Characteristic of Subjects with High Expression of Galectin-3 Level on Myocardial

Infarction: a Perspective Adverse Cardiac Remodelling

I.N.I Mataram1, W. Aryadana2, A.A.W. Lestari3

1,2
Department of Cardiology and Vascular Medicine, Sanglah General Hospital, Faculty of
Medicine, Udayana University, Bali, Indonesia
3
Department of Clinical Pathology, Sanglah General Hospital, Faculty of Medicine, Udayana
University, Bali, Indonesia

Aims/Background
Galectin-3 (Gal-3), a biomarker associated with fibrosis and inflammation has been implicated in
heart failure (HF). HF frequently develops after myocardial infarction (MI). Several factors has
been found to be related with high circulating Gal-3. This study aimed to know characteristic of
MI subjects with high expression of Gal-3.

Methods
Descriptive, cross-sectional study was conducted. Serum Gal-3 was measured on the admission
time simultaneously with assessing patient’s clinical profile and angiographic parameters.

Results
High level Gal-3 was determined by receiver operating characteristic (ROC) curve and yields
value of 7.67 ng/ml according to study. Subjects with high expression of Gal-3 (> 7.67 ng/ml) in
their serum has mean age 57 ± 2 years, dominantly male on 45 (73%) subjects, normal body
mass index (BMI) on 34 (55%) subjects, dominantly without existing chronic HF on 45 (73%)
subjects, without DM on 37 (60%) subjects, without hypertension on 28 (45%) subjects, smoking
on 33 (53%) subjects. Subjects have mean symptom onset 8 ± 1 hours, with further classified as
onset of presentation within 12 hours on 45 (85%) subjects, presenting with acute heart failure or
advanced killip class (III-IV) on 28 (45%) subjects, and assessment with STEMI on 48 (77%)
subjects. Subjects dominantly classified into 3VD on 18 (29%) subjects according coronary
lesion complexity from angiographic view, IRA in LAD on 41 (66%) subjects, infarcted region
dominantly affecting anterior wall on 40 (65%) subjects, MBG pre-procedure 1 on 38 (61%)
subjects, and TIMI flow pre-procedure 0 on 21 (34%) subjects.

Conclusion
High Gal-3 level in serum was dominantly found on male, normal BMI, and smoking habit.
Subjects present within 12 hours of onset, affected anterior infarction region, CAD/3VD, IRA on
LAD, low MBG, and low TIMI flow pre-procedure.

Keywords: galectin-3, myocardial Infarction, adverse cardiac remodelling, anterior infarction,

MBG, TIMI flow