Professional Documents
Culture Documents
Benefits of Exercise
Data from multiple studies that have examined the
relationship between physical fitness and mortality
From the Northwestern Memorial Hospital, Chlcago, Illinois (EW); lJn~- indicate that moderate levels of fitness are associ-
verslty of California, San Francisco, California (NB); Long Beach Memo-
real Hospital, Long Beach, Callfornla (SAB); and Medical College of Ohio,
ated with a large reduction in the risk of adverse
Toledo, Ohlo (HEMI. events, including mortality, although the reduction
Requests for reprints should be addressed to Edward Winslow, MD, is less than that seen with greater levels of fitness
Department of Medicine, Northwestern Memorial Hospital, 211 East Chi-
cago Avenue, Suite 930, Chicago, lllrnois 60611. (Figure 1) .‘.“,’ The major prot,ective effect of phys-
ical fitness is a reduction in cardiovascular events6
TABLE I 2.00% r
Not surprisingly, physical fitness has little impact on duced with exercise. Regular exercise transforms
mortality from trauma. small, dense atherogenic LDL particles to more de-
Recently published data from Blair et al” showed sirable, more buoyant LDL particles. Exercise also
that previously unfit individuals who became fit over affects intermediate-density lipoprotein cholesterol
a Z-year period had a reduced risk of mortality fractions in such a way as to decrease the likelihood
as compared with those who remained unfit of further atherosclerosis. In addition to these favor-
(Figure 2 ) . On the ot,her hand, initially fit subjects able effecm on the serum lipid profile, exercise pro-
who became unfit during follow-up lost much of the tects against t,he adverse effects of hyperlipidemia
benefit associated with fitness. These findings sug- on the arterial wall.”
gest t,hat the process of achieving fitness has a major Evidence obtained in bot,h humans and animals
beneficial effect in helping to reduce the risk of car- shows that regular exercise also decreases the det-
diac events. Similar findings have been reported in rimental effects of catecholamines on the myocar-
primary prevention trials and coronary rehabilitation dium.‘O,l’ Regular exercise is also associated with a
studies.“,J.7-8 small but predictable reduction in arterial blood
A number of beneficial effects may contribute to pressure. The magnitude of this reduction is similar
the favorable impact of exercise on cardiovascular to the reduct.ion expected w&h diuretic therapy,
risk. Exercise improves serum lipid fractions, both about 5- 10 mm Hg systolic ant1 about, 5 mm Hg di-
in diabetic and nondiabetic individuals. High-den- astolic.“‘~‘”
sity-lipoprotein (HDL) cholesterol increases in re- Exercise can also play an import,ant role in weight
sponse to exercise, while low-density-lipoprotein loss and weight control.
(LDL) cholesterol shows no change or a small re- Results of multiple cross-sectional studies indicate
duction. Triglyceride levels are also markedly re- that exercise decreases the likelihood of developing
60
50 q High
g 40
e
r” 30
20
0
Blair (1989)’ Sandvik (1993)2 Siskovick (1978)s
Study Group
4A-26s October 8, 1996 The American Journal of Medune” Volume 101 (suppl 4A)
SYMPOSIUM ON CORONARY AND OTHER VASCULAR DISEASE/WINSLOW ET AL
diabetes. In the Physicians Health Study, partici- gree of blood-pressure reduction, should be em-
pants who exercised regularly had a dramatically ployed to assess patient. progress. Reaching the goals
lower incidence of diabetes than those who did not.‘” that have been set can encourage patients to con-
Similar findings were reported in the Nurses Health tinue exercising. If the goals are not met, the pro-
Study.‘” gram should be reassessed and adjustments made in
The beneficial effects of physical activity (and per- order to overcome the obstacles to success.
haps of dietary modification as well) are illustrated
by the differences between two tribes of Pima Indi- Pre-exercise Evaluation
ans, considered to be genetically predisposed to di- The evaluation of a patient who is about to begin
abetes, one tribe living in Arizona and the other liv- an exercise program should include a history of past
ing in the highlands of Mexico. The Pima Indians in exercise habits and any current limitations to exer-
Arizona are obese, hypertensive, and diabetic, and cise, such as symptoms of coronary disease, claudi-
have a high incidence of vascular disease. In con- cation, back pain, or previous injuries. A physical
trast, those living in the Mexican highlands, where examination and laboratory evaluation will help in
food is less abundant and work more strenuous, identifying high-risk individuals with elevated blood-
have no hypertension, diabetes, or central obesity. I5 pressure levels and/or lipid abnormalities.
