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Homeremedies PDF
ISSN(print): 2589-868X
ABSTRACT:
Obesity, a complex interplay between environmental and genetic factors and is associated with
significant morbidity and mortality. Usage of herbs for the management of obesity in the recent times is
attracting attention. A web and man-ual based literature survey was conducted to assess the amount of
information available on the herbal products for weight management. Traditional literature, PubMed,
Scopus, Google scholar databases were screened up to February 2012. The search words were “obesity”,
“herbal medicine/products/extracts”, “medicinal plants”, “traditional medicine”, Obesity in adults is
characterized when the Body Mass Index (BMI) is greater than or equal to 30. It is estimated that 1.7
billion people in the world are overweight or obese, and more than one third of U.S. adults (35.7%) are
obese. There are a variety of factors that play a role in obesity, such as behavior, environment, and
genetic factors. Usual countermeasures include adequate physical activity, avoidance of calorie-dense
foods, and use of certain drugs for promoting weight loss. Surgery is an extreme measure and anyone
considering it must have failed consistently in losing weight through lifestyle changes and less invasive
methods. The main drugs currently employed in obesity treatment present dangerous side effects,
namely: elevation of blood pressure, insomnia, constipation, headaches, among others. For this reason, a
wide variety of natural materials have been explored for their obesity treatment potential. Considering
that natural anti-obesity products have different mechanisms, the recommended approach to research a
more effective obesity treatment, reaching the associated synergistic effects, must involve the
combination of natural products and/or products with multiple activities. This chapter describes several
natural products with anti-obesity activity, and active components and mechanisms of action to combat
obesity.
Keywords: anti-obesity activity, metabolic syndrome, natural products, obesity
myriad of genetic, dietary, lifestyle, and in treatment of obesity, diabetes and other chronic
environmental factors, which favors a chronic diseases.
positive energy balance, and leads to increased
Adults
body fat mass. The incidence of obesity is rising
at an alarming rate and is becoming a major For adults, WHO defines overweight and obesity
public health concern with incalculable social as follows:
costs. Indeed, obesity facilitates the development • Overweight is a BMI greater than or equal to
of metabolic disorders such as diabetes, 25; and
hypertension, and cardiovascular diseases in
addition to chronic diseases such as stroke, • Obesity is a BMI greater than or equal to 30.
osteoarthritis, sleep apnea, some cancers, and BMI provides the most useful population-level
inflammation-based pathologies. Both lifestyle measure of overweight and obesity as it is the
and pharmacotherapy interventions have been same for both sexes and for all ages of adults.
considered by physicians and other health care However, it should be considered a rough guide
professionals as obesity treatment modalities. because it may not correspond to the same degree
Studies show that only 5-10% subjects can of fatness in different individuals.
maintain their weight loss over the years . The
complex pathogenesis of obesity indicates the For children, age needs to be considered when
need of different intervention strategies to defining overweight and obesity.
confront this problem with a simple drug therapy Children under 5 years of age
which is more acceptable to patients .
For children under 5 years of age:
Disappointing results, after cessation the lifestyle
modification or pharmacotherapy indicated the • overweight is weight-for-height greater than 2
need of other treatment modalities to produce standard deviations above WHO Child Growth
better and long-lasting results, in terms of weight Standards median; and
loss . Herbal supplements and diet-based • Obesity is weight-for-height greater than 3
therapies for weight loss are among the most standard deviations above the WHO Child
common n complementary and alternative Growth Standards median.
medicine [CAM] modalities. A vast range of
these natural products and medicinal plants, Children aged between 5–19 years
including crude extracts and isolated compounds Overweight and obesity are defined as follows for
from plants can be used to induce weight loss and children aged between 5–19 years:
prevent diet-induced obesity. In the recent
decades, these have been vastly used in • overweight is BMI-for-age greater than 1
management of obesity due to containing a large standard deviation above the WHO Growth
variety of several components with different anti- Reference median; and
obesity and anti-oxidant effects on body • Obesity is greater than 2 standard deviations
metabolism and fat oxidation. Medicinal plants above the WHO Growth Reference median.
have been investigated and reported to be useful
FIG:-1
2
Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
Definition and Epidemiology and the IMC also change with height and age.
