Brekhman Dardymov 1969 Adaptogens PPT Slides Heartwood 2018 PDF

History of Adaptogens
Dr. Israel I. Brekhman
NOVEMBER 1921 - JULY 1994
(His favorite portrait of himself is

this
one depicting
“TheEleuthero
theoreticalroots
basis for separation of a new group of
around his medicinal
neck. substances was laid down by Lazarev, who
The portrait was painted
phrased theinconcept
1991 byof "a state of nonspecifically
F. Tushkin) increased resistance" of the organism (SNIR). The
medicinal substances causing SNIR were named
"adaptogens".
34
•https://www.annualreviews.org/doi/pdf/10.1146/annurev.pa.09.040169.002223
4. Lazarev, N. V., Farmacol. Toxieol., 21, 3, 81-86 (1958)

5. Lazarev, N. V., Ljublina, E. I., Rozin, M. A., Patol. Fiziol. Eks perim. Terapia,3, 4, 16-21
(1959)
34

this
one depicting
“WeEleuthero roots 158 complex prescriptions of folk
have analyzed
around his neck. of Southeastern Asian countries and found that
medicine
The portrait was
116painted in 1991included
prescriptions by plants of tonic action
F. Tushkin)
(in 31 of them, two plants in each and in 40, from three to
seven in each). In all recipes there were incorporated, in
various combinations, 189 medicinal plants, tonic action
having been ascribed to 46.”
35
35

this
one depicting
“PanaxEleuthero
ginsengroots
C. A. Mey., which has been known more
around his neck.
than 4000 years, occupies a particular place among tonic
The portrait was painted
remedies. in 1991 by investigations have shown that
Pharmacological
F. Tushkin)
the basic effect in ginseng action is its capacity to increase
nonspecific resistance of the organism to various untoward
influences.”
36
6. Brekhman, 1. 1., Zhen-shen (Panas ginseng), Medgiz, Leningrad, 182 pp. (1957)
7. Brekhman, 1. 1., Med. Sci. Serv., 4, 17-26, July (1967)
36

this
one depicting“In
Eleuthero
addition roots
to ginseng, the following plants of the
around his neck. family, viz., Eleutherococcus senticosus Max…
Araliaceae
The portrait was
Two painted
plants in 1991
belong byCompositae family … Special
to the
F. Tushkin) mention is to be made of Rhodiola rosea L. of the
Crassulaceae and Shizandra chinensis (Turcz.) Bail. of the
Shizandraceae family.”
37
•Full text:
In addition to ginseng, the following plants of the Araliaceae family, viz., Eleutherococcus senticosus Max., Aralia manshurica Rupr. et Max., Aralia cordata Thunb., Aralia
schmidtii Pojark., Echinopanax elatum Nakai, Acantopanax sessili orum Rupr. et Max., Kalopanax septemlobum (Thunb.) Koidz have been studied (8- 18). Two plants belong to
the Compositae family, viz. Raponticum carthamoides (Wild.) Iljin (19, 20) and Carlina biebersteinnii Be h. (21,22). Special mention is to be made of Rhodiola rosea L. of the
Crassulaceae and Shizandra chinens (Turcz.) Bail. of the Shizandraceae family (2 26).
8. Brekhman, I. I., l v. Si irsk. Ot delenia Akad. Nauk SSSR,9, 113- 22 (1960)

9. Brekhman, I. I., Proc. 2nd Inte . Pharmacol. Meet., 97-102, Prague, 2 23 Aug. 1963, Pergamon Press, Oxford, Czechoslovak Medical Press, Pra e (1965)
10. Brekhman, 1. 1., Majanskiy, G. M., [ v. Akad. Nauk SSSR, Ser. BioI., 5, 762-65 ( 1965)
11. Brekhman, I. I., Eleuterokokk (Eleu therococcus), Izdatelstvo "Nauka", Leningrad, 186 pp. (1968)
12. Brekhman, 1. 1., Kirillov, O. 1., Rast. Resursy, 4, 1, 3-13 (1968)
13. Brekhman, 1. 1., Mate aly k izu cheniju zhen-shenja i drugih lekar st ennih asteniy Dalnego Vostoka, (Materials for e study of Panax ginseng and other medicinal plants of
the Far East), 219-27, Primorskoe knizhnoe izdatelstvo, Vladivostok, (1963)
14. Fruentov, N. K., Materialy k izu ch iju zhen-shenja i limonnika (Materials for the study of Pan ginseng and Shizandra chinen ), 133-40, Izdanie Akad. Nauk
SSSR, Leningrad, (1958)
15. Turova, A. D., Chukicheva, M. N., N olskaja, B. S., Lekarstvennie sredstva rastitelnogo proisho h denija (Medicinal remedies of plant origin), Medgiz, Moscow,
176 pp. (1954)
16. Turova, A. D., Aleshkina, Ja. A., Lekarstvennie sredstva i rasteniy (Medicinal remedies from plants)
Medgiz, Moscow, 314 pp. (1962)
17. Turova, A. D., Lekarstvennie ras tenija SSSR i ih preminenie (Medicinal plants of the USSR and their use), Izdatelstvo "Medi
cina", Moscow, 692 pp. (1967)
18. Zvereva, A. V., Eleuterokokk i drugie adaPtogeni iz dalnevostochnih ras teniy (Eleutherococcus and other adaptogens of Far Eastern plants), Dalnevostochnoe knizhnoe
izdatel stvo, Vladivostok, 257-60, (1966)
19. Saratikov, A. 5., Pichurina, R. A., Izv. Sibirsk. otdelenija Nauk SSSR, Ser. Bioi. Nauk, 4, 113-19 (1965)
Akad. Med.
20. Saratikov, A. 5., Stimulatori central noy nervony sistemi (Stimulators of central nervous system), 3-23, Izdatelstvo Tomskogo Univ., Tomsk (1966)
21. Belenkiy, E. E., Kolla, V. E., Ma terialy k isucheniju shen-shenja ; drug;h lekarstvennih rasteniy Dal nego Vostoka (Materials for the study of Panar ginseng and other
medicinal plants of the Far East), 5, 119-22, Primorskoe knizhnoe izdatelstvo, Vladivostok (1963)
22. Kalla, V. E., /8 . Estestv. Inst. Permsk. Univ., 14, 6, 209-13
(1963)
23. Zotova, M. I., Krilov, G. V., Sara tikov, A. S., Is . Sibirsk. Otde lenija Ak . Nauk SSSR, ser. Bioi. Med. Nauk, 8, 111-19 (1965)
24. Lebedev, A. A., Materialy k izuchen iju shen-shenja i limonnika (Ma terials for the study of Pan= ginseng and Shizandra chinensis), 2, 178-88, Izd. Akad. Nauk SSSR, Moscow-
Leningrad (1955)
25. Volicer, L., Janku, I., Motl, O. Jiricka, Z., Proc. 2nd Intern. Pharmacol. Meet., 29-38, Prague, 20-23 August 1963, Pergamon Press, Oxford, Czechoslovak Medi cal Press, Praha
(1965)
26. Lupandin, A. B., 0 vlijanii limonnika na chustvitelnost organizma k nekotorym neblagoprijatnim vos deis ijam (On in uence of Shisandra chinensis on sensitivity of the
organism to some untoward e ects), dissertacija, Khabarovsky gosudarstvenniy medicinskiy insti tut, Khabarovsk, 230 pp. (1967)
37