In addition to these clinically substantiated bene- The need for exercise testing prior to initiation of
fits, experimental studies have shown that regularly an exercise program has been debated. Exercise
exercised animals have a dramatically better out- testing of everyone beginning an exercise program
come after exposure to myocardial ischemia than an- is impractical. Rather, physicians should be selective
imals that are not exercised.‘” Data from Ehsani et in determining which patients are appropriate can-
al I7 suggest, but do not prove, that this is the case in didates. The need for evaluation might best, be de-
humans as well. termined by assessing the presence of such risk fac-
tors as older age, male gender, family history of
Prescribing Exercise premature atherosclerosis, smoking, hypercholester-
In helping to set up a fitness program, the physi- olemia, hypertension, diabetes, and marked 0besit.y.
cian should discuss with the patient how the pro- Patients with established heart disease are clearly in
gram can be set up and what types of exercise might need of exercise testing before beginning an exercise
be considered. Patients should identify training ac- program.
tivities that are most acceptable to them and most
likely to be carried out on a regular basis-e.g., run- Formal Exercise Programs
ning, walking, climbing stairs, biking, rowing, cross- It is unclear whether patients need “formal” pro-
country skiing, skating, dancing, swimming. A spe- grams. Some data suggest that self-directed exercise
cific time of day should be set aside for exercise, e.g., may be as effective as formal programs in patients
either before or after work. who are at. lower risk.18 Nonetheless, there is evi-
Patients embarking on an exercise program dence that some patients, especially those at higher
should start slowly, especially if they have been sed- risk, may benefit from medically monitored exercise
entary: 10 minutes of exercise each day is recom- programs. lWO Thus, patients who fit into the “high-
mended initially, although 20 minutes per day may risk” groups should at least, st,art training in a pro-
be appropriate for an individual who has a more ac- gram. High-risk patients include those with severe
tive lifestyle. Increases in exercise duration should exercise-induced arrhythmias, evidence of severe
be in small increments of 5-10 minutes daily each ischemia on provocative test,s (>2 mm ST depres-
week until a total exercise time of 30-40 minutes/ sion, exercise-induced hypotension, or large perfu-
day is reached. sion defects on perfusion test,ing, if perfusion testing
Insist that patients exercise 5 days each week. If is performed), poor exercise capacity ( < 7 METS or
one or two sessions are missed, the patient. will still less than stage 2 of a Bruce exercise t,est), or sur-
have managed at least 3 or 4 days of exercise. The vivors of cardiac arrest. A program may also be con-
speed at which exercise is performed is not neces- sidered for the initial (first 4- 12 weeks) exercise
sarily important; the regularity with which it is per- training after an event (MI, or revascularization).
formed is important.
Goals should be set and systems devised for mon- SMOKING CESSATION
itoring these goals. Follow-up can be very simple, The healt,h hazards of smoking are well docu-
using such devices as charts or calendars to monitor mented. Smokers experience four times the risk of
compliance and progress with the exercise program. death from all cardiovascular disease and three
Objective measures of the patient‘s accomplish- times the risk of death from coronary artery dis-
ments, such as the amount, of weight lost or the de- easem21
October 8, 1996 The American Journal of Medicine” Volume 101 Isuppl 4A) 4A-27s
SYMPOSIUM ON CORONARY AND OTHER VASCULAR DISEASE/WINSLOW ET AL
0 Current smoker
Smoking accounts for approximately 21.5% of drink a cup of coffee or an alcoholic beverage, make
deaths from coronary artery disease and 18% of a phone call, or finish a meal. Nicotine dependence
deaths from st,roke.2’ The risk of chronic obstruct,ive is also reinforced by various external cues, such as
pulmonary disease is increased lo-fold in smokers. advertisements, societal attitudes, and overt or cov-
The risk of various cancers, including lung, oral, ert messagessuggesting that smoking is glamorous,
esophageal, renal, and bladder cancer is also in- sophisticated, “macho,” or “cool.”
creased by smoking.
