at an efficient breathing pattern for some patients. sisted cough technique. One medical contraindication
See the box below for a summary of techniques. for this technique is bony instability of the spine be
Many neurological patients with high neuromuscular cause of its rotary nature.
tone increase their RR to compensate for a decrease In bed or on a mat, place the patient in sidelying
in their tidal volumes (TV) or because of brain-stem with knees bent and arms resting comfortably out in
impairments to the respiratory centers. In addition, front of the head or shoulders. In this technique the
many patients who are anxious, such as asthmatic, or higher the upper extremities can be placed within a
thopedic, or surgical patients experiencing pain, may comfort zone, the better the result. Relaxed position
also demonstrate an excessively high RR. Attempting ing of the patient is essential to the success of this
to restore ventilatory efficiency may require increas technique, thus position the patient in an open yet
ing TV while concurrently decreasing RR. comfortable position. Normalizing neuromuscular
tone is the first step in attempting to decrease a high
RR. Patient discomfort is likely to elicit increased
Previous Facilitation Techniques
tone and an increased RR.
The techniques previously described in this chapter The therapist's own position is also important be
promote an increase in TV by improving the overall cause it directs the force that is applied to the pa
ventilatory patterns and often cause a secondary reduc tient's chest. Initially, the therapist needs to stand
tion in RR. See sections on controlled breathing, mobi behind the patient, perpendicular to his or her trunk.
lizing the thorax, and upper chest breathing facilitation. If the patient is lying on the left side, the therapist
places his or her left hand on the patient's shoulder
and his or her right hand on the patient's hip. The
Counterrotation
therapist then leaves his or her hands in place and
The technique described next is specifically devel simply follows the patient's respiratory cycle. This
oped to promote a lower RR. The counterrotation allows the therapist to assess the patient's subjective
technique reduces high neuromuscular tone and in rate and rhythm and the patient's overall neuromus
creases thoracic mobility, thus often resulting in an cular tone. Only after this assessment should the
increase in TV and simultaneous reduction in RR. clinician begin the active phase of the technique.
These authors have found this technique to be ex Using a PNF technique called rhythmic initiation,
tremely effective for the following: (I) patients with the patient is gently log-rolled in a small ROM in
decreased cognitive functioning after a neurological sidelying. The rolling is gradually increased achiev
insult or after surgery, (2) very young children be ing more ROM from sidelying toward prone. This
cause there are no verbal cues, or (3) patients with progression of movement generally reduces high
high neuromuscular tone. As described in Chapter 21, tone, which usually makes the second phase of the
it can also be easily adapted as a very effective as- technique more effective.
During this phase, the therapist needs to audibly
duplicate the patient's RR. As the patient moves into
greater rolling ROM and begins to slow his or her
Techniques to Reduce High Respiratory Rates RR, the therapist needs to use the patient's audible
cuing as a facilitator for establishing a slower RR.
I. Previous techniques that increased tidal volume
Thus the therapist begins by having the patient estab
2. Countenotation technique
lish the audible RR and then the therapist slowly
3. Butterfly technique in sitting
takes over. Audible cues can be very strong facilita
• Straight planes tors of ventilatory rhythms.
• Countenotation Phase two requires the therapist to slowly change
4. Relaxed pursed lip breathing with inspiratory his or her position. Transitioning to a diagonal pos
and expiratory pauses ture, the therapist now stands or half kneels behind
the patient near his or her hips, turning diagonal to
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408 PART III Cardiopulmonary Physical Therapy Interventions
the patient until the patient's head at roughly removed should be the audible cues. As with the di-
at angle, The hand placement to get biting tech the therapist can
more Assume that the patient is side- reestablish control quickly if needed by simply reap
lying on the left At the of the plying stronger manual input. If the has an ex-
cycle, the left hand fast RR 50 to 60 breaths/min), the facili
patient's shoulder on the tation can be every 2 to 3 breaths so as not to
care being taken not to unintentionally use the thumb the patient or
or tips, and the hand back It should be apparent that this technique need not
to the patient's right fossa (the hollow of the be used for goals but rather
21-6, A, The can can be total rehabilita
then compress the rib cage in all three tion program. It is a natural precursor to active rolling
planes of ventilation at the end of exhalation by gen or it can be used as a vestibular stimulator.
tly pulling the shoulder back and down, while simul
pushing the hip up and forward, This
Butterfly Technique
movement promotes more complete exhalation,
When the patient the next inspiration, the If the has greater motor control, an
therapist switches hand to capitalize on the version of this technique may be appropriate. In un
improved for TV, The therapist's left hand supported stand behind or in front of the pa-
slides back to the patient's and the ther depending on his or her balance and ask
hand slides forward just anterior to the to bring his or her arms up into a butter
right iliac crest Figure 21 B, p, 376). or assist his or her arms up to this pos
As the patient inhales, the therapist slowly stretches from a comfortable ROM position for
the chest to maximize volumes (TVs). that patient, to audibly breathe with the pa
The left hand the scapula (or the tient's RR. When the patient raise the arms
thorax if the is unstable) up and away from up into slightly more shoulder flexion. When the pa
the spine and the hand the back and tient lower the arms slightly.
down to maximize all three planes of re to move in greater and greater increments of range,
in greater inspiration. The therapist should use all the while out loud with your
the flat or heel of the hand whenever possible to Through your audible breathing cues, to "ask"
avoid unintentional patient discomfort and to maxi your patient to slow down the RR and take deeper
mize the facilitated area. slower breaths. The use of the followi ng
Initially, the begins and ends the deeper inhalations
cycle according to the patient's RR. as and exhalations: ( l ) shoulder flexion and trunk ex
tone is relaxed and increased TVs are tension with inspiration and (2) shoulder ex
through the effects of counterrotation, the tension and trunk flexion paired with exhalation.
therapist slows the rate of rotation down, Thus it becomes and for the pa
the audible breathing cues to also facil tient to increase his or her TV and decrease RR.
itate a slower RR. The patient accommo As in the previous technique, the therapist
dates to a slower RR as the therapist more con by out loud at the pace and transi
trol over the patient's pattern. With many audibly at a more desirable
the results can be marked. If the patient can pace, The picks up on this subtle cuing and
cognitively follow commands, he or s h e can be subconsciously reduces his or her own RR even if
alerted to this and to assist in vol cannot follow verbal commands.
untarily at the slower rate. This technique can be modified to encourage more
The therapist can progress the by de- intercostal and oblique abdominal muscle contrac
the manual input. The last facilitation to be tions by using a diagonal rather than a straight
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22 Facilitating Ventilation Patterns and Breathing Strategies 409
A B
FIGURE 22-21
C, butterfly with twnk rotation facilitating inspiration. All threc planes of respiration are stretched
on the patients right side. D, butterfly with twnk rotation facilitating exhaltation. All planes
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410 PART III Cardiopulmonary Physical Therapy Interventions
of movement. Have the look up and over one and proceeds to force the air back and down the
shoulder as he or she breathes in and brings arms up throat with a maneuver of the tongue,
and behind his or her head. Then have the ynx, and larynx.
look down and away toward the opposite knee as he Research has consistently shown that use of this
or she breathes out and brings arms down to the op with severely pa
knee (Fieure 22-21). tients can increase pulmonary functions signifi
especially for TV and Vc. If GPB is the only
means of ventilation off of a ventilator or
Relaxed Pursed-lip Breathing
nerve stimulator, mastery of this technique is critical
Use of a relaxed to a survival in case of mechanical failure.
ously described under All should be made to successfullv teach
breathing pattern," is also a technique to reduce RR. GPB to this patient population.
By the expiratory through pursed A clinical example may to illustrate its use
the patient secondarily decreases his or her RR. fulness. A l4-year-old male sustained a C 1 \"VllllJlilA\V
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22 Facilitating Ventilation Patterns and Breathing Strategies 411
sessions can be lengthened considerably, and the pa demonstrates to the patient what a stroking maneuver
tient can be taught self-monitoring techniques. Specific looks like several times to give an idea of the motion
goals of GPB training must be explained to the patient required. The therapist continues to mimic the pattern
before the beginning of treatment to gain his or her as the patient attempts to duplicate it. This gives the
support and cooperation. In addition to providing the patient an active model to mimic and decreases feel
ventilator-or stimulator-dependent patient with a TV ings of uneasiness surrounding the necessary but
necessary for gaining independence from mechanical somewhat silly facial grimaces. If the patient is able
assists, GPB has many other b e n e f i t s. F o r the to breathe independently, his or her ability to breath
tetraplegic patient who has a partially intact diaphragm hold and to close off the nasal passageway should be
(C3 to C4) or the loss of essential accessory muscles checked because air leakage is a common cause of
(C5 to C8), GPB can accomplish the following: (1) in failure. The patient is then instructed to take in a
crease VC to produce a more effective cough, (2) as maximal inspiration before attempting the stroking
sist in a longer and stronger phonation effort, and maneuvers to eliminate the possibility of using other
(3) act as an internal mobilizer of the chest wall. accessory muscles during the technique.
The muscles used in this technique do not have the If possible, position the patient in an upright or at
same internal proprioceptive, sensory, or visual feed least a symmetrical position. Specifically, the patients
back mechanisms as the trunk and limb muscles. Thus are instructed to bring their jaws down and then for
necessary adjustments in the technique are sometimes ward as if reaching their bottom lip up for a carrot
difficult to see or feel. The patient cannot see his or dangling just in front and above the upper lip (Figure
her tongue pushing the air back or truly feel the phar 22-22, A). Slight cervical hyperextension is necessary
ynx swallowing the air into the lungs, so the thera to allow for maximal temporal mandibular joint
pist's external feedback system is very influential. (TMJ) excursion. (A contraindication for this tech
Use of a minor can greatly enhance the visual compo nique is a TMJ disorder.) The lips should be shaped
nent of feedback. Small changes, like adjustments in as if they were to make the sound "oop." The patient
posture or a suggestion of another sound to imitate, is then told to close the mouth, reaching the bottom
may be all that is needed for the patient to learn tbe lip up to the top lip (see Figure 22-22, B). The tongue
stroking maneuver correctly. Success in GPB can be and jaw are drawn back toward the throat, with the
assessed objectively with a spirometer and a pulse mouth and tongue formation of the word up or the
oximeter. For those patients incapable of breathing in sound "ell" (see Figure 22-22, B). The lower jaw is
dependently, any TV reading will indicate successful moving in roughly a rectangular pattern. Most pa
intake of air. For patients who are not ventilator de tients learn the stroking maneuvers by making the
pendent, a VC reading that is greater than 5% over the sounds at first, as they become more proficient, the
baseline indicates successful use of GPB. Lower-level sounds and excessive head and neck motions dimin
tetraplegics, C5 to C8, have demonstrated increases in ish. Often, the students (patients) outperform the
VC by as much as 70% to 100%. teacher (therapist), because through consistent use,
Therapists can monitor their own successes with they learn all of its finer subtleties.
this technique by taking VC readings with and with Although this technique can be broken down into
out GPB or by subjective analyses. Maximal inhala several stages as it has been here for the purpose of de
tion, followed by three or four successful GPB scription, most of the literature cautions the therapist
strokes, will cause a feeling that the chest will burst if against it. (Zumwalt, Adkins, Dail, and Affeldt, 1956).
an attempt is made to inhale more air. Likewise, a Simple, minimal insuuctions seem to accomplish more,
sensation of "needing to cough" is another subjective perhaps because the continuity of movement is so es
indication of successful GPB. However, a feeling of sential to the success of the inhalation. Specific instruc
indigestion is usually indicative of swallowed air in tions can be given later if necessary.
the stomach instead of the lungs. Common problems encountered with GPB instruc
During the initial treatment session, the therapist tion are as follows: (I) an open nasal passage or glot
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412 PART III Cardiopulmonary Physical Therapy Interventions
A B c o
FIGURE 22-22
Glossopharyngeal breathing; A, mouth opened to draw in air; B, j aw closed to entrap the air; C, air
pushed back with tongue into trachea; D, vocal folds closed to prevent passive air leaks. Entire
maneuver is then repeated.
tis that allows the air to escape, (2) a feeling of indi els begin to fall to the mid 90s and then the low 90s,
gestion indicating that the air is being swallowed into you can anticipate when they will reach 90%. At that
the esophagus rather than the trachea, (3) incorrect point, end the GPB training and put the patient back
shape of the mouth as the air is bein g drawn in, usu on the previous ventilatory support system. Oximetery
ally not puckered enough, (4) uncoordinated back not only allows for accurate monitoring but also pro
ward movement of the tongue, (5) inadequate jaw vides a means for an objective means for monitoring
mobility, TMJ dysfunction, or decreased cervical progress over time. In addition, a spirometer objec
ROM, or (6) incorrect sounds while performing the tively measures improvements in VC using GPB. It
technique, such as the word gulp or an "em" sound. gives the patients concrete indications of success or
A voiding any instruction for the tongue seems to pro failure with the technique.
duce better results. Concentrate on assisting the pa
tient in learning the external physical movements.
ENHANCING VOCALIZATION SKILLS
Tolerance to GPB can be increased when mastery
of a single stroke becomes consistent. For patients In contrast to procedures that assist the patient in in
using it as an assist to their own voluntary ventilation, halation, procedures intended to improve a patient's
3 to 4 strokes on top of a maximal inspiration is usu phonation skill must focus on elongating the expira
ally sufficient. Ventilator- or stimulator-dependent pa tion phase. Coughing is a gross-motor skill that relies
tients may need to use as many as 10 to 14 strokes per more on force than fine control of the ventilatory
breath. These figures should be used only as rough muscles for its effectiveness. Conversely, phonation
guidelines. Each patient will use a slightly different requires precise, fine-motor control of these muscles
technique with a different number of strokes, with the and the vocal folds to provide a consistent air flow
only important factor being a method that works for through the larynx. Both are expiration activities and
them. Fatigue with long trials of GPB can be moni depend on the preceding inspiration for optimal per
tored effectively with an oximeter. The oxygen satura formance; however, coughing uses concentric con
tion level should stay above 90% to maintain adequate tractions of the expiratory muscles to force the air
Pa02 levels. For example, if the patient begins the out, and quiet talking uses primarily eccentric con
GPB session with an oxygen saturation level in the tractions of the inspiratory muscles to slowly release
upper 90s, fatigue can be monitored and anticipated the air during expiration. Because of these differ
by watching if the oxygen levels decrease. If the lev ences, procedures to improve coughing and phona
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22 Facilitating Ventilation Patterns and Breathing Strategies 413
• Vibration or shaking
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414 PART III Cardiopulmonary Physical Therapy Interventions
enjoy the new sound that this makes and will try repeat the arm's descent. The activity can be progressed sev
edly to phonate longer and louder to accentuate the dif eral ways. The activity can include lifting something
ferent intensities. heavy off the shelf and controlling it along with the
Therapeutically, this requires them to take a arm and trunk while lowering the object or weight to a
deeper inhalation before vocalizing, followed by an table or to the patient's lap. Or the postural demands
elongated expiratory phase, both of which are neces of the activity can be increased. The patient can still
sary for functional speech. As the child becomes lift the heavy object or weight but he or she can now
more adept at it, the therapist can apply more pro be required to do this in standing, which increases the
nounced clapping over the chest, accomplishing a demands on the musculoskeletal system.
wider range of voice intensities and doubling as a
means of percussion for postural drainage.
Verbal Techniques
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22 Facilitating Ventilation Patterns and Breathing Strategies 415
advanced and should be used only after some control more desirable. Some may benefit even more from
of exhalation has been mastered. techniques to reduce the high RR or to mobilize the
thorax. For a select patient population, instruction
in GPB may be necessary to support breathing off
SUMMARY
of mechanical ventilatory support. Lastly, the ther
In summary, use of appropriate choices in positioning apist can now choose to use techniques to improve
together with use of an appropriate ventilatory and the patient in developing adequate breath support
movement strategy for any given task will make the for vocalization and communication.
success of that task all the more likely. If these sim It is these authors' hope that the therapist now un
ple, time-efficient methods of facilitation do not pro derstands how widespread the influence of effective
duce adequate ventilatory changes by themselves, it ventilation can be on a patient's recovery from dis
is then appropriate to add on the next layer of facilita ease or trauma. Understanding that facilitating effec
tion-manual facilitation techniques. Specifically, tive ventilation goes far beyond the old diaphrag
the techniques that are described in this chapter assist matic exercises, therapists can be empowered to
in facilitating the following: (1) greater diaphrag incorporate other techniques and strategies to get
matic breathing patterns (or controlled breathing), their patients healthier quicker and to assist them in
(2) increased chest wall mobility, (3) greater acces reaching their greatest rehabilitation potential.
sory muscle breathing patterns (or primarily upper
chest breathing), (4) increased symmetrical breathing
patterns (unilateral disorders), (5) reduction in high REVIEW QUESTIONS
respiratory rates, (6) auxillary techniques GBP, and 1. Why would a therapist want to try to change a
(7) improved phonation support. Obviously, not all patient's breathing pattern?
techniques would be appropriate for any single pa 2. How can ventilatory strategies be incorporated
tient. It is up to the therapist to determine which tech into a treatment session?
niques would best address their patients' deficits. 3. When would a therapist not teach diaphragmatic
In conclusion, positioning has everything to do breathing?
with increasing ventilation potential and functional 4. What is the role of relaxation in breathing control?
skills. From the beginning of the patient's respira 5. When would a therapist consider teaching the pa
tory program, optimizing ventilation and breath tient to use his upper chest more in breathing?
control through passive and active positioning 6. When would a unilateral breathing pattern be
techniques should be used by all medical disci taught?
plines, not just physical therapy. As the patients
progress, the clinician can and should, assist them
in developing better and more efficient movement
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Copyrighted Material
416 PART III Cardiopulmonary Physical Therapy Interventions
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Copyrighted Material
Exercise Testing and Training:
Susan K. Ludwick
INTRODUCTION
Shortness of breath, especially with activity, is very and then be able to devise therapy programs that
common in patients who have cardiopulmonary dis would keep these individuals active within the limits
eases. Shortness of breath can be quick in onset or of their disease in order for them to maintain certain
of a chronic nature. One of the results of shortness levels of independence.
of breath, especially when it is of a chronic nature,
is the vicious cycle of deconditioning it causes in
LUNG DISEASE
patients. Eventually, these individuals may become
deconditioned to the point that activities of daily liv In individuals without lung disease the cardiovascular
ing usually taken for granted, such as washing up in system normally limits maximal aerobic exercise.
the morning, may be overwhelmingly fatiguing. Typically, maximal oxygen consumption (Vo2) may
Physical therapists need to understand the underly be limited by the heart's inability to increase its cari.i
ing mechanisms of shortness of breath, evaluate diac output (Q) either by an inability to increase heart
their patients appropriately given their limitations, rate (HR) or stroke volume (SV) or by an inability to
417
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418 PART III Cardiopulmonary Physical Therapy Interventions
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23 Exercise Testing and Training: Primary Cardiopulmonary Dysfunction 419
rest and with exercise. Specifically, longer expiratory consumption during exercise above which a sus
cycles are observed because of the extra effort these tained lactic acidosis occurs, is useful in measuring
patients make to empty their lungs before inspiration. exercise tolerance in normals. However, it is not par
Patients with restrictive lung disease have a pattern of ticularly useful with patients, since peak exercise
rapid, shallow breathing in an effort to maintain ade levels may be below the anaerobic threshold. Some
quate minute ventilation in the face of decreased lung have looked at the measurements of FEV [ and FVC
capacities. to predict exercise capacity. However, the literature
has shown that there is no correlation between these
measurements of lung mechanics and exercise ca
HEART DISEASE
pacity. It makes more sense to define exercise capac
Patients with acute or chronic cardiac failure or ity by evaluating the patient's functional exercise ca
valvular heart disease have elevated pulmonary ve pacity. This can be done by using timed walking
nous pressures. This develops into intersti tial distances. The 12-minute walk as defined by Ken
edema. Therefore the lungs are said to be "wet," neth Cooper has been adapted by McGavin, Gupta,
their compliance is decreased, and the work of and McHardy (1976) for use with patients that have
breathing is elevated. chronic bronchitis. This test is also useful in deter
Clinically, these patients have pulmonary rales on mining exercise capacity in other patient populations
auscultation. They adopt rapid, shallow breathing as well. This evaluation is useful because it corre
patterns to minimize respiratory muscle work. These lates with V02 as measured on the treadmill. How
patients, as with patients with chronic lung disease, ever, results are reported in terms of distance walked
will have ventilatory responses to exercise, depend and not in how much oxygen was consumed. There
ing on the severity of the disease. fore it gives a more functional picture of exercise
tolerance since it uses a familiar activity. If 12 min
utes is too long for some patients, 3- and 6-minute
Assessment
walks are just as useful. These walking tests are sim
Before starting the actual exercise assessment, it is ple to implement and use simple measurement de
important to get an idea of the patient's activity level vices. Patients can also use them as methods to mon
and what activities cause shortness of breath. How itor their own progress.
far can the patient walk before becoming short of To assess patients using the 12-minute walk, one
breath? Can the patient tolerate walking outside? Is must simply instruct the patient to walk as far as pos
he or she only able to walk comfortably to get about sible in 12 minutes. It is not absolutely necessary to
inside a house or apartment? Can the patient walk up walk without stopping. The patient may slow down
stairs? Does dressing, taking a bath or shower, or or even stop to take a short rest if needed. The only
combing hair cause shortness of breath? Can the pa required equipment is a stopwatch and a measured
tient do his or her own grocery shopping? Is the pa corridor.
tient able to do any heavy housework, such as vacu
uming or bed making? Is the patient able to make his
UPPER-EXTREMITY VERSUS lOWER-EXTREMITY
or her own meals?
ACTIVITY
If aerobic capacity is limited because of either
cardiac or ventilatory limitations, how can we func Up to this point, we have discussed exercise assess
tionally assess exercise capacity without the use of ments in reference to lower-extremity activity. How
expensive testing equipment? Traditional methods of ever, shortness of breath may be of even earlier onset
measuring maximal oxygen uptake, including tread when perfomling routine activities of daily living in
mill testing, may have limited usefulness because volving upper extremities (i.e., grooming, lifting, and
oxygen uptake for the pulmonary patient, as ex carrying). This in fact may be the most frustrating
plained before, is limited by ventilation. Anaerobic limitation to patients, since these are the types of ac
threshold, which is defined as the highest oxygen tivities that we normally take for granted in our
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420 PART III Cardiopulmonary Physical Therapy Interventions
everyday Ii ves. When patients begin to have diffi ing expiration. There are no compressive forces
culty performing these activities, they feel a loss of working to narrow the airways. However, in patients
control in their lives. It is important to note that the with airflow limitation, the work of breathing is
exercise responses to these activities are different and shifted to the muscles of expiration. Therefore expi
should be assessed separately from walking. ration becomes a more active process, resulting in the
CeJli, Rassulo, and Make (1986) have reported the generation of more positive pleural pressures com
appearance of dyssynchronous thoracoabdominal pressing the airways. Closing off of airways creates
movement when comparing arm activity with leg ac the feeling of shortness of breath. An impOItant yet
tivity. Early fatigue was observed to occur despite simple technique that can be taught to patients is the
lower heart rates, minute ventilation, and oxygen up practice of purse-lipped breathing to control short
take when compared with leg work. It was hypothe ness of breath. By having the patient expire through
sized that exercise limitation during arm activity was pursed lips, a back pressure is created in the airways
probably because of a smaller contribution of acces that helps to keep them from collapsing despite the
sory muscles to the work of breathing, since these positive pleural pressures down on them. This is a
muscles must contribute to postural support of the useful technique that can be used at rest and during
upper extremity during activity. Despite these limita exercise to slow down respiratory rate, increase tidal
tions in upper-extremity exercise tolerance, improve volume, and increase blood oxygenation.
ments have been demonstrated after an exercise train When evaluating exercise tolerance with patients,
ing program. it is impOItant to assess the work of breathing. Borg
Upper-extremity assessments may be considered (1982) has developed two scales that can help to
two ways. They can be either supported or unsup quantify dyspnea. In our facility, we have used a sim
ported (Criner and Celli, 1988). Supported assess ple scale of I to 4 to describe shortness of breath (see
ments would be those that may involve the use of an boxes below and on p. 421). On our scale, a score of I
upper-extremity ergometer. Unsupported assessments would represent baseline (comfortable) breathing. A
would include those activities involving reaching. score of 4 would represent shortness of breath so se
Since activities of daily living involve combing hair, vere that one is not able to talk. Since exercise limita
washing, dressing, and reaching at various heights, tion is more closely related to ventilatory rather than
assessments imitating these things would be most
useful. One such test that could be used would in
volve repetitive reaching at a height level to the head. The 15 Point RPE Scale
Reaching up with a light object of approximately I
6
pound may imitate reaching up to kitchen cupboards
7 VERY, VERY LIGHT
to put away groceries. Counting the number of repeti 8
tions and timing the activity would give a functional 9 VERY LIGHT
picture of upper-body activity tolerance. 10
II FAIRL Y LIGHT
12
BREATHING 13 SOMEWHAT HARD
14
Patients who have pulmonary diseases have limited 15 HARD
ventilatory reserves, which manifests as shortness of 16
17 VERY HARD
breath. The degree of the shortness of breath may de
18
pend on the severity of the lung disease. Normally,
19 VERY, VERY HARD
during quiet breathing, average pleural pressures sur 20
rounding the large airways are typically negative,
whereas intraluminal pressures are more positive. Borg, G. (1982). PsychologicaJ Bases of Perceived Exertion, Medi
These positive pressures keep the airways open dur cine and Science ill Spor/s and Exercise, 14,378.
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23 Exercise Testing and Training: Primary Cardiopulmonary Dysfunction 421
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422 PART III Cardiopulmonary Physical Interventions
Intensity
more commonly used because walking and running
Patients should exercise so that their breathing are more natural activities. A is more likely
how hard are working. We advocate that to reach his or her maximum oxygen consumption
work no higher than a level 3. After the cool-down and heart rate. However, ECG recordings tend to
breathing should be at baseline. have more artifact and blood pressure are
more difficult to obtain at high intensities. If tread
mill testing is the of choice, there are sev
Termination of Exercise Testing or Training
eral different protocols that use different
Several or symptoms will alert the therapist that combinations of elevation and belt The
the session should be This chapter focuses type of treadmill test used on the fitness
clinical situations not using electrocardio level of the patient and the reason for doing the test.
(ECG) or sophisticated monitoring systems. For example, certain protocols may be used
response must be watched to test initial aerobic fitness levels in
closely, such as facial appearance of in individuals and athletes and then for
creased use of accessory in addition, blood fects of their training programs. Another type of
pressure, heart rate, and pulse oximeter are treadmill test may be used to diagnose cardiac
very important. Exercise should be terminated in any disease. The two most used protocols are
of the following situations: the Bruce and Bakke exercise tests. They have nor
• Patient mative data from which functional aerobic
• Chest pain occurs or increases from patient's ment can be calculated.
normal
• Patient appears pale and skin is diaphoretic
Energy Conservation and Work Simplification
• Blood pressure is elevated or
with exercise
with energy conservation and work
• Patient complains of leg cramping fication techniques is an important component of
• Oxygen saturation drops below 90% cardiopulmonary An of the pa
• Patient complains of dizziness tient's work for modifica
• Patient's coordination is affected by increased tion with the goal of achieving increased functional
muscle weakness and with prolonged ex life needs to be stressed. A brief
ercise
rices to patients.
TRADITIDNAl TESTING
Since most individuals have been accustomed to a
For those without shortness of breath from faster oaced life. oacing is a basic conceot worth dis-
lung disease or cardiac failure who could tolerate
there are more traditional it is to
that are useful in assess- slow down when walking or climbing stairs. Patients
exercise The primary modalities used will not be as tired and out of breath when reaching
are bicycle ergometry and treadmill There their destinations. Rest periods should be planned
are and to both. ECG the If wasting time is a concern while
monitoring and blood pressure readings may be more taking a break, reading a book or doing some hand
easily obtained if a is tested on a work may make this time more worthwhile.
the to this modality is that a cart to carry items is quite helpful.
this is not as familiar an activity to some as activity while items in
walking. Therefore maximal heart rates may not be creases oxygen consumption when If oxy
achieved because of leg fatigue. Treadmill testing is gen consumption is increased, require
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23 Exercise Testing and Training: Primary Cardiopulmonary Dysfunction 423
ments also will be increased as described previously. 3. Explain the physiological benefits of exercise
Shortness of breath will increase. If a shopping cart is training with COPD and the perceived mecha
used, leaning on the cart to take a rest will help to nisms of improvement.
keep breathing under control. 4. Name the components of a pulmonary rehabilita
Sitting down to work is an energy saver because it tion program.
saves the legs the work of standing. Standing in the 5. Name and discuss techniques of energy conser
bathroom to shave or wash at the sink can be elimi vation.
nated by placing a chair in front of the sink or by sit
ting on the toilet-seat lid. Buying a shower chair
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programs will help these patients improve their func
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mon daily activities, Chest, 63, 126-127.
Thoman, R.L Stroker, G.L., & Ross. J.e. (1966f The efficacy of
REVIEW QUESTIONS pursed-lips breathing in patients with chronic obstructive pul
monary disease, American Review of Respiratory Disease, 93.
1. Name and explain four limiting factors of exer 100-106.
cise in the patient with COPD. Weber, K.T., & Szidon, J.P. (J 986) Exertional dyspnea. In Weber,
2. Explain traditional measures of exercise capac K.T., Janicki, J.S. (Eds.): Cardiopulmonary exercise testing.
Philadelphia: WB Saunders.
ity. Which ones are useful for measuring exer
cise capacity in COPD?
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Exercise Testing and Training:
Secondary Cardiopulmonary
Dysfunction
Phyllis G. Krug
425
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426 PART III Cardiopulmonary Physical Therapy Interventions
breath up to 10 years before seeking medical <lttention review presented here, notes arc included to encour
(Black, 1982). The patient usually attributes the symp age critical analysis of diagnostic material.
toms to aging and lack of exercise before considering
Pulmonary function tests
a medical reason. It has even been documented that
patients will curtail activities, social and recreational, Pulmonary functions tests (PFTs) are used to evaluate
before seeking medical advice. By the time medical flow rates and volume capacities of the lung. Detailed
attention is sought, a damaging cycle has been estab descriptions of these are presented in Chapter 8. Un
lished (Figure 24-1). The results of inactivity con derlying assumptions in these reports are that a patient
tribute to feelings of inadequacy and poor self image. (1) has cooperated with the testing procedure, (2) has
The inactivity itself fosters and encourages atrophy, understood the procedure and, (3) has normal respira
not only in the extremities where it is visibly apparent tory muscle strength to accomplish the test. Let's try
but also in the respiratory muscles. This fUlther adds and understand the factors that could blur optimal re
to the debilitating process, creating secondary weak sults when taking a pulmonary function test. If a result
ness and disabilities that are not necessary and are is produced that shows the patient has poor lung ca
avoidable. These issues are further addressed in the pacity, you could walk away thinking. "Wow, that's a
approach to treatment and in the case studies. really sick person there, most probably there isn't
much I can do to help because he is so restricted in
lung capacity." If you look further and investigate the
EVALUATION
possibilities, you begin to open windows or possibili
The evaluation begins before the patient arrives. It ties for improvement. If there is weakness of the res
begins with the information collected from the diag piratory muscles, then the results obtained reflect the
nostic data. Great benefits can be gained from under patient's breathing capacity based on weak muscles.
standing the information, but it is equally essential to This leaves open the option of improving the respira
recognize its limitations. tory muscle strength to see how it may affect the ven
tilatory capacity. Once you begin to think critically,
many windows may become apparent that can provide
Critical Usage of Pulmonary Diagnostic Reports
options for improving the results. For example, if a
The diagnostic criteria for secondary cardiopul patient with scoliosis has reduced volume capacity, it
monary dysfunction is similar to diagnosis criteria for is unclear if it is a fixed piece of data or if there is
primary cardiopulmonary dysfunction. In the short room for improvement from the perspective of posture
and strength. The volume and flow measurements of a
patient with a lot of secretions would be reduced be
cause of the obstructive nature of the mucus. If that
patient was on an aggressive program of postural
THE FOUR Ds
/ Disease
drainage, would those values improve? Address
whether the values obtained in the pulmonary function
tests reflect a fixed, irreversible value. The author's
\
Depression
J
Deconditioning
clearance of mucus work to improve values otherwise
believed to be unchangeable.
X-ray
FIGURE 24-1
Flow of progression of respiratory disability. This The use of x-ray testing is critical in identifying infil
demonstrates the chronic cyclic pattern that haastens trates, pneumonias, tumors, and obstructions. Yet it
deterioration and death. too has its limitations and should not be relied on
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24 Exercise Testing and Training: Secondary Cardiopulmonary Dysfunction 427
solely to assess a patient's capabilities. Mr. K had a stood that patients will be more comfortable and
diagnosis of chronic obstructive lung disease with ex probably perform better on equipment that mimic
tensive scarring from old tuberculosis. His x-ray was their present life styles. Although the step test that
opaque. No viable ventilating lung tissue was seen on has the patient going up and down a step at a given
the left side. Ausculation with a stethoscope revealed rate is effective in identifying a change in the blood
no breath sounds. Yet after months of breathing re gases, a patient may feel more comfortable and be
training, thoracolumbar mobilization and soft tissue able to last longer on either a bicycle or treadmill.
mobilization, this patient established a most definite Furthermore, during a step test, the patient may fa
improvement in breath sounds on the left side. No tigue after only a few repetitions. There is more op
improvement was noted in his x-ray. So, our tools are portunity to evaluate the following: (I) how quickly
helpful to a point, and we should always give our pa the gases change, (2) if they improve over time, and
tient the benefit of the doubt and try. (3) the dynam ics of breath ing mechanics when
choosing a modality that the patient may be able to
Auscultation sustain over a longer period of time.
The stethoscope is effective in identifying many ab
normalities within the lung, such as bronchospasm,
Respiratory muscle strength and endurance
mucous collection, consolidations, and infiltrates. Yet The foundation of the respiratory system's ability to
it is not uncommon to hear perfectly normal breath work is the strength and endurance of the respiratory
sounds, and the patient will still report tightness in the muscles. Strength and endurance form the foundation
chest, wheezing, and even congestion. It is always im because breathing is an ongoing activity from which
portant to have the patient cough or breathe deeply to the body cannot take a vacation; it requires the en
increase the flow of air so as to pick up any of these durance to continue without stopping. There are times
abnormalities. Yet even if this is done and the breath when the respiratory system requires sudden bursts of
sounds seem normal, always defer to the patient. increased strength, as is evidenced by the need to
cough. Factors predisposing to fatigue are related to
Arterial blood gases muscular ability, ventilatory mechanics, reduction of
Arterial blood gases are designed to measure the energy supply by hypoxemia, reduced cardiac output,
level of oxygen, carbon, dioxide, and pH in the arter and malnutrition. The measure of respiratory muscle
ial blood (see Chapter 9). It reflects how effectively strength is done via a gauge that measures inspiratory
the respiratory system is working in supplying the muscle strength and expiratory muscle strength (PI
body with the fuel to carry on the task of living. It is max and PE max). A patient unable to generate 60%
quite common to receive an order for physical ther to 80% of these values reflects respiratory muscle
apy including exercise with the information that the weakness (Edwards, 1978). A patient who is unable to
blood gases are within normal limits. It is critical to maintain expected respiratory muscle force with con
identify if the blood gas values were taken at rest or tinued or repeated contraction demonstrates the level
after exercise. If exercise blood gases are not i n of respiratory muscle fatigue, which is the precursor
eluded in the report, there is no way of knowing how of respiratory failure (see box below). A thorough
the patient's oxygenation will be affected by activity
(desaturation). It is possible to have normal resting
blood gases that drop precipitously with activity. This Clinical Signs of Respiratory Muscle Fatigue
can be a result of limited ventilatory ability or venti
Hypoventilation
lation-perfusion mismatch. It is the responsibility of
Rapid shallow breathing
the therapist of a patient with compromised ventila
tory ability to request exercise blood gases or use an Paradoxical breathing
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428 PART III Cardiopulmonary Physical Therapy Interventions
History-Critical Listening
o
o 27 40 60 80 100 150
In attaining a history from the patient, it is critical to
work slowly, so that the patient feels comfortable, P02 mm Hg
and to encourage what could be deemed as simple
FIGURE 24-2
chatter. After discussing a patient's personal inter
Oxyhemoglobin dissociation curve. Demonstrates the point
ests, family, and home life you will have the informa at which oxygen saturation drops precipitously to between
tion to recommend an intervention program that will 40 and 60111111 Hg
be beneficial for the patient and that the patient will
actually do. If it is felt that the patient can improve ally open the perspective of hope for improvement.
his or her endurance to be able to walk a mile and the Because it is not just one system that becomes sud
patient is only interested in walking a few blocks, the denly ineffective, physical therapists have the latitude
goals have to be set accordingly. Some therapeutic to explore the full course of the history and look for
techniques require a quiet passive posture by the pa the gaps where an intervention can be directed. Has
tient. A more tense individual who is pressed for time posture changed over time? Has there been progres
will not tolerate that kind of intervention. It is there sive weakness? Have activity levels diminished?
fore crucial to take the time to get the total picture. Were there frequent respiratory infections? Re
From the perspective of the history of respiratory sponses to each of these questions can greatly influ
symptomatology, it is common to hear, "I don't know ence factors in a rehabilitation program. If a patient's
what happened, I was doing just great until r got that posture deteriorated over the years, compromising
cold ... then it all fell apart." Pursue the investiga respiratory ability, a program of stretching and
tion, because undoubtedly the history is much longer. strengthening of the postural musculature may pro
The difference is that the patient was able to cope and vide sufficient space in the thoracic wall for im
the presenting situation became excessive. The oxy proved lung capacity and oxygenation. It takes a
hemoglobin dissociation curve in Figure 24-2 demon small amount of objective improvement to make a
strates the underlying physiological process (Stoller, big difference in the quality of life for the individual.
1988). Looking at the S curve, one can see that above Regardless of the underlying cause, attaining a Pao2
60 mm Hg the curve is fairly flat, and Joss or deple of at least 60 mm Hg is the primary concern.
tion of oxygen above the level can go undetected Because the work of breathing becomes very diffi
clinically. However, as the curve demonstrates, there cult in primary lung diseases or restrictions secondary
is a critical point around the Pao2 of 60 where the to other disease processes, the symptomatic presenta
person will "suddenly" experience severe shortness tions can be quite similar. It very closely simulates
of breath. In reality the oxygen level was dropping the posture of the marathon runner at the end of a
progressively over time but was only critically felt at run. The runner assumes a bent forward posture,
the drop of the curve. Understanding the progression leaning on a wall or gaining support by leaning on
of the deterioration with shortness of breath can actu the knees (Figure 24-3). This position is optimal for
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24 Exercise Testing and Tmining: Secondary Cardiopulmonary Dysfunction 429
FIGURE 24-3
The flexed fOlward posture held when experiencing sho rtne ss of breath. Simi lari t ies between the healthy
marathon runner and the person with chronic respiratory difficulty should be considered in reference to
muscular, skeletal and pressure changes. (Courtesy of David Gorman, The Body Moveahle)
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430 PART III Cardiopulmonary Physical Therapy Interventions
enhancing diaphragmatic excursion. After a few mO baseline exercise test to identify exercise capability.
ments, the runner will get up and walk away. Unfor It would be premature to begin an exercise training
tunately, the patient experiencing shortness of breath program. The first step wou Id be to address improve
stays in that bent forward position. A patient may ment of strength and posture. The goal is directed to
stay that way because it is easier to breath or because ward improvement in height, lung capacity, and mus
he or she does not realize the precipitating event has cle strength. The baseline data on the exercise test
passed. The point of emphasis is that any chronic dis would likely improve. An exercise test subsequent to
ease resulting in shortness of breath will have pos postural improvement would be a better baseline for
tural effects. Look for limitation in range of motion an endurance training program.
of the hips and poor mobility of the thorax and the For the patient with underlying neuromuscular
pelvis. This can be evident in a gait pattern that has disease, an endurance training program may overfa
minimal rotation of the thorax on the pelvis. The tigue muscle groups and cause damage. Therefore
stride length will be shortened, with minimal arm the exercise test, again, is to get a baseline of exer
swing and an overall stiff, nonfluid gait pattern. The cise ability. The therapeutic intervention would be
gait pattern of those suffering with chronic shortness directed toward muscle re-education, postural exer
of breath and its associated postural changes can be cises, and strengthening to help the patient move
described as walking cinder blocks, implying that the more efficiently and reduce stress on the affected
muscles from the neck to the pelvis are fixed and do m u s culature. The i m p r ovement in posture and
not allow for normal reciprocal movement. strength provides a better baseline to sustain an exer
cise test and subsequent training.
A timed-walk test for a patient with severe limita
Exercise Testing
tion would be appropriate. Measure a walkway in 10-
Exercise testing is performed for a variety of reasons. foot increments and then time the distance walked for
It is a means of (1) gaining baseline information of either 6 or 12 minutes. It may be necessary to further
the patient's activity level, (2) assessing functional modify this test into distance walked for 2 minutes.
ability,(3) prescribing graded-exercise programs, and Instruct the patient to walk as far as possible as fast
(4) evaluating cardiovascular ability. The choice of as possible for the timed segment. Record distance
exercise testing should reflect the needs of the pa walked. Monitor the blood pressure, heart rate, respi
tient, the cost-effectiveness of the procedure, and the ratory rate, ventilatory muscle use, and O2 saturation.
consideration for the need of extensive diagnostic in A patient at a higher level of function may benefit
formation and its practical application into the pa from a more aggressive exercise test that allows for a
tient's life. The patient's addressed in this chapter are more accurate level of cardiovascular response to ex
by and large severely limited in their physical abili ercise as a basel ine for prescription for endurance
ties because of their underlying disease processes and training. A baseline level is first obtained from the
their secondary respiratory effects. Typically the timed-walk test or the patient can walk on the tread
overall presentation is one of atrophy, decondition mill at 1 to 2 mph, 0% grade for 6 minutes.
ing, and poor mobility that greatly limits the distance A patient whose exercise ability is limited by respi
walked. The severely limited patient would benefit ratory factors before the healt rate or blood pressure is
with a simplified exercise test to identify exercise ca even elevated does not rt;quire a full-graded exercise
pacity. When considering the patient with secondary test with full ECG, metabolic gas analysis, heart rate,
cardiopulmonary restriction, treatment should be and blood pressure measures. Interest should be more
aimed at improving the cardiopulmonary status con directed toward the following:(I) how far can this per
current to the underlying primary process. A few ex son walk, (2) what happens to his breathing pattern and
amples can better illustrate this point. The scoliosis respiratory rate, and (3) does the oxygen saturation
patient who has progression of the spinal deformity drop. Based on this, recommendations can be made for
and secondary pulmonary compromise requires a use of supplemental oxygen and possibly more efficient
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24 Exercise Testing and Training: Secondary Cardiopulmonary Dysfunction 431
Exercise Training
breathing patterns to allow the patient to persevere
longer. For example, if a patient has a diffusion prob Design of an exercise prescription must be individu
lem or a ventilation/perfusion mismatch, it would be alized and must be prescribed within both useful and
helpful to evaluate whether a slower pace would allow achievable levels.
the patient to walk longer. Consider enhancing the time Exercise training should not be limited to a mode
allowed for diffusion of the oxygen. It may be found of exercise equipment, duration of time, or fre
that a slower pace, with attention directed toward deep quency. A person with a chronic condition has
effective breathing, may yield different values in oxy chronic manifestations physically and psychologi
gen saturation and the distance walked. The choice of cally. Therapy directed toward the chronic physical
testing modality should also take place or location into changes, that is, postural and overall movement, can
consideration. It seems inappropriate to demand that a result in improved endurance. This perspective
severely limited patient being seen in the home undergo should be seriously considered before using preciolls
extensive graded-exercise testing before recommending therapeutic time to put a patient on a treadmill three
an exercise program. The choice of exercise testing times per week to measure a heart rate that does not
should reflect the goals of the patient. If the patient is elevate because the patient is too short of breath. The
ready for an aggressive exercise program, then more severely limited patient may benefit from general
extensive testing is appropriate. Testing can then body movement for a duration of 10 to 15 minutes. It
progress to stage II. A treadmill stess test begins with a could include standing and leaning on a chair and
speed that is comfortable for the patient-usually be shifting the hips to the rhythm of music. The goal is
tween 2 to 3 mph. Work is increased every 3 minutes initially just to move, create a challenge to the car
by either increasing the speed or the incline. It is rec diorespiratory system, focus on controlled hrcathing,
ommended to increase the speed by 0.5 mph incre and show the patient that he or she can sustai n move
ments, maintain it at a comfortable walking pace, and ment for prolonged periods. The therapeutic ball has
progress the incline by 2.5% increments after a com proven to be beneficial. The 65-cm ball is a good
fortable pace has been established. Measurement of size for a patient to sit on (Figure 24-4). It provides
heart rate and blood pressure should be taken at the end support yet allows for movement. Many severely
of each 3-minute stage and Sa02 oxygen saturation limited patients have been able to sit on a ball shift
should be monitored throughout and recorded at the be ing their weight from side to side, working on leg
ginning and end of each stage. strengthening, pelvic and spinal mobility, and chal
The test is terminated in the following situations: lenging the cardiorespiratory system. Once a capahle
(I) when the patient reaches 65% to 75% of predicted patient becomes interested in a traditional endurance
maximal heart rate, (2) if oxygen saturation drops training program, the graded-exercise test can pro
below 90%, (3) if the blood pressure drops with in vide the necessary information to prescribe one. The
creasing activity, or (4) the patient experiences symp prescription should include intensity, duration, fre
toms of shortness of breath or muscular discomfort. quency, and modality as follows: (I) Intensity is
If a patient is able to reach 65% of predicted based on 65% to 80% of the predicted heart rate or a
maximum heart rate without cardiop u l monary level where the patient becomes symptomatic or the
symptoms, then the patient is capable of exercise oxygen saturation drops to 90O/C . Consider, for exam
conditioning. Oxygen saturation should be above ple, an exercise test that is terminated after walking
90%. Below this level requires supplemental oxy at a speed of 3 mph, at a 5% elevation, 3 minutes
gen. If the carbon dioxide (C02) increases more that into lhat level. If the limiting factor was shortness of
10 torr of resting level, the patient will be limited in breath with a drop in oxygenation, further testing
exercise potential. Individuals who reach their maxi should be conducted with the use of supplemental
mum volume ventilation (MVV) with minimum in oxygen. If the limiting factor was shortness of breath
tensity exercise may have difficulty with an en without a drop in oxygen, 2.5 mph at 0% elevation
durance training program. can be used as a 5-minute warm-lip, followed by
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432 PART III Cardiopulmonary Physical Therapy Interventions
training at 3 mph for up to 15 minutes with I minute Caution is advised in understanding the underly
intervals at 2.5% elevation followed by a cool down ing pathology that resulted in cardiopulmonary limi
of 2.5 mph, 0% elevation, for 5 minutes. (2) Dura tations. Post polio syndrome is characterized by
tion of exercise is 15 to 30 minutes per session. Ini muscles that were weakened during the initial onset
tially this can be broken down into interval training of the disease and more recently report a recurrence
where short 1- to 2-minute rest periods can be used of symptoms. Studies have shown that these patients
progressively, lengthening the intervals until the pa benefit from strengthening and endurance exercise,
tient is able to maintain a c o ntinuous session. but extreme caution must be directed toward avoid
(3) Frequency of e xercise is three to five times a ing overuse (Dean, 1991 a; Owen, (985). The patient
week on alternate days. (4) Modality depends on pa will benefit from a carefully considered, judicious
tient comfort. The target heart rate, or the level be exercise program.
fore the patient developed symptoms, is used as the
training level. Flexibility exercises or slow walking
SYSTEMATIC APPROACH IN THE
are recommended for warm-up before the endurance
REHABILITATION PROCESS
exercise program.
Nocturnal Ventilation-The Role of Rest
and the Respiratory Muscles
FIGURE 24-4 nothing and allowing the patient to accept life with
Therapeutic ball as part of a program of improving mobility the shortness of breath and promote further atrophy
and endurance. and (2) pushing too hard and risking breakdown of
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24 Exercise Testing aod Training: Secondary Cardiopulmonary Dysfunction 433
the respiratory system. It is the responsibility of the for good clinical judgement. Sometimes the patient
therapist to be aware of the diagnostic and clinical has a bad day and just does not do well, other times
signs of respiratory muscle fatigue. he or she may be in trouble.
Diagnostic criteria for respiratory muscle fatigue
include the following: (I) increasing pulmonary arte
Managing the patient with clinical
Respiratory Muscle Function Assessment respiratory muscles before it reaches the stage of res
piratory fatigue and failure. This is accomplished
Pulmonary function test
through nocturnal ventilation using positive- or nega
•
Effort and strength dependent tive-pressure ventilators (Figures 24-5 and 24-6). The
• Respiratory muscle strength focus is to increase muscle energy supplies and
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434 PART III Cardiopulmonary Physical Therapy Interventions
FIGURE 24-5
FIGURE 24-6
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24 Exercise Testing and Training: Secondary Cardiopulmonary Dysfunction 435
initiating a progressive exercise program or for that breath hold. Activities can be divided into two cate
matter, any sort of exercise program, it is important gories. Static activities and rhythmic activities. Static
to assess the level of respiratory fatigue under which activities are those that are done once. For instance,
the patient is living. Symptoms, clinical observations, picking up a shoe. It is done once, until you are ready
or historical findings that are suggestive of further in for the second shoe. The first rule of thumb is to take
vestigation into the benefit of nocturnal ventilation a breath in before the activity to supply the body with
include sleep disorder, progressi ve dyspnea, hyper the oxygen it needs, then exhale with the activity. It
capnia, and dyscoordinate breathing patterns. It has is simple but it actually helps, and the patient is able
been recommended that a patient be allowed suffi to perform an activity with less shortness of breath.
cient time to adjust to nocturnal ventilation before ad The second rule of thumb is to maintain a rhythm
vancing into an active exercise program. This deci with activity. If the activity is washing dishes, vacu
sion must be made with medical guidance. It is uming the carpet, or climbing some stairs, the focus
sometimes recommended that a patient rest on this is to maintain a rhythm. That rhythm will change as
system for a few months to allow the body to reach a the activity continues, but the idea is to control it
stable level of metabolic rest. through the purse-lip breathing. For example, climb
ing stairs may begin with ease and become more dif
ficult with each step. Breathe in on step one and ex
BREATHING TRAINING
hale for step two, three, and four. As the activity
Paced Breathing
continues, modify according to the patient's need. It
These techniques are taught regardless of which mus may progress to breathing in on one step and doing
cles patient uses to breathe. Because breathing is the fu II exhalation on the second step. The patient
g
something we do all day lon , it is unfair to expect may still experience shortness of breath but will have
patients to alter their breathing continuously. There better control and get further.
fore it is helpful to break down breathing into various
components. Foremost is coordinating breathing with
Signs of Improvement
activity. If a patient is short of breath, he or she needs
to know how to get it back. Pursed-lip breathing is an The direction toward improved posture and more effi
effective means of helping. Pursed-lip breathing cient quality of movement is a slower process and
works as the center for controlling the respiratory rate should be directed in the realm of kinesthetic aware
and maintains more efficient emptying of the lung. ness. If you are working with a patient and find that in a
Paced breathing and the rule of thumb are handy certain posture you observed a better breathing pattern
tools that help get through daily activities. Breathing or that with a certain relaxation technique the patient
has a rhythm of inhale and exhale. Generally, the ex found relief, you want to harness that sensation. Repeat
hale is longer than the inhale. At rest and with vari it, use tactile input, have the patient close his or her
ous relaxation techniques, it is possible to greatly ex eyes and imagine it. If the patient has just learned to
tend the length of the exhale. For example, if at rest relax the upper thorax and get a good expansion in the
the person inhales for a count of two, the exhalation lower thorax, he or she will not be able to walk out of
might be for a count of four or five. With deeper re that session and breathe that way continuously. How is
laxation the length of the exhalation can be extended this new skill incorporated into a new pattern of breath
to the count of five, six, or even longer. Patients are ing? It is effective to stop 20 to 30 times per day,
encouraged to develop and heighten this sense of (1) pause, (2) relax the shoulders, (3) focus on the area
awareness and begin to coordinate it with activity. to expand, (4) do the breathing technique for a few rep
The concern is that frequently a person will perform etitions, and (5) concentrate on it and put it away. The
an activity (i.e., bending down to get a shoe, reaching focus of this exercise is not strength training but rather
to open a door, washing hair, or lifting a package) kinesthetic awareness. About 2 weeks of this compul
and during the activity actually stop breathing or sive stopping, sensing. and being aware is enough time
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436 PART III Cardiopulmonary Physical Therapy Interventions
that it becomes the way the patient breathes, becoming parted slowly, as opposed to thrust or high-velocity
incorporated into the patient's pattern of breathing. This manipulation. The intent is to regain normal active
obviously will not be successful with someone who range of motion, thus improving alignment and
mechanically, muscularly, or neurally is incapable of stress distribution. The improvement in joint func
this parit cular tion increases a joint's adaptive potential to mechan
panded using the tools of imagery. Too often a patient ical stress and reduces the possibility of re-injury to
is taught how to brcathc and does so beautifully in the that joint.
therapy session and then resumes the old pattern after
leaving the office. It is a difficult task to incorporate a
Soft Tissue Therapies
movement performed in a static stationary position and
maintain it during the dynamics of daily life. The The purpose of soft tissue therapy is to normalize ac
power of suggestion and imagery can be used here. tivity of the muscle fibers, restore extensibility, and
This scenario becomes a home exercise program of reduce pain. Soft tissue mobilization includes mas
gaining control of the breathing system. Even if the pa sage, accupressure, and soft tissue stretching. It uses
tient cannot maintain it through the whole process, it is low-intensity pressure and should not cause pain. If
a crucial activity in self-control and minimizes the applied properly, its techniques should result in local
sense of panic that goes along with activities that result and general relaxation, and reduction in tone. Myofa
in shortness of breath. It is a very beneficial activity cial release is a method to normalize myofacial activ
that can then be further advanced while working on a ity, regain tissue extensibility, and reduce pain. It is
bicycle or treadmill. The underlying emphasis is opti based on neuroreflexive responses that reduce tissue
mizing the patient's efficiency of movement and tension. With the appropriate application of manual
breathing and reducing the work of breathing. contact and the determination of the best point of
entry into the musculoskeletal system, a relaxation of
tissue tension and decrease in myofascial tightness
OVERVIEW OF THERAPEUTIC OPTIONS
can be attained.
A myriad of therapeutic techniques exist that are vi
able options in trying to maximize breathing oppor
Neuromuscular Therapy
tunities. It is beyond the scope of this chapter to
elaborate on the technique, rationale, and method of Proprioceptive neuromuscular facilitation is a method
all the options appropriate for the population. Once of promoting the response of the neuromuscular
asked by a colleague the appropriate treatments for mechanisms through stimulation of proprioceptors.
respiratory patients, I replied, "the same as with any The application of a manual stimulus is used to elicit
disease process." Evaluate the total situation and efficient neuromuscular responses. Its primary objec
plan an intervention that will reduce stress and in tive is to develop trunk or proximal stability and con
crease opportunity. If the patient population has de trol, as well as to coordinate mobility patterns. It can
veloped respiratory problems secondary to an under be used to help stabilize vertebral motion and im
lying d i s e a s e, p o s ture, muscle l e n g t h , m u s c l e prove spinal movement control.
strength, and endurance should be considered. The Muscle energy works under the principle that
manual therapies are excellent vehicles in gaining muscular activity can be used to restore physiologi
access to improvement. cal joint motion. It uses active muscle contraction
at varying intensitics from a precisely controlled
position in a specific direction against a distinct
Mobilization: Thorax, Rib Cage, Pelvis,
counterforce. It is used to mobilize joint restric
Sacrum, Hip, Shoulders, and Neck
tions, strengthen weak musculature, stretch tight
Joint mobilization is a nonthrust manipulation. Pres myofascia, reduce muscle tonus, and improve local
sures may vary from gentle to vigorous but are im circulation.
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24 Exercise Testing and Training: Secondary Cardiopulmonary Dysfunction 437
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438 PART III Cal'diopulmonary Physical Therapy Interventions
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24 Exercise Testing and Training: Secondary Cardiopulmonary Dysfunction 439
be generated on the left to enable the patient to with the patient reporting "Oh, I am getting more air!"
(I) shin the myocardium back into the left thoracic This was easily confirmed; improved aeration was au
cavity, (2) increase his vital capacity enough to reduce dible with the stethoscope.
his need for oxygen and possibly prevent future respi
ratory complications. Mr. L began a home program Problem 3: Poor endurance
using Theraband, which he looped around his left
Mr. L had become so deconditioned and anxious at
shoulder and held across his chest with his right hand
the thought of movement that he was unable to walk
(Figure 24-8). This position allowed him to grade re
even 20 feet. Outdoor ambulation created severe anx
sistance to scapular adduction, elevation, and depres
iety for which he was receiving psychological ther
sion. He also used weights in trunk exercises. Therapy
apy. He began a gradual program with walking in
sessions focused on manual techniques to mobilize the
place at 2-minute intervals. It is important to note that
rib cage, stretch the muscles, and release the connec
he was extremely motivated and not only followed
tive tissue. The technique of the diaphragm and tho
his exercise program, but expanded on it (Figure 24-
racic release were remarkably effective in opening the
9). He also used the P-FJex respiratory muscle trainer
breathing. This method alone was frequently effective
attached to his tracheotomy tube beginning on level I
for IS-minute intervals, twice a day.
After I year on the program, Mr. L grew in height
I 114 inches and increased his vital capacity by 700
ml, he no longer required supplementary oxygen, and
his myocardium shifted into the left thoracic cavity
without any signs of right ventricular strain. His ejec
tion fraction was 45%. He still demonstrated para
doxical motion with respiration, but there was a sig
nificant reduction in the amount of sucking in of the
lower rib cage on the left with inhalation. Ausculta
tion was remarkable with excellent breath sounds on
the left and right and some reduced air movement
near the lingula. Mr. L progressed up to walking in
place for 25 minutes with 2-pound weights in both
hands (he is able to clasp a weight with his paralyzed
hand) and attached to both ankles. He gained enough
motion in his neck to allow for full range of motion.
Because the pull of gravity will continually work
on Mr. L to pull him back into dysfunctional patterns,
it is impOltant to keep Mr. L on a program. He is seen
once every 2 months to modify and update his exer
cises and work on his trunk to ensure optimal thoracic
capability. Over this extended time other windows
have been found working on his sacrum and pelvis.
Manual traction, mobilization techniques, and soft tis
sue releases in these areas all provide for improved
thoracic expansion. Hand placement on the sacrum al
lows for a slow release and relaxation of the upper
FIGURE 24-8 chest. Manual techniques then followed, encouraging
Creative use of theraband in strengthening of the thoracic progressively increasing diaphragmatic excursion. Mr.
musculature. L is able to cue in to changes in his body and work on
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440 PART III Cardiopulmonary Physical Therapy Interventions
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24 Exercise Testing and Training: Secondary Cardiopulmonary Dysfunction 441
surviving muscle fibers. Studies show that the di primary foundation of rehabilitation potential. Im
rection of therapy is to unload or rest the overused provement in breathing capacity and overall en
muscles and shift the work of the musculature. It is durance can be accomplished through techniques to
difficult in the therapeutic setting to identify the improve posture overall. Endurance training based on
weakness that may be from PPS or weakness from graded-exercise tests is an important element in the
simple aging and inactivity. Great caution is needed rehabilitation program but should be placed 10 per
in this situation because studies have shown that if spective to other therapeutic options.
the PPS muscles are overworked, it can result in
permanent irreversible damage. Dr. 0 presented
with the complaint of cervical pain. On evaluation,
REVIEWaUESTIONS
it became evident that the pain was related to the 1. What laboratory data are needed to determine if
cervical lordosis, resulting from the underlying a patient is a candidate for endurance training?
muscle loss aggravated by the stooped posture nec 2. What types of treatment can be beneficial, if a
essary for his long hours of work in the laboratory. patient is not a candidate for endurance training?
Dr. 0 primarily relied on his upper respiratory mus 3. What types of interventions can best help a patient
cles for breathing because of diaphragmatic paraly enter into a more aggressive exercise program?
sis and extensive intercostal muscle loss. Dr. 0 did 4. Is aerobic training limited to treadmi I I and bicy
not have much time available for home exercise or cle? Think about the limitations of these modali
for physical therapy sessions. Exercise prescrip ties and suggest alternatives.
tions that would isolate the weak muscles and then
focus on repetitive exercises to strengthen them
would be problematic because of the threat of tissue References
damage to muscles affected by PPS. Dr. 0 was
Astrand, P. & Rodahl, K. (1977). Physical Training. Textbook of
given one e x ercise to perform twice per day, work physiology. New York: McGraw Hill.
rolling, to roll from one end of the room to the Austin, J. (1992). Enhanced respiratory muscular function in nor
other and back. He was guided in maintaining con mal adults after lessons in proprioceptive musculoskeletal edu
cation without exercise. Che,'I, 102,486-490.
trol of the trunk musculature throughout the activ
Basmajian, J. (1993). Rational manu.al Iherapies. Baltimore:
ity. This activity was performed semi regularly for a
Willian,s & Wilkins.
year with the goal of improving trunk strength and Black, L. (1982), Early diagnosis of chronic obstructive pulmonary
posture. Over the course of the year, endurance ex disease, Mayo Clinic Proceeds 57,765-772,
ercises were added using a home stationary bicycle. Braun, N, (1983), When should respiratory muscles be exercised?
Chest, 84,76.
In I year, Dr. 0 grew I 1/4 inches. He continued to
Dean, E. (1991a), Clinical decision making in the management of the
rely on the upper respiratory muscles for breathing,
late sequelae of poliomyelitis. Physical Therapy, 71.' 757-761.
but his overall improved strength and posture left Dean, E. (199Ib). Effect of modified aerobic training on move
him pain free. ment energetics in polio survivor. Orthopedics, 14,1243-1246,
Edwards, R. (1978). Physiological analysis of skeletal muscle
weakness and fatigue, Clinical Science and Molecular Medi
SUMMARY cine, 54,463.
Feldman, R. (1985). The use of strengthening exercises in po s t
A multitude of therapeutic options exist for those suf
polio seq uelae : methods and results. Orthopedics, 81.889-891.
fering with respiratory limitations. The presentation Gorman, D. The body moveable. Guelph, Ontario, Canada:Amper
of symptomatology of dyspnea is similar in primary sand Printing Co,
lung disease and in secondary cardiopulmonary Kotses, H, (1981), "Application of biofeedback to the treatment of
asthma: a critical review, Biofeedback an d Self Regulation,
symptoms. It is crucial to understand the underlying
b,573-593.
pathology so that the therapeutic intervention and ex
Lisboa, C. (1985), Inspiratory muscle function in patients with se
ercise prescription reflect the potential of the patient. vere kyphoscoliosis, American Review of Respiratory Disease,
Focusing on issues of respiratory muscle fatigue is a 132,48-51.
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442 PART III Cardiopulmonary Physical Therapy Interventions
Marino, W. (1982). Reversal of clinical sequelae of respiratory Stoller. J. (1988). Oxygen therapy techniques-Current respiralol),
muscle fatigue by intermittent mechanical ventilation. Ameri care. Toronto: BC Della.
can Review ofRespiratOlY Disease, 125, 85. Upledger, J. (1992). Craniosacral therapy. Washington: Eastland
Owen. R. (1985). Polio residuals clinic: conditioning exercise pro Press.
gram. Orthopedics, 8,882-883. Weiss, H. (1991). The effect of an exercise program on vital capac
Shneerson, J. ( 1 97 8) . The Cardio respiratory response to exercise ity and rib mobility in pa tients with idiopathic scoliosis. Spine.
in thoracic scol.iosis. Thorax, 33, 457-463. 16, 88-93.
Copyrighted Material
Respiratory Muscle Weakness
and Training
Maureen Shekleton
Jean K. Berry
Margaret K. Covey
INTRODUCTION
to ventilatory failure and death. Causes of respiratory
Roussos and Macklem (1982) support the notion of a pump failure can be grouped into the following two
two-part respiratory system made up of the lungs, major categories: (I) those in which the respiratory
which are the gas exchanging organs, and a pump, drive is decreased or the sensitivity and function of
which ventilates the lungs. The pump is composed of the respiratory center is altered (i.e., those that affect
the chest wall, the respiratory muscles, and the nerves the central nervous system control), and (2) those in
and centers in the nervous system that control the res which the ventilatory response is decreased through
piratory muscles. The respiratory muscles are ex impairment of the mechanics of respiration (i.e.,
pected to function continuously throughout life to those that affect the chest wall or musculature) (Groer
p rovide the appropriate level of ventilation for meet and Shekleton, 1989).
ing the body's metabolic needs. The focus of this chapter is on the latter category,
Citing the analogy of the heart as the circulatory and more specifically, on the role of weakness and fa
pump and the consequences of heart failure, Mack tigue of the respira tory muscles as a pathophysiologi
lem (1982) maintains that the respiratory pump can cal mechanism seen in many clinical conditions. The
fail, leading to a condition characterized by hypoven view of respiratory muscle fatigue as a cause of venti
tilation and hypercapnia that may ultimately progress latory failure is an idea becoming more widely ac
443
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444 PART III Cardiopulmonary Physical Therapy Interventions
cepted among pulmonary clinicians (Sharp, 1984). of origin: central fatigue, transmission fatigue, or
Respiratory muscle fatigue is postulated to be the final contractile fatigue. Central fatigue is due to a de
common pathway to respiratory failure in all condi crease in neural drive, which reduces the number of
tions in which the respiratory musculature is affected firing frequency of motor units. The resulting force
(Cohen, Zagelbaum, Gross, Roussos, and Macklem, generated by voluntary effort is less than that which
1982; Grassino, Gross, Macklem, Roussos, and Zagel can be achieved by electrical stimulation of the motor
baum, (1979); Derenne, Macklem, and Roussos, nerves. If electrical stimulation can restore contractile
1978; Roussos and Macklem, 1982). force or if stimulation and force decline in parallel,
Although both the inspiratory and expiratory res central fatigue is present. Transmission fatigue results
piratory muscles are susceptible to fatigue, clinically, from an impairment in the transmission of impulses
concern centers on the inspiratory muscles. The di along the nerves or across the neuromuscular junc
aphragm is of particular interest. Under normal con tions. Contractile fatigue results from impairment in
ditions, the inspiratory muscles including the di the contractile response to neural impulses within an
aphragm, the external intercostals in the parasternal overloaded muscle. Both transmission fatigue and
region, and the scalene muscles are responsible for contractile fatigue are classified as peripheral fatigue.
the active process of breathing, and expiration is a Peripheral fatigue is present if force is decreased but
passive process. An analysis of the phenomenon of electrical stimulation is constant. All three types of
inspiratory muscle fatigue is presented initially in this fatigue are reversible (Mador, 1991).
chapter. This is followed by a discussion of the iden Peripheral fatigue can be further categorized ac
tification and management of inspiratory muscle fa cording to the selective loss of contractile force that
tigue and its possible prevention through training of occurs at varying stimulation frequencies. High-fre
the inspiratory muscles. quency fatigue is a selective loss of contractile force
at high-stimulation frequencies; low-frequency fa
tigue is the selective loss of force at low-stimulation
THE CONCEPT Of INSPIRATORY MUSCLE fATIGUE
frequencies. High-frequency fatigue is thought to be
It is important to differentiate between muscle weak the result of impaired neuromuscular transmission
ness and muscle fatigue, although both may lead to and/or propagation of the muscle action potential.
hypoventilation (Bryant, Edwards, Faulkner, Hughes, This type of fatigue is seen in myasthenia gravis, dur
and Roussos, 1979). Muscle weakness refers to a loss ing ischemic exercise, with muscle cooling, and with
in the capacity of a rested muscle to generate force partial curarization. It is reversible in minutes. The
that is chronic situation. Muscle fatigue refers to a mechanism underlying low-frequency fatigue is
loss in the capacity of a muscle under load to develop thought to be impaired excitation-contraction cou
force or velocity that is reversible by rest (NHLBI pling. Recovery from this type of fatigue may take
Workshop Summary, 1990). Fatigue is an acute loss hours to days and possibly longer. Intense dynamic
of contractile force wherein, despite constancy of and static muscular activity can lead to low-fre
stimulation, force declines from the initial value. If quency fatigue (Edwards, 1983; Moxham, 1990).
fatigue is the inability of a muscle to continue to gen
erate a required force, then in the respiratory system,
Mechanisms and Etiology of fatigue
fatigue will be manifested by the inability of the in
spiratory muscles to continue to generate the force re The major mechanisms thought to be responsible for
quired to maintain the necessary level of alveolar inspiratory muscle fatigue include an imbalance be
ventilation to meet the body's metabolic needs. Inspi tween energy supply and demand and impaired exci
ratory muscle fatigue occurs when inspiratory effort tation-activation. Edwards (1983) has proposed a
exceeds the capacity of the inspiratory muscles to model that accounts for the interaction of both mech
sustain that effort (Rochester, 1982). anisms in the development of muscle fatigue. He has
Physiologically, fatigue has been characterized as also proposed the idea that fatigue serves a protective
one of the following three types, depending on its list function in that serious irreparable damage may be
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25 Respiratory Muscle Weakness and Training 445
Possible
fatigue mechanism
Psyche
Brain
Impaired motivation
i.e. neural motor
drive and motor
unit recruitment
SP'''' Co ,d
) I mpaired reAex
drive
Muscle sarcolemma
j
Impaired action
potential
Impaired excitation
Ca**
1
Impaired activation
Impaired energy supply
Actin-myosin
interaction
Sarcomere damage
Force power
OUlput
FIGURE 25-1
Chain of command for muscular contraction and the possible mechanisms underlying fatigue.
(From Edwards, R.A.T. (1983). Biochemical basis of fatigue in exercise petformance: Catasptrophe
theory of muscular fatigue. In Knuttgen, H., Vogel, J., Poortmans, 1. (Eds.). Biochemistry of
exercise. Champaign, Ill. Human Kinetics Publishers.).
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446 PART III Cardiopulmonary Physical Therapy Interventions
prevented if the muscle is unable to continue per pattern of fiber distribution is most pronounced in
forming beyond a critical point. The central nervous the premature infant. This condition exists in infants
system may exert a protective mechanism to avoid for up to a year after birth.
these adverse effects. This idea has persisted and the The energy supply to the muscles depends on an
term central wisdom is used to describe the phenome intact oxygen transport system, adequate oxygen-car
non (Moxham, 1990) (Figure 25- I, p. 445). rying capacity of the blood, blood tlow, substrate
The energy demands of the inspiratory muscles stores and availability, and the efficiency of oxygen
are determined by the work of breathing, the strength uptake and uti lization by the muscles. The energy
and endurance of the respiratory muscles, and the ef supply to the inspiratory muscles is compromised
ficiency of the muscles. The work of breathing is the when cardiac output is reduced, the hemoglobin con
total amount of effort required to expand and contract tent of the blood is low, blood flow to the muscles is
the lungs. It is determined by the degree of compli decreased, or energy substrates are lacking.
ance of the lung tissue and the chest wall, the resis Excitation-activation depends on intact, function
tance of the airways, the presence of active expira ing, neuromuscular pathways. Impaired excitation-ac
tion (normally a passive process), and use of the tivation is probably the primary mechanism underlying
accessory muscles of respiration. The work of breath respiratory muscle weakness and fatigue in the patient
ing is increased by decreased pulmonary compliance, with a neuromuscular disorder (Edwards, 1979). Dis
increased airway resistance, active expiration, and ruption of excitation-activation can occur at any point
use of the accessory muscles. along this pathway, which Edwards (1983) refers to as
Strength and endurance are the fundamental prop a chain of command for muscular contraction. Pre
erties of muscle. Strength is defined as the maximal sented in Figure 25-1 is a list of the possible mecha
force that a muscle can develop with maximal stimu nisms that may lead to fatigue by disrupting the neuro
lation. Contractile force is governed by the force muscular pathway. Impaired excitation of the muscle
length (length-tension), force-velocity, and force-fre membrane is probably interrelated with energy metab
quency relationships. Contractile force diminishes in olism. For example, if the ATP supply to the Na+ - K+
conditions characterized by increased lung volume pump is compromised, an alteration in the Na+ and K+
(hyperinflation), since the muscles are stretched be concentrations in the transverse tubular system may re
yond the optimal length to generate maximal force. sult in impaired excitation-contraction coupling.
This stretching of the muscle fibers produces a less Although it is difficult to demonstrate the precise
desirable length-tension relationship and causes a mechanisms causing respiratory muscle fatigue in pa
loss of the zone of apposition, with resulting decrease tients, support is found for the concept that central
in strength generation. Strength is also determined by nervous system output is modified to avoid overt fa
the number and size of individual fibers in a muscle. tigue. With extremely high loads imposed on respira
Strength is adversely affected in conditions in which tory muscles, patients adopt a rapid shallow pattern
the size of the fibers is reduced (atrophy) or the num of breathing that reduces the work of breathing and
ber of fibers is reduced (e.g., in malnutrition). can be sustained. Eventually, this pattern of rapid
Endurance is defined as the ability to maintain a shallow breathing will lead to hypercapnia and acido
contraction against a given load and is determined sis (Moxham, 1990).
by muscle fiber type, blood supply, and the force In summary, those patients who are at risk for the
and duration of the contraction. Normally, the inspi development of inspiratory muscle fatigue are those
ratory muscles are fatigue resistant. Approximately in whom energy demands are increased, energy sup
75% of the muscle fibers in the adult diaphragm are plies are compromised, or whose neuromuscular
of the high oxidative, fatigue resistant type (type I chain of command has been disrupted at some point.
and type IIA). In contrast the diaphragm of the Patients at highest risk for the development of inspi
neonate contains a relative paucity of type I fibers ratory muscle fatigue are those in whom the work of
that have the greatest endurance capacity, and this breathing is increased, thus increasing the demands
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25 Respiratory Muscle Weakness and Training 447
for energy, and those who are experiencing hypox power spectrum, which is indicative of muscle fa
emia, acidosis, low cardiac output, or any other con tigue in normal subjects exercised to fatigue, in pa
dition in which the blood supply to the muscle is di tients experiencing difficulty being weaned from me
minished, thus reducing oxygen supply. Patients chanical ventilation, and in animals in whom fatigue
whose nutritional status is poor or who are experienc was experimentally induced. When fatigue is present,
ing a catabolic state, such as stress or fever, will have the ratio of high-to-low frequency power, which can
reduced energy stores and may experience muscle fa be detected by EMG, shifts as low-frequency power
tigue during times of high need. increases and high-frequency power decreases. The
difficulty in obtaining an EMG at the bedside and in
analyzing the results makes its use in most clinical
Assessment of Fatigue
situations unrealistic at this time.
The clinician will most often have to rely on physi In summary, rapid shallow breathing is the initial
cal signs exhibited by the patient to recognize inspi sign of inspiratory muscle fatigue (Yang and Tobin,
ratory muscle fatigue. Other laboratory methods that 1991). The physical signs previously described are
would yield more objective evidence of inspiratory reliable and can be used in a clinical situation to de
muscle fatigue include power spectral analysis of the termine whether the patient is experiencing inspira
electromyelogram (EMG), measurement of the max tory muscle fatigue.
imal relaxation rate, and examination of twitch oc
clusion pressure.
Treatment of Fatigue
The following signs are indicative of inspiratory
muscle fatigue and are listed in their characteristic The goals of treating inspiratory fatigue are as fol
order of appearance: lows: (I) restore the balance between energy supply
I. Tachypnea and demand, (2) improve diaphragmatic contractility,
2. Decreased tidal volume and (3) increase the strength and endurance of the in
3. Increased PC02 (which is a late sign) spiratory muscles. The last goal is obviously a more
4. Bradypnea and decreased minute ventilation long-term preventive approach, whereas the first two
Formerly, development of a discoordinated respi goals apply in the more acute situation when inspira
ratory pattern characterized by inward abdominal tory muscle fatigue is present.
movement on inspiration (a sign referred to as ab Energy demands in the patient experiencing fa
dominal paradox) and alternating abdominal and tho tigue can be decreased by reducing the work of
racic respiratory patterns (a sign referred to as respi breathing through activities intended to promote
ratory alternans) were t h o u gh t to result f r o m compliance, decrease resistance in the lung, chest
respiratory muscle fatigue. Presently, these changes wall and airways, and promote normal lung volumes
in breathing patterns are thought to result from in and pressures. Energy supplies can be enhanced by
creases in respiratory load rather than muscle fatigue ensuring maximal oxygen transpOit to the tissues and
(Mador, 1991; Tobin, Perez, Guenther, Lodato, and the availability of adequate amounts of oxygen and
Dantzker, 1987). However, discoordinated respira other energy substrates. Oxygen transport is en
tory patterns are important clinical signs of respira hanced by promoting adequate cardiac output, blood
tory distress and, although they are not specific in flow to the tissues, and oxygen-carrying capacity of
their etiology, they are sensitive indicators of impor the blood. Various forms of respiratory therapy are
tant declining respiratory function. available to supplement oxygen supplies. Losses of
In animals in whom inspiratory muscle fatigue has organic and inorganic energy in substrates must be
been experimentally induced the fall in respiratory replenished and adequate levels maintained. Nutri
rate and minute ventilation immediately precedes res tional supplementation and administration of elec
piratory arrest and death. This sequence of events has trolytes and inorganic phosphate may be necessary to
been observed after an initial change in the EMG augment energy supplies. Rest therapy with mechani
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448 PART III Cardiopulmonary Physical Therapy Interventions
cal ventilation may be required to allow the fatigued plished by training the inspiratory muscles in much
muscle to recover and to bring energy supplies and the same way that athletes train and condition their
demand into balance. muscles. Inspiratory muscle training may represent a
Much current research is being done in the area of useful clinical approach to prevent the development
pharmacological interventions to improve diaphrag of inspiratory muscle fatigue in those patients who
matic contractility. Aminophylline w as initially are at risk.
thought to increase the contractile force of the di
aphragm at any given level of activation, but further
INSPIRATORY MUSCLE TRAINING
research indicates that this drug increases muscle en
ergy consumption and potentiates fatigue (Janssens, Inspiratory muscle training (lMT) is currently used in
Reid, Jiang, and Decrarner, 1988). Other drugs with pulmonary rehabilitation to increase the strength and
inotropic properties are the beta-agonists. Clinical in endurance of the inspiratory muscles. Patients with
vestigation of the potential usefulness and application chronic obstructive lung disease experience func
of these pharmacological agents in inspiratory muscle tional weakness of the respiratory muscles, which can
fatigue is ongoing. contribute to dyspnea and functional impairment.
The last goal, that of increasing the strength and Theoretically, IMT should reduce dyspnea by im
endurance of the inspiratory muscles, can be accom proving respiratory muscle function and exercise tOI-
I
i Sirengill ,tlld cndurancc of respiralon' llluscies
I
Delay lhe onsel of
respiralory llluscle faligut'
IllllJrOl'e
I
Prel'em/dcler I hc Ollsel of
I
Illlpn)IT lissuc o"ygemllio)l
1'espi1';lIOl} insuUiciell(Y allcl • cog"niliol1
faliguc pcn:cplion
pS)Tilo-lllOI01' hlllCiioll
ImpnJl' 1m p1'Ol'c
signs anc! "mplOms \\ell-being.
Improl't' IlllprOl'c
tlaih liling life
FIGURE 25-2
Conceptual framework for respiratory muscle training. (From Kim M: Respiratory muscle training:
Implications for patient care . Hearl and Lung. 13(4):333-40).
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25 Respiratory Muscle Weakness and Training 449
erance. These effects have yet to be demonstrated in developed a model that outlines the relationship be
large, controlled studies (Smith, Cook, Guyatt, Mad tween the effects of a respiratory muscle training and
havan, and Oxman, 1992). potential patient outcomes (Figure 25-2).
General principles of skeletal muscle training that Inspiratory muscle training has been used to suc
must be considered when designing and evaluating an cessfully increase muscle strength and endurance in
IMT program for respiratory patients include over healthy volunteers and in patients with chronic air
load, specificity, and reversibility. To train a muscle flow limitation (Belman and Mittman, 1980; Larson,
to improve its functional ability, the muscle must be Kim, Sharp, and Larson, 1988), cystic fibrosis
subjected to a stress greater than its usual load (over (Keens, Krastens, et ai, 1977). Early Duchenne mus
load), the training must be directed at developing spe cular dystrophy (Wanke et aI, 1994), and in those
cific functional attributes (e.g., strength or endurance) who are quadriplegic (Gross, et ai, 1980).
of the muscle (specificity), and the training must be Theoretically IMT in patients experiencing acute
maintained or function will revert back to pretraining respiratory failure should promote improved function
levels (reversibility) (Kim, 1984; Sharp, 1985). of the muscles, and fatigue resistance should facili
The effects of strength training on the respiratory tate the process of weaning these patients from me
muscles may include an increase in the size (hypertro chanical ventilation. In conditions requiring full ven
phy) and number of the muscle fibers by an increase tilatory support, the respiratory muscles may contract
in protein synthesis by the muscle fibers and a de at minimal levels for a period of time, possibly lead
crease in degradation. Endurance training of the inspi ing to the development of disuse atrophy. As their
ratory muscles is thought to promote an increase in strength and endurance decrease, the inspiratory mus
the proportion of fatigue-resistant fibers in the di cles will be more prone to fatigue because of the in
aphragm, an increase in the metabolic capability of teraction of disuse, the underlying pathophysiological
the muscle, and a reduction in the susceptibility of state, and catabolic effects of stress. The ultimate ef
muscle fibers to the deleterious effects of exercise fect of these interacting processes will be difficulty in
(Leith and Bradley, 1976). Newer evidence suggests weaning the patient from the ventilator. An EMG pat
an improvement in neuromuscular coordination and tern of fatigue has been documented in the ventila
efficiency resulting from training (McComas, 1994). tory muscles of neonates who experienced difficulty
Strength training to increase the size and number of in weaning (Muller, Gulston, and G ade, 1979).
myofibrils requires a high load and a slow rate of rep Grassino et al. (1979) found an EMG fatigue pattern
etition. Endurance training to increase the metabolic in a patient being weaned from mechanical ventila
capability of the muscle requires exercise of a suffi tion. Cohen et al. (1982) found an EMG pattern of fa
cient load, speed, and duration, such that cellular con tigue in 7 of 12 patients who experienced difficulty
centrations of energy producing substrates drop to during discontinuation of mechanical ventilation.
minimal levels (Kim, 1984). Endurance training of Resolution of the fatigue pattern was observed in
skeletal muscle has been found to be most effective those neonates who recovered and in adult patients
when brief periods of fatiguing exercise are alternated who were successfully weaned (Andersen, Kann,
with periods of rest (Aldrich, 1985) and this concept Rasmussen, Howardy, Mitchell, 1978). There is some
may be applied to inspiratory muscle training regimes. evidence that respiratory muscle training may prove
Improvement in the strength and endurance of the to be an important adjunct therapy to facilitate wean
inspiratory muscles through training has the twofold ing in the patient who requires mechanical ventilation
effect of enhancing the resistance to inspiratory mus of acute respiratory failure (Aldrich and Karpel,
cle fatigue and improving ventilatory function. The 1985; Aldrich et ai, 1989; Shekleton, 1991). How
work of breathing is reduced and respiratory reserves ever, controlled studies have not been conducted in
are increased. Because the clinical signs and symp this patient population.
toms are diminished, the ultimate outcome for the pa Two techniques have been used for inspiratory
tient is an improved quality of life. Kim (1984) has muscle training: isocapnic hyperventilation (also
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450 PART III Cardiopulmonary Physical Therapy Interventions
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25 Respiratory Muscle Weakness and Training 451
SUMMARY
Edwards, RAT (1979). The diaphragm as a muscle: Mechanisms
Inspiratory muscle training and conditioning is a newer underlying fatigue. American Review of Respiratory [iseases.
area of research and treatment for the respiratory pa fJ9, (2 pt 2),81-84.
Edwards, RAT (19 83). Biochemislry of Exercise. Champaign, lL,
tient. As such, further validation of its efficacy and tar
Human Kinetics Publishers.
geting of specific patient populations at greatest risk
Grassino, A., Gross, D., Macklem, P., Roussos, c., & Zagelbaum, C.
for loss of inspiratory muscl strength will define its (1979). Inspiratory muscle fatigue as a factor limiting ex.ercise.
use in pulmonary rehabilitation programs. At this time, Bullelin European de Physiopalhogie Re.lpiraloire, 15, 105-111.
inspiratory muscle training looks promising as a means Groer, M., & Shekleton, M. (1989). Basic palhophysiology: A
holistic approach. (ed. 3). St. Louis, Mosby.
of offering the respiratory patient one possible method
Gross, D., et al. (1 980) . The effect of training on strength and en
of control over disease processes that are most often
durance of the diaphragm in quadriplegia. American Journal of
very debilitating and unrelenting in their course. Medicine. 68, 27-35.
Guyatt, G., Keller, J., Singer, J., Halcrow, S., Newhouse, M.
(1992). Controlled trial of respiratory muscle t raining in
REVIEW QUESTIONS chronic airtlow limitation. Thorax, 47, 598-602.
Janssens, Reid Jiang, & Decrame r. (1988).
I. What are three types of respiratory muscle fatigue?
Jardim, J., et al. (1982). Inspiratory muscle conditioning training in
2. Name two major mechanisms thought to be re chronic obstructive pulmonary disease (COPD) patients. Amer
sponsible for inspiratory muscle fatigue. ican Review ofRespiralory Diseases, 125. (pt 2 of 2), 132.
3. What factors determine the work of breathing? Keens, T., et al. (1977). Ventilatory muscle endurance training in
normal subjects and patients with cystic fibrosi s . American Re
4. What is the initial physical sign of inspiratory
view ifRespiralory Diseas'es, 116, 853-860.
muscle fatigue?
Kim, M.J. (1984). Respiratory muscle training: I mplic at io ns for
S. What rehabilitation techniques should be used to patient care. Hearl and Lung, 13, (4),333-340.
increase the strength and endurance of the inspi Larson, M., Kim, MJ. (1984). Respiratory muscle training with the
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Patient Education
Alexandra J. Sciaky
INTRODUCTION
in their care. Unless effective patient education is im
In cardiopulmonary physical therapy, sound treat plemented this opportunity will be lost.
ment is based on the physiological assessment of the The overall objective of this chapter* is to provide
patient. Similarly, effective patient education is based the clinician with an understanding of the principles
on the learning needs assessment of the patient and practice of effective patient education. To meet
(Rankin & Stallings, 1990). Cardiopulmonary patient this objective, patient education is defined and perti
education poses a significant challenge because the nent learning theories with examples of how they re
physical therapist's duties can range from teaching a late to cardiopulmonary patient education are pre
hospitalized cardiac patient to do a self pulse check to sented. The learning needs assessment of the patient
designing a series of community-based exercise is explained, followed by a description of patient edu
classes for senior citizens with emphysema. Meeting cation methods and materials. Because the effective
this challenge is important because the benefits of pa ness of patient education efforts are important to
tient education include reduced health-care costs, re evaluate, ways to determine this are addressed. Fi
duced patient anxiety, increased patient knowledge,
satisfaction with care, and incrcased quality of life. In
addition, physical therapists share the responsibility
'The author wishes to thank Jennifer L. Wai ters, D. Min. and
with other health-care providers of ensUling that pa Patricia Wren, MPH for their expertise in education and assistanc e
tients have the opportunity to make informed choices in preparing this man uscri pt
.
453
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454 PART III Cardiopulmonary Physical Therapy Interventions
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26 Patient Education 455
a belief in one's ability to attain a certain structural, and social elements are
level of Bandura terms this se(refficacy of the behavior. In
He argues that percei ved sel f barriers unpleasant side may limit or
efficacy influences all aspects of behavior including prevent undertaking the recommended behavior.
new skills and inhibiting or current The behavior-modification has its roots
behaviors, has the four pri theory and consists of
mary determinants: (I) performance accomplish environmental rewards and
ments, the strongest refers to ments in relationship to a specified behavior
the desired behavior and mastery over the man, 1993). The theme of this approach that an in
in increased dividual's behavior can gradually be
involves learning a set t o Becker (1
others, Iy those with rewarding out- behavior-modification frequently follows a
comes; (3) verbal and (4) one's physiolog- plan: "identify the problem; describe the
ical state as it relates to ability to perform a in behavioral terms; select a behavior
task. For example, a pulmonary rehabilitation that is identify the antecedents and con-
program increases a when he or set behavioral
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456 PART III Cardiopulmonary Physical Therapy Interventions
Date: _ _ _ _ _ __ __
I. (client's name), agree to (detailed descriptioll of required behaviors, time and frequency limitations)
in retun! for (positive reinforcements contingent upon completion of required behaviors: timing and mode of delivery
of reinforcements)
I. (provider's name), agrees to (detailed description of required behaviors, time and frequency limitations)
(Optional) I, (significant other's name), agree to (detailed description of required behaviors, time and frequency
limitations)
(Optional) Aversive consequences: (Negative reinforcements for failure to meet Illinium contract requirements).
We will review the terms of this agreement, and will make my desired modifications. on (date). We hereby agree to
abide by the terms of the contract describe above.
(From Janz NK, Becker MH, Harlman PE: Parienr Educ COUllS 5(4): 165-178, 1984).
devise and implemellt a behavior change program; to facilitate the desired behaviors in the patient. Ide
and evaluate the program." This plan is very similar ally, once the contract expires, the patient feels com
to the approach the physical therapist takes on being petent and is able to continue the desired behaviors
referred to evaluate and treat a patient. The physical without the external reinforcements.
therapist identifies the patient's deficits, describes
the problem(s) in functional terms, sets short-term
NEEDS-BASED APPROACH TO PATIENT EDUCATION
and long-term functional goals, designs a treatment
plan to meet those goals, implements the treatment The most important aspect of planning for patient ed
plan and reevaluates the patient. These similarities ucation is assessing the learners (Kopper, 1987). The
may facilitate the use of the behavioral-modification process of patient education requires assessment of
approach by physical therapists. the total patient, including an understanding of the
Health-care contracts can be useful in implement psychosocial, socioeconomic, educational, vocational,
ing the behavior-modification approach. An example and cultural qualities of the person (Verstraete and
of such a contract may be seen in the box above. The Meier, 1973). Assessing educational needs of the pa
contract should be realistic, measurable, and renew tient allows the physical therapist to determine what
able (Herje, 1980). Specific goals, time frames, be the patient needs to know to meet the desired cogni
haviors, and contingencies are written in the contract. tive and behavioral teaching objectives. This assess
The clinician and patient discuss, then sign the con ment also increases patient-teacher rapport and pre
tract. Positive and negative reinforcements are used vents needless repetition of already familiar material.
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26 Patient Education 457
the interview to document the patient's responses to Fine- and gross-motor skills
specific questions about his or her condition. Open Physical adaptations and responses to illness or
ended questions such as "What are the major prob stimuli
lems your illness has caused for you and your fam Affective
ily?" elicit more information than a multiple-choice
Attitudes
format. Written tests can be helpful in determining
Value-belief system
what patients already know when the tests are given
before any teaching. These tests can also identify Motivation (readiness to learn)
serving patients as they perform a skill, such as di Personal and societal resources
aphragmatic breathing, reveals whether or not the pa Amount of instructor contact and setting
tient can demonstrate the correct technique. The
Cultural influences (language. traditions, roles,
physical therapist can also pose questions to the pa religion. and life style)
tient during the demonstration to determine whether
or not the patient knows the rationale for the exercise.
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458 PART III Cardiopulmonary Physical Therapy Interventions
Your physical therapist would like to help you learn what you need to know to function as independently as possible
and manage your illness/disability. Please answer the following questions to identify your own needs.
Part I.
Name:
Your illness and/or disabi Iity is:
Part II. There are many different ways to learn. Please read the list of ways to learn below and circle the ones which
help you learn best.
Part III I would like to know more about: (Check all that apply to you.)
Exercise My medications
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26 Patient Education 459
mining what is important to the learner and facilitate learning activities. By identifying the patient's needs
motivation. What the instructor feels is important to the physical therapist can then make informed
learn may not be what the patient feels is important to choices in the course of planning and implementing
learn. Identifying what the patient values early will each patient education experience.
prevent instructor (and patient) frustration later.
Cultural influences and personal and societal re
Formulation and Prioritization of Goals
sources are included in the environmental area. Being
aware of the patient's life style, religion, traditions, As physical therapists set treatment goals for their pa
roles, and primary language are important for the in tients, they should also set educational goals. Treat
structor to assess to individualize the patient's learn ment goals usually describe functional outcomes
ing experience. Presence or absence of the patient's (e.g., the patient will perform a stand and pivot trans
resources may affect consistency in and access to pa fer from bed to chair, i ndependently) and they are
tient education. written in behavioral terms. Educational goals should
All five of these areas can be addressed with the also be written in behavioral terms. For example,
use of a learning needs assessment survey. See Figure "Mr. J will safely perform percussion and postural
26-2 for an example. By using a survey in combina drainage to Mrs. J's right lower lobe." The stated be
tion with the physical therapy patient evaluation, the havior needs to be measurable in some way. Motor
therapist can gather all the necessary information to skills can be observed, knowledge skills can be
create an optimal patient education experience. The tested, and safety can be documented.
survey in the box on p. 458 consists of three parts, Prioritizing the patient's educational goals in con
which can be adapted to any patient-care setting. In junction with treatment goals enhances the therapist's
the pediatric setting, some of the questions could be efficiency. Referring again to the learning needs as
asked of the parent(s) or rephrased to address elemen sessment survey (see the box on p. 458) to determine
tary-school-aged children. Part I primarily assesses what is important knowledge to the patient will guide
the patient's perception of the illness or disability and the therapist in creating the most appropriate prioriti
its impact on the patient's life. Part II lists a wide va zation of goals. Simplicity is usually best. Over
riety of teaching methods and asks the patient to indi whelming patients with a huge list of items to be ac
cate which methods are most useful personally. Part complished may discourage them before they even
III identifies specific topics about which the patient start. If the patient's learning needs are very great,
would like to know more. This part is also helpful in start by breaking down the list of goals into smaller
alerting the therapist that referrals to other members groups. Choose the most important goals and try to
of the interdisciplinary health-care team may need to accomplish them first. If you run into a series of fail
be made. For example, if the patient checked off ures, tackle the next group. Build on each success the
"what I should eat," the therapist should make a re patient experiences.
ferral to the dietician.
EDUCATIONAL METHODS
Interpretation of Findings . Method Selection
The next important step after gathering information Using the learning needs assessment survey (see the
with the learning needs assessment survey is to inter box on p. 458) will allow the clinician to choose edu
pret the findings. The physical therapist must look at cation methods that will facilitate optimal learning in
the answer to each item on the survey and use that in a given patient or group. The patient(s) can self-select
formation in the process of designing the content and the available learning methods that have the greatest
method for teaching that patient. Interpretation of the learning potential. A combination of methods may be
survey findings means applying the patient's current necessary to achieve the educational goals that have
health concerns and knowledge deficits to future been set. If a patient is not sure which methods to in
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460 PART III Cardiopulmonary Physical Therapy Interventions
dicate, the therapist can base the choice on the other therapist in determining the settings and populations
information provided in the survey (e.g., sensory in which the methods will be most useful. This is not
deficits, level of schooling, or type of information de a comprehensive list. In fact, some health-education
sired). Surveys generally require regular updates to challenges require truly innovative approaches.
ensure that all of the offered methods are listed and In 1988, for example, community health-care
the discontinued methods are removed from the list. providers in Boston were faced with a dilemma. The
incidence of acquired immune deficiency syndrome
(AIDS) among women of color was increasing and
Advantages and Disadvantages
Latino, African-American, and Haitian women were
Each education method has its own advantages and not receiving vital information about how to prevent
disadvantages. Table 26-1 shows 13 education meth the transmission of the human immunodeficiency
ods listed with their key advantages and disadvan virus (HIV). These communities were largely dis
tages. The table is designed to assist the physical trustful of the health-care establishment and were not
TABLE 26-1
Comparison Chart for Education Methods (Adult'i and children unless otherwise noted)
Reading Patient can refer back to material. Requires instlUctor follow-up for comprehension.
Low effort for instructor.
Lecture Time-efficient for instructor. Cost-efficient. Low interaction. May pacify rather than engage.
Demonstration Adds sensory data to learning. Allows for Instructor needs proficiency in skill to be
problem solving and modification. demonstrated.
Video Access to restricted areas. Portrays events that are Noninteractive. May pacify rather than
infrequent, costly, and difficult to reproduce. engage. Costly, requiring electronic
Portable. equipment. Difficult to control quality.
Audiotape Portable. Useful for sight-impaired learner. Requires electronic equipment.
Group discussion Effective use of instructor time. Enlarges pool Not as much individual attention given. Group
of real-life experiences. Nonthreatening to may be hard to control (e.g., too talkative,
some learners. Mutual support possible. shy,hostile). Strong facilitator skills needed.
Clubs, camps, Draws on community and individual resources. Same as above. Some risk of perpetuating
and retreats Needs less professional input and time. myths and false information.
Individual Instructor can tailor learning to student's Inefficient use of instructor time. Limited pool
instlUction needs and desires. More one-on-one time. of experience on which to draw.
Games and directed Helpful for children. Reduccs anxiety. Uses Scheduling space. Finding participants.
activities repetition. Fun. Unexpected experiences
can lead to new understandings or insights.
Computer programs Interactive, self-paced. Large information Expensive. Special equipment and space
capacity. Time-cfficient for instructor. needed. May require expert help.
Seminars and Diversity of instructors and formats. Pool Expense, scheduling, and space.
workshops of expel1s and community resources. Can
tailor content broadly or narrowly.
Role-playing Trial runs, problem-solving, simulated Threatening to some. Can be time-consuming.
experiences. Instructor needs to be skilled in techniques and
dealing with effects on participants.
Oral and written Can provide instructor with evidence of what Literacy and supplies required, if written. May
tests learner needs to be taught and what has been be time-consuming.
learned.
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26 Patient Education 461
swer questions of the staff and patrons of these estab Airway clearance techniques and suctioning
lishments to empower them to disann myths about Energy conservation and pacing techniques
AIDS, encourage other women to make appropriate
Stress management
behavior changes, and to make referrals to neighbor
Cardiopulmonary resuscitation (CPR)-basic life
hood health centers for testing and evaluation.
support
Teaching young children about their bodies and
Hemt rate, blooo pressure, and dyspnea self-monitoring
health may also require unique approaches. In 1993,
Nutrition
members of the interdisciplinary team caring for chil
dren with cystic fibrosis (CF) at Texas Children's Hos Medications (schedules. actions, and side effects)
pital, Houston, held a CF Education Day for the chil Use of oxygen and other respiratory equipment
dren and their parents. The children ranged in age from Medical procedures (e.g., cardiac catheterization or
7 to .1 I years old. To teach them about anatomy, a spe bronchoscopy)
cial anatomy apron was fabricated. The apron had life Community resources
sized removable "organs" made of stuffed fabric. The
Emergency procedures
children took turns wearing the apron and learned to
identify and locate the organs by removing and replac
ing the apron's heart, lungs, intestines, and pancreas.
By evaluating the advantages and disadvantages of
available education methods, the physical therapist
can choose the methods that are most effective and education experience. Although the physical thera
use them to their best advantage. Consideration must pist may not be responsible for teaching on all these
be given for cost, equipment, scheduling, labor, time, topics, she or he should be familiar with them as
site, flexibility, and reusability. For example, video they are taught by others on the health-care team.
taped presentations may be easy for the instructor to Educational materials on all of these topics have al
schedule, present, and reuse but they can be costly to ready been developed by a variety of health-care
purchase and require expensive equipment to view. providers, educators, and organizations and may be
available for physical therapists' use (see "Interdis
ciplinary Considerations and Resources").
Content
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462 PART III Cardiopulmonary Physical Therapy Interventions
skills just as we strive to improve our treatment sition the woman without disturbing the many tubes
skills. Being able to communicate ideas and receive and lines that were present. Later the woman ex
feedback from patients from diverse racial, ethnic, pressed that she did not want to have two physical
vocational, religious, and generational backgrounds is therapy clinicians working with her at the same time.
crucial for physical therapists. We develop rapport She confided to the nurse that it was because she felt
with our patients by communicating to them that we it was too much like the Jewish ritual washing of the
have an understanding of their illnesses or disabili body after death, which is traditionally pelformed by
ties, as they perceive them, and that we plan to inte two people. This interpretation of the therapy sur
grate their goals or priorities into the treatment plans. prised the physical therapy staff members who
treated the woman because they were also Jewish and
the thought never occurred to them. The next time tl1e
Teacher-Learner Relationship
clinicians went to see the woman, they explained why
According to Locke (1986), the primary step to under it was necessary for both of them to be present during
standing others, is an awareness of one's self. Ac the treatment. They also encouraged the woman to
knowledging one's own personal values, interests, and have other supportive people present and to play her
biases will significantly increase one's sensitivity to favorite recorded music during the therapy session.
ward others. The skilled teacher is aware of her or his
own communication style and its limitations and can
Patient Adherence
convey the desire to help despite those limitations.
