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dS POND IO TRY — — 3en prema Probrway, wisp 24049 sok TRTTY @ DBystopidemia, « (en FOS fiticdCa ms) Atp -4 @Poyslipidamia » ic O dosvider of tpoprotete muda bolinne dnchadéns LP rerpr- Cduction or deficiency nale UO np (de Det TAG > BWOng [ot HEL Dpmate < SOs [at YLDL ry leOmglde — ~ dota choleederol > 2omed dt Trditolow: cantee primary or Secondang DB Prima prevention for ~ LDL-< 2140 mglel = BM bage do-75 9 WH ULC bin 70-184 mgidt -Mo BM & estimated JOyar A@scvorik of 2757 Lae bin Yo- Avy LDL-¢ bbe 710-84 mp [de u for’ jotis PSecondany pruuention fo v = Pla tie Enna CHO (earenang healt Senet) ie Ma, angina, prior cormary Ne = Ohér cv dicease Cie cfrcke, transient dichente attock 4 Par) Combination of hick factor dat sasult im Wear nat of ASEND risk >20% CED DS EGER £48 nd frst J T5™ a snisk egpicalint for cardinvacuitan events im bmn pe the Ff pts GDM dhougd fo have sindlar 2iab@ bn Ole dixcose ps Man >be 2 type 2 bany flue CHO NESE spostor, 08 Men > SU: 3h or topd Offer Rab actos od SOR cece, wihagen Brvcdsting Opec rise jabrs or si >5SyS - Men De of cing aft tous have bad D™ Cyped 2) v for > 2O0yrs Y Hog rove anotur RF for CHD, or < for % Sys w [rood another CHD Aish factor aplsferinle metepicalionsor 242 prundtens wd lost For ocecvelght Lobesepa © dks, AEmbic CCH & snaking See @Indensvhies of spotin tnecapg Ca\iase doin doses ae BO otanle abie |r Las Galery Stebin vine bbiicrenat] v lout LPL C ona: (on, %- SOF < 20% LeL-€ 69% 750 gs sactette 10-20 abgse 25-AD -Ato ¥en 010 ™3\. ovat wccckodin 0 . YS LE rovachakin BO me, pL owasicie 203, - aglatin JO-4O"S, + lovadiotin AO Pcsevi % | lo : Fong Somos ove, -prravadie 18, - prancatai~ 10-204, ayrupary 7 - pad - - an - mrogsing 2 RACIAL 10 puo2 fords rap ap Or (Cypanbrefs 11099 mam) ss x x 87 Mossy naperrioo, > Phacmacplogial Reqor Lo ppauentinn a a 2 the 40 mar ASC Adee Should be assered ae Sn ORR eerneies (HY a0) AW & ¢ Lbdwlls B2says & LOL-< > ongidl ---- high inknerty stabi th BLY sll ondiended Addons aon: Statin dius cam be constdored. Goal t= 4the LL-c level iy 60% © Adoits IM AO Ses + ined Prewn OVO> 4+ LDLe bf 70-184 mg] dl 0 Atay howe Tam» trond & cleat madercke stotin fiorapr hag tnensihy Stedlintherapy ---- fryer ove rak 27S °G tio how ap pri: HH LOrpar CVE rk 6 > 1Seosnnedentts 40 hale indestty atins ~Tf Ongar vb ak Lbin SH 3S% 3 mo dorate Wekathy stabi dhouayg SPhramocoleee Ra apr IP prewentvo- ~ TpBae & © S 1S Mao saxty concera ~ -- high Walentity statin © PAS or Somle] concom - ~~ moderate intensihy Stetins Ala usual risteps & stable cvD: ~F pl dowrachiere at wot 50% redo in US Cor Bale acd seguectrants > are efperton agtanst mild -4o necdarade elwatin q Lue e a ate 4 [deny decloase LEC by 40-16 4. = colestape! 105 [doy [ Wu AS, ) er [eiepuog 12 7 AO) 9 by vopURPAD saps nS OdaaprND CYR, ~ ow pundn sjrm-9y7 - Carmnaiaqua sy bey ow $o vord|yeva b vonlndinn dog_ Compu eM] $97 wn Gy (unas ok PD Sm ) sss. (rerep ogi ¢ pobunfs “roa ‘poriaa uo) rend ~ vCholestyranine Hg ldag —¢ a ¥ colestopel ang | hata more pronounced estpeof Colesovelam Ine base, | P ie - Que aNso eeffecfome rihon Used in conmbinghén eit selic or ALAC pls marked iy 2leveded plaon i leu of LaL-c E Slatin. 