There is extensive evidence that smoking cessa- Smoking Cessation Strategies
tion reduces the risk of mortality and morbidity from For more than a decade, the C.S. Public Health
coronary artery disease. Even individuals who Service has identified smoking as the most important
smoke less than half a pack a day (I -9 cigarettes preventable cause of death in this country. It has also
daily) are at greater risk of death from coronary characterized smoking cessation as the single most
artery disease than lifelong nonsmokers (Figure important step that smokers can take to enhance the
3).“” Reduction in cardiovascular risk begins im- length and quality of their lives.2’i
mediately after smoking cessation and continues There are various strategies that can be used to
over time. Within 5-10 years after cessation, the promote smoking cessation, including advice from a
risk is reduced to a level almost equivalent, to that physician, nicotine replacement, therapy, behavior
in nonsmokers.‘2’4 The risk of death from coro- modification, and smoking cessation programs. The
nary artery disease rises as the number of ciga- challenge is to implement these strategies univer-
rettes smoked daily increases.‘!’ Quitting, however, sally and consistently so that smokers who could be
provides substant,ial reductions in risk at any level helped to quit do not “slip through” the healthcare
of cigarette consumption. system unnoticed and untreated. Physicians are in
an excellent position to help their patients stop
Smoking as an Addiction smoking. With an estimated 70%of U.S. smokers see-
Despite public awareness of the health risks of ing a physician at least once a year,“’ physicians
smoking, millions of U.S. citizens continue t.o smoke, have the opportunity to reach an estimated 38 mil-
largely because they are physically and psychologi- lion of 50 million smokers with t,he messageto quit.
cally dependent on nicotine, the addicting drug in A Z-minute physician intervent,ion consisting of ques-
tobacco.“’ Continued smoking is also strongly asso- tioning patients about smoking, advising them to
ciated with physical and psychological effects that quit, and providing educational materials, along with
are perceived to be pleasurable-such as skeletal/ appropriate follow-up, has been found to result in a
muscular relaxation, electrocortical stimulation, 5% quit rate at the end of 1 year.“7 This percentage
stress reduction, and oral and tactile gratification- translates into 25 exsmokers per U.S. physician each
as well as with behavioral cues t,hat reinforce nico- year. Even if only 10% of the 550,000 physicians in
tine dependence. Smokers frequently regard the the United States achieved this goal, approximately
bond between the cue and the cigarette as a unit that 1?250,000persons would stop smoking annually.
is difficult to break until the cue is identified as sep- When advising a patient to quit smoking, the phy-
arate and distinct from smoking. Many smokers, for sician should first review the stages of change iden-
example, automatically have a cigaretl,e when t,hey tified by Prochaska and DiCllemente”” to ascertain
4A-28S October 8. 1996 The American Journal of Medicine” Volume 101 (suppl 4A)
SYMPOSIUM ON CORONARY AND OTHER VASCULAR DISEASE/WINSLOW ET AL
October 8, 1996 The American Journal of Medicine’R Volume 101 Isuppl 4A) 4A-29s
SYMPOSIUM ON CORONARY AND OTHER VASCULAR DISEASE/WINSLOW ET AL
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SYMPOSIUM ON CORONARY AND OTHER VASCULAR DISEASE/WINSLOW ET AL
7. Pate RR, Pratt M, Blair SN, et al. Physrcal actrvrty and public health: a rec- DISCUSSION HIGHLIGHTS
ommendatron from the Centers for Disease Control and Preventron and the
American College of Sports Medrcrne. JAMA. 1995;273:402-407. Harry E. Mayhew, MD (Toledo, Ohio ) : We have
8. McHenry PL, Ellestad MH, Fletcher GF, Froelicher V. Statement on exercise: a lot of ground to cover discussing lifestyle modifi-
a position statement for health professtonals by the committee on exercise and cation-diet, exercise, smoking cessation, and
cardiac rehabilitation of the AHA. Crrculation. 1990;81:396-398, stress reduction. I would like to begin by reinforcing
9. Kramsch DM, Aspen AJ, Abramowitz BM, Kreimendahl T, Hood W, Reduction
the value of the 3- or 7-day diary to record eating
of coronary atherosclerosis by moderate conditioning exercise in monkeys on
an atherogenic diet. N Engl .J Med. 1981;305:1483-1489.