The teacher-learner relationship that develops be The effectiveness of physical therapy treatment, or
tween physical therapist and patient largely is due to of any medical treatment, depends on the patient
communication between the two in the context of following the health-care provider's recommenda
culture. Communication is a two-way process con tions (adherence.) Unfortunately there is often a gap
sisting of verbal and nonverbal messages. The inter between what the patient is asked to do and what the
pretation of these messages depends on the cultural patient actually does. This gap, or nonadherence,
cues operating in the educational setting. Fairchild has an incidence rate estimated between 50% to
(1970) defines culture as all social behavior, such as 80% (Meichenbaum and Turk, 1987). Factors af
customs, techniques, beliefs, organizations, and re fecting patient adherence include knowledge of and
gard for material objects, including behaviors trans course of the illness, complexity of the recommen
mitted by way of symbols. "The primary mode of dations, convenience, availability of support system,
transmission of culture is language, which enables and the patient's beliefs.
people to learn, experience, and share their traditions Patient education can improve adherence when the
and customs" (Locke, 1992). In addition, culture can information given includes what behaviors are ex
be expressed or experienced via economic and politi pected, when they should be performed and what to
cal practices, art, and religion. Health care and medi do should problems mise. Plans for patient education
cine have their own cultures. To meet the needs of sessions should strive to remove or avoid barriers to
culturally diverse populations and engage in positive, patient adherence. These efforts include simplifying
productive relationships, physical therapists need to and individualizing treatment regimens, fostering col
operate from a framework of cross-cultural under laborative teacher-learner relationships, enlisting
standing. This understanding and knowledge can then family support, making use of interdisciplinary and
be reflected in patient education efforts. community resources, and providing continuity of
For example, in a large, urban, acute-care hospital care (Meichenbaum and Turk, 1987). By using an ap
two physical therapy staff members were working to proach that integrates these efforts, the physical ther
gether to treat an elderly Jewish woman who was apist can optimize patient adherence to the prescribed
critically ill. The clinicians worked carefully to repo physical therapy program.
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26 Patient Education 463
INTERDISCIPLINARY CONSIDERATIONS
Health-related organizations can also be rich re
AND RESOURCES
sources for patient education information. The Amer
The interdisciplinary health-care team has evolved as ican Heart Association and the American Lung Asso
the complexity and amount of available medical ciation, for example, have many cardiopulmonary
treatments and information has grown. Physical ther materials available to health-care providers for little
apists are trained to function as part of an interdisci or no cost. State public health and local community
plinary team and are respohsible for learning the service agencies may also be sources for printed or
areas of responsibility and expertise covered by each audiovisual materials. The Health and Human Ser
member of their team. The team often consists of li vices Department of the Federal government has nu
censed and nonlicensed health-care providers and merous divisions addressing health education. Cata
may include any or all of the following: logs listing these publications can be obtained from
Physician the Federal Consumer Information Center, Pueblo,
Nurse Colorado 81009.
Physical therapist Community organizations such as YMCA, YWCA,
Occupational therapist and the American Red Cross offer a wealth of health
Exercise physiologist education materials and classes. Many of these agen
Dietician cies also have catalogs of their educational offerings,
Laboratory technologist which can be obtained by telephoning their local of
Pharmacist fices. Local public, medical, and hospital libraries are
• Social worker also useful for seeking out available health-education
• Chaplain or pastoral care associate materials. Many Chambers of Commerce keep lists of
• Clinical psychologist local support groups or clubs, such as Breather's Club
• Speech therapist or Heartbeats. Regional state colleges or universities
• Vocational rehabilitation counselor have departments dedicated to health education and
• Home-care personnel may have cardiopulmonary materials to share.
All of the above providers may not be present on
every team, but their services should be available for
SUMMARY
patients who need them. By understanding what ser
vices and patient education material are provided by This chapter defined patient education and described
each discipline, the physical therapist can reinforce selected learning theories as they relate to cardiopul
previously presented concepts and avoid giving con monary patient education. The evaluation of the pa
flicting information. This also allows the physical tient's learning needs was emphasized and the advan
therapist to make referrals to the appropriate disci tages and disadvantages of a variety of educational
pline when other knowledge deficits are identified. methods were discussed. The role of the teacher-learner
Interdisciplinary team members can also provide relationship and patient adherence were explained in
the physical therapist with important patient feedback reference to the determination of patient education and
and information. Teaching methods found to be suc treatment effectiveness. Finally, interdisciplinary
cessful with a given patient by the nurse, for exam health-care team interactions and resources for patient
ple, could be communicated to the physical therapist. education materials were considered.
The therapist can then use similar methods with that
patient for physical therapy education objectives.
REVIEW QUESTIONS
Communication between team members is enhanced
by regular team meetings or rounds and by having a I. Discuss the benefits of patient education, includ
central location to document completed patient edu ing impact on health care costs and patient's re
cation experiences (i.e., the medical record). sponse to treatment.
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464 PART III Cardiopulmonary Physical Therapy Interventions
2. Define the overall obj ective of patient education Liedekerken, P.e., Jonkers, R., DcHaes. W.F., Kok, G.1., & Saan,
J. (Eds.) (1990). Effecti veness of healrh education: review alld
and discuss the potential barriers to learning and
analysis. Assen, Netherlands: Van GorcllJn.
ways to minimize them.
Locke, D.e. (1992). Increasing multicultural IJIlderstandillg: a
3. Explain the rationale for patient education using comp rehensive lIIodel. Newberry Park: Sage Publications.
concepts of adult learning theories or models. Locke, D.C. (1986). Cross-cultural counseling issues. In A.J.
4. Describe the most important aspect of planning Palmo & W.J. Weikel et al (Eds.), Foundations of Ille II ta I
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26 Patient Education 465
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PART IV
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Acute Medical Conditions
Elizabeth Dean
Willy E. Hammon
Lyn Hobson
INTRODUCTION
circulation to effect cardiac output and tissue perfu
The purpose of this chapter is to review the manage sion (Dantzker, 1983; Dantzker, 1988; Scharf and
ment of primary cardiopulmonary dysfunction sec Cassidy, 1989; Wasserman and Whipp, 1975). Thus
ondary to other medical conditions. Several types of impairment of one organ inevitably has implications
medical conditions are presented to illustrate the prin for the function of the other organ. In addition, threat
ciples and basis for cardiopulmonary physical therapy to or impairment of oxygen transport has implications
in their management. These principles serve as a for all other organ systems, thus a multisystem ap
guide to problem solving when the practitioner is con proach is essential (see Chapters I and 5). The pri
fronted with pathologies that are not presented. Al mary pulmonary conditions that are presented include
though conditions are usually classified as either pri atelectasis, pneumonia, bronchitis, bronchiolitis, alve
mary lung disease or primary cardiovascular disease, olitis, alveolar proteinosis, acute exacerbations of
the heart and lungs work synergistically to effect gas chronic airflow limitation, asthma, cystic fibrosis, in
exchange and in series with the peripheral vascular terstitial pulmonary fibrosis, and tuberculosis. For fur
469
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470 PART IV Guidelines for the Delivery or Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
ther epidemiological and pathophysiological detail on have reduced lung volumes and are prone to breath
these conditions refer to Bates (1989), the Epidemio ing at low lung volumes and microalelectasis, requir
logical Standardization Project of the American Tho ing prophylactic measures to avoid significant effects
racic Society (1989), Luce (1986), Murray and Nadel of atelectasis on oxygen transport and gas exchange.
(I 988a), Murray and Nadel (1988b), and West (1987). When the conditions for normal lung inflation are re
The primary cardiovascular conditions presented in moved, alveolar collapse occurs instantaneously.
clude hypertension, medically stable angina, and un Microatelectasis is associated with reduced lung
complicated myocardial infarction. For further details compliance because of reduced lung expansion. Me
on these condi tions refer to Goldberger (1990), chanically ventilated patients are prone to microat
Sokolow, McIlroy, and Cheitlin (1990), and Under electasis because the normal mechanics of breathing
hill, Woods, Froelicher, and Halpenny (1989). are violated. In part, this may be explained by re
Treatment principles are presented that are not in stricted mobility, recumbency, and reduced arousal,
tended to be a treatment prescription for a particular in addition to reduced functional residual capacity
patient. The treatment priorities are presented based (FRC). Positive end-expiratory pressure (PEEP) is
on the underlying pathology. However, without dis routinely added to minimize these effects. High ven
cussion of a specific patient and knowledge of other tilator system pressure is required to counter reduced
significant factors (i.e., the effects of restricted mobil lung compliance, which indicates that atelectatic lung
ity, recumbency, and the effects of extrinsic and in tissue it not readily reexpandible.
trinsic factors) (Chapter 16), the specific parameters Microatelectasis is not detected readily with chest
of the treatment prescription cannot be established. x-ray but is on the basis of clinical findings. Nonethe
Integration of this information is essential for treat less, microatelectasis can be anticipated in every ill
ment to be specific and maximally efficacious. For and hospitalized patient whose normal respiratory me
specific examples of patient treatment prescriptions chanics are disrupted, and particularly, in recumbent,
refer to the companion text Clinical case studies in relatively immobile patients. These effects are further
cardiopulmonary physical therapy. exacerbated in older patients, patients who are over
weight, have abdominal masses, spinal deformities, or
chest wall asymmetry, smokers, and sedated patients.
Atelectasis
Commensurate with its distribution, atelectasis
Pathophysiology and medical management
presents with reduced chest wall movement and re
A t e l e c t a s i s refers to p a r tial collapse of lung duced breath sounds over the involved area. A chest
parenchyma. The pathophysiological mechanisms x-ray shows increased density over the involved areas
contributing to atelectasis are multiple (see box on with a shift of the trachea and mediastinum toward
p. 471). These mechanisms include physical compres the collapsed lung tissue. The patient may be tachyp
sion of the lung tissue (e.g., resulting from increased neic and cyanotic because of shunting. Segmental at
pleural fluid, pus, pneumothorax, or adjacent areas of electasis results from significant progression of mi
lung collapse) or from an obstructed airway (e.g., se croatelectasis and by obstruction of airways with
cretions or tumor) with subsequent reabsorption of resorption of gas in the distal lung units of a bron
oxygen from the trapped air by the pulmonary capil chopulmonary segment or lobe.
laries resulting in a collapse of the lung tissue distal to The ventilator-dependent patient is predisposed to
the obstruction (i.e., reabsorption atelectasis). developing atelectasis because of an unnatural, mo
There are two primary forms of atelectasis-mi notonous breathing pattern, restricted movement, and
croatelectasis and segmental and lobar atelectasis. abnormal and prolonged recumbent body positions.
Microatelectasis is characterized by a diffuse area of These factors contribute to reduced mucociliary trans
lung units that are perfused but not ventilated, hence, port, abnormal distribution of pulmonary mucus, and
right-to-Ieft shunt. III and hospitalized patients who the accumulation of mucus in the dependent lung
are deprived of being regularly upright and moving fields. Furthermore, production of mucus may be in
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Pathophysiological Mechanisms Contributing to Atelectasis
Central Mechanisms
Breathing at low lung volumes (e.g., when in pain or after certain medications)
Central disruption of breathing centers controlling normal periodic and rhythmic breathing pattern
Extramural Mechanisms
Phrenic nerve inhibition (e.g., secondary to upper abdominal or cardiovascular thoracic surgery)
Compression of lung parenchyma secondary to pleural tluid accumulation, blood, plasma. and pus
Mechanical ventilation
Mural Mechanisms
Intramural Mechanisms
Mucolls plug
Space.Occupying Lesions
Foreign-bouy aspiration
Intlammation
Other Factors
Increased compliance and dynamic airway compression secondary to age-related changes to the lung
Increaseu timc constants because of increased airway resistance. reduced compliance. or both
Splinting or casting of chest wall restricting normal three-dimensional chest wall movement
Oxygen
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472 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
creased due to tracheostomy or the presence of an these interventions distributes ventilation more uni
endotracheal tube. Mucociliary clearance is further formly rather than directing gas to already open alve
compromised by reduced ciliary activity resulting oli, which will overdistend these units. The distribu
from high concentrations of oxygen, medication, tion of ventilation is primarily altered by body
and loss of an effective cough because of an artifi positioning and not by deep breathing (Roussos, Fix
cial airway. ley, Geriest, Cosio, Kelly, Martin, and Engely, 1977).
The effect of atelectasis on oxygen transport re Sustained maximal inspiratory efforts may augment
flects its type and distribution. Hypoxemia, right to alveolar ventilation, however, the parameters for such
left shunt, reduced lung compliance, and increased efforts to be maximally therapeutic have not been
work of breathing are common clinical manifesta studied in detail.
tions. An increased temperature reflects an inflamma If impaired mucociliary transport or excessive secre
tory or infective process and not atelectasis per se. tions are obstl1lcting airways and contributing to atelec
tasis, mobilization of pulmonary secretions is the goal
Principles of physical therapy management that may be affected by mobilization and a "stir-up reg
Because it can develop instantaneously when respira imen" (Dripps and Waters, 1941; Ross and Dean,
tory mechanics are disrupted, microatelectasis should 1989). In addition, postural drainage coordinated with
be anticipated and prevented. Those factors that con breathing control and coughing maneuvers can facili
tribute to atelectasis for a given patient are countered tate airway clearance. The addition of modified manual
accordingly with aggressive prophylactic manage techniques may be indicated in some patients.
ment (see the box on p. 471).
Once developed, however, atelectasis is treated
Pneumonia
aggressively. Treatment is primarily directed at re
Pathophysiology and medical management
versing the underlying contributing mechanisms
whenever possible (Don, Craig, Wahba, and Couture, Pneumonia is a common cause of morbidity and mor
1971; Glaister, 1967; Leblanc Ruff, and Milic-Emili, tality in the hospitalized patient, particularly in very
1970; Lewis, 1980; Ray, Yost, Moallem, Sanoudos, young and very old patients (Bartelett and Gorbach,
Villamena, and Paredes, 1974; Remolina, Khan, San 1976). Comparable wi th other systemic infections,
tiago, and Edelman, 1981). For example, atelectasis pneumonia results when the normal defense mecha
resulting from restricted mobility is remediated with nisms of the respiratory system fail to adequately
mobilization. Atelectasis resulting from prolonged protect the lungs from infection.
static positioning and monotonous tidal ventilation is Air inspired through the nasal passages is cleansed
managed with mobilization, manipulating body posi of particulate matter by filtration (cilia sweep it to the
tion to increase alveolar volume of the atelectatic nasopharynx); impaction (irregular contour of the
area, manipulating body position to optimize alveolar chamber causes particles to rain out); swelling of hy
ventilation, or some combination of these interven groscopic droplet nuclei, which are either filtered or
tions. Atelectasis arising from reduced arousal is become impacted; and defense factors located in the
managed by reducing the causative factors contribut mucous blanket, such as immunoglobulins (IgA),
ing to reduced arousal coupled with frequent sessions Iysozymes, polymorphonuclear leukocytes, and spe
of mobilization and the upright position to increase cific antibodies. Particles that escape one of these de
arousal, promote greater tidal volumes and alveolar fense mechanisms in the nasopharynx may be pre
ventilation, increase zone 2 (area of optimal ventila vented from entering the lower airways of the larynx.
tion and perfusion matching), increase FRC, and min The mucosa of the larynx is sensitive to chemical irri
imize closing volume. tation or mechanical deformation and responds to this
Breathing control and coughing maneuvers aug stimuli by producing a cough. The high velocities
ment the cardiopulmonary physiological effects of created by the cough are sufficient to clear several
mobilization and body positioning. Coordinating branches of the tracheobronchial tree of particulate
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27 Acute Medical Conditions 473
matter. The cough reflex is frequently absent or de common cold. The ciliated cells of the respiratory
pressed in hosts who are unconscious from drug tract are the most frequent site of infection. They be
overdose, epilepsy, alcohol ingestion, or head injury. come paralyzed and degenerate with areas of necrosis
Patients with artificial airways are more susceptible and desquamation. The mucociliary blanket becomes
to infection because all the previously mentioned de interrupted because destruction of the cilia leaves a
fense mechanisms are bypassed, causing organisms thin layer of nonciliated basal replacement cells. In
to be deposited directly in the lower airways. In the flammatory responses cause exudation of fluid and
lower airways the cough mechanism is rendered inef erythrocytes in both the alveolar septae and airways.
fective by endotracheal tubes, which prevent approxi Congestion and edema become predominant with the
mation of the vocal cords, and by tracheostomy formation of intraalveolar hyaline membranes. These
tubes, which cause air to bypass the cords altogether. changes in the normal mucosal structure and cilia
The trachea and the tracheobronchial tree to the make involved areas of the lung susceptible to super
level of the respiratory bronchioles are protected by imposed bacterial infections. This is the most com
the cough reflex, filtration (again by cilia which mon complication seen in viral infections and is usu
transport particles to the pharynx), impaction, and ally responsible for the fatalities that occur.
chemical factors (IgA). Below the level of the respi The patient with viral pneumonia presents with
ratory bronchioles, the cough reflex is ineffective, fever, dyspnea, loss of appetite, and a persistent non
and filtration and transportation of particles by cilia productive cough. On auscultation, normal breath
cannot occur because cilia are absent. The alveolar sounds are heard throughout both lung fields with
macrophages play an important role in protecting scattered inspiratory crackles. X-ray changes range
these airways from particulate matter. Macrophages from minor infiltrates to severe bilateral involvement.
ingest organisms and transport them to the lymphatic Consolidation and pleural effusions occur less fre
system or higher in the tracheobronchial tree to quently. Secondary bacterial infections occur fre
where cilia can sweep them to the pharynx. This quently, causing patients to develop productive
process of phagocytosis can be slowed or stopped by coughs.
hypoxia, alcohol ingestion, air pollutants, corticos Influenza may lead to viral pneumonia in I % to
teroids, immunosuppressant agents, starvation, ciga 5% of cases. Influenza includes acute viral respira
rette smoke, and oxygen. Particulate matter may also tory tract infection, characterized by a sudden onset
be removed from the airways below the level of the of headache, myalgia, and fever. The route of infec
respiratory bronchioles by postural drainage. tion is by inhalation of airborne particles from an in
fected person. The incubation period is 24 to 72
hours.
Routes of Infection
Pulmonary lesions include edema of the respira
A host who has impaired or ineffective defense tory epithelium with necrosis and hemorrhage. At the
mechanisms of the respiratory tract becomes suscep alveolar level, interstitial edema, proliferation of type
tible to a variety of organisms. The major routes of I cells, hemorrhage, and an increased number of
infection include airborne organisms, circulation, macrophages are seen. In patients with pneumonia,
contiguous infection, and aspiration. secondary bacterial infections are frequent and are
the cause of most fatalities.
Medical treatment of viral infections is supportive
CLASSIFICATION OF PNEUMONIA
and preventative. Patients should receive vaccines
Viral Pneumonias
whenever possible to buildup antibodies against spe
Most respiratory viral infections are contracted by cific viruses. Once the patient has contracted the or
droplets from the respiratory tracts of infected per ganism, treatment becomes supportive, with rest, sali
sons. These viruses are responsible for interstitial c y lale s , and high f luid intake b e i n g the m a i n
pneumonias, tracheobronchitis, bronchiolitis, and the treatment priorities. Patients w h o become more
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474 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
acutely ill with viral pneumonia should be on a vigor illness characterized by fever, tachypnea, dyspnea, hy
ous preventative program to lessen the possibility of poxemia, tachycardia, and a cough producing bloody
bacterial infection. or purulent sputum. The clinical findings depend on
Recovery also depends on good nutrition, hydra the organism involved and the extent of the pneumo
tion, sleep, rest, and reduced stress. nia in the lungs. The infective process may cease with
the use of chemotherapeutic agents, aerosols, and
Principles of physical therapy management
physical therapy, or it may spread to contiguous areas,
Patients may respond to mobilization coordinated causing pleural effusions and empyemas.
with breathing control exercises and positional rota Bacterial pneumonias can occur as either primary
tion for enhancing alveolar ventilation, mucociliary or secondary infections. Primary pneumonias arise in
transport, and gas exchange overall (Orlava, 1959). otherwise healthy individuals and are usually pneumo
Extreme body positions may enhance alveolar volume coccal in origin. Secondary pneumonias occur when
and ventilation and ventilation and perfusion match the patient's defense system becomes ineffective.
ing (Dean, 1985; Douglas, Rehder, Beynen, Sessler, Pneumococcal pneumonia is caused by pneumo
and Marsh, 1977; Grimby, 1974; Piehl and Brown, coccal bacteria, a gram-positive organism. It occurs
1976). Vigorous treatment should be initiated at the most frequently in the winter months among adults
first sign of a superimposed bacterial infection, which between 15 and 40 years of age with a predilection for
is often accompanied by a productive cough. At this males. Patients present clinically with an abrupt onset
time, the appropriate devices should be prescribed of illness characterized by fever, cough, purulent or
(e.g., ultrasonic or medication nebulizers to loosen se rust-colored sputum, and pleuritic chest pain over the
cretions). Postural drainage may be indicated in addi affected lung field. Physical examination may reveal
tion to mobilization for airway clearance. Treatments, decreased expansion of the chest over the affected
particularly mobilization, need to be paced to mini area and muscle splinting. On auscultation, there may
mize unduly tiring the patient or increasing oxygen be bronchial breath sounds (indicating consolidation),
demand beyond the patient's capacity to adequately decreased or absent breath sounds, and wheezes or
deliver oxygen. Increasing oxygen demands exces crackles over the affected lung. Chest x-rays may
sively may compromise the patient's gas exchange. show infiltrates, consolidation, or atelectasis.
Patient education is also fundamental to the treatment There are four stages associated with bacterial in
that is to be instituted between treatments (i.e., mobi fection of lung tissue-engorgement, red hepatiza
lization and positional rotation coordinated with tion, gray hepatization, and resolution. The engorge
breathing control and coughing maneuvers). ment stage occurs within the first few days of
The focus of cardiopulmonary physical therapy in infection and is characterized by vascular engorge
the management of viral pneumonia is to augment ment, serous exudation, and evidence of bacteria col
alveolar ventilation, increase perfusion, increase dif onization. Red hepatization occurs within 2 to 4 days
fusion, and improve ventilation and perfusion match as a result of diapedesis of the red blood cells. The
ing, thereby reducing the threat to oxygen transport alveoli are full of polymorphonuclear leukocytes, fib
and gas exchange. Treatments are prescribed to opti rin, and red blood cells. The organism continues to
mize oxygen transport and gas exchange and to mini mUltiply within the fluid exudate. Areas of consolida
mize fatigue and lethargy. tion become evident. Gr<!y hepatization occurs within
4 to 8 days and is characterized by evidence of abun
dant fibrin, decreased polymorphonuclear leukocytes,
Bacterial Pneumonia
and dead bacteria. Consolidation continues to be a
Bacterial pneumonia causes the largest number of problem in this stage. Resolution occurs after 8 days
deaths per year by an infective agent and is the fifth as areas of consolidation begin to resolve. Many
most common cause of all deaths in North America. macrophages are seen and evidence of enzymatic di
The patient presents with an abrupt onset of a severe gestion of exudate is present. The affected tissue be
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27 Acute Medical Conditions 475
comes softer with large amounts of grayish-red fluid is the same as that for pneumococcal pneumonia.
present within the alveol i. This process continues for Hemo philus inJluenzae pneumonia is caused by a
2 to 3 weeks with the lung gradually assuming a gram-negative organism and occurs primarily in chil
more normal appearance. dren as bronchiolitis and in adults who have chronic
Pleural involvement occurs frequently, with the bronchitis. The clinical picture is the same as for the
pleural spaces filling with the same type of fluid other bacterial pneumonias, with numerous areas of
seen within the alveoli. Resolution is much slower infiltration evident on x-ray. On auscultation, breath
because there are few surfaces available for phago sounds are generally good, with crackles heard at the
cytosis. Complications that may occur in patients end of inspiration. Treatment of this pneumonia in
with pneumococcal involvement include empyema, cludes chemotherapeutic agents (ampicill in), oxygen,
superinfections (occur when large numbers of new ultrasonic nebulization, and physical therapy.
organisms invade the lung), abscesses, atelectasis, Other gram-negative organisms causing pneumo
and delayed resolution (defined as taking more than nia include Esch erichia co li and Pseudomo n as
4 weeks to resolve). aeruginosa. They are seen most frequently in patients
Treatment of pneumococcal pneumonia involves with underlying disease, especially pulmonary dis
the use of chemotherapeutic agents, with penicillin ease, or in those who are debilitated. They are fre
being the antibiotic of choice. If the patient is allergic q uently the cause of superinfections in individuals
to penicillin, erythromycin or lincomycin is used. who have received massive doses of broad-spectrum
Thoracentesis is performed when pleural fluid is pre antibiotics. Clinically these patients present with
sent. The patient should also receive ultrasonic nebu cough, fever, and dyspnea. On auscultation, crackles,
lization and physical therapy. Supplemental oxygen bronchial breathing, and diminished or absent breath
therapy may be indicated. sounds can be noted. X-ray changes frequently show
Staphlococcal pneumonia is caused by a gram bibasilar infiltrates, with the amount of involvement
positive organism. It rarely occurs in the healthy being widely variable. As for other bacterial pneumo
adult but is a frequent cause of pneumonia in chil nias, treatment includes chemotherapeutic agents, ul
dren, infants, and patients with chronic lung diseases, trasonic nebulization, and physical therapy.
especially carcinoma, tuberculosis, and cystic fibro
Principles of physical therapy management
sis. Clinically, the patient presents with the same pic
ture as the patient with pneumococcal pneumonia. The goals of management of bacterial pneumonia in
There are some differences in the chest x-ray (e.g., clude reversing alveolar hypoventilation, increasing
patchy areas of infiltrate). Consolidation occurs infre perfusion, reducing right-to-Ieft shunt, increasing
quently in this type of pneumonia. Pleural effusions, ventilation and perfusion matching, minimizing the
empyema, abscesses, bronchopleural fistulas, and effects of increased mucous production, and optimiz
pneumatoceles (subpleural cyst-like structures) occur ing lymphatic drainage. Bacterial pneumonia is fre
frequently. Treatment includes chemotherapeutic quently associated with increased mucous produc
agents, rest, increased fluid intake, ultrasonic nebu tion. With respect to airway clearance, management
lization or medication nebulizers, and aggressive focuses on augmenting mucociliary clearance overall,
physical therapy. reducing excess mucous accumulation, and reducing
Streptococcal pneumonia is caused by a gram-posi mucous stasis. Patients are often mobile and should
tive organism, Streptococcus pyogenes. It occurs most be encouraged to be so to promote mucociliary trans
frequently in very young, very old, and debilitated pa port and enhance lymphatic drainage (Dean and
tients. The clinical picture is very similar to that of Ross, I 992a; Orlava, 1959; Wolff, Dolovich, Obmin
staphlococcal pneumonia. Again consolidation is rare ski, and Newhouse, 1977). However, the oxygen de
and chest x-rays usually show one or more areas of mands of mobilization and exercise should be well
patchy infiltrates. Complications are rare but empyema within the patient's capacity to delivery oxygen.
does occasionally occur. Treatment for this organism These interventions should be prescribed to avoid
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476 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
jeopardizing this balance and unduly fatiguing the pa term, the bone marrow produces more red blood
tient (Dean and Ross, I992b). Deep breathing and ef cells, leading to polycythemia. The work of the heart
fective coughing are singularly important maneuvers is increased due to increased blood viscosity. Long
for clearing airways with special attention to the avoid term hypoxemia leads to increased pulmonary artery
ance of airway closure (Bennett et aI., 1990). Prescrip pressure and right ventricular hypertrophy.
tive body positioning can be used to optimize ventila Patients with chronic bronchitis have tenacious,
tion and perfusion matching (Clauss, Scalabrini, Ray purulent sputum that is difficult to expectorate. In an
and Reed, 1968; Douglas et aI., 1977; Hietpas, Roth exacerbation, usually because of inflammation, infec
and Jensen, 1974; Hasani, Pavia, Agnew, and Clarke, tion, or both, they produce even more sputum, which
199 I; Ross and Dean, 1992; Ross, Dean, and Abboud, tends to be retained and stagnate. Retained secretions
I992b; Zack, Pontoppidan, and Kazemi, 1974). obstruct airways and thus air flow, and reduce alveo
lar volume. The resulting venti lation and perfusion
inequality increases hypoxemia, CO2 retention, ac
Acute Exacerbation of Chronic Bronchitis
cessory muscle use, melabolic demand, and breathing
Pathophysiology and medical management
rate. Pao2 is further reduced and Paco2 tends to in
Chronic bronchitis is a disease characterized by a crease. Hypoxemia and acidemia increase pulmonary
cough producing sputum for at least 3 months and for vasoconstriction, which increases pulmonary artery
2 consecutive years. Pathological changes include an pressure and predisposes the patient to right heart
increase in the size of the tracheobronchial mucous failure (cor pulmonale) over time.
glands (increased Reid index) and goblet cell hyper A patient having an acute exacerbation of chronic
plasia. Mucous cell metaplasia of bronchial epithe bronchitis tends to have the following characteristics:
lium results in a decreased number of cilia. Ciliary (I) The patient is often stocky in build and dusky in
dysfunction and disruption of the continuity of the color. (2) The patient exhibits significant use of acces
mucous blanket are common. In the peripheral air sory muscles of respiration and has audible wheezing
ways, bronchiolitis, bronchiolar narrowing, and in or wheezing that is audible on auscultation. (3) Inter
creased amounts of mucus are observed. costal or sternal retraction of the chest wall may be
Chronic bronchitis results from long-term irrita noted. (4) Edema in the extremities, particularly
tion of the tracheobronchial tree. The most common around the ankles, and neck vein distention reflect de
cause of irritation is cigarette smoking. Inhaled compensated right heart failure. (5) The patient may
smoke stimulates the goblet cells and mucous glands report that breathing difficulty began with increased
to secrete excessive mucus. Smoke also inhibits cil amounts of secretions (with a change in their normal
iary action. The hypersecretion of mucus and ciliary color), which is often difficult to expectorate, and in
damage and dyskinesis lead to impaired mucous creased cough productivity. (6) Pao2 is reduced, Paco2
transport and a chronic productive cough. The fact increased, and pH reduced.
that smokers secrete an abnormal amount of mucus Pulmonary function tests indicate reduced vital
increases the risk of respiratory infections and in capacity, FEY!, maximum voluntary ventilation,
creases the length of the recovery time from these in and diffusing capacity and increased FRC and resid
fections. Although smoking is the most common ual volume.
cause of chronic bronchitis, other factors that have
Principles of physical therapy management
been implicated are air pollution, certain occupational
environments, and recurrent bronchial infections. During an exacerbation requiring hospitalization,
Patients with chronic bronchitis have been referred these patients are usually treated with intravenous
to as blue bloaters because of a tendency to have a fluids, antibiotics, bronchodilators, and low-flow
dusky appearance and be stocky in build. Although oxygen. Diuretics and digitalis are often given to treat
many patients have a high Pac02, the pH is normal right heart failure. Airway clearance interventions are
ized by renal retention of bicarbonate. Over the long selected (i.e., mobilization, body positioning, and
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27 Acute Medical Conditions 477
postural drainage). These interventions are coordi thickened basement membrane. The obstruction as
nated with breathing control and coughing maneuvers sociated with bronchiolitis leads to ventilation and
to facilitate secretion removal and optimize coughing perfusion abnormalities and diffusion defect. Clini
and expectoration, while minimizing dynamic airway cally, the patient presents with a productive cough.
compression and alveolar collapse. During recovery, Obliterative bronchiolitis has been reported to be
exercise with supplemental oxygen may also benefit the most significant long-term complication o f
the patient. It is important for these patients to avoid heart-l u n g t r a n s p l a n t a t i o n (B u r k e , Gla n v i lle,
bronchial irritants (e.g., cigarette smoking, second Theodore, and Robin, 1987).
hand smoke, and air pollutants), and to be adequately Medical management is directed at inflammation
hydrated to thin secretions to facilitate mucociliary control with pharmacological agents, fluid manage
transport and expectoration. ment, and oxygen administration if necessary. Pre
Patients with chronic bronchitis can benefit from vention of infection is a priority.
a comprehensive rehabilitation program designed
Principles of physical therapy management
specifically for patients with chronic pulmonary
disease (Murray, 1993; Oldenburg, Dolovich, The principal pathophysiological defects include ven
Montgomery, and Newhouse, 1979). Specific de tilation and pelfusion inequality and diffusion defect.
tails of exercise prescription in the management of These defects result from secretions produced by in
chronic lung disease and of a comprehensive pul flammation and increased mucous production and
monary rehabilitation program are described in from atelectasis of adjacent alveoli. Physical therapy
Chapter 23. treatment should promote mucociliary transpol1 and
the removal of secretions and mucus to central air
ways, promote alveolar expansion and ventilation,
Bronchiolitis
optimize ventilation and pelfusion matching and gas
Pathophysiology and medical management
exchange, and reduce the risk of infection.
Bronchiolitis results from peripheral airway inflam Bronchiol i tis is primari Iy, al though not exclu
mation. In severe cases the exudate in the peripheral sively, a childhood condition. The effects of inflam
airways becomes organized into a connective tissue mation and obstruction in small children are always
plug extending into the peripheral airway. The in serious because the anatomical and physiological
flammatory process resembles that in other tissues components of the cardiopulmonary s ystem are
(i.e., an inflammatory stage followed by a prolifera smaller, respiratory muscle tone is less well devel
tive healing stage). Such inflammation is associated oped, the anatomical configuration of the chest wall
with vascular congestion, increased vascular perme is cylindrical, breathing is less efficient until after the
ability, formation of exudate, mucous hypersecre age of 2, spontaneous movement and body position
tion, and shedding of the epithelium. Fluid is exu ing are more restricted (infants in particular spend
dated o u t of the circulation onto the alveola r more time in nonupright positions), and children are
surfaces replacing the surfactant. This in turn in at greater risk of infection (see Chapter 35).
creases the surface tension and promotes airway clo
sure. The secretion production associated with air
Alveolitis
way irritants and inflammation results from the
Pathophysiology and medical management
excess mucous production in combination with the
inflammatory exudate consisting of fluid protein Bronchioalveolitis is another inflammatory disorder
and cells of the exudate. Airway obstruction results of the peripheral airways that is often associated
if these substances are not removed. The airway ep with an extrinsic allergic reaction. Comparable with
ithelium has the capacity to repair and reline the bronchiolitis, alveolitis is prevalent in young chil
lumen. A rapid turnover of cells may contribute to dren. In adults, chronic alveolitis may be a precursor
cell sloughing and further airway obstruction and a to interstitial pulmonary fibrosis. Acute bouts of
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478 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
alveolitis are reversible, however, chronic inflam position with the lung to be lavaged downward. The
mation can produce airway narrowing secondary to Carlen's tube enables the patient to be ventilated by
fibrosis in the alveolar wall and complete obstruc the uppermost lung while the lower lung is care
tion of the airway by organization of the exudate. fully filled with saline to FRC. Then an additional
Chronic inflammation can lead to permanent irre 300 to 500 ml of saline is alternately allowed to run
versible parenchymal changes and chronic restric into and out of the lung by gravitational flow. As
tive lung disease. the saline flows out, manual percussion over the af
fected lung being lavaged has been reported to in
Principles of physical therapy management c r e a s e t h e a m o u n t of p r o t e i n a c e o u s m a t e r i a l
The principles of physical therapy management are washed f r o m t h e lung (see Figure 4-11, p . 86).
comparable with that for the management of bronchi (Hammon, 1987).
olitis. Principles of the management of cardiopul
monary dysfunction in children are presented in
Acute Exacerbation of Chronic Airflow limitation
Chapter 35. Because children and infants in particular
are physically immature, the principles of manage
PathophYSiology and medical management
ment are different from those for adults. Emphysema. There are two principal types of em
physema-centrilobular and panlobular. BOlh types
may coexist, however, centrilobular emphysema is
Alveolar Proteinosis
20 times more common than panlobular emphy
Pathophysiology and medical management sema. Centrilobular is characterized by destruction
Alveolar proteinosis is a condition of unknown etiol of respiratory bronchioles (see Figure 4-1, p. 73), as
ogy, characterized by alveoli filled with lipid-rich well as edema, inflammation, and thickened bron
proteinaceous material and no abnormalities in the chiolar walls. These changes are more common and
alveolar wall, interstitial spaces, conducting airways, more marked in the upper portions of the lungs.
or pleural surfaces. Most often it is found in men be This form of emphysema is found more often in
tween 30 and 50 years of age, although it has been re men than in women, is rare in nonsmokers, and is
ported in both men and women of all ages. common among patients with chronic bronchitis.
The most common symptoms are progressive dys Panlobular emphysema is characterized by destruc
pnea and weight loss, with cough, hemoptysis, and tive enlargement of the alveoli distal to the terminal
chest pain reported less frequently. Chest x-rays re bronchioles (see Figure 4-1, p. 73). This type of em
veal diffuse bilateral (commonly perihilar) opacities physema is also found in patients who have an antit
(see Figure 4-10, p. 86). Physical findings include rypsin deficiency. Airway obstruction in these indi
fine inspiratory crackles, dullness to percussion and, viduals is caused by loss of elastic recoil or radial
in the later stages, cyanosis and clubbing. Pulmonary traction on the bronchioles. When individuals with
function studies usually show decreased vital capac normal lungs inhale, the airways are stretched open
ity, FRC, and diffusing capacity. Arterial blood gases by the enlarging elastic lung, and during exhalation
indicate a low P02, especially during exercise, with the airways are narrowed due to the decreasing
often nonnal Pe02 and pH. stretch of the lung. However, the lungs of patients
with panlobular emphysema have decreased elastic
Principles of physical therapy management
ity because of disruption and destruction of sur
One treatment for patients with moderate-to-severe rounding alveolar walls. This in turn leaves the
dyspnea on exertion from alveolar proteinosis is bronchioles unsupported and vulnerable to collapse
bronchopulmonary lavage. The patient is taken to during exhalation. This form of emphysema can be
the operating room. After general anesthesia and local or diffuse. Lesions are more common in the
placement of a Carlen's tube (which isolates each bases than the apices and tend to be more prevalent
lung), the patient is turned in the lateral decubitus in older people.
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27 Acute Medical Conditions 479
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480 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
Hypoxemia leads to hypoxic pulmonary vasocon patients with a FEY1 less than 0.75 L. However, if
striction, which shunts blood from underventilated to these flow rates are found in patients with complica
better-ventilated areas of the lung. The afterload tions of resting tachycardia, chronic hypercapnia, and a
against which the right heart has to pump is in severely impaired diffusing capacity, the survival rates
creased. This elevates the pulmonary artery blood should be reduced by 25%. Other factors that have
pressure (i.e., pulmonary hypertension). Over the been associated with a poor prognosis are cor pul
long term, the right heart hypertrophies to work monale, weight loss, radiological evidence of emphy
against this increased resistance and eventually may sema, a dyspneic onset, polycythemia, and Hoover's
fail (cor pulmonale). Heart enlargement secondary to sign (inward movement of the ribs on inspiration).
any cause alters the electrical conduction pattern ef The most frequent causes of death in patients with
fecting electromechanical coupling and cardiac out airflow limitation are congestive heart failure (sec
put. The altered size and heart position within the ondary to cor pulmonale), respiratory failure, pneu
chest wal.l can be detected by ECG changes. monia, bronchiolitis, and pulmonary embolism.
Treatment of emphysema that requires hospitaliza As emphysema becomes chronic, the hemidi
tion often includes intravenous fluids, antibiotics, and aphragms become more horizontally positioned, plac
low-flow oxygen (Geddes, 1984; Make, 1983). Some ing the muscle fibers at a less efficient position on
patients require bronchodilators, diuretics, and digi their length tension curve (Druz and Sharp, 1982).
talis. Patients with chronic airflow limitation adapt to Breathing when the muscle fibers of respiration are
high Paco2 levels, thus becoming dependent on their mechanicall y disadvantaged increases the work of
hypoxic drives to breathe. Therefore, low flow oxy breathing and therefore energy demands and oxygen
gen is administered to these patients to avoid abolish cost. Respiratory muscle weakness and fatigue are se
ing their drive to breathe. rious complications of chronic lung disease that pre
The etiology of emphysema is uncertain. The inci dispose the patient to respiratory muscle failure
dence of emphysema increases with age. It is most (Rochester and Arora, 1983) (Chapter 4 and 32).
often found in patients with chronic bronchitis and is The net effect of these pathological changes on
significantly more prevalent in smokers than non gas exchange is hypoxemia, hypercapnia, and re
smokers. There appears to be a hereditary factor. Se duced pH consistent with respiratory acidosis. Long
vere panlobular emphysema can develop in patients term respiratory insufficiency leads to chronically
with an alpha-antitrypsin deficiency relatively early impaired oxygen transport and gas exchange. To
in life even though they never smoked. Repeated compensate for hypercapnia, production of bicarbon
lower respiratory tract infections may also play a role ate is increased to buffer retained CO2 (i.e., compen
in the pathology of emphysema. However, the inter sated respiratory acidosis). Red blood cell production
relationship of these and other factors in producing (i.e., polycythemia) is increased to increase the oxy
the condition is still not well understood. gen-carrying capacity of the blood. The negative ef
Chronic bronchitis and emphysema are marked by a fect of polycythemia, however, is increased viscosity
progressive loss of lung function and corresponding of the blood, leading to increased risk of circulatory
cardiac dysfunction. At the end of 5 years, patients stasis, thromboses, and increased work of the heart.
with chronic airflow limitation have a death rate four
Principles of physical therapy management
to five times greater than the normal expected value.
Death rates reported by various studies depend on the The patient with emphysema is prone to pulmonary
methods of selection of patients, types of diagnostic infections and respiratory insufficiency. The clinical
tests, and other criteria. In general the death rates 5 picture is hallmarked by alveolar collapse and de
years after diagnosis are 20% to 55%. The 5-year sur struction, ventilation and perfusion mismatching, and
vival rates based on FEY I have been reported as fol diffusion defect. These defects result in impaired or
lows: 80% in patients with a FEY I greater than 1.2 L, threatened oxygen transport if the physiological com
60% in patients with a FEY L close to 1 L, and 40% for pensations are unable to maintain adequate blood
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27 Acute Medical Conditions 481
gases. Shortness of breath is exacerbated and breath the chest wall by the viscera falling against the un
ing is labored. Increased work of breathing reflects derside of the diaphragm in this position (i.e., vis
airway obstruction and inefficiency of respiratory cerodiaphragmatic breathing) (Barach, 1974). The
mechanics and the respiratory muscles. Because of muscle fibers of the diaphragm are mechanically
long-term airway disease, mucociliary transport is placed in a more favorable position with respect to
disrupted. Therefore, in the presence of a pulmonary their length-tension characteristics. This effect may
infection and increased production of pulmonary se further be augmented in the head-down position in
cretions, secretion removal can be a significant prob some patients (Barach and Beck, 1954). Other pa
lem for the patient. tients, however, cannot tolerate recumbent posi
Specific treatments are prescribed for the patient tions; in fact, respiratory distress may be increased.
based on the specific clinical findings (i.e., the type If optimal treatment outcome has not been achieved
and severity of the cardiopulmonary dysfunction with mobilization and body positioning coordinated
and the presence of infection). Therefore treatments with breathing control and coughing maneuvers,
include mobilization coordinated with breathing conventional physical therapy procedures may offer
control and coughing maneuvers, which are effec additional benefit in some patients (e.g., postural
tive in enhancing alveolar ventilation, mobilizing drainage and manual techniques).
secretions, and in ventilation and perfusion match Because of the tendency toward dynamic airway
ing. Body positioning can be prescribed to alter the compression resulting from the highly compliant air
distribution of ventilation, to aid mucociliary trans ways of emphysema patients, open-glottis coughing
port, and to remove pulmonary secretions. Although maneuvers are indicated. Specific outcome measures
"pure" emphysema is t y p i c a l l y dry, p o s t u r a l are recorded before, during, and after treatment to as
drainage positions can facilitate the removal o f pul sess short- and long-term treatment effects. In addi
monary secretions from specific bronchopulmonary tion, between-treatment treatments are central to
segments if indicated. In any given body position, maximizing overall treatment efficacy. Thus convey
alveolar volume is augmented in the uppermost lung ing information effectively and specifically to the pa
fields and alveolar ventilation is augmented in the tient, nursing staff, and possibly family members is
lowermost lung fields. The type and extent of crucial to achieve an optimal treatment outcome.
pathology will determine the degree of benefit these Comparable with the chronic bronchitis patient, an
physiological effects will have on oxygen transport. exercise program for these patients should be pre
In addition, body positioning is essential to optimize scribed to maximize oxygen transport capacity. Such
respiratory mechanics and enhance pulmonary gas conditioning may reduce the frequency and severity
exchange, thereby reducing the work of breathing of subsequent acute exacerbations. In addition, the
and the work of the heart. The assessment will de patient may benefit from other components of a com
fine the parameters of the treatment prescription that prehensive pulmonary rehabilitation program.
will be effective in relieving the work of breathing
and the work of the heart. This information is essen
Acute Exacerbation of Asthma
tial not only for prescribing beneficial positions but
also for avoiding deleterious positions. A sitting
Pathophysiology and medical management
lean-forward position will assist ventilation sec Asthma is a condition characterized by an increased
ondary to the gravitational effects of the upright po responsiveness of bronchial smooth muscle to vari
sition on cardiopulmonary function. If the arms are ous stimuli and is manifested by widespread narrow
supported, this position stabilizes the upper chest ing of the airways that changes in severity either
wall and rib cage, thereby facilitating inspiration. spontaneously or as a result of treatment (Hogg,
Some patients with horizontal diaphragms and sig 1984; Rees, 1984). During an asthma attack, the
nificant respiratory distress benefit from recumbent lumen of the airways is narrowed or occluded by a
positions in which the diaphragm is elevated within combination of bronchial smooth muscle spasm, in
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482 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
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27 Acute Medical Conditions 483
ferred to as status asthmaticus. This condition consti bronchial lumen, further contributing to the stasis of
tutes a medical emergency, necessitating admission secretions. Thus optimizing the mobilization of secre
to the intensive care unit (see Chapter 32). tions and their removal is a priority even in tile pres
ence of scant secretions. Interventions that optimize
Principles of physical therapy management mucociliary transport are selected to minimize exac
The hallmark of an acute exacerbation of asthma is erbating bronchospasm and further increases in air
an increased responsiveness of airway smooth muscle way resistance.
to various stimuli (bronchospasm) (i.e., reversible air The primary goals in the management of asthma
way obstruction). Although bronchospasm can be a include reducing airway narrowing, improving alveo
feature of chronic bronchitis and emphysema, the pri lar ventilation, reducing the work and energy cost of
mary cause of airway obstruction in these conditions breathing, reducing hypoxemia or minimizing its
results from anatomical and physiological changes threat, and optimizing lung compliance.
that are not usually reversible. Treatment outcome is assessed with indices of
Physical therapy is directed at improving gas ex oxygen transport overall and of the function of the in
change without aggravating bronchospasm and other dividual steps in the pathway (Epstein and Henning,
symptoms and reversing these when possible. Thus 1993). Bedside spirometry, including peak expiratory
promoting more effective and efficient breathing with flow rate, is a sensitive indicator of ensuing compro
relaxed controlled breathing maneuvers and con mise in oxygen transport. Some patients use a peak
trolled unforced coughing maneuvers in optimal body expiratory flow rate meter at home to detect such
positions is a priority. Overall oxygen demand, in changes and as an early indicator of the need for
cluding that associated with an increased work of medical attention.
breathing, needs to be reduced during an exacerba
tion of asthma. This may require reduced activity,
Acute Exacerbation of Cystic Fibrosis
body positioning that improves breathing efficiency,
judicious rest and sleep periods, altered diet or re
Pathophysiology and medical management
stricted diet, adequate hydration, maintaining a ther Cystic fibrosis (CF) is a complex multisystem disor
moneutral environment, rest, reduced arousal, re der transmitted by an autosomal-recessive gene that
duced social interaction and excitement, and reduced affects the exocrine glands (Landau, 1973). CF in
environmental stimulation. Although general relax volves all of the major organ systems in the body
ation does not directly relax bronchial smooth mus and is characterized by increased sweat electrolyte
cle, relaxation will assist breathing control, reduce content, chronic airflow limitation, ventilation inho
arousal and metabolic demands, and promote more mogeneity, and pancreatic insufficiency. Definitive
efficient breath ing. diagnosis of CF includes positive family history,
Airway narrowing and obstruction is a hallmark of clinical symptoms of poor digestion, growth or re
this condition secondary to increased bronchial current pulmonary infection, and, most importantly,
smooth muscle tone and airway edema. Even small a positive sweat chloride test. Survival has increased
amounts of pulmonary secretions can obstruct the dramatically since 1940 when survival was reported
lumen of narrowed airways, which leads to reabsorp to be approximately 2 years of age. In1980, patients
tion atelectasis distal to the site of obstruction, im survival was estimated to be 20 years of age and in
paired gas exchange, and reduced P aoz. Thus mu creasing (Hunt and Geddes, 1985). Thus although
cociliary transport is a priority. Mucous clearance can CF is congenital and manifests in childhood, this
be further impclled by the addition of serous fluid to condition has now become an adult disorder. Adult
pulmonary mucus, resulting from airway irritation patients with CF often have an upper lobe infiltrate,
and inflammation. Cilia are less effective at clearing with evidence of atelectasis and bronchiectasis, and
mucoserous fluid compared with mucus alone. In ad chronic staphlococcal infections. The beat fre
dition, sheets of ciliated epithelium are shed into the quency of the cilia is often slowed to approximately
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484 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Thel'apy: Acute Cardiopulmonary Conditions
3 mm/min, compared w i t h 20 m m/min in age The clinical deficits related to oxygen transport in
matched healthy control subjects (Wood, Wanner, clude impaired mucociliary transport, increased mu
Hirsch, and Farrell, 1975). Patients can be catego cous production, increased difficulty clearing mucus,
rized into three general groups-those with no sig impaired ventilation and perfusion matching, right
nificant pulmonary signs, those with pulmonary to-left shunt, a diffusion defect, respiratory muscle
signs and occasional cough and sputum, and those weakness or fatigue, and reduced cardiopulmonary
with pulmonary signs and constant cough and spu conditioning (Chatham, Berrow, Beeson, Griffiths,
tum. Those patients in the last group tend to have Brough, and Musa, 1994). The incrcased production
significantly impaired pulmonary function test re of mucus and the difficulty removing mucus in
sults, reduced diffusing capacity, and increased he creases the risk of bacterial colonization and chronic
moptysis, particularly in the presence of an abnor respiratory infections. These manifestations of CF are
m a l che s t x - r a y a n d h y p e r i n f la ti o n . A i r w a y worsened with recumbency. Significant postural hy
hyperreactivity appears t o b e variable. poxemia has been reported in CF patients when mov
The A-a gradient for nitrogen reflects lung regions ing from sitting to a supine position (Stokes, Wohl,
with low ventilation and perfusion ratios. Peripheral Khaw, and Strieder, 1985). Thus the object of treat
airways are often abnormal either anatomically or ment is to optimize oxygen transport and pulmonary
functionally because of mucous plugging. The lungs gas exchange. Given the pathophysiological deficits
of patients with CF may be excessively stiff at maxi in an acute exacerbation of CF, the specific goals are
mal lung capacity, with a loss of elastic recoil at low to enhance mucociliary transport, promote airway
lung volumes (Mansell, Dubrawsky, Levison, Bryan, clearance, optimize alveolar ventilation and therefore
and Crozier, 1974). Regional ventilation is nonuni gas exchange, maximize the efficiency of oxygen
form contributing to ventilation and perfusion mis transport overall, and prevent and minimize infection.
match and hypoxemia (Cotton, Graham, Mink, and Although the degree to which patients with chronic
Habbick, 1985; Ross et aI., 1992a). lung conditions, and in palticular CF, can respond to
The chronic pulmonary limitation in CF is related aerobic training may be limited, it is essential that
to increased secretion of abnormally viscous mucus, their capacity to transport oxygen overall is optimized
impaired mucociliary transport resulting in airway ob to compensate for deficits in specific steps of the oxy
struction, bronchiectasis, hyperint1ation, infection, and gen transport pathway (Cystic Fibrosis and Physical
impaired regional ventilatory function, leading to im Activity, International Journal of Sports Medicine,
paired ventilation and perfusion matching and gas ex 1988; Dean and Ross, 1989). Deconditioning severely
change. Radiologically, changes are most pronounced impairs oxygen transport. Improved aerobic capacity
in the upper lobes, especially the right upper lobe. and cardiopulmonary conditioning is central in the
management of CF. Prescriptive aerobic exercise en
Principles of physical therapy management
hances the efficiency of oxygen transport overall by
Prophylactic cardiopulmonary physical therapy, in reducing airway resistance by mobilizing secretions,
cluding facilitation of mucociliary transport and max improving the homogeneity of ventilation in the lungs
imizing alveolar ventilation, in conjunction with the and therefore ventilation and perfusion matching, op
judicious use of antibiotics provides effective mea timizing oxygen extraction at the tissue level, and in
sures for controlling or s l o w i n g the effects of creasing respiratory muscle endurance (Keens,
bronchial and bronchiolar obstruction. Involvement Krastins, Wannamaker, Levison, Crozier, and Bryan,
of the patient and caregivers in chronic care in the 1977; Zach et aI., 1992). If optimal conditioning is
long term is particularly important. Understanding of maintained, oxygen transport is not as compromised
the pathology and course of CF is essential to modify during acute exacerbations given the improved effi
treatment prescription during exacerbations and re ciency of oxygen transport overall. These effects will
missions of the disease. be lost, however, as the patient deconditions with re
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27 Acute Medical Conditions 465
stricted mobility and recumbency the acute sure, because of the concomitant increase in intratho
episode. Thus it is important that is mlnl racic pressure and strain on the heart and lungs. Pa
maJly restricted during an exacerbation (based on the tients with CF have severe paroxysms of
clinical assessment and morbidity) and that exercise This increases intrathoracic pressure,
conditioning is a of between which in turn venous return and cardiac out
exacerbations. An important additional effect of put. Although coughing is an essential mechanism for
which has importance for CF clearance in these patients, the untoward
1 Shepard, cardiac effects need to be minimized.
and 1991). This may minimize Over the past other interventions aimed at
the risk of infection and perhaps minimize the secretion clearance in the treatment of CF have in
of an infection once acquired. cluded the use of the positive ex-
In severe exacerbations the patient is pressure mask, and the flutter valve
stressed has a increased 1993; Webber and Pryor, 1
oxygen in part because of the increased is based on the that the equal pres
work of breathing and for the and is prone to is shifted along the airways altering the
arterial desaturation. Thus minimizing undue oxygen volume at which the patient breathes. The pa
demand and the selection of treatment tient initially breathes and at low
interventions and their parameters in conjunction volumes, then at mid and high lung volumes,
with monitoring. These patients become at low lung volumes is believed to loosen
j.Jv,,,.-..tu'-" and distressed readily, Treatment interven secretions from the walls of the This is fol
tions are selected based on the assessment and the pa lowed at mid volumes, which be
tient's to tolerate the treatment and derive lieved to help localize and collect the secretions. Fi
benefit. Gradual, paced low-intensity mobi breathing at lung volumes is believed to
lization and body enhance mu centralize and facilitate the removal of the secretions
cociliary transport and clearance and maxi with Thus may enhance
mize t he efficiency of t h e s t e p s i n t h e o x y gen manipulat
transport pathway. Postural can offer addi ing volumes and flow rates and controlling
tional benefit in these patients if further clearance i s coughing to avoid unproductive and wastc
The addition o f manual may be ful of energy. The is coached by
indicated, however, monitoring must be car the therapist breathe and deliber
ried out given their potential deleterious effects on at the volumes set the who gauges
gas (Kirilloff, and Maz the patient's ventilatory effort and work with the
Murray, 1979; hands around the chest. The patient is not
1982). "'''''An"
'
,,,,..; to breathe below
... .. volume
Forced and expiratory techniques can and is encouraged to suppress coughing until the ex
contribute to airway whereas and (i.e., the phase which the patient
other forms of modified is breathing at high volumes),
tis minimize may be a useful adjunct for fa
tive in removing secretions that have accumulated cilitating airway clearance in with CF. It is a
centrally without compromising ventilation and gas procedure that may use independently and can
1974; Nunn, Sa be relatively unobtrusively. It
and Laws, 1965). Forceful the patient's efforts and minimizes the poten
closes, contributes to tial for airway closure in these
airway closure and thus should be avoided, The PEP mask and flutter valve are believed to re
lady in with elevated pulmonary artery pres duce airway closure and thereby alveolar
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486 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
ventilation and enhance mucociliary clearance in pa als exposed to plastics being heated at high tempera
tients with CF. tures are also exposed to gases that are toxic to the
respiratory system. Chronic pathological changes and
impaired gas exchange can result.
Acute Exacerbation of Interstitial Pulmonary Fibrosis
Medical management is directed at reducing in
Pathophysiology and medical management
flammation, reducing pulmonary hypertension, and
Interstitial lung disease has been associated with var increasing arterial oxygenation. Pharmacological
ious occupations and the inhalation of inorganic and management may include corticosteroids for inflam
organic dusts. Conditions associated with the inhala mation, immunosuppressive agents, and oxygen
tion of inorganic dusts include silicosis, asbestosis, therapy. Removing the patient from the work envi
talc coal dusts, and beryllium. These conditions are ronment contributing to interstitial pulmonary fibro
most often seen in miners, welders, and construction sis is essential in managing the disease and its long
workers. Workers exposed to organic material, such term consequences.
as fungal spores and plant fibers, may develop a seri
ous pulmonary reaction known as extrinsic allergic
PrinCiples of physical therapy management
alveolitis. Generally, interstitial lung disease is char The primary clinical manifestations of an acute exac
acterized by inflammation of the lung parenchyma, erbation of interstitial pulmonary fibrosis reflect an
which may resolve completely or progress to fibro acute on chronic problem usually resulting from an
sis. Interstitial pulmonary fibrosis results from the inflammatory episode, pulmonary infection, or both.
deposition of connective tissue after repeated bouts The mechanisms responsible include reduced alveo
of infection. lar ventilation, an inflammatory process and its mani
The pathophysiological deficits are commensu festations, potential airway obstruction, and increased
rate with morphological changes of interstitial infil work of breathing and of the heart in severe cases.
tration and fibrosis, intraalveolar exudate and alveo These patients are prone to desaturation during exer
lar replacement (Chung and Dean, 1989) (see Figure cise and thus need to be monitored closely.
4-12, p. 88). Lung compliance and lung volumes are In mild cases, mobilization increases the homo
reduced, expiratory flow at mid lung volume is in geneity of ventilation, and ventilation and perfusion
creased (stiff, inelastic lungs), diffusing capacity is matching (Jernudd-Wilhelmsson et aI., 1986). Be
reduced, and hypoxemia can be present in the ab tween treatments and in the management of the se
sence of hypercapnia (Chung and Dean; 1989; Jer verely affected patient, body positioning is used to re
nudd-Wilhelmsson, Hornblad, and Hedenstierna, duce the work of breathing and arousal, maximize
1986). The chest x-ray of a patient with interstitial alveolar ventilation, maximize ventilation and perfu
pulmonary fibr osis secondary to sarcoidosis is sion matching, and optimize coughing.
shown in Figure 4-12, p. 88. Other changes include Patients with moderate-to-severe interstitial lung
increased resting heart rate, pulmonary hyperten disease may desaturate during sleep (Perez-Padilla,
sion, impaired gas exchange, and shortness of breath West, and Lertzman, 1985) and readily desaturate on
during exercise and, in some cases, at rest. Symp physical exertion (Arita, Nishida, and Hiramoto,
toms can be reversed by removing the worker from 1981), thus warranting close monitoring during and
the exposure by a change of employment, by modi between treatments. Increased pulmonary vascular re
fying the materials handling process, or by using sistance secondary to hypoxic vasoconstriction con
protective clothing and masks. Repeated exposure to tributes to increased work of the right heart and po
these organic dusts may result in irreversible inter tential cardiac insufficiency.
stitial fibrosis. General debility and deconditioning warrant a
Reaction to fumes and gases can also lead to modified exercise program that can optimize the
chronic restrictive patterns of lung disease. Individu function of all of the steps in the oxygen transport
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27 Acute Medical Conditions 487
pathway (Arita et aI., 1981; Chung and Dean, 1989). in milder cases. If fibrosis has occurred, lung compli
ance will be correspondingly reduced. Airflow resis
tance may be increased from narrowing or distortion
Tuberculosis
of the bronchioles because of fibrosis. Pleural in
Pathophysiology and medical management
volvement may result in effusions, empyema, pleural
Although the incidence of tuberculosis, a life-long fibrosis, and spontaneous pneumothorax. Unlike
disease, has declined significantly over the past sev parenchymal damage, small amounts of pleural re
eral decades, this disease has been experiencing a striction can produce significant changes in pul
resurgence in the industrialized world in recent monary function. Clinically, patients with significant
decades. This may reflect declining sanitation and pleural involvement have significant restrictive dis
health standards in some segments of the population ease and correspondingly low lung volumes. The
and immigration patterns. work and energy cost of breathing are markedly in
Most infections result from inhalation of airborne creased. Shortness of breath is a common complaint.
tubercle bacilli, which triggers an inflammatory re Comparable with an interstitial pulmonary fibrosis
sponse (luce, 1986). This response includes flooding patient, the patient adopts a rapid shallow breathing
of the affected area with fluid leukocytes, and later pattern to reduce the high cost of elastic work of
macrophages. The area becomes consolidated and breathing. Thus the dead space tends to be hyperven
pathologically the condition is considered a tubercu tilated and alveolar hypoventilation results.
lous pneumonia. The infiltrating macrophages be In addition to alveolar hypoventilation, lung tissue
come localized and fused, resulting in the characteris and pulmonary vascular damage impairs ventilation
tic tubercle. Within 2 to 4 weeks, the central part of and perfUSion matching and diffusing capacity. In se
the lesion necroses. Tuberculosis is associated pri vere cases, hypoxemia and hypercapnia are present.
marily with pulmonary infection that is comparable Chronic adaptation includes polycythemia and hyper
with other infectious pneumonias. Tuberculosis, how volemia. Right heart failure may ensue.
ever, is distinct in that it may affect other parts of the The lungs become shrunken and geometrically
body. Symptoms include fatigue, fever, reduced ap distorted because of fibrotic changes in the lungs.
petite, weight loss, night sweats, hemoptysis, and a These changes can lead to kinking and obstruction of
cough with small amounts of nonpurulent sputum the pulmonary blood vessels and maldistribution of
with pulmonary involvement. The course of the dis pulmonary blood flow, which further compromises
ease is variable. Some lesions heal promptly, whereas ventilation and perfusion matching.
other patients experience progression and ensui ng Tuberculosis may be associated with an obstruc
death. Other systems that can be involved include tive component. An increase in airflow resistance
brain and meninges, kidney, reproductive system, and comparable with emphysema can be present. This ob
bone. In some individuals the disease appears to struction results from chronic infection, mucosal
remit, whereas in others tuberculosis progresses to af edema, retained secretions, and bronchospasm.
fect other organ systems or previously dormant foci Antibiotics can be effective in managing the dis
can be reactivated. ease such that hospitalization is avoided. If detected
The effects of tuberculosis on pulmonary function early, the prognosis is favorable, provided the patient
are variable, depending on the extent and type of le adheres to the medication schedule and the bacilli do
sions. lesions may involve the lung parenchyma, the not become resistant to the medications. Surgery may
bronchi, the pleurae, and chest wall. Parenchymal i n be indicated to resect lung segments that are chroni
volvement can reduce lung volumes, leading to hy cally involved. The extent and seveJ;ty of the disease
poventilation of pelfused lung units. Significant dis determines the course of recovery.
ease leads to impaired artcrial blood gases, whereas The maintenance of good general health is particu
areas of unaffected lung may adequately compensate larly important in the management, control, and pre
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488 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
vention of tuberculosis (e.g., sanitation, balanced whether the patient is being treated for osteoarthritis,
diet, sleep, regular exercise, and stress control). stroke, or cardiopulmonary dysfunction, treatment is
modified accordingly. An exercise prescription in
Principles of physical therapy management cludes generalized aerobic exercise at an intensity
Although the acute presentation of tuberculosis is com that is optimally therapeutic and not associated with
parable with acute pneumonia (refer to pneumonia sec any excessive or untoward hemodynamic responses
tion), there are some important differences with respect (Blair, Painter, Pate, Smith, and Taylor, 1988).
to physical therapy management. First, tuberculosis is Labile hypertensive patients are the most difficult
particularly infectious, thus special precautions should patients to prescribe an exercise program for because
be taken by the physical therapist to prevent its spread of the irregularity of their blood pressure responses.
during its infectious stage. Second, patients are prone to The intensity is modified at each session to accom
excessive fatigue; treatments should be selected to pro modate these variations. Because beta-blockers and
mote improved oxygen transport without exceeding the other medications blunt heart rate responses to exer
patient's capacity to deliver oxygen and without con cise, the exercise prescription parameters are defined
tributing to excessive fatigue. Stimulation of the oxy on the basis of some other objective hemodynamic
gen transport system with exercise is necessary to avoid response or on subjective responses (e.g., the Borg
the deleterious effects of deconditioning and further scale of perceived exertion).
compromise of oxygen transport. The patient therefore The benefits of a modified aerobic exercise pre
warrants being monitored closely. scription include elimination of medication, reduction
of medication, and improved pbarmacological control
on the same dose of medication. In addition, the pa
Hypertension
tient derives all the other multisystem health benefits
Pathophysiology and medical management
of exercise. A program of aerobic exercise should be
Essential hypertension is the most common type of carried out in conjunction with other life-style changes
hypeltension (90% of all reported cases) (i.e., of un associated with blood pressure control (e.g., nutrition,
known etiology). Generally, hypertension is classified weight control, stress reduction, and smoking cessation
as mild, moderate, or severe. Hypertension is man program). Medications should be monitored by the
aged pharmacologically with vasodilators (i.e., after physician during the training program. In addition to
load reducers), diuretics (i.e., volume reducers), and exercise having a direct effect on controlling hyperten
beta-blocking agents (i.e., inotrophic agents). Hyper sion, the effect of exercise on overall metabolism may
tension is a significant health-care concern in that this alter the absorption and degradation of the medica
condition is frequently associated with heart disease tions, which in turn can reduce the prescriptive re
and stroke. Thus its consequences can be dire. quirements of that medication. Those types of exercise
that are associated with a disproportionate hemody
Principles of physical therapy management
namic challenge (e.g., static movements and stabilizing
Physical therapists treat patients with hypertension as postures) are not usually indicated. Rather, aerobic ex
a primary or secondary condition. A prescription of ercise that is rhythmic, involves the large muscles of
regular aerobic exercise may control hypertension the legs and possibly the arms, and is performed fre
(Froelicher, 1987; Goldberger, 1990). The prescrip quently is indicated (Blail: et aI., 1988).
tion is based on a consideration of the patient's coex
istent problems and general health status. If obesity is
Angina
a concurrent problem, an exercise program is pre
Pathophysiology and medical management
scribed to address both concerns.
More frequently, physical therapists treat patients Angina refers to pain resulting from ischemia of the
whose hypertension is a secondary condition. Thus, myocardium and often precedes myocardial infarction.
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27 Acute Medical Conditions 489
Coronary cutery disease is the primary cause of myocar propriately? Is the prescription current? Are
dial infcu'ction and is among the leading causes of death there other medications that may influence the
in the Western world. Life-style factors including rugh patient's cardiopulmonary status and response to
fat diet, stress, and low activity levels contribute to ath treatment? What are they? Does the patient have
erosclerosis and fat deposition within the coronary the antianginaJ medication present at all times?
blood vessels. When these deposits narrow or totally 5. What physiological parameters should be moni
occlude the vessel lumen, blood flow is restricted or to tored before, during, and after treatment?
tally obstl11cted. As the hecut continues to demand oxy 6. What is the patient's knowledge about his or
gen and nutrients to work, blood supply needs to be in her condition? Can the patient clearly identify
creased. If one or more of the myocardial blood vessels what triggers the angina and what makes it
is stenosed, insufficient blood reaches the working my worse and better? What life-style changes have
ocardial fibers, and ischerrua and pain result. Although been made? What should be reinforced and
the classic description of anginal pain is retrosternal what education is needed?
vice-like, gripping pain radiating to the left side and A key consideration in the management of any pa
down the arm and up into the neck, anginal pain may tient with cardiovascular dysfunction is minimizing
occur bilaterally anywhere above the umbilicus. Fur myocardial strain (Sokolow et aI., 1990). Thus mobi
thermore, patients vary considerably with respect to the lization and exercise prescription needs to incorpo
degree to which the severity of the pain correlates with rate an appropriate warm-up, steady-rate, cool-down,
the degree of myocardial ischemia and infarction. Thus and recovery phases, and the type of exercise should
even apparently minimal chest pain may be associated be rhythmic and involve the legs (i.e., areas of large
with significant ischemia and should not be rrunirruzed muscle mass) and possibly the arms as well. Initially,
with respect to its clinical significance. low-intensity activity that restricts the heart rate to no
more than 20 beats above resting heart rate may be
Principles of physical therapy management
indicated to minimize the work of the heart without
The management of patients with healt disease who immobilizing the patient completely. Ejection frac
are hemodynamically unstable and require intensive tion is not necessarily a good indicator of exercise
monitoring to assess and to monitor physical therapy tolerance because these vruiables are not well corre
treatment is described in Chapter 32. This chapter ad lated (Dean, 1993). Upper-extremity work alone is
dresses the management of the cardiac medical patient more hemodynamically demanding than lower ex
who is stable and uncomplicated. Physical therapists tremity work and thus is prescribed cautiously if at
must be knowledgeable and proficient in the manage all, at least in the early stage. Exercise or physical ac
ment of the cardiac patient because these patients are tivity, involving sustained static postures and isomet
referred with cardiac disease as a primary or secondary ric muscle contraction, are contraindicated. Breathing
problem. Because physical therapy invariably involves should be coordinated with activity such that breath
physically stressing a patient either with therapeutic holding and straining are avoided.
exercise or with the application of a therapeutic modal A patient with a history of angina, regardless of
ity, the physical therapist must address the following whether that individual is taking antianginal medica
questions when managing a patient with heart disease: tions, must be hemodynamically monitored (i.e.,
I. Does the patient's cardiac status preclude treat heart rate, blood pressure, rate pressure product, and
ment? Why? subjective responses).
2. Is additional information on the patient needed Patients prone to angina may exhibit symptoms in
before physical therapy assessment and treat certain body positions (L ange, Katz, McBrid e ,
ment? What information? Moore, a n d Hillis, 1988; Langou, Wolfson, Olson,
3. How should treatment be modified? Why? and Cohen, 1977; Prakash, Parmley, Dikshit, For
4. Is the patient using antianginal medication ap rester, and Swan, 1973). Usually, this reflects an in
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490 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
creased workload and increased work of the heart. agement of the myocardial infarction patient (Harri
Recumbent positions increase the mechanical work son, 1944). Because these interventions can place sig
of the heart by increasing central blood volume nificant demands on cardiopulmonary function and
(Kaneko, Milic-Emili, Dolovich, Dawson, and Bates, oxygen transport, they must be prescribed specifi
1966). These patients are not encouraged to lie flat, cally by physical therapists with considerable knowl
instead the head of bed is elevated 10 to 15 degrees. edge and expertise in the area.
Sidelying positions, particularly left sidelying, in
Principles of physical therapy management
crease the work of the heart by compressing the heart
and impeding ventricular filling and ejection. Patients Physical therapy stresses patients hemodynamically
with impaired oxygen transport and without prior car (Dean, Murphy, Parrent, and Rousseau, 1995). Thus
diac disease may exhibit myocardial stress and is the adequacy of their cardiopulmonary system to ef
chemia in these body positions. Thus patients with fect oxygen transport during and between treatments
impaired or threatened oxygenation must be moni is essential to establish. The optimal treatment pre
tored closely, particularly during turning and activi scription is based on the patient's overall signs and
ties in which oxygen demand is increased and oxygen symptoms of coronary insufficiency and hemody
delivery needs to increase cOITespondingly. namic instability. The physical therapist must be
knowledgeable in detecting inadequate myocardial
tissue perfusion and in reducing and preventing my
Uncompliicated Myocardial Infarction
ocardial tissue damage. In addition, acute or chronic
Pathophysiology and medical management
impaired heart pump function leads to reduced car
Myocardial infarction commonly referred to as a diac output and systemic tissue perfusion. Clinical
heart attack refers to insufficient myocardial pelfu manifestations include reduced mentation, reduced
sion resulting in a macroscopic area of damage and renal function, fatigue, malaise, and moist, cool, and
necrosis of the heart. Infarction results most fre cyanotic skin.
quently from narrowing and occlusion of the coro Regardless of whether the patient i s being
nary blood vessels secondary to atherosclerosis. treated in hospital, either on the ward or in the de
Other causes include occlusion secondary to a throm partment, or in the private physical therapy clinic,
bus or embolus, reduced blood pressure, or coronary the patient must be hemodynamically monitored.
vasospasm. Angina, or ischemic chest pai n, often Minimall y, heart rate and blood pressure must be
precedes or accompanies a myocardial infarction. In taken before, during, and after treatment, along
farctions vary in severity from being silent (i.e., hav with a subjective rating of anginal chest pain. ECG
ing no characteristic signs and symptoms) and thus monitoring is usually continuous in the early stages
going undetected to being fatal. Most infarctions of the infarction. The object of treatment is to have
when detected require some hospitalization and mon the patient remain below his or her anginal thresh
itoring to ensure that the infarction is not evolving old so that anginal pain is avoided. Breathlessness
further and that the patient is medically stable and in or rating of perceived exertion may also be used.
no danger. Chapter 32 describes the management of The rate pressure product (RPP) (i.e., the product
patients with myocardial infarctions who are admit of heart rate and systolic blood pressure) is highly
ted to a coronary care unit. This section focuses on correlated with myocardial oxygen uptake and
the patient with mild heart disease, the medical car work. Previous stress tests will establish the RPP
diac patient who is discharged from hospital, the pa at which angina occurs and the intensity of the ex
tient who has a history of ischemic heart disease, and ercise dose should be set at 65% to 80% of this
the patient who is hospitalized for a condition other threshold. Patients on beta-blockers have a blunted
than heart disease but develops and is being managed hemodynamic response to exercise, particularly
for myocardial ischemia. Judicious movement and heart rate responses. Use of ratings of perceived
body positioning are essential elements in the man exertion to define the upper and lower limits of an
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27 Acute Medical Conditions 491
acceptable mobilization stimulus may be indicated they can undertake. Thus performing physical activ
in these patients. ity and exercise while monitored and under the su
In some cases, patients have labile angina (i.e., the pervision of a physical therapist is often reassuring
onset of angina does not occur reliably at a given and gives the patient confidence for performing ac
RPP). This patient and the patient who reports angina tivity when unsupervised.
at rest are at higher risk and appropriate precautions The quality and quantity of the patient's sleep and
must be taken. First, the patient must be assessed to a profile of sleep-wake periods should be reviewed to
establish that treatment is not precluded (see pertinent ensure he or she is deriving maximal benefit. REM
questions to be answered before treating a patient sleep with bursts of sympathetic activity during the
with angina). Second, monitoring is essential and early hours of the morning may constitute a period of
may include ECG monitoring. Third, treatments are increased risk for the cardiac patient.
prescribed below symptom threshold, which is usu Appropriate safety precautions must be taken in
ally consistent with a low exercise intensity in these all settings where physical therapists practice, given
patients. Comparable with any patient experiencing that most physical therapy interventions physically
low functional work capacity, exercise prescribed on stress patients and that coronary symptoms can occur
an interval schedule enables the patient to achieve a regardless of whether the patient has a known under
greater volume of work. lying heart disease. In addition, because the popula
Similar to the patient with angina, body positions tion is aging, physical therapists are treating a grow
are selected for the patient with a myocardial infarc ing number of older persons who are known to have a
tion that will minimize the work of breathing and of higher prevalence of cardiovascular disease.
the heart (Sonnenblick, Ross, and Bruanwald, 1968). Good life-style habits are central to maximizing
Significant central fluid shifts are minimized by en recovery and improving the long-term prognosis
couraging the upright position as much as possible to (e.g., good nutrition and hydration, good sleep habits,
reduce the work of the heart (Levine and Lown, stress management, and regular physical exercise that
1952) and by maintaining the head of bed up to 10 to is prescribed by the physical therapist) (Underhill et
15 degrees when the patient is recumbent. Patients aI., 1989).
with elevated intracardiac pressures are less suscepti
ble to orthostatism (Chapter 18).
SUMMARY
Comparable with the management of the patient
who has a history of angina, body positions, static The primary acute cardiopulmonary medical condi
postures, activities, and respiratory maneuvers associ tions that are treated by physical therapists include
ated with increased hemodynamic strain (e.g., breath primary lung dysfunction (i.e., atelectasis, pneumo
holding) are avoided. nia, bronchitis, bronchiolitis, alveolitis, alveolar pro
Relaxation is central in the management of the teinosis, and acute exacerbations of chronic airflow
cardiac patient who is prone to being anxious and limitation, asthma, cystic fibrosis, interstitial pul
apprehensive. Relaxation interventions include auto monary fibrosis, and tuberculosis) and primary car
genic relaxation, progressive relaxation, Benson's diac disease including hypenension, uncomplicated
relaxation response procedures. biofeedback, and angina, and myocardial infarction. This chapter fo
meditation (Underhill et aI., 1989). Also, the patient cuses on the pathophysiology underlying these disor
needs to identify and minimize stress triggers and ef ders and the mechanisms by which they threaten or
fective individual-specific nonpharmacological re impair heart-lung interaction and oxygen transport.
laxants. Relaxation training with or without pharma Thus the basis for the principles of cardiopulmonary
cological support can be integrated into treatment physical therapy are described rather than specific
(Underhill et aI., 1989; Webber and Pryor, 1994). treatment prescriptions. Treatment prescription is
Patients with heart disease are often apprehensive based on the effects of restricted mobility, recum
and anxious about the intensity of physical activity bency, and extrinsic and intrinsic factors in addition
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492 PART IV Guidelines fOl" the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
to the underlying is directed Bennett, W.o., Foster, W.M., & Chapman, W.E (1990). Cough
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Copyrighted Material
Acute Surgical Conditions
Elizabeth Dean
Maureen Fogel Perlstein
Mary Mathews
INTRODUCTION
The four categories of factors contributing to or
The purpose of this chapter is to review the manage threatening oxygen transport are described in Chapter
ment of cardiopulmonary dysfunction secondary to 16. Specifically, these factors include the underlying
acute surgical conditions. The cardiopulmonary ef pathology, restricted mobility, and recumbency, ex
fects of surgery are described. The two types of trinsic factors related to the patient's care and intrin
surgery that have the greatest impact on cardiopul sic factors related to the patient. This chapter exam
monary function, namely, thoracic and cardiovascular ines in detail the extrinsic factors related to surgery
surgery, are then presented. These surgeries are par and anesthesia and the impact of underlying disease,
ticularly invasive and lengthy, require heavy and pro restricted mobility, recumbency, and intrinsic factors
longed anesthesia and sedation, and are associated on the effects of surgery and anesthesia.
with increased risk, thus warranting intensive periop Treatment principles are presented. These are not
erative physical therapy. intended to be a treatment prescription for a particular
495
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496 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
Incisions
PERIOPERATIVE COURSE
Use of the cardiopulmonary bypass machine (CBM)
Surgery and its Cardiopulmonary Consequences
Use of the extracorporeal membrane exchanger
Many factors contribute to perioperative cardiopul (ECMO)
monary dysfunction (see the box at right). Anesthesia
Dressings and binders
and tissue dissection contribute to major changes in
Splints and fixation devices
lung volume, mechanics, and gas exchange. The ex
Lines and leads
tent and duration of these changes increase with the
magnitude of the operative procedure and degree of Monitoring devices
anesthesia required. Anesthesia results in depression Chest tubes placement and number
of breathing. Thoracic respiratory excursion is signifi Catheters
cantly reduced. The tone and pattern of contraction of
Perioperative pain
the respiratory muscles, particularly the diaphragm
Perioperative pain control management
and the intercostal muscles, change, which contributes
Peri operative fluid balance management
to many of the secondary cardiopulmonary effects ob
served after surgery (Muller, Volgyesi, B e cker, Perioperative blood and plasma transfusions
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28 Acute Surgical Conditions 497
because of irritation of the airways. Because of the fect is indicated. Patient controlled analgesia (PCA)
decrease in FRC, compliance is decreased and the is an effective means of having the patient regulate
work of breathing is increased. Hypoxemia secondary the amount of analgesia he or she is receiving. Intra
to transpulmonary shunting is usually maximal venous administration prolongs the peak-effect time
within 72 hours after surgery and often is not com of analgesics and therefore helps the patient tolerate
pletely resolved for several days. Persistent reduction longer, more intense treatments. Transcutaneous elec
in FRC after surgery delays .the restoration of the nor trical nerve stimulation (TENS) can be a useful ad
mal alveolar-arterial oxygen gradient (Alexander, junct in the management of postoperative pain in
Spence, Parikh, and Stuart, 1973). some patients. Pain control with TENS may enable
A complication of thoracic and upper abdominal the patient to participate more fully in mobilization,
surgery, (e.g., cholecystectomy) is irritation or com deep breathing, coughing, and bed mobility. Research
pression trauma of the phrenic nerve. This complica is needed, however, to evaluate this technique in the
tion may be more common than expected. Inhibition management of acute pain and define the prescription
of the phrenic nerve impairs the contraction of the af parameters needed to produce an optimal therapeutic
fected hemidiaphragm, causing it to ascend into the effect. A nonpharmacological, noninvasive means of
thorax and contribute to atelectasis on that side. This managing acute pain would be of considerable bene
inhibition may last for several days (Dureuil, Viires, fit to patients and would enable them to participate
and Cantineau, 1986; Ford and Guenter, 1984). more fully in physical therapy treatments in the ab
The FIo2 depends on the mode of 100% oxygen sence of untoward side effects often associated with
administration. Low-flow nasal oxygen reduces hy drug administration.
poxemia in the absence of hypercapnia and marked Although sedatives or tranquilizers are prescribed
transpulmonary shunting in the postoperative patient. to make the patient more comfortable and to reduce
Low oxygen flows and low FI02S tend to be delivered suffering, sedatives, in particular, reduce the patient's
via nasal cannulae, whereas higher flows can deliver arousal and often the ability to cooperate actively
higher FIo2s via oxygen masks and masks with reser with treatment. Thus these medications must be pre
voir bags. FIo2 and the body position of the patient at scribed judiciously to ensure the patient is able to co
the time the blood sample was taken must always be operate with physical therapy and other components
considered when interpreting arterial blood gases. The of care. Oversedation must be avoided if the patient
FIo2 is selected to provide adequate oxygenation with is to derive maximal benefit from cardiopulmonary
the lowest oxygen concentration possible. physical therapy treatments.
After surgery the normal pattern of breathing is Special attention in the postoperative period is
disrupted. Shallow, monotonous tidal ventilation given to the prevention or management of cardiopul
without normal occasional, spontaneous deep breaths monary complications associated with reduced arousal,
causes alveolar collapse within an hour (Nunn, 1989). surgical pain, and restriction of lung capacity and sec
Unless resolved, atelectasis becomes increasingly re ondary to dressings, binders, and diminished ability to
sistant to reinflation within a few hours. This compli cooperate, move spontaneously, and hyperventilate the
cation is exacerbated in patients receiving narcotics. lungs periodically. Patients are prone to aspiration in
Tachypnea and tachycardia are commonly ob the immediate postoperative period, particularly while
served with gross atelectasis secondary to hypoventi the sedation and anesthetic agents are wearing off.
lalion. Breath sounds are decreased at the bases, and This risk is further increased if an airway is required or
the coarse wheezes associated with mucus obstruct if an airway and mechanical ventilation is instituted.
ing airflow are heard on auscultation. Large areas of Postextubation atelectasis must be anticipated and
atelectasis are present. Left lower lobe atelectasis is avoided. To minimize this risk, patients are requested
common after cardiac surgery. not to cat or drink fluids the day before surgery.
If narcotics impair the patient's ability to partici Endotracheal intubation and mechanical ventila
pate in treatment, analgesia with a less systemic ef tion are indicated if blood gases fail to improve with
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498 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
conservative management. See Chapter 32 for treat tively, he or she will be better oriented and capable
ment priorities for a patient during ventilation and the of cooperating when waking from anesthetic.
course of weaning from the mechanical ventilator. The patient's position is changed frequently in the
The importance of a thorough preoperative as initial postoperative period. The patient is usually en
sessment and teaching by the physical therapist can couraged to change his or her body position fre
not be overstated. The components of preoperative quently, transfer, sit in a chair, and ambulate as soon
teaching are summarized in the box below. In cases as possible after surgery. The importance of frequent
of elective surgery, preoperative teaching includes a postural changes and early ambulation in the initial
general description of the surgery to be performed, postoperati ve period are stressed (Dull and Dull,
the effect of anesthesia and surgery on cardiopul 1983). Early ambulation is a priority in the manage
monary function, and the systemic effects of re ment of all surgical patients unless contraindicated.
stricted mobility and recumbency. The lines, leads, After surgery, the patient is detained in the recovery
and catheters usually associated with the surgery are room until the vital signs have stabilized, there is no
explained. The patient i s instructed in breathing apparent internal or external bleeding, and the patient
control maneuvers, supported coughing, chest wall is responding to his or her name. Patients recovering
mobility exercises, mobility exercises for the limbs from minor surgery are usually transferred to a ward
(e.g., hip and knee and foot and ankle exercises), once discharged from the recovery room. A patient is
turning in bed, sitting up, transferring, chair sitting, transferred to the ICU after surgery if complications
and walking erect postoperatively. In addition, the arise during surgery, if the patient cannot be readily
patient is taught methods of maximizing comfort stabilized and requires close monitoring, or if the pa
with body positioning and supporting the surgical tient has had more serious surgery such as cranial, car
incision. If the bed has controls the patient can ma diovascular thoracic, or emergency surgery, such as
nipulate, she or he is taught how to make bed adjust that resulting from mUltiple trauma (Chapter 34).
ments as required. The postoperative course is ex P a tients considered for elective surgery are
plained in general terms so the patient can anticipate screened regarding their risks for postoperative
this period. If the patient is well informed preopera complications. The physical therapist is often con-
Assess the patient and estimate degree of surgical risk (e.g .. age, smoking. previous cardiopulmonary dysfullction,
neuromuscular dysfunction. musculoskeletal deformity, obesity. substance abuse, pregnancy. nutritional status,
and hydration status)
Review specific surgical procedures relevant to physical therapy (e.g., anesthesia. type of surgery. body position dur
ing surgery, airway, mechanical ventilation, duration, incisions, infusions. drainage systems, chest tubes. and re
covery room)
Provide the rationale for, describe, demonstrate, and have the patient practice and provide feedback on the following
breathing control maneuvers: maximal inspiratory hold, supported coughing maneuvers, relaxation, bed mobility
and positioning, transfers, and mobilization
For patients at risk of postoperative cardiopulmonary dysfunction and complications. review the use of the incelltive
spirometer and conventional airway clearance interventions (e.g .• postural drainage and manual techniques if indicated)
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28 Acute Surgical Conditions 499
su lted by the surgeon to help make a poor-risk pa ing suboptimal, suprathreshold physiological states.
tient into a relatively better-risk patient. Patients Suprathreshold states are associated with an inappro
wit h upper-respiratory tract infections before priate balance between oxygen delivery and demand
surgery may have their surgeries postponed, de such that the patient becomes compromised (e.g., he
pending on the type and extent of surgery to be per modynamically unstable), cardiopulmonary distress
formed, levcl of anesthesia indicated, and other is precipitated, or botb).
medical conditions, including cardiopulmonary dis
ease, age, and smoking history. Patients with lower
Preparation for Surgery
respiratory tract infections preoperatively constitute
a greater operative risk, hence these patients often To minimize risk and reduce perioperative morbidity
have their surgeries postponed until the infection and mortality, patients need to be in the best medical
has resolved. Patients with chronic cardiopulmonary and physical condition before anesthesia and surgery.
diseases require a prolonged period of preoperative In the case of elective surgery, some patients are pre
physical therapy in preparation for surgery. Elective scribed modified aerobic training, smoking cessation,
surgery is not usually considered during an exacer and weight control programs before surgery.
bation of chronic lung disease. Even minor surgery Preoperative teaching is a central component of
may be potentially hazardous for the patient with physical therapy management of the surgical patient.
previous lung disease. The adverse effects of total Such teaching establishes rapport with the physical
anesthesia on these patients is magnified because of therapist who informs the patient about what to ex
their reduced pulmonary reserve capacity. Smoking pect before and after surgery. In addition to review
should be discontinued for as long as possible be ing the surgical procedures, the physical therapist re
fore surgery. The patient is placed on an exercise views, and has the patient perform, deep breathing
conditioning program, a regimen of bronchial hy and supported coughing maneuvers, relaxation, bed
giene, oxygen if necessary, and prophylactic antibi mobility, positioning, transfers, and mobilization.
otics. Even patients with extremely low functional Preoperative teaching reduces the patient's anxiety
work capacity can enhance the efficiency of the and encourages the patient to be as active as possible
steps in the oxygen transport pathway (Chapter 17) in her or his recovery. Preoperative teaching reduces
with a modified aerobic exercise conditioning pro postoperative complications and the length of the
gram. This preoperative preparation may take one to hospital stay.
several weeks, depending on the patient and the in There are no strict guidelines ahout which patients
dications for surgery. should receive peri operative physical therapy. Al
Rest during the postoperative period is prescribed though nonthoracic surgeries are generally associated
judiciously as treatment because rest is the time for with fewer cardiopulmonary complications (e.g.,
healing, repair, and restoration. Sleep deprivation im surgery of the extremities or lower abdomen), patients
pairs recovery and healing. Sleep at night is biologi with preexisting cardiopulmonary, hematological or
cally more restorative than daytime sleep. Thus day neuromuscular pathology, or musculoskeletal pathol
time and nighttime cues are given to restore the ogy of the chest wall are at greater risk even in these
patient's circadian rhythms. Although injudicious and relative low-risk types of surgeries. In addition, pa
excessive recumbency, bedrest, and prolonged peri tients are at additional risk if they are older or
ods in any given body position are deleterious, spe younger, smoke, or are overweight or pregnant. Thus
cial attention is given to maximizing the amount of each surgical patient needs to be assessed individually
quality rest and sleep periods and minimizing disrup to establish the degree of relative risk during surgery
tion of nighttime sleep. Rest needs to be prescribed and the need for perioperative physical therapy. In this
both within and between treatments. Appropriate rest way, perioperative complications can be anticipated
periods are interspersed witbin eacb treatment ses and avoided or reduced, which is preferable to manag
sion, according to the patient's needs to avoid reacb ing complications once they have developed.
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500 PART IV Guidelines for the Delivery of Cat'diopulmonary Physical Thet'apy: Acute Cardiopulmonary Conditions
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28 Acute Surgical Conditions 501
the good lung," a patient prefers to lie on the non nary artery bypass grafting, valve replacements, and
surgical side. However, prolonged periods in any aneurysm repairs. Bypass patients, in whom the
position, and particularly, lying on the unaffected saphenous vein is excised for graft material, have the
side, places these lung fields at risk. To minimize added complication of surgery and wound healing in
the risk of positional complications and hypoxemia, one leg. Mobility exercises on that leg are often re
the patient is encouraged to turn to both sides stricted until there is no risk of bleeding or interfer
(Leaver, Conway, and Holgate, 1994; Seaton, Lapp, ence with healing. Comparable with the thoracic sur
and Morgan, 1979; Sutton, Pavia, Bateman, and gical patient, a cardiovascular patient leaves the
Clarke, 1982). The specific positions and the dura operating room with various monitoring Jines and
tion of time spent within each, however, is based on leads, intravenous fluid infusions, possible blood or
a comprehensive assessment of the patient's condi plasma infusions, a Swan-Ganz catheter (Chapter
tion and the indications and contraindications for 15), a central venous pressure line, an arterial line, a
each body position. Foley catheter, and oxygen cannulae.
Patients may appear to splint themselves, thereby The preoperative preparation and teaching and
restricting chest wall motion, to avoid including pain the postoperative physical therapy management is
when moving and deep breathing. They also may re intensive. Because of the invasiveness of cardiovas
sist maximal inspiratory efforts when coughing. Al cular surgery, patients are usually treated postopera
though pain likely contributes to breathing at low tively in a specialized intensive care unit (Chapter
lung volumes and ineffective coughing, phrenic nerve 31). The preoperati ve and postoperative physical
inhibition in patients with thoracic and upper abdomi therapy management of patients in the intensive care
nal surgeries is likely a more important factor re unit is a specialized area and is described in Chapter
stricting lung expansion than is fully appreciated in 34. Providing the patient with information about
many patients (Ford and Guenter, 1984). what to expect during the perioperative course re
Postoperative complaints of pain are both muscu lieves fear and anxiety. In addition, relaxation pro
loskeletal and pleural in origin. The large number of cedures can be useful. Patients need to be reassured
muscles incised, particularly in the posterolateral tho that their incisions and suture lines will not be dis
racotomy incision, combined with the operative posi rupted with movement and physical therapy and that
tion, contributes to the patient's complaints of chest supported coughing and supporting themselves
wall pain, shoulder soreness, and restricted move when moving will maximize comfort. Until the pa
ment. Deep breathing and coughing maneuvers may tient has stabilized, the patient's mobility is re
be associated with considerable discomfort after stricted to low-intensity mobilization to promote its
surgery. Pain is accentuated by apprehension and benefits on gas exchange and reduce metabolic de
anxiety. Therefore treatments are coordinated with mands and body positioning to optimize alveolar
relaxation, noninvasive pain control modalities, and ventilation coordinated with deep breathing and
pain medication schedules to elicit the full coopera supported coughing maneuvers. Conventional air
tion of the patient. way clearance interve n tio ns (e.g., postural drainage
and manual techniques) may be prescribed in the
presence of excessive secretions, difficulty in mobi
Cardiovascular Surgery
lizing secretions, and in the event of productive hy
Cardiovascular surgery is specialized thoracic drostatic pneumonia.
surgery involving the heart and great vessels. Be Patients undergoing cardiovascular surgery are
cause the flow of blood through the cardiopulmonary transferred from the cardiovascular intensive care
system is interrupted, the patient is placed on a car unit to the ward as quickly as possible. From the
diopulmonary bypass machine or on a machine called ward, these patients should be referred to a physical
an extracorporeal membrane oxygenator. Cardiovas therapist and a cardiac rehabilitation program in the
cular surgery is most commonly performed for coro community for continuity of care and to maximize
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502 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
cause strain. Patients with median sternotomy inci Optimize lung compliance
sions are usually prohibited from using their anns to Optimize mucociliary transport
support themselves when sitting or driving and dur
Optimize mucous clearance
ing activities that may strain the incision site for sev
Optimize ventilation and perfusion matching and
eral weeks or more.
gas exchange
Preoperative management includes assessment and Optimize lung water balance and distribution
preoperative education; the primary components are Promote optimal lymphatic draining
shown in the box on p. 498. During this time the phys
Minimize third spacing and collection of fluid
ical therapist has an opportunity to develop rapport
Minimize the risk of aspiration
with the patient. The assessment establishes the risk of
Minimize undue work of breathing
cardiopulmonary complications and prolonged hospi
tal stay and the type and extent of perioperative physi Minimize undue work of the heart
cal therapy required. The assessment establishes what Maximize chest wall mobility and movement in
the postoperative priorities will be; however, these are three planes
modified based on the postoperative assessment. The Optimize body and posture alignment when sitting,
surgical procedures are described and the effects of standing. walking, and recumbent
surgery and anesthesia and sedation on gas exchange Optimize circulatory status and tissue perfusion
are reviewed so that the patient understands the im Optimize peripheral blood flow and velocity
portance of being actively involved in physical ther
Optimize muscle pump actioll
apy, both dUling and between treatments after surgery.
Minimize effects of central fluid shifts with recum
bency
tween and during treatments. Thus the patient is in Provide instruction to patient on "between-treat
structed in mobilization and body positioning coordi ment" treatment
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28 Acute Surgical Conditions 503
maneuvers between treatment sessions, and these in going thoracic or cardiovascular surgery, are usually
terventions should be performed hourly during wak extubated before leaving the operating room or re
ing hours (Bennett, Foster, and Chapman, 1990; covery area. Provided no complications develop,
Blomqvist and Stone, 1983; Bourn and Jenkins, most other patients do not require an airway. Patients
1992; Hasani, Pavia, Agnew, and Clarke, 1991; Hiet undergoing major thoracic surgery or cardiovascular
pas, Roth, and Jensen, 1974; Orlava, 1959). Pain surgery remain intubated and mechanically ventilated
medications are coordinated as needed with treat from several to 24 hours after surgery to minimize
ments to maximize treatment efficacy. the work of breathing and hence the work of the heart
In addition to goals related to oxygen transport, other to meet the metabolical demands of respiration.
important postoperative goals include the following: These patients are informed that artificial airway and
I. Maximize joint range of motion mechanical ventilation enables them to breathe more
2. Maximize muscle length and ligament integrity efficiently initially. A patient is also informed that he
with range of motion exercises or she will not be able to speak while the airway is in
3. Maximize patient's ability to perform activities place and may have a sore throat after its removal.
of daily living Patients are usually aroused and repositioned be
4. Maintain or increase general muscle strength fore leaving the operating room, although this is sel
and endurance dom remembered by patients. Not recalling the im
5. Maintain normal cognitive function to avoid mediate postoperative course is common. Patients are
disorientation and hospital-related psychoses. likely to be receiving some form of pharmacological
These goals are achieved with the prescription of analgesia (e.g., morphine). If blood was required in
general mobility exercise, including hip and knee traoperatively, whole blood, packed cells, or plasma
flexion and extension exercises and foot and ankle may still be infused in the immediate postoperative
exercises. These exercises are performed hourly re period or longer. Saline or other solutions are also in
gardless of whether the patient is sitting in the chair fused for regulation of fluid balance until the patient
or resting in bed. is able to drink and eat normally. Once vital signs
Finally, there are important preventative goals have stabilized, wounds are stable and not draining,
(e.g., minimizing the effects of restricted mobility and and the patient reasonably alert, the patient is trans
recumbency on all organ systems) (Chapters 17 and ferred to the ward. The patient is retained in the re
l8). Of particular concern in the surgical patient is the covery area should further monitoring be required. If
risk of thromboemboli and pulmonary emboli and the complications develop and oxygen transport and gas
risk of pressure points and skin breakdown. Thus mo exchange threatened, the patient may be transferred
bilization and regular activation of the muscle pumps to the intensive care unit.
to minimize circulatory stasis and frequent body-posi The physical therapist may be consulted to assess
tion changes are essential to reduce risks, which can and treat the patient as soon as he or she leaves the
have serious consequences for the patient's recovery. operating room or while in the recovery room. Most
Compression stockings are often put on the patient frequently the physical therapist sees the patient once
after surgery. These are not removed other than for he or she has been transferred to the ward and has
cleaning and redistributing pressure until the patient is been settled. The first 24 hours are critical.
consistently up and about. These stockings facilitate The risk of cardiopulmonary complications is
venous return and increase blood flow and velocity, greatest during the perioperative period and dimin
thereby minimizing the risk of thrombus formation. ishes as the patient becomes increasingly upright and
Should thrombus formation be suspected, an intermit mobile. Atelectasis and aspiration after extubation are
tent compression device may need to be attached to significant risks for the patient who has been intu
the legs to simulate muscle pump action. bated. The goal immediately after extubation is to
Not all patients who have surgery are intubated. promote optimal alveolar ventilation, maximize lung
Those that are, with the exception of patients under volumes and capacities (especially FRC), minimize
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504 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
closing volumes, and maximize expiratory flow rates There are several factors that are particulary im
and hence cough effectiveness. Areas most suscepti portant in surgical patients that can affect their sensi
ble to atelectasis are those that may have been physi tivity to narcotic analgesics, such as morphine
cally compressed during surgery (e.g., the left lower (Gilman, Goodman, and Gilman, 1990: Malamed,
lobe of the cardiovascular surgical patient and areas 1989). First, there is considerable intersubject re
adjacent to a lobectomy or segmentectomy). sponse variability to these agents. Second, older pa
Surgery constitutes a significant insult to the body. tients can be expected to be more sensitive to nar
After the trauma of surgery, anesthesia, sedation, cotics. Three, diverse multisystem pathology has a
fluid loss, incisions, and the significant energy re significant effect on the degradation, absorption, bio
quirements for healing and repair, patients can be ex transformation, and excretion of morphine. Four, ex
pected to be lethargic and difficult to arouse. The re aggerated effects of morphine have been reported
laxed state induced by anesthesia, sedation, and when administered in conjunction with other agents,
narcotics increases the risk of aspiration. This risk is such as other narcotic analgesics, phenothiazines,
exacerbated further in some patients by nausea and tranquilizers, or sedative-hypnotics; in addition, such
vomiting associated with anesthesia and narcotics. exaggerated effects have been reported in patients
Moving and positioning the patient upright whenever with respiratory depression, hypotension, and seda
possible and interacting with the patient stimulates tion and in patients who are unconscious. These situ
the reticular activating system making the patient ations in which exaggerated drug effects have been
more responsi ve and aroused. The increased meta reported are commonly encountered in the intensive
bolic demands that this requires, along with increased care setting and can result in unpredictable responses.
catecholamine release, helps overcome the residual Finally, the physical dependence and abuse potential
effects of anesthesia, sedation, and muscle relaxants of these agents cannot be ignored.
and their threat to oxygen transport, provided the de The physical therapist must be familiar with the
mands are not beyond the capacity of the oxygen patient's medications and the medication's indica
transport system to deliver oxygen. tions, side effects, and contraindications. The physi
Alternatively, some patients are restless and agi cal therapist can determine to what extent oxygen
tated after the effects of anesthesia have worn off. transport may be compromised by medication effects,
Hypoxemia can lead to restlessness and agitation. whether some recommendation needs to be made to
Thus it is important that these patients are not inap minimize untoward drug effects on arousal or some
propriately sedated. This compounds their need for other factor that negatively affects oxygen transport
treatment while making them less able to cooperate and gas exchange. For example, although narcotics
with treatment simultaneously (Dripps and Waters, are excellent analgesics, they have widespread sys
1941; Ross and Dean, \989). temic effects including cardiopulmonary depressant
At the outset of any treatment, the patient must be effects, gastrointestinal depressant effects, and mus
aroused as much as possible to cooperate fully and cle relaxant effects-all of which compromise oxy
derive the maximal benefit from treatment. The phys gen transport. Thus consideration needs to be given
ical therapist interacts continuously with the patient regarding whether other forms of analgesia can be
to arouse the patient fully, maintain arousal, stimulate used. Have nonpharmacological means of analgesia
normal cognitive function and orientation, and elicit been exploited? If pharmacological analgesia is indi
feedback from the patient to assess the response to cated, can analgesics other than narcotics be used? Or
treatment. Narcotics depress respiratory status and at least, can the dose of narcotic be reduced so that
arousal, and these effects are accentuated in patients satisfactory pain control can be achieved in combina
whose metabolic states have been disrupted with ill tion with nonpharmacological interventions?
ness and in older persons. Thus the physical therapist Mobilization in the upright position coordinated
must be vigilant in detecting untoward residual ef with breathing control and supported coughing ma
fects of narcotics in the surgical patient. neuvers is encouraged immediately after the patient is
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28 Acute Surgical Conditions 505
first aroused after surgery, unless contraindicated, to cilitate frequent turning. Cycle pedals can be adapted
help reverse and mitigate reduced arousal, atelectasis, to chairs and recumbent exercise in bed if necessary.
