In anaemia, retinal changes are liable to occur when
haemoglobin level falls by 50% and are consistently present when it is below 35% (5 gm%). Duration and type of anaemia do not influence the occurrence of retinopathy. Pathogenesis involves factors like anoxia, venous stasis, angiospasm, increased capillary permeability, and thrombocytopenia. Characteristc features of anaemic retinopathy are as below: • Fundus background becomes pale • Retinal arterioles are also pale • Retinal veins are tortuous and dilated • Retinal haemorrhages, superficial flame shaped and preretinal (subhyaloid) may be seen in the posterior half of fundus • Roth spots, i.e., haemorrhages with white center and platelet-fibrin emboli constitute the white centre • Cotton wool spots may also be seen especially in patients with coexisting thrombocytopenia in aplastic anaemia
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