habits for patients initiating a dietary program. The
10. Duncan JJ, Farr JE. Upton J, et al. The effects of aerobic exercrse on nutritionist or dietitian can then use this list to sug-
plasma catecholamines and blood pressure in patients with mild essential hy- gest substitutions that are lower in sat,urated fat and/
pertension. JAMA. 1985;254:2609. or cholesterol, yet are still nutritious. The ‘i-day diary
11. Ginsburg GS, Agrl A, D’Toole M, Rimm E, Douglas PS, Rifai N. Effects of a
may also reveal what the Framingham Study referred
single bout of ultrendurance exercise on lipid levels and susceptrbilrty of lipids
to peroxidation in triathletes. JAMA. 1996;276:221-225. to as the IO-meal concept- that most people tend to
12. Choquette G, Ferguson RJ. Blood pressure reduction in “borderline” hy- eat the same 10 meals again and again, with occa-
pertensrves following physical training. Can Med Assoc J. 1973;108:699. sional variations and additions.
13. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens Neil J. Stone, MD ( Chicago, Illinois ) : We stress
CH. A prospective study of exercrse and incidence of diabetes among US male
attitude, knowledge, and skills in our dietary inter-
physicians. JAMA. 1992;268:63-67.
14. Manson JE, Rimm EB, Stampfer MJ, et al. Physrcal activity and incidence of
vention programs. However, before offering advice,
non-rnsulrn-dependent diabetes mellrtus in women. Lancet. 1991;338:774-778. we try to determine whether the patient is ready to
15. Ravussin E, Valencia ME, Esparza J, Sennett PH, Schulz LO. Effects of a make a change. Those who are ready are more likely
traditronal lifestyle on obesrty in Prma Indians. Diabetes Care. 1994;17:1067- to be compliant, but some patients are not ready to
1074. change. We use books rather than handouts for pa-
16. Darrah MI, Engen RL. Beneficial effects of exercise on L-isoproterenol in-
tient education. 1 have lo-15 cookbooks and diet
duced Ml In male rat. Med SCI Sports Exercrse. 1982;14:76.
17. Ehsanr AA, Heath GW, Hagberg JM, et al. Effects of 12 months of intense books that patients can browse through while they
exercise training on rschemic ST-segment depression in patients with coronary are waiting for an appointment,. Many of my patients
artery disease. Crrculation. 1981;64:1116. like to photocopy recipes from these books and take
18. King AC, Haskell WL, Taylor CB, Kraemer HC, DeBusk RF. Group vs. home- them home. Having this type of information available
based exercise training rn healthy older men and women: a communrty-based
can be part of the educational process. Patients are
clinrcal trral. JAMA. 1991;226:1535-1542.
19. Greenland P. Efficacy of supervised cardiac rehabilitation programs for often reluctant to consult a dietitian because it is
coronary pabents: update 1986 to 1990. J Cardiopulmonary Rehab. costly and not reimbursed by third-party payers. I
1991;11:197-203. ask my patients how much they spend each month
20. Van Camp SP, Peterson RA. Cardrovascular complications of outpabent at the pharmacy for over-the-counter vitamin supple-
cardiac rehabilitation programs. JAMA. 1986;256:1160.
ments and home remedies. When they add up these
21. U.S. Department of Health and Human Services. Strategies to Control To-
bacco Use in the United States: a blueprint for Public Health Action in the 1990s. costs, they find that they spend a substantial amount
U.S. Dept of Health and Human Services. 1991;NIH Publicatron No 92. on these products, easily enough to pay for dietary
3316,1991. counseling, which theoretically might provide more
22. U.S. Department of Health and Human Services. Reducing the Health Con- substantiated and long-term benefits.
sequences of Smoking: 25 Years of Progress. A Report of the Surgeon General,
Edward Winslow, MD (Chicago, Illinois): Two
1989. U.S. Dept of Health and Human Services; 1989. Publrcatron CDC 898411.
23. Rogot E, Murray JL. Smoking and causes of death among U.S. veterans: obstacles that stand in the way of lifestyle changes
16 years of observation. Public Health Reports. 1980;95:213-222. are unrealistic expectations that our patients will
24. U.S. Department of Health and Human Services. The Health Benefits of make changes immediately and inadequate follow-
Smoking Cessation. A Report of the Surgeon General, 1990. U.S. Oept of Health up. Most lifestyle changes will be abandoned unless
and Human Services; 1990. Publication CDC 90-8416.
