ADHD Medication (October 4, 2019)

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DOSING SAVINGS
FORMULATIO DURATIO
MEDICATION COMPOUND CONSIDERATION PROGRA
N N
S M

METHYLPHENIDATE

Capsule with
Extended- Capsule may be
multilayer beads;
Adhansia XR® release capsule opened and
20% immediate- 12 hours or
(Adlon 25 mg, 35 mg, contents swallowed N/A
release layer and more
Therapeutics) 45 mg. 55 mg, completely with
80% controlled-
70 mg, 85 mg applesauce
release layer

Capsule with
Extended- multilayer beads;
Capsule may be
release capsule 40% of dose in the
Aptensio XR® opened and
10 mg, 15 mg, immediate-release
(Rhodes 12 hours contents swallowed YES
20 mg, 30 mg, layer and 60% in
Pharmaceuticals) completely with
40 mg, 50 mg, the extended-
applesauce
60 mg release layer (2nd
peak at 7–8 hrs)

Tablet with OROS

osmotic pump
technology; biphasic
release with initial
Must be swallowed
Concerta® or Extended- peak at 1 hr (22% of
whole; non-
generic* release tablet dose) and 78%
12 hours absorbable shell YES
(Janssen and 18 mg, 27 mg, gradual release
may be passed in
others) 36 mg, 54 mg over 9 hrs. Only
stool
Patriot version is
authorized for
substitution for
brand at pharmacy.

Extended- Dissolving tablet

Cotempla release orally with 25%
Grape-flavored,
XRODT™ disintegrating immediate-release 12-13
allow to dissolve in YES
(NEOS tablet microparticles and hours
saliva
Therapeutics) 8.6 mg, 17.3 75% extended-
mg, 25.9 mg release

The time worn can

be varied to control
the duration of
effects; monitor for
Transdermal
Daytrana® Drug dispersed in skin rash or
patch 9 hour
(Noven adhesive layer; sensitivity. Discard YES
10 mg, 15 mg, wear-time
Therapeutics) applied daily patches
20 mg, 30 mg
appropriately. Slow
onset of medication
over initial six
hours.

Delayed release Dual-layer delexis

– Extended delivery: outer layer Taken before going
JORNAY PM™
release capsule delays release for 12 – 14 to sleep to provide
(Ironshore YES
20mg, 40mg, up to 10 hours, hours early morning
Pharmaceuticals)
60mg, 80mg, inner layer controls symptom control
100mg daytime release
 Diffucaps capsule
Extended- Capsule may be
with 30%
release capsule opened and
Metadate CD® immediate-release
10 mg, 20 mg, 8-10 hours contents swallowed
(UCB, Inc.) beads and 70%
30 mg 40 mg, completely with
delayed-release
50 mg, 60 mg applesauce
beads*

Methylphenidat Chewable tablet

Methylphenidate Grape-flavored
e HCI 2.5 mg, 5 mg, 3-4 hours
HCl chewable tablet
(Lupin) 10 mg

Methylphenidat
Extended-
e HCl Methylphenidate Swallow whole; do
release tablet* 6-8 hours
(Mallinckrodt HCl not crush or chew
10 mg, 20 mg
Pharmaceuticals)

Methylin™
Liquid or Colorless, grape-
Oral solution
generic Methylphenidate flavored liquid; store
5 mg/5 mL, 10 3-4 hours
(Shionogi HCl at room
mg/5 mL
Pharma and temperature
others)

Extended-
30% of the dose is
release Cherry-flavored;
Quillichew ER™ immediate-release 12-13
chewable tablet may be taken with YES
(Pfizer) and 70% extended- hours
20 mg, 30 mg, or without food
release
40 mg

Fruit-flavored; may
be taken with or
Extended- 20% of the dose is
without food. Shake
Quillivant XR® release oral immediate-release 12-13
bottle for at least 10 YES
(Pfizer) suspension and 80% extended- hours
seconds. May be
25 mg/5 mL release
stored at room
temperature

Short-acting, Abrupt onset and

Ritalin® or
immediate- offset increase the
generic Methylphenidate
release tablet 3-4 hours number and
(Novartis and HCl
5 mg, 10 mg, 20 severity of side
others)
mg effects

Capsule with
Spheroidal Oral
Drug Absorption
Extended- Capsule may be
System (SODA S)
release capsule opened and
Ritalin LA® technology; 50%
10 mg, 20 mg, 8-12 hours contents swallowed
(Novartis) immediate-release
30 mg, 40 mg, completely with
beads and 50%
60 mg applesauce
delayed-release
(2nd peak 4 hrs
later)*

Tablets should be
Sustained-
Ritalin SR® Methylphenidate swallowed whole,
release tablet 8 hours
(Novartis) HCl never crushed or
20 mg
chewed

DEXMETHYLPHENIDATE

Focalin® or Short-acting, 4-6 hours Isolated active

Dexmethylphenidat
generic immediate- dextroisomer; give
(Novartis and release tablet* e Hydrochloride approximately 1/2
others) 2.5 mg, 5 mg, methylphenidate
10 mg dose

Capsule with SODA

Extended- S technology; 50%
Capsule may be
Focalin XR® or release capsule of the beads
opened and beads
generic 5 mg, 10 mg, 15 contained in the
8-12 hours swallowed YES
(Novartis and mg, 20 mg, 25 capsule are
completely with
others) mg, 30 mg, 35 immediate-release
applesauce
mg, 40 mg and 50% are
delayed-release*

AMPHETAMINE

Orange-flavored;
may be taken with
Extended- 50% immediate-
Adzenys ER™ or without food.
release oral release and 50% 10-12
(Neos Shake bottle YES
suspension delayed-release hours
Therapeutics) vigorously before
1.25 mg/ml particles
dispensing the
dose.