Calculating body mass index (BMI), also known Obesity is 541 Journal of Food and Nutrition
Research considered when the percentage above
asquetelet index is defined by dividing the mass
95% of BMI for age and sex. Excess fat can be
(Kg) by the square of the height (m) – it is the
located in the abdominal area, which is defined as
epidemiological indicator for the diagnosis of
android-type obesity, central obesity, abdominal
overweight and obesity. According to the adapted
classification by the World Health Organization obesity or apple shaped, showing a high risk of
cardiovascular complications when compared to
(WHO), obesity is defined by a BMI greater than
gynecoid obesity, inferior obesity, peripheral
or equal to 30 Kg/m2. The presence of
obesity, gluteal-femoral (i.e. the pear shape)
overweight or obesity increases the risk of
which the fat is concentrated in the region of the
comorbidities, there is an association between
hips.
BMI and mortality or chronic diseases. The
definition of infant obesity it´s more complicated
TABLE 1: Classification of obesity according to BMI (Kg/m2) and the risk of disease
DIAGNOSING OVERWEIGHT/OBESITY
Body Mass Index (BMI): Overweight and Obesity are assessed using Body Mass Index
(BMI). It is defined as a person's weight in kilograms divided by the square of his / her height in meters
(kg/m2).
FIG:-2
2. Lack of interest in doing work. Fat patients with weak heart. For women who are
3. Profuse sweating with foul body odor. tired and weary and take cold easily and lead a
sedentary life. Dry coryza and stoppage of the
4. Excessive hunger. nose, chiefly at night, with danger of suffocation.
5. Feeling of tiredness. With long continued coryza, can only breathe
through the mouth. Women with premature and
6. Excessive sleep too copious menses, with emission of black and
Ayurveda: acrid blood. Sadness, with disposition to weep.
Timidity of character. Disgust with life.
In Ayurveda, Atisthaulya (Obesity) is described Heedlessness. Great absence of mind and
as excessive accumulation of Meda (fat/adipose weakness of memory. Vertigo, on reading in a
tissue) and Mamsa (flesh/muscle tissue) leading sitting posture. Chilly patient with great
to flabbiness of hips, abdomen, and breast. It is sensitiveness to cold open air, < in wet, stormy
considered as one of Santarpanottha Vikaras weather ; from washing ; > by warmth.
(disease due to consumption of excessive
calories) in Ayurveda. Medodushti (disorders of 2. AMMONIUM MUR.
fat metabolism) may be one of the risk factors for In case the body is fat and legs are thin. With
Ischemic Heart Disease (IHD). large buttocks. Full of grief, but cannot weep.
AYURVEDIC MANAGEMENT LINE OF Irritability and disposition to be angry. Very
TREATMENT severe ulcerative pain in the heel, > by rubbing.
The feet get very cold in the evening in bed.
(Under strict supervision of Registered
Ayurvedic Physician) Shamana (Palliative) 3. ANTIMONIUM CRUDUM.
treatment: Children and young person with tendency to grow
Langhan (Fasting), fat with coated moist white tongue. The subject
Ama pachan (oral use of digestives to needing this remedy may belch a great deal, and
augment the fat metabolism), the eructations may taste of the ingesta. Bloating
Ruksha Udwartan (Dry medicated powder after eating. < By heat is a marked characteristic.
massage), The symptoms are < in the heat of the Sun. Nails
Heavy and non-nourishing diet/items like discoloured and deformed. Corns and callous
Honey, salad etc are advised. excrescences on the feet. Alternate diarrh�a
Physical exercises, mental work is also and constipation especially in aged persons.
recommended. 4. AURUM METALLICUM.
Samshodhana Chikitsa (Purificatory Fat patients with Arteriosclerosis and high blood
procedures): Panchakarma pressure. With fatty degeneration of heart.
1. Vaman (Therapeutic emesis), Patients with melancholy, hopelessness, profound
2. Virechan (Therapeutic purgation), depression, tendency to suicide and longing for
3. Lekhan vasti (Medicated enema) are advised death. Pain in heart region extending down left
for the management of Sthaulya. arm to fingers. Chilliness predominates ; coldness
4. Single drugs: Guduchi, Vidanga, Musta, of hands and feet, sometimes lasting all night.
Sunthi, Amla, Vaca, Daruharidra, Guggulu, etc. 5. CALCAREA CARBONICA.
5. Compound Formulations: Trikatu, Navak
Guggulu, Triphala Guggulu, Vidangadi This is the main remedy for reducing obesity. The
Churna,Takrarishta, Navayasa lauha, Arogya characteristic symptom is sweating on the
Vardhini Vati etc. forehead which wets the pillow when sleeping. It
6. LEADING HOMOEOPATHIC should be given in 200 potency with weekly
MEDICINES FOR TREAT OBESITY : repetition. This can be prescribed to obese
1. AMMONIUM CARB. children also. The patient�s hand is soft, warm,
and moist ; a boneless hand with clammy feet.