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Ldentopced 1A the absencect over bleeding when pis present Uh Ses Of ble Loss or anemia auch 00 Lignt keadedness, Syncope, angina or Opspnea, or —rohen Auactine déapnestic evaluclion reeea! IDA Cérort de Quemix) or - & pesttow zeoal pacerlt bid toot UGE + whan tee orwee of bleeding ( Located aboee Lganunt Htriegge - i ta commenect 6% enargenes P haroly div com exsanpuniation ,Aattur che duet decompearonn Other underlying Alrener ~ Chareect nellaading 4 dealin deparas onthe qf Jattors: oe OB O38 ad hagher Ais ) - pb @ Otter comorbidaties : oe C+ Pe alteady haveing depresses hancdya mt stebuo ly iaciqeardin, HoT) om ose opnagéica (1-18) - peptic uleers C31- 644) ase AT ei rere icral waiees( 680). 9 1 tan a) pele = Yoo ular ecfosiaa ( 0-6% ~ Mallory wens tear ¢ 3-5 lo) 5 = Hemorrhagic / esau garimpediug duefo ASAIDsoF leo lat 6 O- WBfo rb some & Ldenctafied ine aod SHE. oF Cased NS Hemorrhagic or erosive gooopetig & ema Qrophogite uu-caue, mild bleding, $ ax rarthy life qnasafening SBME - burrning pyar pre sxacertated by Faring inyprwes® | meals a Se lormplex ash PUD. vrwrxadly ¢ QD to 90 pr om muy d Gunnk ny pepo - perianal onngorar y= ge gyms ) ape me PGartrdundenal muceca) deqense: (3 leoxkd) “Mucus ticarbonate Prapwolzpid Layer’ act co ph ~Sugace eprfiotal cells $) ali mochanisne: " » mucus prodeu “ epetiaatiad cell Conic transporters thed maintatre trdrecellulor pH v2, 8 biearborade production, & Ertraceliaion qaighl functio (7 Tu mocrovaaculan syste tute jue gactric nuk tochemicel barrier ; Heog oa) layer, prveiae® fferenate heat shock proteins qnat provent protein doneturatisx L probed coll From Factors bate Incneaued 1%, cyjoreric agets vr OXidectice stress ~Provagiondins’ PGs) ere Wprrtand H Zasiante eptiteliad f tH Saatnt a rence pspair, Stree Me mucosa conamns abundard nscopors for Ps Seca § = Aelense Cf mucesed bicarbonate (HCOS) & mucus: e ~ inbitct povictel call acid secretion = mainiain mucesal tld Fivid & epttrelo) Awinshtotion - AB Gomcic exert oy PGs is modulated by COXL N00 is important th the moterenane of ganinic mucos al integrity: @Gawric secretion + Hele pepsineger are Au tao prinetpe gash Products capable ey inducing, mucosal Injury fla an innportant Able tn 3 9 f-protein degention 4 - absorption of, tron, GB, mp, & Vit Baz - belting ingeoted kackenta Stimulation :{ - Cholincryic weput wa he vague Aere Cota , Le Hestaminergic enput from weal gavirce Apurces. ¥ 2st use! of, acid oxcrclier vqcan tuning tre night ims blovsest Tevet decriigs Aue moraing: POD (Gost &dvodenal vicers) : Llers: breaks Guthe mucesal curate Sum i slap, the dep “eatendang, do dit. Submucesa. =H pulord &ASAIDS ace dus amok Common isk Aadiors - 23 doctor vésit (year Otter Ris: - COPD pe er al insuxyicienty) > Comnar heort diseane : = dlcolanl” nse (esp: Former cuwant 0 former _ Adricau-dmeriean Adee dobaceo Use oa - Older ge

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