FRC, and impaired mucociliary transport associated Patients whose positioning is restricted with fixation
with surgery. Mobilization augments cardiopul and traction devices require hand, wrist, or ankle
monary function (see Chapter 1 7) particularly when weights, and possibly pulleys and other devices, to
the patient is upright (Levine and Lown, 1952; maintain muscle strength and power. Movements per
Lewis, J 980). These beneficial effects are enhanced formed with moderately heavy weights for multiple
by improved three-dimensional chest wall motion, sets (e.g., three sets of 10 repetitions) develop muscle
improved gut motility, and reduced intraabdominal strength. Movements performed with lighter weight
pressure. Extremity movement during ambulation in for multiple sets (e.g., 5 to 10 sets of 10 repetitions)
creases alveolar ventilation, enhances ventilation and tend to develop endurance and aerobic capacity. Be
perfusion matching by increasing zone 2 of the lungs, cause of the restrictions imposed by these devices,
and optimizes diffusing capacity. The upright posi maintaining joint range is essential (i.e., of the neck,
tion is essential such that the spine is erect, upper spinal column, and chest wall, as well as the extremi
body musculature relaxed, and the chest wall sym ties). The rotation component of joint movement is
metrical. Slouching and leaning particularly to the af readily compromised, thus this needs to be an integral
fected side reduces alveolar ventilation and con component of joint range of motion exercises. Propri
tributes to uneven distribution of ventilation and oceptive neuromuscular facilitation (PNF) move
areas of atelectasis (Bake, Dempsey, and Grimby, ments of the extremities can be beneficial. PNF
1976; Don, Craig, Wahba, and Couture, 1971; Glais movements of the chest wall can be coordinated with
ter, 1967). In addition, if this abnormal posture is breathing control and supported coughing maneuvers.
maintained, mucociliary transport of the area is im Upper body and trunk mobility and strengthening are
paired and mucus collects and stagnates, increasing important goals particularly in the patient with chest
the risk of bacterial colonization and infection. Sym wall incisions. The prescription is progressed gradu
metrical posture is monitored at a] I times (i.e., during ally in the patient with a chest wall incision, particu
ambulation, sitting at bedside, bed mobility exercises, larly in the patient with a median sternotomy who is
sitting up in bed, and lying in bed). Slouching and fa usually restricted to unresisted, upper-extremity mo
voring the affected side will lead to cardiopulmonary bility exercises in the first several weeks.
complications and possibly musculoskeletal compli Prescription of body positioning is essential in the
cations in the short and long term. management of the surgical patient for two reasons.
Mobilization and active exercise in upright pos First, without direction, the patient will tend to as
tures whenever possible are prescribed based on the sume a deleterious body position (i.e., maintaining a
need to enhance multiple steps in the oxygen trans restricted number of body positions that favor the af
port pathway (Dean and Ross, 1992; Ray et aI., fected side for prolonged periods of time with mini
1974). The priority is to perform as much activity as mal movement and "stirring up"). Thus once the ef
possible out of bed ancl upright (i.e., ambulation, fects of mobilization have been exploited in a given
transferring, sitting upright in a chair, and chair exer treatment session, body positions are prescribed for
cises with or without hand weights or exercise "between-treatment" times that continue to enhance
bands). When in bed, similar devices can be used, in oxygen transport for a given patient and discourage
cluding a monkey bar to facilitate moving in bed for excessive time in deleterious body positions. When
patients other than cardiovascular thoracic patients not ambulating, patients are encouraged to assume a
(e.g., the orthopedic patient with extremity fractures wide range of body positions (e.g., semi-prone) be
and traction). In addition, the use of the monkey bar tween treatments, as frequently as possible, (i.e., at
to perform repetitive bouts of exercise to maintain least every I to 2 hours) (Dean, 1985; Douglas, Re
upper-extremity strength and some general endurance hder, Beynen, Sessler, and Marsh, 1977; Piehl and
capacity, to relieve pressure and stiffness, and to fa Brown, 1976; Remolina, Khan, Santiago, and Edel
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506 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
FIGURE 28-1
Incentive spirometers.
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28 Acute Surgical Conditions 507
man, 19S I; Ross and Dean, 1992; Zack, Pontoppidan, mizing FRC, reducing closing volume, maximizing
and Kazemi, 1974). expiratory flow rates, promoting mucociliary trans
Alveoli are likely to remain patent for I hour after port, promoting airway clearance, optimizing lym
reinflation. Thus to sustain alveolar inflation and nor phatic drainage, minimizing the effects of increased
mal FRC, mobilization and body positioning coordi thoracic blood volume, maintaining fluid-volume
nated with breathing control and supported coughing regulating mechanisms, and minimizing the work of
must be carried out frequently (i.e., every I to 2 breathing and of the heart. Sustained maximal inspi
hours) to maintain optimal alveolar volume and dis ration is one intervention that promotes alveolar ex
tribution of ventilation. Maximal inspiratory maneu pansion. Each deep breath is performed to maximal
vers are coordinated with mobilization and body po inspiration to total lung capacity with a 3- to 5-sec
sitioning at \east every hour as tolerated. Maximal ond breath hold. This maneuver may reduce pul
inspiratory maneuvers alone, however, are unlikely to monary complications by promoting alveolar infla
be effective because the inspiratory pressure may be tion and gas exchange. The patient is encouraged to
insufficient to inflate atelectatic alveoli. Rather patent repeat this maneuver several times hourly, and fre
alveol i will tend to be overexpanded. Mobilization quently during mobilization, and before, during, and
and body positioning will directly alter the in after body-position changes.
trapleural pressure gradient and thereby optimize Incentive spirometry can be useful in patients who
alveolar expansion (Roussos et at. 1977). are resistant or unable to cooperate fully with maxi
Normal passive expiratory efforts to end tidal mal inspiratory efforts (Figure 2S-I ). Postoperative
volume are encouraged and maximal or forced expi hypoxemia may be reduced with this technique,
ratory efforts are usually avoided to prevent airway which uses the principle of sustained inspiration
closure and potential increase of atelectasis (Has ani using a feedback device (either flow or volume feed
et aI., 1991; Hietpas et aI., 1974; Nunn, Coleman, back) to achieve maximal inflating pressure in the
Sachithanandan, Bergman, and Laws, 1965). Huff alveoli and maximal inhaled volume. The incentive
ing (glottis open) rather than coughing (glottis spirometer can be used independently by the patient.
closed) also minimizes airway closure. There is less This technique ensures that each inspiration is physi
risk of bronchospasm than with coughing in which ologically optimal and is reproduced precisely from
the glottis is closed, transpulmonary pressure is in one inspiration to the next. Patients who are surgical
creased, and a compressive phase is involved. If in risks can benefit from being taught the use of the in
dicated, coughing maneuvers are most effective in centive spirometer during preoperative teaching by
the sitting or slightly lean-forward position in which the physical therapist to promote better inflation of
lung volumes and forced expiratory flow are maxi the lungs with incentive spirometry postoperatively.
mized and the respiratory muscles are mechanically The patient continues with a regimen of breathing
advantaged with respect to the length-tension char control and coughing maneuvers until full mobility
acteristics of the muscle fibers. Airway closure is and activities of daily living are resumed.
position-dependent (Chapter IS); therefore the de The application of intermittent positive pressure
gree of expiration encouraged by the physical thera breathing (IPPB) appears to be less effective for the
pist should be based on the patient's body position. postoperative patient than previously believed. The
Airway closure is potentiated in patients who are details of this modality are described in Chapter 41.
older, smoke, or are obese and in patients who are in
horizontal as opposed to upright body positions.
SUMMARY
M obilization and body posi tioning coordinated
with breathing control and supported coughing ma This chapter reviews the management of cardiopul
neuvers offer the greatest benefit to oxygen transport monary dysfunction secondary to acute surgical con
in the postoperative patient. Specific benefits are de ditions. Surgery and its physiological effects are de
scribed in Chapters 17 and IS. They include maxi scribed. Special reference is made to two specialized
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508 PART IV Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Acute Cardiopulmonary Conditions
types of surgery that have the greatest impact on car Bennett, W.D., Foster, W.M., & Chapman, W.F. (1990). Cough
enhanced mucus clearance in the normal lung. journal of Ap
diopulmonary function, namely, thoracic and cardio
plied Physiology. 69, 1670-1675.
vascular surgery.
Blomqvist, e.G., & Stone, H.L. (1983). Cardiovascular adjust
The four categories of factors contributing to or ments /0 graviratiollal stress. Handbook ofphysi()lo y (Vol. 2).
threatening oxygen transport are described in Chapter Washington, DC: American Physiological Society.
16. These factors include pathology, restricted mobil Bourn, J., & Jenkins, S. (1992). Post-operative respiratory physio
ity and recumbency, extrinsic factors related to the therapy. Indications for treatment. Physiotherapy, 78, 80-85.
Dean, E. (1985). Effect of body position on pulmonary function.
patient's care, and intrinsic factors related to the pa
Physical Therapy, 65, 613-618.
tient. This chapter examines in detail those extrinsic Dean, E., & Ross, J. (1989). Integrating current literature in the
factors related to surgery and anesthesia, and the im management of cystic fibrosis: a rejoinder. Physiotherapy
ular patients. For specific examples of patient treat capacity and the effects of posture. Anesthesiology, 35, 582-590.
ment prescriptions refer to the companion Douglas, W.W., Rehder. K., Beynen, F.M .. Sessler, A., D., &
Marsh, H.M. (1977). Improved oxygenation in patients with
workbook Clinical case studies i n cardiopulmonary
acute respiratory failure: the prone position. American Review
physical therapy. oJ Respiratol), Disease, //5,559-566.
Dripps. RD., & Waters, R.M. (1941). Nursing care of the surgical
patient. I. The "stir-up." American .lournal of Nursing, 4/, 53-34.
REVIEW QUESTIONS Dull,1. L., & Dull, W.L. (1983). Are maximal inspiratory breathing ex
ercises or incentive spiromeny betler than early mobilization after
1. Describe the physiological effects of surgery in cardiopulmonary bypass surgely? Physical Therapy, 63, 655-659.
cluding the specific surgical procedure, the type, Dureuil, B., (Viires, N., & Cantineau, J.P. (1986). Diaphragmatic
depth and duration of anesthesia, sedation, types contractility after upper abdominal surgery. journal oJ Applied
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28 Acute Surgical Conditions 509
Hietpas, B,G" Roth, RD, & Jensen. W,M. (1974), Huff coughing Ray, R, F" Yost, L, Moallem, S., Sanoudos, G,M., V illamenn,
and patency, Respiratory Care, 24, P., & Paredes, R.M. (1974), Immobility, hypoxemia, and
Leaver, H" Conway. JR, & Holgate, S,T, ( The incidence pulmonary shunting, Archi ves of Surge ry, 109,
of post-operative hypoxaemia following and pneu 537-54 L
monectomy: a pilot study, PhysiOlherapy, 80. 1-527, Remolina, Khan, A.U" Santiago, T.V" & Edelman, N.H,
Levine, RD, (l984), Anesthesiology, A manual for medical slu (1981), Positional hypoxemia il) unilateral lung disease, New
dents. Philadelphia: 1.8. Lippincott Co, England Journal of Medicine. 523-525,
Levine, S,A" & Lown, B, (1952), 'Armchair' treatment of acute Ross, 1., & Dean, E, (1989), Integrating physiological principles
coronary thrombosis, Journal of Ihe American Medical As soci into the comprehensive management of cardiopulmonary dys
arion, 148, 1365-1369, function, Physical Therapy, 69, 255-259,
Lewis, F.R. (1980), Management of atelectasis and pneumonia, Ross, L & Dean, E, (1992), Body positioning, In CC Zadai (Ed,),
Surgical Clinics of North America, 60, 1391-1401, P u lmo ll ary mana gement in physical Iherapy, N e w York:
Malamed, S,F, ([989), Sedation, A g uide 10 palielll manag ement Churchill Livingstone,
(2nd ed,) 51. Louis: Mosby, Roussos, CS" Fixley, M" Geriest, 1., Cosio, M" Kelly, S" Martin,
Muller, N" Volgyesi, G" Becker, L, Bryan. MR, & Bryan, A. C. KR, & Engel. LA. (1977), Voluntary factors influencing the
(979), Diaphragmatic muscle tone. Joum al of Applied Physi distribution of inspired gas, American Rev ie w of Respiratory
ology, 279-284. Disease, 116,457-467,
Nuon, 1,F. (1989),The influence of anesthesia on the respiratory sys Seaton, D" Lapp, N,L, & Morgan, W,K,c' (1979), Effect of
tem, In K Reinhart & K Eyrich, Clinical aspect of 02 body position gas exchange after thoracotomy, Thorax,
transport tissue oxygenation, New York: Springer-Verlag, 5l8-522,
Nunn, lE, Coleman, AJ" Sachithanandan, T, Bergman, N,A" & Sutton, P,P" Pavia, D" Bateman, J.R,M" & Clarke, S.W. (1982),
Laws, J,W, (1965), Hypoxaemia and atelectasis produced by Chest physiotherapy-a review, European Journal of Respira
forced expiration. Bri tish Journal of A naesthes ia, 3-12, tory Disease, 63. 188-20 I,
Orlava, OE (1959), Therapeutic physical culture in the complex Zack, M,B" Pontoppidan, H., & Kazemi, H. (1974), The effect of
treatment of pneumonia. Physical Therapy Review, 39, 153-160, lateral positions on gas exchange in pulmonary disease, Ameri
Piehl, M,A, & Brown, R,S, (1976), Use of extreme position changes can Review of Respiratory D isease, I/O, 149-153,
in acute respiratory failure, Crilical Care Medicine, 4, 13-14,
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PAR T V
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Chronic Primary Cardiopulmonary
Dysfunction
Elizabeth Dean
Donna Frownfelter
INTRODUCTION
there is no clear line between obstructive and restric
The purpose of this chapter is to review the pathophys tive patterns of lung disease, pathology can be gener
iology, medical management, and physical therapy ally defined based on the primary underlying patho
management of chronic, primary, cardiopulmonary physiological problems. Thus the primary conditions
pathology. Because the heart and lungs are interdepen that are presented include obstructive lung disease
dent and function as a single unit, primary lung or (i.e., chronic airflow limitation, asthma, bronchiecta
heart disease must be considered with respect to the sis, and cystic fibrosis) and restrictive lung disease
other organ and in the context of oxygen transport (i.e., interstitial pulmonary fibrosis). Lung cancer,
overall (Dantzker, 1983; Ross and Dean, 1989; Scharf which has the characteristics of both obstructive and
and Cassidy, 1989; Wasserman and Whipp, 1975). restrictive patterns of patho.logy, is also presented.
The long-term cardiopulmonary management of The long-term cardiopulmonary management of
chronic lung diseases is presented first. Although heart disease is then presented with special attention
513
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514 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
to angina, myocardial infarction, and valvular heart breathing re s ponse to vertilatioll-perfusion imbalance
disease. Chronic vascular diseases, including periph and hypoxemia, and tissue defenses against elastase.
eral vascular disease, hypertension, and diabetes, are Decline in pulmonary function and rate of devel
also presented. opment of the syndrome depend on the combination
The principles of management of the various of causative factors and individual responses to them.
chronic primary cardiopulmonary conditions are pre
sented rather than treatment prescriptions, which can
Chronic Bronchitis
not be discussed without consideration of a specific
patient. (For specific examples of patient treatment
Pathophysiology and medical management
prescriptions refer to the companion test Clinical case Chronic bronchitis is usually associated with a his
studies in cardiopulmonGl)1 physical therapy.) In this tory of smoking and is defined as mucous hyper
context the goals of long-term management of each secretion and cough producing sputum for three
condition are presented, followed by the essential months or more over a two-year period (Murray and
monitoring required, and the primary interventions for Nadel, 1988a). Over the first few years of smoking,
maximizing cardiopulmonary function and oxygen reversible airways changes occur. Over 10 to 15
transport. The selection of interventions for any given years of smoking, mucous hypersecretion and chronic
patient is based on the physiological hierarchy. The bronchitis become apparent. After 25 to 35 years of
most physiological interventions are exploited first smoking, irreversible airway damage and chronic dis
followed by less physiological interventions and those ability occur. Smoking is the major cause of lung
whose efficacy is less well documented (Chapter 16). cancer. The pathophysiology of chronic bronchitis is
reviewed in detail in Chapter 29.
The patient is prone to infection and repeated peri
PRIMARY PULMONARY DISEASE
ods of morbidity. Deterioration of aerobic capacity
OBSTRUCTIVE PATTERNS and functional capacity is related to the severity of
the condition. Nutrition and hydration may be im
Chronic Airflow Limitation
paired particularly in severe cases because of neglect
Chronic airflow limitation is a descriptive term that and the excessive energy cost of activities of daily
refers to those disorders that previously have been living. Sleep may be irregular, thus the patient's
termed chronic obstructive pulmonary disease (e.g., symptoms are worsened (e.g., reduced endurance, fa
chronic bronchitis, emphysema, bronchiectasis, and tigue, and lethargy) because of lack of normal physi
cystic fibrosis). Although there may be a reversible ological restoration from sleep.
component, airflow obstruction associated with these The natural history of chronic bronchitis related to
disorders is largely irreversible. The pathophysiology smoking includes mucous hypersecretion, reduction in
of these conditions is reviewed in detail in Chapter 29. forced expiratory volume (FEV), and increased hetero
Bates (1989) described the syndrome of chroruc air geneity of the distributions of ventilation, perfusion,
flow limitation as being caused by four external fac ventilation-perfusion matching, and diffusion (West,
tors, mediated by four primary tissue responses, and 1987). General debility and deconditioning ensue.
modified by four physiological responses. The princi Smoking contributes to increased mucous produc
pal external causative factors include inhaled irritants, tion in the small airways, increased mucus in the large
allergens, infectious, and climate. The four principal airways, respiratory bronchiolitis, reduced elastic re
tissue responses include large airway changes, small coil, increased airway reactivity, and vascular changes
airway changes, airway hyperreactivity, bronchiolar (Bates, 1989). These changes, lead to nonuniformity
damage, and alveolar destruction. The principal physi of time constants in the lung, with consequent inho
ological responses include a reversible increased air mogeneous distribution of inspired gas and premature
way reactivity component, pulmonary vascular re small airway closure, and to nonuniformity of ventila
sponse to alveolar hypoventilation, control of tion, perfusion, and diffusion distributions. Although
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29 Chronic Primary Cardiopulmonary Dysfunction 515
vaJiable among smokers, pulmonary function changes crease the demand on the left heart to maintain cardiac
generaHy corrcspond to the amount smoked and dura output. Similar to right-sided failure, the left heart
tion of the smoking history. Over time, the pulmonary may become hypertrophied, and over time, may fail.
function profile becomes increasingly consistent with The significantly increased intrathoracic prcssures
chronic airflow limitation (i.e., reduced FEY, and re generated during chronic coughing reduce venous re
duced FEY,IFYC), however, these are late indicators turn, cardiac output, and coronary perfusion and in
of pulmonary changes. Signs of uneven distribution of crease blood pressure. These effects exert additional
ventilation and increased closing volumes, indicative myocardial strain, lead to arterial desaturation, and
of small airway involvement, are early pulmonary increase the potential for cardiac dysrhythmias.
function changes in smokers. Exercise diffusing ca The complications of chronic bronchitis are exacer
pacity is reduced which explains in part the reduced bated by cardiopulmonary deconditioning. Despite the
maximal Y02 of smokers. Dynamic compliance with pathology, the efficiency of oxygen transport along the
breathing frequency is also reduced. Residual volume steps in the pathway is suboptimal. This reduced effi
is increased as a percent of total lung capacity. Tra ciency increases the oxygen demands of the patient
cheal mucous velocity is reduced and secretion clear overall who is unable to adequately supply oxygen.
ance is impaired. Any patient with a smoking history, Pharmacological support in the tong-term manage
regardless of a diagnosis, has some degrcc of chronic ment of chronic bronchitis includes bronchodilators
airflow limitation, which must be considered when (e.g., oral, metered-dose inhalant, inhaled powdered, or
these patients are receiving medical or surgical care. aerosol), corticosteroids (e.g., oral or inhaled), expecto
The cardiac manifestations of chronic bronchitis rants, antibiotics, inotropic agents (e.g., digitalis), beta
stem from airway obstruction, secretion accumulation blockers, antidysrhythmic agents, and diuretics. Patients
and reduced capacity to effectively expectorate, poly with chronic lung disease must be monitored closely
cythemia, low arterial oxygen tensions, and cardiopul during exercise given the potential cardiac effects of
monary deconditioning. Increased airway resistance disease and medications (e.g., beta-blocker agents atten
secondary to obstruction increases oxygen demand uate the normal hemodynamic responses to exercise and
and hence the work of breathing. This increased de bronchodilators, such as ventolin, elicit tachycardia).
mand is superimposed on an oxygen transport system
Principles of physical therapy management
that is already compromised. The cardiovascular sys
tem attempts to compensate for chronically reduced The goals of long-term management for the patient
arterial oxygen tension by increasing cardiac output with chronic bronchitis include the following:
(i.e., stroke volume and heart rate). As blood gases de • Maximize the patient's quality of life, general
teriorate, the production of red blood cells increases health, and well-being and hence physiological
(i.e., polycythcmia) to enhance the oxygen-carrying reserve capacity
capacity of the blood. However, polycythemia in • Educate about chronic bronchitis, self-manage
creases the viscosity of the blood, and in turn, the ment, effects of smoking, nutrition, weight con
work of the heart to pump blood to the pulmonary and trol, smoking reduction or cessation, other life
systemic circulations. Furthermore, viscous blood is style factors, medications, infection control, and
prone to circulatory stasis and clotting. role of a rehabilitation program
Low arterial oxygen tensions lead to hypoxic pul • Facilitate mucociliary transport
monary vasoconstriction and increased pulmonary • Optimize secretion clearance
vascular resistance (i.e., pulmonary hypertension). • Optimize alveolar ventilation
This also increases the work of the right heart in eject Optimize lung volumes a n d capacities a n d
ing blood to the lungs. Chronic overwork of the right flow rates
ventricle leads to hypertrophy, insufficiency, and • Optimize ventilation and perfusion matching
eventual failure of the right heart (cor pulmonale). and gas exchange
Chronically reduced arterial oxygen levels can in • Reduce the work of breathing
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516 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
• Reduce the work of the heart health practices (e.g., smoking reduction and cessation,
• Maximize aerobic capacity and efficiency of cold and flu prevention, flu shots, aerobic exercise,
oxygen transport strengthening exercises, nutrition, weight control, hy
• Optimize physical endurance and exercise ca dration, pacing of activities, energy conservation, re
pacity laxation, and stress management). Chronic bronchitis
• Optimize general muscle strength and thereby and emphysema are often associated with sleep distur
peripheral oxygen extraction bances. Obstructive sleep apnea is increasingly preva
Patient monitoring includes dyspnea, respiratory lent with disease severity. Thus activity and sleep pat
distress, breathing pattern (depth and frequency), ar tems need to be assessed to ensure sleep is maximally
terial saturation, cyanosis (delayed sign of desatura restorative and is not contributing to the patient's
tion), heart rate, blood pressure, and rate pressure symptoms. Integral to an exercise prescription is the
product. Patients with cardiac dysfunction or low time of day. Exercise is prescribed when the patient is
arteral oxygen tensions require ECG monitoring, par least fatigued, most energetic, and when performing
ticularly during exercise. If supplemental oxygen is such a program is most convenient.
used, the FIo2 administered is recorded. Subjectively, Aerobic exercise is an essential component of the
breathlessness is assessed using a modified version of long-term management of the patient with chronic
the Borg scale of perceived exertion. bronchitis to optimize the efficiency of oxygen trans
Medication that is needed to maximize treatment POit overall and mobilize and remove secretions (Old
response is administered before treatment (e.g., bron enburg, Dolovich, Montgomery, and Newhouse, 1979).
chodilators). Knowledge of the type of medication,
its administration route, and time to and duration of
Emphysema
peak efficacy is essential if treatment is to be maxi
Pathophysiology and medical management
mally efficacious.
The primary interventions for maximizing car Emphysema is associated with a prolonged history
diopulmonary function and oxygen transport in pa of smoking and chronic bronchitis and indicates sig
tients with chronic bronchitis include some combina nificant irreversible lung damage. A less common
tion of education, aerobic exercise, strengthening type of emphysema not associated with smoking is
exercises, chest wall mobility exercises, range of mo alpha-antitrypsin deficiency. Antitrypsin is essential
tion, body positioning, breathing control and coughing in balancing elastin production and degradation and
maneuvers, airway clearance techniques, relaxation, in preserving optimal lung parenchymal compliance.
activity pacing, and energy conservation. An er A deficiency of antitrypsin reduces lung elasticity
gonomic assessment of the patient's work and home and contributes to the characteristic increase in lung
environments may be indicated to minimize oxygen compliance that is the hallmark of emphysema. The
demand and energy expenditure in these settings. pathophysiology of emphysema is presented in detail
The use of supplemental oxygen depends on the in Chapter 4. The principal pathophys iological
severity of the disease. Some patients have no need for deficits include irreversible alveolar damage result
supplemental oxygen, some need it only during exer ing from loss of elastic recoil and the normal tether
cise, and some patients require continuous oxygen with i n g of t h e a l v e o l i, w h i c h renders t h e lung
proportionately more delivered during activity and ex parenchyma excessively compliant and floppy. Ex
ercise compared with rest. Supplemental oxygen is not cessi ve distension and' dil atation of the termi nal
usually required until lung damage becomes extreme bronchioles and destruction of alveoli reduces the
(i.e., the morphological changes are consistent with the surface area for gas exchange. Hence diffusing ca
irreversible changes associated with emphysema). pacity is correspondingly reduced. The dead space in
Education is a principal focus of the long-term the lungs and total lung capacity increase s ignifi
management of the patient with chronic bronchitis. Ed cantly. Breathing at normal tidal volume, the pa
ucation includes the reinforcement of preventative tient's airways close beyond that which normally oc
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29 Chronic Primary Cardiopulmonary Dysfunction 517
curs with aging, which contributes to ventilation and poxic vasoconstriction in the lungs. Over time, the
perfusion mismatch and hypoxemia. Time constants heart becomes enlarged and pumps even less effi
are altered such that alveolar units are not being ciently. In the long-term management of the patient
evenly ventilated. In its nonacute, chronic stages the with emphysema, alveolar ventilation, gas exchange,
primary problems include inadequate and inefficient reduced oxygen transport efficiency, and the work of
gas exchange resulting from the structural damage to breathing and of the heart are the primary pathophys
the lungs and altered respiratory mechanics of the iological problems. Unlike chronic bronchitis, secre
lungs, chest wall, and their interaction. The lungs are - tion accumulation may be less problematic in emphy
hyperinflated, the chest wall becomes rigidly fixed in sema patients during nonacute periods. Nonetheless,
a hyperinflated position, the normal bucket handle optimizing mucociliary transport is an ongoing con
and pump handle motions of the chest wall are im cern in that the consequences of mucous retention
paired, the hemidiaphragms are flattened, the medi and infection can be devastating.
astinal structures are shifted, and the heart is dis
Principles of physical therapy management
placed and rotated, making its function inefficient
(Bake, Dempsey, and Grimby, 1974; Geddes, 1984; The goals for long-term management of the patient
Murray and Nadel, 1988a). The normal mucociliary with emphysema include the following:
transport system is ineffective because years of • Maximize the patient's quality of life, general
smoking destroy the cilia, reduce their number, and health, and well-being and hence physiological
alter their configuration and orientation; thus their reserve capacity
function is correspondingly obliterated or impaired. • Educate about emphysema, self-management,
In addition, these patients are unable to generate smoking reduction and cessation, medications,
high transpulmonary pressures and forced expiratory nutrition, weight control, infection control, and
flow rates because of altered respiratory mechanics. the role of a rehabilitation program
Consequently, coughing maneuvers are weak and in • Optimize alveolar ventilation
effective. The administration of supplemental oxy • Optimize lung volumes and capacities and flow
gen is limited because these patients rely on their hy rates
poxic drive to breathe. This life-preserving drive can • Optimize ventilation and perfusion matching
be attenuated with even moderate levels of oxygen. • Reduce the work of breathing
Thus oxygen administration is limited to low flows. • Reduce the work of the heart
The respiratory muscles are often weak, if not fa • Maximize aerobic capacity and efficiency of
tigued (Rochester, and Arora, 1983). Overall, pa oxygen transport
tients with emphysema, particularly severe emphy • Optimize physical endurance and exercise ca
sema, tend to be inactive and deconditioned, which pacity
further compromises the efficiency of the oxygen • Optimize general muscle strength and thereby
transport system and the capacity of other steps in peripheral oxygen extraction
the pathway to compensate. • Optimize respiratory muscle strength and en
There are several physiological compensations durance and overall respiratory muscle efficiency
that occur in response to chronic hypoxemia. Stroke Education focuses on teaching the patient about
volume and cardiac output are increased. The red emphysema, self-management of the disease, the effect
blood cell count increases (polycythemia), however, of smoking and smoking cessation. nutrition, weight
the blood becomes more viscous and requires more control, hydration, relaxation, sleep and rest, stress
work to eject and distribute throughout the body. management, activity pacing, energy conservation, and
Thus the stroke work of the heart is further increased. prevention (e.g., cold and flu prevention, flu shots, aer
This load on the heart is additional to the increased obic exercise, diet, sleep, and stress management).
afterload on the right ventricle because of an increase Comparable with the patient with chronic bronchi
in pulmonary vascular resistance secondary to hy tis, sleep disturbances are common in the emphysema
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518 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
patient. Activity and sleep patterns are assessed to en anaerobic capacity, improved ventilatory muscle
sure sleep is maximally restorative. If obstructive strength and endurance, and increased motivation (Bel
sleep apnea is disturbing the patient's sleep, medical man and Kengregan, 1981; Belman and Wasserman,
intervention is required. 1981; Dean, 1993). Exercise intensity is prescribed
Patient monitoring includes dyspnea, respiratory based on rating of breathlessness (mod ified Borg
distress, breathing pattern (depth and frequency), ar scale) (Chapter 17), in conjunction with objective and
terial saturation, lightheadedness, discoordination, other subjective responses from the exercise test.
heart rate, blood pressure, and rate pressure product. Patients with chronic airflow limitation alter their
Patients with cardiac dysfunction or low arterial oxy breathing patterns so that they are breathing on the
gen tensions require ECG monitoring particularly most metabolically efficient portion of the pressure
during exercise. Subjectively, breathlessness is as relaxation curve (Chapter 4 and 29). These patients
sessed using a modified version of the Borg scale of tend to breathe with prolonged expiratory phases to
perceived exertion. maximize gas transfer and mixing in the lungs to
Medication that is needed to maximize treatment minimize the effects of altered ventilatory time con
response is administered before treatment (e.g., bron stants. To facilitate such a breathing pattern, the pa
chodilator). Knowledge of the type of medication, its tient tends to breathe through pursed lips, which may
administration route, and time to and duration of peak create back pressure to maintain the patency of the
efficacy is essential if treatment is to be maximally airways (Muller, Petty, and Filley, 1970). The meta
efficacious. When patients are on multiple medica bolical efficiency of the patient's breathing pattern
tions, the interactions and implications on treatment may be improved further by altering breathing me
response must be identified. chanics rather than imposing a different breathing
The primary interventions for maximizing car pattern that may be suboptimal. Altering breathing
diopulmonary function and oxygen transport in pa mechanics involves manipulating the patient's body
tients with emphysema include some combination of position to promote alveolar ventilation, perfusion,
education, aerobic exercise, strengthening exercise, and ventilation and perfusion matching.
ventilatory muscle training (strength and endurance) The increased intrathoracic pressures generated
or ventilatory muscle rest, low flow oxygen, mechan during chronic coughing limit venous return, cardiac
ical ventilatory support for home use, chest wall mo output, and coronary perfusion. Blood pressure is
bility exercises, range of motion exercises, body posi also increased. These effects exert additional myocar
tioning, breathing control and coughing maneuvers, dial strain, lead to arterial desaturation, and increase
airway-clearance techniques, relaxation, activity pac the potential for cardiac dysrhythmias. Breathing
ing, and energy conservation. An ergonomic assess control and coughing maneuvers coupled with body
ment of work and home environments may be indi positioning and exercise are instructed such that the
cated to minimize oxygen demands in these settings. work of breathing is minimized (i.e., alveolar ventila
The benefits of aerobic and strengthening exercise tion and gas transfer is as efficient as possible), and
in the long-term management of airflow limitation to coughing is also as efficient as possible (i.e., maxi-
optimize oxygen transport in patients with compro mally productive with the least energy expenditure).
mised oxygen delivery is well established (Dean, Physical therapy is one component of a compre
1 9 9 3 ; Niederman et aI., 1 9 91 ; R i e s , Ellis, and hensive rehabilitation program in the long-term man
Hawkins, 1988; ZuWallack, Patel, Reardon, Clark, and agement of emphysema. Such a program also needs to
Normandin, 1991). Patients with severe limitations are include information on health promotion and mainte
often unable to exercise at a sufficient intensity to ef nance, ongoing review and log of medications, respi
fect aerobic adaptations to the exercise stimulus. Bene ratory support (e.g., oxygen aerosol therapy, and me
fits of exercise in these patients may be explained by chanical ventilatory support), occupational therapy,
desensitization of dyspnea, improved movement effi sexual rehabilitation, psychosocial rehabilitation, and
ciency and hence movement economy, improved vocational rehabilitation (Dean, 1993; Murray, 1993).
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29 Chronic Primary Cardiopulmonary Dysfunction 519
Asthma
heart rate, blood pressure, and rate pressure product.
Pathophysiology and medical management
Patients with cardiac dysfunction or low arterial oxy
Asthma is a common respiratory condition that is gen tensions require ECG monitoring particularly dur
characterized hypersensitivity of the airways to exercise. breathlessness is assessed
various in reversible ob a modified version of the Borg scale of per
struction (i.e., and bronchial edema ceived exeltion.
1984; M urray a n d Nadel, I Medication that is needed to maximize treatment
(Chapter In mild cases, no treatment response is administered before treatment (e.g., bron
other than prophylaxis may be needed. In severe chodilators and antiinflammatories). Knowledge of
cases, asthma can be life Once af the type of medication, its administration route, and
fected by the the narrow, increas time to and duration of efficacy is essential if
treatment is to be maximally efficacious. When pa-
Breathing narrowed con- tients are on multiple their interactions
tributes to wheezing, reduced alveolar ventilation, and the for must be known.
rapid shallow shortness of breath, in The primary interventions for maximizing car
c reased work of brea t h i n g , des a t u r a t i o n , a n d diopulmonary function and oxygen in pa
cyanosis. Increased inhomogeneity o f the distribu tients with asthma include education, aerobic exer
tion of ventilation is present in some nonacute chest wall
asthmatic patients Dean, and Ab
boud, I Although some may ing, and stress management.
mucous hypersecretion, even normal amounts of E ducation is c e n t r a l to t of
pulmonary secretions can obstruct narrowed air asthma. The is the basic pathophysiol
ways leading to atelectasis. Asthma that has welI ogy of the disease and its Other central top
defined triggers is easier to manage than cases ics including preventative health practices are also
where the triggers are less specific. taught cold and flu flu med
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520 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
tient to the side effects of the and there is The patient with bronchiectasis has
vironment for exercise. Temperature and humidity reserve capacity and function
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29 Chronic Primary Cardiopulmonary Dysfunction 521
response is administered before treatment. Knowl Between exacerbations, the medical priorities are
edge of the type of medication, its administration to reduce the risk of infection and morbidity and pro
route, and time to and duration of peak efficacy is es mote optimal health, growth, and development.
sential if treatment is to be maximally efficacious.
Principles of physical therapy management
The primary interventions for maximizing car
diopulmonary function and oxygen transport in pa The goals of long-term management of the patient
tients with bronchiectasis include some combination with cystic fibrosis include the following:
of education, aerobic exercise, strengthening exer • Maximize the patient's quality of life, general
cise, chest wall mobility exercises, range of motion health and well-being, growth and development,
exercises, body positioning, breathing control and and physiological reserve capacity
coughing maneuvers, airway clearance interventions, • Educate the patient and family about cystic fibro
optimizing rest and sleep, relaxation, pacing, and en sis, self-management, nutrition, prevention of acute
ergy conservation. An ergonomic assessment of the exacerbations of the disease, infection control, and
patient's work and home environments may be indi medication's uses, modes of adi
m nistration,
cated to maximize function in these settings. macokinetics and times to peak efficacies.
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522 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
tion of education, aerobic exercise, strengthening ex drainage can be integrated into breathing control.
ercise, ventilatory muscle training (strength and en This procedure focuses on eliciting coughing when
durance), ventilatory muscle rest, supplemental oxy it will be most productive, thereby minimizing less
gen, mechanical ventilation for home use, chest wall productive, exhaustive coughing. Patients with cys
mobility exercises, range of motion exercises, body tic fibrosis often cough so violently and uncontrol
positioning, breathing control and coughing maneu lably that it leads to significant arterial desaturation,
vers, airway clearance interventions, relaxation, pac vomi ting, and exhaustion and impedes venous re
ing, and energy conservation. turn and cardiac output.
Education focuses on teaching preventative health Ventilatory devices such as the positive expiratory
practices and infection control (e.g., cold and flu, flu pressure (PEP) mask and the flutter valve have
shots, aerobic exercise, nutrition, hydration, relax shown benefit in some patients with CF with respect
ation, stress management, activity pacing, and energy to reducing airway closure, clearing secretions, and
conservation). enhancing gas exchange (Pryor, 1993; Webber and
Physical activity and aerobic exercise need to be Pryor, 1994). Such aids may be useful adjuncts in
integrated early into the life style of the child with some patients, however, they do not replace the mul
cystic fibrosis (Cystic Fibrosis and Physical Activ tiple benefits of physical activity and exercise on op
ity, International 10urnal of Sports Medicine, 1988; timizing oxygen transport including mobilizing and
Keens, Krastins, Wannamaker, Levison, Crozier, removing secretions.
and Bryan, 1977; Zach, Oberwaldner, and Hausler,
1992). As much as possible, the child is integrated
RESTRICTIVE PATIERNS
into activities of his or her peer group. A prescribed
Interstitial Lung Disease
aerobic exercise program is designed to optimize
Pathophysiology and medical management
the efficiency of oxygen transport at all steps in the
pathway and thereby enhance functional capacity The pathophysiology of restrictive lung disorders
overall. Physical activity and aerobic exercise en and interstitial lung disease (ILD) in particular is
hances mucociliary transport and mucociliary clear described in Chapter 4. This clasification of lung
ance, maximizes alveolar ventilation and ventila disease is associated with various occupations and
tion and perfusion matching, increases ventilatory the i n h a l a t i o n of i n o r g a n i c and organic dust
muscle strength and endurance and airway diame (Chung and Dean, 1989). As the disease pro
ter, and stimulates a productive effective cough. gresses, total lung capacity (TLC) and vital capac
Furthermore, physical activity and exercise have ity (VC) are reduced. Residual volume often re
been associated with improved immunity and re mains the same. Maximal flow rates tend to be
duced risks of infection (Pyne, 1994; Shephard, increased as compliance is reduced. The drive to
Verde, Thomas, and Shek, 1991). These are signifi breathe, breathing frequency, and the ratio of tidal
cant outcomes for patients with cystic fibrosis who volume to total lung capacity are increased. Glan
have thick copious secretions. dular hyperplasia may be present, leading to mu
In addition, breathing control and coughing ma cous hypersecretion in some patients. Diffusing ca
neuvers are included as a component of a long-term pacity may be reduced but may only be apparent
self-management rehabilitation program. Postural during exercise (i.e., art.erial desaturation and dys
drainage and manual techniques have been the pnea). Exercise-induced desaturation and reduction
mainstay of airway clearance in the past. Exercise, in Pa02 may also reflect shunt and ventilation and
however, has a primary role in secretion mobiliza perfusion mismatch (Jernudd-Wilhelmsson, Horn
tion and as an airway clearance intervention (Dean blad, and Hedenstierna, 1986).
and Ross, 1989). Breathing control and coughing Hemodynamic changes may be present (e.g., in
stategies are coupled with exercise to facilitate se creased pulmonary artery pressure). Chronically in
cretion clearance. The principles of autogenic creased pulmonary artery pressures and hence in
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29 Chronic Primary Cardiopllinl10nal Dysfunction 523
cessation, nutrition,
tion, medications and their uses, prevention, ation, activity
health promotion, and infection control During aerobic with interstitial
• Optimize alveolar ventilation lung disease are prone to arterial desaturation (Arita,
volumes and capacities Nishida, and 198 Patients who desatu
ventilation and perfusion matching rate during and
1985) require oxygen
The intensity of the exercise is defined by
• Reduce the work of the heart arterial breathlessness, and work of the
and efficiency of heart, in with other responses.
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524 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
If detected early, thoracic surgery may be per diac dysfunction or low arterial oxygen tensions re
fonned to excise the cancerous tumor (Chapter 28). If quire ECG monitoring. Subjectively, breathlessness
inoperable, or in the case of metastases, a patient may is assessed using a modified version of the Borg scale
be managed at home or in a hospice. Patients are de of perceived exertion.
bilitated, often undernourished, fatigued, short of Medication that is needed to maximize treatment
breath, lethargic, depressed, and in pain (Saunders response is administered before treatment (e.g., anal
and McCorkle, 1985). Although these patients are gesics or bronchodilators). Knowledge of the type of
often extremely ill, there is a growing trend to man medication, its administration route, and time to and
age these patients in the community whenever possi duration of peak efficacy is essential if treatment is to
ble. As the disease progresses, maintaining function be maximally efficacious.
and reducing the rate of deterioration become pri The primary interventions for maximizing car
mary goals. diopulmonary function and oxygen transport in pa
tients with lung cancer include some combination of
Principles of physical therapy management
education, mobilization, strengthening exercises,
The goals of long-term management of the medical chest wall mobility exercises, body positioning, sup
patient with lung cancer include the following: plemental oxygen, mechanical respiratory support,
breathing control and coughing maneuvers, airway
• Maximize the patient's quality of life, general
clearance interventions, sleep and rest, relaxation, ac
health, and well-being and hence physiological
tivity pacing, and energy conservation. Treatments
reserve capacity
are timed whenever possible to coincide with the pa
• Educate the patient and family about the bene
tients' peak times during the day.
fits of a palliative program
Patients with cancer may benefit frol11 the immuno
• Promote self-determination
logical effects, as well as oxygen transport effects of
• Provide supportive care
mobilization and physical activity (Calabrese, 1990).
• Optimize pain control
The prescriptive parameters are adjusted each session
• Facilitate mucociliary transport
given the rapid changes in these patients' conditions.
• Optimize scretion clearance
Patients with lung cancer often cough up and ex
• Optimize alveolar ventilation
pectorate blood in their sputum. The airways need to
• Optimize lung volumes and capacities and flow
be as clear as possible to avoid obstruction, atelecta
rates
sis, risk of infection, and pneumonia. Although air
• Optimize ventilation and pelfusion matching
way clearance is an important goal, treatments should
• Reduce the work of breathing
avoid contributing significantly to bleeding and blood
• Maximize aerobic capacity and efficiency of
loss if possible. This blood loss may contribute to
oxygen transpolt
anemia and fatigue.
• Optimize physical endurance and exercise ca
Manual airway clearance interventions may be in
pacity
dicated in some patients. Postural drainage may be
• Otimize general muscle strength and thereby pe
coupled with percussion and manual vibration. The
ripheral oxygen extraction
impact of manual interventions, however, may con
• Optimize the benefits of sleep and rest
tribute to bleeding; thus the patient requires stringent
• Minimize the effects of restricted mobility and
monitoring. Metastases to the thoracic cavity and the
recumbency
ribs in particular may preclude percussion in favor of
Patient monitoring includes dyspnea, respiratory manual vibration being petformed over nonaffected
distress, breathing pattern (depth and frequency), ar areas. Treatment duration may be limited by the pa
terial saturation, cyanosis (a delayed sign of desatura tient's tolerance. Tolerance may be improved by
tion), heart rate, blood pressure, and rate pressure modifying body position or by shortening treatments
product. Patients who can be mobilized but have car- but increasing their frequency.
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29 Chronic Primary Cardiopulmonary Dysfunction 525
presented in 28. In less severe cases, is general muscle strength and thereby pe
managed with medications (e.g., sublin oxygen extraction
and physical Patient monitoring includes hemodynamic moni
has stabilized, a 2TElaea-E�xer toring (i.e., heart rate, blood pressure, rate pressure
else tolerance test may be conducted under supervision product, and responses to treat
in a cardiac stress testing facility where l2-lead ECG ment, particularly exercise, should also be recorded
monitoring can be performed. The exercise (e.g., rating of Signs of
which the exhibits (i.e., the chest dyspnea, dizzi
and serve as the basis for n e s s, dis orientation, dis c oordination, cyanosis,
activity and exercise. coughing, and chest sound (i.e., a
The body position in which exercise is performed need to be monitored. is not an
is important in patients with heart disease. Positions symptom under any circurmstance. Should it occur,
of increase the volume of fluid shifted treatment is immediately and
to the central circulation. This in emergency measures instituted. Treatments will be
creases venous return and the work of the heart. Thus safer and more prescribed with continous
body positions are selected for these patients EeG Without ECG treat
to minimize cardiac work during exercise and when ments need to be conservative. If there is any doubt at
resting after exercise Wolfson, and any time about the of a
Cohen, Levine and 1952). and her or his ability to tolerate treatment safely, the
should be referred to a general practitioner or
PrinCiples 01 physical therapy management
cardiologist for clearance before being treated.
Patients may be referred to therapy with a Medication that is needed to maximize treatment
history of angina as a or as a prob response is administered before treatment. Knowl
lem. angina is managed with the same of the of medication, its administration
care and given it can be a route, time to as well as duration of efficacy is
condition. A patient for whom antianginal medication essential if treatment is to be maximally efficacious.
is prescribed must have the medication present. The For the long-term of angina, interven
medication must not have expired and must be within tions include some combination of education, aerobic
visible access during treatment. The thera chest wall
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526 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
activity and energy con jury and cell death Injured myocar
servation. Education includes information about heart dial cells either recover or die the healing
disease and risk factors smoking, diet, stress, period. Thus minimizing further damage and maxi-
weight, and being active in the during this 6-week period is crit
hot environments) and preventative strate ical. infarctions can range from
smoking reduction and low-fat silent and unnoticed by the patient to life
reduced alcohol comsumption, exercise, relax threatening. can occur in the my
ation, activity pacing, and stress management). ocardium but occur primarily in the ventricles. The
Patients with are at risk of an in- the greater the risk of ventricu
and monitor- acute edema, and left
are needed to detect or frank myocardial ventricular failure. Because myocardial ischemia
infarction. These patients are potentially hemody and infarction impair the pumping action of the
namically unstable; thus their re heart and thus cardiac output, patients tend to be
sponses during, and after treatment, and in need of oxygen. Even after the oxy
larly aerobic and should be gen has been discontinued and the has
monitored and recorded. Minimally, heart rate, healed, the patient may continue to be vulnerable
blood pressure, and rate pressure product should be hemodynamically. the myocardium will have
taken alonll with the some that will affect both the electrical ex
citability and the mechanical function of the heart.
In the may continue to have low
normal arterial blood gases. Hypoxemia is lethal in
that it and predisposes tissues
to must be avoided. Post
namic response. activity and aerobic exer myocardial infarction are usually dis-
cise are prescribed at a heart rate or per home on several medications (e.g., nitro
ceived exertion ranges that are below the anginal glycerin, calcium antagonists, beta-blockers, and di
threshold based on a tolerance text uretics). on the of
1 Peak exercise tests in cardiac usually continue to one or more of
,f'V"""""'"
that may elicit angina o r these medications over the long term. The need for
are performed i n a cardiac stress oxygen is usually short term and restricted to the
laboratory under the supervision of a s hospital stay.
The body position in which aerobic exercise is
Principles of physical therapy management
IS Important in with heart disease.
Positions of increase the volume of tluid After from hospital, many post myocardial
shifted from the periphery to the central circulation. infarction patients see a physical therapist either pri
This increases venous return and the work of the vately or through a cardiac rehabilitation program.
heart. Thus positions are selected for The majority of will remain on
these patients to minimize cardiac work exer rehabilitation program an exercise program
cise and during rest after exercise (Lanllou et for 6 to 12 months.
1977; Levine and Lown, 1952). Regardless of the setting, therapy in
cludes education, support, and a super
vised for safely and
Myocardial Infarction
confidence physical exertion. In addition, an
Pathophysiology and medical management
exercise program is specifica!Jy prescribed for the pa
frequently frank myocardial is tient to enhance oxygen transport up-
chemia and infarction. Myocardial ischemia is re and utilization at the tissue level)
whereas infarction denotes mvoeardial in the metabolic demand on the heart.
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29 Chronic Primary Cardiopulmonary Dysfunction 527
A GXTT is conducted before leaving the hospital Patient monitoring includes hemodynamic moni
or when the patient is enrolled in an exercise pro toring (i.e., healt rate, blood pressure, and rate pres
gram. The time between the exercise test and the ex sure product). Subjective responses to treatment, par
ercise prescription and implementation of the exer ticularly exercise, should also be recorded (e.g.,
cise program should be minimal. Peak (formerly Borg's rating of perceived exeI1ion). Angina is not an
referred to as maximal) exercise tests are conducted acceptable symptom under any circumstance. Should
in the presence of a cardiologist and provide the opti it occur, however, treatment is immediately discontin
mal basis for an exercise prescription. Submaximal ued and emergency measures instituted. Treatments
exercise tests can be conducted by the physical thera will be safer and more precisely presclibed with con
pist. These can provide the basis for an exercise pro tinuous ECG monitoring. Without ECG monitoring,
gram, however, the prescription is conservative com treatments need to be conservative. If there is any
pared with that based on a peak exercise test. The doubt at any time about the hemodynamic stability of
principles and practice of exercise testing are de a patient and her or his ability to tolerate treatment
scribed in Chapter 17, 23 and 24. Such testing is an safely, the patient should be referred to a general prac
art and an exacting science and should be carried out titioner for clearance before being treated.
in a rigidly standardized manner to ensure the test re Medication that is needed to maximize treatment
sults are maximally valid, reliable, and useful. response is administered before treatment (e.g., an
Comparable with the angina patient and not overt tiarrhythic agents). Knowledge of the type of medica
infarction, the following caution must be adhered to tion, its administration route, and time to and dura
with the patient who has a history of myocardial in tion of peak efficacy is essential if treatment is to be
farction. A patient jar whom antianginal medication maximally efficacious.
is prescribed must have the medication present. The The primary interventions for maximizing car
medication must not have expired and must be within diopulmonary function and oxygen transport in pa
visible access during treatment. The physical thera tients with myocardial infarction include some combi
pist should examine the medication before treatment nation of education, aerobic exercise, strengthening
to ensure that the expiratory date has not passed and exercises, chest wall mobility exercises, body position
to take responsibility for positioning the medication ing, breathing control and coughing maneuvers, relax
near the patient for access to it should the patient de ation, activity pacing, and energy conservation. An er
velop angina during treatment. gonomic assessment of b o th work a n d h ome
The goals of long-term management of the patient environments may be indicated to minimize myocar
with myocardial infarction include the following: dial strain.
• Maximize the patient's quality of life, general Education focuses on the teaching the basic patho
health, and well-being and hence physiological physiology of heart disease, its risk factors, and pre
reserve capacity vention. Health promotion practices are advocated
• Educate about myocardial infarction, self-man (e.g., smoking reduction and cessation, good nutrition,
agement, nutrition, weight control, smoking re weight control, hydration, quality rest, and sleep peri
duction and cessation, risk factors, disease pre ods). In addition, types of physical activity that im
vention, medications, life style, activities of pose undue myocardial strain, increase intrathoracic
daily living, and avoiding static exercise, strain pressure, and restrict venous return and cardiac out
ing, and the Valsalva maneuver put, such as heaving lifting, straining, or the Val salva
• Maximize aerobic capacity and efficiency of maneuver, are avoided. The patient is taught to moni
oxygen transpOlt tor and practice vigilance in monitoling his or her own
• Reduce the work of the heart condition (e.g., new signs of infarction). These pa
• Optimize physical endurance and exercise ca tients are potentially hemodynamically unstable and
pacity thus their hemodynamic responses before, dUling, and
• Optimize general muscle strength and thereby after treatments, particularly exercise, should be mon
peripheral oxygen extraction itored and recorded (i.e., heart rate, blood pressure,
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528 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
and rate pressure product should be taken, along with Prophylactic antibiotics against endocarditis are
their subjective responses to treatment). administered to most patients with significant valvu
Peak exercise tests in cardiac patients that may lar involvement and in mild disease before proce
elicit angina or ST -segment changes are performed in dures such as dental work.
a cardiac stress testing laboratory under the supervi
Principles of physical therapy management
sion of a cardiologist. The parameters of the exercise
prescription are set based on a peak exercise test. In The goals of long-term management of the patient
tensity is set within a heart rate, oxygen consumption, with valvular heart disease include the following:
and exertion range (e.g., 70% to 85%, of the anginal • Maximize the patient's quality of life, general
threshold) (Chapter 17). health, and well-being and hence physiological
Aerobic exercise of large muscle groups rather reserve capacity
than small muscle groups (e.g., arm ergometry) is se • Educate about cardiac valvular disease, self
lected to minimize the increased hemodynamic de management, nutrition, weight control, smoking
mand and strain and the increased work of the heart reduction and cessation, cardiac risk factors, dis
associated with this type of work. Hot and humid con ease prevention, medications, life style, activities
ditions also place additional stress on the heart, thus of daily living, and avoiding static exercise, strain
exercising under these conditions should be avoided. ing, and the Valsalva maneuver
The body position in which aerobic exercise is • Maximize aerobic capacity and efficiency of
performed is important in patients with heart disease. oxygen transport
Positions of recumbency increase the volume of tliud • Optimize physical endurance and exercise ca
shifted from the periphery to the central circulation. pacity
This increases venous return and the work of the • Reduce the work of the heart
heart. Thus upright body positions are selected for • Optimize general muscle strength and thereby
these patients to minimize cardiac work during exer peripheral oxygen extraction
cise and during rest after exercise (Langou et aI., Physical therapists are involved with the manage
1977; Levine and Lown, 1952; Prakash, Parmley, Dik ment of patients with valve defects medically, either
shit, Forrester, and Swan, 1 973). as a primary or secondary problem, and surgically.
After surgery, these patients progress well; the princi
ples of their management are presented in Chapter
Valvular Disease
28. With respect to the medical management of valve
Pathophysiology and medical management
defects, the goal is to optimize oxygen transport in
Valve dysfunction is either congential or acquired and the patient for whom surgery is not indicated either
may require treatment as a primary condition or is pre because the defect is not sufficiently severe or be
sent as a secondary condition. Any of the heart and cause the patient cannot or refuses to undergo
pulmonary valves may be affected. Rheumatic fever surgery. Although the mechanical defect cannot be
was a common cause of rheumatic heatt disease and in improved, oxygen transport may be improved with
particular mitral valve insufficiency (Goldberger, judicious exercise prescription in some patients. The
1990). Interconnecting lymphatic vessels between the parameters of the exercise prescription are usually
tonsils and the heart are thought to be responsible. Cal moderate in that inapprop'riate exercise doses can fur
cification of valves that impairs opening and closing is ther disrupt the inappropriate balance between oxy
another example of an acquired valve dysfunction. gen demand and supply and thus further exacerbate
Clinically, patients may present with exertional symptoms. In addition, there is the potential for fur
dyspnea, excessive fatigue, palpitations, fluid reten ther valvular dysfunction if the myocardium is me
tion, and orthopnea (Sokolow, McIlroy, and CheitJin, chanically strained.
1990). These sypmtoms are often relieved when exer The goal of the aerobic exercise prescription is to
tion is discontinued. identify the exercise dose that will optimize the effi
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29 Chronic Primary Cardiopulmonary Dysfunction 529
ciency of other steps in the oxygen transport pathway pain, lightheadedness, dizziness, disorientation, dis
such that the available oxygen delivered to the pe c o o r d i n a tion, c y a n o s i s , c ou g h i n g , chest s o u n d
ripheral tissues is maximally used without constitut changes (i.e., a gallop) need t o b e monitored. Treat
ing a significant mechanical strain on the heart. Max ments will be safer and more precisely prescribed
imizing work output over time is the goal. Thus the with continuous ECG monitoring. Without ECG
severely compromised patient will perform a signifi monitoring, treatments need to be conservative. If
cantly greater volume of functional work over time there is any doubt about the hemodynamic stability of
with short, frequent sessions of exercise rather than a patient and her or his ability to tolerate treatment
longer, less-frequent sessions. safely, the patient should be referred to their general
If the valve defect is a secondary problem, the practitioner for clearance before being treated.
physical therapist must assess the severity of the de The primary interventions for maximizing car
fect and its functional consequences. The following diopulmonary function and oxygen transport in pa
questions must be addressed: tients with cardiac defects include some combination
I. Does the defect preclude treatment? of education, aerobic exercise, strengthening exercises,
2. Does the defect require that treatment be modi chest wall mobility exercises, body p ositioning,
fied, if so, how? breathing control, coughing maneuvers, relaxation, ac
3. What special precautions should be taken? tivity pacing, and energy conservation. An ergonomic
4. What signs and symptoms would indicate the assessment of both work and home environments may
patient is distressed? be indicated to minimize myocardial strain.
5. What parameters should be monitored? Exercise prescription for patients with valvular heat1
6. Is the patient taking medications as prescribed? disease is modified to ensure that the energy demand is
How might these medications alter the patient's commensurate with oxygen supply. Otherwise, exces
response to treatment? sive oxygen demand will worsen the patient's response
7. Is there any evidence of heart failure? If so, to physical activity, lead to further distress, and possi
what will the effects of exercise be? bly reduced functional capacity. Aerobic exercise of
8. If there is no evidence of heart failure at rest, large muscle groups rather than small muscle groups
what is the chance that insufficiency will de (e.g., arm ergometry) is selected to minimize the in
velop with exercise? creased hemodynamic demand and strain and the in
Comparable with the management of the patient with creased work of the heat1 associated with this type of
a history of angina with or without a history of my work. As for other types of cardiac conditions, exercis
ocardial infarction, body positions, activities, and res ing in hot and humid conditions shoud be avoided.
piratory maneuvers that are associated with increased The body position in which aerobic exercise is
hemodynamic strain are avoided. performed is important in patients with heart disease.
Medication that is needed to maximize treatment Positions of recumbency increase the volume of fluid
response is administered before treatment. Knowl shifted from the periphery to the central circulation.
edge of the type of medication, its administration This increases venous return and the work of the
route, and time to and duration of peak efficacy is es heart. Thus upright body positions are selected for
sential if treatment is to be maximally efficacious. these patients to minimize cardiac work during exer
These patients are potentially hemodynamically cise and during rest after exercise (Langou et aI.,
unstable; thus their hemodynamic responses before, 1977; Levine and Lown, 1952).
during, and after treatments, particularly exercise,
should be monitored and recorded. Monitoring in
Peripheral Vascular Disease
cludes hemodynamic monitoring (i.e., heart rate,
Patholphysiology and medical management
blood pressure, and rate prcssure product). Subjective
responses to treatment (e.g., rating of perceived exer Peripheral vascular disease results primarily from ather
tion) should also be recorded. Signs of dyspnea, chest osclerosis and occlusion of the peripheral arteries (e.g.,
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530 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
thoracic aorta, femoral artery, and popliteal artery) • Educate about atherosclerosis, self-management,
(Juergens, Spittell, and Fairbairn, 1980). Diabetes mel nutrition, weight control, smoking reduction and
litus, which can result in microangiopathy and auto cessation, risk factors, disease prevention, medica
nomic polyneuropathy, is another contributing factor to tions, life style, activities of daily living, and
peripheral vascular disease in the lower extremjties. avoiding static exercise, straining, and the Valsalva
Al1erial occlusion results in reduced blood flow to maneuver
the extremities and hence reduced segmental blood • Maximize arobic capacity and efficiency of oxy
pressure distal to the occlusion. In mild cases of arter gen transport
ial stenosis the patient may be asymptomatic because • Optimize the work of the heart
considerable stenosis has to occur before significant • Optimize physical endurance and exercise ca
reduction in peripheral blood flow. Furthermore, if pacity
atheroslerosis develops gradually, collateral circula • Optimize general muscle strength and thereby
tion may develop sufficiently to offset progressive peripheral oxygen extraction
vessel narrowing. Clinically, the patient presents with The goals of long-term management of the patient
complaints of limb pain on exercise, coldness in the with peripheral vascular disease secondary to dia
affected leg, and possibly numbness (Dean, 1987). betes mellitus must incorporate both the principles
The characteristic limb pain results from ischemia and for the managment of the patient with peripheral vas
is referred to as intermittent claudication. Mild to cular disease secondary to atherosclerosis and sec
moderately severe cases are managed conservatively. ondary to diabetes mellitus.
Pain at rest is suggestive of severe stenosis and signif Patient monitoring includes hemodynamic moni
icant reduction of blood flow to the limb. Signifi toring (i.e., heart rate, blood pressure, and rate pres
cantly reduced blood flow leads to ischemia color sure product). Subjective responses to treatment,
changes, skin breakdown, ulceration, and eventually particularly exercise, should also be recorded (e.g.,
gangrene. Bypass surgery is carried to revascularize a pain scale and Borg's rating of perceived exertion).
threatened limb or in severe cases where gangrene has These patients have an increased risk of angina.
developed, amputation of the limb is indicated. Angina is not an acceptable symptom under any cir
Intermittent claudication secondary to mild-to cumstance. Thus patients should be cleared by their
moderate arterial stenosis can benefit from aerobic physicians or cardiologists before undertaking a
exercise, which may stimulate the development of therapeutic exercise program. Diabetic patients are
collateral blood vessels around the stenosed vessel. potentially hemodynamically unstable; thus their he
This condition can severely restrict mobility, which modynamic responses before, during, and after
reduces function in addition to aerobic capacity and treatment, particularly exercise, should be moni
efficient oxygen transport overall. tored and recorded (i.e., heart rate, blood pressure,
Patients with pelipheral vascular disease from dif and rate pressure product should be taken) along
fuse systemic atherosclerosis can be expected to have with their subjective responses to exercise (e.g.,
stenosis of the coronary arteries even though they pain and perceived exertion). If there is any doubt at
may be asymptomatic. These patients are monitored any time about the hemodynamic stability of a pa
as stringently as cardiac patients. tient and her or his ability to tolerate treatment
safely, the patient shou. l d be referred to a general
Principles of physical therapy management practitioner for clearance before being treated or
The goals of long-term management of the patient continuation of treatment.
with peripheral vascular disease secondary to athero Medication that is needed to maximize treatment
sclerosis include the following: response is administered before treatment. Knowl
• Maximize the patient's quality of life, general edge of the type of medication, its administration
health, and well-being and hence physiological route, and time to and duration of peak efficacy is es
reserve capacity sential if treatment is to be maximally efficacious.
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29 Chronic Primary Cardiopulmonary Dysfunction 531
The primary interventions for maximizing car The body position in which aerobic exercise is per
diopulmonary function and oxygen transport in patients formed is important in patients with peripheral vascu
with pe[ipheral vascular di:;ease secondary to athero lar disease. Positions of recumbency eliminate the
sclerosis include some combination of education, aero vertical gravitational gradient. This gradient increases
bic exercise, strengthenjng exercises, relaxation, activ blood pressure significantly to the lower extremeites.
ity pacing, and energy conservation. An ergonomic Therefore the claudication threshold is lowered in re
assessment of both work and home environments may cumbent positions. Recumbent positions also increase
be indicated to minimize myocardial strain. venous return and the work of the heart. Thus upright
Education focuses on teaching the basic patho body positions are selected for these patients to maxi
physiology of atherosclerosis, its risk factors, and mize blood pressure in the lower extremities and to
prevention. Health promotion practices are advocated minimize cardiac work during exercise and during rest
(e.g., smoking reduction and cessation, nutrition, after exercise (Langou et aI., 1977).
weight control, hydration, quality rest, and sleep peri
ods). In addition, types of physical activity that im
Hypertension
pose undue myocardial strain, increase intrathoracic
pressure, and restict venous return and cardiac output,
Pathophysiology and medical management
such as heaving lifting, straining, or the Valsalva ma Hypertension or high blood pressure is a serious
neuver, are avoided. The patient is taught to monitor condition. Most patients experience no symptoms;
and practice vigilance in monitoring signs and symp thus adherence to medication regimens is often
toms of vascular insufficiency in the affected limb poor. Approximately 90% of hypertension is termed
and intermittent claudication. Any sign of skin red essential hypertension (i.e., no known etiology).
ness in the feet should be monitored closely. In the Hypertension predisposes a patient to stroke, my
diabetic patient, any threat of skin breakdown re ocardial infarction, hemorrhage, and infarction of
quires medical attention and discontinuation of exer other vital organs (Sokolow, McIlroy, and Cheitlin,
cise until medical clearance has been obtained. Pa 1990). Blood pressure tends to increase with age.
tients with peripheral artery disease are taught to take With the aging of the population, the incidence of
care of their feet particularly before and after exer hypertension is increasing. Increased blood pressure
cise. The feet and footwear should be kept clean. The results from increased peripheral vascular resis
inner surfaces of shoes and socks should be smooth. tance; therefore medications are prescribed that re
During peak exercise tests, patients with periph duce myocardial afterload and peripheral vascular
eral vascular disease secondary to atherosclerosis resistance (Goldberger, 1990).
have an increased risk of angina or ST-segment Patients with existing cardiovascular disease (i.e.,
changes. Such tests therefore should be performed in hypertension) are at risk for other manifestations. In
a peripheral vascular laboratory or cardiac stress test addition, this population tends to be older and older
ing laboratory under the supervision of a peripheral populations are known to have a higher prevalence of
vascular specialist or cardiologist. The parameters of cardiac dysrhythmias. Thus knowledge of cardiac sta
the exercise prescription are based on a peak exercise tus, including ECG history, should be obtained.
test. Walking is the activity/exercise of choice be
cause this activity is most severely limited by inter
PrinCiples of physical therapy management
mittent claudication, which has significant implica Physical therapy contributes to increased metabolical
tions for function. Intensity of the training stimulus is demands and therefore imposes a hemodynamic load
based on pain rating in conjunction wi th hemody resulting in increased heart rate and blood pressure.
namic and other subjective responses. The patient The assessment should document the history of hy
walks at a comfortable, even cadence within her or pertension, its medical management, and the patient's
his pain tolerance (objectively defined on the pain response. Regardless of the condition being treated,
scale) so that limping and gait deviation is avoided. the hypertensive patient's blood pressure must be
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532 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chl"Onic Cardiopulmonary Conditions
monitored and treatment modified accordingly. How sure product). Subjective responses to treatment, par
ever, blood pressure medications are known to atten ticularly exercise, should also be recorded. Signs of
uate hemodynamic responses to exercise (Chapter dyspnea, headache, lighheadedness, dizziness, disori
43) ; thus the limitations of blood pressure measure entation, discoordi nation, cyanosis, coughing, and
ment must be considered. chest sound changes (i.e., a gallop) need to be moni
A program of aerobic exercise can effectively re tored. Blood pressure responses that fail to increase
duce high blood pressure in some patients (Blair, with increasing work load and power output may be
1988; Sannerstedt,
Painter, Pate, Smith, and Taylor, indicative of congestive healt failure.
1987). The parameters of the exercise prescription Treatments will be safer and more precisely pre
needed to control hypertension include an aerobic scribed with contiuous ECG monitoring. Without ECG
type of exercise that is rhythmic and involves large monitoring, treatments need to be conservative. If there
muscle groups, an intensity of 60% to 75% of the pa is any doubt about the hemodynamic stability of a pa
tient's age predicted maximal heart rate, 60 to 90 min tient and her or his ability to tolerate treatment safely,
utes in duration, performed 5 to 7 times weekly, for 3 the patient should be referred to a general practitioner
months to achieve an optimal effect. The exercise in or cardiologist for clearance before being treated.
tensity should be equivalent to a perceived exertion Medication that is needed to maximize treatment
rating of 3 to 5 on the Borg scale (the patient is able to response is administered before treatment (i.e., hyper
speak while exercising without gasping) provided that tension medications). Knowledge of the type of med
blood pressure has not increased excessively. Only ication, its administration route, and time to and dura
modest exercise intensities are prescribed if the pa tion of peak efficacy is essential if treatment is to be
tient has extremely high resting blood pressure to en maximally efficacious.
sure that the blood pressure does not rise excessively The primary interventions in the long-term man
and is not maintained at a high pressure for a pro agement of hypertension include education, aerobic
longed period. If the patient's hypertension responds exercise, general body strengthening, range of motion,
to the exercise regimen, exercise needs to be included body mechanics, relaxation, stress management, pac
into the patient's life style in order for the effects to be ing, and energy conservation. The patient is instructed
maintained. In addition to exercise, many patients lose in self-monitoring blood pressure, recording her or his
weight, adopt healthier life-style habits, and learn blood pressure and those factors that associated with
stress management and coping skills concurrently. both high and low pressures, and blood pressure
The goals of long-term management of the patient changes after having had medication. Such monitoring
with hypertension include the following: enables the patient to self-manage his or her hyperten
•
Maximize the patient's quality of life, general sion and thereby reduces the need for medication, if
health, and well-being and hence physiological re not, eliminate it entirely. Patients, however, should
serve capacity only alter their medications with their physicians' ap
•
Educate about hypertension, self-management, nu proval. Physical therapists work closely with both hy
trition, weight control, smoking reduction and ces pertensive patients and physicians.
sation, risk factors, life-style factors, disease pre Systemic blood pressure responses to dynamic ex
vention, medications and their applications and ercise are greater for upper-extremity than for lower
side effects extremity work (Dean and Ross, 1992). Thus exer
•
Maximize aerobic capacity and efficiency of oxy cise prescription includes aerobic exercise of the
gen transport large muscle groups to avoid small muscle group
•
Optimize physical endurance and exercise capacity work and increasing peripheral vascular resistance
•
Optimize general muscle strength and thereby pe and hence hemodynamic work, and the increased ex
ripheral oxygen extraction ertion, strain, and work of the heart experienced with
Patient monitoring includes hemodynamic moni upper-extremity work. Exercise is also performed in
toring (i.e., heart rate, blood pressure, and rate pres erect and upright rather than recumbent positions to
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29 Chronic Primary Cardiopulmonary Dysfunction 533
minimize the increased work of the heart secondary can be tolerated over the short term. However, these
to central fluid shifts when the patient is Lying in re factors may result in a critical situation for the dia
cumbent positions. betic patient.
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534 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
Hypoglycemia or low blood sugar is one of the lant in monitoring signs and symptoms of vascular in
most common complications of diabetes mellitus. sufficiency in the affected limb. Any sign of skin red
This condition results from excess administration of ness in the feet should be monitored closely. In dia
insulin or oral hypoglycemic agent, insufficient food betic patients, any threat of skin breakdown requires
in relation to insulin dose, or an abnormal increase in medical attention and discontinuation of exercise until
physical activity or exercise. Hyperglycemia is com medical clearance has been obtained. Healing is con
mon in obese patients with adult-onset diabetes. High siderably delayed in the diabetic foot. Without appro
insulin levels are associated with a higher risk of priate attention, infection and potential necrosis can
coronary artery disease. Myocardial infarction and ensue. Patients with peripheral neuropathy are taught
stroke are common causes of death. Another compli to monitor their footwear and socks diligently, to en
cation is cardiac hypertrophy secondary to hyperten sure the inner surfaces are clean and smooth before
sion and cardiomyopathy, which predisposes the pa each exercise session, and to check for areas of red
tient to congesti ve heart failure. The incidence of ness or abrasion of their feet after exercise.
peripheral vascular disease is also increased in dia Medication that is needed to maximize treatment
betic patients. response is administered before treatment (e.g., in
The goals of the long-term management of dia sulin or oral hypoglycemic agents). Knowledge of the
betes mellitus include the following: type of medication, its administration route, and time
• Maximize the patient's quality of life, general to and duration of peak efficacy is essential if treat
health and well-being, and hence physiological re ment is to be maximally efficacious.
serve capacity The primary interventions in the long-term man
•
Educate about diabetes mellitus, self-management, agement of diabetes mellitus include education,
nutrition, weight control, blood sugar regulation maintainance of a log of diet and insulin regimens,
and its managment (i.e., the balance between nu activity and exercise, aerobic exercise, strengthening
trition, diet, exercise, stress and insulin require exercises, relaxation, stress management, activity
ments), medications, smoking reduction or cessa pacing, and energy conservation.
tion, relaxation, stress management, foot care, Generally, there are no contraindications to patients
hygiene, and infection control with diabetes mellitus being physically active and par
•
Maximize aerobic capacity and efficiency of oxy ticipating in an exercise program. Daily exercise is ad
gen transport vocated for insulin-dependent and non-insulin-depen
•
Optimize physical endurance and exercise capacity dent diabetic patients to optimize glucose control. The
•
Optimize general muscle strength and thereby pe exercise prescription parameters are set at 40% to 85%
ripheral oxygen extraction of peak functional work capacity (American College
Patient monitoring includes signs and symptoms of of Sports Medicine, 1991). If the patient is exercising
hypoglycemia (e.g., lightheadedness, weakness, fa daily, the exercise parameters are set at the lower end
tigue, disorientation, and glucose tolerance test) or hy of this range. If the exercise sessions are less frequent
perglycemia (e.g., glucose tolerance test). Hemody (e.g., in the case of a non-insulin-dependent diabetic
namic responses (i.e., heart rate, blood pressure, and patient whose blood glucose is well maintained and
rate pressure product) provide an index of the inten whose weight is acceptable) the exercise intensity is
sity of an exercise stimulus, however, these responses set at the higher end of this range.
may be attentuated in the diabetic patient because of The risk of hypoglycemia can be reduced by observ
the autonomic neuropathy; both parasympathetic and ing the following precautions: frequently monitor blood
sympathetic neuropathies. glucose, decrease the insulin dose (in consulting with
Subjective responses to exercise, including the rat the physician) or increase carbohydrate intake before
ing of perceived exertion, may be more valid indica exercise, avoid injecting insulin into areas that are ac
tors of exercise intensity than hemodynamic responses tive during exercise, avoid exercise during peak insulin
in the diabetic patient. The patient is taught to be vigi activity, consume carbohydrates before, during, and
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29 Chronic Primary un'l'u"mu",,,, J Dysfunction 535
SUMMARY
References
This reviews the medical
American College of Sports Medicine, (1991). ACSM's guidelines
management, and physical management of
for exercise testing and prescription (4th ed,), Philadelphia:
primary, cardiopulmonary IJU'UV"V" Given
Williams & Wilkins,
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Copyrighted Material
Chronic Secondary Cardiopulmonary
Dysfunction
Elizabeth Dean
Donna Frownfelter
INTRODUCTION
injury, and the late sequelae of poliomyelitis. The
The purpose of this chapter is to review the patho musculoskeletal conditions that are presented include
physiology, medical management, and physical ther kyphoscoliosis and osteoporosis. The collagen vascu
apy management of chronic, secondary cardiopul lar/connective tissue conditions that are presented in
monary pathology. Specif ically, this chapter clude systemic lupus erythematosus, scleroderma,
addresses chronic cardiopulmonary dysfunction sec ankylosing spondylitis, and rheumatoid arthritis. Fi
ondary to neuromuscular, musculoskeletal, collagen nally, management of the patient with chronic renal
vascular/connective tissue, and renal dysfunction. insufficiency is presented. The principle.<> of manage
The neuromuscular conditions that are presented in ment are presented rather than treatment prescrip
clude muscular dystrophy, hemiplegia, Parkinson's tions, which cannot be given without consideration of
disease, multiple sclerosis, cerebral palsy, spinal cord a specific patient. (For specific examples of patient
537
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538 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
treatment prescriptions refer to the companion text abnormal ventricular wall motion. Fatty and fibrous
Clinical case studies in cardiopulmonary physical tissue infiltrate the myocardium and conduction sys
therapy.) In this context the goals of long-term man tem and electrical conduction is slowed. Thus sub
agement of each condition are presented, followed by clinical cardiac involvement is prevalent in patients
the essential monitoring required and the primary in with muscular dystrophy and may explain sudden
terventions for maximizing cardiopulmonary function death in this patient population.
and oxygen transport. The selection of interventions Chronic respiratory muscle weakness is character
for any given patient is based on the physiological hi istic of muscular dystrophy and other neuromuscular
erarchy. The most physiological interventions are ex disorders. Because the cardiopulmonary system is sel
ploited followed by less physiological interventions dom stressed due to musculoskeletal dysfunction in
and those whose efficacy is less well documented these patients, respiratory muscle weakness is seldom
(Chapter 16). detected. Such weakness is significant, however, in
that it contributes to several other serious problems,
including thoracic mechanical abnormalities, diffuse
NEUROMUSCULAR CONDITIONS
microatelectasis, reduced lung compliance, a weak
Muscular Dystrophy
cough with impaired mucociliary transport and secre
Pathophysiology and medical management
tion accumulation, ventilation and perfusion imbal
Degenerative neurological and muscular diseases, in ance, and noctural hypoxemia (Smith, Calverley, Ed
cluding Duchenne's muscular dystrophy, lead to res wards, Evans, and Campbell, 1987; Smith, Edwards,
piratory muscle weakness and alveolar hypoventila and Calverley, 1989). Progressive respiratory muscle
tion (Black and Hyatt, 1971; Braun, Arora, and weakness increases the risk of respiratory muscle fa
Rochester, 1983; Inkley, Alderberg, and Vignos, tigue and failure (Macklem and Roussos, 1977).
1974). Vital capacity, forced expiratory volume, air The severity of disease is not consistently corre
flow rates, and maximum inspiratory and expiratory lated with compromised pulmonary function; thus
pressures are reduced. These patients are at risk for cardiopulmonary function must be assessed individu
the development of atelectasis, impaired mucociliary ally in each patient (Hapke, Meek, and Jacobs, 1972).
transport, and pneumonia. In addition, long-term gen Patients with mild-to-moderate involvement of pe
eralized muscular weakness, particularly of the tho ripheral muscles may exhibit disproportionate respi
racic cavity and abdomen, as well as restricted mobil ratory compromise (Kilbull1, Eagan, Sieker, and Hey
ity and confinement to a wheelchair, predispose the man, 1959). This may be explained by differential
patient to thoracic deformities (e.g., scoliosis and changes in the degree of involvement of the di
dropping of the ribs, and further muscle disuse). Pa aphragm and the abdominal and intercostal muscles
tients with Duchenne' s muscular dystrophy are sus (Nakano, Bass, Tyler, and Carmel, 1976). Over time,
ceptible to dysphagia and upper airway obstruction musculoskeletal changes of the chest wall lead to
secondary to gag reflex depression and hypotonia of spinal deformity and stiffness with loss of its elastic
the pharyngeal structures (Murray and Nadel, 1988a). recoil. Chronic alveolar hypoventilation leads to res
These factors further compromise or threaten car piratory insufficiency and the need for ventilatory as
diopulmonary function and oxygen transport. sistance. With progressive respiratory insufficiency,
Cardiac dysfunction has also been reported in pro noctural hypoventilation with hypercapnia and hy
gressive muscular dystrophy (Moorman et aI., 1985; poxemia develop (Bach, O'Brien, Krotenberg, and
Perioff, de Leon, and O'Doherty, 1966). Although Alba, 1987). Nocturnal respiratory support should be
the majority of patients have no clinical evidence of considered early to postpone the need for intubation
cardiac dysfunction, a high proportion have abnormal and mechanical ventilation, which is associated with
E CGs at rest or during exercise and a b n o r m a l a poor prognostic outcome in patients who have
echocardiography and radionuclide ventriculography chronically reduced vital capacities and weak cough.
showing reduced left ventricular ejection fraction and Clinically, patients with muscular dystrophy pre
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30 Chronic Secondary Cardiopulmonary Dysfunction 539
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540 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
diture in these settings. Such an assessment includes impaired, leading to secretion accumulation, postural
review of aids and devices (e.g., wheelchair type, drainage may need to be instituted, coupled with deep
weight, and size and noninvasive mechanical ventila breathing and coughing maneuvers.
tion). Aids and devices are selected to minimize en Although the primary factor contributing to respi
ergy demand such that energy is conserved for other ratory compromise is respiratory muscle weakness,
activities and undue fatigue is reduced. the capacity of the respiratory muscles to respond to
The use of supplemental oxygen depends on the resistive loading is limited. However, ventilatory
severity of the disease. Some patients have no need muscle training may have some role in selected pa
for supplemental oxygen, some need it only during tients, particularly children (Adams and Chandler,
exercise, and some patients require continuous oxy 1974; Pardy and Leith, 1984). Improved respiratory
gen with proportionately more delivered during activ muscle endurance and strength may have a general
ity and exercise compared with rest. ized effect on functional capacity (Reid and Warren,
Education is a principal focus of the long-term 1984). Patients with signs of ventilatory muscle fa
management of the patient with muscular dystrophy. tigue, as opposed to weakness, benefit from ventila
Education includes the reinforcement of preventative tory support at night. Rest of the respiratory muscles
health practices (e.g., infection control, cold and flu at night optimizes their function during the daytime.
prevention, flu shots, aerobic exercise, strengthening Methods of facilitating effecti ve coughing in pa
exercises, nutrition, weight contrOl, hydration, pacing tients with neuromuscular diseases are extremely im
of activities, and energy conservation). Weight control portant because they constitute life-preserving mea
is an important goal in patients with chronic neuro sures. Supported and unsupported coughing methods
muscular diseases because they have the least capacity are described in detail in Chapters 20 and 21. Patients
to compensate for the cardiopulmonary sequelae of on noninvasive ventilatory support who are unable to
obesity (Alexander, 1985). Obstructive sleep apnea is generate adequate peak cough expiratory flow rates
related to hypotonia of the upper airway musculature can benefit from manual assisted coughing and me
and obesity. Thus activity and sleep patterns need to chanical insufflation-exsufflation, thereby minimiz
be assessed to ensure sleep is maximally restorative ing the need for endotracheal suctioning (Bach, 1993;
and not contributing to the patient's symptoms. Barrach, Beck, Bickerman, and Seanor, 1952). Tra
Mobilization is an essential component of the long cheostomy is delayed as long as possible. Signifi
term management of the patient with muscular dystro cantly reduced maximal insufflation capacity, how
phy to optimize the efficiency of oxygen transport ever, is an indication for tracheostomy.
overall and minimize the sequelae of restricted mobil Whenever possible, deep breathing and coughing
ity, including circulatory stasis. Maximizing ventila are coupled with chest wall movement to facilitate
tion with mobilization is limited if the patient has se maximal inflation of the lungs before coughing by in
vere generalized muscular weakness and increased creasing pulmonary compliance (Ferris and Pollard,
fatigue. Functional activities provide the basis for the 1960) and maximal exhalation of the lungs during
mobilization prescription. Although heavy resistive coughing. Body positions are varied and changed fre
strengthening exercise has been advocated for these quently to simulate shifts in alveolar volume and ven
patients (Vignos and Watkins, 1966), a conservative tilation and perfusion that occur with normal move
approach, including an exercise program based on ment and body position changes. Glossopharyngeal
functional goals and energy conservation, is more jus breathing is a nonmechanical method of assisting
tifiable physiologically. Chest wall mObility exercises ventilation. The patient is taught to use the tongue
include all planes of movement combined with a rota and pharyngeal muscles to swallow boluses of air
tional component. Body positioning to optimize lung past the vocal cords and into the trachea (Bach, Alba,
volumes and airflow rates is a priority. Breathing con Bodofsky, Curran, and Schultheiss, ) 987). The effi
trol and coughing maneuvers are coupled with body ciency of training is monitored with spirometry to en
movement and positioning. If mucociliary transport is sure the patient is able to achieve acceptable vital ca
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30 Chronic Secondary Cardiopulmonary Dysfunction 541
pacities. Some patients are able to support their venti can affect cardiopulmonary function. Such infarc
lation, ventilator-free, for several hours in a day. tions, however, are I ikely to be lethal. More com
One intervention that is prolonging the life of pa monly, after a stroke, chest wall movement and elec
tients with muscular dystrophy, as well as of patients trical activity on the ipsilateral side are reduced
with other progressive neuromuscular diseases, is the (DeTroyer, DeBeyl, and Thirion, 1981; Fluck,
use of mechanical ventilatory support (Bach, 1992; 1966). Facial and pharyngeal weakness contributes
Curran, 1981). Home mechariical ventilation provides to an inability to control oral secretions, swallow ef
a noninvasive method of providing positive airway fectively, and protect the upper airway. Altered res
pressure through an oral or nasal mask. This provides piratory mechanics and efficiency reflect impaired
considerable advantage over invasive, full body or chest wall movement, asymmetry, and the degree of
tracheostomy. ventilatory support. Used in conjunc muscle paresis and spasm.
tion with an insufftation-exsufflation device, pul Patients with hemiplegia have associated problems
monary complications can be minimized and life ex that contribute to cardiopulmonary dysfunction.
pectancy increased. Other forms of noninvasive These patients tend to be older, hypertensive, and
mechanical ventilation include intermittent abdomi have a high incidence of cardiac dysfunction. Muscle
nal pressure ventilation, rocking bed, negative pres disuse and restricted mobility secondary to hemiple
sure tank ventilator, and chest shell ventilator. The gia lead to reduced cardiopulmonary conditioning
type of ventilation is determined individually based and inefficient oxygen transport. Spasticity increases
on the indications for ventilation and the patient's metabolical and oxygen demand. Hemiparesis results
status. The use of ventilatory aids as a component of in gait deviations, which reduce movement efficiency
a comprehensive rehabilitation program maintains and movement economy. Reduced movement econ
pulmonary compliance and cough efficacy. Introduc omy results in an increased energy cost associated
tion of these devices early will facilitate increased use with ambulation, which may reduce exercise toler
as the respiratory muscles progressively weaken. ance because of fatigue (Dean and Ross, 1993). In
Patients with generalized neuromuscular weakness addition, ambulating with a walking aid is associated
require prophylactic management given their high with a significantly increased energy cost compared
risk of developing life-threatening respiratory infec with normal walking. This increased energy cost re
tions and complications. Prophylaxis should include duces the patient's exercise tolerance further and in
flu shots, avoiding polluted, smoky environments, creases fatigue.
smoking reduction and cessation, controlling the
types of food eaten and chewing well to avoid chok
Principles of physical therapy management
ing, and regular deep breathing, frequent movement, The goals of long-term management for the patient
and change in body positions (even just shifting and with hemiplegia include the following:
taking some deeper breaths while seated in a wheel • Maximize the patient's quality of life, general
chair) to promote mucociliary transport. An optimal health, and well-being and hence physiological
time to take deep breaths and to cough is during reserve capacity
transfers, which usually are physically exerting and • Educate about cardiopulmonary manifestations of
stimulate hyperpnea. hemiplegia, self-management, medications, smok
ing reduction and cessation, nutrition, weight con
trol, and the role of a rehabilitation program
Hemiplegia
• Optimize alveolar ventilation
Pathophysiology and medical management • Optimize lung volumes and capacities and flow
Hemiplegia or stroke affects cardiopulmonary func rates
tion either directly or indirectly (Fugl-Meyer and • Optimize ventilation and perfusion matching
Grimby, 1984; Griggs and Donohoe, 1982). A cere and gas exchange
bral infarct involving the vital centers of the brain • Reduce the work of breathing
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542 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
• Reduce the work of the heart sleep apnea). Thus activity and sleep patterns need to
• Protect the airways from aspiration be assessed to ensure sleep is maximally restorative
• Facilitate mucociliary transport and not contributing to the patient's symptoms.
• Optimize secretion clearance Aerobic excrcise is an essential component of the
• Maximize aerobic capacity and efficiency of long-term management of the patient with hemiplegia
oxygen transport to optimize the efficiency of oxygen transport overall.
• Optimize physical endurance and exercise Maximizing ventilation with mobilization is limited if
capacity the patient has severe generalized muscular weakness
• Optimize general muscle strength and thereby and increased fatigue. Although aggressive mobiliza
peripheral oxygen extraction tion can be supported in these patients (Malouin,
Patient monitoring includes dyspnea, respiratory Potvin, Prevost, Richards, and Wood-Dauphinee,
distress, breathing pattern (depth, symmetry, and fre 1992), appropriate selection of patients for such a reg
quency), arterial saturation, cyanosis (delayed sign of imen, judicious exercise prescription, and monitoring
desaturation), heart rate, blood pressure, and rate pres must be instituted to ensure the treatment is optimally
sure product. Patients with cardiac dysfunction require therapeutic and poses no risk to a patient in this high
clearance from a cardiologist before participating in a risk group. Chest wall exercises include movement in
rehabilitation program and may require ECG monitor all planes combined with rotation. Body positioning to
ing, particularly during exercise. Subjectively, per optimize lung volumes and aitflow rates is a priority.
ceived exertion is rated using the Borg scale. Breathing control and coughing maneuvers are essen
Medication that is needed to maximize treatment tial and should be coupled with body movement and
response is administered before treatment (e.g., anti positioning. Exercise is conducted in the upright posi
hypertensive and cardiac medications). Knowledge of tions to minimize the work of the heart and of breath
the type of medication, its administration route, and ing during physical exertion. Recumbent positions re
time to and duration of peak efficacy is essential if duce lung volumes and expiratory flow rates, impair
treatment is to be maximally efficacious. respiratory mechanics, increase closing volumes, in
The primary interventions for maximizing car crease thoracic blood volume, and increase compres
diopulmonary function and oxygen transport in pa sive forces on both the lungs and the heart (Dean and
tients with hemiplegia include some combination of Ross, 1992; Ross and Dean, 1992). Thus significant
education, aerobic exercise, strengthening exercises, periods and intensities of aerobic exercise should be
spasticity control, postural correction exercises, gait petformed standing or sitting. Lower-extremity work
reeducation, chest wall mobility exercises, range of is preferable to upper-extremity work in that the latter
motion exercises, body positioning, breathing control is associated with increased hemodynamic stress.
and coughing maneuvers, airway clearance interven Rhythmic exercise of large muscle groups is prefer
tions, activity pacing, and energy conservation. An er able to static exercise and exercise of small muscle
gonomic assessment of the patient's work and home groups, such as the arms, in that it produces smaller
environments may be indicated to minimize oxygen hemodynamic effects.
demand and energy expenditure in these settings. Ambulation or wheelchair locomotion should be
Education is a principal focus of the long-term as efficient as possible so that the metabolical de
management of the patient with hemiplegia. Educa mand of these functional activities is reduced. Per
tion includes the reinforcement of preventative health forming these activities inefficiently on a frequent
practices (e.g., infection control, smoking reduction basis contributes to an excessive oxygen demand.
and cessation, cold and flu prevention, flu shots, aero The patient expends considerable energy in perform
bic exercise, strengthening exercises, gait reeducation, ing these activities uneconomically, which impairs
nutrition, weight control, hydration, pacing of activi the patient's tolerance and contributes to excessive
ties, and energy conservation). Hemiplegia is often as fatigue. Conserving energy by performing these ac
sociated with sleep disturbances (e.g., obstructive tivities more economically from an energetic per
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30 Chronic Secondary Cardiopulmonary Dysfunction 543
spective will more energy to "PIc-fArm more of which has been associated with the disease. The de
these or other activities. gree to which these cardiopulmonary manifestations
neuromuscular weakness of the disease are offset with
their used to treat rest tremor and reverse
infec been reported.
Prophylaxis should include The upper extremities are rigid and held
polluted, smoky abducted from the chest wall during locomotion. The
smoking reduction and cessation, the rigidity and dyskinesia associated with Parkinson's
types of food eaten and chewing well to avoid chok disease leads to restricted movement and body
ing, and deep breathing, movement, tioning. The becomes deconditioned from dis
and positions (even just and use. The immobile chest, coupled with reduced
breaths while seated in a wheel body position contributes to
nrr,rYI.c>'p mucociliary transport. An monary
breaths and to
Principles nmrSIt:,al therapy management
are
The goals of management for the
with Parkinson's disease include the following:
• Maximize the quality of life,
Parkinson's Disease
health, and and hence physiological
Pathophysiology and medical management
reserve
Parkinson's disease i s associated w i t h reduced • Educate about cardiopulmonary manifestations
dopamine in the basal resulting in the loss of of Parkinson's d self-
normal inhibitory and neuronal smoking reduction a n d
input in the execution of smooth coordinated move weight
ment et 199 The clinical manifesta infection
tions of the disease include stooped posture, stiffness program
and slowed fixed masklike and • Optimize alveolar ventilation
tremor of the limbs. Patients with Parkinson's disease • Optimize volumes and capacities
and inflexible. Movement initi • Optimize ventilation and perfusion
reduced movement efficiency, and hence re • Maximize aerobic and efficiency of
duced movement economy. oxygen
Although chest wall rigidity and respiratory mus • Optimize endurance and exercise
cle weakness are associated with a restrictive capacity
of lung disease in the Parkinsonian patient (Mehta, • Optimize general muscle strength and thereby
Wright, and 1978), obstructive type of peripheral oxygen extraction
tory has been reported (e.g., reduced Patient monitoring includes respiratory
mid-tidal flow rates, increase airway resistance, im distress, breathing (depth and frequency),
paired distribution of ventilation, and an increase in arterial saturation, heart rate, blood pressure, and
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544 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
Multiple Sclerosis
sessed using a modified version of the Borg scale
Pathophysiology and medical management
of perceived exertion.
Medication that is needed to maximize treatment Multiple sclerosis is a demyelinating disease of the
response is administered before treatment (e.g., L central nervous system. The focal or patchy destruc
dopa). Knowledge of the type of medication, its ad tion of myelin sheaths is accompanied by an inflam
ministration route, and time to and duration of peak matory response (McFarlin and McFarland, 1982).
efficacy is essential if treatment is to be maximally The course of the disease consists of a variable num
efficacious. In addition, patients with Parkinson's ber of exacerbations and remissions over the years
may be on a beta-blocker to suppress action tremor. from early adulthood. Exacerbations are also vari
Because such medication reduces the heart rate and able with respect to severity. The neurological
blood pressure, these patients are prone to orthosta deficits include visual disturbance, paresis of one or
tic intolerance. In addition, heart rate and blood more limbs, spasticity, discoordination, ataxia,
pressure responses to treatment and exercises will dysarthria, weak, ineffective cough, reduced percep
be less valid. tion of vibration and position sense, bowel and blad
The primary interventions for maximizing car der dysfunction, and sexual dysfunction (Wilson,
diopulmonary function and oxygen transport in pa Braunwald, Isselbacher, Martin, Fauci, and Root,
tients with Parkinson's disease include some combi 1991). Breathing disturbances, including diaphrag
nation of education, aerobic exercise, strengthening matic paresis, may occur (Cooper, Trend, and Wiles,
exercises, postural correction exercises, gait reeduca 1985). Autonomic disturbance in the form of im
tion, chest wall mobility exercises, range of motion paired cardiovascular reflex function at rest and at
exercises, body positioning, breathing control and tenuated heart rate and blood pressure responses dur
coughing maneuvers, activity pacing, and energy ing exercise are relatively common in patients with
conservation. An ergonomic assessment of the pa mUltiple sclerosis (Neubauer and Gundersen, 1978;
tient's work and home environments may be indi Pentland and Ewing, 1987; Senaratne, Carroll, War
cated to minimize oxygen demand and energy expen ren,and Kappagoda, 1984).
diture in these settings.
Principles of physical therapy management
Education is a principal focus of the long-term
management of the patient with Parkinson's disease. The goals of long-term management for the patient
Education includes the reinforcement of preventative with mUltiple sclerosis include the following:
health practices (e.g., infection control, airway pro • Maximize the patient's quality of life, general
tection, smoking reduction or cessation, cold and flu health, and well-being and hence physiological
prevention, flu shots, aerobic exercise, strengthening reserve capacity
exercise, nutrition, weight control, hydration, pacing • Educate about cardiopulmonary manifestations
of activities, and energy conservation). of mUltiple sclerosis, self-management, medica
Aerobic exercise is an essential component of the tions, smoking reduction and cessation, nutri
long-term management of the patient with Parkinson's tion, weight control, infection control, and the
disease to optimize the efficiency of oxygen transport role of a rehabilitation program
overall, including maximizing alveolar ventilation and • Optimize alveolar ventilation
mobilizing secretions, as weJl as its musculoskeletal • Optimize lung volumes and capacities and flow
benefits. Maximizing ventilation with mobilization is rates
limited by the degree of hypertonicity and rigidity. • Optimize ventilation and perfusion matching
Chest wall exercises include all planes of movement and gas exchange
with a rotational component. Breathing control and • Reduce the work of breathing
coughing maneuvers are essential and should be cou • Reduce the work of the heart
pled with body movement and positioning. • Protect the airways from aspiration
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30 Chronic Secondary Cardiopulmonary Dysfunction 545
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546 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
dinated with chest wall movement to facilitate maxi ipate actively in a long-term rehabilitation pro
mal inflation of the lungs before coughing and maxi gram. Patients with cerebral palsy who are able to
mal exhalation of the lungs during coughing. Body ambulate do so at exceptional energy expenditure
positions are varied and changed frequently to simu both with and without walking aids (Campbell and
late as much as possible shifts in alveolar volume and Ball, 1978; Mossberg, Linton, and Friske, 1990).
ventilation and perfusion that occur with normal Central neurological deficits, generalized hyper
movement and body position changes (Ray et aI., tonicity, and musculoskeletal deformity contribute
1974). In addition, body positioning is used to maxi to increased metabolical demand for oxygen and
mize the patient's coughing efforts. oxygen transport.
