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CHRONIC PAIN
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Student’s Name
Institution Affiliation
Running Head: BRAIN CHANGES ASSOCIATED WITH COGNITIVE FACTORS IN
CHRONIC PAIN
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Brain Changes Associated With Cognitive and Emotional Factors In Chronic Pain
Abstract
The objective of this review was to examine the connection of the brain alterations and pain
The methodology included on line search on PubMed, Embase and web of science for the
original research reports in which 28 eligible papers were included with information on
It was established that pain catasprophizing closely relative to brain areas involved in pain
transmission, attention to pain, emotion and motor activity and to reduced pain recusal.
Important connection with resting state of fMRI data provides that even when not at use, the
Introduction
Chronic pain is determined through a great personal impact with a high prevalence, resulting
in a high socioeconomic costs and low quality of life caused by a long-term sick leave.
There is need to gain the introspection of the underlying mechanism of chronic pain hence
Magnetic Resonance Imaging (MRI) has been the most emerging technique in helping
understand that chronic pain patient shows brain alteration concerning brain structure and
function.
There is need to examine the current research and the relationship between emotional factors
and maladaptive cognitive related to brain and pain alterations measured by Magnetic
Methodology
Registration was done in which a systematic review was held in accordance to PRISMA. This
was followed by literature search strategy where screening PubMed, web of science and
Running Head: BRAIN CHANGES ASSOCIATED WITH COGNITIVE FACTORS IN
CHRONIC PAIN
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Embase. A study selection was then done which was followed by literature being screened by
AM
Results
Reference lists of each paper were screened and searched which resulted to four of the papers
Discussion
Brain alteration is related to various cognitive and emotional factors in patients with chronic
pain. However, it is necessary to take into account the existing gender differences in brain
The main limitation constitutes the application of spearman and Pearson correlations in most
studies when there is need to investigate the relation between brain alterations and
Conclusion
Pain catastrophizing is associated with the processing of pain, pain attention, emotion and
activity of the motor, which is related to the reduced engagement of the descending pain
modulatory system.