UNWANTED DRUG INTERACTION

BAB I
PENDAHULUAN

Interaksi pada tingkat metabolisme obat merupakan bentuk dasar dari

banyak interaksi obat. DRUG-DRUG INTERACTIONS Interactions at the level
of drug metabolism form the basis of many drug interactions. Most commonly, an
interaction occurs when two drugs (e.g., a statin and a macrolide antibiotic or
antifungal) are metabolized by the same enzyme and affect each other’s
metabolism. Thus, it is important to determine the identity of the CYP that
metabolizes a particular drug and to avoid coadministering drugs that are
metabolized by the same CYP. Some drugs can also inhibit CYPs independently
of being substrates. For example, the common antifungal agent, ketoconazole
(NIZORAL) is a potent inhibitor of CYP3A4 and other CYPs. Coadministration
of ketoconazole with the anti-HIV viral protease inhibitors reduces the clearance
of the protease inhibitor and increases its plasma concentration and the risk of
toxicity. For most drugs, the package insert lists the CYPthat carries out its
metabolism and notes the potential for drug interactions. Some drugs are CYP
inducers that can induce not only their own metabolism but also the metabolism
of coadministered

BAB II
PEMBAHASAN

A. Interaksi Farmakodinamik
B. Interaksi Farmakokinetik pada Tingkat Absorpsi dan Ekskresi
C. Interaksi Farmakokinetik pada Tingkat Metabolisme, terutama pada enzim
sitokrom P450

BAB III
KESIMPULAN
 BAB IV
DAFTAR PUSTAKA