Extended-
release orally
Dissolving tablet
Adzenys XR- disintegrating
with 50%
ODT™ tablet 10-12 Allow tablet to
immediate-release YES
(Neos 3.1 mg, 6.3 mg, hours dissolve in saliva.
and 50% delayed-
Therapeutics) 9.4 mg, 12.5
release particles
mg, 15.7 mg,
18.8 mg

Bubblegum flavor;
may be taken with
Extended-
or without food.
Dyanavel® XR release oral Oral solution with
13 hours Shake bottle before YES
(Tris Pharma) suspension bubblegum flavor
preparing the dose.
2.5 mg/ml
May be stored at
room temperature

DEXTROAMPHETAMINE

Dexedrine®
Short-acting
(Amedra Dextroamphetamine Take first dose on
tablet 3-4 hours
Pharmaceuticals Sulfate awakening
5 mg, 10 mg
and others)

Dextroamphetamine
Sulfate delivered in
Extended- a sustained-release
Dexedrine ER®
release spansule. Initial
(Amedra
spansule dose released 5-10 hours
Pharmaceuticals
5 mg, 10 mg, 15 immediately,
and others)
mg remaining
medication released
gradually.

ProCentra® and
Bubblegum flavor;
generic
may be taken with
(Independence Oral solution Dextroamphetamine
3-6 hours or without food. YES
Pharma, Tris 5 mg/5 mL Sulfate
Shake bottle before
Pharma, and
preparing the dose.
others)
May be stored at
 room temperature

Immediate-
release tablet
Zenzedi®
2.5 mg, 5 mg, Dextroamphetamine Take first dose on
(Arbor 4-6 hours YES
7.5 mg, 10 mg, Sulfate awakening
Pharmaceuticals)
15 mg, 20 mg,
30 mg

METHAMPHETAMINE

Desoxyn®
Immediate-
(Recordati Rare
release tablet Methamphetamine 4-6 hours
Diseases and
5 mg
others)

MIXED AMPHETAMINE SALTS

Dextroamphetamine
Short-acting,
Saccharate,
immediate-
Adderall® or Amphetamine
release tablet
generic Aspartate, May be taken with
5 mg, 7.5 mg, 4-6 hours
(CorePharma Dextroamphetamine or without food
10 mg, 12.5 mg,
and others) Sulfate and
15 mg, 20 mg,
Amphetamine
30 mg
Sulfate

Capsule with
Extended-
Adderall® XR or Microtrol delivery Capsule may be
release capsule
generic system: 50% 10-12 opened and beads
5 mg, 10 mg, 15
(Takeda and immediate-release hours swallowed whole
mg, 20 mg, 25
others) and 50% delayed- with applesauce
mg, 30 mg
release beads*

Long-acting Long-acting, triple- Capsule may be

Mydayis® capsule bead, mixed 14-16 opened and beads
YES
(Takeda) 12.5 mg, 25 mg, amphetamine salts hours swallowed whole
37.5 mg, 50 mg formulation with applesauce

AMPHETAMINE SULFATE

50 percent
Evekeo® Immediate-
dextroamphetamine
(Arbor release tablet 4-6 hours YES
and 50 percent
Pharmaceuticals) 5 mg, 10 mg
levoamphetamine

LISDEXAMFETAMINE

Capsule may be
Long-acting
opened and
capsule
Lisdexamfetamine contents dissolved
Vyvanse® 10 mg, 20 mg, 10-13
Dimesylate; peaks in water, yogurt, or YES
(Takeda) 30 mg, 40 mg, hours
in 3.5 hrs* orange juice; use
50 mg, 60 mg,
immediately after
70 mg
dissolving

Chewable tablet
10 mg, 20 mg, Lisdexamfetamine Strawberry flavored;
Vyvanse® 10-13
30mg, 40 mg, Dimesylate; peaks may be taken with
(Takeda) hours
50 mg, and 60 in 3.5 hrs* or without food
mg
 ATOMOXETINE

Selective
norepinephrine
inhibitor. Starts
working in a few
Long-acting days to one week,
capsule but may take
Strattera® and
10 mg, 18 mg, several weeks to
generics All day atomoxetine 24 hours YES
25 mg, 40 mg, achieve full effect.
(Lilly)
60 mg, 80 mg, Swallow capsule
100 mg whole; powder is
irritating. Dose is
commonly divided
in two to lower side
effects

CLONIDINE

Kapvay® and
generic clonidine Extended-
Clonidine Swallow tablet
ER release tablet 24 hours
Hydrochloride. whole
(Advanz 0.1 mg, 0.2 mg
Pharmaceuticals)

GUANFACINE

Swallow tablet
whole; a high-fat
Intuniv™ or Extended-
meal may increase
generic release tablet
Guanfacine 24 hours absorption and lead YES
(Takeda and 1 mg, 2 mg, 3
to toxicity. FDA -
others) mg, 4 mg
approved for doses
up to 7 mg

BUPROPION

Low efficacy; takes

8 weeks to fully
Wellbutrin XL® Extended- develop benefits. IR
(Valeant release tablet Bupropion HCL 24 hours dosed 3 times a YES
Pharmaceuticals) 150mg, 300mg day; SR dosed 2
times/day; XL
dosed once a day.