Patients with generalized neuromuscular weakness
require prophylactic management given their high
Principles of phYSical therapy management
risk of developing life-threatening respiratory infec The goals of long-term management for the patient
tions and complications. Prophylaxis should include with cerebral palsy include the following:
flu shots, avoiding polluted, smoky environments, • Maximize the patient's quality of life, general
smoking reduction and cessation, controlling the health, and well-being and hence physiological
types of food eaten and chewing well to avoid chok reserve capacity
ing, and regular deep breathing, frequent movement, • Educate patient and/or family about cardiopul
and change in body positions (even just shifting and monary manifestations of cerebral palsy, self
taking some deeper breaths while seated in a wheel management, medications, nutrition, weight
chair) to promote mucociliary transport. An optimal control, airway protection, infection control, and
time to take deep breaths and to cough is during the role of a rehabilitation program
transfers, which usually are physically exerting and • Optimize alveolar ventilation
stimulate hyperpnea. • Optimize lung volumes and capacities and flow
rates
• Optimize ventilation and perfusion matching
Cerebral Palsy
and gas exchange
Pathophysiology and medical management
• Reduce the work of breathing
Cerebral palsy results from insult to the central ner • Reduce the work of the heart
vous system usually before birth (e.g., substance • Protect the airways from aspiration
abuse and underoxygenation perinatally) (Wilson et • Facilitate mucociliary transport
aI., 1991). The clinical presentation includes spas • Optimize secretion clearance
ticity and residual deformity from severe muscle • Maximize aerobic capacity and efficiency of
imbalance, hyperreflexia, and mental retardation. oxygen transport
Although there are varying degrees of cerebral • Optimize physical endurance and exercise ca
palsy severity, patients most frequently seen by pacity
physical therapy have significant functional deficits • Optimize general muscle strength and thereby
and require long-term care. The loss of motor con peripheral oxygen extraction
trol and hypertonicity of peripheral muscles often Maximizing aerobic capacity and efficiency of
restrict the mobility of patients such that they are oxygen transport and optimizing general muscle
wheelchair dependent. Loss of motor function lim strength pertain to the patient with cerebral palsy that
its p hysical activity and the exercise stimulus is mild in severity. Unfortunately, many patients seen
needed to maintain an aerobic stimulus and optimal by physical therapists have poorly controlled spastic
aerobic capacity. Often coupled with motor deficits ity and extreme cognitive deficits, which preclude
are cognitive deficits and mental retardation. These full participation in aerobic and strengthening exer
afflictions limit the degree to which the patient can cise programs. These patients are at risk for the se
follow instructions, perform treatments, and partic quelae of restricted mobility and recumbency.
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30 Chronic Secondary Cardiopulmonary Dysfunction 547
Patient monitoring includes dyspnea, respiratory patients often have poor swallowing and saliva con
distress, breathing pattern (depth and frequency), ar trol and thus are prone to aspiration and microat
terial saturation, cyanosis (delayed sign of desatura electasis, particularly when recumbent at night. In
tion), heart rate, blood pressure, and rate pressure ability to reposition themselves at night further
product. Unless mildly affected and not mentally in increases the risk of aspiration and its sequelae.
capacitated, patients with cerebral palsy are less able Mobilization is an essential component of the
to provide subjective ratings of treatment response; long-term management of the patient with cerebral
thus the physical therapist relies particularly on clini palsy to stimulate aerobic metabolism and optimize
cal judgment in conjunction with the patient's objec the efficiency of oxygen transport overall, including
tive responses to treatment. maximizing alveolar ventilation and mobilizing and
Medication that is needed to maximize treatment removing secretions (Wolff, Dolovich, and Obmin
response is administered before treatment (e.g., anti ski, 1977). Maximizing ventilation with mobilization
spasticity medications). Knowledge of the type of is limited if the patient has generalized spasticity.
medication, its administration route, and time to and Furthermore, mobilization stimuli are selected specif
duration of peak efficacy is essential if treatment is to ically to minimize eliciting further muscle spasm.
be maximally efficacious. Prescriptive hydrotherapy and equinotherapy (horse
The primary interventions for maximizing car back riding) can provide effective stimulation to the
diopulmonary function and oxygen transport in pa cardiopulmonary system in the multiply handicapped
tients with cerebral palsy include some combination individual and minimize the effects of spasticity.
of education, mobilization and coordinated activity With training, coordination of ambulatory patients
(aerobic stimulation), strengthening e xercises can be improved and aerobic energy expenditure re
(strength is often difficult to assess and treat because duced (Dresen, de Groot, and Bouman, 1985). In ad
of overwhelming spasticity), chest wall mobility ex dition, energy is conserved for performing more ac
ercises, range of motion exercises, body positioning, tivity. Chest wall exercises includes all planes of
breathing control and coughing maneuvers, and air movement with rotation. Body positioning to opti
way clearance interventions. mize lung volumes and airflow rates is a priority.
Education is a principal focus of the long-term Breathing control and coughing maneuvers are essen
management of the patient with cerebral palsy. tial and should be coupled with body movement and
Whenever possible, education is directed at the pa positioning. If mucociliary transport is impaired lead
tient, but it more likely is directed at the parents and ing to secretion retention, postural drainage and man
care providers. Education includes the reinforce ual techniques may need to be instituted with appro
ment of preventative health practices (e.g., infection priate monitoring to ensure they do not have a
control, cold and flu prevention, flu shots, mobiliza detrimental effect (Kirilloff, Owens, Rogers, and
tion, coordinated activity, strengthening exercise, Mazzacco, 1985).
nutrition, weight control, and hydration). Patients In this patient population, clearing oral secretions
with cerebral palsy can be expected to have abnor and coughing maneuvers, require special attention.
mal sleep patterns. First, central cerebral involve Methods of facilitating effective coughing in patients
ment may affect the periodicity of breathing. During with neuromuscular diseases are extremely important
sleep, the effects of such dysfunction are accentu because they constitute life-preserving measures. Sup
ated. Loss of normal periodic breathing and inter ported and unsupported coughing methods are de
spersed sighs impairs mucociliary transport. Secre scribed in detail in Chapters 20 and 21. Whenever
tions may accumulate and contribute to airway possible, deep breathing and coughing is coupled with
obstruction and areas of atelectasis. Second, patients chest wall movement to facilitate maximal inflation of
with cerebral palsy are unable to reposition them the lungs before coughing and maximal exhalation of
selves during the night in response to both car the lungs during coughing. Body positions are varied
diopulmonary and musculoskeletal stimuli. Third, and changed frequently to simulate as much as possi
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548 PART V Guidelines for the Delivery of Cardiopulmonary Physical Chronic Cardiopulmonary Conditions
night. Nighttime oositioning must be prescribed for and well-being and hence
reserve
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30 Chronic Secondary Cardiopulmonary Dysfunction 549
tion of education, aerobic exercise, strengthening ex the strength and endurance of the respiratory muscles
ercises (to maintain or reduce rate of decline), pos (Gross, 1980) and may improve the functional capac
tural correction exercises, chest wall mobility exer ity of some patients. A stronger endurance-trained di
cises, range of motion exercises, body positioning, aphragm wit! not fatigue as readily as an untrained di
breathing control and coughing maneuvers, airway aphragm. Standardizing the resistance of the training
clearance interventions, activity pacing, and energy stimulus alone, however, is not sufficient to produce a
conservation. An ergonomic assessment of the pa training effect. It is essential that flow rate is con
tient's work and home environments may be indi trolled using a gauge.
cated to minimize oxygen demand and energy expen Methods of facilitating effective coughing in patients
diture in these settings. with neuromuscular diseases are extremely important
Education is a principal focus of the long-term because they constitute life-preserving measures. Sup
management of the patient with spinal cord injury. ported and unsupported coughing methods are de
Education includes the reinforcement of preventative scribed in detail in Chapters 20 and 21. Whenever pos
health practices (e.g., infection control, cold and flu sible, deep breathing and coughing is coupled with
prevention, flu shots, aerobic exercise, strengthening chest wall movement to facilitate maximal inflation of
exercise, nutrition, weight control, hydration, pacing the lungs before coughing and maximal exhalation of
of activities, and energy conservation). the lungs during coughing. Body positions are v3lied
Aerobic exercise is an essential component of the and changed frequently to simulate as much as possible
long-term management of the patient with spinal cord shifts in alveolar volume and ventilation and perfusion
injury to optimize the efficiency of oxygen transport that occur with normal movement and body position
overall, including maximizing alveolar ventilation changes (Braun, Giovannoni, and O'Connor, 1984).
and mobilizing and removing secretions. With higher A comprehensive program includes stretching of
lesions, exercise is usually confined to upper-extrem the chest wall and passive range of motion exercises
ity work in the form of wheelchair ambulation. of the shoulder girdle. Maximal insufflations are en
Preservation of upper-extremity muscle function and couraged in optimal body positions. Glossopharyn
minimization of overuse are primary goals from the geal breathing can enable high quadriplegic patients
outset. Patients can maintain adequate cardiopul to be freed from mechanical ventilation for hours at a
monary conditioning with wheelchair exercise, how time. Assisted or unassisted coughing is coordinated
ever, exercise prescription should be conservative to with deep breathing and rhythmic rocking motion.
maximize the benefit-to-risk ratio of cardiopul Manual assisted coughing and mechanical coughing
monary conditioning relying of upper-extremity aids, including functional electrical stimulation and
work. Patients who are able to walk with leg braces insufflation-exsufflation devices, can be useful
and crutches expend considerable energy doing so. A (Bach, 1991; Linder, 1993). The pneumobelt is a de
decision needs to be made regarding the benefits of vice that can facilitate ventilation without a tra
walking at high energy demand vs conserving energy cheostomy (Miller, Thomas, and Wilmot, 1988). This
for other activities. Chest wall exercises can be used device counters loss of abdominal tone and helps pre
and should include all planes of movement with a ro serve normal thoracoabdominal interaction during
tational component. Body positioning to optimize respiration, which is lost because of reduced rib cage
lung volumes and airflow rates is a priority. Breath compliance and increased abdominal compliance.
ing control and coughing maneuvers are essential and Patients with spinal cord injuries, particularly
should be coupled with body movement and position those with high lesions, require prophylactic man
ing. Coordination of respiration with aerobic activity agement, given their risk of developing life-threat
and wheeling is taught to maximize work output. ening respiratory infections and complications. Pro
Ventilatory muscle training has a role in the long p h y l a x i s s ho uld i n c l u d e flu s h o t s, a v o i d i n g
term rehabilitation of some patients with high spinal polluted, smoky environments, smoking reduction
cord lesions. Ventilatory muscle training can increase and cessation, controlling the types of food eaten
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550 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
and chewing well to avoid choking, regular deep • Educate about cardiopulmonary manifestations
breathing, airway clearance, and frequent move of the late sequelae of poliomyelitis, self-man
ment and change in body positions (even just shift agement, medications, smoking reduction or
ing and taking some deeper breaths while seated in cessation, nutrition, weight control, infection
a wheelchair is beneficial). An optimal time to take control, orthoses, mobility and ADL aids and
deep breaths a n d to c o u g h is during transfers, devices, and the role of a rehabilitation program
which usually are physically exerting and stimulate • Optimize alveolar ventilation
hyperpnea. • Optimize lung volumes and capacities and flow
rates
• Optimize ventilation and perfusion matching
late Sequelae of Poliomyelitis
and gas exchange
Pathophysiology and medical management
• Reduce the work of breathing
The late sequelae of poliomyelitis are reaching epi • Reduce the work of the heart
demic proportions as poliomyelitis survivors from the • Protect the airways from aspiration
late epidemic in the 1940s and 1950s reach 35 to 40 • Maximize aerobic capacity and efficiency of
years after onset. Three types of poliomyelitis were oxygen transport
prevalent during the epidemic in the middle of this • Opti mize physical endurance and exercise ca
century, namely, spinal (the majority of cases), bul pacity
bar, and encephalitic. Many survivors are now pre • Optimize general muscle strength and thereby
senting with disproportionate fatigue, increased peripheral oxygen extraction
weakness, deformity, pain, reduced endurance, and Patient monitoring includes dyspnea, respiratory
breathing and swallowing problems (Dean, 1991; distress, breathing pattern (depth and frequency), ar
Howard, Wiles, and Spencer, 1988), and respiratory terial saturation, cyanosis (delayed sign of desatura
insufficiency (Lane, Hazleman, and Nichols, 1974). tion), heart rate, blood pressure, and rate pressure
Although cardiopulmonary complications were not product. Subjectively, pain, a feature of the late se
associated with the spinal form of poliomyelitis at quelae of poliomyelitis, can be assessed using an ana
onset, late-onset breathing and swallowing complica log scale, perceived exertion is assessed using the
tions can appear as a late effect of the disease (Dean, Borg scale, and fatigue and breathlessness can also be
Ross, Road, Courtenay, and Madill, 1991). In addi assessed using a modified versions of this scale.
tion, these patients may be deconditioned and have Medication that is needed to maximize treatment
poor movement economy (i.e., expend excessive en response is administered before treatment (e.g.,
ergy because of postural deformities) (Dean and analgesia). Knowledge of the type of medication, its
Ross, 1993). Thus delayed-onset cardiopulmonary administration route, and time to and duration of
complications, coupled with the effects of overuse peak efficacy is essential if treatment is to be maxi
and general deconditioning, increases the risk of car mally efficacious.
diopulmonary compromise, reduces the ability to re The primary interventions for maximizing car
cover from these, and increases surgical and anes diopUlmonary function and oxygen transport in patients
thetic risk. with the late sequelae of poliomyelitis include some
combination of education, aerobic exercise, strengthen
PrinCiples of physical therapy management
ing exercises, postural correction exercises, chest wall
The goals of long-term management for the patient mobility exercises, range of motion exercises, body po
with the late sequelae of poliomyelitis include the sitioning, breathing control and coughing maneuvers,
following: activity pacing, and energy conservation. An er
• Maximize the patient's quality of life, general gonomic assessment of the patient's work and home
health, and well-being and hence physiological environments may be indicated to minimize oxygen de
reserve capacity mand and energy expenditure in these settings. Aids
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30 Chronic Secondary Cardiopulmonary Dysfunction 551
and devices are reviewed to optimize energy expendi ported and unsupported coughing methods are described
ture (e.g., electric wheelchair or scooter vs manual in detail in Chapters 20 and 21. Whenever possible,
wheelchair) and to reduce cardiopulmonary distress deep breathing and coughing is coupled with chest wall
(e.g., home mechanical ventilation). movement to facilitate maximal inflation of the lungs
Education is a principal focus of the long-term before coughing and maximal exhalation of the lungs
management of the patient with the late sequelae of dUling coughing. Body positions are varied and changed
poliomyelitis. Education includes the reinforcement of frequently to simulate as much as possible shifts in alve
preventative health practices (e.g., infection control, olar volume and ventilation and perfusion that occur
cold and flu prevention, flu shots, aerobic exercise, with nonnal movement and body position changes.
strengthening exercises, nutIition, weight control, hy Progressive loss of pulmonary function in patients
dration, pacing of activities, and energy conservation). with ventilatory compromise at onset can lead to res
Activity and sleep patterns need to be assessed to en piratory insufficiency. Comparable with other neuro
sure sleep is maximally restorative and not contribut muscular conditions, invasive mechanical ventilation
ing to the patient's symptoms. Functional work capac is avoided. Promising alternatives are nasal and oral
ity and activity tolerance may be increased b y methods of noninvasive assisted mechanical ventila
balancing activity t o rest, and maintaining fatigue tion (Bach, Alba, and Shin, 1989). [n addition, airway
below the patient's critical fatigue threshold, i.e., clearance can be fUlther assisted with manual assisted
threshold requiring prolonged recovery time. coughing, glossopharyngeal breathing, mechanical
Aerobic exercise is an essential component of the exsufflation, and mechanical insufflation-exsufflation
10ng-tenTI management of the patient with the late se (Bach et aI., 1993).
quelae of poliomyelitis to optimize the efficiency of Poliomyelitis survivors with ventilatory compro
oxygen transport overall. The two principal goals of ex mise are comparable with other patients with general
ercise are to optimize cardiopulmonary conditioning ized muscle weakness. Of particular concern in this
and movement economy. Maximizing ventilation with population, however, is the need to establish the role
exercise is limited if the patient has severe generalized of mobilization and exercise as a first line of defense
muscular weakness and increased fatigue. Dispropor in the management and prevention of cardiopul
tionate fatigue and other symptoms experienced by pa monary dysfunction. However, for those patients
tients with the late sequelae of poliomyelitis have been whose late effects are due to overuse, additional exer
attributed to overwork of affected and unaffected mus cise may be detrimental. Modified mobilization and
cles, terminal axon degeneration, and impaired impulse exercise, however, may be prescribed in an interval
transmission (Dean, 1991). Exercise is therefore pre schedule (McArdle, Katch, and Katch, 1991) (Chap
scribed judiciously to provide an optimal aerobic train ter 17). The patient exercises for a period of time and
ing effect without contributing to further otheruse abuse then rests or reduces to a lower intensity of exercise
(i.e., prescriptive parameters based on subjective re to aJlow the muscles to rest. In addition to the multi
sponses using semi-quantitative scales in conjunction tude of benefits of mobilization and exercise on oxy
with objective responses). Walking is the most func gen transport overall, these interventions also opti
tional type of aerobic exercise, however, aquatic exer mize respiratory muscle strength and endurance. If
cise provides a useful medium for patients with lower the patient does not recover within a few hours, the
extremity paresis who require crutches to walk or are mobilization or exercise stimuli was excessive and
confined to a wheelchair. Reducing physical activity should be modified. Chest waH mobility exercises to
and exercise is indicated in some patients to optimize facilitate breathing and coughing may have a role.
aerobic and muscle power. The effect of resting affected Patients with generalized neuromuscular weakness
and unaffected muscles enhances functional capacity. require prophylactic management, given their high
Methods of facilitating effective coughing in patients risk of developing life-threatening respiratory infec
with neuromuscular diseases are extremely important tions and complications. Prophylaxis should include
because they constitute a life-preserving measme. Sup flu shots, avoiding polluted, smoky environments,
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552 PART V Guidelines for the Delivery of Larruopuunonal Physical Therapy: Chronic Cardiopulmonary Conditions
controlling the of food eaten and chewing well and hypercapnia. With severe chest de-
to avoid choking, regular deep breathing, airway of pulmonary
and movement and in and right heart failure can result in a
(even just shifting and taking some situation.
breaths while seated in a wheelchair is benefi
PrinCiples of physical therapy management
cial). An optimal time to take deep breaths and to
cough is during transfers, which usually are The goals of management for the
cally and stimulate hyperpnea. with thoracic rjptt>rrni include the
quality of
and hence physiological
MUSCULOSKElETAL CONDITIONS
Thoracic Deformities
Pathophysiology and medical management
of thoracic
can result from abnonnalities ications, nutrition, weight control, infection con
to congenital deformity, trol, smoking reduction and cessation, and the
acquired disease, and trauma . and role of a rehabilitation program
1988b ). of the chest wall alveolar ventilation
reduces the mobility of the bony thorax, thereby in- VUUlIlILC lung volumes and caDacities and flow
the work of Shallow, rapid breath rates
ing often results. Minute ventilation is increased at the • Optimize ventilation and perfusion
expense of alveolar ventilation. Severe deformity leads and gas
to of the mediastinal stmctures. The heart • Reduce the work of
can be and rotated, impeding its mechanical • Reduce the work of the heart
function. Examples of chronic deformities that im • Protect the airways from aspiration
on pulmonary function are kyphoscoliosis sec • Faci litate
ondary to poliomyelitis, tuberculous and • Optimize secretion clearance
other causes and Other exam- • Maximize aerobic and of
of deformity include traumatic injury of the verte oxygen transport
bral column, ribs, and sternum. Routine cardiopul Optimize physical endurance and exercise
monary assessment should include a musculoskeletal
examination of the spinal column and thoracic cavity. • Optimize muscle and thereby
Normal pulmonary function and gas peripheral oxygen extraction
depend on symmetry of cardiopulmonary anatomy Patient includes dyspnea,
and function. Asymmetry of the chest distress, (depth and frequency), ar
wall interferes with normal lung re terial saturation, (delayed of desatura
gional of ventilation and in the lion), heart rate, blood pressure, and rate pressure
and the distribution of inspired gas (Bake, product. Patients with cardiac
and Grimby, 1976; Sinha and ECG monitoring particularly during exercise. Subjec
compliance and tively, exertion is assessed the
increase in work the elastic resis and breathlessness is assessed usin!l: a modified
tance of the lung are characteristic of kyphoscolio version of this scale.
sis. Altered pressure gradients and uneven lung The primary interventions for maximizing car
movement the may con diopulmonary function and oxygen in pa
tribute to altered lung water balance and impaired tients with thoracic deformity include some combina
lymphatic The effects of tion of aerobic
dead space and shunt may be postural correction
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30 Chronic Secondary Cardiopulmonary Dysfunction 553
tion, chest wall mobility exercises, range of motion Patients with chest wall deformities secondary to
exercises, body positioning, breathing control and neuromuscular conditions require prophylactic man
coughing maneuvers, airway clearance interventions, agement given their high risk of developing life
activity pacing, and energy conservation. An er threatening respiratory infections and complications.
gonomic assessment of the patient's work and home Prophylaxis should include flu shots, avoiding pol
environments may be indicated to minimize oxygen luted, smoky environments, smoking reduction and
demand and energy expenditure in these settings. cessation, controlling the types of food eaten and
Education is a principal focus of the long-term chewing well to avoid choking, regular deep breath
management of the patient with thoracic deformity. ing, airway clearance, and frequent movement and
Education includes the reinforcement of preventative change in body positions (even just shifting and tak
health practices (e.g., infection control, cold and flu ing some deeper breaths while seated in a wheelchair
prevention, flu shots, smoking reduction or cessation, is beneficial). An optimal time to take deep breaths
aerobic exercise, strengthening exercises, nutrition, and to cough is during transfers, which usually are
weight control, and hydration). physically exerting and stimulate hyperpnea.
Aerobic exercise is an csscntial component of the
long-term management of the patient with thoracic de
Osteoporosis
formity to optimize the efficiency of oxygen transport
overall. Maximizing ventilation with exercise in pa
Pathophysiology and medical management
tients with severe deformity may be limited. OptimiZ Osteoporosis is a condition associated with reduced
ing alignment to minimize the cardiopulmonary limita bone mass per unit volume (Smith, Smith, and Gilli
tions of the deformity during physical acti vity, gan, 1991). Age-related bone loss begins earlier and
exercise, and rest is a priority. Chest wall exercises in accelerates f a s t e r in w o m e n , p ar t i c u larly after
clude all planes of movement with a rotational compo menopause, than men. Life-style factors, such as diet,
nent. Body positioning to optimize lung volumes and exercise, and smoking, have a significant role in re
ailtlow rates is a priority. Breathing control and cough ducing bone mass. Caffeine has also been implicated
ing maneuvers are essential and should be coupled as a contributing factor to bone loss secondary to in
with body movement and positioning. If mucociliary creasing urinary calcium loss.
transport is impaired leading to secretion retention, Osteoporosis is classified as idiopathic osteoporosis
postural drainage may need to be instituted, coupled unassociated with other conditions, osteoporosis asso
with deep breathing and coughing maneuvers. ciated with other conditions (e.g., malabsorption, cal
Ventilatory muscle training may have a role in the cium deficiency, immobilization, or metabolic bone
management of patients with reduced inspiratory disease), osteoporosis as a feature of an inherited con
pressures and associated decreases in total lung ca dition (e.g., osteogenica imperfecta or Marfan's syn
pacity and hypoxemia. drome), and osteoporosis associated with other condi
Methods of facilitating effective coughing in pa tions but the pathogenesis is not understood (e.g.,
tients with musculoskeletal deformity are extremely rheumatoid arthritis, alcoholism, diabetes mellitus, or
important because they constitute life-preserving mea chronic airflow limitation) (Wilson et aI., 1991).
sures. Supported and unsupported coughing methods The most common clinical features are vertebral
are described in detail in Chapters 20 and 2l. When pain and spinal deformity resulting from vertebral
ever possible, deep breathing and coughing is coupled compression and collapse. Vertebral bodies tend to
with chest wall movement to facilitate maximal infla collapse anteriorly, contributing to cervical lordosis,
tion of the lungs before and maximal exhalation during thoracic kyphosis, postural slumping, and loss of
coughing. Body positions are varied and changed fre height. Acute episodes may be relieved by restricted
quently to simulate as much as possible shifts in alveo mobility. Straining and sudden changes in position
lar volume and ventilation and perfusion that occur can exacerbate an acute episode. C ardiopulmonary
with normal movement and body position changes. complications of osteoporosis are secondary to spinal
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554 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
deformity, chest wall rigidity, and cardiopulmonary Patient monitoring includes heart rate, blood pres
deconditioning resulting from restricted mobility. sure, and rate pressure product. Patients with cardiac
Osteoporosis is a condition associated with aging dysfunction require ECG monitoring particularly dur
and older age groups. The pain of acute episodes ing exercise. Subjectively, pain and discomfort are as
leads to periods of restricted mobility and significant sessed with an analog scale or modified Borg scale, and
cardiopulmonary dysfunction in older persons (Dean, perceived exertion is assessed using the Borg scale.
1993). Exercise that is weight bearing and loads the Medication that is needed to maximize treatment
muscles around bone maintains bone density and de response is administered before treatment (e.g.,
celerates bone loss thus has a central role in preserv analgesics). Knowledge of the type of medication,
ing bone health. Generally, the growth and remodel its administration route, and time to and duration of
lin g of b o n e d e p e n d s h i ghly on t h e e x e r c i s e peak efficacy is essential if treatment is to be maxi
prescription parameters (e.g., type o f exercise, inten mally efficacious.
sity, duration, and frequency). Bone mineral content The primary interventions for maximizing car
is more closely related to cardiopulmonary condition diopulmonary function and oxygen transport in patients
ing than physical activity level. Furthermore, any with osteoporosis include some combination of educa
detrimental effect of exercise on osteoporosis appears tion, aerobic weight-bearing exercise, strengthening ex
to relate more to malalignment and injury rather than ercises, chest wall mobility exercises, range of motion
activity itself. exercises, activity pacing, and energy conservation. An
ergonomic assessment of the patient's work and home
Principles of physical therapy management environments may be indicated to minimize oxygen de
The etiology of osteoporosis is diverse; thus manage mand and energy expenditure in these settings.
ment needs to consider the underlying pathophysiol Education is a principal focus of the long-term man
ogy and that several factors may be contributing to agement of the patient with osteoporosis. Education in
the presentation of osteoporosis in the same patient. cludes the reinforcement of preventative health prac
The goals of long-term management for the pa tices (e.g., infection control, cold and flu prevention, flu
tient with osteoporosis include the following: shots, smoking reduction and cessation, weight-bearing
• Maximize the patient's quality of life, general aerobic exercise, strengthening exercises, range of mo
health, and well-being and hence physiological tion exercises, nutrition, weight control, hydration, pac
reserve capacity ing of activities, and energy conservation).
• Educate about cardiopulmonary manifestations Aerobic exercise is an essential component of the
of osteoporosis, self-management, medications, long-term management of the patient with osteoporo
nutrition, weight control, smoking reduction and sis to optimize the efficiency of oxygen transport
cessation, infection control, and the role of a re overall. Upright, weight-bearing aerobic exercise is
habilitation program essential to maintain bone density or reduce the rate
• Optimize alveolar ventilation of bone loss. Maximizing ventilation with exercise is
• Optimize lung volumes and capacities and flow limited if the patient has severe generalized muscular
rates weakness and increased fatigue. Chest wall exercises
/" Optimize ventilation and perfusion matching can be used and should include all planes of move
and gas exchange ment with a rotational component. Breathing control
• Facilitate mucociliary transport and coughing maneuvers are essential and should be
• Maximize aerobic capacity and efficiency of coupled with body movement and positioning. Strain
oxygen transport ing, Valsalva maneuvers, and jarring activity and ex
• Opt imize physical endurance and exercise ercise are contraindicated.
capacity Methods of facilitating effective coughing in pa
• Optimize general muscle strength and thereby tients with osteoporosis are extremely important be
peripheral oxygen extraction cause they constitute life-preserving measures. Some
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30 Chronic Secondary Cardiopulmonary Dysfunction 555
patients fracture ribs and vertebrae during coughing. of SLE, self-management, nutrition, weight con
Patients at risk should rely on huffing maneuvers that trol, smoking reduction and cessation, medica
do not require closing the glottis and do not generate tions, infection control, and the role of a rehabil
high intrathoracic pressures (Hietpas, Roth, and itation program
Jensen, 1979). • Optimize alveolar ventilation
• Optimize lung volumes and capacities and flow
rates
COLLAGEN VASCULAR/CONNECTIVE
Optimize ventilation and perfusion matching
TISSUE DISEASES
•
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556 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
cated to minimize oxygen demand and energy expen deficit. Pulmonary hypertension may be a complicat
diture in these settings. ing factor. Broncoal veolar lavage is consistent with
Education is a principal focus of the long-term an acute inflammatory process. Cardiomyopathy is
management of the patient with SLE. Education in associated with ischemia, areas of infarction, and my
cludes the reinforcement of preventative health prac ocardial fibrosis (Gray, 1989). Fibrosis of the con
tices (e.g., infection control, cold and flu prevention, duction system predisposes the patient to conduction
flu shots, smoking reduction or cessation, aerobic ex defects and dysrhythmias. Other cardiopulmonary
ercise, strengthening exercises, nutrition, weight con manifestations include pericarditis with or without ef
trol, hydration, pacing of activities, and energy con fusion and pulmonary and systemic hypertension
servation). An ergonomic assessment of the patient's from renal involvement. Half of patients with sclero
work and home environments may be indicated to derma have renal involvement including intimal hy
minimize oxygen demand and energy expenditure in perphasia, fibrinous necrosis of the afferent arterioles,
these settings. and thickening of the glomerular basement mem
Aerobic exercise is an essential component of the brane. Fibrotic changes and stenoses occur in the
long-term management of the patient with SLE to op small arteries and arterioles systemically. Similar
timize the efficiency of oxygen transport overall, in changes in the lymphatic vessels may obliterate
cluding maximizing alveolar ventilation and mobiliz lymph flow.
ing and removing secretions. Parameters of the Esophageal involvement contributes to regurgita
exercise prescription are based on subjective re tion of gastric contents. which is exacerbated when
sponses, (e.g., discomfort, pain, breathlessness, and the patient is recumbent or bends over. Bloating and
perceived exertion in conjunction with objective re abdominal discomfort may reflect paralytic ileus and
sponses). Optimal types of aerobic exercise include intestinal obstruction. Ascites and fluid accumulation
walking and cycling. Aquatic exercise may be prefer in the gut increases abdominal pressure and en
able for patients with musculoskeletal involvement croaches on diaphragmatic motion.
that precludes walking and cycling. Chest wall exer
cises can be used and should include all planes of
Principles of physical therapy management
movement with a rotational component. Body posi The goals of long-term management for the patient
tioning to optimize lung volumes and airflow rates is with scleroderma include the following:
a priority. Breathing control and coughing maneuvers • Maximize the patient's quality of life, general
are essential and should be coupled with body move health, and well-being and hence physiological
ment and positioning. If mucociliary transport is im reserve capacity
paired, leading to secretion r e te ntion, p o s tural • Educate about cardiopulmonary manifestations
drainage may need to be instituted, coupled with deep of scleroderma, self-management, nutrition,
breathing and coughing maneuvers. weight control, smoking reduction or cessation,
medications, infection control, and the role of a
rehabilitation program
Scleroderma
• Optimize alveolar ventilation
Pathophysiology and medical management • Optimize lung volumes and capacities and flow
Scleroderma is characterized by the overproduction rates
of collagen and progressive fibrosis of cutaneous and • Optimize ventilation and perfusion matching
subcutaneous tissues (Gray, 1989). The cardiopul and gas exchange
monary manifestations of this condition result in in • Reduce the work of breathing
terstitial pulmonary fibrosis with significantly re • Reduce the work of the heart
duced vital capacity, diffusing capacity, and arterial • Protect the airways from aspiration
oxygen tension (Bates, 1989; Wilson et aI., 1991). • Facilitate mucociliary transport
Reduced static compliance is the primary mechanical • Optimize secretion clearance
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30 Chronic Secondary Cardiopulmonary 557
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558 PART V Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
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30 Chronic Secondary CardioPIJllJlonary Dysfunction 559
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560 PART V Guidelines ror the Delivery of Cardiopulmonary Physical Therapy: Chronic Cardiopulmonary Conditions
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30 Chronic Secondary Cardiopulmonary Dysfunction 561
environments may be indicated to minimize oxygen ditions presented include muscular dystrophy, hemi
demand and energy expenditure in these settings. plegia, Parkinson's disease, multiple sclerosis, cere
Education is a principal foclls of the long-term bral palsy, spinal cord injury, and the late sequelae
management of the patient with chronic renal insuffi of poliomyelitis. The musculoskeletal conditions
ciency. Education includes the reinforcement of pre presented included kyphoscoliosis and osteoporosis.
ventative health practices (e.g., infection control, cold The collagen vascular/connective tissue conditions
and flu prevention, flu shots, aerobic exercise, presented include systemic lupus erythematosus,
strengthening exercises, range of motion exercises, scleroderma, ankylosing spondylitis, and rheuma
nutrition, weight control, hydration, pacing of activi toid arthritis. Finally, management of the patient
ties, and energy conservation. with chronic renal insufficiency is presented. The
Aerobic exercise is an essential component of the principles of management are presented rather than
long-term management of the patient with chronic treatment prescriptions, which cannot be given with
renal insufficiency to optimize the efficiency of oxy out consideration of a specific patient. In this con
gen transport overall. Maximizing ventilation with text the goals of long-term management of each
exercise is limited if the patient has severe general condition were presented, followed by the essential
ized muscular weakness and increased fatigue. Maxi monitoring required, and the primary interventions
mal oxygen uptake increases in hemodialysis patients for maximizing cardiopulmonary function and oxy
along with improvement in other indices of car gen transport. The selection of interventions for any
diopulmonary conditioning (Painter et aI., 1986). Pa given patient is based on the physiological hierar
tients may decrease or eliminate the need for antihy chy. The most physiological interventions are ex
pertension medications. Exercise carried out during ploited followed by less physiological interventions
hemodialysis treatment sessions is feasible and safe and those whose efficacy is less well documented.
for appropriate patients. Because hemodialysis treat
ments require sessions of several hours multiple
REVIEW QUESTIONS
times weekly, aerobic training (e.g., cycle ergometry)
can be effectively incorporated into treatment time I. Describe the chronic cardiopulmonary patho
(Shallom, Blumenthal, Williams, Murray, and Den physiology secondary to muscular dystrophy,
nis, 1984; Zabetakis et aI., 1982). The exercise pre hemiplegia, parkinson's disease, multiple sclero
scription of patients with blood glucose abnormalities sis, cerebral palsy, spinal cord injury, late seque
and coronary artery disease is modified accordingly. lae of poliomyelitis, kyphoscoliosis, osteoporo
Chest wall exercises can be used and should in sis, systemic lupus erythematosus, scleroderma,
clude all planes of movement with a rotational com ankylosing spondylitis, rheumatoid arthritis, and
ponent. Body positioning to optimize lung volumes chronic renal insufficiency.
and ailflow rates is a priority. Breathing control and 2. Relate cardiopulmonary physical therapy treat
coughing maneuvers are essential and should be cou ment interventions to the underlying pathophysi
pled with body movement and positioning. ology of each of the above chronic conditions
and provide the rationale for your choice.
SUMMARY
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PART VI
Copyrighted Material
Comprehensive Patient Management
in the Intensive Care Unit
Elizabeth Dean
INTRODUCTION
(Bar low, Hayes, and Nelson, 1984; Dean, 1985;
Because cardiopulmonary physical therapy in the in Dean, 1994a; Hislop, 1975; Ross and Dean, 1989;
tensive care unit (lCU) is a specialty in itself, this Schon, 1983; Worthingham, 1960; Zadai, 1986). A
chapter presents some general aspects of clinical and superior knowledge of cardiopulmonary physiology,
nonclinical management in this setting. An overview pathophysiology, pharmacology, and mu ltisystem
of the general goals of treatment and the rationale for disease and its medical management is essential.
prioritizing treatments according to a physiological Clinical decision making in the lCU and ration
hierarchy is described. Both clinical and nonclinical al management of patients is based on a t r i pod
aspects of patient management are presented. Finally, approach: (1) a knowledge of the underlying patho
issues related to the management of the dying patient physiology and basis for general care, (2) the physio
are addressed. logical and scientific evidence for treatment interven
The thrust toward evidence-based p ractice in tions, and (3) clinical e xp e rie n ce (Figur e 31-1).
health care and the development of conceptual bases Quality care is a function of these three areas of
for practice have had major implications for car knowledge and expertise. Evidence-based practice
diopulmonary physical therapy practice in the ICU and excellent problem solving ability will maximize
567
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568 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
Clinical experience Physiologic and scientific The ultimate goals of cardiopulmonary physical ther
evidence for treatment apy treatment in the lCU include the following:
interventions 1. To have the patient alert and oriented to person,
time, and place
FIGURE 31-1
2. To have the patient return to premorbid func
Tripod approach to patient management.
tional level to the greatest extent possible
3. To reduce morbidity. mortality, and length of
the benefit-to-risk ratio of cardiopulmonary physical hospital stay.
therapy interventions (Riegelman, 1991). As a precursor to achieving these three overriding
goals, the immediate goals initially relate to the attain
ment of optimal oxygen transport and hence car
SPECIALIZED EXPERTISE OF THE
diopulmonary function and secondly relate to the at
leu PHYSICAL THERAPIST
tainment of optimal musculoskeletal and neurological
Effective clinical decision making and practice in the function. In the lCU the physical therapist must recog
ICU demands specialized expertise and skill including nize the implications of cardiopulmonary insuffi
advanced, current knowledge in cardiopulmonary and ciency on neuromuscular status and that apparent im
multisystem physiology and pathophysiology, and in pairment of neuromuscular status in not necessarily
medical, surgical, nursing, and pharmacological man indicative of neurological dysfunction. Rather, re
agement (see the box on p. 569). Physical therapists in duced cardiac output and blood pressure, hypoxemia,
the lCU need to be first-rate diagnosticians. Given the hypercapnia, and increased intracranial pressure (lCP)
multitude of factors that contribute to impaired oxygen may be indirectly responsible for these changes.
transport (Dean, 1983; Dean, I 994b; Dean, 1994c), the
physical therapist must be able to analyze these to de
Restricted Mobility and Recumbency
fine the patient's specific oxygen transport deficits and
problems. Therefore the lCU physical therapist must be Hospitalization particularly in the ICU is associated
capable of integrating large amounts of objective infor with a considerable reduction in mobility (i.e., loss of
mation quickly, interpreting this information, and inte exercise stimulus), and recumbency (i.e., loss of grav
grating it to provide the basis for a treatment prescrip itational stimulus) (see Chapters 17 and 18). These
tion (i.e., the specific selection, prioritization, and two factors are essential for normal oxygen transport;
implementation of treatment interventions) (Cutler, thus their removal has dire consequences for the pa
1985). The integration and interpretation of the vast tient with or without cardiopulmonary dysfunction.
amount of multiorgan system data is perhaps the single In terms of a physiological hierarchy of treatment
most important skill in ICU practice and treatment pre interventions (see Chapter 16), exploiting the physio-.
scription. With this database, the physical therapist logical effects of acute mobilization, upright position
must identify the indications for treatment, contraindi ing, and their combination, are the most physiologi
cations, and optimal timing of interventions. The condi cally justifiable primary interventions to maximize
tion of the ICU patient can change rapidly. The physical oxygen transport and prevent its impairment.
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31 Comprehensive Patient Management in the Intensive Care Unit 569
Detailed, c omprehensive knowledge of cardiopulmonary physiology and pathophysiology, and phar macology .
Thorough working knowledge of the monitoring systems routinely used in the ICU and an understanding of the inter
pretation of the output of these mon itoring systems ( e. g. , ECG, arterial blood gases, fluid and e lectrolyte balance,
hemodynamic monitoring, chest-tube drainage systems, intracranial pressure m onitoring ). This information is an
integra l component of the physical therapy assessment of the und erlying problems, and for selecting, prioritizing.
and progressing or modifying treatment.
E xte nsive expertise in c ardiopulmonary assessment and treatment presc ription : preferably a minimum of 2 to 3 years
experience in ge ne ral medicine and surgery.
Detailed understanding of multisystem physiology and pathophysiology and the cardiopulm onary manifestations of
systemic disease.
An ability to practice effectively under pressure and in often apparently congested, suboptimal working conditions.
Knowledgeabh:: regarding all emergency procedures including those for respiratory and cardiac aITest, equipment. or
power failure.
K nowledge abl e rega rding the paging system used in the unit for contacting the physical therapist when she or he is
out of the unit and out of the hospital . On-call service, 24 hours a day. 7 days a week is a co mmon practice and
should be considered in units without this service.
Sensiti vity toward each patient's psychosocial situation, culture , and values, and active involvement of the patient
and family in clinical decision making whenever feasible.
Superior communication skills (e.g., ability to work coop era tively with other members of the lCU team ( see Figure
31-2) and give ve rba l prescntations and discuss patients at rounds).
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570 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
Stroke volume and cardiac output Hydration and nutritional status: deficiencies. obe
sity, or asthenia
Total lung capacity
Recency of onset and course of present condition
Vital capacity
Existing or potential medical instability
Functional residual capacity
Indications or necessity for intubation and mechani
Residual volume
cal ventilation
Forced expiratory volumes
Invasive monitoring, lincs. leads. anel catheters
Airway resistance
Existencc of or potential for complications and mul
Closing volumes of small airways tiorgan system failure
Arterial oxygen levels Elevated intracranial pressure (lCP) and the need for
ICP monitoring
Cough effectiveness
Risk or presence and site(s) of infection
Preload and afterload and myocardial work
Quality of sleep and rest periods
Myocardial efficiency
Nutritional support during ICU stay
Sympathetic stimulation and decreased peripheral
vascular resistance Pain control regimen
General Physical Therapy Goals Toward Function Optimization in the ICU Patient
Maintain or restore adequate alveolar ventilation and perfusion and their matching in nonaffected and affected lung
fields and thereby optimize oxygen transport overall
Prolong spontaneous breathing (to the extent that is therapeutically indicated) and thereby avoid, postpone, or mini
mize need for mechanical ventilation
Design a positioning schedule to maintain comfort and postural alignment (distinct from therapeutic body positioning
to optimize oxygen transport)
Maintain or restore general mobility, strength. endurance, and coordination, within the limitations of the patient's
condition and consistent with the patient's anticipated rehabilitation prognosis (distinct from therapeutic mobiliza
tion to optimize oxygen transport)
Maximally involve the patient in a daily routine including self-care, changing body position, standing, transferring,
sitting in a chair, and ambulating in patients for whom these activities are indicated
Optimize treatment outcome by interfacing physical therapy with the goals and patient-related activities of other
team members, coordinating treatments with medication schedules. and treating the patient specifically. based on
results of objective monitoring available in the ICU and subjective findings
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31 Comprehensive Patient Management in the Intensive Care Unit 571
before treating the ICU patient is presented in the scribed in Chapter 17 and relate primarily to the sta
box on p. 570, at top right. tus of the cardiopulmonary, neuromuscular, and mus
culoskeletal systems. In the ICU the negative physio
logical effects of immobility are amplified in severely
Function Optimization
ill and older patients. A primary objective of the
Function optimization refers to promoting optimal physical therapist, therefore, is to avoid or reduce
physiological functioning at an organ system level, as these untoward effects on the patient's recovery and
well as promoting optimal functioning of the patient length of stay in the ICU. Specifically, these goals in
as a whole. In critical care, primary goals related to clude reducing the deleterious effects of immobility
function optimization are initially focused on car and pathology on cardiopulmonary and neuromuscu
diorespiratory function. With improvement in oxygen lar function and reducing the risk of deformity and
transport, increased attention is given to optimal decubiti. The negative sequelae of relative confine
functioning of the patient with respect to self-care, ment are largely preventable. Particular care must be
self-positioning, sitting up, and walking. General taken to avoid pressure sores because these signifi
physical therapy goals related to function optimiza cantly increase the risk of infection and deterioration.
tion are shown in the box on p. 570, at bottom. Physical therapists and nurses need to examine rou
tinely for sites of redness, pressure, and potential skin
lesions in every patient, regardless of expected length
Prophylaxis
of stay in the ICU (Stillwell, 1992). The texture of
General aspects of patient care related to physical bed coverings, their smoothness, bunching of the bed
therapy practice include the role of prophylaxis or gown, or irritation from lines and catheters to the pa
prevention. The complications of immobility are de tient need to be routinely monitored.
Detailed knowledge of the patient's history, including the differential diagnosis on admission to the rcu, and rele
vant past medical. surgical, and social histories
Detailed understanding and knowledge of the medications administered to the patient, their indications. and side ef
fects, especially those affecting response to physical therapy
Knowledgeable about the stability of vital signs since admission, including heart rate and rhythm, respiration rate and
rhythm. blood pressure, skin color, core temperature, and hemodynamic stability
Detailed knowledge of relevant findings of laboratory tests, procedures, and biopsies, including arterial blood gases,
blood analysis, fluid and electrolyte balance, ECG, x-ray, thoracentesis, central venous pressure (CVP), left arttial
pressure (LAP), pulmonary artery wedge pressure (PAWP), microbiology and biochemistry reports, and urinalysis
If the patient is ventilated, detailed understanding of the rationale for the ventilatory mode and parameters used
With respect to establishing a patient database, do the following: (I) Conduct a thorough, detailed clinical assessment
specific to the patient's condition(s), including inspection, palpation, percussion, and auscultation of the chest, as
well as a neuromusculoskeletal assessment to rule out any secondary effects of cardiopulmonary dysfunction and
to establish rehabilitation prognosis. (2) Establish a physical diagnosis and problem list and prioritize the treatment
goals and overall treatment plan. (3) Determine the optimal assessment and treatment outcome measures and be
knowledgeable about their interpretation. (4) Conduct serial trend measurements to predict the patient's oxygen
transport reserve capacity before treatment and stressing the oxygen transport system
As treatment progresses, record objective and relevant subjective treatmenl outcome measures and revise treatment
goals as indicated by the patient's progress
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572 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
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31 Comprehensive Patient Management in the Intensive Care Unit 573
physical therapist can augment the effects of these In addition, narcotics tend to have significant multi
agents and optimize physical therapy treatment re system effects rather than localized effects. Because
sponse when treatments are coordinated with medica physical therapy is the most physiological and nonin
tion schedules. Most medications have optimal vasive intervention available to the ICU patient, it be
dosages for any given patient, optimal sensitivity, and hooves the physical therapist to ensure that all other
peak-response time. Most medications have side ef pharmacological agents that are effective and more
fects. Side effects may cause deterioration in the pa selective than narcotics in achieving the desired ef
tient's condition, create apparent signs and symptoms fect have been considered.
suggestive of other disorders, or alter response to
treatment. The physical therapist therefore needs to
TREATMENT PRESCRIPTION IN THE ICU
identify the medications each patient is taking and
their side effects. Physical therapy treatments in the ICU are judiciously
Certain medications, such as bronchodilators, selected in a goal-specific manner. As a general
sedatives, mucolytic agents, antianginal medications, guideline, treatments descend in a physiological hier
and analgesics, help the patient to be able to cooper archy. Mobilization, exercise, and body positioning
ate during treatments. Special consideration must al should be exploited first with respect to their direct
ways be given to the different peak-response times of and potent effects on oxygen transport overall. At the
medications used in the ICU. The patient is willing to other end of the hierarchy (i.e., least physiological in
cooperate more actively in the treatment if pain is re terventions that have a more limited effect on the
duced, breathing is easier, and mucus is easier to steps in the oxygen transport pathway) are conven
clear. A better treatment effect is therefore more tional interventions, such as manual techniques.
likely. These advantages result in more effective use Mobilization and exercise can be prescribed to ef
of the physical therapist's time, and often a shorter, fect three physiologically distinct outcomes based on
more cost-effective, efficacious treatment. their acute effects, their long-term effects, and their
Certain other medications may prevent close moni preventative effects (see Chapter 17). The treatment
toring of patients during exercise and activity. Patients prescription needs to focus on which specific effects
on beta-blocking agents, for example, will not show of mobilization and exercise are required to reverse
the normal changes in heart rate and blood pressure in or mitigate deficits in the oxygen transport pathway
response to exercise. In addition, beta-blockers con or prevent impaired oxygen transport. The treatment
tribute to fatigue. Caution must therefore be observed prescription is different in each case.
when prescribing exercise for these patients. Another Unlike other patient care areas, the frequency of
classification of drugs called vasopressor agents help treatments may range from one to several treatments
regulate blood pressure and heart rate. Patients on daily. The frequency depends on the patient's spe
these agents may also exhibit abnormal exercise re cific treatment goals, the aggressiveness of treatment
sponses. Hence monitoring vital signs to assess treat indicated, interfering related problems and their man
ment response may be of limited value for patients on agement, patient cooperation, and tolerance for the
drugs acting on the cardiovascular system. physical therapy treatments prescribed. The patient's
Narcotics is a commonly used classification of oxygen reserve capacity needs to be assessed to en
drug used in the ICU and are often administered sure that the patient can meet the demands of exercise
jointly with sedatives and tranquilizers. Despite their stress. The physical therapist needs to assess the pa
beneficial effects on pain relief, narcotics of any clas tient's tolerance with respect to duration, intensity,
sification of pharmacological agents and particularly and frequency of treatments, as well as prescribed ex
in combination with other sedative type drugs antago ercise. Objective and subjective measures of the pa
nize and often prohibit physical therapy treatments tient's tolerance to the initial assessment and the ob
because of the patient's reduced arousal, monotonous servations of other members of the team help to
ventilation, and inability to cooperate with treatment. establish this baseline.
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574 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Thel'3py: Intensive Care
Treatment goals and interventions are described in progress notes during the ICU stay in order that the team
Part III. Interventions frequently used in the ICU in responsible for the patient after discharge is able to con
clude those related to mobilization and exercise, body tinue management with reduced risk of disruption of
positioning, breathing control and coughing, mucocil care or regression of the patient's condition. The patient
iary transport and mucous clearance interventions, should be consulted, if possible, and informed at all
such as deep breathing and coughing maneuvers, times of his or her progress and plans made by the team
chest wall mobilization, postural drainage, percussion, and family. The patient should be given as many
vibration, shaking, rib springing, relaxation, body choices as possible about his or her care and be actively
alignment, and general strengthening exercises. These involved in long-term planning.
interventions are the mainstay of cardiopulmonary
physical therapy. Intensive care physical therapy de
NONCLINICAL ASPECTS OF THE MANAGEMENT
mands particular skill in selecting, prioritizing, and
OF THE ICU PATIENT
applying the particular interventions that can effect
Team Work
the optimal treatment outcome in the shortest time in a
given critically ill patient. For example, a common Comprehensive patient care in the ICU includes some
scenario in the ICU is the physical therapist's attempt nonclinical activities. Team work is the cssence of
ing to reduce or reverse the adverse changes observed optimal patient care, particularly in the ICU. The
in blood gases; that is, falling Pao2 levels and increas physical therapist interacts frequently with other team
ing Paco2 levels in the patient for whom intubation is members regarding observations and changes in the
being seriously considered if improvement is not ob patient's condition, treatment goals, and treatment re
served soon. The focus of treatment for such a patient sponse (Figure 31-2). In addition to providing therapy
is delineated into two parts. The physical therapist for patients, the physical therapist is often consulted
first focuses on optimizing oxygen transpOit and car regarding ambulation, body positioning, lifting, trans
diopulmonary function of the involved lung fields and ferring, chair sitting, and self-care.
second on maintaining optimal cardiopulmonary func
tion of the uninvolved lung fields.
Infection Control
Contraindications and the awareness of potential ad
verse effects of cardiopulmonary physical therapy are Personal hygiene and good hygienic practice on the
particular concems in the ICU. The physical therapist part of the physical therapist cannot be overempha
needs to be well-versed about these. Treatments need to sized. Patients in the ICU are usually prone to infec
be modified to achieve an optimal treatment effect with tion. Meticulous hand washing with an antiseptic de
out posing a hazard to the patient. Herein lies one of the tergent between patients is essential. Soaping for 30
many challenges of intensive care physical therapy. seconds or more with a thorough scrubbing motion and
followed by thorough rinsing should be carried out.
After contact with infected wounds, saliva, wounds,
Discharge from the ICU
blood, pus, vomitus, urine, or stool, the physical thera
To be recommended for discharge from the ICU, the pist must be particularly conscientious about washing
patient should not require cardiopulmonary physical immediately. Given the concerns regarding HIV infec
therapy more than every 4 to 6 hours. The patient tion and AIDS, physical protection, including gown
should be breathing spontaneously and independently ing, gloving, capping, and masking, should be routine.
and elicit a cough with or without assistance, prefer
ably one that is effective in clearing secretions. If
Recognition of the Patient as a Person
alert, the patient should be moving purposefully in
bed before transfer. Although constraints do exist in the high technology
The physical therapist is responsible for documenting atmosphere of the ICU, the patient's dignity is ob
the physical therapy treatment priorities and frequent served as much as possible regardless of the reason
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31 Comprehensive Patient Management in the Intensive Care Unit 575
FIGURE 31-2
Team work in the intensive care unit is essential to facilitate communication and patient
treatment. A, Physical ther<lpist and nurse "bagging" and suctioning the patient. B, Two persons
positioning for dependent, heavy patients prior to portable chest x-ray. C, Respiratory care
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576 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
FIGURE 31-3
An overview of an rcu room. Note large window area and openness of room. Windows help
patients orient to day and night.
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31 Comprehensive Patient Management in the Intensive Care Unit 577
May experience pain. acute loneliness. and fear tient and those around him or her.
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578 PART VI Guidelines for the Delivery of Cardiopulmonary Physical The.-apy: Intensive Care
References
Dean. E" & Ross, J. (1992). Discordance between cardiopulmonary
Andreoli, K.G .. I·owke,. V.K., Zipes , D.P.. & Wallace. A.G. (1991). phy iology and physical therapy. Chest. 101. 1694-1698.
COlllprehensi!'e cardiac care, (7th ed.). St Louis: Mosby. Hi slop. J.H. (1975). Tenth Mary Mc M illain lecture. The not-50-im
Barluw, D.H .. H ayes. S.c., & Nelson . R.O. (1 984). the scientist possible dream. Physical Thi'rapy. 55. 1069-1080.
practitioner. research and accountability in clinical (lI1d educa Riegelm an . R.K. (1991). Millillli illg lII e dico l lIliswkes. The art
tion "ettillgs. New York: Pennagon Press . of lIledical decision II/akillg. Boston: Little_ Brown and
Cutler. P. (1985). Problem soil'ing in clinical medicine. from data Company.
to diagnoSis. (2nd cd.). B altimore : Williams & Wilkins. Ross. J .• & D ean . E. (1989). Integrating physiological princi ples
Dean, E. (1983). Research. The right way. Clinical Mal1af'emcnr, into the comprehensive management or cardiopulmonary dys
3. 29-33. function. Physica l Tlltrop),. 69. 255-259.
Dean. E. (1985). Psychobiolugical adaptation model fur physical Schon. D.A. (1983). Til" rejleClil'e practitiollel'. HOlV IJruje.uilllwls
therapy practice. Physical Therapy. 65. 1061-1 06R. thillk ill act io ll. New York: Basic Books.
Dean. E. (1994a). Oxygen tran sport : A physiologically-based con Stillwell. S. ( 1 992 ) . Mosby's critical care lIursill!; referellce, St
ceptual I'ramework for the practice of ca rdiopulmonary physio Louis: Mosby.
ther apy. Physiotherapy. 80, 347-355. Wo rth i ng ham. C. (1960). The de velopment of physical therapy as
Dean. E. (1994b). Physiotherapy skills: Positioning and mobili/.a a profession through research and publica tion . Physical Ther
tion of the patient. In B.A. Webber & J.A. Pryor. (Eds.). Phys apy.40. 573-577.
iother(l!I.1' lor Respimtorr and Cardiac Prnhlellls. Edinburgh: Zadai. C.C. (19 86) . Pathokinesiology: The clinical implications
Churchill Livingstone. from a cardiopulmonary perspective. Physica l Therapy. 66
Dean. E. (1994c). Invited cOlllmental), to "Are incentive spirometry. 368-371.
intermittent positive pressure breathing. and deep breathing exer
cises effectivc in the prevention of pos toperative pull11on ry
complications after upper abdominal surgery? A systematic
ovcrvi w and meta-analysis." Physica l Therapy. 74. 10-15.
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CHAPTER 32
Elizabeth Dean
INTRODUCTION
not treatment prescriptions. Rather, each patient must
This chapter presents the principles of cardiopul be assessed and treated individually taking into con
monary physical therapy in the management of criti sideration all factors that contribute to impaired oxy
cally ill patients with primary cardiopulmonary dys gen transport (i.e., immobility, recumbency, extrinsic
function that can lead to cardiopulmonary failure. The factors related to the patient's care, intrinsic factors
categories of conditions presented are obstmctive lung related to the patient, and the underlying pathophysi
disease, status asthmaticus, restrictive lung disease, ology) (Chapter 1). For examples of treatment pre
and coronary art ry disease (medical and surgical con scriptions for specific patients refer to the companion
ditions). Each category of condition is presented in volume to this book entitled Clinical case studies in
two parts. First, the related pathophysiology and perti cardiopulmon(/ry phY.licaltherapy.
nent aspects of the medical management of each con
dition are pres nted. Second, the principles of physi
CARDIOPULMONARY FAILURE
cal therapy management are discussed. These are not
Pathophysiology
mutually exclusive for each category because consid
erable overlap may exist when conditions coexist. The heart and lungs work interdependently; thus fail
It should be emphasized that these principles are ure of one organ has significant imp] ications for the
579
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580 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
TABLE 32-1
NERVES AND Curariform drugs Hypophosphatemia Primary Polio Direct injury Motor neuron
MUSCLES Arsenic Hypomagnesemia Metastatic Tetanus disease
Aminoglycosides Myasthenia gravis
Multiple sclerosis
Muscular dystrophy
GuilJain-Barre
syndrome
From Civelliu JM, Taylor RW, Kirby RR: Crilical care, Philadelphia, 1988, JB Lippincolt.
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32 Intensive Care Unit Management of Primary Cardiopulmonary Dysfunction 581
function of the other organ (Vincent and Suter, 1987; PATIENT WITH OBSTRUCTIVE LUNG DISEASE
Weber, Janicki, Shroff, and Likoff, 1983). Insuffi Pathophysiology and medical management
ciency or failure of the cardiopulmonary system
Obstructive lung disease can result in ventilatory fail
refers to the inability of this system to maintain ade
ure and admission of the patient to the intensive care
quate oxygen and carbon dioxide homeostasis.
unit (ICU), or this disease can complicate manage
Pulmonary failure reflects a gas exchange defect or
defect of the ventilatory pump. Table 32-1 shows the ment if the patient is admitted for other reasons
(Boggs and Wooldridge-King, 1993; Un derhill,
classification of pulmonary failure by specific causes
and the mechanisms involved. Some common predis Woods, Froelicher, and Halpenny, 1989). If conserv
posing conditions include primary cardiopulmonary ative management fails or is unlikely to improve crit
conditions, (e.g., chronic lung disease, overwhelming ically impaired oxygen transport and gas exchange
and to adequately remove copious and tenacious se
pneumonia, and myocardial infarction) and secondary
cardiopulmonary conditions (e.g., motor neuron dis cretions, intubation and mechanical ventilation are in
dicated (Chapter 41). Complicating factors include
eases, spinal cord injury, stroke, and muscular dystro
phy) (Chapter 30). The oxygen and carbon dioxide impaired oxygen delivery, polycythemia, impaired
respiratory mechanics secondary to lung damage and
tensions that have been used to define failure are vari
increased time constants impairing optimal inhalation
able because they depend on factors such as premor
and exhalation, flattened hemidiaphragms, rigid
bid status, general health, age, prior blood gas profile,
and the time frame for the development of failure. Ar
terial blood gases and pH are essential in the assess
ment of cardiopulmonary failure, which is usually di
agnosed when the Pa02 falls below 50 to 60 mm Hg
and the PaC02 rises above 50 mm Hg (Shoemaker,
Thompson, and Holbrook, 1984).
Primary cardiac failure reflects failure of the my
ocardium to pump blood to the pulmonary and sys
temic circulations and maintain adequate tissue per
fusion (Austin and Greenfield, 1980). Significant
dysfunction of the left ventricle can lead to pul
monary vascular congestion and cardiogenic pul
monary edema ( i . e . , c o n g e s t i v e h e a r t f a i l u r e )
(Matthay, 1985). Diseases o f the heart that can lead
to failure include significant myocardial damage as a
result of infarction or myopathy, valvular heart dis
ease, and congenital defects.
Both primary pulmonary and cardiac failure can be
classified into acute and chronic stages. The compen
sation mechanisms that occur in the two stages are
distinct. With adequate physiological comp:nsation,
patients can tolerate some degree of chronic failure.
Patients with a mild degree of failure can live I'eason
ably independent lives. Moderate failure is signifi
cantly more limiting, thus these patients may require
home ventilatory support (e.g., supplemental oxygen
and nighttime ventilation), and severe failure requires FIGURE 32-1
hospitalization and mechanical ventilatory support. Patient receiving mechanical ventilation.
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582 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
banel-shaped chest wall, increased accessory muscle tion from the oropharyngeal cavity can be reduced by
use and work of breathing, reduced diffusing capac suctioning through the airway with the cuff of the air
ity, impaired mucociJiary transport, secretion accu way inflated, in addition to suctioning the oropharynx'
mulation, ineffective cough mechanism, increased after suctioning via the airway.
oxygen consumption, increased work of the heart, Suctioning can be performed frequently in a pa
and general debility and weakness. tient with an artificial airway and is less traumatic.
The goal of intubation and mechanical ventilation Patients should be suctioned only as indicated be
is to provide an airway and adequate alveolar ventila cause this procedure can produce significant desatu
tion, which is based on arterial blood gas analysis. A ration (up to 60%), particularly in the ventilated pa
tidal volume and a respiratory rate that provide satis tient (Walsh, Vanderwarf, Hoscheit, and Fahey,
factory blood gas and pH values are established and 1989). Administration of 100% oxygen for 3 minutes
maintained unless the clinical condition changes. The before and after suctioning (i.e., hyperoxygenation)
precise regulation of mechanical ventilation helps to minimizes this desaturation effect. This can be ac
restore adequate blood gases and cardiopulmonary complished by manually bagging the patient before
function, reduce the work of breathing, rest fatigued treatment (i.e., manual hyperventilation) or by preset
ventilatory muscles, and provide an optimal fraction ting the mechanical ventilator (Fell and Cheney,
of inspired oxygen (FIo2) and humidification (Figure 1971). Risk of aspiration of gastric contents is re
32-1) (Wilson, 1992). duced by the use of a nasogastric tube.
Minute ventilation can be seriously impaired with a A common cause of acute rcspiratory failure is ad
leak in the mechanical ventilator circuitry. The tube vanced chronic airflow limitation (Civetti, Taylor, and
connecting sites are often the sites of air leakage. Com Kirby, 1988). The pathophysiological deficits include
plete disconnection at the endotracheal or tracheostomy significant loss of alveolar tissue, increased compli
connection may occur in those patients with high pul ance of alveolar tissue, hyperintlated chest wall, im
monary resistance. Close monitoring of the exhaled paired respiratory mechanics, flattened hemidi
tidal volume and end tidal carbon dioxide will ensure aphragms, impaired breathing efficiency, and reduced
the patient is receiving sufficient ventilation. diffusing capacity. Proportional changes in lung vol
Positive end expiratory pressure (PEEP) is useful umes and capacities in patients with chronic airway
in promoting greater opportunity for gas exchange at limitation compared with healthy persons are pre
end-cxpiration in mechanically ventilated patients. sented in Figure 8-5, p. I SO. The primary abnormality
However, venous return, myocardial perfusion, and is a significantly increased residual volume and inspi
cardiac output may be impaired during positive pres ratory reserve volume and hence total lung capacity.
sure ventilation with PEEP administration (Jardin, et Failure of oxygen transport ensues secondary to venti
aI., 1981; Kumar, Pontoppian, Falke, Wilson, and lation and perfusion mismatch, ventilatory muscle fa
Laver, 1973). Excessive stimulation to cough in these tigue, reactive pulmonary hypertension, and right ven
ventilated patients shOUld be avoided because this ac tricular failure. Correcting the complications of
centuates the cardiovascular side effects of PEEP. respiratory failure, however, is often more problem
Continuous positive airway pressure (CPAP) can atic than treating the specific cause. Hypoxemia and
maintain airway patency during spontaneous ventila hypercapnia are often present. Hypoxemia is usually
tion. This mode of ventilation, however, seems to be improved with supplemental oxygen in the absence of
prcferred in children, whereas PEEP is used more significant diffusion defect or shunt.
commonly in adults. Cardiovascular complications are among the most
Interfcrence with the gag reflex in the patient with prevalent observed in ventilatory failure. Marked hy
an endotracheal tube increases the risk of aspiration percapnia (increased arterial P(02) with acidemia (re
of the oropharyngeal and gastric contents and can re duced pH) can produce extreme vasodilatation and
sult in pneumonitis and pneumonia. Risk of aspira hypotension resulting from the local action on blood
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32 Intensive Care Unit Management of Primary Cardiopulmonary Dysfunction 583
Nutrition
vessels (Boggs and Wooldridge-King, 1993). Mild
hypercapnia can produce reflex vasoconstriction and Critically ill patients are hypermetabolical. Metaboli
hypertension. Occasionally systemic hypertension is cal demand and oxygen consumption are increased
observed during weaning from the ventilator with the secondary to healing and repair, increased tempera
presence of a moderate degree of hypercapnia. ture, altered thermoregulation and after surgery. Pa
Right heart failure, cor pulmonale, is a well tients with chronic cardiopulmonary limitation are
known complication of chronic lung disease and con often undernourished because of the effort required to
gestive heart failure. Both hypoxia and reduced pH purchase food, prepare, and consume it. Furthermore,
cause pulmonary vasoconstriction and an increase in these patients have an increased oxygen consumption
pulmonary artery prcssure. Consequently, reversing and energy expenditure secondary to the increased
bronchospa sm, hypoxemia, hypercapnia, a n d work of breathing (Petty, 1985; Rochester and Esau,
acidemia can often reduce pulmonary vasoconstric 1984). Without adequate nutrition, patients incur the
tion, lower pulmonary artery pressure, and thereby effects of deconditioning faster, are debilitated, are
improve hemodynamics. less capable of responding optimally to therapy, and
The end stage of respiratory failure results in a pro are more susceptible to infection. Intravenous hyper
gressive increase in airway resistance, work of breath alimentation, or external hyperalimentation, is typi
ing, oxygen consumption, and carbon dioxide produc cally instituted early to maintain optimal nutritional
tion. In areas of bronchial obstruction, marked status and to avoid excessive physical wasting and
alveolar hypoventilation results and ventilation and deterioration. If a tracheostomy has been pelformed,
pelfusion are severely mismatched. Hypoxemia and the patient is able to eat normally.
respiratory acidosis produce reactive pulmonary hy
pertension and further ventilatory failure. Profound
Principles of physical therapy management
carbon dioxide retention, refractory hypoxemia, and The principles of management of acute respiratory
respiratory acidemia may terminate in a fatal dys failure are based on interventions that will enhance
rhythmia (Gibson, Pride, Davis, and Loh, 1977; oxygen transport (i.e., oxygen delivery, oxygen
Macklem and Roussos, 1977; Rochester and Arora, consumption, and oxygen extraction), and facilitate
1983; Vincent and Suter, 1987; Weinstein and Skill carbon dioxide removal (Gallagher and Civetta,
man, 1980; Wcissman, Kemper, Elwyn, Askanazi, 1980). Thus the steps of the oxygen transport path
Hyman, and Kinney, 1989). way that have been identified as impaired or threat
Acidemia from respiratory causes with a pH of ened by the patient's condition (i.e., immobility, re
less than 7.25 is often harmful with respect to dys cumbency, and extrinsic and intrinsic factors in
rhythmia production. Conversely, hypoventilation is addition to the underlying pathophysiology) (Chap
equally harmful, and pH elevations greater than 7.5 ter I) are the focus of treatment. Based on a de
may cause neurological and cardiovascular complica tailed analysis of these factors, treatments are se
tions. In acute respiratory failure with profound lected, prioritized, and applied to optimize the steps
acidemia, intravenous use of bicarbonate is used to in the pathway that are affected. These may include
buffer the hydrogen ion concentration until the under treatments to maximize the patency of the airways,
lying disorder is corrected. Bicarbonate infusion is increase alveolar ventilation, facilitate mucuciliary
guided by frequent pH measurements. transport, facilitate airway clearance, optimize the
Transport of oxygen and carbon dioxide to and mechanical position of the diaphragm, optimize
. from the tissues depends on adequate pulmonary and ventilation and perfusion matching, optimize pH,
systemic circulation. Frequently, blood volume has to eliminate carbon dioxide, optimize peripheral circu
be restored by fluids or blood replacement or both. lation and tissue perfusion, and reduce the work of
Inotropic agents are used to maintain adequate circu breathing and of the heart. To optimize oxygen
lation by augmenting myocardial contractility. transport, the primary goals of physical therapy
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584 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Intensive Care
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32 Intensive Care Unit Management of Primary Cardiopulmonary Dysfunction 585
Body positioning
tremely strenuous for the ICU patient with respect to
oxygen demand, considering that this patient is hy Body positioning is a potent therapeutic intervention
permetabolical. Such activities need to be introduced that promotes optimal oxygen transport and gas ex
gradually and with continuous monitoring to ensure change in two ways; one, from the physiological
the patient does not exceed the prescribed therapeutic benefits accrued from the specific positions them
intensity needcd to maximize oxygen transport. selves, and two, from the physiological hcndits ac
Standing and walking are coordinated with other as crued from physically changing from one position to
pects of the patient's care and should be carried out another (see Chapter 18). Body position can be used
in several stages. Monitoring of the ECG and arterial preferentially to augment alveolar volume, alveolar
saturation of the critically ill patient performing ac ventilation, ventilation and perfusion matching, res
tivities such as standing or walking cannot be piratory mechanics, cough effectiveness, eentral and
overemphasized. By disconnecting these monitors, peripheral hemodynamics and fluid shifts, mucocil
the physical therapist is working blindly and poten iary transport, and secretion clearance (see Chapter
tially dangerously because the leads do not reach or 18). Both ventilation and perfusion are enhanced in
becausc of movement artifact. In anticipation of an the inferior lung fields. Thus in postural drainage po
increased workload, ventilatory parameters for the sitions the superior lung being treated is neither pref
ventilated patients may require adjusting. A greater erentially ventilated nor perfused. The less affected
concentration of oxygen should be delivered for at lung fields therefore may be contributing more sub
least 3 to 5 minutes before the activity and continued stantially to improving arterial gases. Hence the
afterward for 10 minutes or so until the patient has physical therapist must consider the goals of treat
recovered from the increased exertion and the heart ment with respect to pulrnona:-y function in both the
rate and blood pre. sure have returned to within 5% to involved and less-involved lung fields. During pos
10% of baseline values. tural drainage, the length of time in a given position
Active movement has greater therapeutic effect needs to be monitored to avoid drainage of secre
on oxygen transport than assisted or passive move tions into the less involved, functional, inferior lung
ments; thus the benefits of active movements are ex fields and to avoid the possibility of compression at
ploited first. Movement recruiting large muscle electasis in the inferior lung (Dcan, 1985; Leblanc,
stress associated with movement of small muscle Although positions can be predicted that will opti
groups or movements requiring excessive dynamic mize ventilation and pert'usion matching, each patient
stabilization (Hanson and Nagel, 1987). If active will respond differently, depending on such factors as
movements cannot be performed or excessively pathology, age, weight, depth of breathing, and me
stress the oxygen transport system, then active as chanical ventilation (Clauss, Scalabrini, Ray, and
sisted movements arc indicated. Passive movements Reed, 1968; Ray et aI., 1974), Thcrefore the patient's
have a role primarily when the patient is paralyzed response to specific positioning must be observed,
or' so hemodynamically unstable that the patient de documented, and objectively monitored with respect
teriorates with active movement. With respect to car to the effect on oxygen transport variables.
diopulmonary benefits, passive movement stimulates Another important goal of body positioning is to
changes in ventilatory and circulatory patterns potentiate position-dependent fluid shifts to optimize
(West, 1995). These can be particularly beneficial in cardiovascular function. For this reason the patient
patients who have significant mobility restriction, should be positioned upright as often as possible. In
however, they should not substitute for active and addition, there are other beneficial effects of the up
active-assisted movements, which are associated right position on pulmonary function (e.g., maximizc
with even greater benefit because they are higher lung volumcs and capacities, minimize alveolar col
order activities on the physiologically based treat lapse, decrcase airway resistance, increase lung eom
ment hierarchy (see Chapter 16). pliancc and, therchy, reduce ventilator system pres
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586 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
sure). To maximize the effect of gravity on promot increased before postural drainage and treatment to
ing fluid shifts, the legs should be positioned depen help compensate for any physical stress imposed
dently at frequent intervals. In a patient who is not by treatment. Oxygen, however, should always be
self-supporting with or without assistance, fluid increased to 100% and inspired for at least 3 min
shifts can be stimulated with a high Fowler's posi utes before and after suctioning. Should arterial de
tion coupled with the use of the bed knee-break. Be saturation be apparent during treatment, oxygen
tween sessions of therapeutic body positioning, a may need to be increased. If the patient is sponta
schedule of four-point turning (supine, left side, neously breathing without oxygen, supplemental
prone, right side) is ideal and should be attempted oxygen may also be indicated during treatment to
even in the ventilated patient if not strictly con avoid desaturation in some patients. Oxygen ad
traindicated (Dean, 1994). ministration must be knowledgeably regulated by
Extreme body positions have been reported to the ICU team based on arterial blood gas results.
have beneficial effects on oxygen transport in pa Severe hypoxemia is known to result in irreversible
tients with acute respiratory failure. The head-down tissue damage within minutes, but hyperoxia can
position has been shown to reduce respiratory distress also produce harmful effects within hours. By max
in some patients with obstructive lung disease imizing alveolar ventilation, gas exchange, and
(Barach and Beck, 1954). The abdominal viscera are ventilation and perfusion matching, supplemental
displaced cephalad, thereby elevating the typically oxygen can be opti mally used and the effects of
flattened hemidiaphragms and placing them in a me acidemia minimized.
chanically advantageous position. This effect may be Treatment for respiratory acidosis is aimed at in
mimicked in other body positions by manual abdomi creasing alveolar ventilation to improve the ex
nal compression and abdominal binders. In some pa change of carbon dioxide and oxygen. Because the
tients, however, the additional load imposed by the r e s p i r a t o r y c e n t e r is d e p ressed by i n creased
increased intraabdominal pressure on the underside amounts of carbon dioxide (carbon dioxide narco
of the diaphragm may inadvertently increase the sis), the lowered oxygen tension of the blood be
work of breathing and increase respiratory distress. comes the stimulus for respiration. If the patient in
The prone position has been reported to be beneficial hales high c o n c e n t r a t i on s of oxygen, the
in patients with acute respiratory fai I ure (Douglas, stimulation for respiration may be removed. For
Rehder, Beynen, Sessler, and Marsh, 1977; Piehl and this reason, oxygen is never given to patients with
Brown, 1976). A variant of the prone position, semi carbon dioxide narcosis.
prone, may be more beneficial in some patients by re Low flow oxygen (I to 3 Llmin) is given to a pa
ducing intraabdominal pressure. In addition, the tient with chronic pulmonary disease who maintains a
semi-prone position may be safer and more comfort chronically elevated arterial Pe02 in the presence of
able for the mechanically ventilated patient. The pre arterial hypoxemia. If intermittent positive pressure
scription of any body positioning must be based on breathing is indicated, compressed or room air is used
its anticipated benefits on oxygen transport. The instead of oxygen in this situation.
more extreme positions should be introduced in pro Severe hypoxemia usually suppresses cardiac out
gressive stages and the patient's response monitored put to some degree. Cardiac output may be further
to ensure the response is favorable. compromised immediately after a patient is placed on
a mechanical ventilator because of impaired venous
return by the elevated transpulmonary pressure
Supplemental oxygen
(Jardin et aI., 1981). An attempt is made to carefully
Supplemental oxygen is usually administered con balance ventilation with an optimal or adequate car
tinuously, whether the patient is ventilated or not, diac output by shortening inspiratory time and by
to maintain Pa02 level within an optimal range minimizing transpulmonary pressures by using lower
(Dantzker, 1991). Oxygen concentrations can be tidal volumes.
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32 Intensh'e Care Unit Management of Primary Cardiopulmonary Dysfunction 587
Bagging
Dean and I 992a), Thus these less
Dr�lctl:ce in some ICUs is bagging, A self less physiological conventional proce
is temporarily connected to manual should be considered
are manually inflated for a few and after other more supported and
breaths, The purpose of the is to pro physiological treatments have been Fur-
vide some breaths during treatment, to because of their documented adverse ef
maintain some degree of end-expiratory fects, it is essential that the patient be continuously
pressure, to assess lung and to facilitate monitored for safety reasons and to establish a favor
the effect of instillation of a small volume of saline able treatment outcome, For the unconscious or para-
solution into the tracheobronchial tree to loosen se patient, the ventilator or self-inflating bag can
cretions, Bagging must be performed Ag be used to increase inflation volumes, Research is
can The use needed to examine the role of and the effect
in conjunction with is contro of this on mucous removal.
versial. Some clinicians to bag the patient after
suctioning to a void the of the
Instillation
pressure pushing the mucus distally, Others maintain
that because of the adherent quality of the mucus to Instillation is another procedure that should be used
the walls of the and the dilatation of the air in A mucolytic effect of saline
ways in response to positive pressure, does has not been well established, Beneficial
not propel the mucus distally, Rather, it is believed however, may be more apparent in neonates,
that before suctioning promotes air entry dis
tal to the mucous and movement of cen
Mucociliary transport and secretion clearance
on expiration,
Certain body prob The patient in failure needs atten
lem when a ventilator is used, tion to fluid balance to carefully hydration
The of the ventilator is greatly reduced and fluid volume, Inhaled humidified air is a
when the head is below the hips cant additional source of fluid, Normally the
because of an increase in total pulmonary resistance alveolar gas is saturated with water vapor. The
caused the pressure of the abdominal contents, of the tracheobronchial tree is therefore
Therefore the use of a bag from erosion and potential infection, This is partiCLI
may be to maintain pressure when larly important in the requmng suc
from one 10 another and during some pos tioning, The effect of humidification can be assessed
tural positions, tidal volume can by the of the secretions, Thick
be maintained an assistant while the pllysical ther secretions suggest humidification may be
aids the patient with bronchial With and the patient may be systemically
the use of the the physical therapist If the effects of mobilization on
needs to ensure the is adequately ventilated port and secretion accumulation have been
and takes a than tidal breath every minute or and further secretion clearance is
so, As soon possible, breathing is en may be indicated, Postural may be
couraged in conjunction with postural drainage, The contraindicated in patients with unstable vital
small airways dilate on and cause and is usually contraindicated immediately after feed-
mucus to peel away from the walls; thus, during expi and meals, In some however, pa
mucous are moved toward the trachea, tients on continuous 24-hour tube are
to which chest wall percussion, shaking, after has been discontinued for 15 minutes.
and vibration facilitate this movement is l!l The cuff in the artificial
the literature (KiriJloff, and Maz- A sequence
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588 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
and vibration may be indicated in conjunction with clearance. Patients should not breathe below the end
postural drainage. Manual techniques have been asso of normal tidal ventilation to avoid airway closure.
ciated with desaturation, atelectasis, musculoskeletal
trauma, discomfort, cardiac dysrhythmias, and arrest
Weaning from the mechanical ventilator
(Kirilloff, et aL, 1985); therefore these techniques
must be applied rationally and with attention to all The physical therapist and the respiratory therapist
monitoring systems and changes in signs and symp are primarily responsible for weaning the patient off
toms. The precise sequence, the duration, intensity, mechanical ventilation. Thus coordinating their goals
and frequency of treatment is based on treatment out and working together to ensure the weaning process
come rather than ti me. The application of manual is carried out expediently and with the least risk of
techniques in the head-down position is contraindi weaning complications (e.g., postextubation atelecta
cated in patients with acute myocardial infarction and sis, aspiration and hypoxemia) is a priority (Marini,
increased intracranial pressure. Relative contraindica 1984; Shoemaker et aI., 1984). Blood gas analysis
tions include hemorrhage, bronchopulmonary fistula, and pulmonary function provide the indications for
acute chest trauma, lung abscess, and gastric reflux weaning. Ideally, the patient's spontaneous tidal vol
(Boggs and Wooldridge-King, 1993). ume should approximate that delivered by the venti
The specific postural drainage positions to be used lator. Forced vital capacity should be two to three
are determined based on the pathology, x-ray, and times the patient's required tidal volume (Figure
clinical examination. The recommended positions for 32-2). Weaning is not usually indicated if the patient
the bronchopulmonary segments involved should be requires PEEP greater than 5 cm H20 or FIo2 greater
approximated as closely as possible (Chapter 19) and than 0.4. In addition, patients who are unable to gen
only modified if there are clear indications to do so. erate a negative inspiratory pressure of -20 mm Hg
Frequently, specific positioning in the ICU is com or greater are unlikely to be able to generate suffi
promised as a result of the patient's status, intoler cient intrathoracic pressures for deep breathing and
.
ance to lying flat or being tipped, or limitations im airway clearance and thus are poor candidates for
posed by the monitoring apparatus or ventilator. weaning. Minute ventilation and maximum voluntary
ventilation can be measured at bedside and contribute
to the decision whether to wean. Although weaning
Breathing and cOl)ghing maneuvers
protocols differ depending on the patient and the ven-
If the patient is nonventilated or recently extubated,
body positioning and breathing and coughing maneu
vers are emphasized to promote mucociliary transport
and secretion clearance (Bennett, Foster, and Chap
man, 1990), decrease minute ventilation and respira
tory. rate, increase tidal volume, and improve arterial
blood gases (Barach, 1974; Casciari, Fairshter, Harri
son, M o r r is o n, Blackhurn, a n d Wi l s o n, 1981).
Breathing exercises are believed to be most effective
if pursed-lips breathing is performed in conjunction
with mechanical pressure applied over the abdomen
(Irwin and Tecklin, 1985; Mueller, Petty, and Filley,
1970). To derive the maximal benefits, breathing and
coughing maneuvers should be performed in body
positions that are most mechanically and physiologi FIGURE 32·2
cally optimal. In addition, they are performed in the Spirometer for bedside measurement of TV, ve, and
postural drainage positions to augment mucociliary minute volume.
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32 Intensive Care Unit Management of Primary Cardiopulmonary Dysfunction 589
tilatory mode used, general guidelines for this com include tachypnea, dyspnea, labored breathing, audi
mon ICU procedure are outlined in the box below. ble wheezing, tachycardia, cyanosis, anxiety, and
panic. If the patient is able to cooperate wilh spiro
metric testing, the degree of reduced vital capacity,
PATIENT WITH STATUS ASTHMATICUS
peak flow, and forced expiratory volume provide in
Pathophysiology and medical management
dices of the severity of airway obstruction (Brunner
Status asthmaticus is a potentially life-threatening sit and Wolff, 1988).
uation (Petty, 1982; Gaskell and Webber, 1988). The Medical management is aimed at administering
pathophysiological features include marked airway re drugs and fluids to reduce hypoxemia with oxygen,
sistance secondary to bronchospasm, edema, and mu decrease airway inflammation and resistance, and
cous secretion and retention. The work of breathing is hence reduce the work of breathing and anxiety. In
markedly increased, resulting in respiratory distress. travenous sodium bicarbonate helps to reverse respi
A cycle results in which the patient becomes more hy ratory acidosis and possibly m e tabolic acidosis
poxemic and hypercapnic secondary to alveolar hy (Civetta, et aI., 1988).
poventilation, 'bronchospasm increases, and reactive
Principles of physical therapy management
pulmonary hypertension may ensue along with a fur
ther incrcase in the work of breathing and anxiety. The prime objective of physical therapy is to optimize
The classical signs and symptoms of a severe asth oxygen transpolt and possibly avoid or delay the need
matic attack that may progress to status asthmaticus for mechanical ventilation. If ventilation becomes
1. An individualized weaning schedule is designed for each patient in which periods of time are spent off the venti
lator and on a T tube thaI delivers appropriate oxygen and humidity
2. The initial time period off the venti lator is carefully selected; mornings are often good times
3. (a) Physical activity should be at a minimum d uring this period (e. g. , not during or after physical therapy. not
after meals. rests, or procedures, and not during family visits) (b) Supplemental oxygen and humidity are given
5. Vital signs. and signs and symptoms of respiratory distress are monitored continuously during weaning
6. The patient is not left unattended in the initial weaning sessions until periods off the ventilator are reliably toler
ated well for several successive minutes
7. (a) Deterioration of vital signs, blood gases. and evidence of distress indicate that the patient will have to return
\0 ventilatory assistance imminently (b) Rest periods of at least an hour are strategi cally interspersed in the
weaning schedule
8. B lood gases are performed at regular intervals (e.g .. 15, 30. 60, 90, and 120 minutes or more or less frequently as
indicated)
9. If blood gases stabilize within acceptable limits during the weaning period and the patient is generally tolerating
the procedure well. the time off the ventilator is increased
10. Patients with underlying cardiopulmonary disease who are older, malnourished, obese, or smoke can be expected
to take longer to be completely weaned from the ventilator
II. Weaning is generally faster in patients who have required a shorter period of mechanical ventilation
12. To hasten the weaning process, intermillent mandatory ventilation (lMV) has been reported to be useful in some
patients. Others, however. have observed that the use of IMV tends to fatigue the patient and delay the patient's
progress in wcaning. Thus IMV must be used cautiously. and individual variability must be considered in terms
of its effectiveness.
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590 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
necessary, prognosis for recovery is poorer (Petty, expiration and to maintain the patency of the
I Physical can augment the medical small airways. and relaxed
management of the with status asthmaticus. In emphasized with periodic
an attempt to avert intubation and mechanical ventila huffing and avoidance of forced maneu
tion the physical therapist coordinates treatment with vers Roth, and J Nunn, Cole
the medications bronchodilators, mus man, Sachithanandan, and Laws, 1965).
cle relaxants. steroids. and supolemental oxygen). Despite ve noninvasive management,
control, en blood gases may deteriorate and mechanical ventila
matching, promotes tion may be inevitable, Relaxation, alveo
mucociiiary and secretion reduces lar ventilation, and reducing airway and ob
and teaches the patient CO coordinate re- struction continue to be the primary however.
with general movement. Cau means of achieving these differ when the patient
tion needs to be observed to avoid stimuli that poten is ventilated. Optimal prescriptive body
tiate bronchospasm and deterioration of the positioning is the intervention of choice. Secretion
condition that increase clearance is achieved by judicious suctioning. Suc
tory distress rather than relieve it, chest wall percus tioning is as required because it can con
forced maneuvers, bag tribute to reduced oxygenation, collapse, and
and possibly instillation). Attention to relaxation atelect asis, increased arousal, increased work o f
and reduction of excessive oxygen demands is a and generallv increased respiratory distress,
as was described for the patient with chronic air
flow limitation. Certain positions may have to '
PATIENT WITH RESTRICTIVE LUNG DISEASE
be avoided, for because of the in
colerance and exacerbation of symptoms in those po-
Pathophysiology and medical management
sitions. Because of the relationship of altered pul Acute failure can be associated with
positioning mary restnctlve disease interstitial
in patients in distress) must be monary fibrosis). This is distinct from restrictive de
cautiously within the patient's tolerance. fects secondary to neuromuscular and musculoskeletal
Those body positions that reduce respiratory distress diseases Guillain-Barn
and the work of and maximize alveolar ven and neuromuscular
tilation, oxygen saturation and blood gases, are the neuromuscular disorders that can respira
of choice.
tory failure in the absence of underlying primary
problems in status asthmaticus are alveolar
(Chapter 33). If the will
airway obstruction secondary t o likely be on assistance.
bronchospasm, mucosal edema, and secretions. Thus dysfunction may, the
maximizing alveolar ventilation and mu- management of admitted to the ICU for rea
transport are priorities 1989). Other sons other than cardiopulmonary disease. The lung
include significantly increased work of the chest or both may be involved.
because of an inefficient breathing pattern The underlying cause of failure may there
and an ineffective cough. The physical therapist coor fore reflect ventilatory failure, gas
dinates treatment with the medications to fa failure, or both. The restrictions ro
cilitate mucociliary and clear monary function need to be identified and treated in
a n c e of s e c r e t i o n s w i t h b r e a t hi n g c o n t r o l and dividually t o treatment. Obstructive and re
modified chest wall percussion. and huff stricti ve patterns of cardiopulmonary frequently
Obtaining a productive cough thus the contribution of both types of defects
is a to a patient's oxygen should be determined.
Typically, in restrictive lung disease, all lung volumes
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32 Intensive Cafe Unit Management of Primary Cardiopulmonary Dysfunction 591
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592 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
however, greater cardiopulmonary stress occurs with Optimizing oxygen transport using body positioning
upper limb exercise; thus heart rate, ECG, and blood and then nonphysiological interventions may then
pressure need monitoring. Lower-extremity move need to be considered. Furthermore, extreme caution
ments, such as hip and knee flexion, may help to posi needs to be observed in positioning these patients and
tion the diaphragm for improved excursion. Lower-ex moving their limbs because they are at risk of sublux
tremity movements will also increase venous return, ations, pressure sores, bruising, and strains.
which may or may not be desirable, depending on the Interventions to promote mucociliary transport and
patient. The goals of upper- or lower-extremity work secretion clearance are applicable to all situations in
must therefore be clearly defined. Possible benefits which secretions, mucosal edema, bronchospasm, or a
and untoward effects must be identified to ensure the combination of these factors occur. If postural drainage
patient benefits optimally from the prescribed exercise. is indicated to further facilitate mucociliary transport
The treatment of choice in all patients is to stimu and secretion clearance, caution needs to be exercised
late those conditions that maintain optimal oxygen to avoid inducing bronchospasm and hypoxemia; thus
transport in health or approximate those conditions as the use of percussion should be considered carefully.
closely as possible. That is, the most physiological
interventions are exploited first and the least physio
PATIENT WITH RESTRICTIVE LUNG DISEASE
logical interventions are exploited last or when more
physiological interventions are not possible. Physio
Pathophysiology and medical management
logical interventions such as mobilization may be The initial priority of management in the acute phase
contraindicated in patients whose oxygen delivery is of myocardial infarction (MI) is the correction of the
too low. Without some reserve capacity in oxygen immediate problems including dysrhythmias, my
transport, the patient cannot sustain the additional ocardial insufficiency, reduced cardiac output, hy
metabolical load that mobilization imposes. Patients poxemia, chest pain, and anxiety followed by imple
who are this critical are often put on neuromuscular mentation of a progressive rehabilitation program
blocking agents to reduce muscle tone and thereby ranging from the acute medically stable phase to post
reduce oxygen demand. Because these patients are in discharge rehabilitation phase (Andreoli, Fowkes,
induced paralytic states, mobilization is not possible. Zipes, and Wallace, 1991; Froelicher, 1987; Irwin
2. Low-intensity activity until medical stability has been maintained and patient shows signs of physical improvement.
3. Progressive mobilization begun in conj unction with patient's medical status, ECG stability, and unchanging or re
solving enzyme levels.
4. Reduce patient's anxiety about his or her condition, self-care activities, and family and work responsibilities.
5. Gentle mobilization exercises, deep breathing, and coughing are usually begun immediately as a prophylactic
measure, although crepitations are frequently audible in the bases of the lungs of coronary patients; treatments
need to minimize pulmonary congestion and cardiac stress.
6. Relaxation is often promoted with low-intensity activity. All levels of activity, including breathing exercises, are
ped'ormed in a coordinated, rhythmic manner. Breath holding. Valsalva maneuvers, and isometric muscle contrac
tions, (i.e., isometric exercise and exercise involving significant muscle or postural stabilization) are absolutely
contraindicated during all activities in patients with coronary artery disease and should not be performed in any
stage of a rehabilitation program.
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32 Intensive Care Unit Management of Primary Cardiopulmonary Dysfunction 593
and Tecklin, 1985). Before admission to the coronary cluding generalized or localized pain anywhere over
care unit, continuous monitoring of the heart rate and the thorax, upper limbs, and neck, palpitations, dysp
rhythm is established. An intravenous line is rou nea, lightheadedness, syncope, sensation of indiges
tinely started for the administration of medications tion, hiccups, and nausea.
and fluids. An arterial line may be started for serial Depending on the degree of myocardial infarction
blood sampling for blood gases and enzyme mea and damage, varying lengths of modified mobility
sures. Initially, pain medications, coronary vasodila may be recommended (Andreoli, Fowkes, Zipes, and
tors, and diuretics are frequently used to minimize the Wallace, 1991). During this period, the physical ther
work of the heart, anginal pain, and discomfort. apist concentrates on rhythmic breathing exercises,
Drugs such as morphine serve to depress the respira gentle coughing exercises or huffing, modified posi
tory drive; thus the physical therapist must be aware tioning with the bedhead elevated at least 15 degrees
of corresponding changes in vital signs. Less potent to facilitate the gravity-dependent mechanical action
sedatives and tranquilizers are more routinely pre of the heart and thereby reduce myocardial oxygen
scribed. Increascd pain and anxiety potentially demand. The patient is encouraged to perform deep
worsen the patient's cardiac status by increasing my breathing and coughing every hour during the day.
ocardial oxygen demand and altering normal breath Bed exercises including rhythmic, unresisted, hip and
ing pattern and gas exchange. knee and foot and ankle exercises are usually per
The primary purpose of oxygen administration to formed every 4 hours or so, or when the patient turns
the cardiac patient is to reduce hypoxemia, myocar in bed. The patient is cautioned to exercise one leg at
dial work, and angina. Dyspnea, however, is com a time, sliding one heel up and down the bed, guard
monly observed in the initial phases of myocardial ing against lifting the leg off the bed. These exer
infarction and can be effectively controlled by sup cises; when performed correctly and coordinated with
plemental oxygen administered by nasal cannulae or inspiration and expiration require relatively little ef
mask. Oxygen may also correct potential ventilation fort or additional physical stress to the MI patient.
perfusion mismatching and hypoxemia. Oxygen is Comparable with the management of the postopera
always administered with humidity to avoid drying tive patient, these exercises are performed prophylac
the airways. tically to reduce the risk of venous stasis and forma
Blood gas analysis is performed within an hour of tion of thromboemboli. In addition, they may help to
initiating oxygen therapy to establish a baseline of ar regulate more coordinated breathing, encouragc deep
terial saturation. In this way, oxygen dose can be al breaths and mucociliary transport, and rcduce atelec
tered to regulate blood gases and acid base balance. tasis. The patient is cautioned against performing the
VaJsalva maneuver and straining because these activ
ities increase intrathoracic pressure and reduce car
MEDICAL CARDIAC PATIENT
diac output.
Principles of physical therapy management
Electrocardiographic (ECG) monitoring of the car
A primary principle of the management of the patient diac patient is the responsibility of all members of the
after myocardial infarction is to reduce myocardial health-care team involved in the patient's care. The
oxygen demand and workload. The myocardium physical therapist has a special responsibility to be
needs rest to promote optimal healing. Judicious rest proficient in ECG interpretation in the coronary care
of the myocardium is a priority that can often be bal unit because physical therapy is one of the most
anced with gentle rhythmic, non static movements. metabolically demanding interventions for patients
The box on p. 592 illustrates several ways of reduc (Dean et aI., 1995; Weissman et aI., 1984). The phys
ing myocardial workload in patients with cardiopul ical therapist often has the responsibility of initiating
monary disease. new activities with the cardiac patient, which might
The physical therapist should be watchful at all include sitting over the edge of the bed, engaging in
times for signs of impending or silent infarction, in self-care (particularly involving the arms being main
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594 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
tained in a raised position), getting in and out of bed, duration, and frequency of these activities (Bjore,
sitting in a chair, going to the bathroom, walking 1972; Froelicher, 1987). The patient's tolerance and
around the room or in the hallways, and eventually changes in ECG and vital signs are used as indicators
exercising on the treadmill or ergometer. Changes in for establishing and modifying the treatment program.
the ECG must be watched for, particularly when in These physiological parameters must be observed
troducing new activities and increasing the intensity carefully as the patient progresses to optimize the po
of workload in activities. Careful attention to ECG tential benefits of the therapeutic regimens as early as
changes and serum enzyme levels will contribute to possible without endangering the patient.
enhanced physical therapy care of the acute MI pa Patient education and prevention of infarction are
tient by optimizing the treatments prescribed and the particularly important for the cardiac patient. As
margin of safety with which activities are performed. soon as the patient is alert and able to cooperate, in
Congestive heart failure may be unavoidable in formation about his or her condition with guidelines
cases of severe infarction or even milder infarction about activity, diet, and stress management is rein
coupled with lung disease. Fluid intake and output forced. The more involved and informed the patient
and daily weight measurements promote early detec
tion of congestive heart fai lure. Routine fluid intake
by an intravenous line should not exceed 20 to 30 ml
per hour. Signs of imminent and established conges
tive heart failure appear in the box below. The work
of the heart can be significantly reduced in the up
right position (Levine and Lown, 1952).
All cardiac patients are prone to anxiety about their
conditions and prognoses. The patient is given realis
tic guidelines at each stage of recovery with respect to
the level of activity that can be safely performed,
which can potentially avert deterioration and promote
recovery. Involving the patient in rehabilitation plan
ning from the onset facilitates the patient's planning
realistically for the future and may help to reduce the
depression often experienced by the acute MI patient.
The initial rehabilitation program is planned with
the long-range rehabilitation goals in mind. The pro
gram designed for the cardiac patient is progressive in
terms of types of activities, usually beginning with ac
tivities of daily living and with respect to the intensity,
Development of tachydysrhythmias
Development of dyspnea
Patient following open heart surgery (4 hours
Development of increased jugular venous pressure postoperative). NOTE: patient on mechanical ventilator,
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32 Intensive Care Unit Management of Primary Cardiopulmonary Dysfunction 595
Stage I
Patient may be seen in the postanesthesia and recovery room for a physical therapy assessment; the patient is usually
extubated within 24 hours after surgery. Although the patient must be permilled to rest as much as possible in the
initial 24-hour period, judicious body positioning is instituted to stimulate physiologic "stir-up." Usually once ex
tubated, the patient is positioned side to side for deep breathing and coughing at least four times in the first 24
hours and low-intensity mobilization is initiated. Medications are administered before lreatment to ensure optimal
effect during treatment. Depending on the findings of x-ray, physical examination, and arterial blood gases, the pa
tient may require vibrations and possibly percussion. Postural drainage positions are modi lied to avoid tipping the
patient head-down and causing increased myocardial strain. A sputum sample for culture and sensitivity testing
may be taken at this time. The patient can usually tolerate being dangled over the edge of the bed for a few min
utes. Special care is taken for all hem1 patients to avoid the Valsalva maneuver, forced coughing, and huffing and ,
to maintain a semirccumbent or upright position for treatment. Blood pressure is checked before, during, and after
treatment. Mobilization is progressed.
Stage 2
Deep breathing and coughing maneuvers coupled with mobilization are continued. Positioning for enhanced alveolar
ventilation and ventilation and pelfusion matching may be indicated. If secretion accumulation is a problem and
the patient too unstable to be optimally mobilized or positioned, postural drainage and possibly percussion and/or
vibration may be indicated. Upper limb and neck exercises are introduced. Neck exercises are withheld if central
venous pressure lines are still in place in the neck veins. The patient can sit in a chair at bedside as tolerated. The
patient is encouraged to stand erect for a minute or so on transferring back and forth to the chair.
Stage 3
The patient can take ShOl1 walks as tolerated. Ambulation is not begun until arterial lines and the Swan-Ganz catheter
have been capped or removed. Vital signs are monitored before and after standing and walking. Deep breathing
and coughing maneuvers are continued even if the chest is clear, until the patient is up and about within reasonable
limits as tolerated. The patient is encouraged in grooming and self-care.
Stage 4
Deep breathing and coughing should be done by the patient without supervision. The presence of atelectasis on x-ray
or from assessment findings. however, would indicate the need for continuation of mobilization and body position
ing with breathing exercises. Ambulation is increased as tolerated.
Stage 5
Palient can participate in individual or class activities, concentrating on trunk mobility, upper-extremity range of mo
tion, coordinated breathing activities, posture. biomechanics, and increasing the patient's endurance gradually.
Stage 6
The palient can attempt six to eight stairs if progress has been satisfactory and as indicated. Aortic repairs in the first
week or so are prone to rupture. Elevation of the blood pressure is therefore avoided to reduce the risk of break
down of the aortic suture line.