they are reinforced frequently as part of the follow-
25. US. Department of Health and Human Services. The Health Consequences
of Smoking: Nicotine Addiction. A Report of the Surgeon General, 1988. U.S. up evaluation. Instead of asking, “How much chest
Dept of Health and Human Services; 1988. Pubhcatron CDC 88-8406. pain are you having?” you might ask, “How is your
26. U.S. Department of Health and Human Services, Public Health Service, exercise program going?” Then you can review how
National Institutes of Health: Clinical Opportunitres for Smoking Intervention. NIH they felt when they were exercising or dieting. They
Publication No 86-2178, August 1986.
almost always admit that they did feel better and
27. Russell MAH, Wrlson C, Taylor C, Baker CD. Effects of general practitroners’
advice agarnst smoking. Br Med J. 1979;2:231-235. continue with the exercise or diet regimen.
28. Prochaska JO, DrClemente CC. Stages of change in the modification of Elliot Rapaport, MD (San Francisco, Califor-
problem behaviors. Prog Behav Modrf. 1992;28:183-218. nia): Simply getting a person out of the tense envi-
29. Brunton SA, Henningfield JE, Solberg LI. Smoking cessation: what works ronment of the workplace may contribute to the ben-
best? Patient Care, June 15, 1991.
efits associated with exercise. I think we have
30. Fiore MC, Barley WC, Cohen SJ, et al. Smoking Cessation. Clinical Practice
Guideline No 18. Rockville, MD: U.S. Department of Health and Human Services,
perhaps underplayed the issue of stress relief.
Public Health Service, Agency for Health Care Policy and Research. AHCPR Alan H. Heaton, PharmD ( St. Paul, Minnesota) :
Publicatron NO. 96-0692. April 1996. In a primary-care HMO environment, you have about
October 8, 1996 The American Journal of Medicine” Volume 101 (suppl 4A) 4A-31s
SYMPOSIUM ON CORONARY AND OTHER VASCULAR DISEASE/WINSLOW ET AL
4.3 minutes per patient to make recommendations. some parts of the world, physicians actually smoke
The key in that setting is to solicit ancillary support more than the general population, although, fortu-
personnel to assist with patient follow-up. We have nately, this is much less of a problem in the United
a smoking-cessation program that involves incre- States. Physicians who smoke in the office convey
mental dispensing of nicotine patches at Z-week in- the wrong messageto their patients.
tervals. Patients must return every 2 weeks and show Dr. Stone: I have a question for Dr. Winslow. In the
that they have attended the smoking cessation class. Lifestyle Heart Trial, the only death in the experi-
We have had a l-year smoking cessation rate of 46% mental group occurred in a person who exercised
in that group. The same principle applies to dietary too much. In the Heidelberg Trial, two deaths were
modification and exercise. The patient motivation is- due to excessive exercise. How do you manage a
sue is key, especially in the primary-care environ- patient who appears to be exercising too exces-
ment. In the managed-care environment, the ern- sively, despitth having heart disease?
ployer must be convinced of the benefits of such Dr. Winslow: A commonly held belief in the United
interventions and be willing to pay for them. Some- States is that if something is good, more is better.
times the messageof the value of these interventions That is not necessarily true. I try to get my patients
gets lost when it must be expressed in terms of ben- to tell me why they are doing more than they have
efit to the employer. to. If that objective is improved health, I point out
Dr. Mayhew: It is important that the physician not why more is not necessary.
overwhelm the patient who has just experienced a William Hazzard, MD (Winston Salem, North
coronary event. Instead of presenting him or her Carolina) : The dose-response relationship is clear.