Great sensitiveness to cold, damp air. Dread of
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Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
bathing and water. Great weakness on ascending, obstinate constipation and flatulence. It is suitable
on walking and talking. to people with enlarged thyroid glands. Goitre has
been cured with it.
6. CALOTROPIS GIGANTEA.
This medicine is helpful in reducing the obesity 12. GRAPHITES.
without decreasing the weight i. e. flesh will be Obesity in females with delayed menstruation.
decreased, the muscles will become harder and Indicated for fair, fat, chilly, constipated people
firmer. Heat in stomach is a good guiding who have skin trouble. Helpful to those who have
symptom. lost desire for sex.
7. CAPSICUM. 13. KALI BICHROMICUM.
It is particularly suited to people who are weak of It is especially suited to fair-haired, fat persons,
lax fiber and who have little vital heat. The especially fat, chubby children ; fat, sluggish
digestion is poor and they suffer from myalgia people. Gastric symptoms supersede rheumatic
(aching and jerking of muscles). They have symptoms. Liability to take cold in the open air.
burning pains but hate the cold. Often indicated in Great debility, with desire to lie down.
old people who have exhausted their vitality. This
14. KALI CARBONICUM.
remedy is very suitable for children also. The
mental state shows home-sickness. > From heat is This remedy is especially good for older fat
the most important modality. people who are characterized by sweat, backache
and weakness. This remedy should be used
8. CARLSBAD. cautiously in Bright�s disease and
Its chief fame has been gained by its action on the Tuberculosis. This remedy is for dark haired
liver, and in the treatment of obesity and diabetes. persons of lax fibre and inclined to be fat.
Sensitiveness to cold air; great liability to take
15. PHYTOLACCA BERRY.
cold. Sweats more easily. > In open air ; on
motion. The breath smells offensive, the tongue is One of the effective weight and corpulence
white and feels furry. The patient is self-satisfied, reducing remedies.
very talkative and uncommondly good-humoured. TREATMENT OF Obesity in Allopathic:-
Discouraged and anxious about domestic duties.
Absent-minded ; heedless ; forgets names. List of drugs used to treat the medical condition
called Obesity
9. ESCULENTINE.
Generic and Trade Names of Drugs for
One of the great fat reducers. May be alternated Treatment of Obesity
with Phytoline. Both remedies should be used in
mother tincture. a. Atorvastatin
10. FERRUM METALLICUM. Atorvastatin is an HMG-CoA reductase inhibitor,
also known as "statin”, prescribed for
Obesity with an�mia, face puffy with pitting of hyperlipidemia.
flesh. This remedy is recommended to children
also. Delicate girls, fearfully constipated, with Trade Names :
low spirits. The pulse of the patient is full and Inovas -F | TG-Goal | Atamra F | Atorva -TG |
yielding. < From eating eggs. This remedy should Diplitor | Tonact TG | Axigrel AT | Lipikind -AM
be given carefully in h�morrhagic phthisis, as it | Eze AM | Zivast -AM
may aggravate. Rheumatic symptoms, especially
of left shoulder and deltoid. b. Benzphetamine
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Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
7
Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
FIG:-7 FIG:-8
Other than capsaicin, chilies have vitamin C, β Curry leaves, which are lavishly used for
carotene, and lutein which are well-known garnishing and flavoring dishes, are rich in
antioxidants. proteins, carbohydrates, fiber, minerals, carotene,
nicotinic acid, vitamins A and C, calcium and
A review paper published in 2012 looked into the
oxalic acid.
potential medicinal uses of capsaicinoid
compounds in relation to the regulation of weight. It is a rich source of biologically active
Capsaicinoids were found to increase energy compounds like koenigin, girinimbin, koenidine,
expenditure, lipid peroxidation, and also reduce triterpenoids etc.
the appetite. The leaves are traditionally used for its
In addition, it stimulates digestion and suppresses stomachic, tonic, antihelminithic, antidiabetic,
excess appetite caused by malabsorption of antidiarrheal, and carminative properties.
nutrients in the body.
Tomatoes
1. Make cayenne pepper tea by pouring a glass Tomato is an excellent natural medicine bursting
of hot water over cayenne pepper (start with one- with goodness that can help you in your battle
tenth of a teaspoon or just a dash of cayenne against obesity. Tomato is rich in vitamin A and
pepper and gradually increase its quantity to one C, potassium, phosphorus, magnesium, and iron
teaspoon). Squeeze the juice from half a lemon in that are required for normal activity of nerves and
it. Drink this tea regularly at least for a month. muscles.