Stage 7
The patient depends primarily on ambulation for maintaining optimal alveolar ventilation and mucociliary transport
rather than brealhing and coughing exercises. The patient is cautioned to balance a period of exertion with a period
of rest. The pat ient may be discharged. The physical therapi st ensures the patient fully understands the specific de
tails of the home exe rci se progrdm. The emphasis of exercise for cardiac patients conlinues to be
- 011 rhythmic, co
ordinated dynamic movements on discharge, avoiding isomelric, static exercise. If possible, the patient is invited to
participate in a reconditioning and health promotion program as an oUlpatient in a physical therapy department.
NOTE: The physical therapist must guard againsl excessively intense treatmenl of open heart surgical palienLs or other patients who are on a
prophylactic course of anticoagulants.
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596 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
is in self-management, the greater the likelihood of cate different practices, depending on their facilities,
receptivity and adherence to a rehabilitation regimen experience of the surgical and ICU team, and the in
after discharge. cidence of postoperative complications and survival
for that institution.
The physical therapist must guard against exces
PATIENT AFTER OPEN HEART SURGERY
sively intense treatment of open heart surgical pa
Principles of physical therapy management
tients or other patients for whom periods of relatively
Patients scheduled for open heart surgery are treated restricted mobility (4 to 5 days) are anticipated. Tn ad
as high-risk surgical candidates because of the nature dition to the fact these patients may be hemodynami
and invasiveness of this type of surgery (Figure cally unstable initially, these patients may be suscep
32-3), regardless of their general level of health be t i b l e to s o f t t i s s u e bruising f r o m being on a
fore surgery (Trekova, Dementyeva, Dzemeshke prophylactic course of anticoagulants.
vich, and Asmangulyan, 1994). Whenever possible, Physical therapy follow-up should continue sev
patients prepare for surgery in advance by decreasing eral months beyond discharge at which point the pa
or stopping smoking, by avoiding exposure to respi tient should be well integrated into a cardiac rehabili
ratory tract infections, by avoiding stress, by eating a tation program. Continuity and continuation of
balanced diet, and by getting adequate sleep. In addi physical therapy throughout the entire rehabilitation
tion, patients can benefit from a modified, prescrip period, from acute- to long-term, cannot be overem
tive exercise program before surgery to maximize phasized given that achieving a maximal recovery
their aerobic capacity and thereby improve their peri from surgery is the priority.
operative course.
In the preoperative period the physical therapist
SUMMARY
may spend additional time with patients scheduled
for open heart surgery to provide teaching of the This chapter describes the principles of cardiopul
basic anatomy and physiology related to surgery to be monary physical therapy in the management of criti
performed, the effect of anesthesia, the role of intuba cally ill patients with primary cardiopulmonary dys
tion and mechanical ventilation, the incision lines to function. Cardiopulmonary failure secondary to
be expected over the chest and the legs if veins are to chronic lung disease and heart disease are described.
be removed for bypass surgery, the lines, leads, chest Cardiopulmonary physical therapy management is
tubes, and catheters that will be in place after surgery, based on the specific underlying pathophysiological
and the course of recovery the patient might expect mechanisms of these various disorders. Tbese princi
barring complications (Chapter 26). The emphasis on ples, however, cannot be interpreted to be guidelines
patient education in most open heart surgery units for specific treatment in that each patient is an indi
may contribute to the generally low incidence of vidual whose condition reflects mUltiple factors con
complications and mortality. tributing to impaired cardiopulmonary function or
Some guidelines for physical therapy management threatening it (i.e., the effects of restricted mobility,
of the open heart surgical patient appear in the box on recumbency, extrinsic factors related to the patient's
p. 595. These guidelines are to be applied thought care, and intrinsic factors related to the patient in ad
fully and cautiously with regard to each specific pa dition to the underlying pathophysiology).
tient's condition and observed recovery. These guide
lines suggest the upper limit of intensity of physical
REVIEW QUESTIONS
therapy if all is progressing well initially and sh0uld
be reduced if warranted by the patient's condition. 1. With respect to critically ill patients with the fol
Progression from one stage to the next is based on an lowing conditions, describe the pathophysiology
optimal and reliable treatment response at each level of primary cardiopulmonary dysfunction, car
before proceeding. Different institutions may advo diopulmonary failure, obstructive lung disease,
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32 Intensive Care Unit Management of Primary Cardiopulmonary Dysfunction 597
status asthmaticus, restrictive lung disease, and Dean, E. (1994). Physiotherapy skills: Positioning and mobiliza
coronary artery disease. tion of the patient. In B.A. Webber & lA. Pryor. (Eds.). Pfly.l'
iotherapv for respiratory and cardiac problems. E dinburg h:
2. Relate cardiopulmonary physical therapy treatment
Churchill Livingstone.
interventions to the underlying pathophysiology of Dean, E., Murphy, S., Parrent, L., & Rousseau, M. (1995). Meta
each of the above conditions in the critically ill pa bolic consequences of physical therapy in critically-ill p atients.
tient and provide the rationale for your choice. Proceedings of the world confederation of physical therapy
congress, Washington, De.
Dean, E., & Ross, J. (1992a). Discordance be tween cardiopuitnonary
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Copyrighted Material
Intensive Care Unit Management
of Secondary Cardiopulmonary
Dysfunction
Elizabeth Dean
INTRODUCTION
management are not mutually exclusive for each cat
This chapter describes the principles and practice of egory. Rather, considerable overlap may exist when
cardiopulmonary physical therapy in the manage conditions coexist. The principles presented are not
ment of secondary cardiopulmonary dysfunction that treatment prescriptions. Each patient must be as
can lead to cardiopulmonary failure. Some common sessed and treated individually taking into considera
categories of conditions described include neuro tion the contribution of immobility, recumbency, ex
muscular disease, morbid obesity, musculoskeletal trinsic factors related to the patient's care, and
trauma, head injury, spinal cord injury, and burns. intrinsic factors related to the individual patient (see
Each category of condition is presented in two parts. Chapter 16), in addition to the underlying pathophys
First, the related pathophysiology and pertinent as iology. For examples of specific treatment prescrip
pects of the medical management of the condition tions refer to the companion volume to this book en
are presented. Second, the principles of physical titled Clinical case studies in cardiopulmonary
therapy management are discussed. Guidelines to physical therapy.
599
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600 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
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33 Intensive Care Unit Management of Secondary Cardiopulmonary Dysfunction 601
potential for desaturation. falling Pao2 levels and dys sential that these attempts are maximized (i.e., the
rhythmias. the patient's hemodynamic status must be patient optimally rested and medicated le.g., bron
monitored closely during gravitational challenges. chodilators, analgesia, reduced sedation and nar
The importance of chest waH mobility to optimize cotics] is physically positioned to optimize length
three-dimensional chest wall excursion in chronic tension relationship of the diaphragm and abdominal
neurological patients is emphasized in Chapters 2 I muscles, positioned vertically to optimize inspiratory
and 22. This goal is particularly challenging in the lung volumes. and expiratory flows and avoid of as
neurological patient with acute respiratory insuffi piration, and is provided thoracic and abdominal
ciency. The goal is to promote alveolar ventilation, support during expiration to maximize intrathoracic
reduce areas of atelectasis. and optimize ventilation and intraabdominal pressures) (see Chapter 21).
and perfusion matching and breathing efficiency to These supportive measures will ensure that the bene
augment and minimize reliance on respiratory sup fits of the normal physiological cough mechanism,
port (i.e., supplemental oxygen and mechanical venti which is the single best secretion clearance tech
lation) while minimizing respiratory distress. This is nique, is maximized (i.e., the most productive cough
especially important because patients with neuromus with the least energy expenditure) (Bennett, Foster,
cular conditions are poor candidates for being and Chapman, 1990; Hasani et aI., 1991; Kirilloff,
weaned off mechanical ventilation (Petty, 1982). In Owens, Rogers, and Mazzocco. 1985; Zinman,
addition these patient are prone to microaspirations. 1984). Forced chest wall compression or forced ex
Promotion of mucociliary transport is therefore es piratory maneuvers are contraindicated (Nunn, Cole
sential to facilitate clearing of aspirate and minimize man, Sachithanandan, Bergman, and Laws, 1965).
bacterial colonization and risk of infection. Impaired mobility, inability to cough effectively,
Another major problem for patients with restric decreased airway diameter, and bronchospasm con
tive lung disease secondary to generalized weakness tribute to impaired mucociliary transport and secre
and neuromuscular disease is an ineffective cough. tion accumulation. In addition, impaired glottic clo
Cough facilitation techniques (e.g., body positioning, sure and increased risk of reflux in this patient
abdominal counter pressure, and tracheal tickle can population exposes the airway to risk of aspiration.
be used to increase intraabdominal and intrathoracic Prophylactically, multiple body positions and fre
pressures and cough effectiveness. A natural cough, quent position changes will minimize the risk of se
even when facilitated, is preferable and more effec cretion accumulation and stasis. If mechanically
tive in dislodging mucus from the sixth or seventh ventilated. these patients are suctioned as indicated.
generation of bronchi than repeated suctioning. Even If pulmonary secretions become a significant prob
a weak, facilitated cough may be effective in dis lem despite these preventative measures, postural
lodging secretions to the central airways for removal drainage positions are selected to achieve the opti
by suctioning or for redistributing peripheral secre mal effect (i.e., secretion mobilization and optimal
tions (Hasani, Pavia, Agnew. and Clarke, 1991). gas exchange). Given the treatment response. man
Huffing, a modified cough peJformed with the glottis ual techniques of which manual vibration would
open and with abdominal support. may help to mobi have the greatest physiological justification, may
Jize secretions in patients with generalized weakness yield some benefit.
(Hietpas, Roth, and Jensen. 1979). In some cases, Patients with chronic neuromuscular dysfunction
suctioning may be the only means of eliciting a and residual musculoskeletal deformity pose an ad
cough and clearing secretions simultaneously. ditional challenge to the cardiopulmonary physical
Coughing attempts are usually exhausting for these therapist in that cardiopulmonary function is less
patients. Thus ample rest periods must be inter predictable because of altered lung mechanics
spersed during treatment, particularly for the venti (Bake, Dempsey, and Grimby, 1976) and possibly
lated patient. Coughing maneuvers need to be strate cardiac dynamics. Thus clinical decision making is
gically planned. Even though the patient may be more experiential in these patients who require
only to effect a series of a few weak coughs, it is es close monitoring.
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602 PART Vl Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
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33 Intensiye Care Unit Management of Secondary Cardiopulmonary Dysfunction 603
in addition to the weight of internal fat deposits in are taught comparable with those described for the
and around the cardiopulmonary unit, can compro patient with neuromuscular disease. Body positioning
mise cardiac output and contribute to dysrhythmias. to facilitate coughing and supported coughing need to
Thus during all body position changes the patient be instituted to maximize cough effectiveness. These
should be monitored hemodynamically to ensure the maneuvers should be carried out in conjunction with
position is being tolerated well. Obese patients often hourly extreme position shifts.
slump after being positioned in the upright position. Morbidly obese patients have a high incidence of
It is crucial that the position of these patients is upper airway obstruction and sleep apnea secondary
checked frequently and corrected. The slumped posi to floppy compliant pharyngeal tissue. Thus the qual
tion can be counterproductive in that the benefits of ity of their sleep and rest is suboptimal, and they are
the upright position are significantly reduced and can apt to desaturate significantly while sleeping. These
lead to deterioration. patients are also at high risk for esophageal reflux
Although obese patients do not tolerate the prone and aspiration. The optimal resting position is with
position well, the semi-prone position can be benefi the head of bed up.
cial by simulating the benefits of the upright lean-for
ward position on the displacement of the abdominal
PATIENT WITH MUSCULOSKELETAL TRAUMA
viscera (Ross and Dean, 1992). This position also
Pathophysiology and medical management
simulates the prone abdomen-free position, which is
associated with even greater benefit than the prone Crush and penetrating injuries of the chest are com
abdomen-restricted position (Dean, 1985). The bene monly seen in the ICU (Moylan, 1988). Damage to
fits of the prone position for the obese individual in the chest wall, lung parenchyma, and heart contribute
clude increased lung compliance and enhanced gas to the risk of cardiopulmonary failure (see box on
exchange and oxygenation. The full prone abdomen p. 604). Associated injuries of the head, spinal cord,
restricted position is contraindicated in the obese in and abdomen may also contribute. Fractures of long
dividual with cardiopulmonary failure, however, be bones and pelvis are associated with fat emboli,
cause this position can compromise diaphragmatic which pose the threat of pulmonary embolism. In ad
descent and contribute to further cardiopulmonary dition, fluid loss in multiple trauma contributes to
distress and failure and possibly cardiac arrest. loss of blood volume, hypovolemia, and hcmody
Mucociliary transport is slowed and ineffective in namic instability. The more extensive the injuries, the
obese patients with cardiopulmonary failure. Fre greater the pain and need for analgesia. Pain con
quent body positioning will facilitate mucociliary tributes significantly to reduced alveolar ventilation,
transport and lymphatic drainage. The postural airway closure, and inefficient breathing patterns.
drainage positions can be effective in mobilizing se Paradoxical motion of the chest wall associated
cretions should accumulation become a problem. with flail chest and rib fractures results from instabil
Manual techniques are not likely to add much benefit ity of portions of the rib cage after trauma to the
particularly in the morbidly obese patient. Suctioning chest. If severe, patients may require surgical stabi
is essential to clear pulmonary secretions from the lization of the ribs or stabilization by continuous ven
central airways. tilatory management. Chest wall injuries and rib frac
The obese individual is at risk for postextubation tures are particularly painful.
atelectasis. Thus aggressive mobilization and numer The presence of blood or air in the chest cavity
ous positions and frequent position changes need to and in the potential spaces of the pericardiai sac and
be continued. intrapleural cavity impairs cardiac distension and
The spontaneously breathing obese patient has a contraction, impairs venti lation, promotes retention
weak ineffective cough, which will be even less ef of secretions, interferes with effective clearance, and
fective after a period of intubation and mechanical impairs lymphatic drainage (Marini and Wheeler,
ventilation. Deep breathing and coughing maneuvers 1989). Resolution of effusions can be facilitated with
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604 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
Inadequate Ventilation may restrict ventilation to the lung base and con
tribute to airway closure and basal atelectasis. Di
Reduced thoracic movement
aphragmatic injuries directly affect ventilation in two
Paradoxical thoracoabdominal movement
ways. First, the bellows action of the lungs is com
Tension Pneumothorax promised. Second, the lung is displaced by herniation
Cyanosis of the abdominal contents into the thoracic cavity.
Unilaterally absent breath sounds Analysis of blood gases in the patient with post
traumatic injuries of the chest often shows severe hy
Distended neck veins
poxemia and moderate elevations of arterial PC02.
Subcutaneous emphysema
The presence of acidemia is common, which may
Cardiac Tamponade have both respiratory and metabolical components.
Distended neck veins
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33 Intensive Care Unit Management of Secondary Cardiopulmonary Dysfunction 605
scutaneous electrical nerve stimulation and analgesia. ventilator. Small leaks can be tolerated and are usu
Optimizing alveolar ventilation and mucociliary trans ally compensated for by a n increase in tidal or
port and avoiding pulmonary complications are pri minute ventilation.
mary goals. Strapping the chest is avoided because this
further restricts and compromises chest wall expansion.
Multiple Trauma
The CUITent method of therapy for flail chest is in
ternal stabilization of the chest and use of a mechani The management of multiple trauma is a major chal
cal ventilator. Slight hyperventilation will usually re lenge for the rcu team. Multisystem involvement
duce the respiratory drive of most patients to allow and complications often present a precarious situation
the ventilator to take over the full work of breathing. in which priorities have to be defined for each indi
The flail segment is then stabilized by internal expan vidual situation. Multiple trauma can include head in
sion of the lungs. The treatment ensures adequate jury, chest wall injuries, fractures, lung contusions,
ventilation with the least pain possible. After 2 diaphragm injury, pleural space disorders, internal in
weeks, the flail segment is usually stable. juries, thromboemboli, fat emboli, and cardiac contu
When the patient can maintain a reasonable tidal sions. Shock and adult respiratory distress syndrome
volume and normal blood gases, weaning is begun. may ensue (see Chapter 34). The clinical picture of
As soon as tidal volume and forced vital capacity are the patient with mulliple trauma is compounded by
within acceptable limits, oxygen can be administered the mobilization and positioning restrictions imposed
through an endotracheal tube with a T tube assembly. (Ray et aI., 1974). Positive end-expiratory pressure
Arterial blood gases are monitored closely after the (PEEP) is frequently used to reduce the effects of
ventilator has been discontinued. Once the blood lung congestion secondary to shock or adult respira
gases are in acceptable ranges over a reasonable pe tory distress syndrome (ARDS) (McAslan and Cow
riod of time (i.e., 12 to 24 hours) the endotracheal ley, 1979). Arterial blood gases are assessed to evalu
tube is removed. ate the effectiveness of PEEP in effecting improved
oxygen transfer.
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606 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
to optimize oxygen transport. This is preferable to the trauma patient to reduce excessive oxygen con
mobilization exercises in the recumbent position. In sumption and promote comfort (Malamed, 1989).
some cases, traction can be transferred from over the Active relaxation refers to relaxing the patient
end of the bed to over a chair. A strict routine of body through participation of the patient in relaxation pro
positioning is maintained, although severe limitations cedures. Passive relaxation refers to relaxing the pa
often exist with respect to the specific positions and tient using passive procedures (e.g., body positioning,
the degree of turning permitted. Lower limb traction physical supports, talking slowly and calmly, and tak
can be maintained when the patient is positioned in a ing adequate time for conducting treatments). Taking
modified sidelying position. Coordinating treatments time to implement mobilization is essential. First,
with analgesia schedules reduces the patient's pain mechanically moving and having patients who have
and fatigue, thereby improving tolerance to and pro mUltiple injuries move requires a prolonged period of
longing the treatment. These patients usually tolerate time. In addition, however, the cardiovascular and
the head-down position well provided head injury cardiopulmonary systems of critically ill need time to
does not complicate the clinical picture. adapt to new positions physiologically and to control
The acute effects of mobilization that will benefit concommitant discomfort. Prolonged periods of time
the patient with musculoskeletal trauma include aug may be required to turn a patient, dangle him or her
mentation of ventilation, perfusion, ventilation and over the bed, or transfer him or her to chair with con
perfusion matching, and promotion of mucociliary tinuous monitoring. Every effort is made to maintain
transport and cough effectiveness. General mobiliza the patient's spirits, reduce stress, and encourage a
tion exercises and propriocepti ve neuromuscular fa positive attitude toward active participation early in
cilitation (PNF) can be used to promote a mobiliza the rehabilitation program that begins in the ICU.
tion stimulus. Cycle pedals can be attached to a chair Care must be taken to avoid undertreating or
or the end of the bed to provide a low-intensity exer overtreating trauma patients. A clear chest can
cise challenge for some patients. Maximal work out rapidly regress because of general immobility and
put can be achieved within the patient's capacity limitations to body positioning imposed by traction
using an interval training type schedule (i.e., schedule and pain. Treatments should always be coordinated
of work to rest periods). A mobilization program that with the patient's analgesics to optimize treatment re
promotes the long-term effects of exercise can be pre sponse and for the patient's comfort. Whenever pos
scribed that involves as many large muscle groups as sible, the patient should be equipped with slings and
possible in rhythmic, dynamic exercise. pulleys and weights at bedside and a monkey bar
Frequent deep breathing and coughing is continued overhead for bed mobility and upper-extremity exer
during and between treatments, depending on whether cise. In addition to their cardiopulmonary benefits,
the patient requires mechanical ventilation. Body posi PNF patterns are useful in preparation for slings and
tioning is carried out within the limits of the patient's pulleys. The use of PNF patterns for trauma and post
traction and casts. Impaired mucocil iary transport is operative patients can be well tolerated by these pa
treated with body positioning and frequent position tients. All activities are taught in conjunction with
changes. Secretion accumulation may require postural breathing control exercises and coordination with the
drainage. Modified positions may be indicated because respiratory cycle.
of the positioning restrictions imposed by the fractures,
traction, and fixation devices. If indicated manual tech
PATIENT WITH HEAD INJURY
n i q u e s may be c o u p l e d with postu ral drainage
Pathophysiology and medical management
(Mackenzie, Shin, Hadi, and Ilnle, 1980). Care must
be taken to ensure the addition of manual techniques is Hypoxemia is observed in many patients with injury
beneficial and is tolerated by the patient. to the central nervous system (Demling, 1980). This
Relaxation interventions, both active and passive, may reflect primary damage to the cardiopulmonary
should be integrated into the treatment regimen for centers of the brain or secondary effects of associated
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33 Intensive Care Unit Management of Secondary Cardiopulmonary Dysfunction 607
trauma. Arterial blood gases are therefore closely ICP depend on cerebral blood volume and intracranial
monitored in these patients. compliance. On cerebral stimulation, a chain reaction
Acute cerebral edema with sudden increase in in is initiated. Cerebral activity is increased, which in
tracranial pressure (ICP) and reduction in cerebral turn elevates metabolical rate, blood flow, and hence
pelfusion pressure, rapidly affects central control of volume and ICP. Alternatively, increased cerebral
respiration (Borozny, 1987). Advancing cerebral blood volume secondary to gravitational effects, in
edema is evidenced by deterioration in level of con creased ICP, and reduced cerebral perfusion pressure.
sciousness, pupillary reflexes, ocular reflexes, pattern The head of the bed is usually maintained between
of respiration, and exaggerated muscle tone and pos 30 and 40 degrees to promote venous drainage and
ture. The sequence of these clinical signs corresponds thereby reduce ICP. The patient's head and neck can be
to progressively increasing ICP from the cortex to fixed in a neutral position by halo traction or by sand
ward the medullopontine region. With involvement of bags positioned on either side (Figure 33-1). Mechani
the brain stem, respiration becomes variable and inco cal hyperventilation is used to maintain PC02 below
ordinate. With loss of central control and imminent normal limits but above 20 mm Hg. Arterial blood
cessation of breathing, respiration is shallow and gases are checked during or immediately after hyper
ataxic. The appearance of the jaw and laryngeal jerk ventilation. Prolonged hyperventilation is avoided.
with each inspiratory effort suggests a poor prognosis. Barbiturate coma may be induced to decrease the
Physical therapy and the patient's normal routine cerebral metabolical rate for oxygen and hence cere
may have a dramatic effect on the ICP. ICP can be el bral blood flow. The reduction in cerebral metaboli
evated indirectly by an increase in intrathoracic pres cal rate exceeds the reduction in blood flow and thus
sure as a result of physical therapy or suctioning. oxygen supply exceeds demand, which is a desirable
Turning and positioning may produce obstruction to treatment outcome. Invasive hemodynamic monitor
cerebral venous outflow. Noxious stimuli, such as ar ing is instituted in conjunction with barbiturate
terial and venous punctures or cleansing wounds, can coma because barbiturates contribute to hemody
elevate ICP and relatively innocuous stimuli, such as namic instability.
noise or pupil checks. Wbether these factors elevate A complication of head injuries is acute lung in
--
' ......... IIIft,-
.
' . . . .
FIGURE 33-1
Patient following neurosurgical procedure; head of bed elevated 20 degrees to help reduce ICP.
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608 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
jury, specifically, neurogenic pulmonary edema (see may be acceptable provided the pressure returns to
Chapter 34). Antonomical nervous system dysfunc normal immediately after the removal of the pres
tion contributes to hypertension and neurogenic pul sure-potentiating stimulus. Prolonged elevation of
monary edema. The endothelial tight junctions in the ICP suggests low cerebral compliance and the possi
pulmonary capillaries leak protein into the intersti bility of potential brain damage unless pressure is re
tium along with fluid. Constriction of the lymphatic duced. Thus all interventions must be performed
vessels may also contribute to fluid accumulation by guardedly with due consideration being given to cor
impeding the removal of lung water. Increased fluid responding changes in ICP. Typically, management
accumulation in the interstitium may progress to the of patients with central nervous system trauma in
alveoli contributing further to impaired gas exchange cludes judicious tracheal suctioning, a stringent turn
and reduced lung compliance. ing regimen, lung hyperinflation with the manual
breathing bag in the nonventilated patient, or deep
breathing with occasionally increased tidal volumes
Principles of physical therapy management
or sighs in the ventilated patients.
Physical therapy priorities in the management of the If the ICP is unstable and a risk of brain damage
patient with cardiopulmonary dysfunction secondary exists, physical therapy should follow sedation. Ide
to head injury appear in the box below. ally, treatments should be peIformed when the ICP is
In cases of abnormally elevated ICP, mechanical low and intracranial compliance is satisfactory. The
hyperventilation and maintenance of Pe02 around 25 head-down position is contraindicated. Noise and
mm Hg are effective measures to reduce cerebral noxious stimulation that increases rcp should be kept
edema by reducing blood flow. Intracranial pressure to a minimum.
may increase with treatment and in particular with If the ICP is elevated, all noxious stimuli should
turning or suctioning. An ICP of up to 30 mm Hg be removed. In severe conditions a decision may
3. Position the patient within the limits of fracture stabilization and elevated intracranial pressure to promote alveo
lar ventilation and ventilation and pert'usion matching
4. Position the patient to reduce pathological patterns of muscle synergy and thereby promote ventilation and re
duce oxygen consumption
7. Reduce atelectasis
10. Promote m ucocil i ary transport and reduce pooling of secretions. and risk of chest infection
II. Reduce the work of breathing and improve the efficiency of the muscles of respiration, particularl y if long-term
disability is a risk
12. Perform active, active-assisted, or passive movements as soon as possible to enhance cardiopulmonary function
and secondarily to preserve musculoskeletal and neuromuscular function and reduce the risk of thromboemboli
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33 Intensive Care Unit Management of Secondary Cardiopulmonary Dysfunction 609
have to be made by the team to limit or withdraw in sions, is cardiopulmonary complications. Lung vol
terventions that lead to an excessive ICP increase that umes are reduced with the exception of residual vol
does not remit instantly (e.g., physical therapy, posi ume that increases. Interestingly, vital capacity in
tioning, suctioning, or neurologic assessment). creases in the supine compared with the sitting
Movement of the limbs is performed gently and in a position in quadriplegic patients. However, this does
relaxed manner. Patients in a comatose state may expe not counter the negative effects of reduced functional
rience passive limb movement noxiously. Intracranial residual capacity (FRC) and increased airway closure
pressure may be elevated as a result. Passive move in this position and reduced flow rates.
ments, however, may have the added benefit of pro Spinal cord injuries above C3 result in loss of
moting improved tidal ventilation in the nonventilated phrenic nerve i n n e r vati on, necessitating a t ra
patient by providing afferent stimulation to the respira cheostomy and mechanical ventilation. The lower the
tory center via peripheral muscle and joint receptors. level of the spinal cord lesion, the lower the car
Severe head injury may produce flexor or extensor diopulmonary risk. All patients with spinal cord in
posturing. These synergies may be inhibited by ap juries are at risk for developing atelectasis and pneu
propriately positioning the patient. Judicious body monia. The coughing mechanics of quadriplegic
positioning, in turn, reduces oxygen consumption and patients are abnormal and contribute to ineffective air
the patient's overall energy requirements. way clearance (Estenne and Gorino, 1992). In addi
Neurophysiological facilitation of respiration has tion the quadriplegic patient is at risk for developing
been proposed as a treatment intervention to improve pulmonary emboli. Prophylactic low-dose heparin is
ventilation, coughing, and breathing pattern in the un used routinely unless the presence of pulmonary em
conscious patient (Bethune, 1975). Neurophysiologi boli is suspected and higher dosages are indicated.
cal facilitation techniques include cocontraction of Patients with suspected spinal cord injuries usually
the abdominal muscles, vertebral pressure, intercostal undergo immediate spinal fixation on admission. De
stretch, lifting the posterior basal areas of the lungs, pending on the level of injury detennined by clinical
and perioral stimulation. Although these techniques signs and x-rays, traction, and fixation may be local
are believed to stimulate reflex involuntary respira ized to the head and neck or spinal support and cast
tory movements, there is no evidence to support their ing may be required in the thoracic or lumbar regions.
efficacy in the management of the unconscious pa
tient. Comparable with conventional chest physical
Principles of physical therapy management
therapy procedures, reported benefits associated with
neurofacilitation cannot be discriminated from the Because of the need to maintain relative immobility
potent and direct physiological effects of increased in the acute stabilization period of suspected spinal
arousal, body positioning, and mobilization on oxy cord injury, therapeutic body positioning rather than
gen transport (Dean, 1994b). These latter effects have mobilization is a primary intervention for optimizing
been well documented. oxygen transport. Although modified body position
Although arousing the patient and increasing oxy ing can be achieved, the provision of optimal care
gen consumption occurs with cardiopulmonary physi under these restricted conditions is a singularly im
cal therapy, arousal and oxygen consumption are pOl'tant challenge to the physical therapist, particu
generally minimized to reduce hemodynamic and larly with respect to the management of adequate
metabolical demands in head-injured patients. oxygen transport while the patient is in the ICU. Pa
tients with high spinal cord lesions can be positioned
in all positions within the limits of the cervical trac
PATIENT WITH SPINAL CORD INJURY
tion device being used, barring head injury. Both
Pathophysiology and medical management
head and foot-tipped positions, however, are intro
The principal cause of death in the early stages of duced cautiously and with hemodynamic monitoring
acute spinal cord injury, particularly for the high le because both positions can have significant car
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610 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
diopulmonary and hemodynamic consequences sec respiratory muscles. In some centers, patients are
ondary to spinal nerve loss and hence sympathetic started in the weaning period on respiratory muscle
nerve loss to the peripheral blood vessels. Turning training. The physical therapist must be well versed
frames such as the Stryker frame facilitate turning and practiced in this procedure before using it in con
and tipping these hemodynamically labile patients in junction with weaning the quadriplegic patient off the
the supine and prone positions (Douglas, Rehder, ventilator. Because of the potential risk of inappropri
Beynen, Sessler, and Marsh, 1977). ate application and of danger to the patient, respira
Effective body positioning, despite the need in tory muscle training must be effected knowledgeably
some cases for extensive modification, may be suffi to optimize its benefits for each individual patient.
cient to optimize oxygen transport secondary to im
proved regional ventilation and perfusion to all lung
Respiratory Muscle Training
fields. In the spontaneously breathing patient, deep
breathing and coughing maneuvers need to be cou Respiratory muscle weakness and fatigue, two physio
pled with position changes to optimize mucociliary logically distinct entities, are probably much more
transport (Alverez, Peterson, and Lunsford, 1981; common in the ICU than appreciated. These states
Braun, Giovannoni, and O'Connor, 1984). Some pa need to be recognized and detected early because both
tients may not tolerate numerous positions and posi can cause respiratory muscle failure (Macklem and
tion changes and thus have impaired mucociliary Roussos, 1977). The distinction between the two con
transport. If secretion accumulation and stasis de ditions is that weakened muscles respond to resistive
velop, postural drainage can be instituted; however, muscle training, whereas fatigued muscles do not. Ex
tipping must be attempted very cautiously. Patients posing fatigued respiratory muscles to resistive loads
should be monitored closely during and after treat can accentuate respiratory failure. The indication for
ment. Because of their well-documented side effects respiratory muscle training, therefore, is weak rather
(Kirilloff et aI., 1985) and the hemodynamic lability than fatigued respiratory muscles. Rest is indicated for
of acute quadriplegic patients, percussion and vibra fatigued respiratory muscles. Whether the respiratory
tion are applied cautiously, should they be indicated, muscles are weak or fatigued must be established be
depending on the severity of any complicating frac fore prescribing respiratory muscle training.
ture-dislocation(s), the stability of fixation, the condi The combination of immobilization and cardiopul
tion of the lungs, the presence of chest wall injuries, monary involvement secondary to multiple trauma
and hemodynamic lability. may result in similar disuse atrophy and weakness of
The high-frequency oscillating ventilator may the diaphragm as observed in other skeletal muscles.
have some benefit in the management of mUltiple Respiratory muscle weakness and fatigue can be a
trauma patients with spinal injuries who require ven component of both obstructive and restrictive pat
tilation. The advantages of the high-frequency oscil terns of lung disease. Patients with spinal cord in
lating ventilator include improved spontaneous mu juries do not have the same advantage of performing
c o c i l i a r y clearance and r e d u c e d i n c i d e n c e of coordinated general body activity and relaxation ma
atelectasis (Gross and King, 1984). Weaning quadri neuvers to help reduce the work of breathing. This
plegic patients off the ventilator requires special skill contributes to a marked decrease in respiratory mus
because of the lost function of the respiratory mus cle strength and endurance resulting in reduced vital
cles. For these patients, weaning can be particularly capacity, rib cage mobility, and the ability to cough.
fatiguing, frightening, and frustrating. Patients are For these reasons, patients with paralysis and demon
weaned lying supine when they are alert and able to strated respiratory muscle weakness are particularly
cooperate. Short periods off the ventilator on the T well suited for respiratory muscle training. The quad
piece are used initially. Use of the accessory muscles riplegic patient has lost the function of the intercostal
of respiration and any other muscular reserves are en muscles which are important muscles of inspiration
couraged to compensate for the loss of function of the and are responsible for thoracic cage expansion. In
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33 Intensive Care Unit Management of Secondary Cardiopulmonary Dysfunction 611
addition, the absence of the abdominal muscles, fatiguing factors as eating a meal, talking, exposure to
which are the primary expiratory muscles, drastically heat and humidity, sitting upright, overcoming a respi
reduces the ability to cough effectively and to per ratory tract infection, and so on.
form a forced expiration. The diaphragm and the ac A candidate for respiratory muscle training is
cessory muscles of inspiration, namely the scaleni equipped with an individual resistive breathing pack
and sternocleidomastoid muscles, then become the age containing the valve, mouthpiece, noseclip, flow
quadriplegic patient's respiratory muscles. regulator, and a series of resistors that attach to the
These factors as well as the effects of heat, humid inspiratory side of the valve (Figure 33-2). It is es
ity, and the vertical position, all predispose the quad sential that flow rate is controlled in that patients can
riplegic individual to the development of respiratory negate the training effect of a set resistor by chang
muscle weakness and failure. The physical therapist ing flow rate.
can help avert the effects of respiratory muscle weak An initial pretraining assessment is performed to
ness with respiratory muscle training. determine the appropriate resistor with which to com
Respiratory muscle training with a regimen of pro mence training. The progression to the next level of
gressive resistive breathing has been demonstrated to resistance is based on specific criteria of endurance
improve the strength and endurance of respiratory on the current resistor. Once the resistor has been
muscles (Gross and King, 1980; Loveridge and Dubo, chosen, a typical training session includes the steps
1990; Pardy and Leith, 1984) and improve functional shown in the box on p. 612.
capacity in some patients (Reid and Warren, 1984). Maximum inspiratory mouth pressure and vital ca
Resistive breathing exercise is aimed at the prevention pacity can be measured routinely to monitor change
of respiratory failure by increasing the strength and in diaphragmatic function. The level of inspiratory
particularly endurance of the key muscle of inspira resistance and the duration for which the patient can
tion, the diaphragm. Because the diaphragm is skeletal use each resistor are indications of the endurance of
muscle, it can be reconditioned using a series of inspi the inspiratory muscles. Measurement of vital capac
ratory resistance maneuvers. A stronger, endurance ity and maximum inspiratory and expiratory mouth
trained diaphragm will not fatigue as quickly as an un pressures provide an index of the strength of the in
trained diaphragm when exposed to such potentially spiratory muscles.
FIGURE 33-2
Handheld resistive breathing training devices. Left, P-Flex; resistance level is altered by changing
settings on dial. Right, DHD device; resistance level is altered by inserting stopper with different
size orifice into inspiratory port.
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612 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
I. The patient is usua lly in the sitting or upright position for training initial l y unless sitting is not yet indicated
3. The mouth pi e ce is p l aced securel y in the individual's mouth and a l l ows him or her to select an indi v i dual rate and
pattem of breathing
4. The patient adjusts flow rate to that designated and maintains it with feedback from the flow regulator
6. The patient is instructed to stop the exercise by letting go of the valve if the resistance becomes too difticu lt or if
lightheadedness or dizziness occur
7. When the individual has adjusted to the resistance in the initial training position. an attempt can then be made to
train at the same load in other positions
8. The parameters of the respiratory muscle training is determined by thc patient" s baseline: specific paramcters of
the prescription include initial resistance, the flow rate, the number of repetitions, the number of sets. the fre
quency of sessions. and progression
Modified from Hornstein S: Ventilatol), muscle training. A clinical guide for physiotherapis/s, Unpublished manual of the Spinal Cord In
jury Unit, Shaughnessy Hospital, J 984, Vancouver. Be.
Celtain precautions must be observed with respira plicate the clinical picture further and seriously
tory muscle training. Each time a new resistance is threaten tissue oxygenation (Cahalane and Deming,
tried, the physical therapist should be with the patient. 1984; Cane, Shapiro, and Davison, 1990). Hemoglo
The patient selects his or her own rate and pattern of bin has a higher affinity for binding with carbon
breathing. The inspiratory rate is usually constant. monoxide than oxygen. A carboxyhemoglobin level
Too shallow breathing is inefficient, and too slow, greater than 20% denotes carbon monoxide poison
deep breathing may result in accumulation of carbon ing. Levels in excess of 50% may produce irre
dioxide. The patient is cautioned about avoiding hy versible neurological damage. The principal danger
perventilation. The physical therapist, or the patient of carbon monoxide poisoning is that arterial Paoz
when he or she is capable, should check the valving can be adequate and tissue oxygen tension inade
system on the respiratory muscle trainer before each quate. Administration of high levels of oxygen is an
training session to ensure it is functioning properly. initial priority to reduce the half-life of carbon
monoxide to 1 hour from several hours.
Depending on the severity and extent of the burns,
PATIENT WITH BURNS
treatment ranges from conservative medical interven
Pathophysiology and medical management
tions to multiple surgeries related to progressive de
Cardiopulmonary complications are common in pa bridement and skin grafting. Both second and third
tients with smoke inhalation with or without severe degree burns can result in severe disfigurement and
burns and are a major cause of death (Marini and disability. Second-dcgree burns are partial thickness
Wheeler, 1989). Smoke and chemical inhalation pro burns and tend to be painful. Third-degree burns are
duce edema, bronchospasm, cough, mucosal slough full thickness burns; these tend to be anesthetic in that
ing, hemorrhage, hoarseness, stridor, and profuse the nerves themselves have been destroyed. Body po
carbonaceous secretions. Irritation of the alveoli and sitioning to optimize oxygen transport is life-preserv
acute pulmonary edema can result in a condition re ing; however, positioning and limb splinting must also
sembling adult respiratory distress syndrome (see be considered from the outset to minimize defonnity
Chapter 34). Carbon monoxide poisoning may com and restore optimal neuromuscular and musculoskele
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33 Intensive Care Unit Management of Secondary Cardiopulmonary Dysfunction 613
siderable healing and has occurred. Fluid and impaired thermoregulation, hypermetabolism and in
imbalances have considerable implica creased energy expenditure, ileus and disten
tions for hemodynamics and cardiopulmonary func sion, pain, and infection. Eschar formation associated
tion 15) and contribute to with circumferential burns of the chest wall mechani
instability, which necessitates modification of the cally restricts chest wall movement and can lead to
physical management. respiratory failure. Tissue edema that can continue for
An may be inserted initially with burns to a few after the bum contributes to increased tis
the airway, and in anticipation of progres sue pressure and tissue potentiat
sive which would make the insertion of air tissue ischemia and necrosis. Late complications
way considerably more difficult hours or days later. include gastrointestinal bleeding to stress
Ventilatory assistance is indicated with evidence of ulceration and the continued high risk of infection.
to smoke inhala
and burns of the nose, throat, airway,
PrinCiples of physical therapy management
lungs, and chest wall. A nasotracheal tube i s pre
ferred to tracheostomy tube because complications physical therapy is often required
with a tracheostomy tube are greater in burn patients. immediately for the with inhalation to
Cardiopulmonary are re maintain the of the prevent atelecta
lated to or tluid overload in the initial stage. sis and retention of and improve or main
Acute pulmonary edema and are largely tain gas Pulmonary function may be se
preventable with careful fluid Central ve verely i r e d as t h e n e t result of i n halation
nous pressure can be in the burn patient burns and trauma to the chest wall, and
because of severe fluid loss and may remain at low tluid imbalance.
values pulmonary edema. artery physical often has to be
pressure more reflects the status of the modified in the burn 1984). Mobi
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614 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
lization to enhance oxygen transport is exploited as traindicated over freshly grafted skin; however, man
much as possible, however, because of blood volume ual vibration may be transmitted from a more distal
and hemodynamic problems, orthostatic intolerance site to a lung field that cannot be vibrated directly.
may limit mobilization and positioning alternatives. Risk of aspiration is increased if tube feedings are
With more severe burns and more extensive burn dis not discontinued for at least I hour before treatment.
tribution, body positioning is the primary interven A nasogastric tube is often used and should be cor
tion. Positioning to effect an optimal therapeutic ef rectly positioned particularly during treatment.
fect on oxygen transport is challenging because of the Stimulating exercise and gravitational stress may
significant physical limitations that may exist. Given initially consist of being in the upright position prefer
that body positioning profoundly influences ventila ably with the legs dependent, performing selected
tion and perfusion matching (Clauss, Scalabrini, Ray, limb movements and dangling over the edge of the
and Reed, 1968), the reduced number of positioning bed for a few minutes if this can be tolerated. how
alternatives will contribute to shunt, ventilation and ever, in patients with severe burns and significant
perfusion mismatch, and hypoxemia. This effect will fluid imbalance, active and active-assisted movements
be accentuated if the patient is mechanically venti in an upright position that can be tolerated, may sub
lated (see Chapter 32). stitute. As the patient's tolerance increases, free un
Patients who have skin grafts require particular supported sitting can progress to standing and walk
care when moving or positioning because of the dan ing. Ambulation during ventilator-assisted breathing
ger of sheering forces of the graft, which can disrupt should always be considered for any patient for whom
the circulation, nutrition, and healing of the new skin. this activity is not contraindicated. The upright posi
Sterile procedures must be observed at all times. The tion and physical activity in the upright position are
physical therapist is usually required to cap, gown, likely to enhance markedly the patient's cardiopul
mask, and glove before treating the patient with ex monary and neuromuscular function, and improve the
tensive exposed areas and to cover the chest with a patient's strength and endurance in preparation for
sterile drape. Facilitating mucociliary transport is a long-term rehabilitation. If sitting up and ambulation
priority if the patient has significant mobility and po are not imminent, appropriate limb movements,
sitioning restrictions because of the burn severity. preferably active, can help provide an exercise stimu
Wherever possible, mobilization in conjunction with lus that can enhance oxygen transport. Passive full
multiple body positions and position changes is at range of motion exercises, in addition, are required to
tempted to maximize mucociliary clearance (Wolff, maximize joint range (a distinct goal from that to en
Dolovich, Obminski, and Newhouse, 1977). If secre hance oxygen transport), wherever possible.
tions have accumulated, positioning for postural Positioning to minimize deformity is a priority
drainage requires the same consideration as position given the potential consequences for cardiopul
ing for improved alveolar ventilation and ventilation monary function and oxygen transport, as well as
and perfusion matching. In the spontaneously breath musculoskeletal and biomechanical reasons. Position
ing patient, postural drainage positions can be used ing a burn patient regardless of the goal should con
selectively to increase alveolar volume in the superior sider alignment, pressure points, muscle balance, and
lung fields and alveolar ventilation to inferior lung effect on healing and grafted skin.
fields, in addition to purposes of drainage of the su Certain precautions have to be observed in the
perior bronchopulmonary segments. However, if the management of the burn' patient. First, skin loss con
patient is mechanically ventilated, the superior lung tributes to substantial fluid loss, often resulting in la
fields are preferentially ventilated (see Chapter 32). bile fluid and electrolyte imbalance. This situation
Should the addition of manual techniques be indi enhances myocardial irritability and the risk of dys
cated, percussion may not be comfortably tolerated in rhythmia. Hemodynamic and ECG monitoring is per
the presence of first and second degree burns. Manual formed routinely during physical therapy treatment.
vibration may substitute. Manual techniques are con Second, large areas of skin loss increase the risk of
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33 Intensive Care Unit Management of Secondary Cardiopulmonary Dysfunction 615
neuromuscular morbid drome: twelve years' experience. Archives of Physi cal Medi
cine and Rehabilila/ion, 70, 180-185.
musculoskeletal trauma, head spinal cord
Dean, E, (1985). Effect of body position on pulmonary function.
injury, and burns.
Physical 65, 613-618.
2. Relate cardiopulmonary Dean, E. Cardiopulmonary development. In B.R. Bonder
ment interventions to the underlying &M.B. (Eds.). Philadelphia: FA Davis.
ology of each of the above conditions in the criti Dean, E. (l994b). Invited commentary on "Are incentive spirom
etry, intermittent positive pressure breathing, and deep
cally ill patient and the rationale for
breathing exercises effective in the prevention of postopera
your choice.
p ul m o n a r y c o m p l i c a t i o n s a f t e r u p p e r a b d o mi n a l
P .. p ,,,·I" A systematic overview and meta-analysis. Physical
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616 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
Douglas, W.W., Rehder, K., Beynen, F.M., Sessler, A.D., & Mackenzie, D.F. (Ed.). (1989). Chest physiolhempv in the in ten
Marsh, H.M. (1977). Improved oxygenation in patients with sil'e care Llni! (2nd ed.). Baltimore: Williams & Wilkins.
acute respiratory failure: The prone position. American Review Mackenzie, C.F., Shin, B., Hadi, F., & Imle, P.e. (1980). Changes
of Respi ralOl y Disease, 115(4),559-566. in total lung/thorax compliance following chest physiothernpy.
Dureuil, B., Viires, N., & Cantineau, J.P. (1986). Diaphragmatic A nesthesia & Analgesia, 59. 207-210.
contractility after upper abdominal surgl'l'y . Joumal ofl\pplied Macklem, P.T, & Roussos, e.S. (1977). Respiratory muscle fa
PhysioioRY. 61.1775-1780. tigue: A cause of respiratory failure? Cli nical Science & Mole
btenne. M . & Gorino, M. (1992). Action of the diaphragm during
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72. 1074-1080. (2nd ed.) St. Louis: Mosby.
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and airway patency. Respiratury Care, 24. 710. Surge/y, 109.537-541.
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Rellllbilitalion. Review of ReSI) i ralOr y Diseases, 129. 1 82-184.
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Complications, Adult Respiratory
Distress Syndrome, Shock, Sepsis,
and Multiorgan System Failure
Elizabeth Dean
INTRODUCTION
physiological deficits in these complex conditions is
The purpose of this chapter is to describe some com the basis for efficacious management in addition to re
mon complications seen in critically ill patients. Com ducing the risk of an untoward treatment response and
plications arising from the following conditions are preventing worsening the patient's condition.
included: respiratory failure, surgery, acute lung in
jury and adult respiratory distress syndrome, shock,
RESPIRATORY FAilURE
sepsis, and multiorgan system failure. Second, the im
plications for cardiopulmonary physical therapy are
Metabolical Dysfunction
presented. Complications add further complexity to
the diagnosis of the multiple factors contributing to The range of complications associated with respira
impaired oxygen transport and to the challenge of pre tory failure that can further impair tissue oxygenation
scribing effective treatment. Understanding the patho are described in the box on p. 619. The metabolical
617
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618 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
consequences of these complications and impairment (Fenwick, Dodek, Ronco, Phang, Wiggs, and Russell,
of oxygen transport are lifc threatening for the pa 1990). This so-called pathological dependence of
tient. Thus prevention of their development is a prior oxygen consumption on oxygen delivery occurs
ity. Should complications develop, however, early when the cells are inadequately extracting and using
detection and definitive management becomes the oxygen even in the presence of supranormal oxygen
priority if the patient is to survive. delivery levels. This phenomenon is observed in pa
A hallmark of these complications is the impair tient with adult respiratory distress syndrome and
ment of multiple steps in the oxygen transport path shock (discussed later this chapter).
way, which adds to the complexity of management Given physical therapy is one of the most meta
(Dantzker, 1991). The three major components of bolically demanding rcu interventions (Dean, Mur
oxygen transport can be affected individually or in phy, Parrent, and Rousseau, 1995; Weissman and
combination (i.e., oxygen delivery, consumption, and Kemper, 1993), the physical therapist needs to be
extraction) (Pallares and Evans, 1992; Wysocki, Bes able to calculate this safety margin to prescribe the
bes, Roupie, and Brun-Buisson, 1992). type of treatment and its parameters (i.e., intensity,
In health the ratio of oxygen consumption to deliv duration and frequency) such that treatment is maxi
ery is low (i.e., 23%, which ensures an over supply of mally beneficial and associated with the least risk to
oxygen as a safety margin) (see Chapter I). This the patient.
safety margin also ensures that most patients are able The ultimate treatment outcome measures are
to recover from insults to the oxygen transport sys markers of oxygen tissue metabolism (Dantzker,
tem. However, if the insult is extreme, such as that 1993; Nightingale, 1993; Pallares and Evans, 1992).
resulting from complications of respiratory failure, In addition, hourly assessment of oxygen delivery,
surgery, acute lung injury and adult respiratory dis consumption, and extraction provide the basis for di
tress syndrome, shock, sepsis, and multiorgan system recting management of oxygen transport deficits.
failure, significant metabolical dysfunction secondary
to tissue hypoxia can result (Guiterrez, 1991).
Pulmonary Dysfunction
The relationship between oxygen consumption
and delivery has elucidated our understanding of he Complications of the cardiopulmonary system can
modynamic and metabolical changes observed in lead to respiratory failure (see box on p. 619) (Boggs
critical illness (Vincent, 1991). The phenomenon of and Wooldridge-King, 1993; Civetta, Taylor, and
oxygen-delivery dependence of oxygen consumption Kirby, 1988). Some of these relate to being mechani
occllrs when a patient's oxygen transport system is cally ventilated. Certain technical problems related to
unable to supply sufficient oxygen to meet basal oxy the cuffs used in conjunction with artificial airways
gen demand (Phang and Russell, 1993). Oxygen de may occur (e.g., overinflation, distortion, and hernia
livery below 300 ml 02/min/M2 limits the oxygen tion of the orifice of the tube). Mucous plugs can oc
diffusion gradient and reduces oxygen extraction and clude the endotracheal tube or tracheostomy and im
utilization at the ceLlular level. This is termed the pede ventilation. The common complications can be
critical/evel of oxygen delivery. When oxygen deliv reduced if the tube is changed frequently and if mini
ery exceeds 300 ml/min/M2, oxygen consumption mal amounts of air are used for cuff inflation.
does not depend on delivery. Thus the greater the de Prolonged endotrach al intubation can result in la
livery in relation to consumption the greater the ryngeal edema, ulceration, and fibrosis. Mechanical
safety margin. When oxygen transport is so severely ventilation may also rupture a bleb on the surface of
compromised that oxygen delivery falls below the the lung and produce a pneumothorax with rapid ten
critical level, anaerobic metabolism is triggered. sion development. Chest tubes are inserted immedi
However, anaerobic metabolism may also be trig ately to relieve the tension. Blebs occur when alveoli
gered at levels of oxygen delivery that exceed the rupture, causing air to track to subpleural sites.
normal critical threshold for anaerobic metabolism Mechanical ventilators can be a source of infection.
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34 Complications, Adult Respiratory Distress Syndrome, Shock, Sepsis, and Multiorgan System Failure 619
Cardiac dysrhythmias and hemodyn,lmic instability tions and requires mobilization be carried out cau
tiously within the patient's hemodynamic tolerance.
Myocardial dysfunction
Metabolical dysfunction
T':L: physical therapist can help minimize this risk by Fluid retention can occur with prolonged mechanical
not directly handling the ventilator attachments that ventilation in a patient with no evidence of cardiac
communicate with the air flow channels. Condensation failure. Pulmonary edema, weight gain, decreased pul
from the hose should not be drained toward the venti monary compliance, and reduced oxygen transport are
lator or toward the patient. The physical therapist common signs. Fluid overload is a common cause of
should be maskcd and gloved when connecting and this fluid retention. Mechanically ventilated patients
disconnecting the patient to and from the ventilator. are therefore usually maintained underhydrated. Be
Oxygen toxicity is a significant clinical complica cause of a tendency for sodium retention and hence
tion of mechanical ventilation. Mechanical ventila fluid retention, intravenous saline solution is kept to a
tors have precise oxygen controls to deliver the low minimum. Humidifiers attached to mechanical venti
est possible inspired oxygen concentration needed to lators are responsible for adding a considerable
maintain arterial oxygen tensions. Because of the ia amount of water by absorption through the lungs.
trogenic complications of high FIo2 levels (i.e., deni
trogen atelectasis and oxygen toxicity) excess oxygen
Cardiac Dysrhythmias
above the patient's needs is never indicated other
than short periods of hyperoxygenation before suc Cardiac dysrhythmias are a common complication of
tioning or in preparation for, during, and immediately respiratory failure. In addition, patients in respiratory
after mobilization (Fell and Cheney, 1971; Shoe failure tend to be older adults who as a group have a
maker, 1984). greater incidnce of dysrhythmias secondary to cardiac
Flow-directed pulmonary artery catheters (i.e., disease. Electrocardiographic monitoring is therefore
Swan-Ganz catheters), commonly used in the inten essential for all patients requiring ventilatory assis
sive care unit (lCU) for monitoring patients who de tance in addition to patients with overt or suspected
velop hemodynamic complications, are also associ heart disease. Both atrial and ventricular tachydys
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620 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
rhythmias are seen in acute respiratory failure. Sinus over the lower legs to minimize venous pooling and
tachycardia and premature ventricular contractions, assist venous return (see Chapter 32). JOBST® and
however, are particularly common. With rapid lower TED® stockings also may be applied over the feet
ing of arterial Pe02, ventricular fibrillation, or even and legs to increase circulatory transit time in the de
death may occur. pendent areas and reduce circulatory stasis.
In the presence of respiratory failure and in the ab
sence of cardiac disease the management of cardiac
Myocardial Dysfunction
dysrhythmias lies predominantly in the correction of
blood-gas abnormalities. Effective supportive man As in any clinical situation, acute myocardial infarc
agement can usually be achieved with pharmaceutical tion can occur during the management of acute respi
agents. Intravenous injection of lidocaine followed by ratory failure. The risks are increased because pa
continuous infusion is useful in managing premature tients in respiratory failure tend to be older and more
ventricular contractions, which may be the precursor susceptible to positional hypoxemia. The probability
of potentially fatal tachydysrhythmias and cardiac ar of heart failure and associated dysrhythmias is in
rest. Electrolyte replacement may also be required. creased and significantly compounds the problems of
A thorough understanding of the clinical presenta the patient in respiratory failure.
tion, electrocardiographic diagnosis, and correct man
agement of cardiac dysrhythmias is fundamental to
Gastrointestinal Dysfunction
the optimization of physical therapy treatments in the
ICU and minimizing any risk to the patient. Cardiac Peptic ulcer is commonly associated with chronic
dysrhythmias resulting from any cause necessarily re airway obstruction. The stress of respiratory failure
quire ongoing evaluation and therapy. predisposes the patient to peptic ulceration. Pro
The physical therapist must be able to treat the found hemorrhage may occur and blood replace
patient optimally and safely within the restrictions of ment is necessitated.
any dysrhythmia in addition to other medical or sur Gastric dilation may occur in patients who are re
gical conditions. The implications of the dysrhyth ceiving mechanical ventilation. Gastric dilation is
mia on the patient's clinical presentation and for best managed by means of a nasogastric tube and in
treatment selection and response must be recognized termittent suction. Care must be exercised to avoid
by the physical therapist and considered in designing hypokalemia and hypochloremia caused by excessive
the treatment plan. gastric suctioning. Special care is also taken to avoid
fecal impaction, particularly in the paralyzed patient.
This risk can be reduced with suitable fluid balance,
Thromboembolism
mobilization, frequent turning in conjunction with ap
A high incidence of pulmonary thrombosis or em propriate trunk and lower limb movements.
bolism exists in patients in acute respiratory failure.
Early diagnosis and management of pulmonary
Neurological Dysfunction
thromboembolism have been greatly facilitated by the
use of serial ultrasound procedures and scans. Physi A close correlation exists between the state of con
cal therapy has a key role in preventing the develop sciousness and the arteri 1 P02 and Pe02. In addition,
ment of t hromboemboli by p r o moting f r equent changes occur in alertness, personality, memory, and
changes in position, specific bed exercises, particu orientation with altered blood gases. Motor changes
larly of the lower limbs, and passive range of motion also occur, including generalized or localized weak
exercises if indicated. It is essential that movement ness, tremors, twitching, myoclonic jerks, gross
and repositioning are performed regularly to maxi clonic movements, convulsions, and flaccidity. Neu
mize their cardiopulmonary protective benefits. Pneu rological complications of respiratory failure must be
matic extremity cuffs apply pressure intermittently differentiated from those of nonpulmonary origin.
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34 Complications, Adult Respiratory Distress Syndrome, Shock, Sepsis, and Multiorgan System Failure 621
The physical therapist must be aware of the spectrum teredo The presence or absence of cyanosis may be an
of neurological complications that can result from unreliable sign because peripheral cyanosis can occur
respiratory failure and recognize that apparent im despite adequate arterial P02. Morbidity and mortality
provement of neurological signs may reflect im has been reported to be reduced in patients with se
proved cardiopulmonary status. vere respiratory failure and system involvement when
Sllpranormal levels of oxygen delivery was achieved
(Hayes, Yau, Timmins, Hinds, and Watson, 1993;
Renal Dysfunction
Waxman and Shoemaker, 1980; Yu, Levy, Smith,
The development of renal failure greatly compro Takiguchi, Miyasaki, and Myers, 1993).
mises the chances of the patient's survival. Renal
failure can result from gastrointestinal bleeding, sep
sis associated with shock, drug-induced nephrotoxic
ity, and hypotension, Urinary outputs are maintained Common Postoperative Complications
with adequate fluid and diuretics, with care not to in
Hypoxemia
duce pulmonary edema. Dialysis may need to be in
stituted if more conservative management fails Hypercapnia
(Phipps, Long, and Woods, 1991). If dialysis is antic Increased work of breathing
ipated, the physical therapist should review existing Increased work of thc heart
treatment goals to mOdify treatment accordingly,
Fluid shifts and third spacing
Pneumonia
Hypoxemia
Thromboemboli
The most common postoperative complication is hy
Pulmonary embolus
poxemia secondary to alveolar hypoventilation, re
Coaglliopathies
duced functional residual capacity (FRC), airway clo
Sepsis
sure, and postsurgical atelectasis (Leblanc, Ruff, and
Milic-Emili, 1970; Marini, 1984; Ray et aI., 1974). Shock
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622 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
Smoking history
Lifestyle factors-nutlitional status. stress, work situation. family situation, psychosocial support system. and substance abuse
Obesity
Pregnancy
Perioperative recumbency
Type of surgery
Extent of physical manipulation and compression of lung parenchyma, phrenic nerves, diaphragm. and the heart
Duration of surgery
Use of an airway
Oxygen therapy
Neuromuscular blockade
Invasive monitoring equipment (e.g., Swan-Ganz catheter, Foley catheter, intracranial pressure monitor. central
venous line, arterial lines, intravenous lines, and intraaortic balloon counter pulsation pump)
Infection
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34 Comp,lic:�ti(ms, Adult Respiratory Distress Syndrome, Shock, Sepsis, and .....'''r<mn System Failure 623
Pain
these increase with the magnitude of the op
in addition to the effects of anesthesia, fre erative procedure and of anesthesia required
contributes to alveolar hypoventilation and and the premorbid risk factors. These abnor
atelectasis after abdominal or thoracic surgery. malities observed in the period are
Rapid, shallow, and monotonous breathing may be and alveolar
spontaneously adopted by the patient to avoid pain FRC, and residual vol
and minute ventilation is fa- decreased in
alveolar ventilation is compromised by the in Because of the
creased ratio of dead space to tidal volume. Further crease in FRC (30% o r m o r e), c o m p liance is
more, in the absence of breaths, coughs, and vv"",-,a,,,"u, and therefore the work of is in
atelectasis may develop in the underventilated creased, Hypoxemia secondary to transpulmonary
portions of the The ventilation-perfusion ratio shunting usually becomes maximal within 72 hours
is disturbed because blood flow to underventilated after surgery, and often is completely resolved with
physiological shunting conservative management within seven days. The
tends to although Peo2 will on the mode of 100% oxygen ad-
may be An abnormally Low oxygen flows and low amounts of
monary pressure is then needed to reinflate these at tend to be delivered via nasal cannulae.
electatic alveoli. flows can deliver higher amounts of
masks and masks with reservoir bags.
always be taken into account when arter
Pulmonary Embolism and Deep Vein Thrombosis
ial blood gases. The is selected to provide ade
embolism is a potentially life-threatening quate oxygenation with lowest oxygen concentra
complication. Pulmonary embolism usually results tion possible.
from a thrombus forming in the veins of the lower Based on the assessment, arterial blood
limbs, in the atrium, or in the ven gases, fluid and balance, hemodynamic
tricle. Patients may be at risk if have varicose status, and x-ray, a decision is made as to which
chronic heart failure or if are preg treatments on the hierarchy will opti
nant, or oral rr""tr"""nh mize oxygen transport and what will be
The patient with a pulmonary thromboembolism used for each treatment.
usually has a sudden onset of and mobilizing them wherever possible will
chest pain, and apparent Occasionally, maximize FRC and reduce closing volumes and
heart failure follows. are often elevated. hence enhance gas and What
heart strain may be evidenced on ECG. Right these even minimally
bundle branch P waves, and inverted T their lack of alertness which must be explained. If the
waves may be seen. No abnormality may be noted on patient is unable to to treatment because of
chest x-ray. for this can b e discussed at
Treatment consists of primary and cir rounds and other medications should be considered
culatory with oxygenation of pe so that the is able to .. nl",n'·r f'" more. Thus
ripheral tissues. Anticoagulants, such as are even extreme body positioning will achieve more fa
infused intravenously to minimize further formation vorable results and Geraghty
of thromboembolic substrates. (1973; Ray, and Reed, 1968; Oou-
Beynen, and 1977;
Piehl and Brown, 1976).
Principles of physical therapy management
Endoctracheal intubation and mechanical ventila
of lung volume, tion may be indicated if blood gases fail to
and gas uniformly occur after anesthesia with conservative management. The treatment
and tissue dissection. The extent and duration of ties for the ventilated patient before and during
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624 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
weaning are presented in Chapter 32. Special atten Rest is prescribed as judiciously as treatment inter
tion in the postoperative patient is given to the pul ventions to enable the patient to physiologically restore
monary complications associated with diminished between and within treatments. This is particularly im
ability to move spontaneously, surgical pain, restric portant for ICU patients who are hypermetabolical and
tions imposed by dressings and binders, diminished have increased oxygen demands. Particular care must
ability to cooperate, and to periodically hyperventi be observed in prescribing treatment threshold parame
late the lungs. ters for these patients. Suprathreshold states can be as
Facilitating mucociliary transport is a primary goal sociated with an inappropriate balance between oxy
in these patients. Impaired mucociliary transport can gen delivery and oxygen consumption such that the
be precipitated by alveolar hypoventilation, perhaps patient becomes compromised (e.g., hemodynamically
the most common cause of postoperative complica unstable, cardiopulmonary distress is precipitated, or
tions. Sufficient impairment can lead to mucous sta both). A greater volume of a mobilization stimulus,
sis, airway obstruction, atelectasis, and infection. however, may be delivered to these patients with an in
Multiple positions, including upright positions and termittent mobilization regimen than with a single pro
360-degree axial turns, and multiple position changes longed course of mobilization. Thus the benefits that
facilitates mucociliary transport. In the event of mu would be accrued would be correspondingly increased.
cous accumulation and difficulty in removing pul Prevention of thromboemboli is a major treatment
monary secretions, specific body positions are se objective and is best achieved with mobilization, body
lected to optimize postural drainage of the affected positioning, passive movements, and physical devices,
bronchopulmonary segments and to maximize alveo such as pneumatic cuff devices and stockings, to aug
lar volume and ventilation. The addition of manual ment low-dose anticoagulants in patients at risk. Pa
techniques can be detrimental in severely ill patients tients who develop pulmonary emboli are treated
(Mackenzie, 1989; Poelaert, Lannoy, Vogelaers, medically and physical therapy needs to be corre
Everaert, D ecruyenaere, Capiau, and Colar dyn, spondingly modified to minimize oxygen consump
1991), thus their use needs to be considered carefully. tion until the embolus resolves and the patient is in no
Suctioning may be most effective immediately be imminent danger.
fore and after position changes. The appropliate oxy
gen transport variables are monitored to assess treat
ACUTE LUNG INJURY ANI) ADULT RESPIRATORY
ment outcome and minimally to ensure the patient
DISTRESS SYNDROME
who may be unstable is not deteriorating. If the pa
tient begins to deteriorate, treatment is discontinued Acute lung injury results from damage to the alveolar
until the patient stabilizes. Why the patient deterio epithelium (Gattinoni et aI., 1994). The extent of the
rated is determined so that a decision can be made as damage reflects damage to the type I and type II alve
to whether treatment can be reintroduced, and if so, olar cells. Damage to the type I cells results in alveo
what modifications are indicated. lar edema, atelectasis, and loss of lung compliance
Pain management is integral to the management of secondary to loss of structuraJ integrity of the alveoli
the surgical patient. Noninvasive and nonphannacologi provided by the type I alveolar cells. Damage to the
cal pain control strategies need to be exploited for all type II cells also contributes to atelectasis and loss of
surgical patients to augment or reduce the need for po lung compliance, but the mechanism relates to im
tent analgesics especially narcotics. Chapter 28 de pairment of the production of surfactant and pul
scribed some physical therapy pain control strategies for monary fluid that covers the alveolar epithelium.
surgical patients that can be applied with modification to Pulmonary edema refers to the accumulation of
the patient with surgical complications. Of these, use of vascular fluid in the interstitial spaces and alveoli. In
electrotherapy modalities, such as transcutaneous elec acute lung injury the mechanism of pulmonary edema
trical nerve stimulation, may be limited in the ICU be involves increased water movement across the pul
cause of electrical interference with monitoring devices. monary endothelial cells and increased permeability
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34 Complications, Adult Re5ioirato:rv and Multiorgan System Failure 625
of the endothelium to protein. This type of pulmonary Acute lung injury is characterized as a clinical spec
edema is referred to as noncardiogenic pulmonary trum of parenchymal cell dysfunction. Mild injury re
edema. Pulmonary edema that is in ori flects predominantly endothelial cell and
results from left ventricular failure. An increase noncardiogenic edema. Severe injury reflects a progres
in hydrostatic pressure damages the interstitial sion to both endothelial and cell dysfunction
spaces, which normally provide an effective barrier and adult respiratory distress syndrome The
between the pulmonary circulation and alveoli. The clinical spectrum of acute lung injury and the clinical
critical distinction between the two of pul manifestations of mild and severe are shown in
monary edema is that pulmonary edema 34-1. The clinical of moderate in
primarily involves the movement of water across the jury falls between these two extremes.
alveolar capillary membrane, whereas noncardio ARDS results from insult to the and in
pulmonary edema involves the movement of to the alveolar-capillary membrane. Some of the
and water into the interstitial and alveolar causes of ARDS include shock, severe trauma or in
spaces. The clinical consequences reflect the location fection, overwhelming and inhaled tox
of the edema alveolar or and ins. Increased vascular that
the amount of fluid accumulation. of the response is a common feature.
ENDOTHELIAL
CELLS
PERMEABILITY tt METABOLIC METABOLIC
INTERSTITIUM DYSFUNCTION 4+
DYSFUNCTION 1 +
EPTHELIAl CELLS
EDEMA EDEMA ttt EDEMA ttt
TYPE 1
TYPE 2
SLOUGHING ttt SLOUGHING tttt
HYPERMITOSIS METABOLIC
CONSOLIDATION tttt
FIGURE 34-1
manifestations the spectrum of acute injury from mild to
severe disease. (From Shapiro BA, Peruzzi WT: Changing inventilatator management: a
review of the literature and suggest clinical correlates, 117:121-133,1991.)
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626 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Cm'e
Fluid seeps into the interstitial spaces and over alveoli open and thereby optimizes gas transfer at
whelms the alveoli, leading to p u lmonary edema. end e xpiration. Arterial oxygenation is usually im
-
Lung compliance and gas exchange are severely proved with PEEP because the effect of shunting is
compromised. Thus the patient presents with severe reduced and a given Fl02 tends to be more effective.
dyspnea and hypoxemia. Diffuse pulmonary infil Although the Fl0 2 may be reduced, which reduces the
trates appear on x-ray. Arterial hypoxemia results pri possibility of oxygen toxicity, supranonnal oxygen
marily from underventilated but pelfused lung units delivery can be beneficial in these patients (Bishop et
and right to left shunt. In this situation, hypoxemia is aI., 1993). Survival may be improved and frequency
relatively refractory to increases in Fl0 . of multiorgan system failure reduced.
2
Fibrinogen in the fluids leaking into the alveoli Further monitoring of respiratory status in con
contributes to fibrosis and reduction of lung compli junction with arterial blood gases is essential for fol
ance associated with ARDS. Increased lung surface lowing the progress of the syndrome. In addition to
tension and alveolar collapse tend to result from an the oxygen transport variables the principal parame
inactivation of surfactant with the accumulation of ters monitored in ARDS are reduced lung compli
fluid in the alveolar spaces. Thus reduced lung com ance, tachypnea, and the concentration of inspired
pliance produces a significant decrease in FRC in the oxygen needed to maintain acceptable levels of the
patient with ARDS. arterial blood gases.
The signs and symptoms of ARDS may take up to ARDS is characterized by a major pathophysio
48 hours to be fully manifested. The prognosis for logical restrictive component. Hence the principles of
survival of patients is 40% to 60%. Hypoxemia is a management of restrictive lung disease can be effec
principal feature of the syndrome, and results from a tively applied. Changes in lung compliance and Fl0
2
right to left shunt, whereby fluid-filled alveoli are in requirements provide guidelines to treatment re
effectively ventilated. Hyperventilation and labored quired, treatment response, and course of the syn
respiration can be expected in conjunction with hy drome. Patients with ARDS require close monitoring
poxemia. Oxygen therapy has little effect in the pres and often frequent treatments aimed at promoting op
ence of shunting. Hypercapnia is not usually a major timal gas exchange because of the severity of the syn
problem in the ARDS patient. drome and high incidence of mortality associated
The metabolical perturbations that can result in with it. Special attention is given to body positioning
clude problems with oxygen delivery, consumption , to promote ventilation and perfusion matching and
and extraction as discussed previously. When oxy mucociliary transport and to minimize the effect of
gen delivery falls below the critical level, anaerobic restriction of diaphragmatic and chest wall excursion.
metabolism is triggered resulting in increased lactate Some patients, for example, benefit from side lying
production. Elevated serum lactates are associated in which excursion of the inferior hemidiaphragm is
with a poor prognosis. favored. Other patients, however, seem to detel;orate
from apparent restriction of the inferior lung in side
lying. Each patient's condition and specific areas of
Principles of physical therapy management
lung involvement must be taken into consideration
Intubation and ventilatory support are implemented if when prescribing a turning regimen. The effect of the
arterial blood gases are severely affected and rerspi patient's body position on blood gases helps to estab
ratory distress worsened. An endotracheal tube can lish a suitable regimen on a rational basis.
be placed t h r o u g h t h e n o s e o r mouth or a tra The sitting position optimizes lung capacity. The
cheostomy can be performed. The tidal volume is set use of a reclining chair at the bedside perhaps should
at about 10 mUkg of the patient's body weight. The be considered more often in the management of pa
patient usually establishes the respiratory rate, al tients with acute lung inj u ry. Theoretically, the poten
though it may be rapid. A positive end expiratory tial function of all lung fields will be benefited with
pressure (PEEP) of around 12 cm H20 maintains the the lungs in a more upright position. Patients who are
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34 Complications, Adult Respiratory Distress Syndrome, Shock, Sepsis, and Multiorgan System Failure 627
too unstable to tolerate upright positions may respond tribute to intracellular digestion and calcium deposi
favorably to extreme body positions and the prone tion. Once the lysosomes have ruptured and intracel
position (Albert, Leasa, Sanderson, Robertson, and lular digestion is triggered, irreversible cell damage
Hlastala, 1987; Langer, Mascheroni, Marcolin, and ensues, impairing oxygen extraction and uptake
Gattinoni, ] 988). (Wysocki, Besbes, Roupie, and Brun-Buisson, 1992).
Severely affected patients may require neuromus The pathology of shock and the effect on the res
cular blockade to reduce their oxygen demand and piratory membranes of the mitochondria follow a
enable them to respond to ventilatory assistance more similar course regardless of cause. Swelling of the in
effectively. Handling and positioning patients on neu terstitial tissue disrupts the perfusion of the pul
romuscular blockade requires particular care because monary capillaries. Congestive atelectasis and pul
these patients lack muscle tone to protect their mus monary edema ensue. In the advanced stages, hyaline
cles and joints. Rotating beds can be extremely bene membrane changes and pneumonitis may occur.
ficial for these patients who are either too hemody
namically unstable or difficult to turn manually.
Principles of physical therapy management
These mechanical beds slow ly rotate side to side
through an arc, thus changing the patient's body posi Foremost, the physical therapist must be knowledge
tion continuously (Gentilello et aI., 1988; Pape, able about the relationship of oxygen delivery and
Regel, Borgman, Sturm, and Tacherne, 1994). consumption in these patients, as well as the implica
tions of the pathophysiological processes on oxygen
extraction. The type of treatments and their pat'ame
SHOCK
ters are based on a careful analysis of oxygen trans
Common causes of shock include hypovolemia, sep port variables. Treatments are prescribed within the
ticemia, heart failure, and direct insult to the central patient's safety margin. Physical therapists in the
nervous system. Some of the classical features of ICU must also be knowledgeable about the signs and
shock are hypotension, reduced cardiac output, tachy symptoms associated with impending and frank
cardia, hyperventilation, diaphoresis, pallor, confu shock. By recognizing and understanding the compo
sion, nausea, and incontinence. Inadequate tissue per nents of the different types of shock and the effect on
fusion results in extracellular acidemia and loss of the cardiopulmonary system, the physical therapist
potassium ions from the cells. The pulmonary blood can better prescribe a rational treatment plan for the
vessels constrict in response to hypoxemia, which short- and long-term management of the patient.
tends to increase pulmonary artery pressures. Although physical therapy may be limited in re
Failure of cellular function secondary to shock can versing the signs and symptoms of shock, physical
result from a deficiency of substrate for energy pro therapy can help to restore and maintain optimal car
duction, a reduced ability to use the nutrients for en diopulmonary function, reduce the risk of complica
ergy production, or both. The pathophysiological tions associated with immobility and with recum
mechanisms responsible include hypoperfusion of the bency, and maintain physical status at the best
tissues, hormonal and metabolical cellular changes, possible optimal level during the episode and in an
and the toxic effects of the metabolical changes. Col ticipation of the patient's recovery. The primary ob
lectively, these produce cellular damage. With hy jective, however, is to minimize oxygen demand. A
poperfusion and decreased oxygen delivery and other minimal objective is not to worsen the patient's con
nutrients, the production of adenosine triphosphate is dition by imposing excessive metabolical demand.
reduced. The maintenance and repair of cell mem This is the case in patients whose oxygen delivery is
branes is disrupted, resulting in swelling of the endo approaching the critical level with respect to oxygen
plasmic reticular and eventually the mitochondria. consumption dependence. Excessive demands in
Persisting cellular hypoxia contributes to rupture of these patients can be life threatening.
the lysosomes, which releases enzymes that con Patients in shock are usually unresponsive. The
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628 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
course of the shock episode is often complicated with The fluid is drained after about 30 minutes. Car
the sequelae of immobility and recumbency. The spe diopulmonary physical therapy is most effective if
cific goals related to optimization of cardiopul performed after the fluid has been completely drained
monary and musculoskeletal function and prevention from the peritoneum. After drainage of the fluid the
of further complications associated with cardiopul diaphragm is at a more optimal functional length for
monary function in particular are priorities. respiration, which potentially can improve treatment
Specific concerns for the patient in shock include response. If hemodialysis is indicated, the patient is
the need for short, efficacious treatments and avoid connected to a unit that dialyzes the blood externally.
ance of unnecessary fatiguing of the patient. Treat This process takes several hours and is usually re
ment goals are therefore critically appraised and pri peated every few days.
oritized throughout each day to target physical In the end stages of shock, as for other severely ill
therapy treatment only to the very immediate and es medically unstable patients, physical therapy may
sential needs of the patients. Prudent patient position constitute primarily supportive care and comprehen
ing is a priority because of the relative immobility sive monitoring.
and reduced spontaneous movement observed in
these patients and recumbency. Approximations to
SEPSIS AND MULTIORGAN SYSTEM FAILURE
the upright position (i.e., head of bed up and foot of
bed down) can augment sympathetic stimulation and Sepsis is the response to bacteremia or other by prod
improve hemodynamic status and reduce sympath ucts of bacteria in the blood. The clinical features of
omimetic medications. In addition, this position sim sepsis include fever, tachycardia, tachypnea, and res
ulates the upright sitting position (although not per piratory alkalemia. Metabolical abnormalities are
fectly) with re spect to i t s beneficial effects on also a common feature of sepsis. Sepsis is the most
pulmonary and cardiac function. common predisposing factor contributing to multior
Late stages of refractory shock leading to renal gan system failure (MOSF), which typically involves
failure may necessitate dialysis. In peritoneal dialysis failure of more than two organ systems (Carrico,
a liter of fluid with a high osmotic fluid content is in Meakins, and Marshall, 1993; Vincent, \993). Table
jected into the patient's abdomen to draw fluid out. 34-1 shows the major organs affected and their clini-
TABLE 34-1
Modified from Civetta. J.M., Taylor, R.W., & Kirby, R.R. (1988). Critical care. Philadelphia: JB Li ppi ncott .
ARF. acute renal failure; SCOT. serum glutamic oxaloacetic transaminase; LDH. lactate, dehydrogenase; DIC, disseminaling intravascular
coagulalion; PT. prothrombin time; PIT. partial prothrombin time; C/, c ardiac index
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34 Complications, Adult Respiratory Distress Syndrome, Shock, Sepsis, and Multiorgan System Failure 629
cal manifestations (i.e., pulmonary, gastrointestinal, fective Floz. Even though the patient wi II likely bene
hepatic, renal, cardiovascular, hematological, and fit more from some positions than others, frequent
central nervous systems). The cascade of pathophysi body position changes, preferably 360-degree turning
ological features of this MOSF is believed to be pre regimen, are still necessary to avoid the sequelae of
cipitated by mUltiple mediator systems. The release static body positioning. Semi-prone positions can
of these mediators impairs oxygen delivery and uti substitute well for full prone positions if the patient is
lization of oxygen by the cells. Thus the supply of the too hemodynamically unstable. Semi-prone positions
major energy source to the cell, adenosine triphos may be tolerated better by the patient and may be
phate, is reduced which leads to structural and func safer. Even though hourly position changes may not
tional damage of the various organ systems. The mor be feasible in these severely ill patients, prolonged
tality rate ranges from 60% to 80%. periods in a static position (more than 2 hours) is
Conditions that predispose a patient to MOSF in deleterious to the patient. Thus a balance between
clude sepsis, overwhelming infection, multiple these two concerns must be achieved.
trauma and tissue injury, inflammation, and tissue Promoting optimal mucociJiary transport remains a
perfusion deficits. Patients who are older, have priority even in the absence of secretion accumula
chronic diseases, are immunosuppressed or have a se tion. Frequent position changes and numerous posi
vere initial presentation have an increased risk of fail tions ensure pulmonary secretions are continually
ure and mortality. being redistributed to prevent accumulation and en
hance removal. Should postural drainage be indicated,
these positions may need to be modified. Head-down
Principles of physical therapy management
positions in particular may not be tolerated well.
The patient with sepsis and MOSF, like the patient in Based on a careful assessment, the relative benefits of
shock, is gravely ill and unlikely to be able to cooper superimposing manual techniques must be established
ate with treatment. The principles for management in that these procedures are associated with increased
are comparable with those for managing the patient metabolical demand to which the patient is not readily
in shock, however, oxygen delivery is likely to be able to adapt. Increasing the oxygen demand of these
consistently compromised in these patients. If oxygen patients may worsen their condition.
delivery is critically low, oxygen consumption de
pends on oxygen delivery and the patient is in a state
SUMMARY
of metabolical acidosis (see Chapter I). In this situa
tion, where oxygen delivery is compromised to the This chapter presents several major complications
point of not meeting tissue oxygen demands, the goal that occur secondary to various conditions in the in
of treatment is to maximize oxygen delivery (Bishop tensive care unit. Complications add significantly to
et aI., 1993; Yu, Levy, Smith, Takiguchi, Miyasaki, the complexity of the physical therapy diagnoses of
and Myers, 1993) and minimize oxygen demand so the patient'S underlying problems with respect to
that oxygenation of vital organs is threatened to the oxygen transport and cardiopulmonary management.
least extent. Thus the physical therapist must estimate The complications highlighted in the chapter include
the oxygen reserve capacity (i.e., the balance between those that impair multiple steps in the oxygen trans
oxygen demand and oxygen) in every assessment to port pathway and hence jeopardize metabolism at the
select optimal treatment, which is associated with the cellular level. This sequence of events is most fre
least risk. Treatments are selected to improve the effi quently associated with the complications of respira
ciency of oxygen transport and utilization a n d tory failure, surgery, adult respiratory distress syn
thereby reduce the work of the heart and o f breathing. drome, shock, sepsis, and multiorgan system failure.
Above all, treatment should not worsen the patient's Physical therapy treatments in critical care areas
oxygen transport status. Selective body positioning are typically short, frequent, and should always be ef
can augment oxygen transport and maximize the ef ficacious. Patients with the complications, however,
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630 PART VI Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Intensive Care
stress the oxygen transport system minimally, thus organ failure syndrome, The gastrointestinal tract: the motor of
MOF. Archives of Surge/y, 121, 197-208.
are lower on the physiological treatment hierarchy).
Civetta, 1.M., Taylor, R,W., & Kirby, R.R. (1988), CrilicaL care.
These patients require frequent and comprehensive
Philadelphia: 18 Lippincott.
monitoring (often several times daily) of their oxygen Clauss, R.H., Scalabrini, BY. Ray, 1.F, III, & Reed, G.E. (1968).
transport capacity (i.e., the relationship between oxy Effects of changing body position upon improved ventilation
gen delivery and consumption, and oxygen extrac perfusion relationships. Circulatioll, 37(Suppl. 4), 214-217.
tion, to establish if and when treatment is indicated, Dean, E" Murphy, S., Parrent, L., & Rousseau, M. (1995), Meta
bolic consequences of physical therapy in critically-ill patients.
and the specific parameters of treatment. If a patient
Proceedings of the World Confederation of Physical Therapy
is thought to be too unstable for treatment at a given Cogress, Washington, De.
time, continued monitoring of her or his status is es Dantzker, D.R. (1991). Cardiopulmonary critical care (2nd ed.).
of body position changes so that these can yield the of Respirato/y Disease, 115, 559-566.
Fell, T, & Cheney, F W. (J 971), Prevention of hypoxia during en
greatest benefit to oxygen transport.
dotracheal suction. Annals of Surgery, 174, 24-28.
Fenwick, l,e., D odek, P.M., Ronco, 1.1., Phang, P.T" Wiggs, B" &
Russell, 1 , A. (1990), Increased concentrations of plasma lactate
REVIEW QUESTIONS
predict pathologic dependence of oxygen consumption on oxy
1. Describe the complications associated with respi gen delivery in patients with adult respiratory distress syn
drome, loumal of Crilical Care, 5, 81-86,
ratory failure.
Gattinoni, L., Bombino, M., Pelosi, P., Lissoni, A., Pensenti. A.,
2. Describe the implications for cardio ulmonary
Fumagalli, R., & Tagliabue, M, Lung structure and function in
physical therapy of respiratory failure, surgical different stages of severe adult respiratory distress syndrome,
complications, acute lung injury, adult respira loumal of the American MedicaL Association, 2 71 , 1772-1779,
tory distress syndrome, shock, sepsis, and multi Gentilello, L, Thompson, D.A., Tonnesen, A,S" Hernandez, D" Ka
padia, A,S., Allen, S.1., Houtchens, B.A., & Miner, M.E. (1988),
organ system failure.
Effect of a rotating bed on t he incidence of pu I monary complica
tions in critically ill patients. Crilica! Care Medicine, 16,783-786.
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34 Complications, Adult Respiratory Distress Syndrome, Shock, Sepsis, and Multiorgan System Failure 631
Mackenzie, e.F. (Ed.). (1989). Chest physiotherapy in the inlen Roukonen, E., Takala, 1., & Kari, A. (1991). Scrtic shock and mul
sive care IInil (2nd ed.). Baltimore: Williams & Wilkins. tiple organ failure. Cr itic al Care Medicine, 19,1/46-1151.
Marini, J.J. (1984). Postoperative ateleclasis: pathophysiology, Shapico, B .A., & Peruzzi, WT (1995). Changing practices in ven
clinical im porl an ce, and principles of management. Respiratory tilator management: A review of the literature and suggested
Care, 29, 516-528. clinical correlates, Surgery, 117, 121-133.
Nightingale, P. (1993). Optimization of oxygen transport to the tis Shoemaker, W,C, (Ed.). (1984), Critical care: state oj the art.
sues. Acta Anaesthesiologiea Scandinavica, 98, 32-36. Fullerton, CA: Society of Critical Care Medicine.
Pallares, L.e.M., & Evans, T.W. (1992). Oxygen transport in the Vincent, J.L. (1991). Advances in the concepts of intensive care,
critically ill. Respiratory Medicine, 86, 289-295. American Hearl J o urn al 121, J 859-1865.
,
Pape, H.e., Regel, G., Borgman, W., Sturm, J.A., & Tacherne, H. Vincent, J.L. (1993). Oxygen transport in severe sepsis. Ac l a
(1994). The effect of kinetic positioning on lung function and pul Anaesthesiolog), Scandinavica, 37 (Suppl 98), 29-3 J .
monary haemodynamics in posttraumatic ARDS: a clinical study. Waxman, K., & Shoemaker, W.e. (1980). Management of postop
Intemalional Journal ofth.e erative and posttraumatic respiratory failure in the intensive Care oJth
Petty, T.L. (1982). Ifllcnsive and rehabilitative respiratory care care unit. Surgical Clinics ofNorth America, 60, 1413-1428.
(3rd ed.). Philadelphia Lea & Febiger. Weissman, e., & Kemper, M, (1993). Stressing the critically ill pa
Ph an g, PT, & Russell, J.A. (1993). When does V02 depend on tient: the cardiopulmonary and metabolic resposnes to an acute
D02? Respiratory Care, 38, 618-630. increase in oxygen consumption. Journal of Critical Care, 8,
Phipps, W.J., Long, B.e., & Woods, N.F. (Eds.). (1991). Medical 100-108
surgical nurs ing : conce"ls and clinical practice (4th ed.). St. Wolff, R,K., Dolovich, M.B., Obminski, G., & Newhouse, MT
Louis: Mosby. (1977). Effects of exercise and eucapnic hyperventilation on
Piehl, M.A., & Bcown, R.S. (1976). Use of extreme position bronchial clearance in man, Journal oj Applied Physi olo gy 43,,
Copyrighted Material
PART VII
Copyrighted Material
The Neonatal and Pediatric Patient
Victoria A. Moerchen
Linda D. Crane
INTRODUCTION
(3) present principles and precautions of direct respi
Pediatrics entails a "special" application of cardiopul ratory care; and (4) incorporate these principles into
monary physical therapy. This chapter stresses that suggestions for practice.
cardiopulmonary development and its related vulner This chapter begins with a brief description of crit
abilities form the basis for cardiopulmonary practice ical events and important characteristics of cardiac
with neonatal and pediatric patients. and pulmonary development. Relevant diagnoses are
The objectives of this chapter include to: (l) re then presented to build onto this developmental per
view cardiopulmonary development and related vul spective and to stress that cardiopulmonary pathology
nerabilities; (2) relate developmental pathologies to and ventilatory compromise are often related to de
issues of adequate ventilation and oxygen transport; velopmental vulnerabilities. Finally, treatment ap
635
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636 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
proaches are described, including pediatric cardiac men ovale allows right-to-left blood flow through the
rehabilitation, pulmonary care for neonatal and pedi atria, bypassing the lungs (Yao, 19H3). Left ventricular
atric patients, pediatric pulmonary rehabilitation, and output (LVO) is well-oxygenated blood that then enters
developmental motor approaches for trunk and venti the ascending aorta and flows to the brain and upper
latory muscle function. body. The ductus arteJiosus similarly allows the lungs
A knowledge of cardiopulmonary development, to be bypassed, as most of the right ventricular output
congenital and d evelopmental cardiopulmonary (less well-oxygenated than the LVO) flows to the de
pathology, and pediatric cardiopulmonary treatment is scending aorta and from there to the lower body.
essential for any therapist serving children. Most pedi Fetal blood flow to the lungs is minimal, secondary
atric patients require ongoing attention to respiratory to high pulmonary vascular resistance during fetal cir
function, whether as a primary focus of physical ther culation. Only 10% to 12% of evo goes to the lungs
apy or as an inherent aspect of motor development. (Koff, 1993; Phelan, Olinsky, and Robertson, 1994),
This chapter is relevant to therapists who perform di with the function of nourishing the developing lung
rect cardiopulmonary care and to therapists who incor tissue rather than providing gas exchange.
porate a cardiopulmonary awareness into developmen
tal motor therapy.
Neonatal circulation
Adult-like circulation occurs at or shortly after birth,
with separation from the placenta and ventilation of
CARDIOPULMONARY DEVELOPMENT
the lungs resulting in closure of the ductus venosus,
The application of cardiopulmonary physical therapy foramen ovale, and ductus arteriosus. This process,
to infants and children requires a special understand referred to as transitional circulation, occurs early in
ing of developmental cardiopulmonary anatomy and neonatal life and increases the efficiency of oxygen
physiology. Knowledge of normal development and uptake and transport (Heyman and Hanley, 1994;
its inherent points of vulnerability will help the Rudolph, 1970).
reader understand some of what is known about car The initiation of breathing and the removal of lung
diopulmonary pathology in pediatric patients. fluid increases pulmonary blood flow. Whereas fetal
circulation was characterized by high pulmonary vas
cular resistance and low systemic resistance, separa
Cardiac Development
tion from the placenta causes a rise in systemic resis
Differences in fetal and neonatal gas exchange ac tance and a decrease in pulmonary vascular resistance.
count for differences in the anatomy and physiology As this shift in relative pulmonary and systemic resis
of fetal and neonatal circulation. A basic review of tances occurs, sites of intercommunication (shunts)
developmental circulation is essential for discussion close, and the ventricles shift from working in parallel
of congenital heart defects and the role of pediatric to working in series (Heyman and Hanley, 1994).
cardiopulmonary physical therapy. Closure of Foramen Ovale. The increased left atrial
pressure that occurs during transitional circulation re
Fetal circulation sults in apposition of the valve of foramen ovale
Placental oxygenation is a major characteristic of against the interatrial septum, functionally closing this
fetal circulation. Additionally, in fetal circulation site of fetal circulatory shunting (Rudolph, 1970). In
blood flow through the right and left sides of the most infants, anatomical closure occurs 2 to 3 months
heart occurs in parallel, such that cardiac output is ac later (Emmanouilides and Baylen, 1988; Yao, 1983).
tually combined ventricular output (eVO) (Heyman Closure of Ductus Arterioslls. Functional closure or
and Hanley, 1994). This is possible as a result of constriction of the ductus arteriosus occurs postnatally
shunts in fetal circulation (Parks, 1988). within the first IS to 72 hours in response to increased
Two points of shunting during fetal circulation are at arterial oxygen saturation (Daniels, Hopman, Stoelinger,
the foramen ovale and the ductus arteriosus. The fora Busch, and Peer, 1982). Anatomical closure of ductus
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35 The Neonatal and Pediatric Patient 637
arteriosus occurs by 2 to 3 weeks in most term neonates diaphragm of a newborn has fewer type I (high oxida
(Rudolph, 1970). It is important to note that the respon tive) muscle fibers (25% compared with 50% in adult)
siveness of the ductal smooth muscle to arterial oxygen (Muller and Bryan, 1979). This difference predisposes
tension and to endogenous prostaglandins is impacted an infant to earlier diaphragmatic fatigue when stressed.
by gestational age (Pack, 1988; Yao, 1983). A biomechanical difference between the infant
and child is the circular and horizontal alignment of
the ribs and the concomitant horizontal angle at
Pulmonary Development
which the diaphragm inserts on the ribs during new
Structural and functional characteristics of pulmonary born and early infant chest development (Massery,
development in infants and children are significant 1991; Muller and Bryan, 1979). This, along with the
because they may contribute to aspects of respiratory more cartilaginous nature of the rib cage, results in
vulnerability (Muller and Bryan, 1979). less efficient chest wall mechanics. The result, again,
is increased work to breathe. (See Chapter 37 for a
Newborn respiration
more complete discllssion of chest development).
The pulmonary anatomy of t h e term i n f a n t i s
Respiration in the child
markedly different from the adult but also different
from the child. An infant's airways are narrower from Two residual strllctural differences exist beyond the
the nares to the terminal bronchioles. This presents a newborn period and have potential implications for
point of pulmonary vulnerability because a smaller pulmonary vulne rabili ty in the child. First, the some
diameter airway is more easily obstrllcted by mucus, what horizontal angulation of the ribs persists unti I
edema, foreign objects, and enlarged lymphatic tis approximately 7 years of age and results in less effi
sue. The infant also has a high larynx (Laitman and cient chest wall mechanics (Muller and Bryan, 1979).
Crelin, 1980). Although this position of the larynx Secondly, lymphatic tissue (especially adenoids)
enables the newborn to breathe and swallow simulta grows rapidly until about 6 years of age (Sinclair,
neously, it may also contribute to predominant pat 1978) and can continue to be a potential source of
terns of infant nasal breathing, which can result in in upper airway obstruction.
creased work to breathe during any compromise of As infants and children grow and develop, how
the nasal airway. ever, most structural and functional disadvantages
Even without airway compromise, the work of disappear. An aspect of growth and development that
breathing is increased during the neonatal period. can be protective for infants and younger ch i ld re n is
The initial low compliance of the newborn's lungs alveolar multiplication. This begins in the rirst year
requires increased effort for ventilation, which re of lire and continues until approximately 8 years of
sults in a high rate of respiration and increased oxy age (Blackburn, 1992; Thurlbeck, 1975).
gen consumption.
Although the process of transitional circulation al
Cardiopulmonary Considerations
lows more efficient O2 transport in the neonate than
in the Preterm Infant
in the fetus, gas exchange in the newborn is still
somewhat inefficient because of immature alveolar All of the cardiopulmonary structural and functional·
structure and function. The surface area for gas ex characteristics of neonates that have been previously
change is 1120 that of an adult (Johnson, Moore, and discussed apply to the premature infant. Additionally,
Jefferies, 1980), and the diffusion distance across the there arc signi["jeant gestationa l characteristics and as
alveoli-capillary membrane is increa sed as a result of pects or cardiopulmonary vulnerability that are more
thick alveolar walls (Blackburn, 1992). pronounced and create more problems in premature
Functional characteristics of infant pulmonary de infants Cfable 35- I).
velopment are also significant to understanding possi Recall that the transitional circulation of a term
ble contributions to pulmonary distress in infants. The newborn includes a decrease in pulmonary vascular
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638 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
TABLE 35-1
ANATOMICAL PHYSIOLOGICAL
Capillary beds not well developed before 26 weeks' gestation Increased pulmonary vascular resistance leading
10 right-to-Ieft shunting
Type II alveolar cells and surfactant production not mature Decreased lung compliance
until 35 weeks' gestation; elastic properties of lung not
well developed; lung space decreased by relative size of
the heart and abdominal distention
Type I, high-oxidative fibers compose only 10% to 20% of Diaphragmatic fatigue: respiratory failure
diaphragm muscle
Highly vascular subependymal germinal matrix not resorbed Decreased or absent cough and gag reflexes; apnea
until 35 weeks' gestation, increasing the vulnerability of the
infant to hemorrhage
Lack of fatty insulation and high surface area to body-weight ratio Hypothermia and increased oxygen consumption
*Modified from Crane, L.D. (J 995). Physical Therapy for the Neonate with Respiratory Disease. In S. Irwin & lS. TeckJin (Eds.).
Cardiopulmonary physica/therapy. St. Louis, Mosby.
resistance over the first day. In preterm infants, how Most significantly, the immature status of car
ever, lung immaturity and abnormal surfactant func diopulmonary anatomy in preterm infants predisposes
tion (Jobe, 1988) may result in retained high pul them to h ypoxia under any conditions that require in
m o na r y resistance (p o o r lung complia nce), creased oxygen (Blackburn, 1992). Cardiopulmonary
hypoperfusion, and respiratory distress syndrome pathophysiology and/or the stressors inherent to med
(Walther, Benders, and Leighton, 1992). Persistent ical care often present challenges beyond the adaptive
pulmonary hypertension will reinforce persistent capacities of these fragile little systems.
right-to-Ieft shunting through the ductus arteriosus
(Nude! and Gootman, 1983; Rudolph, 1980). In fact,
COMMON PEDIATRIC DIAGNOSES
respiratory distress syndrome (RDS) has been identi
fied as the best predictor of prolonged patency of duc The sections that follow present and discuss specific
tus arteriosus (Milne, Sung, Fok, and Crozier, 1989). cardiac and pulmonary diagnoses. Common neuro
As the respiratory distress of the premature infant muscular or developmental diagnoses that have in
improves with neonatal intensive care, cardiopulmonary herent to them the risk of compromised respiration or
vulnerabilities can then occur in the opposite circulatory associated cardiopulmonary disease are also dis
direction. Given the gestationally related responsiveness cussed. The diagnoses presented are not all inclusive
of ductus arteriosus to oxygen, some preterm infants re but merely represent an attempt to give the reader a
tain patency of the ductus even when pulmonary vascu preliminary knowledge of underlying pathologies and
lar resistance falls (Archer, 1993). The result is Ieft-to medical management of diagnoses commonly en
right shunting that may lead to congestive heart failure countered in the practice of pediatric cardiopul
(Nudel and Grootman, 1983; Parks, 1988). monary physical therapy.
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3S The Neonatal and Pediatric Patient 639
TABLE 35-2
Cardiac Diagnoses
the most common heart defect during the neonatal
Patent ductus arteriosus, endocardial cushion defects, period (Musewe and Olley, 1992). In term newborns,
and tetralogy of Fallot are the cardiac defects dis however, PDA accounts for 10% of congenital heart
cussed within the limits of this chapter. Additionally, disease (Mitchell, Korones, and Berendes, 197 I).
Table 35-2 provides a summary of common develop Gestational age, the presence of lung disease, the
mental diagnoses and their associated cardiac defects. size of the ductus, and the direction of the shunt me
d i a t e the clini c a l f e a t u r e s of P D A (Gr e e n e ,
Patent ductus arteriosus
Mavroudis, and Backer, 1994; Musewe and O lley,
Patent ductus arteriosus (PDA), already introduced as 1992). The preterm infant with very low birth-weight
a cardiopulmonary complication in preterm infants, is will have the most extreme clinical picture. An infant
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640 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Thempy: Special Cases
or child with a large ductus will also have an obvious of mitral valve regurgitation (Merrill et ai., 1994).
clinical presentation. Tachycardia, an ejection sys For infants with complete ECD, early surgical repairs
tolic murmur, bounding peripheral pulses, increased are indicated (Bender, Hammon, Hubbard, Muirhead,
respiratory distress, and poor feeding or poor weight and Graham, 1982; Graham and Bender, 1980).
gain are the classical signs of PDA (Archer, 1993;
Tetralogy of Fallot
Greene et ai., 1994; Musewe and Olley, 1992). In the
term infant, PDA may be more clinically silent, espe Tetralogy of Fallot (TOF) is named for its "tetrad" of
cially when the ductus is small (Parks, 1988). defects: ventricular septal defects, right ventricular
Medical management of PDA includes nonsurgi outflow obstruction, right ventricular hypertrophy,
cal use of indomethacin or direct surgical closure of and aortic override (Bove and Lupinetti, 1994; Pin
the PDA (Musewe and Olley, 1992). sky and Arciniegas, 1990). A neonate with TOF will
have symptoms dependent on the extent of right ven
Endocardial cushion defects and
tricular tract obstruction, which results in decreased
artrioventricular defects
pulmonary blood flow and the presence of right-to
Endocardial cushion defects (ECD) represent a spec left shunting (Bove and Luppinetti, 1994). The clas
trum of defects characterized by malformation of the sic picture is one of cyanosis, especially with crying
atrial septum, the mitral and tricuspid valves, and/or (EmmanouiIides and Baylen, 1988; Pinsky and
the ventricular septum (Emmanouilides and Baylen, Arciniegas, 1990).