this
one depicting“InEleuthero
conformityroots
to the above-mentioned requirements
around hisEleutherococcus
neck. senticosus is placed first, followed by
The portrait
Panaxwas ginseng,
painted in 1991 by carthamoides and Rhodiola
Raponticum
F. Tushkin) rosea.”
38
•Full text:
38

“Panax ginseng, Eleutherococcus senticosus, Raponticum
carthamoides
(His favorite and Rhodiola
portrait of himself is rosea contributed to a more
this sparing use of carbohydrates and to an enhanced
resynthesis of
one depicting Eleuthero roots glycogen and high energy phosphorus
compounds. This action was found to reveal itself
around his neck.
unequivocally
The portrait was painted in 1991 byunder physical strain.
F. Tushkin) Numerous data on the increase of body weight, on
restoration of blood albumin after massive bleeding, on
stimulation of immune body production, testified to a
peculiar anabolic action. Its characteristic trait was the
fact that it manifested itself only in the presence of an
appropriate background and, contrary to steroid ana-
bolic agents, was not accompanied by virilization.”
39
•Full text:
39

“One of the most important indices of the action of
(His favorite portrait ofwas
adaptogens their is
himself capacity to increase efficiency both
this after a single (stimulant action) or prolonged (tonic action)
administration…
one depicting Eleuthero roots They did not lead to disturbances in the
around his neck. normal sleep of man, or in falling asleep.”
The portrait was painted in 1991 by
F. Tushkin)
40
•Full text:
40

“Eleutherococcus senticosum and Panax ginseng were
found
(His favorite to possess
portrait radioprotective
of himself is and medicinal action in
this a single X-ray irradiation of animals.”
one depicting Eleuthero roots
around his neck.
The portrait was painted in 1991 by
F. Tushkin)
41
•Full text:
41

“Eleutherococcus senticosus was tested in experimental
oncological
(His favorite portrait of researches.
himself is Its preparations were found to
this inhibit the urethane-induced lung adenomas in mice,
tumors of the
one depicting Eleuthero roots thyroid gland in rats … and myeloid
around his neck. leukemia in mice induced by indole.
Evidence
The portrait was obtained
was painted in 1991ofbya decrease of transplantability
F. Tushkin) of Ehrlich tumours … and some other transplanted
tumours. A substantial inhibition of the metastasizing
process manifested itself in some cases… These findings
and also radioprotective and antitoxic action towards
anticancer preparations made the use of
Eleutherococcus extract promising in a complex therapy
of cancer carriers.”
42
•Full text:
42

“Eleutherococcus senticosus was experimentally proved
to impede
(His favorite portraithypertrophy
of himself is (ACTH) and atrophy (cortison) of
this the adrenals, hypertrophy and atrophy of the thyroid
gland, to reduce
one depicting Eleuthero rootsthe sugar level in alimentary (glucose)
andneck.
around his adrenal hyperglycaemia and to increase it in
hypoglycaemia
The portrait was painted induced
in 1991 byby insulin.”
F. Tushkin)
43
•Full text:
43

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History of Adaptogens

Dr. Israel I. Brekhman

NOVEMBER 1921 - JULY 1994

(His favorite portrait of himself is

4. Lazarev, N. V., Farmacol. Toxieol., 21, 3, 81-86 (1958)

NOVEMBER 1921 - JULY 1994

(His favorite portrait of himself is

NOVEMBER 1921 - JULY 1994

(His favorite portrait of himself is

NOVEMBER 1921 - JULY 1994

(His favorite portrait of himself is

8. Brekhman, I. I., l v. Si irsk. Ot delenia Akad. Nauk SSSR,9, 113- 22 (1960)

NOVEMBER 1921 - JULY 1994

(His favorite portrait of himself is

NOVEMBER 1921 - JULY 1994

NOVEMBER 1921 - JULY 1994

NOVEMBER 1921 - JULY 1994

NOVEMBER 1921 - JULY 1994

NOVEMBER 1921 - JULY 1994

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