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Mild hypothermia increases View more articles »
blood loss and transfusion
requirements during total hip Citing articles (552)
arthroplasty
H Schmied, MD a, A Reiter, MD a, A Kurz, MD b,
D.I Sessler, MD , b, S Kozek, MD c
a Department of Anaesthesia and Intensive Care
Medicine, Hospital of Amstetten, Austria
b Thermoregulation Research Laboratory, Department
of Anesthesia, University of California, San
Francisco, United States
c Department of Anaesthesia and Intensive Care
Medicine, University of Vienna, Austria
Available online 20 December 2003
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doi:10.1016/S0140 Get rights and
6736(96)904663 content
Abstract
http://www.sciencedirect.com/science/article/pii/S0140673696904663 1/3
9/22/2016 Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty
Summary
Background Invitro studies indicate that
platelet function and the coagulation
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cascade are impaired by hypothermia.
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However, the extent to which perioperative
This document hypothermia influences bleeding during
does not have surgery remains unknown. Accordingly, we
an outline.
tested the hypothesis that mild
hypothermia increases blood loss and
allogeneic transfusion requirements during
hip arthroplasty.
Methods Blood loss and transfusion
requirements were evaluated in 60 patients
undergoing primary, unilateral total hip
arthroplasties who were randomly
assigned to normothermia (final
intraoperative core temperature 36·6
[0·4]°C) or mild hypothermia (35·0 [0·5]°C).
Crystalloid, colloid, scavenged red cells,
and allogeneic blood were administered by
strict protocol.
Findings Intra and postoperative blood
loss was significantly greater in the
hypothermic patients: 2·2 (0·5) L vs 1·7
(0·3) L, p<0·001). Eight units of allogeneic
packed red cells were required in seven of
the 30 hypothermic patients, whereas only
one normothermic patient required a unit of
allogeneic blood (p<0·05 for administered
volume). A typical decrease in core
temperature in patients undergoing hip
arthroplasty will thus augment blood loss
by approximately 500 mL.
Interpretation The maintenance of
intraoperative normothermia reduces blood
loss and allogeneic blood requirements in
patients undergoing total hip arthroplasty.
Correspondence to: Dr Daniel I Sessler,
Department of Anesthesia, 374 Parnassus Ave,
3rd Floor, University of California, San
Francisco, CA 941430648, USA
Copyright © 1996 Published by Elsevier Ltd.
http://www.sciencedirect.com/science/article/pii/S0140673696904663 2/3
9/22/2016 Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty
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