1988). Combinations of these defects are categorized In neonates, initial medical management may in
as complete, transitionaVintermediate, and partial, de clude treatment of hypoxemia by pharmacologically
pending on degree of ventricular septal deficiency maintaining patency or reopening the ductus arterio
(Merrill, Hoff, and Bender, 1994; Spicer, 1984). In sus for additional pulmonary blood flow (Driscoll,
the complete fOlm of ECD, all of the structures are 1990; Freedom and Benson, 1992). The elimination of
deficient. In the partial form, only an atrial septal de conditions that produce hypoxemia may also include
f e c t w i t h a cleft mit ral valve is present ( E m pharmacological agents to increase systemic vascular
manouilides and Baylen, 1988; Merrill e t ai., 1994; resistance and decrease myocardial contractility (Bove
Parks, 1988). and Lupinetti, 1994). Surgical repairs are generally
T h e r e is marked variation in the underlying performed within the first year (Bove and Lupinetti,
anatomy of this class of cardiac defects, such that 1994; Starnes, Luciani, Latter, and Griffin, 1994).
clinical features are equally varied and difficult to in
clusively summarize. In neonates with a complete de
Pulmonary Diagnoses
fect, heart failure may manifest in infancy. However,
neonates with milder forms of this defect may not be The section that follows provides a brief discussion
symptomatic until much later in development (Parks, of common pulmonary disorders for which chest
1988). Additionally, endocardial cushion defects are physical therapy is indicated. Additional physical
frequently associated with other cardiac defects (Em therapy treatment is described later in this chapter.
manouilides and Baylen, 1988).
Hyaline membrane disease
Although the total incidence of endocardial cush
ion defects in infancy is 1 % to 4%, the incidence in The most common respiratory disorder in premature
infants and children with Down syndrome is 40% infants is hyaline membrane disease (HMD) or infant
(Freedom and Smallhorn, 1992). In fact, in these chil respiratory distress syndrome (IRDS or RDS). Occur
dren a complete ECD is the most common cardiac ring almost exclusively in preterm infants younger
malformation (Spicer, 1984). than 37 weeks' gestation, HMD results from lung im
Operative management of infants and children maturity and an inadequate amount and regeneration
with ECD depends on the morphology of the defect, of surfactant (Phelan et ai., 1994). Surfactant func
the degree of pulmonary hypertension, and the extent tions to decrease alveolar surface tension and thus en
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35 The Neonatal and Pediatric Patient 641
abies the neonate to stabilize terminal air spaces (Wal with severe BPD (Berman, Katz, Yabek, Dillon,
lis and Harvey, 1979). Surfactant deficiency results in Fripp, and Papile, 1986; Gerhardt, Hehre, Feller, Re
alveolar collapse and increased effort to breathe. infenberg, and Bancalari, 1987). Right-sided heart
Clinical signs of respiratory distress resulting from failure (cor pulmonale) is a common sequelae of this
HMO occur early (usually within I to 2 hours) and disease, especially in the first few years. Addition
persist for at least 48 to 72 hours (Farrell and Avery, ally, BPD survivors demonstrate an increased inci
1975). Respiratory failure is 'common in these infants, dence of neurodevelopmental sequelae, including
necessitating oxygen therapy and assisted ventilation. cerebral palsy and general development delay (North
Chest physical therapy (CPT) is commonly indi way, 1979; Vohr, Bell, and Oh, 1982).
cated in the management of infants with HMO. There Chest physical therapy is an important component
is usually a marked increase in airway secretions in of the management of an infant with BPD. Airway
the "recovery" state of the syndrome (after approxi clearance problems are common due to submucosal
mately 2 to 3 days), which is exacerbated by oxygen and peribronchial smooth muscle hyperplasia, in
therapy and endotracheal intubation (Crane, 1981; creased mucous secretions, oxygen therapy, and fre
Finer and Boyd, 1978). quent lower respiratory tract infections. Infants with
BPD also frequently have poor growth, which may be
Bronchopulmonary dysplaSia
a consequence of a higher resting V02, such that
As more preterm newborns survive neonatal respira caloric needs are greater (Weinstein and Oh, 1981).
tory distress, the prevalence of chronic lung disease
Transient tachypnea of the newborn
or bronchopulmonary dysplasia (BPD) has increased
(Parker, Lindstrom, and Cotton, 1992). Although Transient tachypnea (TTNB) is another neonatal
controversial, the etiology of BPD is usually linked problem considered in the differential diagnosis of
with positive pressure ventilation and oxygen therapy HMD/RDS. It is associated with delayed clearance of
in the treatment of respiratory distress during the amniotic fluid from the lungs, results in early presen
neonatal period. The risk of BPD is highest in tation of respiratory distress, and is most common in
younger, low-birth-weight premature infants (Abman full-term and postterm neonates (especially if deliv
and Groothius, 1994). ered by cesarean) (Avery, Garewood, and Brumley,
Northway, Rosan, and Porter's (1967) classic de 1966; Emmanouilides and Baylen, 1988). Chest
scription of BPD includes four pathological stages. physical therapy is occasionally indicated for infants
The f irst stage invo lves s ymptoms si milar t o with this problem, but TINB is uSllally self-limited.
HMD/RDS, but b y the fourth stage, BPD has pro
Meconium aspiration syndrome
gressed to include characteristics of chronic lung dis
ease (Voyles, 1981). Meconium is the content of fetal and newborn bow
Clinically, infants with BPD often present with els. Although the cause of meconium passage is
rales, wheezing, cyanosis, hypoxemia, increased inci highly debated (Bacsik, 1977), once meconium is
dence of lower respiratory tract infections, and abnor present in the uterine environment the risk for aspira
mal chest radiographs by I month postnatally tion is significant. It is generally accepted that meco
(Abman and Groothius, 1994). Medical management nium aspiration most frequently occurs with the first
of BPD is primarily supportive. Long-term oxygen postnatal breaths of term or postterm infants (Gre
therapy is often necessary for infants who exhibit gory, 1977), but it may also occur with gasping in
persistent severe hypoxemia. utero just before delivery (Katz and Bowes, 1992;
The cardiopulmonary outcome of BPD is variable, Wiswell and Bent, 1993). Research has supported tile
ranging from near normal pulmonary function by age contention that meconium aspiration syndrome
3 to 5 in children who had milder forms of BPD, to (MAS) is often preventable if the upper and lower
continued poor cardiopulmonary function, chronic a i r w a ys a r e s u c t i o n e d immedi atel y after b i r t h
distress, and ongoing oxygen dependence in children (Wiswell, Tuggle, and Turner, 1990). The lower air
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642 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
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35 The Neonatal and Pediatric Patient 643
may benefit from CPT especially when they are re breathing (ACB) technique, use of a positive expira
sponding slowly to pharmacological treatment alone tory pressure (PEP) mask, autogenic drainage (AD),
(Asher, Douglas, Airy, Andrews, and Trenholme, and use of the flutter device, have been shown to be
1990). Exercise, also highly effective in the treatment effective in assisting sputum expectoration, often in
and management of asthma, is discussed in a later greater amounts and in less time per treatment
section on pulmonary rehabilitation. (Konstan, Stern, and Doershuk, 1994; Mahlmeister,
Fink, Hoffman, and Fifer, 1991; Pryor, 1991; Pryor
Cystic fibrosis
and Webber, 1979; Schoni, 1989).
Cystic fibrosis (CF) is a complex autosomal-reces Although postural drainage, percussion, and vibra
sive disorder that affects the exocrine glands. Defini tion remain the treatment of choice for infants and
tive diagnosis of CF includes positive family history, children who are unable to be instructed in tech
obstructive pulmonary disease, recurrent pulmonary niques that use patterns of voluntary breathing, other
infection, intestinal malabsorption and poor growth, techniques are available for children who can follow
the presence of Slaphylococcus aur eus or specific breathing instructions and who can perform a
Pseudomonas aeruginosa i n the respiratory tract, reliable pulmonary function test. Children as young
and, most importantly, a positive sweat chloride test as 2 to 3 years can be taught to "huff' as part of FET
(Cystic Fibrosis Foundation, 1990). (Pryor, 1991), the PEP mask has been used with chil
The chronic pulmonary disease in CF is related dren as young as 3Y2 years (Mahlmeister et aI., 1991),
to increased secretion of a b n o rm a lly v i s c o u s and AD can reportedly be taught to children as carly
mucus, impaired mucociliary transport, airway ob as 4 to 6 years of age (DeCesare and Graybill, 1990;
struction, bronchiectasis, overinflation, and infec Sci1oni, 1989). The benefits of each technique should
tion. Radiographic changes are most pronounced in be carefully considered relative to each child's cogni
the upper lobes, especially the right (Wood, Boat, tive, respiratory, and motor planning abilities when
and Doershuk, 1976). choosing or modifying the child's program for airway
The early institution of prophylactic pulmonary clearance.
physical therapy, including postural drainage and the Ventilatory muscle training is an important aspect
judicious use of antibiotics, provides effective mea of pulmonary treatment in older children with CF.
sures for controll ing or slowing the effects of bron Studies have demonstrated that training to improve the
chiolar and bronchial obstruction. Involvement of the endurance of ventilatory muscles decreases dyspnea
child and family in pulmonary care is particularly im and increases general exercise tolerance in patients
portant. Family understanding of the nature of the with CF (Keens, Krastins, Wannamaker, Levison,
disease and the purpose of each therapeutic measure Crozier, and Bryan, 1977; Reid and Loveridge, 1983).
promotes successful management of the child. A The role of general exercise in the cardiopul
home program of CPT should be established for each monary management of children with CF is specifi
child, taking into consideration the child's ongoing cally discussed within the context of pulmonary reha
pulmonary needs and the family's unique contribu bilitation. However, it is important to realize that
tions and constraints. some debate exists as to whether exercise can replace
Bronchial drainage is an aspect of conventional more traditional airway clearance techniques. Pryor
treatment for CF that in recent years has gained sev (1991) has suggested that exercise should be an addi
eral options that allow both efficacy and patient in tional component rather than a substitute for breath
dependence (Davis, 19(4). Airway clearance tech ing techniques. Cerney (1989) in contrast, reported
niques are described in detail in Chapter 20, but that some children with mild disease may be able to
alternatives to traditional percussion and postural use regular exercise in place of bronchial drainage
drainage warrant mention within the context of CPT treatments. The severity of the disease process and
for children with CF. Specifically, the forced-expi the child's condition at any one point in time, will
ration technique (FET) as part of the active cycle of clearly mediate the appropriateness and effectiveness
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644 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
of exercise as either a component or as a primary These deviations and other aspects of ventilatory
means of airway clearance. compromise are discussed with regard to motor diag
noses common to pediatric practice.
Special respiratory problems associated
with intubation and tracheostomy Cerebral palsy
Once an infant or child develops respiratory failure, Children with cerebral palsy generally have weak trunk
intubation and mechanical ventilation are usually re and postural muscles, which, when combined with atyp
quired. The goals of medical management are then to ical neural mechanisms, produce atypical movement
treat the cause of the respiratory failure as aggres pattems and functional alignment deviations. The trunk
sively as possible and to wean the child from me and respiration relationshi[ls described in Table 35-3 are
chanical ventilation as quickly as possible. consistent with the clinical picture of external pul
If a child's condition necessitates long-term me monary development in children with cerebral palsy.
chanical ventilation, or if an artificial airway is needed Although the extent of mobility impair ment is
to bypass an upper airway obstruction, a tracheostomy variable between children, hypoventilation, increased
is usually petformed (Scott and Koff, 1993). work to breathe, inefficient cough, increased risk for
Infants and children who have a tracheostomy and aspiration, and poor breath support for vocalization
are intubated for long periods of time require vigorous can occur (Alexander, 1993). Limited active mobility
prophylactic airway management, such as bronchial and the use of habitual patterns with little deviation
drainage and airway suctioning. Chest PT, including
postural drainage and vibration emphasizing right
upper lobe segments, has been shown to significantly
decrease the incidence of postextubation atelectasis in
infants intubated for more than 24 hours (Finer, Mori
artey, Boyd, Phillips, Stewart, and Ulan, 1979).
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35 The Neonatal and Pediatric Patient 645
TABLE 35-3
Tight pectoralis minor Forward shoulders Anterior upper chest cannot adequately
Scapula pulled laterally and anteriorly, expand
away from the thoracic wall
Upper thoracic flexion
Weak serratus anterior Wcak upper fibers-medial edge of Decreased structural reinforcement
scapula Icaves the thoracic wall of the posterior chest wall
Interdigitation of the lower fibers of
serratus anterior with the external
abdominal oblique will interact to
affect the dynamic stability of the
rib cage
Decreased rib cage stability Serratus anterior will elevate the ribs Decreased structural support for the
rather than stabilize the scapula respiratory muscles to work from
against the thoracic wall
Modified from Moerchen V A: Respiration and motor development: a systems perspective, Neural Rep 18 (3): 8-10, 1994. Reprinted from
the Neurology Report with the permission of the Neurology Section, APTA.
of the center of gravity beyond the base of support chest excursion and should be incorporated into a
contribute to thoracic stiffness. A high chest, flat home program. Mobilization of the ribs and thoracic
tened anteriorly, with excessive rib flaring, is com spine are important precursors to improving chest ex
mon in these children (Figure 35-l). cursion during ventilation.
Therapeutic attention to respiration should first Chest PT may be indicated if the child develops a
identify possible aspiration and suggest modifications primary pulmonary complication. Prophylactic pos
for positioning during feeding. Additionally, certain tural drainage can also be integrated into many sen
postures for sleep and play may be less restrictive for sory stimulation programs for more severely involved
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646 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
Myelomeningocele
Myelomeningocele or spina bifida are diagnoses that
physical therapists generally equate with issues of am
bulation and mobility. However, central ventilatory
dysfunction is prevalent in infants, children, and ado
lescents who also have an associated Arnold-Chiari
type II malformation (Hays, Jordan, McLaughlin,
Nickel, and Fisher, 1989; Swaminathan et aI., 1989;
Ward, Jacobs, Gates, Hart, and Keens, 1986).
The Arnold-Chiari type II malformation, which oc
curs in 90% of infants with myelomeningocele, is a
hindbrain malformation consisting of a caudal helllia
tion of the cerebellum and brain stem into the cervical
canal (Charney, R orke, Sutton, and Schut, 1987).
Ventilatory problems associated with a symptomatic
Arnold-Chiari type II malformation include inspira
tory stridor (vocal cord paralysis), central apnea, and
respiratory distress (Hays et aI., 1989; Hesz and Wol
raich, 1985; Oren, Kelly, Todres, and Shannon, 1986).
However, abnormal ventilatory patterns have also
FIGURE 35-2
been observed in asymptomatic infants (Ward et aI.,
An 8nterior cut-out and elastic support in a body
1987) and adolescents (Swaminathan et aI., 1989).
jackel/spinal orthosis aids diaphragm function.
Ventriculoperitoneal shunting (management of hy
drocephalus) and, if necessary, cervical decompres
sion are the surgical approaches to treatment of life
threatening ventilatory complications in this population.
Down syndrome
Other p u lmonary issues in c h ildren with Impaired pulmonary function in children with Down
myelomeningocele warrant discussion. TtUnk weakness syndrome is clearly related to generalized weakness of
and hypotonia are observed early in the motor develop trunk musculature (Dichter, Dm·bee, Effgen, and Pal
ment of infants and toddlers who have shunted hydro isano, 1993). The postural deviations common in these
cephalus. Additionally, in children with thoracic and children reflect (Figure 35-3) inefficient muscle func
high lumbar level lesions, abdominal muscle SUpp0l1 for tion for both ventilation and movement (Moerchen,
diaphragm function may be insufficient. The use of ab 1994). Again the ttUnk-ventilation relationships delin
dominal binders, and spinal othoses/body jackets with eated in Table 35-3 summarize the subtle but significant
(anterior) diaphragm cut-outs and an elastic inse11 are clinical presentation of external pulmonary develop
indicated to aid in diaphragm function (Figure 35-2). ment in these children. Too often only motor develop
Although progressive scoliosis is not the natural history ment is addressed by physical therapists who are treat
of children with spina bifida, it is a symptom of unstable ing children with Down syndrome. Respiration needs to
neurology (tethered cord), and attention to ventilatory be considered if therapy goals include increased vocal
ability is necessary both for general monitoring and for izations or improved tolerance for exercise.
possible preoperative evaluation. Pulmonary hypoplasia may also challenge the res
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35 The Neonatal and Pediatric Patient 647
FIGURE 35·3
A, Characteristic posture of a child with Down syndrome/hypotonia. Note the abdominal protrusion
and sternal retraction. B, Rib flaring with upper extremity movement; the abdominal obliques are
not stabilizing the lower ribs.
Photos from Moerchen, V.A. (1994). Respiration and Motor Development: a Systems Perspective.
Neurology Report, 18(3), 8-10. Reprinted with the permission of the Neurology Section, APTA.
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648 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
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35 The Neonatal and Pediatric Patient 649
Chest Physical Therapy for Neonates and Infants I. Care should be taken to coordinate any change
in the infant's position with other nursing proce
The plimary goal of chest physical therapy for neonates
dures to avoid unnecessary stimulation.
and infants is to improve airway clearance. If tech
2. Infants should never be left unattended when in
niques of bronchial drainage can increase the diameter
a head-down position.
of the airways through secretion mobilization, then
3. Vital signs should be monitored closely by res
ventilation may also be improved and the work of
piration and heart rate monitors. The alarms
breathing reduced. These techniques should be judi should be turned on.
ciously applied for prophylaxis and treatment in infants
4. The infant's chest should be auscultated for ad
who have or are at risk for developing airway clearance ventitious breath sounds after positioning.
problems. Applying bronchial drainage techniques to
5. While the infant is in a drainage position, secre
infants requires a thorough understanding of each in tions will be more easily mobilized. The infant's
fant's condition and the precautions and considerations trachea or endotracheal tube should be suctioned
inherent to any technique or combination of techniques. as needed.
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650 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
J. ��
FIGURE 35-4
Sequence for positional rotation.
Position I.-Segments that come off the left lower bronchus posteriorly are drained by positioning
the infant on his right side, three-foUl1hs prone with a head-down angle. Position 2.-The posterior
segment of the right upper lobe is drained by positioning on the left side, three-fourths prone with
the bed flat. Position 3.-The anterior segments of the upper lobes are drained by positioning
supine with the head of the bed elevated or flat. Position 4.-Segments that come off the right
lower lobe bronchus posteriorly are drained by positioning on the left side, three-fourths prone with
a head down angle.
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35 The Neonatal and Pediatric Patient 651
4.
5.
FIGURE 35-4-cont'd
Position 5.-The posterior segment of the left upper lobe is drained by positioning on the right
side, three-fourths prone with the head of the bed elevated. Position 6.-Segments that come off
the tracheobronchial tree anteriorly are drained by positioning supine with a head-down angle.
Positu)1Is 7 and 8.-Segments such as the right middle lobe or lingula that come off the
tracheobronchial tree anterolaterally will be drained in a three-fourths spine position, slightly head
dow (see Figure 35-5, p. 652).
NOTE: Babies on ventilators may also be positioned prone. This is usually done by the therapist
rather than in a routine positional rotation (see Figure 35-6, p. 652).
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652 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
monary benefit, it may also contribute to the disrup ing less than 800 grams) usually require and benefit
tion of homeostasis that has been documented to from modification of the head-down position. Hori
occur in the course of neonatal intensive care (Long, zontal to slightly elevated positioning of the head may
Philip, and Lucey, 1980; Yeh, Lilien, Leu, and be best (Thoresan, Cowan, and Whitelaw, 1988). This
Pildes, 1984). Use of nursery beds that provide con modification primarily is due to the high incidence of
tinuous positional oscillation (from right side to intraventricular hemorrhage in premature infants
supine to left side, and so forth) might provide an op (Crane, Zombek, Krauss, and Auld, 1978; Emery and
tion that allows the benefits of position change while Peabody, 1983). Other precautions for Trendelenburg
also minimizing the homeostatic disruption. Murai positioning of infants include but are not limited to
and Grant (1994) demonstrated that continuous posi abdominal distention, congestive heart failure, dys
tional oscillation as part of a total chest physical ther rhythmias, hydrocephalus, frequent episodes of apnea
apy program decreased the duration of oxygen sup and bradycardia, and acute respiratory distress.
p l e m e n t a ti o n w i t h o u t a d v e r s e ly e f f e c t i n g t h e
cardiopulmonary status o f the neonates.
Chest percussion and vibration
Percussion and vibration are used in conjunction with
Postural drainage postural drainage to augment the effect of gravity in
Postural drainage (PD) positions to promote gravity the removal of secretions. There are several ways to
assisted drainage of specific segmental airways can be perform percussion on infants. For a larger infant, it
safely applied to infants and children. In the acute care is possible to use a cupped hand, similarly to per
setting, however, many of the head-down positions cussing an adult's chest. For a smaller infant, some
are modified according to tolerance and precautions or modification of this technique is needed. Chest per
contraindications (Table 35-4). The rule for modifica cussion for a smaller infant is accomplished by the
tion of any position for PD is that the position used use of tenting three fingers, four fingers, or using any
should be as close to the classical (anatomically cor of the commercially available percussion devices
rect) position for that segment as safely possible. Ex made for neonates (Figure 35-8). A small anesthesia
amples of the classical PD positions for each bron mask or "palm cup" can also be used effectively.
chopulmonary segment are pictured in Figure 35-7. Precautions for chest percussion in the infant in
Tiny infants (especially premature infants weigh- clude but are not limited to unstable cardiovascular or
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3S The Neonatal and Pediatric Patient 653
TABLE 35-4
oxygenation status (although percussion may be pro bration will depend on the day-to-day medical status of
vided safely if continuous transcutaneous monitoring the infant and the infant's response to treatment.
is available), coagulopathy, subcutaneous emphy
sema, or intraventricular hemorrhage. Additionally,
Airway suctioning
percussion is generally contraindicated over a healing Sterile airway suctioning is discussed in detail in
thoracotomy incision or if the child displays ilTitabil Chapter 42. However, some special considerations
ity and signs of rcspiratory distress with the treatment. for suctioning the a i rway of an infant need to be
Vibration is accomplishcd either through manual vi highlighted (Durand, Sangha, Cabal, Hoppenbrowers,
bratory motion of the therapist's fingers on the infant's and Hodgman, 1989; McFadden, 1981; Perlman and
chest wall (Figure 35 -9) or through the use of a me Volpe, 1983).
chanical vibrator. An electric toothbmsh can be adapted 1. If possible, suction with a transcutaneous oxy
by padding the bristle portion with foam (Cun'an and gen monitor in place. These monitors give con
Kachoyeanos, ) 979). Vibration has been observed to tinuous feedback regarding the infant's oxy
occasionally increase irritability and may be less well genation status.
tolerated than percussion. The most common precau 2. Bagging should be done only with a bag at
tion for vibration is increased irritability with the devel tached to a pressure manometer to ensure that
opment of bradycardia alld respiratory distress. sufficient prcssures are being used without ex
The decision to use chest percussion and vibration ceeding the maximum safe le v els (these l imits
will depend on the reviewed principles and precautions, should be similar to the ventilator settings).
the medical condition of the infant, and the infant's tol 3. Suction for no more than 5 seconds with each
erance to handling. Continuation of percussion and vi catheter withdrawal.
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654 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cllses
A - --:--- '- B
C :.- D
FIGURE 35-7
Postural drainage with an infant. A, Both upper lobes-apical segments. B, Left upper lobe-
anterior segment. C, Right upper lobe-anterior segment. D, Lingula.
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35 The Neonatal and Pediatric Patient 655
E F
G H
FIGURE 35-7-cont'd
E, Right middle lobe. F, Right upper lobe-posterior segment. G, Left Lipper lobe-posterior
segment. H, Both lower lobes-apical (superior) segments.
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656 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 35-7-cont'd
I, Both lower lobes-anterior basal segments. J, Left lower lobe-lateral basal segment; Right
lower lobe arduac (medial) segment. K, Both lower lobes-posterior basal segments. L, Right
lower lobe-lateral basal segment.
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35 The Neonatal and Pediatric Patient 657
FIGURE 36-8
'Tenting" of the finger for percussion of premies or small children.
FIGURE 36-9
Manual chest wall vibration of a premie.
4. Infants should be carefully hyperoxygenated tions and imitating a therapist's demonstration of deep
when hyperventilated so as to minimize hyper breathing, coughing, and active exercise. Chest physi
oxia and hypoxia. Bagging usually does not cal therapy in children is focused on improving venti
need to continue for more than 5 to 10 seconds lation, improving the efficiency of breathing, increas
to maintain adequate oxygen levels. ing general strength and endurance with an emphasis
5. Monitor the blood pressure of preterm infants be on muscles of respiration, improving posture, and ad
fore, during, and after suctioning. Change in dressing relaxation, breathing control, and pacing.
blood pressure may indicate increased intracra The application of chest PT with children often re
nial pressure and risk for intracranial hemOtThage. quires patience and creative adaptation (Figure 35-
10). The challenge is to make it seem less like a treat
ment and more like a game. It is important, however,
Chest Physical Therapy for Children
to be honest in your explanations and to speak to the
The goals for chest physical therapy with children (2 child with respect and at a level appropriate to the
years and older) include more than improving airway child's age and development.
clearance. Children are capable of following direc Involving the family in PT treatment of a child can
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658 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 36-10
A, B, C, Few areas of health care delivery require creative adaptation and problem solving to the
extent that pediatrics does.
be invaluable. In some cases the parent may do most tant to have his position changed, changing the loca
of the "hands-on" and repeat instructions to the child tion of the television may be helpful. Be creative!
under the direct guidance of the therapist. This Young Children. In younger children (18 months to 3
arrangement will also help reinforce parent and fam years) deep breathing is usually encouraged by blow
ily education for carry-over of home therapy. ing bubbles, tissue paper, mobiles. or simple horns. To
achieve maximal chest expansion, the child should be
Positional rotation
positioned on each side while playing blowing games
The goal of positional rotation and postural drainage or singing. The theory behind the side lying position is
is to prevent the accumulation of secretions and to aid that the downside lung ventilates more effectively (see
in their removal. Any child who is immobile, receiv Chapter 18). Additionally, if the poorly ventilated
ing artificial ventilation, or not expanding his chest lung is uppermost, stretch techniques can facilitate
adequately should have his position changed at least deeper breathing (see Chapter 22).
every 2 hours. Recall that positional changes will en Spontaneous coughing in younger children often
hance oxygen transport and promote pulmonary occurs with a change in position or with crying. For
drainage (Ross and Dean, 1989). If the child is reluc the child who does not cough spontaneously or whose
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35 The Neonatal and Pediatric Patient 659
FIGURE 35-11
Whistles such as these encourage increased inspiration and controlled, sustained expiration to make
the whistle components move (left: a fish with a wheel that moves at its back fin; middle: a race car
that drives around a track making whirling sounds; right: a ball that moves up and down in a train).
cough is inadequate to clear secretions, nasopharyn treat ment by therapists helps to decrease the inci
geal suctioning may be necessary. dence of postoperative complications.
Older Children. School-age children can be more Preoperative teaching is extremely important for
specifically instmcted in various breathing exercises, both the child and the family. Parents can often be
such as diaphragmatic breathing, pursed-lip breathing, more anxious than the child, so patient and family ed
and segmental lateral costal breathing. They may also ucation is important. The level of preoperative train
be candidates for using relaxed deep breathing for ing with the child will depend on the child's age.
control and pacing of activity. Cooperation with this If the child is very young (under 2 years), the thera
age group, however, still remains higher if some as pist will meet with the parents and explain the purpose
pect of therapy is fun. Elaborate whistles are available of bronchial drainage treatments, potential airway clear
that encourage deep breathing as a fun means to an ance problems, and possible complications. The pre
end of making the whistle components move (Figure ventative nature of these treatments should be stressed,
35-11). Additionally, pediatric incentive spiro meters and procedures that might be done with the child after
are available with cheerfull"cool" pictures to make surgery should be demonstrated and discussed. These
respiration exercises more like a game (Figure 35-12). might include: (I) positioning, (2) chest percussion,
Older children (not infants) can be stimulated to (3) vibration, and (4) airway suctioning. In addition, al
cough by applying a firm pressure over the trachea in ways allow time for the parents to ask questions.
the suprasternal notch. Beware t h a t coughi ng, If the child is able to understand simple concepts,
whether spontaneous or stimulated, may elicit gag the therapist can, in addition to parent orientation, in
ging and vomiting, especially if airway clearance is stmct the child in various breathing games, use of an
scheduled too soon after a child has eaten. incentive spirometer, coughing, and general upper
and lower extremity exercises.
Preoperative and postoperative care In older children (8 years or older), postoperative
The efficacy of postoperative chest PT is highly re procedures can be explained and demonstrated. The
lated to preoperative care. The appropriate applica importance of bronchial hygiene should be stressed
tion of preoperative assessment, instruction, and during demonstration of deep breathing and cough
Copyrighted Material
660 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 35-12
A pediatric incentive spirometer. (Photo provided courtesy Pediatric Pulmonary Rehabilitation
of DHD Medical Products. Used by permission.)
Rehabilitation programs for pediatric patients with
chronic lung disease include the same components
and have essentially the same goals as adult pul
ing. The child can be shown how to splint the inci monary rehabilitation. The major difference is related
sion using a pillow or stuffed animal to assist with to different diagnoses being most prevalent in the
comfort while coughing. Do not tell the child that children versus adult age groups. Asthma and CF are
coughing will not hurt; be honest but reinforce that the most common diagnoses of children who are can
splinting will help. Teach the child diaphragmatic didates for pulmonary rehabilitation.
and pursed-lip breathing with an inspiratory-hold ma
neuver, and, if appropriate, teach the child how to use
Exercise and asthma
an incentive spirometer. Exercise and conditioning are very important compo
Postoperative pulmonary complications may not nents of the treatment of the child with asthma. Im
be as prevalent in the pediatric age group as in adults, proved chest and trunk mobility, control of breathing,
but they still occur. The most common complications strength, posture, and an increased tolerance to exer
Copyrighted Material
35 The Neonatal and Pediatric Patient 661
cise are all goals that can be addressed in the design oxygen desaturation during exercise in children with
of exercise programs for these children (Magee, CF (Coates, 1992). Loutzenhiser and Clark (1993),
1991; Seligman, Randel, and Stevens, 1970). however, suggested that severity of CF is not the pri
Part of a pulmonary rehabilitation program may mary limiting factor in the exercise capacity of these
involve providing recommendations for the child's children. Clearly, any aerobic exercise program de
participation in physical education (PE). Certain as signed for older children with CF will require careful
pects of exercise relative to pul monary function in monitoring of pulmonary support during exercise.
children with asthma need to be communicated to the
PE teacher. Running is the form of exercise most
Motor Approaches to Maximize Trunk
likely to aggravate exercise-induced asthma, espe
and Ventilatory Function
cially if performed in a cool, dry environment. Swim
ming, by contrast, is an excellent activity. Continuous Attention to pulmonary function is easily accom
or high burst exercise might induce bronchospasm, plished within any "handling" approach to motor
whereas short periods of exercise (less than 6 contin therapy for children with trunk weakness, tightness,
uous minutes) may be beneficial for conditioning alterations in tone, or general immobility. Most "han
wi thout bronchial aggravation (Magee, 1991). PE dling" consistent with a neurodevelopmental tech
teachers should also be aware that the child may need nique (NDT) approach lends itself readily to a dual
to use a preexercise aerosol to participate in PE with focus on movement quality and ventilation. Extrinsic
out pulmonary consequence (Magee, 1991). pulmonary development is clearly interrelated with
musculoskeletal and motor development of the trunk.
Exercise and cystic fibrosis
Treatment should begin with assessment and ini
Physical activity designed to improve exercise toler tial handling for functional range of motion through
ance helps children with CF to mobilize secretions the trunk. This will typically require elongation of the
and to improve body image. The development of an pectoral, sternocleidomastoid, upper trapezius, and
exercise program for children with CF should be done rectus abdominis muscles. Manual lowering of the rib
on a individualized basis and a preexercise assessment cage will also be necessary to work toward maximiz
should include but not be limited to the following: ing chest mobility (Figure 35-13).
I. Assessment of range of motion, strength, and Passive elongation of muscles must always be
posture. followed by active elongation. Controlled prone
2. Complete chest evaluation. extension off the ball is both fun for the child and
3. Evaluation of ADL tolerance and limitations. effective for the therapist (Figure 35-14). Manual
4. Inspiratory muscle strength (maximal inspira guidance for upper extremity abduction and exter
tory ncgativc pressure at the mouth) and en nal rotation will facilitate active elongation of the
durance testing. This inspiratory endurance pectoral muscles via active firing of the scapular
testing can be done with an inspiratory muscle retractors. The ball can be used to impart move
training device by having the child breathe for ment and support the lower rib cage. This elon
a predetermined length of time at progressively gates the anterior trunk (rectus abdominis), length
increased resistances until tolerance is reached. ens intercostal muscles, and facilitates increased
5. Exercise tolerance testing, performed with upper chest expansion.
ECG, blood pressure, and oxygen monitoring. Handling to achieve proprioceptive input of the
A basic exercise program for children with CF scapulae on the posterior thorax, will help reinforce
should include activities to strengthen the back and active thoracic extension and anterior chest expan
shoulder extensors, to elongate the trunk t1exors, and sion. The therapist's hands can stabilize the rib cage
to address overall endurance. The role of more vigor to reinforce abdominal oblique function during
ous exercise and fitness training in these children is a movement (Figurc 35-15).
issue of debate, based on inconsistent incidence of Activities requiring alternating extension-rotation
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662 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 35-13
Handling to facilitate active upper thoracic extension, as a Handling to reinforce upper chest expansion and abdominal
means of actively opening the anterior chest and oblique stabilization of the lower ribs.
Copyrighted Material
35 The Neonatal and Pediatric Patient 663
and flexion-rotation will recruit control of the abdom 4. Compare the goals of chest physical therapy for
inal obliques and maintain active upper trunk exten infants and older children. What are the similari
sion. Bubble blowing, whistle toys, and singing are ties and differences?
excellent means o f monitoring the ventilatory 5. When treating infants to improve airway clear
changes that occur with active use of increased upper ance, what are the precautions/considerations of:
chest expansion. As tidal volume increases, vocaliza • positional rotation?
tions should increase in frequency, sound higher, and • postural drainage?
become louder. • percussion?
The concept of functional carry-over is central to • vibration?
the treatment approach presented here. Addressing • airway suctioning?
ventilation and trunk control simultaneously has intu 6. How might neuromotor (neuromuscular) dys
itive appeal based not only on shared musculoskeletal function affect pulmonary development and con
relationships but also on the necessity of pulmonary , tribute to possible postoperative complications?
tolerance for motor activity. 7. Describe goals, precautions, and suggested monitor
ing for exercise in children who have the following:
• a history of cardiac surgery
SUMMARY
• asthma
Cardiopulmonary physical therapy with infants and • cystic fibrosis?
children is presented starting with issues related to
development and developmental vulnerabilities. Spe
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35 The Neonatal and Pediatric Patient 667
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Copyrighted Material
The Aging Patient
Elizabeth J. Protas
669
Copyrighted Material
670 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
encountered in elders. It may be more uncommon to characteristics of aging. The impact of various dis
have a person over age 75 without any problems than to eases is discussed in other chapters. Psychosocial is
have a healthy older individual. As a physical therapist, sues related to exercise and aging are not discussed.
I may be more interested in the responses of a frail 85
or 90-year-old woman who has a history of hyperten
CARDIAC CHANGES WITH AGING
sion, coronary artery disease, and diabetes than some
one who is healthy at this age because this reflects the
Aerobic Capacity
population who is referred to physical therapy. The oc
currence of disease states in study populations may im The aerobic capacity is the maximum ability to per
pact the cardiopulmonary responses to exercise. Fi form exercise with large muscle groups. This ability
nally, the study of the physiological aspects of exercise is produced by the interaction of the lungs, heart, and
and aging is still evolving. The literature can be confus peripheral tissues. The most common indirect mea
ing and contradictory, making conclusions and general sure of the aerobic capacity is the maximum oxygen
izations difficult. An attempt is made to provide some consumption (Vo2ma,), or the maximum oxygen used
direction in this confusing maze of infonnation. during exercise. The Vo2max is directly related to the
An additional issue is a model of aging that might cardiac output (the amount of blood pumped by the
sort out some of the determinants of aging. (Figure heart) and the arteriovenous oxygen difference (the
36-1) The model identifies biological factors, disuse, amount of oxygen extracted in the periphery). The
disease, and psychosocial concerns as determinants of cardiac output is the product of the heart rate times
aging. Biological factors address genetics, gender, cel the stroke volume. The aerobic capacity reflects the
lular mechanisms, and metabolical, and physiological central cardiac function and the efficiency of the pe
responses that influence aging. Disuse is implicated in ripheral tissues to extract and use oxygen.
more sedentary life styles led by many elders, which The Vo2max declines with age between 0.40 to
results in loss of exercise capacity (Bortz, 1993). Ca 0.50 ml/kg/min per year in men and between 0.20 to
pacities that decline as a result of disuse should be re 0.35 mllkg/min per year in women (Figure 36-2)
versible or attenuated with exercise training. The em (Buskirk and Hodgson, 1987). The reduction is ap
phasis in this chapter is on the biological and disuse proximately 10% per decade. The decline is larger in
V02max
50 (ml/kg/min)
1
45
40
35
30
Disuse 25
I 20
15
10
5
Biological
factors -- L:J --
Psychosocial
factors o 20-29 30-39 40-49 50- 59 60- 75
Age (years)
FIGURE 36-2
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36 The Aging Patient 671
men than women; however, the capacity of the males ation of the myocardial fibers, sufficient venous re
is larger than the females (Hossack and Bruce, turn to rapidly fill the heart, and the timing of the
1982). Vo2max is related to body size, which tends to atrial contraction to contribute to the end diastolic
be smaller in women than men. Increases in body volume. Relaxation is hampered possibly by an in
weight as people age results in reduced V02max even crease in ventricular stiffness, although there is lim
if the aerobic capacity remains the same, since rela ited evidence of this in humans (Lakatta, 1993). The
tive oxygen consumption is related to body weight. period of the isovolumic myocardial relaxation (be
Reduced physical activity with aging also con tween aortic valve closing and mitral valve opening)
tributes to a loss of Vo2ma". is prolonged. Likewise the peak rate of left ventricu
Considerable disagreement exists about the mecha lar filling during early diastole is reduced in older,
nisms that contribute to the decline in V02max with healthy men and women compared with younger in
age. Both cardiac and peripheral changes contribute to dividuals. Despite the changes in early diastole, the
the loss. A reduction in maximum cardiac output ac resting left ventricular end-diastolic volume remains
counts for 50% to 100% of the total reduction in the same because of an enhanced left atrial contribu
V02max (Dempsey and Seals; Ogawa et aI., 1992; tion to ventricular filling. This is accompanied by an
Saltin, 1986). Decreased maximum arteriovenous enlarged left atrium and an audible fourth heart sound
oxygen consumption accounts for whatever is not due in most older adults (Lakatta, 1993; Fleg, Gersten
to decreased maximal cardiac output. A major compo blech and Lakatta, 1988).
nent to the decline in maximal cardiac output is a de Considerable disagreement exists about what hap
creased maximal heart rate (Ogawa et aI., 1992; Hag pens to diastolic function during exercise. Some re
berg, 1987). The decline in heart rate is linearly cent studies suggest that end-diastolic volume during
related to age and occurs in both sedentary and active exhaustive exercise increases in older men but not it
elders (Sidney and Shephard, 1977). Reduced maxi women (Lakatta, 1993). Filling pressures during ex
mal stroke volume has also been observed as people ercise in men increase with age (Ehrsam, Perruchoud,
age (Ogawa et aI., 1992) Recent studies suggest de Oberholzer, Burkhart, and Herzog, 1983). In addi
creased stroke volume is associated with a decrease in tion, peak left ventricular diastolic filling rate during
total blood volume in healthy older men and women submaximal and maximal exercise decreases with
(Dempsey and Seals, 1995; Davy and Seals, 1994; aging (Levy, Cerqueria, Abrass, Schwartz, and Strat
Stevenson, Davy, Reiling, and Seals, 1995). Most evi ton, 1993; Schulman, Lakatta, Fleg et al. 1992) De
dence suggests that decreased V02max with aging is re creased filling rate is associated with increased ven
lated to decreased maximal heart rate, stroke volume, tricular stiffness and prolonged relaxation times
and arteriovenous oxygen difference, although each (Ehsani, 1987).
component's contribution varies (Dempsey and Seals, Resting measures of systolic and cardiac pump
1995; Lakatta, 1993), function do not change with aging. The resting end
systolic volume and stroke volume do not change
with age. Likewise, the ejection fraction at rest (end
Cardiac Mechanics
diastolic volume - end-systolic volume/end-diastolic
The most consistent cardiac structural change is a volume) is similar in healthy older and younger indi
modest increase in left ventricular wall thickness in viduals (Lakatta, 1993).
80 year olds compared with 20 year olds (Lakatta, Unlike resting systolic function, the pumping func
1993), attributed to an increase in size of cardiac my tion of the heart changes considerably in response to
ocytes and is exaggerated by hypertension and/or exercise. Myocardial contractility as measured by the
coronary artery disease (Lakatta, 1993). After age 80, ratio of end-systolic volume to systolic arterial pres
the left ventricular wall thickness again decreases. sure declines during exercise as people age (Lakatta,
The cardiac filling or diastolic properties of the 1993). The end-systolic volume increases, whereas
heart are altered with age. Diastole requires a relax the ejection fraction decreases during exercise. These
Copyrighted Material
672 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Special Cases
changes reduce stroke volume exercise. Re catecholamines is most often cited as the reason for
duced contractile performance is related to a decrease "' "<"vu in maximal heart rate with (Rodehef
in the response to beta-adrenergic stimulation, f e r, Gerste nbl Beck er, W e i sfeld, and
changes in the myocardium, increased blood Lakatta, 1984). Relatively intense endurance training
pressure, a n d v e n t r i c u l a r w a l l abnorma l i t i e s for a year or more can increase stroke volume in
(Dempsey and 1995). Ogawa, Miller, and Jilka, 1991;
Spina, and
Adaptations to exercise training in
Impact of Training on Aerobic Capacity
older women have been attributed to
and Cardiac Mechanics
in arteriovenous oxygen differ
Older persons who continue to be active reduce the ence rather than central changes in cardiac function
rate of decline in Vo2max to 5% per decade compare (Spina, Kohrt, Martin, Holloszy, and Ehsani,
with an decline of 10% per decade in 1993). This apparently occurs desoite intensive en
sedentary adults 1987). A recent metaanaly durance over a year-long
sis of 29 studies including 1030 men and 466 women The diastolic changes thal occur with can be
between the ages of 61 and 78 and endurance train- reversed by exercise training et al., 1993).
concluded that endurance Levy et al. endurance trained 13 rigor-
increases functional in young elders screened older men 60 to 82 age
and Less improvement was seen with 68) and II younger men in their twenties for 6
increasing age, a shorter length of low months. The training increased submaximal,
Vo2rnax before and short duration of exercise and rates for the older group comparable
sessions. The analysis suggests that a 68- with the seen in the younger group (Levy et
year-old individual who exercises for 30 minutes aI., 1993). End-diastolic peak volume at rest and ex
three times per week for 4 to 6 months can improve ercise also increase after lengthy endurance training
14% and 1 Similar (Ehsani et 1991). Thus reduces the age
occur in both men and women (Kohn, associated diastolic changes. The mechanisms of this
1991; Warren et response are uncertain in humans. Studies in rats
The mechanisms underlying in have shown that exercise training increases calcium
Vo2max i n the with endurance are not in cardiac decreases
clear. One consistent finding is greater extraction of relaxation reduces the decline of left ventricular
oxygen in the exercising skeletal which pro pressure, enhances fatty acid oxidation, and increases
duces a wider arteriovenous oxygen difference in c oxidase levels
both older men and women 1992; and Stratton, I Taffet,
skeletal muscles account for some of the and Edington, 1 All of these
increase in in elders. The of exercise have been associated with reduced diastolic
Copyrighted Material
36 The Aging Patient 673
Copyrighted Material
674 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
during exercise normally involves the shunting of chest wall (Dempsey and Seals, 1995). The lung's
blood from inactive limbs and viscera. There seems to elastic recoil depends on the composition of the con
be an enhanced vasoconstriction in inactive muscles nective tissue, the structure of the connective tissue,
during dynamic exercise in healthy older men (Taylor, and alveolar surface tension produced by surfactant
Hand, Johnson, and Seals, 1992). (Dempsey and Seals, 1995). Very limited evidence
suggests that the structure of the connective tissue
may be the primary mechanism for age-associated
Effect of Exercise Training on Vascular
change in elastic recoil. Chest wall stiffness is ac
and Autonomic Function in Aging
companied by an increase in chest anterioposterior
Exercise training improves peripheral bloodflow in diameter, coastal cartilage calcification, nan'owing of
skeletal muscle in 60-year-old men and women (Mar the intervertebral disks, and changes in the rib to ver
tin, Ogawa, Kohrt, Malley, Korte, and Stoltz, 1991). tebrae articulations (Crapo, 1993).
Systolic and mean arterial blood pressure responses Decreases occur with the alveolar-capillary sur
to submaximal exercise are lower in physically active face area, the alveolar septal surface area, and the
adults compared with sedentary individuals (Martin total surface area of lung parenchyma (Brody and
et aI., 1991). Endurance training also increases mus Thurlbeck, 1985). This reduces the surface area avail
cle sympathetic nerve activity and plasma norepi able for gas exchange.
nephrine concentrations at rest and during a moderate Loss of elastic recoil with aging is directly associ
isometric handgrip, indicating elevated sympathetic ated with reduced forced expiratory flow. Limitations
nerve activity in response to exercise (Table 36-2) in exhalation are caused by airway narrowing and
(Ng, Callister, Johnson, and Seals, 1994). closure at all lung volumes; thus reducing forced ex
piratory volume in I second (FEV1) (Dempsey and
Seals, 1995) Early airway closure also produces an
PULMONARY FUNCTION
early closing volume and a relati ve increase in the
total residual volume. The combination of reduced
Structural and Functional Changes With Aging
elastic recoil and increased chest wall stiffness leads
Two major changes with aging of the pulmonary sys to a decrease in the forced vital capacity in older indi
tem are decreased elastic recoil and stiffening of the viduals. Flow rates are also significantly lower in
women and African-Americans than in Caucasian
men at any age (Dempsey and Seals, 1995).
Respiratory muscle strength, as reflected by the abil
ity to create pressure over a range of lung volumes and
TABLE 36-2 flow rates, is similar when comparing healthy 30 and 70
Vascular and Autonomic Changes With Aging* year olds (Johnson and Dempsey, 1991) This suggests
that respiratory muscle strength does not change with
BECAUSE AFTER
OF AGING EXERCISE aging; however, maximal inspiratory and expiratory
TRAINING pressures have been reported to decrease 15% between
Arterial wall thickness i ? the sixth and eighth decades (Figure 36-4) (Enright,
Systolic blood pressure i t Kronmal, Manolio, Shanker, and Hyatt, 1994). Perhaps
Diastolic blood pressure i and H t these observed differences are similar to the differences
Orthostatic tolerance H ?
observed with submaximal and maximal cardiac re
Arterial and venous dilation t ?
sponses with the dynamic pressure measures over dif
Vasoconstriction H H
Copyrighted Material
36 The Aging Patient 675
monary capillary blood volume contribute to reduced mains unchanged as people age, although the vital ca
and uneven ventilation to perfusion matching in el pacity for elders is reduced. Likewise, as exercise and
ders. The resting partial arterial pressure of oxygen the tidal volume increase there is a slight drop in the
declines 5 to 10 mm Hg between ages 25 and 75 ratio of dead space to tidal volume. This drop is not
(Dempsey and Sea Is, 1995). These changes do not af effected by aging, although the older person will
fect the arterial oxymyoglobin saturation or oxygen breathe more (have a higher minute ventilation) in re
content. Paralleling changes in the peripheral vascu sponse to submaximal exercise.
lature, pulmonary vascular resistance and pulmonary The work of breathing is increased during exercise
arterial pressure at rest increase (Table 36-3). as people age as a result of a number of factors.
Higher ventilation during exercise requires the devel
opment of higher pleural pressures; thus increasing
Changes in Pulmonary Responses to
the work required. In addition, an increase in the end
Exercise With Aging
expiratory lung volume with increasing exercise re
In addition to the structural and functional changes at sults in breathing that occurs at a stiffer point in the
rest, a number of significant changes occur in breath lung-volume relationship. The increased stiffness im-
ing during acute exercise. Expiratory flow limitations
occur at lower exercise intensities as people age. A
normal, healthy 69 year old will begin to experience TABLE 36-3
flow limitations even in response to moderate exercise
Pulmonary Function Changes With Aging*
(Dempsey and Seals, 1995). Practically, this may be
experienced by the individual as having greater diffi BECAUSE AFTER
OF AGING EXERCISE
culty "catching his or her breath" during exercise. TRAINING
Normally as people exercise, the tidal volume in
Structure and Function
creases directly with increasing exercise intensity up
to about 50% to 60% of the vital capacity. This re Elastic recoil J,
Chest wall stiffness i
Alveolar-capillary surface area J,
Forced expiratory flow J,
MEP(cmHpl Total residual volume i
200
,--
lD.Women
Men Forced vital capacity J,
180 ,--
Maximum inspiratory and J,
160 r--
-
expiratory pressure
140 Ventilation-perfusion matching J,
120 Partial arterial pressure oxygen J,
100 Oxygen saturation H
80 Pulmonary vascular resistance i
60
Exercise response
40
Expiratory flow limitation i
20
Minute ventilation i
o f--�
65-69 70 - 74 75-79 80-84 Work of breathing i
Age Respiratory muscle oxygen i
consumption
FIGURE 36-4 Arterial hypoxemia H,i
Decrease in maximum expiratory pressures between ages Pulmonary artery pressure i
65 to 84 for both men and women. This is a measure of Pulmonary wedge pressure i
respiratory muscle strength. (Redrawn with permission
from Enright PL, Kronmal RA, Monlio TA, Schenker MB, 'i increases; J,
= = decreases; H = unchanged
Hyatt RE: Respiratory muscle strength in the elderly, Am J Tsubmaximal
Respir Cril Care Med 149:430-438, 1994.) t maximal
Copyrighted Material
676 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Cases
elastic recoil on the ventilatory mus diffusion and may contribute to ventilation
greater pressure development by the maldistribution ( Dempsey and 1995)
inspiratory muscles. The increase in expiratory flow
resistance likewise requires greater pressure
Effects of ExerCise Training on Pulmonary Function
ment by the muscles. Both the inspiratory
and changes increase the work of breath Aerobic training in elders can reduce some of the
ing. The increase in the work of breathing increases that have been described. There are limited or
the respiratory muscle oxygen consumption so that no studies that address some of the changes, such as
the muscles alone can 10% to chest wall or artery pressure.
12% of the total oxygen during The studies that are available deal with relatively
maximal exercise in a sedentary 70-year-old man young who are 60 to 70 years which does
)""W.N'" and (995). not insights into what exercise might do for
What is also apparent is that the reserves used to the those in their or beyond.
respond to exercise represent a greater percent of the Aerobic training can significantly decrease sub-
available capacity. An older individual can exceed
50% of inspiratory muscle capacity even during mod Jones,
erate exercise. This is in contrast to the younger indi program with women over a 12
vidual who exceeds 50% of the capacity with and demonstrated a 7.7% drop in the sub
exercise and 1 Thus the reserve maximal minute ventilation 36-5) et
capacity to pleural pressure is reduced in eI al., 1993). Decreased minute ventilation is accompa
ders v irtue of the fact that greater caoacitv is nied by a decrease in carbon dioxide production, the
needed even for moderate exercise. respiratory exchange ratio (carbon dioxide produc
The variability characteristic of exercise r e tion/oxygen consumption), and the blood lactate level
sponses in older individuals is particularly evident for any level of submaximal exercise (Makrides
when gas and et aI., 1986; Warren et aI., 1993). Thus the improved
cular hemodynamics. I n most individuals ventilatory after may have more to
demonstrate only slight in arterial blood-gas do with improved in the rather
but a small number of individuals than an on the pulmonary system Im
d e m on s t r a t e a r t e r i a l h y p o x e m i a w i t h e x e r c i s e proved metabolical efficiency results in the
and 1995). Some studies suggest production of less carbon dioxide; therefore the
that this response may be a factor of fitness level. do not have to work as hard to eliminate the carbon
More fit older individuals showed progressive arter dioxide. The important functional results of these
ial and carbon dioxide retention during changes are that the older adults will less
mild-to-moderate exercise (Prefaut, Anselme, Cail experience a lower perceived exertion,
laud, and Masse-Biron, 1994; et aI., 1994). and use a lower of their maximal ventila
The pulmonary artery pressure is increased with tory capacity during exercise (Jones,
at any oxygen consumption or cardiac output Exercise training also increases maximal ventila-
during exercise (Reeves, and \989). maximal exercise et
In addition, the maximal pulmonary artery pressure at 12-week pro
maximal exercise is reached at substantially lower oxy gram referred to above increased maximum minute
gen consumption and cardiac output in older individu ventilation 14% in women Figure
als with younger persons. The pulmonary 36-5) (Jo n e s, I . These w o me n walked 5
pressure also increases with age and can exceed s/week at an of 78% of the maximal
25 mm Hg peak supine exercise (Dempsey and treadmill heart rate or 118 beats/minute on average,
Seals, I Limited data suggest that these pres so the program was not very strenuous but IJH;'UWc.C'u
sures may in tum induce pulmonary edema during in substantial in maximum ventilation. Exercise
tense exercise in elders. Pulmonary edema would limit training can improve submaximal ventilatorv effi
Copyrighted Material
36 The Aging Patient 677
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The Patient with Neuromuscular or
Musculoskeletal Dysfunction
Mary Massery
INTRODUCTION
muscular and/or musculoskeletal deficits and what
It is often observed in a rehabilitation setting that clinicians can do to minimize or eliminate these
patients with neurological deficits continue to ac complications. The focus of this treatment approach
quire respiratory problems long after their acute is primarily aimed at the physical therapist (PT).
phases have subsided. Research has repeatedly doc Every effort is made to explain specific physical
umented a decrease in pulmonary function for the therapy concepts so that all clinicians, occupational
chronic neurologically impaired patient, yet many therapists (OTs), speech language pathologists
therapists do not appear to fully comprehend why (SLPs), respiratory therapists (RTs), and nurses
this occurs. This section tries to elaborate the causes (RNs), family members, and others can benefit from
of respiratory complications secondary to neuro the ideas presented in this chapter.
679
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680 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
DIAGNOSES ADDRESSED
ing may respond better to techniques that act primarily
The following treatment ideas are applicable for all on the subconscious and require little cognitive partici
neurological and orthopedic diagnoses including the pation. Finally, the differcnce between rehabilitation
following: spinal cord injuries (SCI), head traumas, and habilitation must be understood. Rehabilitation in
cerebral vascular accidents (CV A), multiple sclerosis volves restoring function, and habilitation teaches
(MS), amyotrophic lateral sclerosis (ALS), Parkinson's functioning for the first time. Children with acquired
disease, cerebral palsy (CP), muscular dystrophy (MD), deficits in utero or shortly after birth have never expe
polio myelitis (polio), spina bifida, and neuropathies as rienced normal movement patterns. Therefore they
well as back, neck, and shoulder injuries or dysfunc cannot depend on the memory of past motor experi
tion. However, it is by no means an exhaustive list. The ences to help con'ect abnormal motor patterns the way
primary consideration for application of these treatment adults going through rehabilitation can. This important
techniques is the residual physical deficits left by a neu difference must be accounted for when developing
rological or musculoskeletal insult. Therefore a patient their treatment programs.
presenting with hemiplegia will be treated with tech
niques geared toward promoting increased function on
PLANES OF VENTILATION
the involved side, regardless of how the original deficit
was acquired (e.g., from a CVA, head trauma, or CP). This neuromuscular/musculoskeletal treatment ap
Likewise, tetraplegia or paraplegia not only refers to proach is based on the premise that ventilation does
patients that have suffered from SCls but any patient not take place in a one-dimensional plane but rather as
that presents with tetraplegic or paraplegic deficits. a three-dimensional activity. The chest expands in an
However, three aspects of neurological/muscu anterior-posterior plane, an inferior-superior plane, and
loskeletal disorders must be clarified here to assist the a lateral plane (Figure 37-1). Too often, therapists treat
therapist in discerning which techniques, described patients with neuromuscular and/or musculoskeletal
later, are appropriate for his or her particular patient. dysfunctions with apparent disregard for this ex
The three aspects follows: (1) progressive vs. nonpro tremely important fact. This one-dimensional fallacy
gressive injuries, (2) cerebral vs. noncerebral injuries, has been perpetrated by techniques taught to new ther
and (3) rehabilitation vs. habilitation. Single-insult in apists that describe the patient's breathing program in
juries, such as SCTs, traumatic brain injuries, CVAs, only one or two postures, most often supine and sit
CPs, or cervical whiplash, are nonprogressive. The ting. To be effective, we must acknowledge this three
damage was only inflicted once and does not repeat it dimensional movement of the thorax and use this con
self. Progressive diseases, on the other hand, such as cept when determining treatment protocol.
MS, ALS, Parkinson's disease, MD, or scoliosis, show
increasing physical deficits over time. Goals for these
EFFECTS OF GRAVITY
groups will be different, with maximal respiratory
functioning stressed for the single-insult diagnoses and If chest expansion takes place in three planes, the ef
comfort and ease of ventilation stressed for progres fect of gravity on these planes must be considered.
sive diagnoses. Similar treatment consideration is Physical therapists would not exercise a weak muscle
given for patients with detrimentally affected cerebral without taking into account the effect of gravitational
functioning, such as with traumatic brain injuries, pull on that muscle, tbereby making the positioning
CVAs, and Parkinson's disease, versus those whose of the limb in space an important consideration in
deficits are at the spinal level, such as with SCIs, neu treatment planning. This same consideration must be
ropathies, myopathies, and polio. Patients with only given for the weakened ventilatory muscles. Gravity
spinal involvement may respond favorably to complex can assist, resist, or have no effect on the movement
techniques and demonstrate better conscious carry of the chest wall, according to the chest's position in
over, whereas those with impaired cerebral function space. Consider weakened intercostal muscles. Plac
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37 TIle Patient with Neuromuscular or MuscuJoskeletal Dysfunction 681
••
up and over the intestines, the lateral fibers of the di
aphragm can now move more horizontally to reach
the central tendon, thereby significantly reducing ex
cursion in all three planes of expansion. This adverse
positioning may be so significant as to cause a nega
FIGURE 37-1 tive lower chest expansion on inspiration for patients
Planes of respiration (anterior-posterior, inferior-superior, with tetraplegia. Quantitatively, this may be seen as
and lateral). much as Y2- to I-inch decrease rather than increase in
overall lower chest expansion, measured at the
ing a patient with this deficit in a supine position for xiphoid process, when the patient proceeds from
initial treatment in his or her rehabilitation program maximal expiration to maximal inspiration.
and then asking the patient to "breathe up into your Since gravity causes the intestines to shift, the ef
hands" is asking the patient to attempt the most diffi fect on the diaphragm will be most dramatic in a
cult gravitational posture first (breathing into the an gravity-dependent position, such as sitting or stand
terior plane with gravity resisting the movement). It ing, rather than in a gravity-eliminated position, such
would seem more appropriate to start retraining tech as supine. Thus the imponance of providing the pa
. niques in a gravity-eliminated posture for anterior tient with an external abdominal wall support in these
chest expansion, such as side lying, or a gravity upright postures should be undeniably clear. Al
assisted posture, such as hands-knees, and then though not as effective as the abdominal muscles
progress to gravity-resisted postures, such as supine. themselves, abdominal supports help restore the nat
Gravity also affects the positioning of the in ural mechanical advantage of the diaphragm (see
testines under the diaphragm. In the normal, neuro Chapter 22).
logically intact person, this seems to have a minor ef In addition to changing muscle effectiveness,
fect on respiratory functioning. However, for many gravity also affects bony structures. Obviously, this
neurologically impaired persons with a marked loss affects a growing child more so than a fully devel
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682 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 37-2
Proper mechanical positioning of the diaphragm relative to the abdominal viscera. Note the high
dome shape of the diaphragm.
oped adult, but both will be affected. Bones grow ac plays an extremely crucial role in the skeletal devel
cording to stress laid on them, thus abnormal stresses opment of the chest in the newborn. Normal, neuro
produce abnormal bony developments. For persons logically intact infants move freely in and out of pos
with severe neurological deficits, gravity becomes the tures, such as prone, hands-knees, and standing, as
main force acting on the bones and joints, unopposed they progress developmentally, allowing gravity to
by normal muscle action. This can result in many alternately assist or resist the movements. Through
skeletal deformities, such as flattening or flaring o f this, the infant begins to strengthen and develop mus
the lower anterior rib cage, narrowing of the upper cle groups and learn to interact with the gravitational
chest, loss of normal spinal curves, and chest cavus force in his or her environment.
deformities. Prevention of these deformities, rather This combination of normal movement patterns in
than their cure, must be the aim of a good long-term a gravitational field, along with genetic predisposi
ventilatory program for the neurologically impaired. tion, accounts for the normal development of the
bones, muscles, and joints that comprise the chest
wall. Conversely, infants with severe neurological
GRAVITY: EFFECTS ON CHEST DEVELOPMENT
impairments do not have that same freedom of move
Thus far the effects of gravity on the planes of venti ment within their environments. This applies to chil
lation, muscle function, and bony changes in the dren with congenital deficits, such as CP or spina bi
adult have been discussed. This same force, gravity, fida, or for children who acquire deficits at an early
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37 The Patient with Neuromuscular or Musculoskeletal Dysfunction 683
FIGURE 37-3
Independent upright posturing in a patient with congenital quadriplegia. Note relationship of rib
cage and abdominal viscera.
developmental age, such as some CY As, head trau neck renders the upper accessory muscles nonfunc
mas, or SCIs. These children become subjugated to tional as a ventilatory muscle. The infant's arms are
the effects of gravity on their growing and develop held in flexion and adduction across the chest, signif
ing bodies because they are unable to independently icantly hampering lateral or anterior movement of the
counteract its constant presence. A variety of reasons chest wall. This all points to underdevelopment of the
may account for their inability to change their own upper chest region in the newborn. The infant, forced
positions in space:(I) muscle weakness, (2) tonal to be a diaphragmatic breather, shows greater devel
problems (e.g., spasticity or flaCCidity), (3) reflex opment of the lower chest and hence leads to the tri
dominance, (4) incoordination, or (5) a combination angular shaping of the rib cage.
of the above. Typically, these children spend signifi From 3 to 6 months of age, the infant begins to de
cantly more time in supine than in any other posture, velop more trun k extension tone, they spend more
which can lead to undesirable changes in the thorax. time in a prone on elbows position, and they begin to
Understanding the basic steps and principles in reach out into the environmenr with the upper extrem
normal chest development is essential for accurately ities. This facilitates development of the anterior
assessing abnormal chest deformities often seen in upper chest. Constant stretching helps to expand the
this physically challenged population. Initially, the anterior upper chest both anteriorly and laterally. An
newborn's chest is triangular in shape, narrow and increase in intercostal and pectoralis muscle strength
flat in the upper portion, and wider and more rounded improves the infant's ability to counteract the force of
in the lower portion (Figure 37-4). The infant's short gravity on the anterior upper chest in supine, leading
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684 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 37-4
Newborn chest configuration. Note triangular shape.
FIGURE 37-5
A and B, I O-month old infant chest configuration. Note shape of chest changes and angle of ribs.
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37 The Patient with Neuromuscular or Mu culoskeletal Dysfunction 685
to the development of a slight convex configuration of Children with severe neurological deficits often
the area and a more rectangular shaping of the thorax show a very different picture of chest development.
from a frontal plane. Frequently, they do not develop adequate upper
The next significant development occurs when extremity and neck muscle control (e.g., weak mus
the child begins to independently assume erect pos cles, tone problems, reflex dominance, or incoordina
tures (e.g., sitting, kneeling, or standing). Until this tion), causing their upper chests to retain the more
time, the ribs are aligned 'fairly horizontally, with primitive triangular, flattened shape. Inadequate mus
narrow intercostal spacing (see Figure 37-4). In fact cle control or chronically shortened neck muscles
the newborn's chest only comprises approximately also renders the accessory muscles less able to assist
one tbird of the total trunk cavity. As the child be if needed in ventilation. In some cases the child's di
gins to move up against the pull of gravity, the ribs aphragm remains so strong and unbalanced by the ab
rotate downward (more so in the lower ribs), creat dominal and intercostal muscles that it creates a
ing the sharper angle of the ribs as seen in the adult cavus deformity (pectus excuvatum) at the sternum
(Figures 37-5 and 37-6). This markedly elongates (Figure 37-7). This occurs when the intercostal mus
the rib cage until it eventually occupies more than cles are incapable of maintaining the anterior chest
half of the trunk cavity. A comparison of chest x wall's position against gravity and the abdominal
rays of newborns and adults, as well as pictures of muscles are weak or flaccid, thus not stabilizing the
infants, clearly shows these developmental trends lower borders of the thorax. This may also eventually
(see Figure 37-4 to 37-6). Development trends are cause an anterior flaring of the lower ribs.
summarized in Table 37-1. Most of these children with severe neuromuscular
FIGURE 37-6
Normal adult chest x-ray. Chest shape is rectangular, ribs angled downward, upper and lower chest
equally developed.
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686 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
impairments require significant assistance to maintain rectus abdominus, as seen in many children with spastic
an upright posture, therefore they spend more time in a tetraplegia CP, the chest will become flattened anteri
recumbent position. Thus the rib cage tends to show orly, yet flared laterally in the lower ribs (Figure 37-8).
less downward rotation and elongation than that of the These children are unable to stabilize the lower lateral
normally developing child. In some cases of prolonged borders of their rib cage and are unable to counteract
supine posturing combined with hyperactivity of the gravity's influence on the anterior chest wall move-
TABLE 37-1
Chest Infant Ad ul t
Size Occupies one third of the trunk cav ity Occupies greater than one half trunk cavity
Shape Triangular frontal plane Rectangular frontal plane
Circular anterior-posterior plane Elliptical anterior-posterior plane
Upper chest Narrow Wide
Flat apex Convex apex
Lower chest Circular Elliptical
Flared lower ribs Integrated with abdominals
Ribs Evenly horizontal Rotated downward; especially inferiorly
Intercostal spacing Narrow Wide
Limits movement of ribs Allows for individual movement of ribs
Diaphragm Adequate Adequate
Minimal dome shape Large dome shape, greater excursion
Accessory muscles Nonfunctional Functional
FIGURE 37-7
Pectus excavation deform i t y (secondary to spinal cord injury and resultant muscle imbalance).
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37 The Patient with Neuromuscular or Musculoskeletal Dysfunction 687
ments. Thus we see these adverse musculoskeletal occurs because of pressure gradients between the air
changes, which limits the breathing patterns options. outside the lungs and the air inside. These gradients
As long as the neurological deficits are present, are achieved through movements in the chest wall.
these children will never develop normally. However, Muscle contractions provide the power to move the
frequent position changes, inhibition of undesired chest wall. If these muscles do not overcome the ef
tone, facilitation of weakened chest muscles, promo fect of gravity because of weakness, paralysis, abnor
tion of preferred breathing patterns, and incorporation mal tone, or inadequate muscle control, the chest will
of ventilatory strategies with movement will stimu be unable to expand in all three planes of ventilation,
late normal chest development. Optimum respiratory thus limiting pulmonary function. Because of this im
function cannot be expected from a severely underde portant fact, all muscles originating or inserting into
veloped chest. the chest wall become "ventilatory muscler" The box
on p. 688 lists these muscles and how they affect chest
expansion and other specific respiratory function.
MUSCULAR AND TONAL INFLUENCES
They are listed in the following two distinct groups:
ON CHEST DEVELOPMENT
the primary muscles needed for normal ventilation
Adverse effects of gravity are counteracted by func (the triad of normal ventilation) and all other acces
tioning musculature. Recall that inspiration/expiration sory muscles of ventilation. Impairment to any of
these muscles may result in respiratory deficits.
Another factor that determines a muscle's effec
tiveness as a chest wall mover is neurological tone in
the muscle. Rigidity of movement, as seen in some
patients with head traumas and Parkinson's disease
will render the chest immobile, severely limiting its
ability to expand in any plane. Spasticity, more often
to a lesser degree than rigidity, can render the chest
immobile. Spasticity (i.e., SCI, CP, some head
trauma), is frequently activated by quick movement of
the affected muscle either actively or passively. A
quick activity like coughing may activate this abnor
mal tone and work against the patient as he or she
tries to produce an effective cough. The other extreme
of abnormal muscle tone is flaccidity or lack of any
muscular tone, as seen with some SCIs, CY As, and
MD. In this case the muscle is entirely unable to move
the chest wall or to counteract the effects of gravity.
Of the three types of abnormal tone, flaccidity is the
most adversely influenced by the effects of gravity.
At the same time, postural reflexes and their effect
on muscle tone must be considered. For instance, the
tonic labrinthyne reflex (TLR) increases extensor
tone when the person is supine and increases flexor
tone when that person is prone. For patients with CP,
for example, this reflex may stay a dominant force in
FIGURE 37-8 their motor control, interfering with their ability to
Musculoskdetal changes secondary to static positioning move freely in supine and prone positions. Because
and neurological deficit. of this, a child with CP with increased extensor tone
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688 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
Diaphragm
• Innervation-phrenic nerve-C3 to C5
Intercostals
• Innervation-Tl to T2
• Lateral and superior expansion in lower chest during both quiet and forceful inhalation. Anterior expan
sion occurs to a lesser degree.
• Anterior and superior expansion in upper chest, lateral expansion occurs to a lesser degree.
• Forceful exhalation-primarily medial and inferior compression in lower chest, posterior and inferior
compression in upper chest
Abdominals
• Innervation T6 to L I
Accessory muscles
Erector spinae
• Stabilizes thorax posteriorly to allow for normal anterior chest wall movement to occur
• Innervated at TI to S3
Pectoralis muscles
• Innervated C5 to TI
• Can be a substitute rib cage stabilizer after paralysis of the intercostal muscles
Serratus anterior
• Provides posterior expansion of rib cage when upper extremities are fixated
• Innervated C5 to C7
• Only inspiratory muscle that is paired with trunk flexion movements rather than tnlllk extension mo.ements
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37 The Patient with Neuromuscular or Musculoskeletal Dysfullction 689
Scalenes
• Innervated C3 to C8
Sternocleidomastoid
Trape zi us
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690 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
Paraplegia: Primarily Tl to T5
• Abdominal
• Intercostal
• Erector spinae
3. Resulting in
Tetraplegia: C5 to C8
• Pectoralis
• Sen-atus anterior
• Scale·nes
3. Resulting in
Tetraplegia: C4
• SClllenes
• Di aphragl1l
3. Resulting in
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37 The Patient with Neuromuscular or Musculoskeletal Dysfunction 691
Tetraplegia: Cl to C3
I. Missing aforementioned muscles and weakened and/or absent, the last of the remaining accessory muscles
• Sternocleidomastoid (SCM)
• Trapezius
3. Resulting in
• Significant decrease in TV
• The need for full-time mechanical ventilation (at least in acute phase)
in the absence of the two other triad muscles, inter • lower chest collapses
costal muscles and abdominal muscles (e.g., polio, • upper chest rises excessively
tetraplegia, or paraplegia). Normal diaphragmatic ex • Diaphragm and upper accessory muscles only
cUl'sion requires the muscular support and function of (paralyzed intercostals)
the intercostal and abdominal muscles to optimize the • Upper accessory muscles only (all three "triad"
diaphragm's contractions. In this type of paradoxical muscles paralyzed)
breathing the diaphragm contracts, the abdomen rises • Asymmetrical breathers (hemiplegia, unilateral
excessively because of flaccid abdominal muscle disorders)
tone, and the upper chest collapses because of a lack • Lateral or "gravity eliminated" breathers (weak
of the stabilizing contraction of the intercostal mus ness not paralysis)
cles (Figure 37-9). This is the more common form of • Shallow breathers (typically associated with high
paradoxical breathing. tone)
The second type of paradoxical breathing occurs
when there is diaphragm paralysis while the upper
accessory muscles are still intact. The abdominal
muscles may or may not be functional. The see-saw primarily in a superior plane. Anterior and lateral ex
action here is the opposite motion of that described pansion may also occur if the intercostal and pec
previously (Figure 37-10). With this type of paradox toralis muscles are functioning. Generally, this com
ical breathing, the abdomen draws inward during in pensatory breathing pattern requires some kind of
spiration and the upper chest rises. The upper acces assisted ventilation, at least part time, because the di
sory muscles c o n t r a c t , exp a n d i n g the r i b c a g e aphragm normally supplies most of the expansion
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692 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 37-9
Paradoxical breathing, strong diaphragm, absent accessory muscles and abdominal muscles.
W((I'
FIGURE 37-10
Paradoxical breathing, diaphragm paralysis.
necessary to maintain adequate oxygenation levels. Another type of compensatory breathing pattern oc
Total accessory muscle breathing is generally inca curs when the intercostal and abdominal muscles are
pable of providing adequate independent long-term paralyzed but the diaphragm and upper accessory mus
ventilation because of the likelihood of respiratory cles still function (i.e., tetraplegia, Cs to Cs; and para
muscle fatigue. plegia, T I to T5). These patients learn to counterbal
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37 The Patient with Neuromuscular or Musculoskeletal Dysfunction 693
FIGURE 37-11
Shortened neck musculature secondary to accessory muscle breathing pattern.
ance the strength of the diaphragmatic pull by using Neurological insults that affect the chest asymmet
their sternocleidomastoid muscles and possibly their rically, such as with CV As and some head traumas,
scalene, trapezius, and pectoralis muscles. Allowing show another type of compensatory breathing pattern.
for superior and possibly some anterior and lateral ex These patients can still acti vely ex pand their unaf
pansion of the chest, this compensatory breathing pat fected side in all three planes of ventilation. Often,
tern prevents the collapse of the upper chest seen in they accentuate this asymmetry to achieve more ex
paradoxical breathing. This must be cognitively coor pansion on their unaffected sides. This may be seen
dinated with the inspiratory phase and is generally a as increased sidebending toward their involved side
more effective breathing pattern. On subjective breath (Figure 37-13). This leads to inadequate venti lation
ing assessment, these patients often present with short on the affected side, which puts these patients at a
ened neck muscles (Figure 37-11). Intercostal retrac higher risk of developing respiratory complications
tions, or the collapsing of the intercostal spaces on secondary to inadequate ventilation. In addition, the
inspiration, may be seen here. The paralyzed inter adverse effects on their posture can lead to undesired
costal muscle tissue will be sucked in toward the lungs musculoskeletal changes over a prolonged period of
during the creation of negative pressure within the time especially for the pediatric patient. Prevention of
chest, thus the observance of the retractions (Figure these secondary changes is of utmost importance.
37-12). This may be the most accurate way of assess Patients with generalized weakness, such as with
ing intercostal paralysis without an EMG test. Guillain-Barre syndrome, some myopathies, neu
If the patient lacks all "triad ventilatory muscles," ropathies, or incomplete SCls, may show a tendency to
they may be able to breathe using their upper acces ward lateral breathing, or breathing that takes place pri
sory muscles only. Generally they will need mechani marily in gravity-eliminated planes. For example, in
cal ventilation to augment their independent effort. supine, patients with weakened chest muscles could not
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694 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 37-12
FIGURE 37-13
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37 The Patient with Neuromuscular or Musculoskeletal Dysfunction 695
effectively oppose the force of gravity in the anterior disorder with oximeter)' during sleep. Patients show
plane, thus they alter their breathing pattern to cause ex ing deficiencies may need repositioning of their sleep
pansion in the lateral plane where gravity is eliminated. postures, nighttime ventilation, oxygen support, or a
In sitting, these same patients would tend to breathe in combination of these. Rigorous exercising or activities
feriorly where gravity would assist the movement. of daily living (ADL) training may be more appropri
Likewise, in side lying, they would tend to breathe in ately scheduled later in the day for these patients until
an anterior plane. Overall, these patients have the best their sleep problems have been rectified.
prognosis for effective breathing retraining methods be
cause they have weakness, not complete paralysis.
CHANGES IN PULMONARY FUNCTIONS
The last breathing pattern to be discussed involves
patients with central nervous system deficits resulting The abnormal breathing patterns discussed previously
in high tone, such as MS, Parkinson's disease, and develop secondary to the patient's neurological
some head traumas. Their breathing patterns are altered deficits. However, those new patterns then change the
not so much by muscle weakness as by the following: patient's pulmonary function, which in turn affects
(1) chest immobility because of abnolmally high neuro functional respiratory status. Specifically, changes in
muscular tone (spasticity, rigidity, tremors), which se respiratory rates (RR), tidal volume (TV), and vital
verely limits chest expansion in any plane, (2) cerebel capacity (VC) are addressed here.
lar incoordination, or (3) improper sequencing because Alveolar minute ventilation is the product of TV
of lesions in the brain, most commonly seen with times RR. The optimal relationship between these
medullary lesions. Breathing is usually symmetrical, two parameters is those values that result in minimiz
shallow, sometimes asynchronous, and frequently ing the mechanical work that the lungs must perform
tachypneic (respiratory rates over 25 breaths/minute). with a particular breathing pattern. In other words, it
Initiation and follow-through of a volitional maximal is the combination of RR and TV that requires the
inspiration is difficult or impossible for these patients. body to put out the least muscular effort per breath.
This will markedly curtail the ability to produce an ef Because most of the compensatory breathing patterns
fective cough and to maintain bronchial hygiene. that have been discussed thus far reduce the patient's
TV, the only recourse this patient has is to increase
RR. Normal RR is between 12 to 20 breaths/minute;
SLEEP DISORDERS
however, for this neurological population, it is not
The patients described in this chapter frequently uncommon to see RRs at least twice that figure.
need to use their accessory muscles cognitively, to ar Although adjusting RR does bring the patient's res
rive at a work-efficient, ventilation-efficient, breathing piratory system back to a state of equilibrium, it may
pattern. Because of this, they should be evaJuated for not produce the most efficient pattern in the long run.
nighttime ventilatory assistance. Muscle weakness or The idea of the oxygen cost of breathing in that pat
breathing inefficiency may cause a state of chronic tern must be considered in its long-term functional
hypoventilation and/or sleep apnea episodes during use. Ideally, TV at rest should be about 10% of one's
sleep. Drowsiness, lack of concentration, disturbed actual Vc. At this level, the able-bodied person needs
sleep, and/or irritability are common complaints of less than 5% of the total oxygen available to the body
this s t ate. In the c l i n i c a l setting, we see m a n y to operate the respiratory mechanisms. When per
tetraplegic patients and other severely involved neuro forming a normaJ physical task or low-level exercise,
logical patients who are lethargic after awakening. this oxygen consumption rate increases slowly, never
Hospital staff may incorrectly label these patients as quite reaching a point where the oxygen cost of oper
lazy or uncooperative. It should be assessed whether ating the respirator), system outweighs the cost of per
this behavior is volitional or whether it is due to a forming the activity. However, for patients with im
state of chronic nighttime hypoxemia. Assessments paired chest functions, such as in this popUlation, the
can be made by screening high-risk patients for this total oxygen consumption level of the respiratory
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696 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
muscles at rest can be as much as 4 to 10 times that the work of breathing. If VC remains less than 60% of
amount. These patients may have TVIYC ratios that the predicted value, most research indicates that these
are already in the 33% to 67% range at rest, indicating patients will demonstrate inadequate coughs. Similarly,
inefficient breathing patterns, reduced VCs, inade a FEV 1 less than 60% indicates lack of sufficient power
quate respiratory reserves, or both. When they attempt behind the cough. When VC remains or decreases to
a mild exercise, they become quickly short of breath. only 25% to 30% of the predicted nonn, then ventila
They do not have adequate oxygen reserves to supply tion assistance usually becomes necessary.
the respiratory and the nonrespiratory muscles simul
taneously, thus severely limiting exercise tolerance.
ADVERSE MUSCULOSKELETAL CHANGES
Therefore although these patients may show adequate
maintenance of alveolar minute ventilation at rest, a Neuromuscular wea kness and the compensatory
mild increase in activity level may magnify respira breathing patterns may cause adverse musculoskele
tory insufficiencies. tal changes over a prolonged period of time. Previous
An adequate VC is imperative in restoring a pa discussion in this chapter revolved around the ad
tient's functional status. Without the ability to expand verse effects that gravity can play on the skeleton if
the chest maximally under his or her own muscle the body is unable to counteract its force. Pronounced
power, VC will decrease after a neurological insult. For deformities are more prevalent in children, of course;
example, studies show that tetraplegia resulting from however, both children and adults are effected. Sev
SCIs may reduce the patient's VC to 33% of the pre eral examples of specific changes are presented.
dicted value, increasing the TVIYC ratio to 30%. For A common musculoskeletal deformity secondary
SCIs, an adequate VC is generally considered to be to muscle weakness is seen as a flattened anterior
66% of the expected value. This would restore the c h e s t w all, as s e e n w i t h m a n y p a r a p legic and
TVIYC ratio to approximately 15%, thus decreasing tetraplegic patients. (Figure 37-14) For the patient
FIGURE 37-14
Musculoskeletal changes in adult chest secondary to spinal cord injury (SCi). Note flattening of the
anterior chest wall and narrowing of the upper chest.
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37 The Patient ith Neuromuscular or Musculoskeletal Dysfunction 697
with weak or paralyzed intercostal muscles, this t1at Anterior or lateral t1aring of the lower rib cage
tening often occurs because of prolonged supine posi may also be noted. This is usually a result of insuffi
tioning along with the significant resistance that ante cient abdominal strength, thus the lower ribs are not
rior chest expansion meets from gravity. stabilized and integrated into the abdominal area (see
Another common deformity is a pectus excuva Figure 37-8, p. 687). In upright, this is seen as a
tum at the base of the xiphoid process. Patients who marked delineation between the rib cage and abdom
have a strong diaphragm but no muscular support inal area in the mid-trunk region (see Figures 37-3,
from the intercostals and abdominal muscles may p. 683 and 37 -15).
develop this type of musculoskeletal deformity (see Upper chest ad verse m uscu loskeletal changes
Figure 37-7, p. 686). It can result from the di occur when the intercostal and/or other upper acces
aphragm pulling inward so hard that the sternum, sory muscles are impaired. The diaphragm is not po
without intercostal muscle support, cannot maintain sitioned to assist in expansion of this area. Therefore,
its neutral position. Over time, it caves in, resulting without those accessory muscles, the anterior wall of
in a permanent deformity. the upper chest wiII become flattened and appear
FIGURE 37-15
Independent upright posturing. Adult with tetraplegia. Kyphosis restricts chest movement for
respiration. Note folding at mid-trunk line.
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698 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
more narrow than that of the normal upper chest (see Proper elongation of the cervical spine cannot occur,
Figure 37-14, p. 696), resembling the more primitive resulting in skeletal changes to that area. Scoliosis,
triangular shaping of the chest seen in the newborn along with thoracic kyphosis, tends to be more pro
(see Figure 37-4, p. 684). nounced than in the adult.
Spinal curves are not spared deformities. In a
weakened, low-tone patient, scoliosis is common be
DECREASED COUGH EFFECTIVENESS
cause the patient cannot adequately maintain himself
or herself upright against gravity. Slowly, the spine With decreased chest expansion, the presence of
collapses on itself, seeking stability; therefore scolio compensatory breathing patterns, and the adverse
sis is developed. All types of patients with the neuro musculoskeletal changes, the patient's ability to
logical diagnoses discussed in this chapter are at risk cough will be drastically reduced. Vital capacity will
for developing scoliosis. The second possible spinal be impaired as will the ability to build up sufficient
change, a lumbar and thoracic kyphosis, can occur as intraabdominal pressure, especially for patients with
well because of the force of gravity on a mobile spine weakened, flaccid, or uncoordinated abdominal mus
and lack of paraspinal muscle support. Secondary to culature. For many patients with traumatic brain in
these kyphoses, many patients develop an excessive juries, Parkinson's disease, CP, and CVA, the inabil
cervical lordosis to maintain eye contact. In sitting ity to coordinate an effective cough will be
the patient hunches over his or her trunk, making eye significantly impaired. This inability may be due to
contact and head righting difficult (see Figures 37-3, cerebellar damage or to high neuromuscular tone
p. 683 and 37-15, p. 697). (spasticity, rigidity, tremors). Frequently, the quick
These spinal changes affect the functioning of the action required to produce an effective cough will be
respiratory system adversely. With a kyphotic thorax the same action that will trigger a sudden increase in
in an upright posture, expansion of the chest in all the abnormal neuromuscular tone. Objectively, when
three planes of ventilation will be impaired. The ribs the patient can not expel at .Ieast 60% of his or her ac
require a stable base from which to become properly tual vital capacity in 1 second (FEV d, he or she will
mobilized. A kyphotic, weak posterior support does often be incapable of producing an effective cough
not provide the necessary stability for optimal rib without some assistance or retraining.
mobility and function. Therefore proper elevation and
angulation of the ribs becomes impossible. This lim
MAINTAINING BRONCHIAL HYGIENE
its overall chest expansion and vital capacity.
Musculoskeletal changes in children must be ad All these changes in respiratory functioning lead to a
dressed. They are in a state of habilitation rather than decreased ability of the neurologically impaired pa
rehabilitation. Because of this, the neurological tient to independently maintain bronchial hygiene.
deficit affects their developing chests more severely. Complete expansion of the chest in all three planes
Their rib cages remain more triangular in shape, since of ventilation and in all postures is impaired, so the
the muscles of the upper chest never develop fully or ability to properly aerate all lung segments is im
normally. The ribs also remain more horizontal than paired. Thus the ability to perform independent
in the normal adult, probably because of less upright bronchial drainage will I ikewise be impaired. Ineffi
posturing and lack of intercostal and abdominal mus cient breathing patterns rl)ay cause them to remain in
cle contractions on the rib frames. Their necks and a state of chronic hypoventilation. Inability to pro
shoulders do not mature developmentally, often be duce an effective cough impairs the ability to clear
cause of overuse of the neck accessory muscles. This the lungs of secretions. Therefore most of these pa
leads to a permanent shortening of the neck strap tients will require some assistance, either physically
muscles, making the child appear to lack a cervical or through verbal instruction, to achieve adequate
area (see Figures 37-7, p. 686, and 37-8, p. 687). bronchial hygiene.
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37 TIle Patient with Neuromuscular or Musculoskeletal DysfWlction 699
IMPAIRED PHONATION
provided by the muscles of ventilation (Figure 37-16).
Aphasia, as a secondary impairment to neurological When the respiratory muscles are malfunctioning, as
deficits, is generally recognized by all members of the in the neurological diseases discussed, the patient's
medical team as a problem that necessitates speech ability to regulate the flow of air out of the lungs may
therapy. However, many persons with neurological be impaired. Good eccentric control of the inspiratory
impairments display serious deficits in communica muscles (the ability to slowly release these muscle
tion that remain untreated and the deficits remain un during exhalat ion) is needed to p r oduce normal
acknowledged. Primarily, that deficit is inadequate lengths of phonation. Otherwise, the air may be ex
breath support for phonation; in other words the pa pelled from the lungs too quickly because of the nat
tient's inability to control the force and duration of ex ural elastic recoil of the diaphragm, rendering that
halation for the purpose of phonation. Duration of volume of air useless for phonation. Therefore both a
phonation and voice intensity are regulated by a deli decrease in tidal volume and a decrease in eccentric
cate balance between airway resistance, provided by control of the respiratory muscles will lead to impair
the laryngeal muscles, and the force of exhalation, ments in functional speech.
FIGURE 37-16
Relationship of air flow and vocal folds.
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700 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
The average adult breathes at a ratio of 1:1 or 1:2 Airtlow out of the lungs should be as impOitant to
(inhalation time: e x h alation time) d u ring quiet clinicians as airflow into the lungs. An evaluation of
breathing. The average ratio during phonation be expiratory eccentric control is nccessary for all neu
comes I :5, with 8 to 10 syllables per breath being a rological patients regardless of diagnoses. All disci
comfortable speaking length. Clinically, many pa plines should incorporate a phonation facilitation pro
tients are seen to struggle with two- to thee-syllable gram into their rehabilitation program, especially for
phrases because of inadequate breath support. Often those patients who would otherwise not receive any
these same patients are not referred to speech therapy speech training.
for training because they are not diagnosed as having
a "speech" problem (e.g., many patients with SCIs,
GOALS OF A NEUROMUSCULAR OR
MDs, polio, or spina bifida). Optimally, these pa
MUSCULOSKELETAL RESPIRATORY PROGRAM
ticnts should be able to phonate (an "ah" or "oh"
sound) for at least I 0 to 12 seconds during a con In conclusion, the combination of secondary cfJ'ects
trolled expired vital capacity. Many of their voices that follow a neurological and/or musculoskeletal in
fade away after 3 to 4 seconds. Without the ability to sult are responsible for leaving the person with residual
communicate with normal speaking lengths and nor musculoskeletal or neuromuscular deficits at greater
mal voice intensities, these patients' successful reen risk for developing respiratory complications long
try into society's mainstream becomes significantly after their acute phases have subsided. The long-term
more difficult. goal of any respiratory rehabilitation program for these
Another misconception about these patients is that patients is obvious; reduce their risk for developing
they are mentally slow or retarded because they do these complications. First and foremost is the need to
not use all the proper figures of speech. In reality, increase or maintain chest expansion in all three planes
these patients may exclude figures of speech because of ventilation. Second, educating the patient and/or
of the extended time it takes them to communicate family in methods to maintain good bronchial hygiene
something. For them, it is more expedient to forego must be emphasized to prevent infections. Logically,
their inclusion. improving cough effectiveness will improve airway
A marked example of this was seen in our clinic. clearance. Next, increasing the patient's vital capacity
A 3-year-old girl who sustained a complete C4 to C5
spinal cord lesion at birth and had not received prior
rehabilitation was seen. On initial examination, her
Respiratory Rehabilitation Goals
speech was choppy, brief, and grammatically incor
rect. She rarely initiated conversation and her voice • lncrease or maintain chest expansion in all three
intensity was very low. It was suspected that she per pl anes of ventilation
haps suffered some anoxic brain damage to account • Educate the patient and/or family in methods for
for her developmentally delayed speech. After an in maintaining good bronchial hygiene
with a physical rehabilitation program, her speech • Inc r e a s e the patient's vital capacity and t idal
changed drastically. She spoke fluently, with 8 to 10 volume
Copyrighted Material
37 The Patient with Neuromuscular or Musculoskeletal Dysfunction 701
and tidal volume, where indicated, will help to im Aronson, A. (1985). Clinical voice disorders: An interdisciplinary
approach. (2nd ed.). New York, Thieme Inc.
prove aeration of the lungs. If necessary, reducing high
Ashw0l1h, B. & Hunter, A.R. (1971). Respiratory failure in myas
respiratory rates to improve pulmonary functions will
thenia gravis. Proc R SocLondon (Bioi) 64:489-90.
be a goal. Other goals include modifying inadequate Bach,J.R. (1991). New approaches in the rehabilitation of the trau
breathing patterns, which could mean increasing or de matic high level quadriplegic. Americal JOllm,,1 of Physical
creasing the use of accessory muscles to achieve maxi Medicine and Rehabilitation 70( I):1]-9.
Bach, J.R. (1995). Respiratory muscle aids for the prevention of
mal breathing efficiency, and improving eccentric con
pulmonary morbidity and mortali t y. Seminar.< in Neurology
trol of the diaphragm and other ventilatory muscles for
15( I):72-82.
improved phonation skills. These concepts lead us to Boehme, R. (1992). Assessment and treatment of the respi rato ry
realize the need for incorporating effective ventilatory system for b realhing, sOllnd production and trunk control.
strategies with all motor tasks. These goals are summa Teamtalk 2(4):2-8.
rized in the box on p. 700. When implementing this Borden, G., H a r ris, K. Speech Science Primer: Physiology,
Acoustics, and Perception of Speech, 2nd cd. Baltimore,
program, it is necessary to recall that the patient's res
Williams & Wilkens, 1984.
piratory needs do not exist in a vacuum. They must be Boughton, A., Ciesla, N. (1986). Physical therapy management of
able to apply what they learn from this program into the head i n juried patient in the intensive care unit. TOIJi('s in
all phases of their lives. Thus incorporation of these Acute Care Trauma Rehabilitation 1( 1) : 1-18.
Boyden, E. (1977). Development of the newborn lung. In hudson,
goals into ADL or mUltipurpose activities will yield
W.A. (Ed). Development and growlh oj the airways. New
the most successful results.
York: Marcel Dek.ker.
Braun,N.T. (1982). Force-length rela tionship of the normal human
diaphragm. Journal of Applied Physiologv 53:405-412.
REVIEW QUESTIONS Brown, J.e., Swank, S.M., Matta, J., & brras, D.M. (1984). Lare
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l. What differences are noted in patients suf
Journal of Pediatric Orthopedics 4(4):456-61.
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c h il d with acquired d e f i c its in u tero or pulmonary alveolar development i n late gestation and the peri
shortly after birth? natal period. In Hudson, W.A. (Ed). Development and grm4'lh
offhe airways. New York: Marcel Dekker. 399-418.
2. Which orthopedic and neurologic diagnoses
Cartwright, R.D. (1984) Effect of sleep position on sleep apnea
can be associated with cardiopulmonary dys
severity. Sleep 7(2): 110-14.
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DeTroyer, A., et al. (1985). Mechanics of intercostal space and ac Kerby, G.R., Mayer, L.S., & Pingleton, S.K. (1987). Nocturnal
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DeVivo. MJ., Kartus, P.L., Stover, S.L., Fine, P.R. (1990). Bene Levitt, S" & Miller, C (1973), The interrelationship of speech
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Copyrighted Material
The Transplant Patient
Susan Scherer
HISTORY BACKGROUND
The ability to transplant an organ from one individual Early transplant experiments were carried out on ani
to another is a relatively new phenomenon. Early at mals in the early 1900s, with success at maintaining
tempts at transplant were barely successful. New ad life for 90 minutes to 8 days (Hosenpud, Cobanoglo
vances in surgical techniques and immunosuppres Norman, Starr, 1 991). Medical advances in car
sive drugs, however, have made transplantation of diopulmonary bypass and immunosuppressive med
solid organs a viable treatment option. The increased ications provided the opportunity for successful
life expectancy of transplant patients means that transplants. After many trials and failures, the first
physical therapists have many opportunities to treat successful orthotopic heart transplant was performed
patients after transplant in various settings. Trends in in 1967 by Barnard; the first successful lung trans
patient demographics indicate that a physical thera plant was performed in 1963 by Hardy and Webb.
pist may see a transplant patient not only in a re Improvements in surgical technique, detection of
gional medical center setting but also in outpatient rejection, and immunosuppressive drugs means trans
and rural clinics. This chapter contains guidelines for plants are increasing in number. Virtually every solid
treating patients with heart or lung transplants. organ can be transplanted from one individual to an
703
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704 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
other of the same species if there are similarities in National I-year survival rates are as follows:*
immune system markers. Kidney transplants are the
simplest and most common, whereas heart-lung block Kidney 93 8%
.
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38 The Transplant Patient 705
tient with cystic fibrosis receive a double-lung trans transplant program. Because of these needs, most
plant even though the donor lungs could go to two transplants are performed at large, regional medical
different individuals with pulmonary fibrosis? These centers, often those associated with a medical school.
are some of the ethical issues with which transplant Because donor organs are viable for only hours after
teams struggle. There are no easy answers nor is there removal from the donor, patients waiting for trans
unanimous agreement on each case. Despite the diffi plant are required to live within a several-hour radius
culty of making wise choices, each team carefully of the transplant center. Some patients may arrange
considers each candidate for transplant. Criteria are air transportation to the medical center, others may
used so that individual preferences of team members relocate themselves and family to temporary housing
are not given priority. When and if health-care re within the metropolitan area. Most patients are given
sources become more limited, the decisions may be a beeper to maintain contact in a timely manner.
come more difficult. If transplant success improves
and donor organs increase in number, transplants
Psychosocial Implications
could become a mainstream of treatment.
A strong support system is considered an essential
component of a successful transplant. Demands of
Criteria for Being listed on a Transplant Waiting list
waiting and relocation to the transplant city put con
Virtually every medical center with a transplant siderable stresses on the patient and significant others.
program has developed criteria for patient selec The patient is torn between wanting to remain hopeful
tion. Although each center may set its own criteria, that a transplant will provide new life and the reality
there are similarities among the medical centers of knowing that death may come before the transplant.
(see box below). Patients feel these oppositional forces continuously
and struggle to keep a balance between hope and real
ity. Therapists can assist patients by listening to feel
Waiting Time
ings, being supportive, and encouraging participation
The time spent waiting for a transplant can vary con in support groups. Because most patients experience
siderably. Some patients wait less than a week; others these feelings, support groups offer invaluable inter
wait up to 18 months. During the waiting period, pa vention. Groups which include patients both before
tients struggle with the need to carry on their lives, all and after transplant probably have the most to offcr in
the while knowing that at any moment they may be terms of psychosocial support. Those patients who re
called to the hospital for transplant. locate to transplant centers may have the most diffi
The number of transplant centers in the United cult time psychologically, especially as they leave
States is limited. State of the art hospital facilities and family and significant others behind. Feelings of
surgeons are neccssary components of a successful being useless are common because patients waiting in
a foreign city must find something to do.
Spouses and significant others also benefit from
group support. The psychological stresses are some
what different on spouses. Spouses speak of the
Criteria for Transplant Waiting List struggle to remain hopeful, yet plan for a future that
may not include their loved one. If the patient and
Age: under 65 (60 in some centers)
spouse move to a new city to wait for transplant, they
Terminal illness (expected life span less than I year
may find themselves with more time together than
Nonsmoker
they have ever spent before. ]n this forced retirement,
Adequate social support system new stresses are added to relationships. Transplant
Disease free in other systems teams usually include a psychologist or social worker
to whom patients may be referred for individual or
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706 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
family counseling if the stresses limit function or par fort and function after surgery. The physical therapist
ticipation in pretransplant programs. should be familiar with the surgical incisions and im
After transplant, patients struggle with conflicting pact on rehabilitation.
feelings. Patients are often emotionally overwhelmed Heart transplants are usually performed through a
with a feeling of gratefulness that they are alive and median sternotomy incision and cardiopulmonary by
feel guilty that someone else's glief has given them a pass is used. A midline incision from sternal notch
chance to rejoice. Psychological or spiritual support distally allows the sternum to be accessed and split.
may be requested or s u g gested after transplant Although the native heart is excised, a portion of the
(Craven, Bright, and Dear, 1990). right atrium and the SA node is preserved. The donor
heart is sutured to the atrial cuff and the major ves
sels reattached. After surgery, the two halves of the
Patient Education
sternum are wired together, the new heart defibril
The waiting period time provides an ideal opportu lated, bypass reversed, and the patient awakened.
nity for patient education. Nursing generally provides Lung transplantation surgical incisions depend on
much of the education regarding preoperative proce whether a single or double-lung transplant is to be
dures, postoperative course, and medication. Rehabil performed. Single lung transplants are performed
itation teaching includes breathing training, airway through a posterolateral thoracotomy incision, with
clearance techniques, and activity progression. the patient side lying on the opposite side. To allow
visual access for the surgeon, the latissimus dorsi and
lower trapezius muscles are cut. The incision through
TRENDS IN TRANSPLANT CARE
the fourth or fifth intercostal space also means the in
Transplants are being made available to a broader tercostal muscles at this level may be incised. If the
group of patients. Although transplants are only per rib at the surgical level fractures, it is resected so that
formed in certain centers, patients from rural areas the bone ends do not rub or puncture the lung. The
are being evaluated at regional centers. Because serratus anterior muscle is preserved if at all possible,
transplant criteria differ slightly from center to center, but the lateral portion of the rhomboid may be cut to
some patients may be evaluated at several centers. allow more access for the surgeon. Postoperative pain
The increased availability of transplants and the relia and impaired upper quarter movement patterns may
bility of air transportation means that even patients present significant problems for patients.
from outlying geographical areas may be considered Double-lung transplants are performed through an
for transplant. After transplant, improved medical anterior incision sometimes described as a clamshell
care has led to shorter hospital stays. For the patient approach. A horizontal incision above the level of the
who has relocated to the transplant city this means diaphragm is performed, but the distance needed for
that he may be discharged to an apartment and return adequate visualization means that the pectoralis
to the hospital several times a week for physician fol major and minor may be incised bilaterally.
low-up and rehabilitation. Once medically stable, pa
tients may be allowed to return to their homes as
PHYSICAL THERAPY CONSIDERATIONS
early as 2 to 3 months after transplant, if medical sup
port and rehabilitation needs can be met. As important members of the transplant team, physi
cal therapists need an understanding of the physiolog
ical components of both the pretranspJant disease and
SURGICAL PROCEDURES
posttransplant state, the influence of surgery or physi
The surgical approach for transplant is chosen to pro ology on musculoskeletal structure and function, and
vide the surgeon the optimal working area and visual how medical management may necessitate modifica
field. The choice of incision may affect patient com tion of therapeutic interventions.
