AUTACOIDS

- aka LOCAL HORMONES

- endogenous substances with biological activity
- not released or stored in glands, not circulated in blood
- are formed at the site of action
- will not go into systemic circulation

CLASSIFICATION

1. Biologically Active Amines

- Histamine
- Serotonin
2. Lipid Derived Autacoids (eicosanoids)
- Prostaglandins
- Leukotrienes
- Thromboxanes
- Prostacyclin
3. Ergot Alkaloids
4. Vasoactive Polypeptides
- Kinins
- Angiotensin
- Endothelin
- Natriuretic peptide
- Vasopressin
- Substance P
5. Endothelium derived autacoids
- Nitric Oxide