Myocardial fatty acid metabolism

Fatty acid: albumin VLDL-TAG LPL Chylomicron-TAG

Fatty acid

bran
e FATP
mem CD36 Acetyl CoA AMPK
Cell Fatty acid
beta-oxidation
Fatty acid MLYCD ACAC
ATP Acyl-CoA
FACS
AMP+PPi
Malonyl CoA Acyl-CoA FAD
Fatty acyl CoA
Acylcarnitine dehydrogenase FADH2
TAG TAG Carnitine
trans-2-Enoyl-CoA
CPT1
TAG TAG H 2O
CT Enoyl-CoA
CPT2 hydratase
Carnitine 3-Hyroxyacyl-CoA repeat Retinoic acid
Acylcarnitine
NAD+
Mitochondrial 3-Hydroxyacyl-CoA Increase in
Matrix Acetyl CoA dehydrogenase NADH+H+ fatty acid
Fatty acyl CoA
beta-Ketoacyl-CoA
FA- H 2O ACOT2
beta-Ketoacyl-CoA CoASH
TCA
CoA cycle thiolase
Fatty acid
UCP FA- Acetyl-CoA
beta-oxidation
UCP Acyl-CoA RXR
(2 C Atoms Shorter)
AR
H+ FADH2 /NADH PP
ADP ATP
H+ H+ H+
ATP5J2 PGC1 alpha

PPAR RXR
IV III II I

H+ H+ H+ Response element PPAR target genes

Cytosol
Nucleus

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