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38 The Transplant Patient 707
Physiology
c1es of respiration is reduced. The physical therapist
The cardiovascular and respiratory systems are criti needs to optimize breathing in the preoperative pe
cal elements of functional ability, in areas of en riod, yet prepare the chest and shoulder muscu
durance and movement. Adequate oxygenation and loskeletal system for normal function.
circulation are needed to provide fuel to perform
daily activities. In the patient awaiting heart trans
Medical Management
plant, cardiac output is significantly compromised,
and hemodynamics may be unstable. Because of Knowledge of medical management including med
these limitations, pretransplant exercise is inappropri ications, ventilatory support, and hemodynamic mon
ate. Posttransplant. however. the main interventions itoring assists the therapist in determining whether
will be to restore normal cardiac output. Knowledge modifications are needed during rehabilitation. Table
of physiology allows the therapist to choose appropri 38-1 lists suggested areas to monitor during both be
ate interventions. fore and after transplant rehabilitation. For example,
In patients with terminal lung disease. the primary patients often complain of tremors during rest and ac
limitation is ventilation. Pulmonary rehabilitation has tivities. Therapists should be knowledgeable enough
been beneficial in improving daily function (Toronto to question other health professionals as to whether
Lung Transplant Group, 1988; Petty, 1980; Moser, the tremors are a result of medications, such as cy
Bokinsky. Savage, Archibald, Hansen, 1980) and c1osporine, a metabolic abnormality, a seizure disor
may be used in the pretransplant period. Supplemen der, or muscle weakness.
tal oxygen can be lIsed during exercise to maintain
adequate oxygenation. The waiting period before
PHYSICAL THERAPY ASSESSMENT
transplant is an ideal time to optimize muscle func
tion and flexibility. The purpose of physical therapy before transplant is
to identify baseline function and to screen for impair
ments that may limit rehabilitation goals. In some in
Musculoskeletal Considerations
stances, physical therapists will provide treatment in
The musculoskeletal problems of patients with pul the pretransplant period; in other cases, the informa
monary disease are well documented (see Chapter 4). tion gained from early assessment allows the thera
Patients undergoing lung transplants are unique in pist to identify areas needing attention or modifica
that after transplant the musculoskeletal system re tion after transplant. Physical therapy assessment in
turns to normal structure. The chest wall adapts in the postoperative period addresses specific impair
size to the new lung. The need to use accessory mus- ments and functional limitations of the individual.
TABLE 38-1
Recommended Monitoring
" = heart x = lung
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708 PART V[[ Guidelines for the Delivery of Cardiopulmonary Physical Therapy; Special Cases
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38 The Transplant Patient 709
Interventions
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710 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
Upper body
Lower body
Trunk
0% to 5% grade 10 to 30 minutes
Pulleys Theraband
Latissimus
Triceps
Subscapularis
Lower Extremity
Quadriceps
Hip extensors
Hip abductors
Stretching (full-body)
B reathing
Relaxation
ever, m a y be u s e d as appropriate (i.e., muscle and increasing functional abilities in self-care and
strengthening, range of motion). ambulation.
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38 The Transplant Patient 711
Physician DX MEDS
21CU -Active ROM, sit on edge of bed x 5 reps -Sit in chair as tol
1.5-2.0 METS -Teach Rating Perceived Exertion -Partial/complete self care
-Up in chair for meals
-Turn, cough, deep breathe and use
incentive spriometer, q2-4°
-Sitting bed bath
3 FLOOR -Active ROM/warmups, standing x IO reps -Sit in chair 2-3x/day (20 min)
2.0 METS -Walk 100 ft. slow pace -Complete self care
-Sitting bed bath
-Incentive spriometer indep, TID
-Exercise HR not more than 20 beats above rest -SBP < 200, DBP < 120 during exercise
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712 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
stiff for several days, and the sympathetic nervous the heart is denervated. Because of the lack of sym
system input to the heart is destroyed in the transplant pathetic input, heart rate cannot increasc quickly and
process. To maintain cardiac output (HR x SV) in a contracti I ity is not under sympathetic control. The
heart with decreased stroke volume a fixed rate pace only mechanism by which heart rate can be increased
m a k e r is u s e d at a r a t e of a p p r o x i m a t e l y 120 is by circulating catecholamines, which take 10 to 15
beats/minute for several days. ECG readings may be minutes to influence a response. Therapists working
normal because the donor heal1 has an intact conduc with heart transplant patients should allow time for
tion system, although the atrial cuff left from the na patients to adapt to changes in position and may want
tive heart may cause the ECG to have two P waves. to use light active bed exercises as a warm-up activity
The therapist working with heart transplant patients (Irwin and Tecklin, 1995 ).
in the ICU should be aware that heart rate cannot in
crease significantly, therefore blood pressure and pa Lung Transplant
tient response should be monitored. Surgical cardiac
rehabilitation guidelines can be used to guide treat Considerations
ment, with increases of 0.5 to I metabolic equivalent After lung transplantation, patients are generally me
(MET) per day (see box on p. 711). Complications of chanically ventilated for 24 to 72 hours. Often, para
heart transplant include sternum instability, infection lytic agents are lIsed in this period so that ventilation
or pain, and potential nerve or circulatory damage to can be optimized. Patients who received double-lung
the femoral area because of intraaortic balloon pump transplants may be more hemodynamically compro
(lABP) cardiac assist. Acute rejection episodes are mised if they were on bypass during surgery. Chest
characterized by flu-like symptoms including low tubes are likely in place, and patients are medicated
grade fever and muscle achiness and is often accom for pain. Infection control is imperative; isolation
panied by dysrhythmias. Rejection episodes can only rooms with negative-pressure ventilation are used
be confirmed by tissue biopsy. and medical personnel at minimum are required to
wash their hands and wear masks when in the pa
Goals
tient's room. Isolation or reverse-isolation procedures
Goals of the acute phase of rehabilitation include the are followed (the patient wears the mask when leav
following: (I) regain normal postural cardiovascular ing the room). The primary monitoring is oxygen sat
responses (no postural hypotension) and (2) increase uration, followed by heart rate and blood pressure. A
functional activities. The former is primarily focused common complication in the immediate postoperative
on the patient being able to tolerate changes in posi period is pneumothorax.
tion, increase time in upright sitting, and transfer in
dependently. Upper and lower extremity range of
Goals
motion and strength need to be adequate to perform In the immediate postoperative period the major goals
activities of daily living. are to increase time out of bed, optimize ventilation
perfusion ratio, and increase active range of motion on
Exercise Guidelines
the surgical side (Malen and Boychuck, 1989). Major
Deconditioning and lack of sympathetic input to in problems and goals are listed in Table 38-2.
crease heart rate response contribute to the possibility
of hypotension. Because of the high incidence of pos
Interventions
tural hypotension, patients need to change positions The range of therapeutic interventions are many. In
slowly and be given time to adapt to the new posi general an intervention may continue until an abnor
tion. Exercise may be continued during mild-to-mod m a l exercise response is reached. Abnormal re
erate rejection episodes but is not performed during sponses include a decrease in heart rate or blood pres
periods of severe rejection. The main consideration sure with an increase in exercise, a decrease in
for exercise in patients with heart transplants is that oxygen saturation below recommended levels (88%
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38 The Transplant Patient 713
TABLE 38-2
PROBLEM GOAL
Decreased secretion clearance Independent secretion management
Because the lungs are denervated, there is decreased
sensation of secret ions.
Considerations
to 90%), or symptoms of dizziness and diaphoresis.
Suggested treatments are shown in Table 38-3. As mentioned before, transplanted hearts lack auto
nomic innervation. Implications for exercise response
are that heart rate increases can only be accom
POSTOPERATIVE OUTPATIENT REHABILITATION plished, using circulating catecholamines. For the
phase II cardiac rehabilitation patient, this means that
Heart Transplant the warm-up and cool-down portions of exercise
Once the patient leaves the hospital, rehabi litation should be increased to 10 t o 15 minutes and pro
looks much like phase II cardiac rehabilitation. The gressed slowly. Resting heart rates are close to the in
overall objective is to increase functional activity to trinsic heart rate of 100, and heart rate should not be
within normal limits. used as an indication of fitness nor to establish exer
Duration of this phase of rehabilitation generally cise intensity. Rating of perceived exertion is a more
continues for 8 to 12 weeks, at which time the patient appropriate indication of exercise intensity. Recom
is encouraged to continue exercise on his or her own mended guidelines are 11 to 13 on the 20-point Borg
or at a fitness facility. Many heart transplant patients scale (Irwin and Tecklin, 1995; Hosenpud et aI.,
return to predisease levels at this stage. 1990). Both endurance and strength exercise can be
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714 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
TABLE 38-3
GOALS INTERVENTIONS
I
Independent secretion management Incentive spirometer I
Secretion removal (positioning, percussion, and vibration)
Assisted cough or instruction
Independent activities of daily living (dressing, Encourage and assist with activities of daily living
hygiene, shower, toilet) Active and active-assisted range of motion
Need adequate shoulder range of motion to All motions shoulder girdle
perform these activities Wand exercises
Side lying shoulder abduction
performed in this rehabilitation stage, although upper should be reported to the physician immediately. Re
extremity strengthening should only be started after jection episodes are monitored by biopsy. Exercise
the sternum has healed. To protect the sternum, lift can continue if the rejection episode is mild or mod
ing should be limited to Jess than 10 lbs for 6 to 8 erate as determined by biopsy. Summary guidelines
weeks. Treadmill, bike, arm ergometry, and indoor for postoperative rehabilitation for heart transplant
cross-country ski equipment are all appropriate are outlined in the box below.
choices.
The primary signs and symptoms of rejection include Because patients are discharged from the hospital as
flu-like symptoms including low-grade fever and early as 8 days after transplant, much of their medical
muscle aches. Dysrhythmias and bradycardia below management and rehabilitation occurs on an outpatient
60 or relative bradycardia (decreased compared with basis. In the early stages of this postoperative outpa
patient's normal resting heart rate) are significant and tient phase, patients are medically labile and need
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38 The Transplant Patient 715
Heart rate is not intens ity regulator same amount of activity is seen (Malen and Boy
chuck, 1989).
Increase warm-up and cool-down to 10 to 15 minutes
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716 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
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38 The Transplant Patient 717
Goals
Physical therapy assessment is critical to identify
problem areas and evaluate progress toward goals.
Goals at this stage should be primarily guided by spe
cific patient quality of life issues. Common long-term
impairments are chest wall soreness, abnormal upper
quarter movement patterns, and low back and knee
pain from overuse.
Prednisone
Because organ rejection is primarily an inflammatory
to return home to pursue his or her own interests. response, corticosteroids are usually used in trans
Success stories are many. One patient returned home plant patients. Steroid therapy may be delayed until
and progressed to walking 5 miles a day, fishing 4 to primary wound closure is certain (1 to 2 weeks) at
5 times/week, and bow hunting with a 50-lb bow. which time the patient is begun on low-dose oral
One gentleman reported at a 6-month follow-up visit steroids. Acute rejection episodes are treated with
that he was pleased to be riding around his ranch and oral or intravenous steroid pulses. Corticosteroids
checking up on things. The therapist asked if he was work by immobilizing macrophages and decreasing
riding in the truck, and he replied, "no, on my horse." B and T lymphocytes.
A 21-year-old male (130 Ib) with cystic fibrosis re
sumed weight lifting and bench pressed 1 JO Ibs, 8 Cyclosporine
months after a double-lung transplant (Figure 38-3). Cyclosporine is a very powelful immunosuppressive
Other patients have more rehabilitation needs. For agent that works by inhibiting T lymphocyte growth
example, a 40-year-old single-lung transplant patient factor and T helper cells. Side effects are common
sustained a brachial plexus injury from the surgery and annoying to patients. It is considered a peripheral
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718 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
ministration of these medications. The box above Craven, J.L., Bright, J., & Dear. C.L. (J991). Psychiatric, psy
chosocial, and rehabilitative aspects of lung transplantation.
summarizes the effects of common immunosup
Clinics Chesl Medicine, 1/(2),247-57.
pressive medications.
Hillegass, E., & Sadowsky. S.A. (1994). Essenlials of cardiopul
monary rei1.aiJilirarion. Philadelphia: WB Saunders.
Hosenpud, .I .D., Cobanoglll, A., et al. (199 I). Cardiac rral/splanra
SUMMARY
liol1. New York: Springer-Verlag.
Irwin, S., & Tecklin, 1.S. (1995). Cardiopulmol/ary physical rher
Physical therapy has an important role in maintaining
apy. St. Louis: Mosby.
and improving functional levels of patients both be
Malen, J.F., & Boychllck. J.E. (1989). Nursing perspectives on
fore and after organ transplant. Knowledge of cardio lung transplantation. Crilical Care Nursing Clinics of Norlh
vascular and pulmonary physiology along with the America, 1(4),707-722.
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38 The Transplant Patient 719
Moser, K.M., Bokinsky, G.E., et al. (1990). Results of a compre Toronto Lung Transplant Group. (1988). Experience with Singlc
hensive rehabilitation program: physiologic and functional ef lung transplantation for pulmonary fibrosis. lAMA, 259(15),
Archives of Intemal Medicine 140( 12): 1596-1601. Urliversill' Hospital surgical cardiac rehab ilitation proto col.
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The Patient in the Community
Donna Frownfelter
INTRODUCTION
This chapter focuses on patients in the skilled
Physical therapy in the community may take on a nursing home, home care, and alternative long-term
wide variety of forms. The practice has certainly care settings. These concepts and ideas could easily
changed dramatically over the last few years. Diag be used in an adult day care or outpatient setting,
nostic related groupings (DRGs) began the trend of senior housing, or a transitional or an assisted liv
patients leaving the hospital earlier and often in a ing facility. The settings described in this chapter
more acute stage of recovery. Subacute hospitals, will be used only as examples on which to focus the
Medicare skilled nursing, and rehabilitation facili discussion.
ties with transitional care units provide therapy and Continuity of care is an essential component of qual
facilitate patient progression so that he or she will ity health care in light of the trend toward earlier hospi
be back home within a short (perhaps a month) pe tal discharge either to a skilled nursing/rehabilitation fa
riod of time. Managed care has had a significant cility or to home with nursing and therapy support. A
impact on diagnoses and treatment authorization, colleague in hospital practice recently commented that
which affects the type of diagnosis given to patients she feels more like a triage therapist than a physical
and the number of therapy sessions authorized for therapist. At times the absolute basics of therapy (i.e.,
given diagnoses or symptoms. transfers and gait with an assistive device) are all that a
721
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722 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Thempy: Special Cases
patient is able to receive before leaving the hospital set live fuller and more salisfying lives even if they are
ting. An exercise sheet may accompany the patient unable to return home aCLcr rehabilitation. Many
home but, in general, after discharge from the hospital, nursing home chains have developed beautiful, hotel
most patients do not know their exercise programs. In like atmospheres with a range of services. The resi
addition, they have poor endurance because they are dents may live in independent apartments and, if a
generally still healing from the insults or injuries for disease or trauma occurs, may return to the skilled
which they were hospitalized. In the geriatric popula nursing area to receive rehabilitation services. When
tion the caregiver is often an elderly spouse who also they are able, they transfer to an assisted living area
has medical problems and is limited in the ability to as and continue to live there or will transfer back to
sist the patient. their apartments when they are sufficiently recovered.
The types and diagnoses of patients seen in the com Even after an acute incident (e.g., a cerebrovascu
munity may vary; often they are the very young and the lar accident [eV AD, a patient may not be able to re
very old. With the medical community's ability to save turn home in a month but may continue to make
premature, low-birth-weight infants we have had an in gains up to a year or more as strength, balance, and
flux of ventilator-assisted, oxygen-dependent infants endurance improve. Therapists can screen residents
with bronchopulmonary dysplasia (BPD). They may be and continue to try to improve their physical status
slow to develop and need intervention to prevent pul and to enable them to live to their fullest capacity.
monary infections and to improve in the natural devel
opmental sequence. Often they may have difficulty
MANAGED CARE
swallowing, and nutritional issues may delay their
physical gains, as well as their speech and language, Managed care groups are having a significant impact
secondary to poor breath SUppOit. on placement and case management of individuals
Specialty hospitals have been developed to care for who are able to return home. We are seeing many pa
the medically fragile, ventilator-assisted (dependent) tients in home care 5 days a week with caregivers pre
patient who is not stable enough to be at home or sent around the clock. Significant cost savings may be
lacks the resources to be at home. Many patients, es noted compared with an extended hospitalization or
pecially children on ventilators whose parents can stay in a skilled nursing facility. Most managed care
provide some care and are assisted by nursing staff, companies are willing to listen to suggestions that
are coming home successfully on ventilators. They in save money and improve customer satisfaction.
tegrate into the community in school and recreation, When we think of these practice settings, it be
function well, and perceive a high quality of life. comes obvious that cardiopulmonary concerns are
Elderly patients will often try valiantly to remain highlighted. From the very young to the very old, pri
at home and independent, amazing the most seasoned mary and secondary cardiopulmonary issues are often
clinician with their inventiveness and family/friend the limiting factor in a patient's rehabilitation progress.
supports. Others will recognize that they no longer Before considering some specific differences in
are able to care for themselves and that the caregiver, community settings, we will look at the commonalities
who is often also elderly (often a frail spouse), cannot in the principles of exercise training and prescription.
continue in that role.
Nursing homes, long thought of as a place "to go
GENERAL PRINCIPLES OF EXERCISE
to die," have become centers of skilled nursing and
TRAINING AND PRESCRIPTION
rehabilitation. The trend is moving toward "transi
tional care units" where a patient will go for approxi
Specificity of Training
mately I month to gain strength and practice activi
ties of daily living, transfers, and gait and develop Exercise programs are ind i viduall y developed to
endurance that will allow them to return home. meet specific goals. To develop muscle strength, a
The focus of long-term care is to help residents high-resistance, low-repetition program (i.e., weight
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39 The Patient in the Community 723
lifting) is prescribed. To develop muscle endurance, a of resting. Even more troublesome were the results
low-resistance, high-repetition program (i.e., walk that it took 10 to 50 days for the values to return to
ing, treadmill) is prescribed. The benefits of exercise the level before resting (Saltin et aI., 1968).
depend on the targeted exercise. Strength training in In normal individuals who received ventilatory
creases muscle fibers (white) and endurance training muscle training followed by a month without train
increases the number of capillaries and mitochondrial ing, the subjects lost the achieved training effect
content (Celli, 1994). (Keens et aI., 1977).
It is noted that a weight lifter is usually not a long
term runner, and few runners are able to lift heavy
SPECIFIC CARDIOPULMONARY CONCERNS
arm weights. In developing exercise programs, we
IN THE COMMUNITY
must keep in mind the goals for the individual. Gen
erally, some form of both strength and endurance is Patients in nursing homes, alternative long-term care
desired. However, programs often focus on one or the and independent living facilities, and the home after
other, not both. disease or trauma often have several problems in
common. They may have decreased independence,
mobility level, strength, and endurance, as well as
Intensity and Duration of Training
poor posture, and are at risk for falls 'if:condary to
Both intensity and duration have significant conse poor balance and weakness. Often they are poorly
quences on the amount of training effect. Olympians nourished, either from lack of appetite or dysphagia
often train at maximal or near maximal levels to or as a result of depression brought on by their physi
achieve their "superstar" level of fitness. However, it cal limitations and feelings of being overwhelmed
has been noted that middle-aged, nonathletic individ with their situations. At times there is a sense of
uals benefit from lesser levels of exercise. Siegel et hopelessness and a feeling that things will not be the
a!. (1970) demonstrated that training sessions of 30 same again. This depression is especially common
minutes about three times a week significantly im when patients are placed in nursing homes when they
proved V021l1a, when the heart rate was raised over wanted to go home but realized they could not take
80% of predicted maximal heart rate. care of themselves or their families insisted on the
Casaburi et al. (1991) studied 19 COPD patients placement.
who could achieve either 50% or 80% of maximal Many patients have a preexisting cardiopulmonary
exercise (anaerobic threshold). They found that pa disease, such as asthma, emphysema, bronchitis,
tients who participated in the higher intensity training coronary artery disease, prior myocardial infarction,
program benefited more than the lower intensity hypertension, dysrhythmias, or congestive heart fail
training patients. However, significant training did ure. In addition to those diagnoses, they often have
occur in the lower intensity group (Casaburi, 1991). fractured hips, knee replacements, or CV A. The car
The number and length of treatments have a sig diopulmonary factors may in fact be the limiting con
nificant effect on endurance training. An intense pe sideration to the progress with therapy. These con
riod of care followed by a maintenance or managed cerns need to be dealt with so that the patient reaches
care period prevents the effects of stopping exercise his or her full rehabilitation potential.
training. Carry-over and maintenance is extremely
important (Make, 1991).
IF YOU CANNOT BREATHE YOU CANNOT FUNCTION
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724 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
stand transfers. Limited by severe shortness of breath, dentures fit or is he or she not eating or chewing
she could barely ambulate across the room with her food because of poor dentition or denture fit? Is he
pick-up walker. When observed using her bron or she aspirating? Does he or she have dysphagia?
chodilator metered-dose inhaler (MDI), she was • Is the patient sleeping? Many patients after
found to be using it improperly. After she was in surgery, trauma, or a CVA are left supine or in a
structed on how to use it properly, she used the bron side-lying position to sleep. They may not have
chodilator before transfer and gait and was like a dif ever slept in that position before. However, they
f e r e n t patient. She was able to coordinate h e r do not recognize that may be the reason they are
breathing pattern with control t o match her activity not sleeping. If the patient states he or she cannot
and her endurance was remarkably improved. sleep ask him or her about previous sleep posi
With these principles in mind, we can look at tions and try to work with the nursing aide staff
some of the considerations in nursing home and on positioning for sleep.
home health settings. • Follow-through of methods of working with
the patient should be consistent so as not to
confuse the patient. For example, breathing ex
lONG-TERM CARE FACILITIES
ercises in conjunction with activities should be
AND NURSING HOMES
consistent. If the patient is taught in therapy to
As mentioned previously, with the changes in health inspire when extending the trunk, that should
care, much rehabilitation is now taking place in transi be communicated to other caregivers and con
tional care units, Medicare skilled nursing homes, and sistently encouraged. If the goal is for the pa
assisted living facilities. tient to walk to meals, a coordinated effort
The following are special considerations when should be made to try to have the patient ac
working in a long-term care setting. complish this as a transition plan. For example,
• There are several layers of care from geriatric when the therapist talks with the aide and a
specialist nurse consultants to head nurses to care plan is established, the patient can start
general floor nurses to aides. walking to one meal or as far as he or she can
• Most patient care is given by aides. toward the dining room. When that is accom
• Communication and cooperation are the keys to plished, the goal will be to walk to two meals,
achieving patient goals and success. and so on. Then additional goals can be added
• Input and involvement of the patient and family or to walk to activities, social settings, out to the
significant others is essential in developing goals. car to meet the family, and other functional,
• Clear and achievable goals need to be devel appropriate goals.
oped and revisited as the patient progresses or • In-services to reinforce the therapy techniques and
regresses in therapy. Is the goal to transition to goals should be done individually and in formal
home, to assisted living, or to living at the classes. Classes are helpful, on a one time basis, to
nursing home? discuss and instruct on a particular topic. How
• Quality of life issues need to be taken into con ever, an ongoing one-on-one therapist/aide pa
sideration. How mobile is the patient? Is he or tient-specific mini-in-service is essential. The
she independent? Is he or she a morning person? classes need to be repeated on a regular basis for
When is therapy going to be most efficient time new staff and as a refresher for some aides who
wise? Will it conflict with his or her other inter have not used or practiced the techniques. The
ests and activities, which may give him or her aides may at first feel they are "too busy and un
moral support or act as a distractor and provide able to do the job," but you can convince them
real recreation? that it will be of benefit to dle aide, as well as the
• Nutritional concerns need to be taken seriously. Is patients. The patient will be able to do more and
the patient losing or gaining weight? Do his or her in the long run, the aide will have less work. In ad
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39 The Patient in the Community 725
dition, the family members will be pleased and re markable in their patient care follow-through for
gard the work of the aide more highly. This will therapy goals. Be on the look out for ways to
also benefit the nursing home because it will be praise and thank them in a sincere manner. They
known for its individualized, excellent patient will be more willing to help in the future.
care, which will make the director of nursing and • Sponsor open house times in the therapy depart
the administrator pleased. Most aides would like ment so that the staff come in and can see the ther
to do the best for their. patients and provide the apists. You can provide educational material for
best care they can render. the staff (and food). Welcome their input and sug
• Try to get other programs and nursing home ac gestions for patients who may benefit from ther
tivity groups to follow-through with therapeutic apy but are not on the physical therapy caseload.
goals. Talk with the activity department if pa • Prepare a bulletin board to show the accom
tients need extra encouragement or help with plishments of patients in pictures and descrip
oxygen to participate. If patients need to drink tion. We all love success stories and being part
more water for increased hydration, ask them to of the success. Show pictures of aides, as well as
remind the patient and provide water. therapists, helping the patients.
• As a therapist, be willing to pitch in and help • In addition to chart reviews and talking about pa
whenever you are able, even if it "isn't in your tients with the nurses, screen patients in the din
job description." Your willingness to be a ing rooms and activity sessions and walking in
team player will be noticed. If an aide is off the hall. The aides will be a terrific source of pa
sick and you are available at lunch and see tient referrals; they are with the patients more
there is a problem passing out trays, offer to than anyone else.
help. The next time you ask an aide for help
there will probably be more willingness. If
MONITORING CARDIOPULMONARY STATUS
there is a patient that is difficult to transfer,
IN THE LONG-TERM CARE FACILITY
offer to help in getting the patient up for phys
ical therapy. This will serve as both a teaching With the increase in patient acuity, it is more impor
opportunity and as a help to the aide. Look for tant than ever to monitor the patient's response to
ways of blending your therapy with the needs mobilization and exercise. Many long-lerm care and
of the nursing staff. subacute facilities are purchasing pulse oximctcrs and
• Give recognition to aides who have been re portable ECG monitors because they have more
FIGURE 39-1
Pulse oximeter.
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726 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
unstable patients (Figure 39-1). In addition, all thera oxygen in the arterial blood) or to relieve the myocar
pists should be competent in blood pressure monitor dial work, such as in a patient with a severe myocardial
ing and taking pulse rates; auscultation training is infarction or other cardiac dysfunction (see Chapters 4
highly recommended (see Chapter 14). and 27).
During the initial evaluation the vital signs and It is important to note that the arterial blood gas
oximetry should be taken. The readings should be is drawn at rest with no patient activity unless
taken at rest in a supine or semi-Fowler's position for specifically noted otherwise (such as an exercise
a baseline. Readings should then be taken in sitting test blood gas). Generally the Medicare guidelines
and standing positions. It is helpful to take the blood require that the patient has a P02 of 55 mm Hg
pressure on both arms to see if there is a difference in (Torr) to be placed on oxygen. This is on the steep
the readings. part of the oxyhemoglobin dissociation curve (see
When the patient begins treatment, vital signs and Chapter 3).
oximetry should be performed before and after the When the patient exercises he or she consumes
mobilization or gait activity. A normal exercise re more oxygen than at rest. Consequently if a patient
sponse would be that the blood pressure and pulse is on oxygen at rest and the P02 is 55 or 60 mm Hg
would increase in relation to the activity. An increase he or she may desaturate during exercise. This
of 20% to 30% might be expected and would be means that the red blood cell Hg will give up more
within normal limits. The time the vital signs take to oxygen to supply the exercising muscle. However,
return to normal (recovery time) should be within 5 it is enough oxygen for exercise and the patient will
to 10 minutes. experience i n c reased s h o r tness of b r eath, the
Many patients who are not considered cardiopul oximeter will note a drop below 90%, and the blood
monary patients have an abnormal response to exer pressure and heart rate may initially increase be
cise. If we are not observing and measuring objec cause of the stress and later drop as the heart cannot
tively, we will not know the cardiopulmonary response compensate for the decrease in oxygen level.
is abnormal, and deleterious effects may occur. The pulse oximetry reading of normals is 97.5%
An example of this was seen in a patient one oxygen saturation. It is clinically acceptable to main
month after a CV A. The patient was very fatigued tain oxygen saturation at 90% or above. This satura
and complained that his knees felt like they were tion corresponds with keeping the P02 generally at
going to buckle. This patient had been doing quite above 55 mm Hg. When the P02 drops below 55 mm
well and was not being monitored. However, after the Hg, a dramatic drop in oxygen saturation will occur
patient ex pressed the feeling of weakness the thera for a small drop in P02.
pist took the vital signs after the patient rested and If the nursing home does not have an oximeter, the
walked again. The blood pressure and heart rate durable medical equipment company that supplies the
dropped during the exercise. The doctor was in oxygen may be called and will bring an oximeter
formed and ordered a blood test that revealed the pa when they check the oxygen. However, any patient
tient did not have an appropriate blood level of digi on oxygen at rest should be tested for desaturation.
talis. The medication was increased and the patient Another option is to call the patient's doctor to re
improved. Had the therapist not checked the vital quest an increase in oxygen during exercise. For ex
signs and continued to push the patient, there could ample, a patient on I Llmin at rest can have a pre
have been serious consequences. scription written for I Llmin at rest and 2 or 3 I/min
during exercise. The increase in oxygen is no prob
lem as long as the oxygen is decreased back to the
SPECIAL MONITORING CONSIDERATIONS
resting amount as soon as the patient recovers back to
FOR PATIENTS ON OXYGEN
baseline. This is even true for carbon dioxide retain
Patients receiving oxygen therapy have usually been ers whose oxygen is carefully titrated to prevent tak
placed on oxygen because of hypoxemia (low levels of ing away the hypoxic drive to breathe.
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39 The Patient in the Community 727
Functional outcomes are key to documentation. As Home care takes the practice setting one step further
we evaluate patients and write care plans, we set from the hospital. Managed care is having major im
goals that are both short and long tenn. Each goal pacts on changes in this area of therapy and nursing
should be linked to functional outcomes that enable care. Cost effective yet excellent therapy is the goal
the patient to be more mobile, safe, as independent as of managed care. There is a great deal of creativity;
possible, and functional in. the care setting in which deals can be made if a provider group can demon
he or she lives. strate that the patient will benefit and a cost savings
Documentation needs to show progress toward to the managed care group will occur. We are seeing
the functional outcomes the therapist has developed coalitions form between' contract service therapy
with the patient. Goals should be attainable and real agencies, durable medical equipment companies,
istic. If there is poor or slow progress to a goal, there nursing agencies, and enteral feeding companies to
needs to be documentation and explanation in the provide "one-stop shopping" groups. The managed
notes of what has occurred and how the treatment care companies prefer to make one call that will pro
program will be modified or how the goals need to vide them with nursing service, therapists, and home
be changed. medical equipment, such as walkers, canes, tub seats,
When the functional outcomes have been met, the raised toilet seats, oxygen, IVs, and enteral feeding.
patient is reasscssed to see if they can accomplish more Home care involves not only seeing more acutely
or if the patient should
. ill patients but also seeing some interesting cardiopul
a maintenance program. A screening date should be set monary situations. For example, in working with
to check back and monitor the patient to ensure mainte major medical centers who perform transplant surgery
nance, improvement, or decline in condition. At times the therapist works with patients before and after heart
patients who have "plateaued" will improve and may and lung and other transplant surgeries. It has been
be picked up on a screening to request a doctor's order demonstrated that patients, even as seriously ill as pre
to have additional therapy with specific increased goals transplant patients, can improve their functional abili
defined. If a patient's condition has declined, the pa ties, strength, and endurance to be better candidates
tient can be reevaluated to see if the patient's former for surgery. Postoperative care is also improved when
status can be resumed or maintained. the patient is in better physical condition before
It shou ld be remembered that third party payors surgery. Other diagnoses are also being treated effec
are reading the notes to understand what the evalua tively before and after surgery. It makes sense to
tion and treatment plan for the patient is and how begin preoperative orthopedic consults to evaluate pa
the patient has progressed in meeting functional out tients and teach them the exercises they will be doing
comes. Because the patient is receiving long-term after surgery. In addition, any patient facing abdomi
therapy, the more therapy the patient needs, the nal or thoracic surgery could benefit from a preopera
more documentation is necessary to tell the story to tive visit if coming to the hospital presents difficulty.
the third party payor or the managed care group. A Consequently, therapists who never thought they
good quote to remember is, "If it wasn't written, it would be required to work with cardiopulmonary pa
wasn't done!" tients are needing to increase their knowledge bases to
In summary, every patient in a long-term facility treat these patients appropriately.
is a patient with cardiopulmonary concerns. The car In the home-care setting the therapist is alone with
diopulmonary system needs to be optimized for full supports through the nursing and home-care agencies.
rehabilitation to occur. Cooperation with the nurses However, in the home they usually must be prepared to
and aides, as well as special activities staff, is essen evaluate patients and their progress with very little su
tial for follow-through of treatment programs and pa pervision or consultation. In addition, they must be able
tient success. Teamwork is the key, and communica to handle emergencies and crisis situations. AU home
tion and documentation are vital. care therapists must have a basic CPR certification
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728 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
renewed annually. Policies and procedures dealing with friends, or a caretakers smokers? Signs need to be
how to handle emergencies, infection control, and posted to warn of danger of smoking and flames
safety are essential for any therapist in the home. around oxygen. Patients who are smokers need to
Therapists need to know how to obtain necessary have this reinforced very clearly.
information and equipment for the patient. They need Does the patient have stairs? I s the bedroom up
to be creative in adapting equipment and be innova stairs? Is there a first floor bathroom? If the bathroom
tive if the patient cannot afford to purchase medical is on the second floor can the patient get up the stairs
equipment. This is not the setting for new graduates, safely and in a timely manner, or does a commode on
but rather for the experienced therapists. the lower level seem more appropriate?
Is the bed the proper height? Are there handrails? I s
i t difficult for the patient to transfer into bed? Is a de
HOME SETTING
vice needed to help the patient transfer independently?
In the hospital or outpatient center the patient comes to The question of the bed arose with one home-care
your place of business. They come where you work. patients who had a fractured pelvis. When I first vis
With long-term care and home care, you go to work ited her, I asked how she had broken her pelvis and
where they live. A certain etiquette is required when she replied, "Hopping into bed." I questioned what
going into a patient's residence. Pennission needs to be she meant and she said, "I' JI show you." I followed
requested to enter the residence, alter their living space, her to her bedroom watching her gait with her walker.
put in grab bars, remove scatter rugs and telephone When we got to her bedroom, it was quickly noted
cords that are seen as a safety hazard, or rearrange that this very short patient had a very tall bed. The
rooms that you may consider too cluttered and unsafe. mattress was between her iliac Crest and waist when
The therapist must remember that this is the patient's she backed up to the bed. She stated, "I used to have a
home and must be tactful in the way recommendations stool that I climbed into bed on, but my son thought it
are made. The cluttered room may hold treasures that wasn't safe and took it away. Now I have to hop up
have been accumulated over a lifetime. They may sur into bed!" She had returned home to do the same ac
round themselves with items that are all they have left to tivity that had put her in the hospital with a fractured
remember. It may be true that a path needs to be made pelvis. Looking at the bed, I noted that there were 3-
for safe walker ambulation, but how this is communi inch rolling casters and a caster pad under the hed.
cated may make all the difference in developing good The son was called and the casters and pads removed.
rapport between a home-care therapist and the patient. The patient was quite pleased that the bed was 4
I nitially, an evaluation of the patient's home needs inches lower and she could transfer in quite easily.
to be made. What equipment do they have, is it in Is there family support or a caretaker if the patient
working order, do they know how to use it? Often a is not independent? If the spouse needs to work or go
patient borrows "grandpa's cane" and does not real out, how long can the patient be safely left alone?
ize that he or she is eight inches shorter than grandpa. Does the patient know how to obtain a caretaker? Are
Modifications may need to be made so that existing they able to financially afford the support?
equipment fits properly and is functional. Most home-care agencies have social worker sup
Safety is a primary consideration. Are there cords port to help patients discover resources available to
across the floor? Are scatter rugs loose or tacked down them. A physician's referral is needed and the service
with carpet tape? Can the patient pick up his or her foot is generally covered under Medicare.
sufficiently to walk over the scatter rug without trip
ping? Are there pieces of kitchen linoleum that have
COMMUNICATION AND CROSS REFERRALS
come up and might trip the patient? Are the kitchen
TO OTHER DISCIPLINES
chairs on rollers and the patient's balance poor?
Is the patient on oxygen and you discover that he It is essential that communication take place between
or she h a s a gas stove? Are the close relatives, the members of the home-care team. Communication
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39 The Patient in the Community 729
is difficult because everyone is on the road and travel and is having difficulty swallowing may benefit from
ing to patients' homes. Generally, pager numbers of speech and occupational therapists working on seating
therapists and nurses are exchanged and compliance systems and feeding. The interaction and communica
with answering pages is good. However, considera tion between therapists facilitates ideas for both thera
tion needs to be given to the realization that we do not pists, provides continuity and follow-through, and
like to be interrupted frequently when seeing patients. helps to optimize patient care.
Generally a system of timing the calls or pages is wel
comed. A 91 I can be placed after the page number to
MONITORING CARDIOPULMONARY
identify an urgent call if the call is very impOltant or
STATUS AT HOME
information needs to be given immediately.
Physical therapy is the most common therapy. How Cardiopulmonary status at home is similar to that in a
ever, at times another therapy will be indicated but not long-term care facility. However, at home there is not
made when the patient is discharged. When a patient usually an oximeter available. This is unfortunate, since
expresses a problem that could be handled better or many more patients are coming home on oxygen and
could provide increased service to a patient, a cross re ventilators. This trend should change and home-care
ferral should be made by calling the home-care agency therapists should have oximeters available for evaluation
or the patient's nurse case manager. Identify the prob of patient status and exercise desaturation. The durable
lem and why you feel the additional therapy is indi medical equipment company has oximeters and the ther
cated. The physician will be called and the order gener apist may reqnest an oximetry study done with a physi
ally obtained. It would then be helpful for the refelTing cian referral. It is helpful to make an appointment and
therapist to call the new therapist and update rum or her meet the therapist to see the results and to try to reenact
on the patient and reason for the referral. This commu the therapy to see if the patient de saturates with exercise.
nication should be documented to show the necessary The same blood pressure and pulse monitoring
communication between the therapists and nurses. should be done at rest on both arms and in sitting,
An example of this was seen in a patient that I re standing, and before and after exercise as mentioned
ceived a refelTal on for home care that had been on a previously in this chapter.
ventilator for a month in the hospital. She had been intu
bated, was very hoarse, and complained that she was
HOME OXYGEN
having trouble swallowing and eating. Liquids espe
cially were going down the wrong way. The home-care Home oxygen may be supplied by an oxygen concen
referral said that the patient had a swallowing study in trator, by tanks or as a liquid oxygen system (Figure
the hospital that demonstrated she was aspirating. A 39-2) (Chapter 41). One consistent problem that must
speech language pathologist had been working with her be dealt with in exercise with patients at home on oxy
on swallowing in the hospital. However, speech therapy gen is the incredibly long oxygen tubing needed to
had not been ordered at home. Nothing had changed on allow patients t o go to the bathroom, out to the
the day the patient had been discharged. Since the pa kitchen, and to the living room (Figure 39-3). Often 60
tient was still aspirating, a speech consult was requested. to 90 feet of tubing must be used. The question often
At times it is helpful to do a joint treatment session arises, "Does the patient get the right amount of oxy
with another discipline. This can be done to coordinate gen with such long tubing?" The answer is yes because
therapy and provide focus and continuity of goals. It the flow meter is a compensated one, which means it
will also lead to success for the patient. For example, a reads what really is occurring. If more tubing is added
physical therapist and a speech language therapist may and a lesser flow was occurring, the flow meter would
meet to focus on a patient with poor posture who lacks drop to indicate that had happened. Then it would be
breath support for phonation. Another patient who is readjusted to the proper liter flow as ordered.
having difficulty feeding because of trunk weakness It has been found that the portable oxygen systems,
and is sitting in flexion with a forward head and neck in particular the demand oxygen system, do not always
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730 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
·"1
••
jf r-;- .
--
--
f .
deliver the exact amount expected (Figure 39-4). It is • Be compliant with medications and health
necessary to use oximetry to determine whether the pa precautions.
tient has an appropriate oxygen saturation reading. • Learn preventative care (i.e., prevent pulmonary
Patients need to be taught either to coil the tubing or infections and not increase salt/water intake if
to develop a means to make sure that they do not trip on cardiac precautions or taking steroids).
over the tubing because it creates a safety hazard. • Learn ventilatory strategies to increase comfort
Some patients have more than one tank or concentrator and function (see Chapter 00).
in the home to prevent having long lengths of tubing. • Learn to monitor themselves for signs of im
pending trouble (i.e., increased shortness of
breath, swelling in ankles, productive cough,
THERAPEUTIC GOALS FOR HOME-CARE PATIENTS
change in mucus, decreased urine Olltput, or
WITH CARDIOPULMONARY DYSFUNCTION
rapid weight gain) (Figure 39-5).
To be independent at home, patients with cardiopul • Train to pace activity and use energy conserva
monary dysfunction need to: tion techniques and rest periods to accomplish
• Understand the dysfunction or disease. more with less stress.
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39 The Patient in the Community 731
FIGURE 39-4
FIGURE 39-5
with exercise.
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732 PART VII Guidelines for the Delivery of Cardiopulmonary Physical Therapy: Special Cases
FIGURE 39-6
Nasal CPAP unit.
• Maintain proper nutrition and hydration. tion are essential in the progress and maintenance of
• Develop a support network to help when needed patients at home. As health-care practitioners, we
and to check on the patient occasionally. offer helpful suggestions for modification of the pa
• Maintain walking program and general exercise tient's home environment and life style. However, we
to continue functional gains. cannot force a patient to comply or accept what we
Some patients may need noctural nasal continu have proposed. The patient in the home setting is in
ous positive airway pressure (CPAP) (Fig. 39-6). dependent in his or her judgments and activities. We
This may be ordered to treat sleep apnea or to rest need to respect that and at the same time provide our
the patient and assist with ventilation. A Bt-PAP experience and therapeutic judgment and expertise.
unit allows the patient to rest and let the machine as This setting is often the most rewarding a therapist
sist ventilation by providing pressure support on in can have, although at times it also may be the most
spiration and exhalation. Often at first, the patient frustrating. One thing is certain, if you ask a patient
may have difficulty adjusting to the nasal CPAP, but where they want to be, the answer sounds like,
in time, the patient will adapt to the assistance and "There's no place like home'"
feel it is beneficial.
REVIEW QUESTIONS
SUMMARY
I. What are some common problems patients in the
Education, self-monitoring, compliance to medica community have in common?
tion, reduction of risk factors, nutrition, and hydra 2. What role does a preexisting cardiopulmonary
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39 The Patient in the Community 733
condition play in a new diagnosis or trauma (e.g., Jackson, D.E., & Wilhoire, M.J. (1985). Home health physical
therapy, considerations for the provision of care. Clinical Mun
CV A, hip fracture)?
agement in Physical Therapy, 5: I O.
3. What are some uniques situations or concerns
May, B.1., ( 1 993 ) . Home health and rehabilitation, Conce pis of
about patient care being delivered in a nursing Ca re, Philadelphia. F.A. Davis.
home, assisted living center, home care? May, B.J. (1990). Principles of exercise for the elderly, In Ba5ma
4. What role can a physical therapist play in opti jian, J.V. & Wolf, S.L. (Eds.). (1990). Therapeutic exercise,
mizing the patient's care in the above settings? (5th ed.). Baltimore: Williams & Wilkins. 1990.
Pfau, J. (1989). Adull exe rc ise inslrllClion sheets: Home exercise
5. How can cardiopulmonary function be monitored
fo r rehabili/{llion therapy skill b uilders. Tucson.
outside the hospital? Polich, C. (1990). The provision of home health care services
6. What special considerations should be taken with through health maintenance organizations: Conflicting roles for
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PART VIII
Related Aspects of
Cardiopulmonary
Physical Therapy
Copyrighted Material
Body Mechanics-The Art of
Positioning and Moving Patients
Mary Massery
Donna Frownfelter
Upright
Upright
INTRODUCTION
who can move independently and assume any given
Body mechanics may be defined as the efficient use of position with ease. In this chapter, the principles of
one's body as a machine and a locomotive entity. In body positioning and moving dependent patients are
working with critically ill or chronically dependent pa discussed.
tients, it is essential that optimal body positioning is ac
complished to facilitate maximal ventilatory potential.
POSITIONING FOR OPTIMAL VENTILATION
Therapists and nurses attempting to position or move
dependent patients must understand and use proper Because of the three-dimensional nature of breathing,
body mechanics (Neil, 1959; Fuerst and Wolff, 1969). the therapist's goal is to facilitate chest excursion in
This is necessary to reduce stress and trauma and to all three planes of ventilation-anterior-posterior, su
promote success for both the patient and the nurse or perior-inferior, and lateral (Massery, 1994). This can
therapist. Positioning and moving dependent patients is be accomplished by improving the length-tension re
an art that is quite different than working with a patient lationships of the muscles used in inspiration (Crosbie
737
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738 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
and Myles; 1985; Kendall, 1993). Massery reasons Upper chest expansion can be increased by remov
that the success of proper positioning to enhance in ing pillows under the patient's head to increase tho
spiratory muscles will do the following: racic extension. This will increase the length-tension
I. Improve the length-tension relationship of the relationship of the neck accessory muscles (scalene
accessory ventilatory muscles involved in that and sternocleidomastoid muscles). Increased move
posture ment will be noted in the upper chest in a superior
2. Incorporate a passive stretch of the chest wall and anterior plane. Further anterior expansion can be
3. Use the natural coordination of the trunk-chest achieved by using a towel roll placed longitudinally
wall movement with inspiration and exhalation at the vertebral spine to open the anterior chest of a
patterns to maximize movement patient who tends toward excessive flexion of the
The following are some common improvements that trunk (Figure 40-1).
can be incorporated into normal positioning. If the patient needs some support under his or her
head to achieve a neutral chin tuck to protect his or her
swallowing ability, then a thin pillow or horizontal
Supine Position
towel roll under the occiput, may be used (Figure 40-2).
As mentioned in Chapter 37, all activity is performed External rotation of the shoulders with the scapula
in the field of gravity. Patients in a supine position in a neutral or retracted position will place the pec
may find breathing difficult because they must over toral is and intercostal muscles on stretch. This will
come gravity to move the chest wall with each improve lateral and anterior chest wall movement
breath. Using towel rolls or pillows to facilitate a bet (Kendall 1993). If a patient has full range of motion
ter position may significantly improve the patient's (ROM) and is comfortable with the arms placed over
opportunity for improved respiration. head or in full flexion/abduction/external rotation for
"
//
,'\
\
'.t
FIGURE 40-1
Placement of vertical towel roll.
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40 Body Mechanics-The Art of Positioning and Moving Patients 739
FIGURE 40-2
Increased openness of anterior chest wall with the vertical thoracic towel roll and the occipital
towel roll combined.
FIGURE 40-3
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740 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
Sidelying Position
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40 Body Mechanics-The Art of Positioning and Moving Patients 741
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742 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
supports are now available and widely accepted. factors, such as limited space (i.e., small hospital
They provide additional abdominal wall support. rooms), clothing, or degenerative knee joints.
Another current school of thought advocates lift The first consideration in body mechanics is the
ing with the lordotic lumbar curve intact. This is the need for maintenance of proper posture and balance
technique used by weight lifters. When these individ (body stability). Consideration should he paid to the
uals are questioned about backaches, they usually relationship between gravity, posture, and body sta
deny any problems. bility (Figure 40-6). It is commonly known that grav
The lifting technique may be modified by other itational force is always exerted in a vertical direction
toward the center of the emth. In addition, that point
in a patient or object at which all of its mass is cen
tered is called the (·crller or gravity (the point at
whieh the patient's maximum weight is concen
trated). In the standing position the human body's
I
Center of gravity close to one's own centcr of gravity as possible. This
allows maximal conccntration of onc's own energy
toward movement of the patient, with minimal stress
or injury to oneself. To help accomplish this, the bed
I
should be adjusted so the therapist or nurse can reach
the patient comfortably. Usually adjusting the bed to
one's hip level is adequate. This makes the patient
close to the therapist's center of gravity.
)
The majority of lifting should be done with the
legs (knees) and not by straining to lift with the arms
and back (Figure 40-7). Whenever there is a question
about one's ability to lift a patient alone, generally it
4
should not be done, and assistance should be obtained
(Rantz & Courtial, 1977).
Another point to consider is the base of support
while lifting. The base of support is defined as the
area between the feet that provides the body's stabil
- Base of support
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40 Body Mechanics-The Art of Positioning and Moving Patients 743
of gravity of an object and perpendicular to the sur places the center of gravity in the direction of
face on which the object (body) rests (see Figure 40- the weight being lifted. To conserve energy and
6). The closer the line of gravity passes to the center maintain stability, carry the weight as close to
of the base of support, the greater the body's (ob your own center of gravity as possible. Lower
ject's) stability. Increased muscular effort needs to be your hips to the level of the surface supporting
exerted in proportion to the distance the line of gravity the weight you plan to lift by flexing your hips
shifts away from the base of support (Rauch, 1971). and knees. Adjust the bed up as high or down
To summarize and apply these concepts, one can as low as you need for comfortable and effi
list the following guidelines: cient work.
1. The lower the center of gravity, the wider the 3. The effort to petform a given activity depends on
base of support, and the nearer the line of grav the weight of the object to be lifted. Know your
ity falls to the center of the base of support, the limits. Do not attempt to lift alone if YOLl have
greater the body's (object's) stability. When any doubts about your ability to do so. Don't be a
lifting, stand with feet well apart, knees slightly hero in a back brace. Obtain assistance for the
tlexed, and one foot forward. Keep head and sake of both the patient and yourself.
trunk in proper alignment. 4. Other general tips for lifting are as follows
2. When our bodies are used as machines, the ex (Figure 40-7):
ternal weight on which we are working dis- • Lift with your legs. Keep legs in a position
that permits them to supply most of the force
for shifting your trunk.
• Do not attempt to lift with your arms and back.
• W hen lifting, avoid rotation of the spine.
Shift feet into position for weight shift when
moving or lifting patient.
• Stabilize your body against a stationary ob
ject whenever possible.
• For best efficiency, coordinate the move by a
synchronized verbal expression understood
by therapists and patient, such as "1-2-3 lift."
One additional consideration mLlst be noted
moving against the resistance of friction. Friction is
defined as a force that opposes the movement of one
object over the SUlface of another. Friction is reduced
as the amount of surface area contact between two
objects is reduced.
W hen moving a patient side to side or up and
down in bed, the therapist or nurse attempts to reduce
the contact of the patient's body sutface with the bed.
This can be accomplished by several maneuvers
use a turning sheet (placed just above the patient's
shoulders to just below the patient's hips), cross the
patient's arms over the chest or abdomen, flex the pa
FIGURE 40-7
Reach work level by bending the knees and hips rather than tient's knees and hips, and ask the patient to flex his
the back. Lift with the legs! This can also be done with a or her neck and raise the head as he or she is lifted (if
full double knee squat similar to techniques by the patient is unable to do this, the therapist or nurse
weightl ifters. will assist) (Figure 40-8).
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744 PART VIII Related Aspects of Cardiopulmonary Physical Thel'apy
GIfJ "\
FIGURE 40-9
To insert the drawsheet, the patient is tumed to
his side and the half-rolled drawsheet is tucked
under him (from just above the shoulders to
just below the hips). He rolls over the
drawsheet and it is pulled out behind him.
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40 Body Mechanics-The Art of Positioning and Moving Patients 745
FIGURE 40-10
The drawsheet should be rolled close to the patient's body.
A flexion hand grip at the patient's shoulders and hip is
most efficient.
FIGURE 40-11
Moving the patient toward the head of the bed. The patient
is prepared. The therapist is positioned to move toward the
II. Moving the patient to the side of the bed. head of the bed in order to shift his body weight to move
A. With turning sheet. the patient.
I. Cross arms, and other body parts, toward
the side to w hich the patient is to be
moved.
2. Therapist's hands at patient's hips and
shoulder on material close to patient's
body. 2. Bring right arm to the side at a 90-degree
3. One therapist pushes, the other pulls. angle up and away from body.
B. Without turning sheet. 3. Place left arm across chest.
I. Both persons stand on the desired side. 4. Place left leg over right leg.
2. One therapist's forearms under patient's 5. Pull sheet at patient's back to turn.
shoulder, the others under patient's hips. B. Without turning sheet (to right side).
3. Synchronize action by counting "1-2-3 I. Move to opposite side (therapist's hands
pull." and forearms under patient's shoulders
III. Turning the patient to his side. and hips).
A. With turning sheet (to right side) (Figures 40- 2. Same steps as 2, 3, and 4 above.
12 and 40-13). 3. Roll to right side using left shoulder and
l. Move patient supine to opposite side of left hip to push or pull.
turn (e.g., if turning to right side, move IV. Turning the patient prone (e.g., roll to right side)
patient to left side of bed). (Figure 40-14).
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746 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
'� ------ J
FIGURE 40-12
Preparation for the patient to turn to his left side: move
patient to the right side of the bed, position his left arm up
to the side at a 90-degree angle, cross the right leg and arm
over his body and turn the patient's head to the left.
FIGURE 40-13
A one-person turn to the right side using a drawsheet. The
patient's body position is the same as for the turn to the side. k!-
The therapist is positioned with one foot forward, the other
back. He pulls the sheet with his hands positioned at the hips
"@:: -
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40 Body Mechanics-The Art of Positioning and Moving Patients 747
REVIEW QUESTIONS
Positioning pa tient prone (EXM"IPLE: Rolling to the right 3. How can therapist use towel rolls and easily ac
side). The patient's right arm is tucked in at his side with cessible equipment to improve a patient's posi
the left arm and leg crossed ove r. tion and potential for improved ventilation?
4. What ventilation/perfusion changes occur when a
patient is turned from the "bad" side down to the
"good" side down?
S. Can positioning alone be considered therapeutic
A. With or without turning sheet. when it accomplishes the plan of treatment goal?
6. May want pillow under hips and lower Fuerst, E., & Wolff, L. (J 959). Fundamel1lals of nursing (4th ed)
Philadelphia: 18 Lippincott.
legs to bend knee and relieve back strain
[s there a right way to lift') ([985). Physical Therapy Forum, 4, 23.
at lumbar spine.
Johnson, G. (1989). Functional Orlhopedics I. San Ansellmo,
To summarize, we find patient positioning and Calif: Institute of Physical Art. Chicago: Course presentation
movement is a necessary and integral function of June 8-11,1989.
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748 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
Kendall, FP., McCreary, E.K., & Provance. P.G. (1993). Muscles Rantz. M. & Comiial, D. Lijiing, moving and Iransferring
lesling am/ flUlellOll. Baltimore: Williams & Wilkins. paliellls: a manual, S . . Louis, Mosby.
Lewis. L (1976). FUlldamellfai skills in patient care Philadelphia:
. Rauch, B. (J 971 L Kinesiology alld app/red allatomy, Philadelphia:
JB LippincotL Lea & Febiger.
Masscry. M. (1994). What's positioning got to do with it? Neuml Roper, N. (1973). Principles of (2nd ed). New
Report, /8 (3). 11-14. Churchill Livingstone.
Neil, C. (1959). Body management in nursing. Nursing Times, Woodhall-McNeal, A. P. (19')2). Changes 1I1 posture and balance
55,163. with age, Aging, 4 (3), 219-225.
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Respiratory Care Practice Review
Proper care of the pulmonary patient involves a multi The atmosphere around us contains 20.95°/'1 oxygen,
disciplinary approach, and all professionals involved one of the most essential elements needed to sustain
should have a working knowledge of each individual human life. Oxygen exerts a partial pressure of 159.6
profession's scope of care. As respiratory therapists, mm Hg at sea level (dry air) and approximately 97
physical therapists, occupational therapists, and nurses mm Hg in arterial blood. The normal range as mea
apply their expertise in providing care for pulmonary sured by arterial blood gas analysis is 80 to 100 mm
patienls, it becomes ev ident that coordi nated team Hg. Under normal circumstances, this molecule trav
work is essential 10 ensure errective treatment pro els from the atmosphere to the mitochondria at the
gramming. The purpose of this chapter is to provide cellular level where it is used to produce ATP in a
nonrespiratory therapist health-care professionals with process called aerobic metabolism. The pathway in
an overview of respiratory care principles and modali volves the lungs, blood, circulation, and the muscle
ties frequently encountered in the various settings. It tissue where the mitochondria reside. Any process
is also the intention of this chapter to eliminate the that inhibits the transport of oxygen from the atmos
anxiety experienced by professionals because of the phere to the cellular level can cause tissue hypoxia
plethora of attachments to the cardiopulmonary pa and ultimately death.
tient. Interaction with the various modalities and One of the most common drugs that a respiratory
pieces of equipment is also discussed. therapist uses is oxygen. Patients with cardiopul
749
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750 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
monary problems frequently need oxygen supple The nasal cannula, also called nasal hi-prongs, is
mentation. Respiratory therapists and the nursing one of the most common low now devices encoun
staff are generally responsible for administration of tered because of its low expense and high patient
this drug under a physician's order. There are several compliance (Figure 4 1-]). This device supplies be
different methods a therapist may choose to deliver tween 24% and 40% oxygen with flow rates from I
oxygen in the most effective way. Llmin to 6 Llmin. Flow rates above 6 Llmin can
The purpose of oxygen therapy is to treat and to cause nasal mucosa irritation and drying. The approx
prevent hypoxemia, excessive work of breathing, and imate liter flow and resultant Flo2 values are shown
excessive myocardial work (Kacmarek, Mack, and in Table 41-1.
Dimas, 1 990). Although individual oxygen appli Nasal canulas deliver 100% oxygen, however, this
ances offer suggested guidelines regarding oxygen percentage significantly lessens as the oxygen mixes
administration, the only way to ensure effective de with inspired air from the room. The amount of oxy
livery from a given device is blood gas monitoring of gen delivered depends on the now rate and the venti
Pao2, partial pressure of oxygen in the arterial blood latory pattern of the patient. A larger minute volume
or by monitoring hemoglobin saturation by oximetry. (TV x RR) would dilute the oxygen at any given flow
Oxygen therapy can be administered by one of two rate causing a greater decrease in the percentage de
methods-low-flow and high-flow systems. livered to the lungs. In other words, the faster and
deeper a patient breathes, the more diluted the oxy
gen will become. On the other hand, if a patient has a
Low-Flow Systems
low minute volume, the oxygen percentage delivered
A low-flow oxygen system is that which does not in will increase (Kacmarek et aI., 1990). If precise con
tend to meet the total inspiratory requirements of the trol of Flo2 is needed, the nasal cannula should not be
patient. This method of oxygen delivery is not used used (Bazuaye, Stone, Corris, and Gibson, 1992).
when a specific concentration of oxygen is needed Mouth breathing by patients on a nasal cannula
(Burton, Hodgkin, and Ward, 1991). typically causes the attending health-care provider to
switch the patient to a mask; however, this may be un
necessary. If the nasal passages are unobstructed, then
oxygen is able to collect in the oral and nasal cavity
(anatomical reservoir). On inspiration, the oxygen col
lected in this area is drawn into the airway system. If a
patient with a nasal cannula is mouth breathing, the
practitioner should ensure the nasal passages are un
obstructed. If there is concern that the patient is not
TABLE 41-1
I 24
2 28
3 32
4 36
5 40
FIGURE 41-1 6 44
Oxygen cannula.
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41 Respiratory Care Practice Review 751
receiving adequate oxygen, an oxygen saturation mea cheal oxygen catheters are more efficient than nasal
surement should be obtained. If this is not feasible, or cannulas, and they have a high patient acceptance
if the patient is unable to breathe through the nose, it rate with low complications (Kent, et a!., 1987). Be
would be appropriate to switch the patient to a mask. cause the oxygen is administered directly into the tra
Breathing through the nosc should be encouraged chea, 50% less oxygen is needed (Kacmarek et a!.,
to receive maximum benefil from the nasal cannula; (990). For people who use portable oxygen systems,
however, mouth breathing does not mean the patient and for those who require high oxygen flow rates,
is not receiving oxygen (Dunlevy & Tyl, 1992). tracheal oxygen catheters may be beneficial (Jackson,
The simple mask, or open-face mask, is another King, Wells, and Shneerson, 1992). The catheter can
low-flow oxygen delivery device commonly used. It be covered by the patient's clothing, therefore, it is
can deliver from 40% to 60('>(; oxygen, depending on cosmetically appealing.
the flow rate and the patient's ventilatory pattern.
This device requires a flow rate of 5 to 6 Llmin to
HIGH-FLOW SYSTEMS
prevent rebreathing and excessive respiratory work
(Jensen, Johnson, and Sandstedt, 1991). As with the A high-flow oxygen delivery system is that which de
nasal cannula, this type of oxygen delivery method livers a specific oxygen concentration despite the pa
should not be used if precise control of oxygen con tient's ventilatory pattern. If it is found that a patient
centration (FI02) is required. requires oxygen delivered at an FIo2 of 50% to keep
The partial rebreathing mask is basically a mask the oxygen saturation at a safe level, then a high-flow
with a reservoir bag attached. The oxygen source system would be the method of choice.
supplics the bag with 100% oxygen where it mixes This type of system is also used when there is fear
with exhaled anatomical dead-space-air that has not of administering too much oxygen to a hypercapneic
taken place in gas exchange. This exhaled air is rich patient. The respiratory drive to breath could be re
in oxygen. The exhaled air that has taken place in gas duced and possibly result in apnea. Precise control of
exchange and contains CO2 is vented through the low-concentration oxygen is warranted in such cases.
open ports on each side of the mask. This mask can
deliver oxygen concentrations from 70% to more
than 80%, and it requires flows between 7 and 10
Llmin to keep the bag from fully collapsing during
inspiration (Kacmarek et a!., (990).
The nonrebreathing mask is another low-flow de
livery device that also contains a bag reservoir, but it
can deliver up to 100% oxygen. This mask contains
valves at the reservoir bag and the side vents to pre
vent ambient air mixing on inspiration and exhaled air
mixing on expiration. In order for this mask to operate
effectively, a good seal between the patient's face and
the mask should be achieved. The bag should partially
deflate during inspiration (Figure 41-2).
Another interesting form of low-flow oxygen de
livery is the transtracheal oxygen calheter. This
method has gradually gained wider acceptance as a
long-term oxygen delivery device. It is surgically FIGURE 41-2
placed into the trachea via a small incision between Left to right, mask without bag, partial rebreathing bag,
the second and third tracheal rings. Generally, these nonbreathing bag. NOTE: the valves on the mask and at the
devices are seen in home-oxygen patients. Transtra junction between the mask and bag.
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752 PART VIH Related Aspects of Cardiopulmonary Physical Therapy
FIGURE 41-4
A, Heated aerosol. B, Nebulizers.
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41 Respiratory Care Practice Review 753
RESPIRATORY MODALITIES
Intermittent Positive Pressure Breathing
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754 PART VIII Related Aspects of Cal'diopulmonary Physical Therapy
FIGURE 41-6
FIGURE 41-7
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41 Respiratory Care Practice Review 755
The purpose of the IPPB machine is to increase rina. This humidification process is important to mu
alveolar ventilation, to improve the ventilation-pelfu COlIS production, ciliary activity, and a healthy respi
sion ratio, to mobilize and facilitate expectoration of ratory tract. When this normal humidification process
thick secretions, to decrease the work of breathing, is interferred with, other methods of adding moisture
and to deliver aerosolized medications. It is a pres to the respiratory system must be employed.
sure-cycled ventilator that, when triggered by a pa Humidification is the addition of water vapor in its
tient's inhalation, delivers ambient air or oxygen to molecular form to a gas. When a dry gas is being ad
the patient until a preset pressure is rcached. It is ba ministered to a patient (e.g., via a nasal cannula),
sically a lung expansion device that helps deliver an some type of humidification appliance would be used
increased tidal volume. IPPB is used for a variety of to prevent unneccssary complications. Flows of 2
pulmonary conditions, and treatment scssions usually Llmin or less may not require humidification when
last 10 to 15 minutes. using a nasal cannula. Humidification therapy is also
This modality comes into question in the clinical indicated in the presence of thick tenacious secretions
setting because it has not shown to provide benefits and when an artificial airway is in place. Artificial
over that of other simpler respiratory treatment meth airways, such as endotracheal and tracheostomy
ods. It also introduces potential complications and tubes, bypass the normal humidification system (the
hazards that the other treatments do not. Typically, upper airway); therefore, supplementation is essential
IPPB has been used to treat asthma, COPO, and post (Frownfelter, 1987).
operative atelectasis; however, other therapies, such There are basically two types of humidifiers. Bub
as incentive spirometry (IS), postural drainage, and ble-through humidifiers are those which are generally
aerosol therapy, tend to prevai I as the treatment of used with simple oxygen appliances. The pass-over
choice over IPPB. type of humidifier is usually found in conjuction with
Although IPPB is questionable regarding its clini a mechanical ventilator. Both bubble-through and
cal efficacy, it may be a beneficial form of treatment pass-over humidifiers are available for ventilators,
in acute asthma or COPO that is refractory to stan and they are usually heated to warm the humidified
dard therapy, atelectasis that has not responded to air to body temperature before entering the airway
simpler therapy, and the prevention of respiratory (Kacmarek et ai., 1991).
failure in patients with kyphoscoliosis and neuromus
cular disorders (Handelsman, 199 I).
Aerosol Therapy
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756 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
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41 Respiratory Care Practice Review 757
FIGURE 41-9
A, Puritan Bennett 7200a microprocessor driven ventilator. B, Bennett MA-I ventilator-bellows
system driven by an electric compressor.
tion and provide a foundation from which to make ap tive pressure breaths to a patient. Positive pressure
propriate decisions when working in this environment. ventilation is opposite of normal physiological venti
Many disease states that lead to cardiac and/or res lation in that normal ventilation occurs when negative
piratory failure will require mechanical ventilation to pressure, created by contraction of the diaphragm,
support the patient's effort to ventilate and oxygenate causes air to enter the lungs. Whereas normal inspira
(Figure 41-9). Today, patients receiving mechanical tion occurs by "pulling" air into the lungs, ventilators
ventilator support can be found in both the hospital "push" air into the lungs. This is important in that the
and the home. Acute exacerbations of disorders such thoracic cavity becomes an area of higher pressure,
as emphysema, COPD, and chronic hronchitis com which may create adverse cardiovascular and hemo
monly require mechanical ventilation and are gener dynamic events.
ally seen in hospital rcus. Disorders requiring long
term ventilation, such as spinal cord injury, brain
Modes of Mechanical Ventilation
injury, and certain neuromusculoskeletal diseases,
may be found receiving mechanical ventilation in the The physician and respiratory therapist have a nev
home or long-term care facility. erending sea of choices in which to choose the most
Today, mechanical ventilator assistance is pro appropriate method of ventilation. This area some
vided primarily by machines that deliver preset posi times presents confusing terminology and a lack of
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758 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
consistency. In fact, choosing the appropriate mode breaths with the patient's spontaneous breaths. In
of ventilation may be considered more of an art than IMV the machine may cycle a breath before the
a science. Before describing the modes of ventilation, patient can completely exhale a spontaneous
the following terms should be defined: breath. If no inspiratory effort is present, the ma
1. Trigger-Variable that causes a breath to be chine delivers the mandatory breaths.
delivered by the ventilator. A patient may inhale •
Continuous positive airway pressure (CPAP).
causing the ventilator circuit pressure to drop to The patient spontaneously breathes and a preset
a preset number (i.e., less than 1 or 2 em H20). level of pressure is constantly maintained. This
This is called a pressure trigger. Some ventila method of ventilation can also be achieved
tors are volume and flow triggered. through use of commercially available pneumati
2. Flowrate-The speed at which the ventilator cally powered units that hook directly into the
breath is deli vered. This parameter is usually oxygen wall outlet. A tight fitting mask is secured
measured in liters per minute. around the patient's mouth and nose, and a preset
3. Frequency-R e fers to the number of breaths pressure and oxygen percentage is delivered.
delivered over time (e.g., 10 breaths per minute). • Airway pressure release ventilation (APRV).
4. Spontaneous breath-Breathing through the The patient is allowed to spontaneously breathe
ventilator circuit without assistance. with a set amount of CP AP. If additional ventila
The following is a descri ption of common current tion is required, the CPAP will be dropped period
ventilator modes: ically, releasing the pressure, causing the patient
•
Controlled mechanical ventilation (CMV). The to exhale. When the exhalation is complete, CPAP
control mode is a lesser used method of ventilation is restored. Proponents of this mode claim that by
and generally requires the patient be sedated and allowing the patient control, patient comfort and
paralyzed. The ventilator delivers all breaths at a compliance are high.
p r e s e t f re q uency, volume or p r e s sure, a n d • Pressure support ventilation (PSV). In using
flowrate. T h e patient cannot take spontaneous pressure support the patient is allowed to breathe
breaths or trigger the machine. spontaneously and receives a preset amount of
•
Assist control (AC). The patient receives a preset inspiratory support until the fIowrate reaches a
pressure or volume, f requency or number of minimal level. The patient controls the fre
breaths, and fIowrate. In between machine-cycled quency, tidal volume, inspiratory time. This
breaths, the patient can trigger the machine to de mode is often used in conjuntion with SIMV.
li ver another breath at the preset parameters. All This mode is also popular due to high patient
breaths are machine delivered. No spontaneous compliance.
breathing can occur. •
Mandatory minute ventilation (MMV). The pa
•
Assisted mechanical ventilation. This mode is tient is allowed to breathe spontaneously; how
similar to AC, however, there is no set frequency. ever, a minimal level of minute ventilation will be
The patient triggers the machine at will to deli ver achieved through ventilator-assisted breaths. This
a set pressure or volume at a set fIowrate. is usually accomplished by using PSV.
•
Intermittent mandatory ventilation (lMV). As • Volume-assured pressure support (V APS).
the ventilator delivers a set mandatory frequency This is one of the newest modes of ventilation. It
and volume or pressure, the patient is allowed to allows the patient to breathe spontaneously in the
take spontaneous breaths between cycles. This is a PSV mode and monitors each breath's tidal vol
former popular mode. ume. If the breath is not going to reach the set
•
Synchronized intermittent mandatory ventila volume, the ventilator will hold the fIowrate con
tion (SIMV). This mode improves on that of IMV stant and increase the pressure until the desired
in that it synchronizes the machine delivered volume is reached (Branson and Chatburn, 1992).
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41 Respiratory Care Practice Review 759
SUMMARY
REVIEW QUESTIONS
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760 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
References
Fuller, H.D., Dolovich, M.B., Posmituck, G., Pack, W.W., & New
Ashworth, HL, Wilson, CG., Sims, E.E., Wotton, P.K., & Hlirdy, house, M.T. (1990). Pressuril.ed aerosol versus jet aerosol de
lG. (1991). Delivery of propellant soluble drug from a metered livery to mechanically ventilated patients. Comparison of dose
dose inhaler. Thorax, 46(4),245-247. to the lungs. American Rel'iew of Respiratory Disease. 141(2),
Barharash, R.A., Smith, L.A., GOdwin, J .E., & Sahn, SA (1990). 440-444.
Mechanical ventilation. DICP, The Annals of Pharmacother >f' Handelsman, H. (1991). Intermittent positive pressure breathing
apy. 24, 959-970. (IPPB) therapy. Health Technology Assessment Reports. 1. 1-9.
Bazuaye, E.A . , Stone, T.N , Corris, P.A., & Gibson, GJ. (1992) -J Hodgkin, J.E., Connors, G.L., & Bell, e.w. (1993). Pulmonary re
Variability of inspired oxygen concentration with nasal cannu habilitation guidlines to success (2nd ed.). Philadelphia: JB
las. Thorax,4 7(8 ) , 609-611. Lippincotl.
ranson, R.D., & Seger, S.M. (1988). Bronchial hygiene tech Jackson, M., King, M.A., Wells, F.e., & Shneerson, J.M. (1992).
niques. In R.M. Kacmarek, & 1.K. Stoller. C urren l respiralory Clnical experience and physiologic resulls with an implantable
care (pp. 24-28). Philadelphia: B.e. Decker. intratracheal oxygen catheter. Chest, 102(5), 1413-8.
Branson, R.D., & Chatburn, R.L. (1992). Technical description and Jensen, A.G., Johnson, A., & Sandstedt, S. (1991). Rebreathing
classification of modes of ventilator operation. Respiralory during oxygen treatment with face mask. The effect of oxygen
Care, 37(9),1026-1044. flow rates on ventilation. Acta Anaesthesiologica Scandinal'
-*' Burns, S.M. (1990). Advances in ventilatory therapy: high-fre ica, 35(4),289-292.
quency, pressure support, and nocturnal nasal positive pressure Kacmarek, R.M., Mack, e.W., & Dimas, S. (1990). The essentials
ventilation. Focus on Critical Care. 17(3),227-237. o{respiratory care (3rd ed.). SI. Louis: Mosby.
f Burton, G.G., Hodgkin, J . E., & Ward, J.J. (1991). Respiratory care Kent, e., et a!. (1987). A program for transtracheal oxygen deliv
a guide to clinical practice (3rd ed.) (pp. 524-525). Philadel ery: Assessment of safety and efficacy. Annals of Internal
phia: J.B. Lippincott. Medicine, 107,802-808.
Duffy S.Q., & Farley, D.E. (1992). The protracted demise of med Orens, K.D., Kester, L., Fergus L.e., & Stoller, J.K. (1991). Cost
ical technology: the case of intermittent positive pressure impact of metered dose inhalers vs small volume m:huli/.crs in
breathing. Medical Care, 30(8),718-734. hospitalized patients: the cleveland clinic experience. Resp ira
..( Dunlevy, e.L., & Tyl, S.E. (1992). The effect of oral versus nasal tory Care, 36( I 0), 1099-1104.
breathing on oxygen concentrations received from nasal cannu Pilbeam, S.P. (1992). Mechanical ventilatioll physiological alld
las. Respiratory Care, 37(4),357-60. clinical applirllliol1s. St. Louis: Mosby.
Frownfelter, D.L. (1987). Chest physical therapy and pulmanary ",*, .zadai, e.e. (1992). Pulmonary manogclllcnt in phvsical therapy.
rehabilitation an interdisciplinary approach (2nd ed.). St New York: Churchill Livingstone.
Louis: Mosby.
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Care of the Patient With
an Artificial Airway
HISTORICAL PERSPECTIVE
purposes: (I) to bypass upper airway obstruction,
An artificial airway is a tube inserted in the trachea (2) to assist or control respirations over prolonged pe
either through the mouth or nose or by a surgical in riods, (3) to facilitate the care of chronic respiratory
cision. Artificial airways have been known to med tract infections, and (4) to prevent aspiration of oral
ical science for 3000 years. George Washington ulti and gastric secretions. Multiple disease processes and
mately died of upper airway obstruction because his traumatic problems can require an artificial airway,
p h ysicians could not agree on t h e use of tra but each situation, simple or complex, can fit into one
cheostomy. It was not until 1909, when Chevalier or several of these categories (see box on p. 762).
Jackson published his classical paper on tracheotomy,
that this procedure gained some acceptance. The pro
INDICATIONS OF NEED-OBSERVATION
cedure did not become a highly specialized technique
in patient care until the invention of modern tra The respiratory care team can play a vital role in rec
cheostomy tubes and the development of intermittent ognizing patient need for a tracheostomy from physi
positive-pressure ventilators. In today's clinical prac ological changes that indicate respiratory distress.
tice, artificial airways have the following four basic Cardinal signs of dangerous airway obstruction are
761
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762 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
Disease Processes that CouLd Require all ArtificiaL Airway because of Respiratory Illsufficiency
I. Primary lung disease (e.g.. emphysema. chronic bronchitis, pulmonary fibrosis. cystic fibrosis, severe pneumonia,
burned lung, and toxic inhalation).
2. Systemic disease with secondary lung involvement (e.g.. cardiac failure, renal failure (fluid overload), and Illulti
organ system failure).
3. Neuromuscular disease (e.g., polio, Guillain-Barre syndrome, my asthenia gravis usc of muscle relaxants. and
,
tetanus).
4. Central nervous system depression (e.g.. drugs, postanesthesia, metabolical coma. cerebrovascular accident,
meningitis. and central nervous system tumors).
7. Mechanical obstmction (e.g., upper airway infection. laryngeal paralysis, tumor. edema. bleeding. foreign body,
and thyroid malignancy).
8. Recurrent aspiration (e.g .. glottic incompetence, occlusive diseases of the esophagus, and swallowing disorders of
various causes).
From Selecky PA: Tracheostomy-a review of present day i ndicat ions complications and
, care, !-Iellrt Lung 3: 272-283, 1974.
stridor and chest wall retractions. Early clinical signs long-term intubation. The nasal tube is more efficient
may include restlessness, agitation, tachycardia, con in that it is better secured, the patient may eat, it is
fusion, motor dysfunction, and decreased oxygen sat easier to suction, and it is generally more comfortable
uration on pulse oximetry. These signs may be ac for the patient.
c o m p a n i e d by h e a d a ch e , f l a p p i n g t r e m o r, a n d There are certain complications with nasotracheal
diaphoresis. Cyanosis from impaired oxygenation of tubes. Among these are sinus blockage and pain,
the blood is a late, ominous sign. vocal cord damage, or pressure necrosis to the carti
In children, restlessness must be due to lack of laginous structure of the nose. To reduce these com
oxygen unless another factor (e.g., thirst) is clearly plications, the airway should be evaluated daily. The
evident. Extreme fatigue and an inability to sleep in tube should be removed as quickly as possible when
dicate impending danger. Apprehension, restlessness, the indication for intubation is reversed. However, if
and mental confusion at any age may be taken as there appears to be a need for a more long-term air
early signs of hypoxia. way, a tracheostomy should be considered. The pro
cedure should not be taken lightly because many ad
ditional complications may occur.
Complications of Tracheostomy
Complications of tracheostomy can be surgical,
The selection of the appropriate airway is made by postoperative, or physiological. Complications that
the following factors:(I) What is the best means of occur at the time of the operation are more frequently
accomplishing the goal? (2) Is it an emergency or a direct results of the surgical procedure itself. Delayed
controlled, determined situation? (3) Will the airway complications may result directly or indirectly from
be needed for long-term care? In general, oral endo surgery, from postoperative care, or from the abrupt
tracheal tubes are inserted in emergencies. They are physiological changes resulting from tracheostomy.
the quickest and easiest tubes to insert even for rela Nursing objectives in caring for the patient after a tra
tively untrained personnel. A nasotracheal tube will cheostomy are to maintain patency of the tube, clean
generally replace the oral endotracheal tube for a liness of the wound site, and good aeration and to ob
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42 Care or the Patient With an Artificial Airway 763
serve any changes in the patient's vital signs and oxy A patient with an artificial airway is understand
genation by pulse oximetry. ably apprehensive and has special communication
In patients with artificial airways the normal phys needs. He or she should also be reminded that the in
iological mechanism for adding moisture to the air ability to phonate is only temporary. The patient must
via the nasal mucosa obviously is bypassed. There be reassured that he or she will be attended to con
fore supplemental humidification is extremely impor stantly and will be able to trust and depend fully on
tant to protect the mucosa from drying and crusting, the nursing staff to attend to his or her needs. If alert,
which results in obstruction. the patient must be equipped with a signal light or
The dressing under the tracheostomy tube and tra bell, paper and pencil, magic slate, or picture board
cheostomy ties should be changed when they become for communication.
soiled because dried blood and other secretions near Airway obstruction is the foremost complication that
the incision can encourage bacterial growth. The inci exists for the postoperative tracheostomy patient. Tra
sion should be checked frequently for bleeding. The cheal secretions are the major source of obstruction,
skin may be cleaned with half-strength hydrogen per particularly if they are excessive or viscous. When
oxide and sterile saline when a new dressing is ap using cuffed tube, acute obstruction might occur from
plied. The dressing should be folded into place overinflating the cuff, which would allow it to balloon
never cut. This eliminates the possibility of lint or over the end of the tube. Other causes of obstruction are
frayed threads being aspirated. Commercially pre dislodgement of the tube into a false tract anterior to the
pared dressings best meet these criteria. tube tracheal opening, occlusion by an overinflated
When changing the tapes that hold the tube in cuff, and kinking of softened plastic cannula.
place, it is best to have one nurse hold the tube in Tracheobronchitis, inflammation of the trachea and
place while another replaces the old tapes. An angle bronchus, is a complication resulting primarily from ir
is cut at the end of the tape to facilitate its placement ritation resulting from incorrect suctioning technique.
through the flange of one side of the tube. The tape is Crusting is a common and complex problem that
then threaded through the back of the tracheostomy may result from inadequate humidification of inspired
tube and through the other flanged opening and tied air or may result from dehydration. In many instances,
securely with a square knot placed on one side of the ulceration of the tracheal mucosa results from irrita
patient's neck. One finger should be placed under the tion by the airway or incorrect suctioning. This ulcer
twill tape while tying to prevent the tape from being ated area becomes infected with various organisms
tied too tight. and is virtually covered by crust. Further suctioning
Pneumothorax can occur immediately after tra removes the crust, causing discharge of serum and
cheostomy because of laceration of the mediastinal bleeding. The discharge produces a wet eschar that is
pleura at the time of surgery or within 24 hours (arises covered with mucus. Because of the drying effect of
often in children and patients with chronic obstructive air passing over this mass, a hard crust can form. This
lung disease). Other problems include air embolism, process can compound the difficulty because the de
aspiration, and subcutaneous and mediastinal emphy velopment of this crust in the trachea might eventually
sema. Recurrent laryngeal nerve damage or posterior produce a mass large enough to completely plug the
tracheal penetration may occur but is uncommon. tracheal cannula and almost completely obstruct the
trachea. Cases have been cited where an entire cast of
the tracheobronchial tree has been removed.
Postoperative Physiological Complications
Other physiological complications may be related
Attentive nursing care is the single most essential to the following: (1) hypoxia developing before or
factor in postoperative management. A ratio of one during the procedure and resulting in an uncontrol
nurse for each patient is the ideal; however, since this lable patient, cardiac arrest, and increased myocardial
is not often possible, increased vigilance by the entire sensitivity to adrenalin; (2) alkalosis developing from
respiratory care team is of vital importance. rapid carbon dioxide wash-out after establishment of
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764 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
the airway, resulting in myocardial fibrillation and tube can be replaced by the nurse on written order of
apnea; (3) cardiac fa i lure resulting in profuse bron
, the physician.
chorrhea caused by pulmonary edema and shock.
Other chronjc complications cited by Dailey, Simon,
TRACHEOSTOMY TUBES
Young, and Stewalt (1992) include the following: (1) in
fection at the surgical site, (2) aspiration, (3) aerophagia,
Metal Tubes
(4) persistent stoma, and (5) tracheal stenosis.
Tracheostomy tubes are of two basic types-metal
and polyvinyl chloride (hard and soft). Metal tubes
Postoperative Mechanical Complications
can be made of either stainless steel or sterling silver
Dislocation of the tube may result from unsatisfactory and composed of the following three parts: (I) an
nursing care, poor attention to the airway during posi outer cannula that fits into the tracheal incision,
tioning, or ventilator tubing pulling on the airway. If (2) an inner cannula that fits into the outer cannula,
the tracheostomy tube tapes are not kept tight and tied and (3) an obturator. Before the outer cannula is in
with a square knot or if they become loose as a result serted into the tracheal incision, the obturator is
of cervical emphysema or edema, the tube may be placed inside. The lower end of the obturator pro
coughed out of the trachea and become lodged in the trudes from the end of the outer cannula and facili
tissues of the neck and obstruct the airway. tates its insertion into the trachea. This is the only
Stay sutures are useful in tracheostomy patients purpose of the obturator. The protruding end of the
when there is the possibility of tube displacement. obturator obstructs the lumen of the outer cannula.
These sutures are valuable during recannulization of When the obturator is removed, immediately replace
the tube if it comes dislodged before a tract has been it with the inner cannula. When dealing with metal
well established. Stay sutures will prevent entry into tubes, the parts of each set are not interchangeable
a false tract. Advantages of this technique include the and fit only one particular set. If one part is lost or
following: (I) blockage or displaced tubes can be damaged, the entire set is useless. Therefore each
rapidly replaced, (2) exposure of the trachea at surgi part, including obturator, is accounted for carefully.
cal intervention is improved, (3) firm anchoring of Plastic tubes generally have interchangeable parts.
the trachea at the moment of incision, (4) decreased Care should be exercised in handling sterling silver
trauma associated with extubation, and (5) uniform tubes, since silver is easily dented.
tracheostomy technique for aJJ ages. Mucus that has dried inside the inner cannula can
Dislodgement of the outer cannula or required re not be cleaned by merely rinsing in water. The can
moval before a tract has been well established (usu nula should be soaked in hydrogen peroxide and
ally 5 to 10 days) again requires diligence and quick scrubbed with a tracheostomy brush and rinsed with
action by the nurse. No attempt at reinsertion should saline to be sure aJJ secretions have been removed. If
be made without adequate light, satisfactory tissue re a silver inner cannula becomes discolored, it may be
traction, tracheal hook, and a Trousseau's dilator. A cleaned with silver polish.
Trousseau's dilator and tracheal hook should be read The inner cannula should always be inspected to
ily available. A spare tracheostomy tube of the cor be sure it is clean and clear of secretions before it is
rect size should be kept at the patient's bedside at all reinserted. Be sure to lock the inner cannula in posi
.
times. Then, should the tube be coughed out, the tion after reinsertion.
nurse uses the Trousseau's dilator to hold the wound
apart while summoning the physician. Tragedies have
Polyvinyl Chloride (Plastic) Disposable
occurred from inserting the tube into the soft tissues
Tubes and Cuff Inflation
of the neck or mediastinum because of a dislodged
cannula and the frantic efforts to replace it. Once the The development of plastic tracheostomy tubes came
tracheostomy tract has been firmly established, the about for the following three important reasons:
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42 Care or the Patient With an Artificial Airway 765
(1) application of silicone to the inner sUliace of the fore insertion of the tube into the trachea to be certain
plastic tube minimizes crusting and adherence of se that there are no leaks. The Luer valve inflation port
cretions; (2) there is greater ease in attaching a safe, to the pilot balloon is self-sealing. Some Luer valves
dependable, permanent inflatable cuff to the plastic have a relief valve when pressure exceeds 25 mm Hg.
tube that cannot slip off and occlude the tracheal
opening; and (3) lower costs allow the tube to be dis
Cuff Inflation
posable. Plastic tubes come with and without cuffs.
The cuffed tracheostomy tube is primarily used in There are two commonly used methods of cuff infla
conjunction with a positive-pressure ventilator to tion. These are the minimal air leak, in which a small
form a closed system (Figure 42-1). It is also used to amount of air escapes on inspiration, and minimal oc
reduce the possibility of aspiration because of absent, clusive volume, in which just enough air is placed in
protective laryngeal, and pharyngeal reflexes. The in the cuff to stop air from escaping on inspiration. Ac
flatable cuff is located around the lower portion of cording to Crabtree Goodnough (1988), the minimal
the tube and, when inflated, seals the trachea from leak cuff technique may produce less injury than the
most airtlow except through the tube itself (see Fig minimal occlusive volume inflation technique. Re
ure 42-1). The cuff, usually made of pliable plastic, is gardless of which technique is used, the pressure of
inflated by injecting air into the fine-bore tubing. A the cuff should be checked every 4 to 8 hours and the
small pilot balloon is located proximally in the tubing pressures documented. With continued research and
and indicates that the cuff is inflated. The nurse must monitoring of tracheal cuff pressures, potential tra
check the inflation end of the cuff and the balloon be cheal injury can be prevented.
FIGURE 42-1
A, Cuffed adult tracheostomy tubes, uncuffed pediatric tracheostomy tube (far left). B, Cuffed adult
endotracheal tubes, uncuffed pediatric endotracheal tube (far left).
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766 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
Once the cuff is inflated, the only route for air ex ideall y every 8 hours but at least once every 24 hours.
change is through the patient's tracheostomy tube; The Communitrache I is a tracheostomy tube that
therefore careful observation of the patient by the permits the removal of secretions above the inflation
nurse is essential. If the patient is on mechanical ven cuff without nasotracheal suctioning. The other plus
tilation, observation is essential if there is ventilator factor to this tracheostomy tube is the patient's ability
failure because asphyxiation may occur. Alarms are to communicate, especially while on a ventilator.
always in the "on" position when a patient is being When the patient is weaned from the ventilator, a
mechanically ventilated. Some means of resuscita fenestrated tube may be used. Fenestrated comes
tion, such as a manual resuscitating bag with mask, from the French word jenesfre, meaning window.
must be available at the bedside to ventilate the pa There is a window (fenestration) in the outer cannula.
tient in case the tracheostomy tube comes out or is When the tube is used for speaking the cuff is down,
dislodged. the inner cannula removed, and an external plug is in
Considerable emphasis has been given to the inci serted to cap the tracheostomy tube to allow the pa
dence of tracheal ischemia and resulting stenosis tient to speak. The cuff must be deflated when the
from the use of a cuffed tube. This ischemia results cap is in place. If the cuff was inflated, the patient
from the pressure of the cuffed tube against the tra would be unable to breathe air into the lungs. The pa
cheal wall, which heals with scar formation, resulting tient exhibits immediate distress if this mistake is
in subsequent stenosis. This complication can be re made. If a patient with fenestrated tube needs to be
duced or eliminated by minimal air leak or minimal suctioned, the inner cannula must be placed so that
occlusive volume. For the minimal occlusive volume, the suction catheter does not enter the fenestration
the cuff must be inflated to eliminate any air leak on and cause injury to the tracheal wal.l mucosa.
inspiration. Cuff pressures should be monitored and
documented every 4 to 8 hours to prevent tracheal in
Other Airway Devices
jury. The recommended cuff pressure is I S to 2S mm
Hg. Inflate the cuff until there is no air leak between The Olympic tracheostomy button is used as an in
the wall of the trachea and the cuff, and then release a terim airway after tracheostomy tube removal (Figure
small amount of air to allow only a slight air leak be 42-2). This method is another example of weaning a
tween the walls of the trachea and the cuff. This re patient from tracheostomy tube but still maintaining
duces the pressure of the cuff, still allows the ventila the stoma should a tracheostomy be again needed.
tor to function properly, and reduces the likelihood of The patient that benefited most from the procedure
tracheal ischemia. Any difficullY in properly inflating was the COPD patient. This was one method used to
the cuffed tracheostomy tube should be immediately facilitate secretion removal after hospitalization when
reported to the physician. it became necessary because of the disease proces?
If the tracheotomized patient is conscious, he or The Olympic tracheostomy button allowed the tra
she may attempt to speak. If the cuff is properly in cheostomy patient the opportunity to reestablish an
flated, he or she will be aphonic, since no air can pass unobstructed airway and at the same time allowed the
over the vocal cords. If he or she needs to speak, the patient to speak.
cuff can be deflated, and the patient may be given a The Passy-Muir valve is used for patients with
sterile dressing to hold over the tube. This will allow upper airway obstruclion, and with difficult decannu
him or her to speak and also simulate a cough by lation (Figure 42-3). The Passy-Muir is a one-way
rapid exhalation to clear secretions. valve, allowing inspiration only and forcing exhala
Inspired air must be continuously and adequately tion through the upper airway. By using the valve the
humidified by means of nebulizing equipment to pre upper airway muscles gradually recover, allowing for
vent the formation of crusts. The equipment used for transition to a fenestrated tube or a smaller size tra
this purpose can be a possible source of infection. cheostomy tube and preparing the patient for eventual
Therefore the nebulizer and tubing should be changed decannulation (Pierson and Kacmarek, 1992).
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42 Care of the Patient With an Artificial Airway 767
-I
FIGURE 42-2
Dimensions and actual positiorung of an Olympic tracheostomy button. (From Pierson OJ and Kacmarek
RM: Foundations of respiratory care, Churchill Livingstone, 1992, Edinburgh © David 1. Pierson.)
FIGURE 42-3
The Passy Muir Valve. This valve attaches to a standard lS-mm tracheostomy adapter. It allows
inspriation A, via the valve, but exhilation 8, must occur via the upper airway. (From Pierson OJ
and Kacmarek RM: Foundations of respiratory care, Churchill Livingstone, 1992, Edinburgh
© David J. Pierson.)
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768 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
Airway Care
\ Suclioning
I Proper explanation of the suctioning technique to the
patient helps allay apprehension and enhance cooper
ation. Medicate your postoperative patient before
suctioning to decrease the pain of coughing. Always
maintain a calm and reassuring manner.
Maintain aseptic technique throughout the entire
procedure. Use sterile gloves and a sterile disposable
catheter for each suctioning.
Position the patient properly unless contraindi
cated. Nasotracheal and/or pharyngeal suctioning
should be done with the patient in Fowler, 60 to 70
degrees, or semi-Fowler position, approximately 45
degrees, with the neck hyperextended (Figure 42-5).
FIGURE 42-4 The supine position is best for the patient with tra
The Montgomery T-tube. (Reprinted with permission from
cheostomy or endotracheal tubes (Figure 42-6).
Montgomery WW: Manual care of the Montgovery silicone
Pharyngeal suctioning may be necessary before de
tracheal T-tube. The annals of olOlogy rhinology &
flating the cuffed tracheostomy tube. The nurse should
lQ/yngology (supplement 73) 89(4): 3,1980.)
not suction the pharynx and then the trachea with the
same catheter, but the trachea may be suctioned first
and then the pharynx with the same catheter.
Duration of suctioning is of extreme importance.
Each suctioning procedure should last no longer than
The management of major airway obstruction 5 to 10 seconds to avoid hypoxia.
by tracheal tumor, external compression, or tra Prolonged suctioning may result in precipitating a
cheal disease below the thoracic inlet still present dysrhythmia or cardiac arrest. A good way to judge
difficult problems. The Montgomery T tube is a bi the elapsed time is to hold one's OWIl breath and be
furcated silicone rubber stent designed to preserve guided by the development of discomfort. This is
patency of the airways in a patient with injury to most important for the patient who depends on venti
the trachea or main bronchi (Figure 42-4). When latory assistance.
the T tube is in place, the patient breathes normally The lowest possible vacuum settings are to be llsed
through nose and mouth and can speak. The T tube (below 120 mm Hg) that will still support suctioning
is a method in which secretions can be removed if the tracheostomy tube. The higher the setting is
necessary and is helpful in long-term therapy to al raised, the greater the risk of trauma to the tracheal
l e v i a t e o b s t r u c t i o n or d u r i n g r e c o n s t r uctive mucosa. Caution should be exercised to avoid kinking
surgery. This device does not cause any adverse the suction tubing or catheter. When negative pressure
tissue reaction on a long-term basis, according to is excessive and released suddenly, inadvertent re
Montgomery. moval of portions of tracheal mucosa may occur.
Copyrighted Material
42 . t With
Care 0 f the Pahen . an Artificial Airway 769
FIGURE 42-5
A, Fowler ' s an
, dB, Semi-Fowler's positions.
FIGURE 42 6
Supine posillon,
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770 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
)(
FIGURE 42-7
The catheter will simulate coughing when it contacts the carina (in a patient with cough reflex).
FIGURE 42-8
The catheter is withdrawn I cm after it reaches the carina, before applying suction.
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42 Care of the Patient With an Artificial Airway 771
Insertion of the suction catheter should be done Right main-stem bronchus aspiration is the usual
gently, using aseptic technique and sterile gloves. case because of the more direct alignment of this
Goggles are used as part of universal precautions if bronchus with the trachea. This can be carried out al
there is any danger of coughed-ollt secretions. The most always with a straight tracheal catheter.
catheter should first be moistened in sterile saline or Excessive suctioning can be harmful. Use judg
with a water-soluble gel. Suction is not applied while ment to determine just how often a patient requires
the catheter is passed down into the trachea. Proper suctioning. Auscultation by stethoscope should be
insertion of the catheter will stimulate coughing when used to determine the thoroughness of suctioning.
it contacts the carina (Figure 42-7). It is then immedi Suction only when it is needed (Carroll, 1994). Allow
ately withdrawn I cm before suction is applied (Fig the patient to rest and breathe between each insertion
lire 42-8). Do not force the catheter lip and down of the suction catheter and, if necessary, ventilate him
while suctioning. Suction is applied only while the or her for few minutes before further suctioning. Re
catheter is being wi thdrawn. Rotating the catheter member each suctioning attempt removes air as well
during withdrawal results in suctioning a larger area as secretions. Hyperoxygenation and hyperinflation
and increases the surface contact of the trachea and with 100% oxygen has been suggested with better re
tracheostomy tube (Figure 42-9). sults and fewer complications. Complications from
Left main-stem bronchus aspiration is more diffi tracheal suctioning include the following: (l) hypox
cult because of the anatomical arrangement of the emia, (2) cardiac dysrhythmia, (3) bronchospasm,
bronchus. It was formerly thought that left bronchial and (4) infection. Suctioning can lead to hypoxemia
aspiration was facilitated by turning the patient's because oxygen is removed from the airways, and
head to the right. Studies by Kirimli et al. (1970) and this could lead to tissue hypoxia. To minimize this
Panacek et £II. (1989) indicate that left bronchial aspi problem, preoxygenation is recommended. This can
ration is best accomplished by using a Coude tip be done by hyperinflating the patient with Ilf2 times
catheter. After its insertion into the trachea. the their normal tidal volume on a ventilator and hy
curved tip should be positioned to point toward the perox-genating with 100% oxygen for 3 to 5 breaths.
left main-stem bronchus. Even so, insertion is diffi Cardiac dysrhythmias, such as premature ventricular
cult, and auscultation by stethoscope is necessary to contractures, bradycardia, and tachycardia, can be di
thoroughly access the suctioning. minished by hyperinflating and hyperoxygenating the
To suction unit
Connection
(
Detall
Air vent I
Catheter
FIGURE 42-9
The catheter is rotated during withdrawal in order to suction a larger surface area.
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772 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
patient with 100% oxygen. If any dysrhythmias occur 18. Discard used equipment and remove gloves.
on the monitor, the suctioning procedure should be 19. Wash your hands.
discontinued. Bronchospasm may be effectively pre
vented by a few puffs of a bronchodilator, such as al
Nasopharyngeal Airways
buterol, to the tracheostomy tube before suctioning.
Infection can be decreased by maintaining sterile When frequent, aggressive nasopharyngeal suction
technique with sterile gloves and sterile catheters ing is indicated in a semicomatose patient, a nasopha
when suctioning. ryngeal airway (NPA) will lessen the trauma of fre
quent passage of the catheter. The NPA is a soft latex
Suctioning Artificial Airway material that provides easy access to the trachea for
nasopharyngeal suctioning. The nasal and pharyngeal
Nasotracheal, Endotracheal, and Tracheostomy mucosa are protected and the procedure thus becomes
I. Check equipment, be sure you have all necessary more co mfortable to the patient. In addition, a
equipment and maintain sterile field. fiberoptic bronchoscope may be passed through the
2. Check monitors. airway if the procedure is indicated.
3. Wash your hands.
4. Inform patient of the procedure.
Endotracheal or Tracheostomy Suctioning
5. Hyperoxygenate with 100% oxygen for three to
five breaths with manual resuscitation bag. The procedures are the same except sterile technique
6. Place patient's neck in extension. is followed and no lubrication is usually necessary,
7. Put on sterile gloves. although it may be used if there is difficulty passing
8. Lubricate catheter with sterile saline or water the catheter.
soluble gel.