2. Mix two tablespoons each of lemon juice in
10 ounces of water (one glass contains 8 ounces).
Stir in a dash of cayenne pepper and drink it.
3. Use cayenne pepper and other spices, such as
ginger, black pepper, and mustard seeds,
generously in your meal preparations.
4. Curry Leaves
Eating 10 fresh curry leaves daily in the morning
works as a great Ayurvedic remedy to deal with
obesity and diabetes caused by obesity.
FIG:-9
8
Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
Lycopene, the pigment responsible for the bright The members of Brassicaceae are a rich source of
red color of tomatoes, is very beneficial for the ascorbic acid, phenolic compounds, carotenoids
body. It works as a powerful antioxidant that and glucosinolates.
neutralizes damage by free radicals to cells in the Fennel
body. Other biological constituents of tomatoes Fennel seeds are believed to be useful in weight
include coumaric acid and chlorogenic acid. loss because of their diuretic properties. Fennel
seeds have that wonderful aroma around them,
They fight cancer by blocking powerful
which make them great for flavoring dishes.
carcinogens like nitrosamines. Tomatoes also
have anti-inflammatory and antithrombotic
properties. The bioavailabilty of lycopene and
other nutrients increases upon cooking and
processing.
Campari tomatoes which contain very high
amounts of lycopenes, were shown to lower lipid
levels in diet-induced obese zebrafish models in a
paper published in 2011.
Eat a couple of tomatoes every morning on an
empty stomach. Make sure you eat the peels and
seeds as well because they contain dietary fiber.
Tomatoes contain compounds that tend to alter
the levels of hormones that affect your appetite. FIG:-11
Furthermore, being rich in vitamins A, C, and K, The major compounds of fennel include essential
and magnesium, manganese, choline, folate, and oil, fatty acid, phenylpropanoids,
other nutrients, they are good for your health. monoterpenoids, sesquiterpenes, coumarins,
Also, they are packed with antioxidants that tannins, flavonoids etc.
protect against cancers.
The biological properties of fennel are attributed
Cabbage to its volatile and non-volatile compounds in it. It
Cabbage has been used as a remedy for weight is useful for the treatment of stomachic,
loss and obesity. Being a cruciferous vegetable, it analgesic, anti-inflammatory and antioxidant
contains phytochemicals that help improve the properties.
imbalance of estrogen metabolism. A diet of fennel seeds was shown to improve
weight loss and decrease leptin (a hormone linked
to body weight) concentration in obese animal
models in a study published in 2017. Diuretics
help you lose weight quickly by reducing water
retention. They do not cause long-term weight
loss though.
Conclusion
Pharmacological interventions in addition to
lifestyle changes (diet and physical activity) and
in some cases behavioural modifications are used
to promote weight loss. At present, only two
drugs are currently approved and available for the
FIG:-10 long-term treatment of obesity—orlistat and
Cabbage belongs to the Brassica genus, of which sibutramine. However, there are several drugs
kale, cauliflower, broccoli etc are also members. and combination drug therapies undergoing Phase
9
Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
III trials that may be approved in the next few 7. Kim MJ, Hwang JH, Ko HJ, Na HB, Kim JH.
years. Pharmacotherapies have demonstrated a Lemon detox diet reduced body fat, insulin
significant though modest decrease in weight resistance, and serum hs-CRP level without
compared to placebo over 1-2 years. hematological changes in overweight Korean
Unfortunately weight loss following women. Nutr Res. 2015;35(5):409-420.
pharmacological intervention is not sustained doi:10.1016/j.nutres.2015.04.001.
when therapy is discontinued with individuals 8. Budak NH, Kumbul Doguc D, Savas CM, et
regaining some or all of the weight that was al. Effects of Apple Cider Vinegars Produced
originally lost. There are several plants described with Different Techniques on Blood Lipids in
in ayurveda for weight management. But so far, High-Cholesterol-Fed Rats. J Agric Food
no systematic and well designed screening is Chem. 2011;59(12):6638-6644.
attempted to come up with an effective herbal doi:10.1021/jf104912h.
weight loss product. A better understanding in the 9. Budak NH, Aykin E, Seydim AC, Greene
existing evidence based science on herbs will AK, Guzel-Seydim ZB. Functional Properties
further guide a qualitative research in obesity of Vinegar. J Food Sci. 2014;79(5):R757-
management that will attract the end users by the R764. doi:10.1111/1750-3841.12434.
