JAQUELYN McCANDLESS, M.D.

21800 Marylee St. #48

Woodland Hills, CA 91367
Phone 818-716-0565, Fax 818-337-7338

Mr. Bart A. Starr November 18, 2003

Shook, Hardy & Bacon L.L.P.
One Kansas City Place, 1200 Main Street
Kansas City, Missouri 64 105-2118

Dear Mr. Starr:

I have received your letter re: Dr. William Shaw’s U.S. Patent No. 5,686,311. You are
apparently under the impression that I perform lab tests; I do not. I am a physician with a
sole practitioner private practice that includes autistic children, and am currently in the
process of letting my practice go and entering full time into teaching, writing, and
consultation. I am independent, with no ties to any laboratory or pharmaceutical firm.

Dr. Shaw is recognized in the autistic community as the first to describe elevated urinary
yeast metabolites in autistic children as evidenced through his organic acid test. His
patent has to do with using this test to diagnose autism. I have never used this test as a
method of diagnosing autism, as every child who has ever come to me as a specialist
has had the diagnosis made already by their primary pediatrician. I might add
diagnosis of autism is never made on the basis of an organic acid test, as this is not
used in any way to ascertain whether a child is autistic or not.

The other part of his patent has to do with the treatment of autistic patients by the use of
antifungals to treat certain symptoms of autism, indicating mycostatin as the preferred
antifungal drug. I had already been using anti-fungals as treatment for yeast problems in
a variety of patients over the years before I started to work with autistics in 1997 or heard
about Shaw’s work. Yeast though common is not pathognomonic for autism; people
without autism have yeast and are treated with antifungal drugs available prior to
Shaw’s patent. Any physician has the right to use a legal drug for any purpose he
or she deems appropriate. I might add that I have not recommended mycostatin
for years, as I seldom found it effective in my population.

In summary, though I appreciate Dr. Shaw’s pioneering work in this area and feel the
organic acid test is useful as one guide for the multiple treatments of autism, I see no
infringement of his patent in my work with autistic children and no need for a license
agreement under his patent such as you are proposing.

Sincerely,
Jaquelyn McCandless, M.D.
Jaquelyn McCandless, M.D.