9. Place catheter (without suction) upward and
Sterile Suctioning
backward in short increments. Continue until an
obstruction (the carina) is reached. The technique for correct sterile suctioning of artifi
10. When the carina is stimulated, the patient will cial airways is perhaps the most important and vital
generally cough un less his or her reflexes are segment of care for the patient because it removes se
obtunded. cretions that would otherwise obstruct the airway. If
11. The catheter should be pulled back slightly, from suctioning is not performed properly, it can cause
the carina, then suction applied with no more physiological or psychological trauma to the patient.
than 120 mm Hg pressure as catheter is with The equipment necessary for proper sterile suc
drawn in a rotating motion. tioning includes proper mechanical apparatus, con
12. The aspiration time should be within 10 to 15 sec necting tubing, sterile gloves, sterile saline, suction
onds total. (A good guideline is for the therapist to catheters, dressings, and goggles as indicated with
hold his or her breath during suctioning as the pa universal precautions. While suctioning the patient, it
tient is also not breathing. This gives the therapist a should be remembered that the patient's only air pas
better sensitivity for what the patient experiences.) sage is being partially occluded. Thus the suction
13. The patient should be allowed to rest for several catheter should never be larger than one half the di
seconds and again be preoxygenated. ameter of the tube opening; if it is larger, it may com
14. Check the patient's breath sounds and repeat the pletely occlude the patient's air passage.
procedure if necessary to remove more secretions. One method of determining the size of the catheter
15. Suction pharynx. used for suctioning is to double the size of the tra
16. The monitor is to be watched for any dysrhytlunias. cheostomy tube in place and add two. For example, if
17. Pulse oximetry is to be used for indications of the patient has a #6 tube, the calculation would be as
desaturation. follows: 6 + 6 = 12 + 2 = 14. Therefore a 14-fr catheter
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42 Care of the Patient With an Artificial Airway 773
2 PT 8FR
3 PT 10 FR
Extubalion/Decannulalion
4 PT IOFR
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774 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
tion of the patient's ability to ventilate must be done Goodwell, EW. (1':)34). The story of trach"ostolll)'. Srilish .Iour
l1al of ('hildren '.\' iJi.l'l'{/se.l', 31(367-36')),167-176.
when either of these devices are used in the decannu
Goodwell, E.W. (1934). The story of tracheostomy. Srilish Jour
lating process.
nal of Children's Diseases, 31(370-372),253-27 I.
Close supervision should continue after extuba Jackson, C (1909). Tracheostomy. Laryngoscope, 18,285-290.
tion. After a tracheostomy tube is removed, the skin Jackson, C (1921). High tracheostomy and other errors. The chief
edges are usually taped together with butterfly strips causes of chronic laryngeal atenosis. Surgery, CynecoIOfi.Y, Ob
slelrics, 32, 392-395
for a few days until the wound heals. While healing,
Jackson, D., & Albamonte, S. (1994). Enhancing communication
air will escape through the wound and reduce the ef
with the Passy-Muir valve. Pedialric Nursing, 20,(2),149-153.
fectiveness of the patient's cough. The patient should Kirchner, J .A. (1980). Tracheostomy and its problems. Surgical
be instructed that the noise from the partially closed Clinics ofNorih America, 60,(5), 1093-1104.
trachea is normal and small secretions should be re Kirimli, B., King, lE., & Pfaeffle, H.H. (1970). Evaluation of tra
cheobronchial suction technique. Journal of Thoracic and Car
moved from this area. The patient should be taught to
diovascular Surge!)" 59, 340-344.
hold a sterile dressing firmly over the incision when
Lull, J.M, Pierson, OJ., & Tyler, ML (1993). Methods of Air
coughing until the opening healed. way Maintenance. In Inlellsive respiralOry care. Philadelphia:
WB Saunders.
Mocaluso, S., & Roman, M. (1994). Managing post-intubation in
REVIEW QUESTIONS juries. Medsurg Nursing, 3(3),192-202.
Montgomery, W.W. (1989). Manual of care or the Montgomery
I. What physiological changes occur with surgical silicone tracheal T-tube. Annals of OlOlof!)" Rhinology and
placement of tracheostomy tube? La!)'ngology (Supp. 73),89(4),3.
2. Discuss possible psycosocial concerns of patients Montanari, 1., & Spearing, C (1986). Of measuring tracheal curf
pressure. Nursing, 86(7),46-49.
with a tracheostomy.
Noll, M.L., Hix, CD" & Scott, G. (1990). Closed tracheal suction
3. List information that you would include in a systems: effectiveness and nursing implications. In ArlCN clin
teaching plan for the tracheostomized patient. ical issues in crilical care nursing. Philadelphia: JB Lippincott.
4. How does the patient care team prepare the tra Panacek, E.A., Albertson, T.E., Rutherford, W.F., Fisher, C.J., &
Foulke, G.E. (1989). Selections left endobronchial suctioning
cheostomized patient for self care?
of the intubated patient. Chesl, 95,885-87.
5. Compare emergency care, acute care, and long
Patton, C (1991). The critical airway classic problems. CurrenI
term care for a patient with upper airway ob Reviews for Ihe p(1S! Aneslhesia Care NI/rses, 13(5),33-40.
struction and tracheostomy placement. Pierson, OJ., & Kacmarek, R.M. (1992). In Foundalions of respi
ralory care. New York: Churchill Livingstone.
Roberts, J.T. (1994). In Clinical Management of the Airway,
Copyrighted Material
Respiratory and Cardiovascular
Drug Actions
Arthur V. Prancan
INTRODUCTION
Before a drug can be used effectively, the system
The respiratory and cardiovascular systems have it is to modify must be understood. How the mecha
many built-in mechanisms for controlling their func nism of the drug action relates to the biological sys
tions during health and disease. In healthy individu tem must be clear before an effect can be predicted.
als, both systems act quickly and positively to main This chapter describes much of the basic respira
tain proper functioning under the most complicated tory and cardiovascular physiology that underlies the
conditions. Even during trauma or disease, these sys action of the drugs presented. Hopefully, the relation
tems often overcome distress and regain normal func ship between basic physiology and the drug mecha
tion. The physiology of respiration or circulation is nism of action is also evident.
sometimes altered by a disease so that the homeosta All pharmacological interventions for the respi
tic mechanisms are no longer effective. In such a ratory and cardiovascular systems are not covered.
case, a drug with the appropriate action becomes nec Certainly no attempt has been made to describe the
essary to restore normal physiological function. pharmacology of other systems or disease states.
775
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776 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
For further study, one of the books listed in the ref tagonistic action of the two components of the auto
erence section at the end of the chapter is highly nomic nervous systcm.
recommended. Some organs, however, have only one innervation.
Much of the arterial blood vessel network is con
trolled only by sympathetic nerves. Also, gastric se
AUTONOMIC PHARMACOLOGY
cretion and gastric motility are primarily regulated by
This section introduces the basic aspects of drug action one system-the parasympathetic.
related to both components of the autonomic nervous
system-the sympathetic and parasympathetic nervous
SYMPATHETIC NEUROTRANSMISSION
systems. For both systems, synthesis, storage, and re
lease of the chemical neurotransmitter are described to Sympathetic nerves transport impulses from the vaso
emphasize the places in the metabolical scheme where motor center in the medulla of the brain through the
drugs can intervene. The sites of action for the adrener spinal cord and out to the smooth muscle, heart mus
gic (sympathetic) and cholinergic (parasympathetic) cle, and secretory cells. These tissues have receptor
transmitters and blockers is also described. sites that will accept the norepinephrine released
The autonomic nervous system controls all of the from the nerve ending. Norepinephrine, also called
bodily functions over which you have no voluntary noradrenalin. is synthesized in the nerve ending only
control, and perhaps which you might not control as in the sympathetic neurons. It is stored in the terminal
well if you had the opportunity. The functions in until an electric impulse reaches the terminal, then it
clude regulation of respiratory airway diameter, res is released into the synapse.
piratory secretions, blood vessel diameter, heart rate, The norepinephrine molecule attaches to a recep
intestinal motility, pupil size, and many others. It is tor molecule on a cell sUlface in the immediate vicin
easy to see that it might take more than the talents of ity of its release. This drug-receptor combination
a well-trained expert to keep an active person func causes a biological change, such as stimulation of the
tioning day and night. pacemaker cells in the heart to fire more frequently
The sympathetic nervous system is the half of the (increased heart rate). The effect is terminated when
autonomic system that takes a dominant role in the the norepinephrine is reabsorbed into the nerve termi
cardiovascular and respiratory systems when some nal. About 90% of the released norepinephrine is
sort of bodily activity is necessary. This includes ac taken back into the neuron. There, it is either restored
tions such as increasing ventilation capacity, elevat into granules for future release or it is destroyed by
ing blood pressure, and shunting blood flow to the the enzyme monoamine oxidase (MAO).
skeletal muscles. Classically, the sympathetic compo There are two types of sympathetic receptors
nent of the autonomic nervous system has been called alpha and beta. The alpha-receptor is found in the
the fight-or-t1ight system. The other half of the auto arterioles, and the beta-receptor is found in the arte
nomic system is called the parasympathetic nervous rioles, heart, and bronchioles. Stimulation of the
system. It is most important in maintaining the less alpha-receptor in the arteriole causes vasoconstric
exciting functions of the body like digestion, saliva tion that results in increased blood pressure. The
tion, and urination. In some organs the two systems beta-receptor in the arterioles causes vasodilation
work against each other to provide very fast and very and a lowered blood pressure. Some drugs stimu
fine control. For example, the size of the pupil re late both receptors, and in those cases the effect
sponds quickly to a change in light intensity. The will be determined by the degree of alpha or beta
parasympathetic system actively functions to de activity of the drug. An example is norepinephrine.
crease the size of the opening while the sympathetic It has 90% alpha activity and 10% beta activity, and
system relaxes, thereby causing a quick decrease in it always causes vasoconstriction. Epinephrine is
pupil size. If the light is turned down, the opposite 50% alpha and 50% beta and may cause a rise or
occurs just as fast. This is a good example of the an drop in blood pressure.
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43 Respiratory and Cardiovascular Drug Actions 777
Epinephrine (Adrenalin)
Stimulation of the beta-receptor in the heart results
in increased heart rate (beats per minute) and in Epinephrine (Adrenalin) is also a mixed activity drug
creascd stroke volume (number of milliliters of blood (50% alpha, 50% beta). It is naturally produced in the
the left ventricle pumps out into the aorta every time adrenal medulla and can be released during sympa
it contracts). Incidentally, the combination of these thetic nervous system activation. When this occurs, it
two changes (heart rate [HR] x stroke volume [SV]) acts as a circulating hormone, stimulating both alpha
is another way of saying cardiac output (CO) (milli and beta-receptors. This drug wi II increase heart rate
liter of blood pumped per minute): and stroke volume and may slightly increase or de
crease total peripheral resistance at the arterioles. In
beats/min(HR) x mllbeat(SV) = mllmin(CO)
any case, cardiac output always goes up; blood pres
This expression, cardiac output, is a common one sure may go up or down slightly.
and it constitutes half of the blood pressure regulation In the bronchioles, epinephrine exerts a dramatic
equation: CO x TPR = BP, where CO is cardiac out dilating effect that is mediated by the beta-receptor.
put, TPR is total peripheral resistance, and BP is Epinephrine can be administered by inhalant aerosol
blood pressure. Total peripheral resistance is deter to reverse a bronchoconstrictive episode. It is also
mined by vasoconstriction or vasodilation in the arte administered intramuscularly and subcutaneously to
rioles. Vasoconstriction increases resistance so TPR treat asthma, anaphylactic reactions to an allcrgic re
and BP goes up. sponse, cardiac arrest, heart block, and as a mild
Stimulation of smooth muscle beta-receptors will vasoconstriction to keep local anesthetics at the in
relax these tissues wherever they are found. Respiratory jection siteo
airway smooth muscle will decrease tension when the
Isoproterenol (Isuprel)
beta-receptor is activated by beta-acting drugs like epi
nephrine or isoproterenol. The functional result will be Isoproterenol (lsuprel) is a synthetic compound that
an increase in air flow because of a larger airway diam has 100% beta activity. This means that it can in
eter. Likewisc, blood vessels respond to beta-acting crease heart rate and stroke volume to produce a great
drugs by increasing in diameter, allowing a greater rate rise in cardiac output, and it stimulates the beta-recep
of flow. In this case, TPR has decreased and blood tor on the arterioles to effect a profound vasodilation.
pressure will drop. The final result can be a high cardiac output with low
blood pressure. This drug improves blood circulation
in shock patients by increasing local blood flow (va
Adrenergic Drugs sodilation) and elevating cardiac output. Isoproterenol
is considered very useful for treating acute asthmatic
Norepinephrine (Levarterenol, Levophed) conditions because of its bronchodilating action.
As mentioned previously, n o repinephrine
Phenylephrine (Isophrin, Neo-Synephrine)
(Levarterenol, Levophed) is a mixed-activity drug
and Metaraminol
(90% alpha, 10% beta). It stimulates beta-receptors in
the heart, which results in an increase of heart rate Both phenylephrine (lsophrin, Neo-Synephrine) and
and stroke volume (increased cardiac output). In the metaraminol are powerful and prolonged stimulators
arterioles, norepinephrine causes vasoconstriction via of alpha-receptors. The action is directly on the re
the alpha-receptor, resulting in increased total periph ceptor site itself. The response to the administration
eral resistance. The total effect, of course, is an in of either of these drugs is a rise in blood pressure be
crease in blood pressure. Norepinephrine has little ef cause of vasoconstriction accompanied by a reflex
fect on the bronchioles. This drug is given only bradycardia, which causes a decrease in cardiac out
intravenously, and it can be used clinically to raise put. Reflex alterations of cardiovascular function are
blood pressure. The natural sympathetic compounds explained later in this chapter. The primary useful
are known as catecholamines. ness of these drugs is in various hypotensive states.
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778 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
Phenyle phrine is used as a nasal decongestant and asthma. The drugs are metaproterenol (Alupent,
mydriatic and for the relief of paroxysmal atrial Metaprel), terbutaline (Brethine, Bricanyl), albuterol
tachycardia. Phenylephrine affords relief from the (P r o v e n t il, Ven t o l i n ), i s o e t h ar ine ( B r on kosol,
tachycardia because it increases blood pressure and Bronkometer), and salmeterol (Servant).
evokes the cardiovascular reflex that is marked by
high vagal tone and bradycardia. Alpha-Adrenergic Blocking Drugs
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43 Respiratory and Cardiovascular Drug Actions 779
blood vessels, and the bronchioles. It prevents the beta crease in catecholamine response to sympathetic stim
adrenergic effect usually seen with drugs like epineph ulation. Blood pressure in humans does not drop dra
rine, norepinephrine, and isoproterenol. In the arteri matically with therapeutic doses of reserpine, but when
oles, when epinephrine is given after propranolol, the reserpine is used in combination with diuretics or other
usual mixed alpha and beta effect is eliminated, leav antihypertensive agents, a significant antihypertensive
ing only an alpha-adrenergic action. This causes pro effect is obtained. Reserpine is used in this way to treat
found vasoconstriction, allowing greater increase in essential hypertension. One serious side effect related
blood pressure than is normally seen with epinephrine to reserpine use is the behavioral modification that can
alone. In the heart the beta-receptors are blocked and, result in severe depression and suicide.
since there are no alpha-adrenergic receptors in this
organ, all effects of catecholamine drugs on the heart
Guanethidine (Ismelin)
are effectively eliminated, allowing the vagal influence Guanethidine (Ismelin) is an adrenergic neuron
on the heaJ1 to predominate. Propranolol decreases the blocking agent that works by replacing norepineph
heart's requirement for oxygen because it blocks the rine in the nerve terminal. Norepinephrine is usually
cardiac stimulant action of norepinephrine. In the res taken up by the nerve terminal after its discharge and
piratory system the administration of propranolol re i s r e u s e d to m a i n t ain g r a n u l e c o n c e n t r a t i o n s .
sults in bronchoconstriction. This effect is increased Guanethidine takes the place o f norepinephrine i n the
dramatically in patients who are susceptible to asthma. granules and prevents the reuptake of norepinephrine,
The main use for propranolol is in conditions related to thereby causing its metabolism outside of the neuron
hypertension and tachycardia, where a decrease in car and its eventual depletion. The result on the cardio
diac output is beneficial. vascular system of this action is postural hypoten
sion. The patient is unable to control blood pressure
Metoprolol (Lopressor) and Atenolol (Tenormin)
by sympathetic activity. This drug is used in treat
Metopolol (Lopressor) and atenolol (Tenormin) are ment of severe hypertension, usually after diuretics
beta-adrenergic antagonists that have been designed and reserpine are shown to be ineffective.
to be cardioselcctive. This offers an advantage in
Methyldopa (Aldomet) and Clonidine (Catapress)
safety when a beta-blocker must be used in asthmatic
patients, in whom this disease would be aggravated if Methyldopa (Aldomet) and c10nidine (Catapress) de
respiratory beta-receptors were blocked. The natural crease the activity of the sympathetic nervous system
beta-adrenergic agonist, epinephrine, is bronchodilat at its control center in the brain. The consequence is a
ing, and an important class of bronchodilating drugs total decrease in sympathetic activity in the heart and
acts at bronchiolar beta-adrenergic receptors. blood vessels leading to a reduction in blood pressure.
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780 PART VIII Related Aspects or Cardiopulmonary Physical Therapy
parasympathetic system. It is used to transmit im acid and choline. The acetic acid is washed away for
pulses from the nerve that comes out of the spinal further metabolism, and the choline is reabsorbed into
cord to the nerve that finally reaches the cells in the the nerve terminal for resynthesis to acetylcholine.
organ being affected. This connection is called a gan
glion and exists in both sympathetic and parasympa Cholinergic Drugs
thetic systems. Acetylcholine is also the neurotrans
m i t t e r t h a t m a k e s t h e c o n n e c t i o n b e t w e e n the AcetylchOline
voluntary (somatic) nerves and the skeletal muscle. Acetylcholine is the endogenous cholinergic trans
There are two types of receptors in these systems. mitter that accounts for nicotinic and muscarinic ac
Acetylcholine affects both, but some drugs affect only tions within the autonomic nervous system. It is
one and not the other. The two types of receptors are rapidly hydrolyzed by acetylcholinesterase and the
called nicotinic and muscarinic. They are named after nonspecific cholinesterase and therefore has a short
the drugs that selectively stimulate them. Nicotine duration of action if administered parenterally. This
stimulates only those receptors in the ganglia and at makes acetylcholine (ACh) a poor drug. Nicotinic ef
the neuromuscular junction. The muscarinic receptor fects of acetylcholine are (I) stimulation of parasym
site is found everywhere a parasympathetic nerve ter pathetic ganglia, causing occurrence of all muscarinic
mjnal synapses at a tissue. The biological effects usu effects, (2) stimulation of sympathetic ganglia, caus
ally attributed to the parasympathetic nervous system, ing increase in vascular resistance and cardiac output
such as bradycardia, salivation, and bronchoconstric to produce hypertension, and (3) stimulation of the
tion, for example, are produced when the muscarinic neuromuscular junction (NMJ) at the skeletal muscle
receptors are stimulated. Of course, it is also possible (muscle contraction and movement). Muscarinic ef
to stimulate muscarinic receptors indirectly with a fects of acetylcholine are bradycardia, salivation, pin
nicotinic drug by activating the parasympathetic gan point pupils, bronchial constriction, gastric and in
glia. In fact, in a sirilliar way, it is possible to stimulate testinal hypermotility, increased gastric acid and
the entire sympathetic nervous system. The neuro mucous secretion, and facilitated urination. Toxic ef
transmitter at the sympathetic ganglia is acetylcholine fects of cholinergic stimulation include diarrhea, uri
and it affects nicotinic receptor sites there. One of the nary incontinence, bradycardia, bronchoconstriction,
toxic effects of acetylcholine and drugs that act like it excessive salivation, CNS excitement, and respiratory
is hypertension with tachycardia because of stimula collapse. In all of these toxic effects, atropine, a com
tion of the sympathetic postganglionic fibers. petitive muscarinic blocker, is the antidote of choice.
To better understand the action of acetylcholine
Bethanecol (Urecholine)
and related drugs, let us consider the synthesis, re
lease, and inactivation of this transmitter. Acetyl Bethanecol (Urecholine) is a synthetic choline ester
choline is synthesized inside the nerve terminal from that is not destroyed as easily as acetylcholine by
acetyl-CoA and choline. The acetylcholine is then cholinesterase enzymes. It is useful in treating patients
stored in granules and is released out into the synapse with urinary retention and paralytic ileus, and it is ad
when an action potential reaches the terminal. The ministered orally or subcutaneously. The side effects
acetylcholine molecule attaches to a receptor site, and toxicities for this drug are exactly those for ACh.
muscarinic or nicotinic, or to the enzyme that breaks it However, since the drug is not given intravenously,
apart. Combination with the receptor site results in bi cardiac and respiratory effects are minimized.
ological action, and coupling with the enzyme ends in
Carbachol (Carcholin)
destruction. The enzyme, acetylcholinesterase, is
found at all cholinergic synaptic sites. A nonspecific Carbachol (Carcholin) is a mixed nicotinic and mus
variety of the enzyme is also prevalent in many other carinic drug because it releases acetylcholine from the
tissues. It too will break down acetylcholine. The final nerve ending, producing the expected cholinergic ef
action of either enzyme is the production of acetic fects at all receptor sites. The drug is useful for treat
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43 Respiratory and Cardiovascular Drug Actions 781
ment of glaucoma (applied topically), paralytic ileus, cholinesterase, such as diisopropy lfluorophosphate
and urinary retention (orally and subcutaneously). (DFP) or sarin, is ingested, inhaled, or absorbed
across the skin, a great variety of toxic cholinergic ef
Pilocarpine
fects are seen. The first effects seen after exposure to
Pilocarpine is a cholinomimetic that is useful in oph an anticholinesterase are often ocular and respiratory
thalmology as an antiglaucoma agent. Cholinergic effects. In the eyes, marked miosis is produced
compounds decrease intraocular pressure by relieving quickly. In the respiratory system, bronchoconstric
the obstruction to the canal of Schlemm, a drainage tion and bronchial secretions combine to produce
circuit for the eye. Miosis (pinpoint pupils) is one tightness in the chest and wheezing. Gastrointestinal
feature of cholinergic therapy and may be beneficial symptoms include nausea, vomiting, cramps, and di
to glaucoma treatment because the muscular base of an·hea. Other muscarinic effects are severe salivation,
the relaxed iris may contribute to the drainage block. involuntary defecation and uri nation, swea ting,
Another use of pilocarpine is to promote salivary lacrimation, bradycardia, and hypotension.
flow in patients with a ganglionic blockade. Further effects are related to nicotinic functions of
acetylcholine. These include skeletal muscle twitch
ing, weakness, and paralysis. CNS effects include de
Anticholinesterases
pression of the respiratory and cardiovascular control
Before proceeding to sp ific anticholinesterase drugs, centers, leading to respiratory collapse. At the time of
it is important to understand the basic mechanism of death, respiratory paralysis is evident and it is because
action for these compounds. Acetylcholinesterase is of a combination of bronchoconstriction, bronchose
the enzyme responsible for destroying acetylcholine at cretions, respiratory muscle paralysis from overstimu
the various nerve junctions where it is released. The lation, and CNS and control depression. The treatment
class of drugs that intetfere with this function is called of this toxicity is closely related to preserving respira
anticholinesterascs. These drugs attach to the enzyme tory function. Administration of atropine, a mus
and thereby block the enzymatic hydrolysis of ACh, carinic blocker, will effectively decrease bronchocon
causing ACh to accumulate outside of the nerve end striction and secretion. Another drug, pralidoxime
ing. This results in a greater response than normal to (Pr o t o p am), is u s e d to re a c t i v a t e the a c e t y l
any cholinergic nerve stimulation. Some of these anti cholinesterase. I t i s most effective shortly after expo
cholinesterases are relatively short-acting compounds sure to the toxic agent because it breaks down the an
and are therapeutically impot1ant, whereas others are ticholinesterase so it can be removed from the enzyme
ext.remely long-lasting and potent compounds that are site. Additional measures are related to physiological
important only as poisons. The long-acting compounds suppOt1 of the patient. Maintenance of an airway, arti
have been used as insecticides and as nerve gases in ficial respiration, and oxygen administration are im
chemical warfare. The therapeutically useful anti portant therapeutic applications for these patients.
cholinesterases are beneficial in problems related to
Physostigmine (Eserine)
the eye, intestine, and the skeletal neuromuscular junc
tion (NMJ). In these applications, these drugs increase Physostigmine (Eserine) is useful in glaucoma and in
the amount of ACh available for activity, an effect that selected therapeutic measures where a cholinergic ef
is es ially impOt1ant in cascs where the synthesis or fect is beneficial. It functions as an indirect choli
release of acetylcholine is lower than normal, as in nomimetic by blocking the acetylcholinesterase.
myasthenia gravis.
Neostigmine (Prostigmine)
There is also great medical interest in the toxicol
ogy of the anticholinesterases, especially the ex Neostigmine (Prostigmine) is useful in patients with
tremely potent irreversible anticholinesterases. Toxic nonobstructive paralytic ileus to increase tone and
ity because of these compounds is not uncommon motility of the small and large intestines. It is also
and is often severe. When a toxic irreversible anti useful for stimulating skeletal NMJ. Neostigmine is
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782 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
used for treating gravis because it indi and does not counteract the nicotinic 2:aufllionic ef
increases acetylcholine at the NMJ and it acts fects or the nicotinic effects at the NMJ.
directly at the nicotinic receptor site itself. The dis Because heart rate is controlled both sympathetic
ease is marked by subnormal response t o and parasympathetic tone, atropine will eliminate the
resulting i n skeletal muscle weakness. parasympathetic effect on the heart, the sym
temporarily restores muscle Nrpncrth system to increase heart rate and stroke vol
ume to cause an increase in cardiac output. In
Edrophonium (Tensilson) may occur after atropine administration. In
This a very anticholinesterase. It is pri cases where exists because of high vagal
marily useful as a diagnostic agent in tone, atropine can be used to reverse this depression.
to reveal, for a few minutes, if the dose of In the tract, is a bronchodila
is appropriate. A longer-acting tor. It is also possible to respiratory depression
w o u ld risk a serious c holinergic if t h e associated with tranquilizing, and anti
neostigmine dose was alreadv at the therapeutic limit. cholinesterase drugs atropine, either as a
agent or as an antidote
Atropine is used widely as medica
Cholinergic Blocking Drugs
tion to bronchiolar secretions and laryngeal
antagonists block the various spasm, as well as A more general med
is a transmitter. There are ical use for atropine exists as an emergency tool. It is
for each type of acetylcholine the antidote of choice for all cholinergic toxicities.
receptor. blocks all cholinergic action right One of the most important clinical uses for at
at the muscarinic receptor site on smooth muscle, ex ropine is in the (Ol) tract as an antiul
and myocardium. Another cholinergic cer and agent. This acts to de
curare, works only at the neuromuscular crease in the OI tract so that other antiulcer
to block the nicotinic effect of agents can remain in contact with the OI mucosa
in paralysis of skeletal muscle. Still another and it is possible that it also decreases acid se
type of nicotinic blocker is the blocker, cretion, Other related to hypermotility of
which blocks both sympathetic and the OJ tract are treated with atropine, to de
parasympathetic ganglia occupvinfl the crease muscle activity during treatment of
choline receptor there. These conditions such as cramping and diarrhea.
ever sympathetic or tone needs to be In ophthalmology, is useful for
decreased. It is possible to selectively inhibit cholin which is dilation. It is contraindi
effects in the body to produce a desired effect or cated in glaucoma
to eliminate an undesirable effect. Because of this se an acute attack.
lectiveness, have Atropine itself is also capable of producing toxic
use in many areas of medicine. effects. These are mydriasis, dry
and urinary retention, Effects related to
Atropine the central nervous are also apparent, and
Atropine is an extract from the these include sedation initially, followed by delirium
ladonna, also known as the deadly An and hallucinations, lead to a coma, In severe
other plant extract, scopolamine, has action similar to convulses and severe
atropine, works by establishing a respiratory which may be the final course.
tive at the muscarinic receptor which is Anticholinesterase drugs, such as and
the effector at all tissues innervated the parasym are effective antidotes for atropine be
nervous This blockade is selective cause they increase the amount of acetylcholine that
for the tissue effect of the parasympathetic system will compete with atropine for the rl
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43 Respiratory and Cardiovascular Drug Actions 783
--------� ----- ------ .----
Dicyelomine (Bentyl)
The Carotid Baroreceptors
Dicyclomine (Bentyl) is considered very useful in the
gastrointestinal tract to decrease secretions and motU Neuronal elements, known as baroreceptors, exist in
It is sometimes called a chemical vagotomy, the sinus of the carotid arteries supplying the brain.
These are stretch that fire electrical im
rr;hexyphenidyl HCL (Artane) and
pulses at a rate related to the blood pressure,
Benztropine Mesylate (CogenUn) As the pressure in the the ves:-;el wall
Trihexyphenidyl HCL and me (and stretches, causing an increase in
sylate (Cogentin) are antiparkinson that enter the receptor firing rate. Conversely, a decrease in
the CNS to reverse the imbalance between the cholin blood pressure results in a decrease in stretch receptor
and systems in this disease, They firing rate. This firing rate is sent directly to
have some of the same side effects as the where the vasomotor center and nu
cleus respond to it.
Penlolinium (Ansolysen) and
Hexamethonium (Methium)
The Functional Reflex
Pentolinium (Ansolysen) and hexamethonium (Me
thium) are nicotinic block the To create an this
acetylcholine receptor site in the ganglia in both the let us assume we have experienced a loss of
sympathetic and blood pressure. The carotid shorten and
are used to control slow their This message is then delivered to
to a tonc, Because of their the brain, and the vasomotor center by in
action at the sympathetic ganglion, these drugs pro sympathetic nerve activity, This control al
duce a hypotension. They will also decrease ways to information blood pres
cholinergic effects at the parasympathetic effector sure in the carotid artery by doing the of the
sites because block the for the entire If the pressure had the barore
nervous as well. This means would have increased their rate and the
that a patient may blurred vision, dryness vasomotor center would have responded by slowing
of mouth, and as well as other atropine the sympathetic nerve rate. Since the blood
like peripheral effects. pressure in this example is
increases nerve in in
creased release of norepinephrine from the nerves
THE CARDIOVASCULAR REflEX
that reach the heart and arterioles. Norepinephrine in
The cardiovascular reflex involves many of the com creases the heart rate and stroke volume, thereby pro
ponents of the autonomic nervous system to maintain ducing an increase in cardiac output. In the "rt"rlrllp
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784 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
released from the adrenal medulla also increases car creasing release of histamine, and in a broader ap
diac output. proach, the general stabilization of cells that can re
Meanwhile, the vagal nucleus is responding to the lease mediators of the disease, thereby lowering the
decreased baroreceptor firing by decreasing its own ac severity of the disease.
tivity. The vagus nerve to the heart will release less
acetylcholine, allowing the sympathetic effect to pre Sympathomimetic Drugs
dominate. The total effect becomes an increase in
blood pressure, which is the response required to re Isoproterenol (Isuprel) and
turn the systemic pressure to normal. If the original Epinephrine (Adrenalin)
pressure alteration had been an increase above normal, The muscle relaxant bronchodilator effect attributed to
the opposite reflexive actions would have occurred to the beta-adrenergic sympathomimetic compounds is
return pressure to a normal range. In this case the pre most commonly required for asthmatic or allergic
dominant effect would have been an increase in vagal emergencies. Isoproterenol (Isuprel) is often self-ad
nerve tone, releasing high amounts of acetylcholine at ministered by inhalation to reverse mild-to-moderate
the heart, causing a dramatic slowing of heaJ1 rate, ac obstructive episodes. However, during a severe acute
companied by a decrease in stroke volume. This com obstruction, the airway is unable to pass the drug to the
bination produces a decrease in cardiac output. The alveoli, and the intramuscular or subcutaneous routes
sympathetic system would have responded to the in for epinephrine (adrenaline) and isoproterenol are
creased baroreceptor firing by decreasing firing in all used. Isoproterenol is a purely beta compound. Epi
sympathetic nerves, thereby decreasing norepinephrine nephrine has 50% beta-adrenergic activity and also ex
and epinephrine release. All of these factors combine erts a great bronchodilating effect. Both of these agents
to decrease blood pressure to normal. are useful when given parenterally or by inhalation.
The most common side effects of isoproterenol are
flushing of the skin, headache, palpitation, and tachy
DRUGS USED IN AIRWAY OBSTRUCTIVE DISEASE
cardia. Epinephrine may cause an anxiety reaction in a
Patients suffering from asthma, emphysema, and patient along with headache, palpitations, and respira
chronic bronchitis may have an obstructed airway for tory difficulty. Both drugs can cause serious cardiac
several reasons. Acute asthmatic obstruction and reactions (dysrhythmias), which have resulted in death.
some chronic airway obstruction are due to bronchial
Metaproterenol (Alupent), Isoetharine
smooth muscle contraction, resulting in a smaller di
(with Phenylephrine, Bronkosol-2),
ameter airway. Inflamed passageways, wh ich are
and Salmeterol (Servant)
swollen because of edema, may also constitute an air
way obstruction. A further complication seen in Metaproterenol (Alupent), isoetharine (with Phenyle
many respiratory diseases is the thickening and col phrine, Bronkosol-2), and salmeterol (Servant) are
lection of secretions that cannot be eliminated from isoproterenol analogs that exert most of their action
the respiratory tree and subsequently block the air on respiratory or vascular smooth muscle but have lit
way. In this section the various drugs that can reverse tle effect on the heart. They are useful compounds for
smooth muscle contraction, inflammatory edema, and selectively relaxing bronchial smooth muscles without
collection of secretions are presented. directly affecting the heart. The major advantage of
A variety of therapeutic mechanisms are useful these drugs is that their action on the heart is minimal
against this collection of obstructive conditions. The or absent, and their potential for inducing cardiac toxi
single most effective mechanism for relief of smooth cities is correspondingly reduced. However, because
muscle spasm is the beta2 activity that is available in vascular smooth muscle responds much like respira
some of the adrenergic agents. Other useful mecha tory smooth muscle to these drugs, arterial resistance
nisms aim at potentiating the beta activity of adrener can be decreased, leading to a drop in blood pressure
gic agents, decongesting the inflamed airway, de and a reflexive tachycardia. The beta agonists are
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43 Respiratory and Cardiovascular Drug Actions 785
-... --.--- --�----------------.-----
moderate disease. One of the most common uses for m!m"t",I"V benefit in the at low systemic doses.
aminophylline is the treatment of acute asthmatic air COiticosteroids can be at low doses in alternate
to epinephrine alone. Intravenous administration of this a form that is not systemically absorbed.
drug increases the opportunity for serious side
which are hypotension and cardiac dysrhythmias, Antihistamine
The antiinflammatory steroids are related to the natu Cromolyn sodium (Intal) and nedocromil sodium
glucocorticoid, cortisol (Prednisone, have limited usefulness with the
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786 PART VIII Related Aspects of Cardiopulmonary Physical Therapy
other drugs presented here-they can only prevent an torants that are usually used in mixtures or adminis
asthmatic episode. The mechanism of action is proba tered as cough syrups are ammonium chloride, syrup
bly the stabilization of the mast cell that synthesizes, of ipecac, and glyceryl guaiacolate. These are useful
stores, and releases histamine. Since histamine can for patients who cannot tolerate the iodide salts.
precipitate broncho-obstructive reactions, these drugs
are useful by preventing its release. They are admin
DRUG INHALATION DEVICES
istered by inhalation.
Most drugs given by inhalation in respiratory disease
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43 Respiratory and Cardiovascular Drug Actions 787
1. Why is it important to have an understanding of Clark, TJ.H., Godfrey, S., & Lee, T.H., (Eds.). (1992). Asthm({.
the system a drug is to modify? London: Chapman and Hall.
Hardman, J., Gilman, A.G., Limbird, L., & Rail, T.W., (Eds.).
2. What are the primary and secondary effects of
(1995). The pharmacological basis of therapeutics. New York:
the commonly used bronchodilators, Ventolin McGraw-HilI.
and Alupent? Kaliner, M.A. (1993). How the current understanding of the patho
3. What is the cardiovascular reflex and why is it physiology of asthma influences our approach to therapy. .lour-
important to physical therapists? 1101 afAllergy and Clinical Immunology, 92( I pI. 2), 144-147.
Katzung, B.G., (Ed.). (1995). Basic and clinical pharmacology.
4. What is the pharmacologic rationale for treat
East Norwalk, CT: Appleton & Lange.
ment of patients with chronic obstructive airways O'Brien-Ladner, A. (1994). Asthma: new insights in the manage
disease. (COPD)? ment of older patients. Geriatrics, 49( 11),20-25,30-32.
5. Why is patient compliance with their medica Powell, C.Y. (1993). Management of ac ute asthma in
tions a concern of the physical therapist? ch ildhood.British .lournal ( fHospil{/1 Medicine, 50(5),272-275.
Whelan, A.M., & Hahn, N.W. (1991). Optimizing drug delivery
from metered-dose inhalers. Drug Intelligence and Clinical
Pharmacology, 25, 638-645.
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GLOSSARY
Acid-base balance: a condition existing when the net surgery, gram-negative sepsis, multiple blood
rate at which the body produces acids or bases equals transfusions, oxygen toxicity, trauma, pneumonia, or
the net rate at which acids or bases are excreted. The other respiratory infection.
result of acid-base balance is a stable concentration Aerosol: nebulized particles suspended in a gas or air.
of hydrogen ions in body fluids. The amount of acid Airway clearance: the removal of mucus and foreign
or base in the arterial blood is measured by pH. material from the airways.
Acidosis: a process causing acidemia, which is a Airway-clearance deficits: deficits in the ability to
blood pH of less than 7.38. remove mucus and foreign material from the airways.
Acute exacerbation of chronic airflow Alveolar proteinosis: a disorder marked by the
limitation: an increase in the severity of the signs accumulation of plasma proteins, lipoproteins, and
and symptoms of chronic airflow limitation usually other blood components in the alveoli of the lungs.
triggered by infection, inflammation, or increased The cause is unknown and clinical symptoms vary,
sputum production. although only the lungs are affected. Some patients
Acute lung injury: injury to the lung characterized by are asymptomatic, whereas others show dyspnea and
a clinical spectrum of parenchymal lung dysfunction an unproductive cough.
resulting from multiple etiologies and leading to Alveolar ventilation: the volume of inspired air that
alveolar capillary membrane leaking (high protein reaches the alveolar level and participates in gas
content). Mild-to-moderate lung injury results in exchange, measured by Peo2.
noncardiogenic edema and severe injury results in Alveolitis: an allergic pulmonary reaction to the
adult respiratory distress syndrome. The hallmarks of inhalation of antigenic substances characterized by
worsening lung injury include refractory hypoxemia, acute episodes of dyspnea, cough, sweating, fever,
right-to-left shunt, and reduced lung compliance. weakness, and pain in the joints and mnscles
Adult respiratory distress syndrome (ARDS): a lasting from 12 to 18 hours. Recurrent episodes
respiratory syndrome characterized by respiratory may lead to chronic obstructive lung disease with
insufficiency and hypoxemia. Triggers include weight loss, increasing exertional dyspnea, and
aspiration of a foreign body, cardiopulmonary bypass interstitial fibrosis.
G-1
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G-2 Glossary
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Glossary G-3
structures, and back pain. Most common in adults, it identification of the disorder facilitates the handling
is uften a complication of cystic fibrosis in children. of infants with cerebral palsy and the initiation of an
Treatment includes the cessation of cigarette exercise and training program. Treatment is
smoking, avoidance of airway irritants, the use of individualized and may include the use of braces,
expectorants, and postural drainage. Currently, surgical correction of deformities, speech therapy,
prophylactic antibiotics, steroids, and desensitization and various indicated drugs, such as muscle rel.
À
therapy are not recummended. and anticonvulsants.
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G-4 Glossary
Control of breathing: the central and peripheral constituents of saliva, and overactivity of the
regulation and control mechanisms of breathing. autonomic nervous system. The glands most affected
Control of the heart: the central and peripheral are those in the pancreas, the respiratory system, and
regulation and control mechanisms of the heart. the sweat glands. Because there is no known cure,
Coronary artery disease: any one of the abnonual treatment is directed at the prevention of respiratory
conditions that may affect the arteries of the heart infections, which are the most frequent cause of
and produce various pathological effects, especially death. Mucolytic agents and bronchodilators are used
the reduced flow of oxygen and nutrients to the to help liquefy the thick, tenacious mucus. Physical
myocardium. Any of the coronary artery diseases, therapy measures, such as exercise, postural
such as coronary atherosclerosis, coronary arteritis, drainage, and breathing exercises, can also dislodge
or fibromuscular hyperplasia of the coronary arteries, secretions. Life expectancy in cystic fibrosis has
may produce the common characteristic symptom of improved markedly over the past several decades,
angina pectoris. Studies over the last 30 years and with early diagnosis and treatment, most patients
confirm that coronary atherosclerosis occurs most can be expected to reach adulthood.
frequently in populations with regular diets high in
calories, total fat, saturated fat, cholesterol, and Dead space: the amount of lung in contact with
refined carbohydrates. Other risk factors include ventilating gases but not in contact with pulmonary
cigarette smoking, hypertension, serum cholesterol blood tlow. Alveolar dead space refers to alveoli
levels, coffee intake, alcohol intake, deficiencies of that are ventilated by the pulmonary circulation but
vitamins C and E, water hardness, hypoxia, carbon are not perfused. The condition may exist when
monoxide, social overcrowding, heredity, climate, pulmonary circulation is obstructed, as by a
and viruses. thromboembol.us. Anatomical dead space is an area
Cough: a sudden, audible expulsion of air from the in the trachea, bronchi, and air passages containing
lungs. Coughing is preceded by inspiration, the air that does not reach the alveoli during respiration.
glottis is partially closed, and the accessory muscles As a general rule the volume of air in the
of expiration contract to expel the air forcibly from anatomical dead space in millimeters is
the respiratory passages. Coughing is an essential approximately equal to the weight in pounds of the
protective response that serves to clear the lungs, involved individual. Certain lung disorders, such as
bronchi, or trachea of irritants and secretions or to emphysema, increase the amount of anatomical
prevent aspiration of foreign material into the lungs. dead space. Physiological dead space is an area in
It is a common symptom of diseases of the chest and the respiratory system that includes the anatomical
larynx. Because the function of coughing is to clear dead space together with the space in the alveoli
the respiratory tract of secretions, it is important that occupied by air that does not contribute to the
the cough bring out accumulated debris. Where it oxygen-carbon dioxide exchange.
does not, because of weakness or inhibition of the Denervation of heart: the transplanted heart initially
force of the cough caused by pain, instruction and loses its innervation (i.e., it is deriervated and relies
assistance in effective coughing and deep-breathing on exogenous catecholamines for cardiac
exercises are required. acceleration and deceleration).
Cough pump: the integrated thoracic and abdominal Dependent patients: patients unable to help
mechanisms involved in cough resulting in forced themselves.
expiration and evacuation and clearance of the airways. Depolarization: the changes in ionic concentrations
Cough stages: the stages of cough include maximal across muscle cell membranes leading to contraction
inspiration, closure of the glottis, increased of the cell.
intraabdominal pressure, opening of the glottis, and Diabetes: a clinical condition characterized by the
forced expiration. excessive excretion of urine. The excess may be
Cystic fibrosis: an inherited disorder of the exocrine caused by a deficiency of antidiuretic hormone
glands, causing those glands to produce abnormally (ADH), as in diabetes insipidus, or it may be the
thick secretions of mucus, elevation of sweat polyuria resulting from the hyperglycemia OCCUlTing
electrolytes, increased organic and enzymatic in diabetes mellitus.
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Glossary G-5
Diaphragmatic breathing pattern: involves teaching Endocrine function: the function of the endocrine
patients with CO PO how to relax the accessory glands responsible for normal physiological function.
muscles and to pelform controlled diaphragmatic Evidence-based practice: practice based on evidence
breathing. from the physiologic and scientific literature.
Diflusion: the process in which solid, particulate Exercise: (I) The petformance of any physical
matter in a t1uid moves from an area of higher activity for the purpose of conditioning the body,
concentration to an area of lower concentration, improving health, or maintaining fitness or as a
resulting in an even distribution of the particles in the means of therapy for correcting a deformity or
fluid. No energy is required. restoring the organs and bodily functions to a state of
Documentation: written material associated with the health. (2) Any action, skill, or maneuver that exerts
history, the compilation of laboratory reports and the muscles and is performed repeatedly in order to
investigations, and the results of the clinical develop or strengthen the body or any of its parts.
assessment. (3) To use a muscle or part of the body in a repetitive
Dyspnea: the sensation of difficulty in breathing. way to maintain or develop its strength. The physical
therapist constantly assesses the patient's needs and
ECG monitoring: electrocardiographic monitoring provides the proper type and amount of exercise,
involving electrode placement on the chest wall and taking into account the patient's physical or mental
on the limbs for a 12-lead ECG; such monitoring limitations. Exercise has a beneficial effect on each
provides a tracing of the electrical activity of the of the body systems, although in excess it can lead to
heart. the breakdown of tissue and cause injury.
Echocardiography: evaluation of cardiac structure Exercise blood gases: blood gases taken before,
and function by using the properties of sound. during, and after exercise to determine the effect of
Quantitative and qualitative measurements can be exercise on oxygen transport.
derived. The most common types include two Exercise stress: the physical stress imposed by
dimensional, Doppler, and transesophageal echoes. movement (i.e., mobilization and exercise.)
Ejection fraction: a measure of myocardial function, Expiratory reserve volume (ERV): the maximum
it is the amount of ventricular volume ejected with volume of gas that can be expired from the resting
each heart beat. Expressed as a percent, the ejection expiratory level.
fraction = (end-diastolic volume - end-systolic Extrinsic factors: factors related to the patient's care
volume) x 100 end-diastolic volume. that contribute to cardiopulmonary dysfunction and
Electrocardiogram (ECG): the tracing produced by impaired gas exchange.
the sequential depolarization and repolarization of
myocardial cells as detected by sutface electrodes Fluid and electrolyte status: the status of blood
placed on the skin. volume and distribution, and the status of electrolyte
Electromechanical coupling: the coupling of balance in the body; fluid balance often has a direct
electrical and mechanical events of the heart to effect effect on electrolytes.
cardiac output. Forced expiratory volume in one second (FEV I): the
EMG power spectrum: electromyography is the amount of air expired in I second during a forced
process of recording the electrical activity of muscle exhalation after a maximal inhalation.
on a cathode-ray oscilloscope. The Forced vital capacity (FVC): the total amount of air
electromyographic (EMG) power spectrum is the full exhaled during a forced exhalation after a maximal
range of electrical activity of the muscle. inhalation.
Emphysema: a lung condition characterized by an Functional residual capacity: the volume of gas in
abnormal permanent enlargement of the air spaces the lungs at the end of a normal expiration. The
distal to the terminal bronchioles, accompanied by functional residual capacity is equal to the residual
destruction of their walls. volume plus the expiratory reserve volume.
Endocardial cushion defect: any cardiac defect Function optimization: optimal functioning of the
resulting from the failure of the endocardial cushions in patient as a whole person based on optimal
the embryonic heart to fuse and form the atrial septum. physiological functioning at an organ system level.
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G-6 Glossary
Gas exchange: the movement of oxygen and carbon temperature. The percentage is usually represented in
dioxide between the pulmonary capillary blood and terms of relative humidity, with 100% being the
the alveolar tissue and between the systemic capillary point of air saturation or the level at which the air can
blood and peripheral tissue cells. absorb no additional water.
Gastrointestinal dysfunction: abnormal function of Hyaline membrane disease: disease of the newborn,
the gastrointestinal system. characterized by airless alveoli, inelastic lungs, more
Gravitational stress: stress imposed on the human than 60 respirations a minute, nasal flaring,
body by gravity and its physiological effects. intercostal and subcostal retractions, grunting on
Gravity: the heaviness or weight of an object resulting expiration, and peripheral edema. The condition
from the universal effect of the attraction between any occurs most often in premature babies. The disease is
body of matter and any planetary body. The force of self-limited; the infant dies in 3 to 5 days or
the attraction depends on the relative masses of the completely recovers with no after-effects. Treatment
bodies and on the distance between them. includes measures to corTect shock, acidosis, and
hypoxemia and use of positive airway pressure to
Head injury: any traumatic damage to the head prevent alveolar collapse. This is also called
resulting from blunt or penetrating trauma of the respiratory distress syndrome (RDS) olthe newborn.
skull. Blood vessels, nerves, and meninges can be Hypercapnia: the presence of an abnormally large
torn; bleeding, edema, and ischemia may result. amount of carbon dioxide in the circulating blood.
Health behavior: an action taken by a person to Hyperpnea: rapid shallow breathing.
maintain, attain, or regain good health and to prevent Hypertension: a common, often asymptomatic
illness. Health behavior reflects a person's health disorder characterized by elevated blood pressure
beliefs. Some common health behaviors are persistently exceeding 140/90 mm Hg. Patients with
exercising regularly, eating a balanced diet, and high blood pressure are advised to follow a low
obtaining necessary inoculations. sodium, low-saturated-fat diet, to reduce calories to
Heart: the muscular, cone-shaped organ, about the control obesity, to exercise, to avoid stress, and to
size of a clenched fist, that pumps blood throughout take adequate rest.
the body and beats normally about 70 times per Hypoxemia: a low level of oxygen in the blood, often
minute by coordinated nerve impulses and muscular characterized by a Pa02 of less than 80 mm Hg.
contractions. Enclosed in pericardium, the heart rests
on the diaphragm between the lower borders of the Immune function: function of the immunological
lungs, occupying the middle of the mediastinum. The system and its components in effecting optimal
sinoatrial node of the heartbeat sets the rate. Other immunological protection.
factors affecting the heartbeat are emotion, exercise, Immunological dysfunction: abnormal function of
hormones, temperature, pain, and stress. the immunological system.
Heart-lung interdependence: the heart and lung are Immunosuppression: of or peI1.aining to a suhstance or
structurally and functionally interdependent and form procedure that lessens or prevents an immune response.
a cardiopulmonary unit. Inspiratory capacity (Ie): the maximum volume of
Hemiplegia: paralysis of one side of the body. gas that can be inhaled from the resting expiratory
Hemodynamic status: status of the heart and its level. Equal to the sum of the tidal volume and the
capacity to effect blood movement to perfuse the inspiratory reserve volume, it is measured with a
tissues of the body. spirometer.
Hibernating myocardium: contractile dysfunction of Inspiratory muscle training: resistance ventilatory
the myocardium as a result of prolonged ischemia, training designed to increase the strength and
appearing as a regional wall motion abnormality. endurance of the inspiratory muscles.
Home care: a health service provided in the patient's Inspiratory resistance breathing: a method of
place of residence for the purposes of promoting, respiratory muscle training that includes normal
maintaining, or restoring health or minimizing the ventilation with added external threshold loading
effects of illness and disability. on inspiration consisting of 15 to 30 minutes of
Humidity: pertaining to the level of moisture in the training 5 days per week. External loading is
atmosphere, the amount varying with the increased from 30% of maximal inspiratory pressure
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Glossary G-7
to 60% of maximal inspiratory pressure as patient's nephrons. All the blood in the body passes through
tolerance increases. the kidneys about 20 times every hour but only about
Inspiratory reserve volume: The maximum volume one fifth of the plasma is filtered by the nephrons
of gas that can be inspired from the end-tidal during that period. The kidneys remove water as
inspiratory level. urine and return water that has been filtered to the
Intermittent positive pressure breathing (IPPB): a blood plasma, thus helping to maintain the water
form of assistive or controll.ed respiration produced baJance of the body. Hormone, especially the
by a ventilatory apparatus in which compressed gas antidiuretic hormone (ADH), produced by the
is delivered under positive pressure into the person's pituitary gland, control the function of the kidneys in
airways unti I a preset pressure is reached. Passi ve regulating the water content of the body.
exhalation is allowed through a valve, and the cycle Kyphoscoliosis: an abnormal condition characterized
begins again as the flow of gas is triggered by by an anteroposterior curvature and a lateral
inhalation. This is also called i11lermillent positive curvature of the spine. It occurs in children and
pressure ventilation (IPPV). adults and can be associated with cor pulmonale.
Interstitial pulmonary fibrosis: a classification of
restrictive lung disease including conditions that Late sequelae of poliomyelitis: the late effects of
result in a final common pathway of bouts of chronic poliomyelitis that may occur in poliomyelitis
lung infection and irreversible fibrosis. survivors 30 to 35 years after onset. These effects
Intraaortic balloon counter pulsation: procedure for include disproportionate fatigue, weakness, pain,
assisting left ventricular function and coronary reduced endurance, choking and swallowing
petfusion involving the insertion of a balloon in the problems, altered temperature sensitivity, and
femoral artery. The inflation and deflation of the psychological problems.
balloon is synchronized with the ECG such that it Learning theory: a group of concepts and principles
inflates during diastole and deflates during systole. that attempts to explain the learning process. One
Intracardiac pressures: pressures within the concept, Guthrie's contiguous conditioning premise,
chambers of the heart. Optimal movement of blood postulates that each response becomes permanently
through the heart depends on pressure gradients linked with stimuli present at the time so that
throughoLlt the heart. Normal pressures within each contiguity rather than reinforcement is a part of the
heart chamber are within a restricted range. learning process.
Intracranial pressure monitoring: invasive Liver: the largest gland of the body and one of its
monitoring instituted to measure changes in cranial most complex organs. More than 500 of its functions
pressure usually resulting from increased volume of have been identified. It is divided into four lobes,
the brain because of injury. bleeding, fluid contains as many as 100,000 lobules, and is served
accumulation, or an intracranial mass. by two distinct blood supplies. Some of the major
Isocapnic hyperpnea: a method of respiratory muscle functions performed by the liver are the production
training that includes high ventilation with low of bile by hepatic cells, the secretion of glucose,
external loading consisting of sustained periods of proteins, vitamins, fats, and most of the other
hyperpnea lasting 15 to 30 minutes daily for several compounds used by the body, the processing of
weeks with the addition of carbon dioxide to hemoglobin for vital use of its iron content, and the
maintain a normal level. conversion of poisonous ammonia to area.
Lung cancer: a pulmonary malignancy attributable to
Jacobsen's progressive relaxation exercise: a cigarette smoking in 50% of cases. Lung cancer
technique involving contraction followed by develops most often in scalTed or chronically diseased
relaxation to progressively relax muscle groups. lungs and is usual.
because metastases may precede the detection of the
Kidneys: a pair of bean-shaped urinary organs in the primary lesion in the lung. Symptoms of lung cancer
dorsal part of the abdomen, one on each side of the include persistent cough, dyspnea, purulent or blood
vertebral column. The kidneys produce and eliminate streaked sputum, chest pain, and repeated attacks of
urine through a complex filtration network and bronchitis or pneumonia. Surgery is the most
reabsorption system comprising more than 2 million effective treatment, but only one half of cases are
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G-8 Glossary
operahle at the time of diagnosis and of these 50% are Metabolical demand fluctuates depending on the
not resectable. Thoracotomy is contraindicated if activity level of the individual, the presence of illness
metastases are found in contralateral or scalene lymph and increascd temperature, and the requirements of
nodes. In"adiation is used to treat localized lesions and healing and repair.
unresectable intrathoracic tumors and as palliative Method: a technique or procedure for producing a
therapy for metastatic lesions. Radiotherapy may also desired effect, such as a surgical procedure, a
be administered after surgery to destroy remaining laboratory test, or a diagnostic technique.
tumor cells and may be combined with chemotherapy. Minute ventilation (VE): the amount of air inspired
Lung capacities: lung volumes that consist of two or in I minute. It is the product of tidal volume and
more of the four primary nonoveriapping volumes. respiratory rate.
Functional residual capacity is the sum of residual Minute ventilation: the total expired volume of air
volume and expiratory reserve volume. Inspiratory per minute.
capacity is the sum of the tidal volume and Mobilization: the therapeutic and prescriptive
inspiratory reserve volume. Vital capacity is the sum application of low-intensity exercise in the
of the expiratory reserve volume, the tidal volume, management of cardiopulmonary dysfunction usually
and the inspiratory reserve volume. Total lung in acutely ill patients. The primary goal of
capacity, at the end of maximal inspiration, is the mobilization is to exploit the acute eflects or exercise
sum of the functional residual capacity and the to optimize oxygen transport.
inspiratory capacity. Morbid obesity: an excess of body fat that threatens
Lung compliance: the volume change per unit of normal body functions, such as respiration.
pressure change in the lungs. Mucous blanket: the normal layer of mucous lining
Lungs: a pair of light, spongy organs in the thorax, the bronchopulmonary tree. This blanket provides a
constituting the main component of the respiratory medium through which foreign material and bacteria
system. The two highly elastic lungs are the main can be wafted centrally by the cilia for eventual
mechanisms in the body for inspiring air from which removal by coughing or swallowing.
oxygen is extracted for the arterial blood system and Multiple sclerosis (MS): a progressi ve discase
for exhaling carbon dioxide dispersed from the characterized by disscminated demyelination of
venous system. nerve fibers of the brain and spinal cord. It begins
Lung volume: the volume of the lungs that may be slowly, usually in young adulthood, and continues
compartmentalized into component volumes and throughout life with periods of exacerbation and
capacities. remission. As the disease progresses, the intervals
between exacerbations grow shorter and disabil ity
Malnutrition: any disorder of nutrition. It may result becomes greater. There is no specific treatment for
from an unbalanced, insufficient, or excessive diet or the diseasc; corticosteroids and other drugs are
from the impaired absorption, assimilation, or use of used to treat the symptoms accompanying acute
foods. episodes. Physical therapy may help to postpone
Managed care: a health care system in which there is or prevent specific disabilities. The patient is
administrative control over primary health care encouraged to live as normal and active a life
services in a medical group practice. Redundant as possible.
facilities and services are eliminated and costs are Multisystem assessment: the assessment of
reduced. Health education and preventive medicine multiple organ systems based on clinical examination
are emphasized. Patients may pay a flat fee for basic and investigative laboratory reports. Such assessment
family care but may be charged additional fees for helps identify all factors that contribute to deficits in
secondary care services of specialists. oxygen transport.
Measurement: the determination, expressed Muscle endurance: the ability to sustain repetitive
numerically, of the extent or quantity of a substance, contraction against a given load.
energy, or time. Muscle strength: the maximum force that a muscle
Mechanical ventilation: the use of artificial can develop with maximal stimulation.
mechanical means to support ventilation. Muscular dystrophy (MD): a group of genetically
Metabolical demand: the energy and oxygen transmitted diseases characterized by progressive
demands of the body required to support metabolism. atrophy of symmetrical groups of skeletal muscles
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Glossary G-9
without evidence of involvement or degeneration of Oxygen (02): a tasteless, odorless, colorless gas
neural tissue. [n all forms of muscular dystrophy, essential for human respiration.
there is an insidious loss of strength with increasing Oxygen consumption (Vo2): the difference between
disability and deformity, although each type differs oxygen that is inspired and the amount of oxygen
in the groups of muscles affected, the age of onset, exhaJed. The difference between inspired and expired
the rate of progression, and the mode of genetic oxygen is a primary measure of aerobic fitness.
inheritance. The basic cause is unknown but appears Oxygen delivery (Do2): the delivery of oxygen to the
to be an inborn error of metabolism. Treatment of the tissues of the body. an essential component of
muscular dystrophies consists primarily of supportive oxygen transport.
measures, such as physical therapy and orthopedic Oxygen desaturation: the desaturation of oxygen
procedures to minimize deformity. from the hemoglobin molecule in the blood in
Myocardial infarction: necrosis of a portion of response to a reduction of tissue oxygen levels.
cardiac muscle caused by obstruction in a coronary Oxygen transport: the process by which oxygen is
artery from either atherosclerosis or an embolus. absorbed in the lungs by the hemoglobin in
Also called a heart attack. circulating deoxygenated red cells and carried to the
peripheral tissues. The process is made possible
Needs assessment: assessment of the patient's specific because hemoglobin has the ability to combine with
physical, functional, and psychological needs. oxygen present at a high concentration, such as in the
Nocturnal ventilation: the selective use of lungs, and to release this oxygen when the
mcchanical ventilation during the night. Patients with concentration is low, such as in the peripheral tissues.
cardiopulmonary dysfunction are at greater risk Oxygen transport pathway: the pathway for oxygcn
during the night when they are recumbent and the delivery to the tissues from the ambient air, through
respiratory drive is depressed. the airways and lungs, across the alveolar capillary
membrane, into the pulmonary circulation through
Obesity: an abnormal increase in the proportion of fat the chambers of the heart, via the peripheral and
cells. mainly in the viscera and subcutaneous tissues regional circulation to the tissues and the
of the body. Obesity may be exogenous or mitochondria where oxygen is used in cellular
endogenous. Hyperplastic obesity is caused by an respiration.
incrcase in the number of fat cells in the increased Oxygen saturation: a measurement of the amount of
adipose tissue mass. Hypertrophic obesity results oxygen attached to a hemoglobin molecule.
from an increase in the size of the fat cells in the Oxyhemoglobin dissociation: the dissociation of
increase adipose tissue mass. oxygen from the hemoglobin molecule in peripheral
Objective: (I) A goal. (2) Of or pertaining to a tissues when the concentration of oxygen is low.
phenomenon or clinical finding that is observed; not
subjective. An objective finding is often described in Parenchyma: the tissue of an organ as distinguished
health care as a sign, as distinguished from a from supporting or connective tissue.
symptom, which is a subjcctive finding. Parkinson's disease: a slowly progressive,
Obstructive lung disease: a classification of lung degenerative, neurological disorder characterized by
disease referring to airflow limitation secondary to resting tremor, pill rolling of the fingers, a masklike
obstruction and increased airway resistance (e.g., expression, shuffling gait, forward flexion of the
chronic bronchitis and emphysema). trunk, loss of postural reflexes, and muscle rigidity
Osteoporosis: a disorder characterized by abnormal and weakness. It is usually an idiopathic disease of
rarefaction of bone, occurring most frequently in people over 60 years of age, although it may occur in
postmenopausal women, in sedentary or immobilized younger people, especially after acute encephalitis or
individuals, and in patients on long-term steroid carbon monoxide or metallic poisoning, particularly
therapy. The disorder may cause pain, especially in by reserpine or phenothiazine drugs.
the lower back, pathological fractures, loss of stature, Partial pressure of gases: the pressure exerted by an
and various deformities. individual gas, a percent of the total pressure of gases.
Outpatient: a patient, not hospitalized, who is being Patent ductus arteriosus (PDA): an abnormal
treated in an olTiec, clinic, or other ambulatory care opening between the pulmonary artery and the aorta
facility. caused by failure of the fetal ductus arteriosus to
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G-10 Glossary
close after birth. The defect, which is seen primarily Prevention: any action directed toward preventing
in premature infants, allows blood from the aorta to illness and promoting health to avoid the need for
flow into the pulmonary artery and to recirculate secondary or tertiary health care.
through the lungs, where it is reoxygenated and Primary cardiopulmonary dysfunction:
returned to the left atrium and left ventricle, causing cardiopulmonary dysfunction resulting from a primary
an increased workload on the left side of the heart condition of the heart, lungs, or both.
and increased pulmonary vascular congestion and Pulmonary rehabilitation: rehabilitation of
resistance. cardiopulmonary dysfunction including the acute,
Pediatric cardiac rehabilitation: specialized cardiac subacute, and chronic phases of the disease or after
rehabilitation for children instituted in the chronic thoracic surgery. The long-term management
stage of heart disease or after cardiovascular surgery includes a comprehensive program of exercise,
when the patient is through the acute phase. ventilatory support, additional airway clearance
Pediatric pulmonary rehabilitation: specialized interventions as needed, nutrition, stress reduction,
pulmonary rehabilitation for children instituted in the smoking cessation, pacing and energy
subacute or chronic stages of lung disease or after conservation, vocational rehabilitation, sexual
thoracic surgery when the patient is through the acute rehabilitation, and education.
phase. Pulmonary development: the anatomical and
Perfusion: the passage of a fluid through a specific physiological development of the cardiopulmonary
organ or an area of the body. system during nom1al growth and development.
Perioperative complications: complications before, Pulmonary circulation: the blood flow through a
during, and after surgery. network of vessels between the heart and the lungs
Peripheral circulation: the systemic circulation, for the oxygenation of blood and removal of carbon
which excludes the circulation to the heart and lungs dioxide.
(the central circulation).
Peripheral vascular disease: any abnormal condition Quality care: the provision of holistic care in which
that affects the blood vessels outside the heart and the needs and wants of the patient are considered.
the lymphatic vessels.
Pneumonia: an acute inflammation of the lungs, Recumbency: the state of lying down or leaning
usually caused by inhaled pneumococci of the against something.
species Streptococcus pneumoniae. The alveoli and Reflex cough: a cough stimulated reflexively.
bronchioles of the lungs become plugged with a Reliability: the extent to which a test measurement or
fibrous exudate. Pneumonia may be caused by a device produces the same results with different
other bacteria, as well as by viruses, rickettsiae, investigators, observers, or administration of the test
and fungi. over time. If repeated use of the same measurement
Positron emission scans: tomographic scans using tool on the same sample produces the same consistent
positron emitting radionuclides. The tracers used are results, the measurement is considered reliable.
often taken up in the metabolical pathways of the Residual volume: the volume of air remaining in the
tissues being studied (e.g., oxygen metabolism or lung after a maximal expiration.
gluclose metabolism). Resources: services, personnel, and treatment options
Prescription: an order for medication, therapy, or a that can be drawn on to maximize treatment delivery
therapeutic device given by a properly authorized and effectiveness.
person to a person properly authorized to dispense or Respiratory muscle fatigue: a loss in the capacity of
perform the order. A prescription is usually in written a muscle underload to develop force or velocity that
form and includes the name and address of the is reversible by rest.
patient, the date, the [4]+ symbol (superscription), Respiratory muscles: the muscles that produce
the medication prescribed (inscription), directions to volume changes of the thorax during breathing. The
the pharmacist or other dispenser (subscription), inspiratory muscles include the hemidiaphragms,
directions to the patient that must appear on the label, external intercostals, scaleni, sternomastoids,
the prescriber's signature, and, in some instances, an trapezius, pectoralis major, pectoralis minor,
identifying number. subclavius, latissimus dorsi, serratus anterior, and
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Glossary G-11
muscles that extend the back. The expiratory muscles Sclerodenna: a relatively rare autoiuunune disease
are the external intercostals, abdominals, and the affecting the blood vessels and connective tissue. The
muscles that flex the back. disease is chaJ'acterized by fibrous degeneration of lhe
Respirator), muscle weakness: a chronic loss in the connective tissue of the skin, lungs, and intemal organs,
capacity of a rested muscle to generate force. especially the esophagus, digestive tract, and kidneys.
Respiratory mechanics: the physical properties of Scleroderma is most common in middle-aged women.
the lung including resistance and compliance Secretion management: management of airway
characteristics. secretions.
Respiratory failure: the inability of the cardiac and Sedation: an induced state of quiet, calmness, or sleep,
pulmonary systems to maintain an adequate as by means of a sedative or hypnotic medication.
exchange of oxygen and carbon dioxide in the lungs. Sepsis and multiorgan system failure: overwhelming
Respiratory failure may be oxygenation or systemic infection and pathogens leading to failure
hypcrcapniac. Treatment of respiratory fai lure within multiple organ systems.
includes maximizing ventilation, clearing the airways Shock: an abnormal condition of inadequate blood
by suction, bronchodilators, or tracheostomy, flow to the body s peripheral tissues, with life
antibiotics for infections usually present, threatening cellular dysfunction, hypotension, and
anticoagulants for pulmonary thromboemboli, and oliguria. The condition is usually associated with
electrolyte replacement in fluid imbalance. Oxygen inadequate cardiac output, changes in peripheral
may be administered in some cases; in others it may blood flow resistance and distribution, and tissue
further decrease the respiratory reflex by removing damage. Causal factors include hemorrhage,
the stimulus of a decreased elevated level of oxygen. vomiting, diarrhea, inadequate fluid intake, or
Restrictive lung disease: a category of lung disease excessive renal loss, resulting in hypovolemia.
involving restriction of the lung parenchyma and Skilled nursing and rehabilitation facilities: an
characterized by stiffness (reduced compliance) and institution or part of an institution that meets criteria
reduced lung volume. for accreditation established by the sections of the
Rheumatoid arthritis: a chronic, destructive, sometimes Social Security Act that determine the basis for
deforming collagen disease that has an autoimmune Medicaid and Medicare reimbursement for skilled
component. Rheumatoid aJthritis is characterized by nursing care, including rehabilitation and various
symmetric inflammation of the synovium and increased medical and nursing procedures.
synovial exudate, leading to thickening of the synovium Spinal cord injury: any one of the traumatic
and swelling of the joint. Rheumatoid arthritis usually disruptions of the spinal cord, often associated with
first appears in early middle age, between 36 and 50 extensive musculoskeletal involvement. Common
years of age, and most commonly in women. The spinal cord injuries are vertebral fractures and
course of the disease is variable but is frequently dislocations, such as those commonly suffered by
marked by remissions and exacerbation. individuals involved in car accidents, airplane
Risk factors: factors that cause a person or a group of crashes, or other violent impacts. Such trauma may
people to be particularly vulnerable to an unwanted, cause varying degrees of paraplegia and
unpleasant, or unhealthful event, such as quadriplegia. Treatment of spinal cord injuries varies
immunosuppression, which increases the incidence considerably and involves numerous approaches,
and severity of infection, or cigarette smoking, which such as exercise, ambulatory techniques, and special
increases the risk of developing a respiratory or physical and psychological therapy.
cardiovascular disease. Stable angina: anginal pain that is well-controlled,
Routine body positioning: the routine use of body medically stable, and has a predictable
positioning in the management of patients to activity/exercise threshold.
minimize the negative effects of static positioning Status asthmaticus: an acute, severe, and prolonged
and maximize comfort. The purposes of routine body asthma attack. Hypoxia, cyanosis, and
positioning are distinct from the specific goals of unconsciousness may follow. Treatment includes
prescriptive body positioning, which are related to bronchodilators given intravenously or by aerosol
optimizing particular components of inhalation, corticosteroids, controlled positive
cardiopulmonary function and gas exchange. pressure ventilation, sedation, frequent therapy,
Copyrighted Material
G-12 Glossary
and emotional support. A bronchodilator may be myocardium based on perfusion of the area. This
given by aerosol inhalation from a ventilator. agent can be used for rest studies, exercise stress
Stroke volume (SV): the amount of blood ejected studies, and pharmacological stress studies.
from the ventricles during systole. Thoracic cavity: the cavity enclosed by the ribs, the
Stunned myocardium: contractile dysfunction of the thoracic portion of the vertebral column, the sternum,
myocardium as a result of an acute episode of the diaphragm, and associated muscles.
ischemia that persists even after perfusion has Thoracic surgery: the branch of medicine that deals
returned to normal. with disease and injuries of the thoracic area by
Subacute hospitals: hospitals that specialize in the manipulative and operative methods.
management of nonacute conditions. Throat clearing: the spontaneous elicitation of a
Subjective: (I) Pertaining to the essential nature of an coughlike maneuver to clear secretions or an
object as perceived in the mind rather than to a thing obstruction from the oropharynx that may be
in itself. (2) Existing only in the mind. (3) That threatening the upper airway.
which arises within or is perceived by the individual, Tidal volume (TV): the amount of air inhaled and
as contrasted with something that is modified by exhaled during normal ventilation. Inspiratory
external circumstances or something that may be reserve volume, expiratory reserve volume, and tidal
evaluated by objective standards. volume make up vital capacity.
Suctioning: the use of mechanical airway suctioning Total lung capacity (TLC): the volume of gas in the
that uses a catheter and negative pressure to remove lungs at the end of a maximum inspiration. It equals
oropharyngeal or airway secretions when the patient the vital capacity plus the residual capacity.
is unable to spontaneously or voluntarily take deep Tracheobronchial tree (TBT): an anatomic complex
breaths and cough effectively. that includes the trachea, the bronchi, and the
Supraventricular: pertaining to a feature or event bronchial tubes. It conveys air to and from the lungs.
occurring superior to the ventricles of the heart. Tracheostomy: an opening through the neck into the
Surgery: the branch of medicine concerned with trachea through which an indwelling tube may be
diseases and trauma requiring operative procedures. inserted.
Syncytium: the arrangement of cells, as in the Tracheostomy tube/cuff: a tube/cuff that is
myocardium, such that stimulation of one cell causes positioned directly through the trachea in the neck to
stimulation of adjacent cells, thus causing an action provide a functioning airway that bypasses the nares
potential to spread from the initial focus. and oropharynx.
Systemic disease: dysfunction or condition affecting Transitional care units: settings that specialize in
one or more systems. providing care between the acute, subacute, and
Systemic lupus erythematosus (SLE): a chronic long-term stages of a patient's illness.
inflammatory disease affecting many systems of the Transitional circulation: a transition from one type
body. The pathophysiology of the disease includes of blood vessel to another on moving peripherally
severe vasculitis, renal involvement, and lesions of through the circulation.
the skin and nervous system. The primary cause of Treatment selection and prioritization: the process
the disease has not been determined; viral infection of selecting treatments and then prioriti7.ing the order
or dysfunction of the immune system has been in which these treatments are administered. This
suggested. Adverse reaction to certain drugs also process is based on the relati ve contribution of the
may cause a lupus like syndrome. SLE occurs four pathogenesis that each treatment addresses with
times more often in women than in men. respect to oxygen transport deficiencies.
Trunk-ventilation interaction: the interrelationship of
Tachycardia: an abnormally rapid heart rate. the shape and movement of the trunk or chest wall on
Tachypnea: an increased respiratory rate over 20 alveolar ventilation. Trunk and ventilation interaction
breaths per minute. depends on body positioning and movement.
Thallium-20l scan: a radionuclide scan that evaluates Tuberculosis: a chromic granulomatous infection
myocardial perfusion. The tracer is taken up in the callsed by an acid-fast baci Ilus, mycobacterium
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Glossary G-13
tuberculosis, generally transmilled by the inhalation with high, intermediate, or low probability of
or ingestion or infected droplets and usually affecting pulmonary embolus.
the lungs, although infection of multiple organ Ventilation and perfusion matching: the matching
systems occurs . of ventilation and perfusion in the lungs. Optimal
Type I fibers: a type of skeletal muscle fiber that is ventilation and perfusion matching occurs in the
also called slow-twitch and is suitable for sustained mid zones of the upright lung where the ratio is
tonic activity (e.g., the maintenance of posture or 0.8 to 1.0.
breathing, which require resistance to fatigue). Vital capacity (Ve): a measurement of the amount of
Type IlA fibers: a type of skeletal muscle fiber that is air that can be expelled at the normal rate of
also called fast-twitch; this type of fiber is used for exhalation after a maximum inspiration, representing
short-term, fast, powerful activity in which the greatest possible breathing capacity. The vital
endurance to fatigue is not required. capacity equals the inspiratory reserve volume plus
the tidal volume plus the expiratory reserve volume.
Validity: the extent to which a test measurement or The average normal values of 4000 to 5000 ml are
other kind of device measures what il is intended affected by age, physical dimensions of the chest
to measure. cage, posture, and gender. The vital capacity may be
Valvular heart disease: an acquired or congenital reduced by a decrease in functioning lung tissue,
disorder of a cardiac valve, characterized by stenosis resulting from atelectasis, edema, fibrosis,
and obstructed blood flow or by valvular pneumonia, pulmonary resection, or tumors; by
degeneration and regurgitation of blood. limited chest expansion, resulting from ascites, chest
Ventilation: the process by which gases are moved deformity neuromuscular disease, pneumothorax, or
into and out of the lungs. pregnancy; or by airway obstruction.
Ventilatory strategies: teaching patients to control
breathing with the utilization of ventilatory patterns Work of breathing: the total amount of effort
(e.g., combining inspiration with trunk extension and required to expand and contract the lungs; the
exhalation with trunk l1exion). physiological "cost" of breathing. Generally, quiet
Ventilation-perfusion scan: two scans which are breathing consumes 2% to 3% of the oxygen
used to assess patients for the presence of consumption and requires 10% of the vital capacity.
pulmonary emboli. Criteria (BIELLO or PIOPED) If a greater amount is used, one would say the work
are used to determine if matched defects present of breathing is increased.
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I N D E X
A bronchiOlitis, 477
bronchitis, 476--477
Abscesses
chronic airflow limitation, 478--481
radiography of, 164, 164
emphysema, 478--481
hypertension, 488
pneumonias, 472--476
tuberculosis, 487--488
techniques (ACT)
thoracic, 500--502
Acute medical conditions, primary dysfunction secondary to,
AD; see Autogenic drainage (AD)
469-492
alveolitis, 477-478
angina, 488-490
asthma, 481-483
i
Adenosinetriphosphatase pump, tha lium 20 I'and, "200--20 I
atelectasis, 470--472,471
1-1
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1-2 Index
Adrenal runetion
co stoph renic, 373, 373-374
Adult respiratory distress syndrome (ARDS); see also Respiratory long silting self, 379, 379-380, 380
Airway clearance techniques (ACT) Airway p re s sure release v e ntila t i o n (APR V), defined, 758
effectiveness, 362
for plasma volume, 234
percussion, 344-346,345
Alternative long-term care facilities; see Long-term care facilities
selection of,361,361
Alveolar proteinosis
support, 362-363
management of, 478
utilization of,340
pathophysiology of,86, 86-87,478
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Index 1-3
Ambient air, oxygen transport and, 15-16 chronic secondary dysfunction and
threats/treatment, 261 management of, 558
Aminoglycusides, intensive care and, 579,580t,581 pathophysiology of, 557-558
Aminophylline, pharmacology of, 785 Anorexia nervosa, cardiopulmonary effects 0 1', 1 10-11 1 , II I
Amphctnminc (Dextroilmphetamine, Dexedrine), pharmacology ANS; see Automatic nervous system (ANS)
uL 77R Anterior chest compression, 375, 375
Amylase, lahoratory tcsts of, 193t, 193-194, 194t Antianginal agents, for reus, 572-573
Anaerobic Illcwh"lism. in oxygen transport, 6-8, 10-11. 13 Anticholinesterases, pharmacology of, 781
Analgesic Antihistamines, corticosteroids and, 785-786
for leUs, 572-573 Antiinflammatory agents
fur oxygen transport treatment 259-260, 260 for oxygen transport treatment, 259-260, 260
Anaphylactic rc·actions. trcatment of.777 treatment with, 784
Anatomy Anxiety, oxygen transport threats and, 255
bronchopulmonary segment, 4 I, 42t, 43. 44 Aortic volume, cardiopulmonary physiology of, 66, 66
canliupulmonary.2-'-50 Apnea
circulation. 48--50 cardiopulmonary effects of, 109
heart. 44-4R,45,46,47,48 patient asseSSlnents for, 216
fetal,6Je) respiratory failure and, 579, 580t, 581
lungs.40-A4. 41. 42t, 43 Appearance, patient assessments and, 212-213
lymphatic circulation, 50 APRY; see Airway pressure release ventilation CAPRY)
muscle" 26--40 Arrhythmias
diaphragm, 26, 2li28. 27, 28 electrocardiograms and, 177, 178, [79-184,179-184
erector spi nac 30. 3 I
, supraventricular. 177, 178, 179,179,180,181
expiration, 27. 31-32 ventricular, 180-184, 182, [83, 184
inspiration, 26 intensive care of, 236, 236t, 239
intercostal>. 2R, 29 pathophysiology of, 91-92
larynx. 35. 1536 Arsenic, respiratory failure and, 579, 580t,581
lower airways. 36--40, 37,39t Arterial blood gase s 153-157
,
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1-4 Index
Bacterial pneumonias
gases, arterial
Barrel chest, patient assessments for, 214-2 I 6,216
Bed rest
Asthma
chronic primary
hazards of, 293
pathophysiology of,S I 9
as therapy, 291-292
pediatric, 642-M3
primary/ICU, 589-59 I
Blood
pathophysiology of, 589
desaturated, 19
Atelectasis
flow, 12, IS
hematocrit, 14
hemoglobin, 11-12,14-15,155
plasma, 11-12,15
threats/treatment, 261
viscosity, 14
volume, 13-15
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Index 1-5
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1-6 Index
management of,613-615
pediatric,639t,639-640
c
ischemic, 109
Carbon dioxide
conduction, 170-172,171
defined,670, 670-671
rhythms, 176- 177, 177
Cardiac aLThythmias
left atrial pressure, 241-243
anatomy of,44-48,45,46,47,48
septal defects/ICU and,245
fetal, 636
ventricular
neonatal,636
diastole/systole,66
Cardiac disorders
left assist devices/lCU,245
ischemic,109
left pressure/ICU, 241-243, 245
myocardial infarction
right pressure/1CU,241-243
management of,490-491
Cardiac surgery
pathophysiology of,91-93,490
ICUs and, 245
myocardial ischemia,245
open heart, 595,596
treatment,261
acute phase care in,710-7 I 1,714
pathophysiology of
assessments in,708
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Index 1-7
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1-8 Index
Case studies
Chest tubes, in ICUs, 235, 235-236
Catheters,in (CUs
Chloroflurocarbon propellants, for metered-dose inhalers, 786
two-lumen, 241-242
Cholinergic blocking drugs,pharmacology of, 782
Cerebral palsy
pathophysiology of,476--47 7
cardiopulmonary physiology of
Chronic primary dysfunction
central, 54
angina,525-526
peripheral, 54-55
asthma,519-520
682-689,684-689,686t
chronic bronchitis, 514-516
esophageal, 139
diabetes mellitus, 533-535
pericardial,139
emphysema, 516-518
pleuritic,138
hypertension, 531-533
Chest therapy
obstructive patterns in, 514-522
pre/postoperative, 659-660
restrictive patterns in, 522-523
compression
valvular disease, 528-529
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Index 1-9
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1-10 Index
Crackles,defined, 219-220
Diaphragm
Craniosacral therapies, secondary dysfunction and, 437
anatomy of. 26,26-28, 27, 28
CT; sec Computerized tomography (CT) Dipyridamole, for pharmacologic stress testing. 199
pediatric
plans and. 126
D
Down syndrome
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Index 1-11
anticholineSterascs.781 E
antihistamines, 785-786
Echocardiography
bronchodilators. 778, 779
defined, 20 I t, 203-205
Edem a
cort icos tcroi C\s . 785
mucolytics, 786
xanthines. 785
pulmonary . 717-718
findings, 459
goals, 459
(DTPA) aerosol
methods in, 459-461, 460t, 461
Dys func tion; see speci fic typcs, e.g . . Primary dysfun ction.
arrhythmias and. 177, 178, 179-184, 179-184
Secondary dysfunction
conduction and, 170-172, 171
Dyspnea
evaluation of, 174. 174-177, 175, 176, 177
acute, UO
platypnea. 135
trcpoplH:a. 135
Emotional stress
fight/f1ighUfright and, 20
Emphyse ma
i nte n si vc care or. 236, 236t. 239
chronic primary
pathophysiology oc. 91-92
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1-12 Index
Endocrine disorders
oxygen transport and. 8. 10- 12, 13. 19
Environment
pulmonary aging changes and, 675-677,677. 677t
Epinephrine
breathing, 420,420-421
cardiac, 708-709
training guidelines. 43 1-432,432
pulmonary, 708-709, 7 15
training and prescription for, 722-723
F
airway clearance teChniques and. 329-330. 359-36 1. 361 t
defined. 265-266
cardiopulmonary, 725. 725-726
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Index 1-13
cardiac, 716--718
Fright/flight/fight reactions; see Fight or flight syslCms
G
Family history, patients and, 142
Fibrosis
Gaseous vapors, environmental effects of, 16
H
ICUs and, 230-231, 234t, 234-235
Forced expiratory techniques (FET), active cycle breathing and, Heart block, treatment for, 777
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1-14 Index
ischemic. 109
left ejection fraction,200
myocardial infarction
left output, 636
management of,490-49 j
Heart sounds,patient assessments and, 221-222
myocardial ischemia,245
ICUs and,245
treatment,261
acute phase care in. 7 J07 ll, 714
pathophysiology of
assessments in, 708
arrhythmias. 91-92
availability, 704
Heart failure
trends in, 70G
acute,pathophysiology of,93
waiting list criteria, 70S,70S
congestive
when to use,704
pathophysiology of, 93
facility vs. home based rehabilitation in,716-718
primary/lCU, 594,594,596
history of, 704
Heart function
other transplants and,709-710
afterload in,13
outpatient care in, 713-714, 714
conduction,170-172, 171
assessments,707 -70S
blocks,184-186,185, 186
defined,70S-709, 710,710--713
preload,13
Hematology,oxygen transport and,S
ventricular
Hemiplegia,chronic secondary dysfunction and
diastole physiology,66
management of,541-543
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Index 1-15
HFCC; sec High frequency chest compression (HFCC) Hypothyroidism, cardiopulmonary effects of, 109-110, 110
History
Home-based care
side effects of, 7J 8
management of,722
Incentive spirometry (IS), defined, 754, 755
Hypercapnia
percussion/vibration,652---653, 657
ICUs and,239
pOsitional rotation, 649, 649, 650-651
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1-16 Index
Infection
discharge, 574
ICUs and,574
environment, 576. 576y
oxygen transport threats and,255
function optimization,570,571
Inhalers monitoring,572,572
metered-dose. 777,778
patient information,571-572,572
bronchodilators,723-724
personal recognition,574--575
defined,755-756,756
pharmacological agents,572-573
powder,pharmacology of,786
upright to supine position,570
Injuries
primary dysfunction and,579-596
448-450.450
fractures, 604--606
lnspired air head injuries, 606-609, 607,608
dysfunction/lCU,587
obesity, 602--603
hypercapnia. 239
management of, 486-487, 523
hypocapnia, 238-239
radiography of, 162,163
hypoxemia,237t, 237-238
respiratory failure and,579, 580t. 581
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Index 1-17
IPPB; see Inte.rmiltent positive pressure breathing (JPPB) Larynx, anatomy of, 35, 35-36
IPV; see Intrapulmonary percussive ventilators (IPV) Late sequelae of poliomyelitis, chronic secondary dysfunction and
Isoproterenol (Isuprel), pharmacology of,777,784 Left ventricular assist devices, ICUs and, 245
JVO; see Jugular venous distension (1VO) Listening skills, secondary dysfunction and,428,429, 430 428
K
Liver function, laboratory tests in, 194, 194t
Kidney disorders Long sitting self assist techniques. 379, 379-380, 380
Kyphoscoliosis
Lung anatomy,40-44, 41, 42t, 43
L
oxygen transport threats and, 253
adrenal,193t,194
Lung function
immunological, 194t,194-195
Lung injury, management of, 625. 626
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1-18 Index
availability, 704
MAS; see Meconium aspiration syndrome (MAS)
ethical, 704--705
Maximal voluntary ventilation, pulmonary function tests and, 149,
organ donation,704
149-150
patient education,706
Mean oxygen pressure, defined,12
psychosocial implications,705-706
Mean oxygen tension, defined, 12
rejection,704
Measurements, I 17-123
trends, 706
characteristics of, I 18-122
surgery and,706
Mechanical body positioning, 316
physiology, 707
Meconium aspiration syndrome (MAS), management of, 641-642
anatomy of, 50
chronic airflow I imitation,5 I 4
in oxygen transport,16-17
chronic bronchitis,514--5 I 6
M
emphysema, 516-518
Malignancies
myocardial infarction, 526-528
Marfan syndrome
ankylosing spondylitis, 557-558
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Index 1-19
hemiplegia, 541-54
pharmacology of, 777, 786
scleroderma, 556-557
M ic rocircu lation
alvcolitis, 477-478
assessment of, 295-296
angina, 488-490
bed rest and, 291, 291-295
asthma, 481-483
cellular response to, 269-270
bronchiolitis, 477
long term responses of, 278-280, 279
emphysema, 478-481
obstructive lun g disease and, primary dysfunction/ICU,
hypertension, 488
584-585
tuberculosis, 487-488
prescription for, 266-- 267, 270--276, 273, 274t, 278t
Medical su rgical con d itions, primary dysfunction secondary to, preventive effects of, 291-292, 295
495-508
secon dary dysfunction and, 436
mObilitylrecumbency,500
283t, 284, 285, 286,290, 290-291
pathophysiology, 500
Monitoring
perio[Xrative course, 496, 496--500, 498
of body positioning, 317-3 I 8
Metabolic disorders
pulmonary, 708-709, 715
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1-20 Index
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Index 1-21
chest percussion/vibration,652-653,657
program goals for, 700-701
development in
chronic,538-543
ca rd iac, 636-637
ICU,600-602
patent ductus arteriosus in, 639--640 Nitrogen, ambient air co ntent of, 15-16
associated cardiology of, 639t Noncardiogenic pulmonary edema, management of,625, 625
systemic, 103-107,104
in vasi ve, 205-207
and, 661-663,662
noninvasive, 199-205
systemic,103-107, 104
with pharmacologic stress, 199
musculoskeletal,679-70 I
planar, 198-199
693,694,695
magnetic resonance imaging, 207
diagnosis in,680
ventilation-perfusion lung scan,206
function,689
monitoring in
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1-22 Index
oxygen, 726-727
debt,13
Nutrition
demand,4, 13
o
myocardial function, 17-18
secondary dysfunction/ICU,602-603
airways, 16
pathophysiology of,602
diffusion,S, 12,17
pathophysiology of,71-72
measures/indices. 5
primary/le U perfusion, 17
bagging,587
peripheral circulation, 18
breathing,588
basics of, 749,750, 750t, 751,752
coughing, 588
high-flow systems in, 750, 751-752
mobilization, 584-585
low-flow systems in,750. 750. 750t,751
nutrition,583
obstructive lung disease and. primary dysfullctionlICU, 5g6
oxygen, 586
Oxygen transport
secretion ckarance,587-588
threats,253
Occupational history,patient,141
mobilization and,270
Orthostatic hypotension,defined,783
treatment,256-263,257, 258-259, 260,261. 262
Osteoporosis, chronic secondary dysfunction and management of, Oxyhemoglobin,cardiopulmonary physiology and. 67-68,68
553-555
Oxyhemoglobin dissociation, cellular respiration and, 15
p
Outdoor environments, oxygen transport and, 16
cascade, 12, 12
oxygen transport threats <Lilli, 255
consumption,4,6, II, 13
respiratory failure and,579, 5801, 581
supply-dependent, 13, 14
chest wall, 224, 224
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Index 1-23
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1-24 Index
infection, 574
Perfusion
monitoring,572, 572
cardiopulmonary physiology of, 61-65,62,63,64
pharmacological agents,572-573
in oxygen transport, 17
treatment in,569-571,570,572-574
Peri phera I chemoreceptors
transplant,703-718
cardiopulmonary physiolugy of,54-55
pre/postoperative,659-660
Pharynx,anatomy of, 33,34-35
airway suctioning,653,657
Phentolamine (Regitine)
positional rotation,649,649,650--651
pharmacology of,778
postural drainage,652,653r,654 56
Phenylephrine (lsophrin,Neo-Synephrine), pharmacology of,
common diagnoses in, 638t,638 48
777-778
cardiac,639t, 639 40
Pheochromocytoma, phentolamine and,778
pulmonary,64 48
Phonation, musculoskeletal/neuromuscular disorders and,699-700
myelomeningocele in,646,646
mechanical, 316
pneumonia in,642
physiological effects of,301-313, 302
Percussion
exercise/mobility,265-296
in airway clearance,323-324
acute responses to, 270--271,271,272,273,274, 274t
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Index 1-25
bed rest and, 291, 291-295 Pneumotaxic centers, cardiopul monary physiology of. 54
cellular responses to 269 -270
. Pneumothorax
de fined 265-266
, different ial diagnosis of, 227t
long term responses of, 278-280,279 radiography of. 164. 165
monitoring and. 275, 285-286,288, 289,290, 291-292 secondary dysfunctiun/ICU and. 605
multi syst em effects of. 278-280,279 Point of maximum impulse (PM!), defined, 220
oxyge.n transport/metabolic d em and and, 267-268,268,270 Poisons, respiratory failure and, 579, 580t,581
pathophysiological c on d iti ons. 270--271,271 Poland's syndrome, pediatric management of, 648
prescription for. 266-267. 268. 270--276. 273, 274t,276,278t Polio, respiratory failure and,579,580t,581
preventivc crfc(,ts or. 291 292 . 295
- Poliomyelitis
stimulus in, 277-27R. 278 chronic secondary dysfunction and
impact of sy temic diseases on, 99-100 management of, 550--552
oxygen ll'llnsport and, 3-20 pathophysiology of, 550
pediatric, 648--663 with s econdary kyphoscoliosis, exercise training for 437-440,
Plasma, in oxygen transport, 11-12,15 long sitting self, 379, 379-380, 3S0
pediatric, 642
butterfly techniques and, 408,409, 410
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1-26 Index
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Index 1-27
Copyrighted Material
1-28 Index
therapy in Red blood count (RBC), laboratory tests of, 190-192, 191t
assessments. 707-708
Ret1exes, cardiopulmonary physiology of, 55, 55-56
physiology, 707
pulmonary signs of, 715
Pursed-lip breathing
cardiopulmonary effects of, 108, 108
R
Reserpine, pharmacology of. 779
RA; see Rheumatoid arthritis (RA) Respiratory centers, cardiopulmonary physiology of, 54-55
Radiography
Respiratory distress syndrome (RDS); see also Adult respiratory
edema, 165,166
gastrointestinal dysfunction and, 620
motion, 159-160
thromboembolism. 620
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Index 1-29
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1·30 Index
201 t, 202-203
Supraventricular arrhythmias, In electrocardiograms, 177,
I
Sinoatrial node (SA)
179,179,180,181
Sleep apnea
intrinsic factors, 500
Smoking
preoperative management, 502
oxygen transport 16
;,urgical effects, 500
pathophysiology of,
Systemic circulation, anatomy of, 48-49
Starling effect
liver, 107-108, 108
Stress
management of, 555-556
emotional, 3
pathophysiology of, 555
exercise, 199
Systole, ventricular. cardiopulmonary physiology of, 66
pharmacologic, 199
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Index 1-31
T Thorax
anatomy of, 23-25, 24. 25
T3; sec Triiodothyronine (T3)
mobilization of, 399-401,400
T4; ec Thyroxine (T4)
secondary dysfullcl"ion and. 436
Tachycardia, trc.<ltmem of, 777-778, 779
Thromboembolism
Tachyuysrhythmias. intensive care of, 239, 240t-241t
cardiopulmonary effects of, 108
Tachypnea. patient assessments and, 216
respiratory failure and, 620
Tactile fremitlls. patient assessments and, 225, 225,226
Thrombosis, deep vein, management of, 623--624
Tc-99M-macroaggregated albumin; see Technetium-99M-
Thyroid function, laboratory tests of,193t,194
Illacroaggregatcc\ albumin
Thyroid stimulating hormone (TSH), laboratory tests of. 194
Tc-99M-Pyp; scc Technctiulll-99M-pyrophosphate (TcPyp)
Thyroxine (T4), laboratory tests of, 194
Tc-99M-sl)stamibi; sec Ted1l1etium-99M-sestamibi
TI A; see Transient ischemic attack (TI A)
Tc-99M-teboroximc, Technctium-99M-tcboroxime
Tidal volume (TV),systemic disease effects on, 106
Tc-99mDTPA; see Technetium-99M-diethylene triamine penta-
Timing
acetic (DTPA) aerosol
asymmetrical dysfunction and, 406
Teams
ventilation facilitation and, 399
home-based care communication in, 728-729
Tissue assessments, in oxygen transport treatment, 262
in ICUs, 574, 575
Tissue extraction, oxygen transport and, 18-19
Tec hnct ium-99M-die t hy l ene triamine pe nta-ac etic (DTPA)
Tissue perfusion
aerosol,for ventilation-perfusion scans,20 It, 206
in oxygen transport,S
Technetium-99M-mncroaggregated albumin, for ventilation-
oxygen transpOIt threat.s
perfusion scans, 20 It, 206
TLC; see Total lung capacity (TLC)
Technetiull1-99M-pyrophosphate (TcPyp),defined, 20 I t,203
TLSO; see Total contact thoracic lumbar sacral orthosis (TLSOs)
Technetium-99M-sestamibi, defined,20 I t, 202
TOF; see Tetralogy of fallot (TOF)
Technetium-99M-teboroxime, defined,20 I t, 202
Total contact thoracic lumbar sacral orthosis (TLSOs), defined,
TEE; see Transesophagcal echocardiography (TEE)
384-385
Tenderness. patient assessments and, 223
Total lung capacity (TLC)
Tcrazosin (Hytrin), pharmacology of,778
sickle cell anemia and, 109
Terbutaline (Brethine, Bricanyl), pharmacology of,778
systemic disease effects on, 106
Testing
Toxic-inhaled materials,oxygen transport and, 16
arterial blood gases and, 153-157
Tracheas
documentation and, 123-126
anatomy of, 36-40, 37, 39t
electrocardiograms, 169-187
deviation assessments and,225, 226
exercise
TracheomaJacia, respiratory failure and,579, 580t, 581
pre scriptions and,274, 274, 276-277, 280--285, 281, 282t,
Tracheostomy tubes, artificial airways, 764-766, 765,767-771,
283t, 284-286,290, 290--291
768,771-774,773t
training and, secondary dysfunction, 426-432
cuff inhalation, 765-766
ICU unit monitoring systems,229-246
metal,764
measurements and, 117-123
plastic, 764-765, 765
multisystem laboratory assessments and, 189-195
Training,exercise and, 274,274, 276-277, 280--285, 281,282t,
nuclear imaging/radiopharmaceuticals, 197-207
283t,284, 285, 286. 290, 290-291
patient assessments and, 209-228
Tranquilizers, for I CUs, 572-573
pulmonary function, 145-15 I
Transesophageal echocardiography (TEE), defined, 197, 20 It,
routine radiographs, 16(}-161
204, 205
x-ray interpretation, 159-167
Transient ischemic attack (TI A), transesophogeal
Tetanus, respiratory failure and, 579, 580t, 581
echocardiography (TEE) for, 205
Tetralogy of fallot (TOF), pediatric management of,640
Transient l<lchypnea of the new horn (TINB), pediatric
ThAIRapy (TM), clinical applications and, 358, 358-359
management of, 641
Thallium 20 I, for cardiovascular testing, 200-202, 20 It
Transplant patients, 703-718
The Flutter (TM), for airway clearance, 328
cardiac, 708
Theophylline,phannacology of, 785
acute phase care, 710--711,714
Thempist requirements
assessment, 708
in I CUs, 568, 569
equipment/monitoring, 708-709
for transplant patients, 706
exercise guidelines, 712
Therapy, physical; see Physical therapy
facility vs. home based rehabilitation, 716-718
Thoracic disorders, primary dysfunction secondary to, 500--502
goals, 7 J 2
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1-32 Index
interventions, 710-711,714
Tumors,respiratory failure and,579, 580t, 581
medication, 716-718
Turner's syndrome, associated cardiology of,639t
post-transplant,708
Two-lumen catheters, in ICUs, 241-242
pre-transplant, 708
u
rejection signs, 714, 715,716
considerations for
Upper airways, anatomy of,32-36,33, 34, 35
availability,704
Upper/lower extremity exercise,testing/training and,primary
ethical, 704-705
dysfunction,419-420
organ donation,704
Upright body positioning,302-308,303,304,305,306, 307,308
rejection,704
Urinary retention, treatment of,780-781
trends, 706
waiting time,705
Valves
when to,704
flutter,259-260,260
post-t.ransplant in,708,712-713,713t
Vascular systems
pre-transplant in,708-709, 710
aging changes in,673,673-675, 674t
surgery and,706
Vasodilators, treatment with, 777, 778
assessments, 707-708
Ventilation facilitation,3 3-415
physiology, 707
chest/shoulders and, 392
therapist requirements,706
diaphragm inhibition and,402-405, 404, 405
Trapezius
diaphragmatic breathing and,389,390,391, 392,394,394,
Trisomy 13, associated cardiology of, 639t intrapulmonary percussive, 363, 364
Trisomy 18, associated cardiology of,639t lateral costal breathing and, 396, 397, 399,399
TINB; see Transient tachypnea of the new born (TINB) musculoskeletal/neuromuscular disorders and, 680
Tuberculosis
normal timing and, 399
management of,488
oxygen rransport and,5,16
pathophysiology of,487-488
to perfusion ratio, 17
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Glossary G-33
rolling,388
Voice breath sounds,patient assessments and, 220
sitting, 388
Volume-assured pressure support (YAPS), defined, 758
sniffing, 392
Volume/pressure, cardiopulmonary physiology and 57-58, 58,
, 66
standing, 389
w
strategies for, 387-389
verbal, 414-415
Waiting lists,for transplant patients, 705, 705
dysfunction/ICU, 588,5RH-589,589
WBC; see White blood count (WBC)
Ventricular function
Weights, for oxygen transport treatment, 259-260, 260
al'tcrload in, 13
Wheezing
cardiopulmonary physiology of, 65, 65--67, 66,67t
defined,219-220
use of,169-170
alveolar disease, 162, 162
left
atelectasis, 164-165, 165,166
assist devices/ICU,245
basic structures/shapes, 160
ejection fraction,200
bronchi, 162, 162
output,636
bronchograms in,162, 162
pressurenCU, 241-243,245
congestive heart failure,164, 165,166,167
preload, 13
fixed position, 159-160
right
interstitial pulmonary disease, 162, 163
prcssurenCU,241-243
lateral chest, 159-160
Vibration th.:rapy
pneumothorax, 164,165
pathophysiology of,473-474
uremia, 165,166
Viscosity,of blood, 14
Xanthines, pharmacology of,785
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