with an extensive lifestyle modification program, The greatest benefit is derived from moderate exer-
you should set smaller goals. In dealing with smok- cise relative to the number of calories expended. The
ers, I have found that it is much better to determine incremental or marginal benefit from h&$-level ex-
first the patient’s opinion of smoking and level of ercise is less per calorie expended, and the risks be-
commitment to a program. I have never had a patient gin to increase. As people age, they become fearful
who stated that smoking was beneficial. Then I ask about starting to exercise. We have mounted a spe-
how I can help. This approach makes me an ally cific program to try to overcome that fear among
rather than an adversary. If the patient does not want older people through t,hr use of videotapes and other
to deal with the issue of smoking at this time, I then forms of communication. Keluctance to start and, to
ask when it would be appropriate to discuss the mat- some extent, the fear of beginning may be the most
ter again. In this way we set up contracts for moti- difficult first barriers to exercising.
vation, education, initiation of a cessation program, Dr. Mayhew: Even if physicians have training in
or monitoring success. diet, nutrition, and lifestyle modifications, they fre-
Dr. Heaton: We are seeing a tremendous rise in quently do not have enough time to extensively
the use of chewing tobacco, especially in OUT counsel patients. It is important that physicians, es-
young, male, rural population. Are there any long- pecially in the smaller communities, have a resource
term data on the risks associated with chewing to- person, such as a dietitiarl at the hospital or a nurse
bacco? in the office, who will learn more about lifestyle
Dr. Winslow: There are some data that smokeless modifications and interact with patients.
tobacco can increase the level of some risk f;ztors Dr. Hazzard: Residents in internal medicine are
for atherosclerosis.’ There are also data from the often uncomfortable in their role as patient edu-
Surgeon General that indicate an increased risk for cators and members of a team. They do not yet
oropharyngeal cancers with the use of chewing to- know how to communicate with dietitians because
bacco.’ they do not necessarily speak the same language.
John Noble, MD (Boston, Massachusetts): In In the managed-care environment, the physician is
discussing smoking cessation, special teaching pro- not the primary person who delivers the lifestyle
grams and banning of advertisements were men- modification message and cert,ainly not the rein-
tioned. With all of our interventions, we may want forcer of that message, but he or she does need to
to try to push beyond the prescription pad. It may initiate it and support those who do deliver the
be difficult in an academic medical cent,er, but more message. Consequently, development of team be-
opportunities may exist. in a smaller community. For havior and communication skills is important. In
example, physicians might get patients into an ex- smaller practices, you must find other health pro-
ercise program by inviting them to join a group for fessionals in the community who will work with
walks in the mountains. you as a team.
Dr. Rapaport: We should not ignore the role of the Dr. Stone: Unfortunately, we are sharing the spot-
physician as a role model in lifestyle modification. In light with people making recommendations, such as
4A-32S October 8, 1996 The American Journal of Medlclne@ Volurne 101 (suppl 4A)
SYMPOSIUM ON CORONARY AND OTHER VASCULAR DISEASE/WINSLOW ET AL
megavitamin therapy, lmsed on unsubstantiated con- vice from others, and information from a physician.
clusions. One of the public policy issues facing us Other barriers to compliance include cost, the wait-
today is how to deal with the zealous crusaders who ing time in the physician’s office, the complexity of
promote t.hese unsubstantiated health claims. We the regimen, the side effects of treatment, and the
must take back the pulpit. quality of the physician-patient relationship. The
Dr. Mayhew: These changes definitely constitute a doctor serves as the patient’s coach to educate and
barrier to the implementation of effective lifestyle motivate him or her to adopt good healthcare prac-
modifications. However, thrre are other barriers that tices.
we should also be concerned about. According to the
Health Belief Model, several factors can modify a pa- REFERENCES .__ __- -~.---._lll-
1. Bolmder, GM, Ahlborg BO, Llndell JH. Use of smokeless tobacco: blood-
tient’s perceptions of the threat of disease and bar-
pressure elevation and other health hazards found In a large-scale population
riers to proposed treatment, thus modifying compli- survey. J Intern Med. 1992;232:327-334.
ance. They include race, age, gender, ethnic origin, 2. McCann D. Surgeon general warns agalnbt use of smokeless tobacco. JAm
personality, social class, socioeconomic status, ad- DentAssoc. 1993;124:22.
October 8, 1996 The American Journal of Medlclne’ Volume 101 (suppl 4A) 4/i-33s