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Viral Hepatitis

Hepatitis A Hepatitis B Hepatitis C Hepatitis D Hepatitis E


Non-A, non-B
Previous names Infectious hepatitis Serum hepatitis Delta Agent
hepatitis
Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus
Cause
(HAV) (HBV) (HCV) (HDV) (HEV)
Fecal–oral route, poor Parenteral, Sexual and oral– Parenteral, Sexual and oral– Parenteral, Sexual and oral– Fecal–oral route, poor
sanitation, Person-to-person oral contact, Perinatal oral contact, Perinatal oral contact, Perinatal sanitation, Person-to-person
Mode of transmission contact, Waterborne, transmission transmission transmission contact, Waterborne,
foodborne, Oral–anal sex *occupational hazard for foodborne, Oral–anal sex
health care personnel.
Incubation Period 2-6 weeks 4-24 weeks 2- 22 weeks 4-21 weeks 2-9 weeks
7-10 days before illness Degraded by enzymes, if Not identified in feces Not applicable Probably present in feces
Virus in Feces 2-3 weeks after symptoms present
appear
∙ Anicteric and ∙ Arthralgias and rashes ∙ Same with HBV usually ∙ Simultaneous infection ∙ Similar to hepatitis A,
symptomless ∙ Fever, respiratory mild with HBV and HDV can often milder course
∙ Symptoms Appear: Mild, symptoms(rare) lead to a mild-to-severe
flulike symptoms with ∙ Loss of appetite, or even fulminant
low-grade fever dyspepsia hepatitis
∙ Anorexia ∙ abdominal pain (RUQ)
∙ Jaundice and dark urine ∙ general aching, malaise,
∙ Indigestion mrked by and weakness
vaague epigastric ∙ Jaundice
Signs and Symptoms
distress, nausea, ∙ light-colored stools and
heartburn, flatulence dark urine.
∙ Aversion to cigarette ∙ Liver may be tender and
smoke and strong odor enlarged; spleen is
jaundice enlarged and palpable in
∙ ↑ AST/ALT a few patients.
∙ Children < 6 years often ∙ Posterior cervical lymph
have no symptoms nodes may also be
enlarged.
Carrier state No Yes Yes Yes Unknown
None specifically for Hepatitis
Vaccine Available Available None D. Hepatitis B vaccine should None
be given
Safe sex; screening of blood
products; use of sterile Use of sterile instruments
Food and water hygiene
Prevention instruments and needles and needles, safe sex Prevention of HBV infection Food and water hygiene
Immunization
HBV vaccination, post-
exposure prophylaxis
Fulminant hepatitis, Chronic Fulminant hepatitis Fulminant hepatitis
No chronic hepatitis is Chronic disease (possibly
Complication disease (possibly Hirrhosis, High risk of severe chronic High mortality rate in
associated cirrhosis, HCC)
Hepatocellular Carcinoma) liver disease pregnant women

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