1.

The issue of the study:

An increase in the incidence of congenital hypothyroidism (CH) with a normally located
gland has been reported worldwide. Affected individuals display transient or permanent CH
during follow up in childhood. We aimed to investigate which one is more likely suffering
from transient congenital hypertrophy (CH) or permanent CH who has given low dose of
levotiroxin (LT-4) in the 6 months of age

2. Cohort identification:

3. Identification the variables of the study:

 Independent variable: the dosage of LT-4
 Dependent variable: children before the age of 3 years with transient and permanent
CH who has given LT-4
4. The study’s results analysis:
patients with the transient CH were tended to have lower doses of L-T4 at six months of
age than those suffering from permanent CH.
5. Subjects:

6. Data analysis

 L-T4 dose at 6 months

Transient CH Permanent Total
(+) CH (-)
Lahir 7,1 9,1 16,2
6 Bulan 2,6 3,9 6,5
Total 9,7 14
7,1/16,2
RR= = 1,1
2,6/6,5
  L-T4 dose at 12 months
Transient CH Permanent Total
(+) CH (-)
Lahir 7,1 9,1 16,2
12 Bulan 2,1 3,2 5,3
Total 9,2 12,3

7,1/16,2
RR= = 1,1
2,1/5,3