Creatine Phosphokinase

Creative Enzymes

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Creatine kinase (CK, EC 2.7.3.2), also known as creatine phosphokinase, is an enzyme
catalyzing the phosphorylation of creatine. CK utilizes adenosine triphosphate (ATP) to
reversibly produce phosphocreatine (PCr) and adenosine diphosphate (ADP). Therefore,
ATP can be regenerated from PCr and ADP. CK is expressed by various tissues and cell
types, mainly found in skeletal muscle, cardiac muscle, and the brain, bladder, stomach,
and colon. The ubiquity of CK in many tissues causes a poor specificity. In tissues and
cells that consume ATP rapidly, especially skeletal muscle, PCr functions as an energy
reservoir for the rapid buffering and regeneration of ATP in situ, as well as for
intracellular energy transport by the PCr shuttle or circuit. CK is of great importance in
skeletal muscle energy metabolism. CK concentration could be elevated by muscle
necrosis or disease. Therefore, CK is clinically assayed as a marker of damage of CK-
rich tissue and may also be measured to evaluate myopathy.
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