effective benefits. True randomized, double 10. Surjushe A, Vasani R, Saple DG. Aloe vera: a
blinded, placebo-controlled clinical trials using short review. Indian J Dermatol.
herbal products will demonstrate their poten-tial 2008;53(4):163-166. doi:10.4103/0019-
benefits. Significant weight loss after placebo 5154.44785.
sub-traction along with known mechanism of 11. Misawa E, Tanaka M, Nomaguchi K, et al.
action are re-quired in order to generate Administration of phytosterols isolated from
conviction amongst users as effective agent for Aloe vera gel reduce visceral fat mass and
weight management. improve hyperglycemia in Zucker diabetic
fatty (ZDF) rats. Obes Res Clin Pract.
REFERENCE:
2008;2(4):I-II.
1. Overweight, Obesity and Mortality Charaka doi:10.1016/j.orcp.2008.06.002.
Samhita (Agnivesh tantra), Sutra Sansthana 12. MISAWA E, TANAKA M, NABESHIMA K,
P.V. Sharma (2005). Dravyaguna Vijnana: et al. Administration of Dried Aloe vera Gel
Vol. 1 (Basic Concepts). Powder Reduced Body Fat Mass in Diet-
2. Medication is to be taken strictly under Induced Obesity (DIO) Rats. J Nutr Sci
supervision of Registered Ayurvedic Vitaminol (Tokyo). 2012;58(3):195-201.
physician. doi:10.3177/jnsv.58.195.
3. Visit National Institutes/ CCRAS Research 13. Grove KA, Sae-Tan S, Kennett MJ, Lambert
Centres for necessary JD. (−)−Epigallocatechin-3-gallate Inhibits
consultation.(www.ccras.nic.in) Pancreatic Lipase and Reduces Body Weight
4. file:///D:/my%20project/Best%20Ayurvedic% Gain in High Fat-Fed Obese Mice. Obesity.
20Medicine%20for%20Weight%20Loss%20 2012;20(11):2311-2313.
%E2%80%93%20Safe%20&%20Effective% doi:10.1038/oby.2011.139.
20Treatment.htm 14. Hursel R, Viechtbauer W, Westerterp-
5. https://www.medindia.net/drugs/medical- Plantenga MS. The effects of green tea on
condition/obesity.htm weight loss and weight maintenance: a meta-
6. Magkos F, Fraterrigo G, Yoshino J, et al. analysis. Int J Obes. 2009;33(9):956-961.
Effects of Moderate and Subsequent doi:10.1038/ijo.2009.135.
Progressive Weight Loss on Metabolic 15. Whiting S, Derbyshire E, Tiwari BK.
Function and Adipose Tissue Biology in Capsaicinoids and capsinoids. A potential role
Humans with Obesity. Cell Metab. for weight management? A systematic review
2016;23(4):591-601. of the evidence. Appetite. 2012;59(2):341-
doi:10.1016/j.cmet.2016.02.005. 348. doi:10.1016/J.APPET.2012.05.015.
10
Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
16. Ahuja KD, Robertson IK, Geraghty DP, Ball European Heart Journal, vol. 28, no. 23, pp.
MJ. Effects of chili consumption on 2915–2923, 2007.
postprandial glucose, insulin, and energy 25. GLG Expert Contributor. New Meridia
metabolism. Am J Clin Nutr. 2006;84(1):63- SCOUT trial has major implications for
69. doi:10.1093/ajcn/84.1.63. obesity drug development, 2009,
17. Birari R, Javia V, Bhutani KK. Antiobesity http://www.glgroup.com/News/New-Meridia-
and lipid lowering effects of Murraya koenigii SCOUT-Trialhas- Major-Implications-for-
(L.) Spreng leaves extracts and mahanimbine Obesity-Drug-Development- 45006.html.
on high fat diet induced obese rats. 26. FDA Drug Safety Communication: Follow-
Fitoterapia. 2010;81(8):1129-1133. Up to the November 2009 Early
doi:10.1016/j.fitote.2010.07.013. Communication about an Ongoing Safety
18. Tainaka T, Shimada Y, Kuroyanagi J, et al. Review of Sibutramine, Marketed as
Transcriptome analysis of anti-fatty liver Meridia,
action by Campari tomato using a zebrafish 2010,http://www.fda.gov/Drugs/DrugSafety/P
diet-induced obesity model. Nutr Metab ostmarketDrug-Safety Information for
(Lond). 2011;8(1):88. doi:10.1186/1743- PatientsandProviders/DrugSafetyInformationf
7075-8-88. orHeathcareProfessionals/ ucm198206.htm.
19. Sankhari JM, Thounaojam MC, Jadeja RN, 27. N. Singer and A. Pollack, Heart Patients
Devkar R V, Ramachandran A V. Warned Against Using Meridia, an Anti-
Anthocyanin-rich red cabbage (Brassica Obesity Drug. The New York Times, 2010,
oleracea L.) extract attenuates cardiac and http://www.nytimes.com/2010/01/23/business
hepatic oxidative stress in rats fed an / 23diet.html.
atherogenic diet. J Sci Food Agric. 28. M. Harrison-Woolrych, J. Ashton, and P.
2012;92(8):1688-1693. doi:10.1002/jsfa.5532. Herbison, “Fatal and non-fatal cardiovascular
20. Nejatbakhsh R, Riyahi S, Farrokhi A, et al. events in a general population prescribed
Ameliorating effects of fennel and cumin sibutramine in New Zealand: a prospective
extracts on sperm quality and spermatogenic cohort study,” Drug Safety, vol. 33, no. 7, pp.
cells apoptosis by inducing weight loss and 605–613, 2010.
reducing leptin concentration in diet-induced 29. A. Astrup, “Drug management of obesity—
obese rats. Andrologia. 2017;49(8):e12748. efficacy versus safety,” The New England
doi:10.1111/and.12748. Journal of Medicine, vol. 363, no. 3, pp. 288–
21. https://www.top10homeremedies.com/home- 290, 2010.
remedies/home-remedies-obesity.html. 30. K. Cahill and M. Ussher, “Cannabinoid type 1
22. A. M. Sharma, I. D. Caterson, W. Coutinho et receptor antagonists (rimonabant) for
al., “Blood pressure changes associated with smoking cessation,” Cochrane Database of
sibutramine and weight management—an Systematic Reviews, no. 4, Article ID
analysis from the 6-week lead-in period of the CD005353, 2007.
sibutramine cardiovascular outcomes trial 31. L. Van Gaal, X. Pi-Sunyer, J. P. Despr´es, C.
(SCOUT),” Diabetes, Obesity McCarthy, and A. Scheen, “Efficacy and
andMetabolism, vol. 11, no. 3, pp. 239–250, safety of rimonabant for improvement of
2009. multiple cardiometabolic risk factors in
23. S. Von Haehling,M. Lainscak, and S. D. overweight/obese patients: pooled 1-year data
Anker, “Sibutramine in cardiovascular from the Rimonabant in Obesity (RIO)
disease: is SCOUT the new STORM on the program,” Diabetes care, vol. 31, supplement
horizon?” European Heart Journal, vol. 28, 2, pp. S229–240, 2008.
no. 23, pp. 2830–2831, 2007. 32. K. Fujioka, C. Apovian, and J. Hill, The
24. C. Torp-Pedersen, I. Caterson, W. Coutinho Evolution of Obesity Therapies: New
et al., “Cardiovascular responses to weight Applications for Existing Drugs.
management and sibutramine in high-risk MedscapeCME Diabetes Endocrinology,
subjects: an analysis from the SCOUT trial,”
11
Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
12
Richa Tibrewal et al., International Journal of Medical and Biomedical Studies
50. C. Addy, H. Wright, K. Van Laere et al., 52. “Worldwide Obesity Trends—Globesity,”
“The acyclic CB1R inverse agonist taranabant http://www.annecollins.com/obesity/causes-
mediates weight loss by increasing energy of-obesity.htm
expenditure and decreasing caloric intake,” 53. Centre for Public Health Excellence at NICE
Cell Metabolism, vol. 7, no. 1, pp. 68–78, (UK), Na-tional Collaborating Centre for
2008. Primary Care (UK), “Obesity: The
51. World Health Organization, “Obesity. Prevention, Identification, Assessment and
Preventing and Managing the Global Management of Overweight and Obesity in
Epidemic, Report of a WHO Con- sultation Adults and Children,” National Institute for
(WHO Technical Report Series 894),” WHO, Health and Clinical Ex-cellence (UK) (NICE
2000. Clinical Guidelines, No. 43), 2006.
http://www.who.int/nutrition/publications/obe http://www.ncbi.nlm.nih.gov/books/NBK636
sity/WHO_TRS_894/en/ 96/
13