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  • Yeast Beta-Glucan (Updated)

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    Ahmad Raza
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    yeast beta-glucan (updated)(1)

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    49 views12 pages

    Yeast Beta-Glucan (Updated)

    Uploaded by

    Ahmad Raza

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 12
    = SHREAR -0727-008 YEAST BETA GLUCAN ft © ® s Kon www.txyglucan.com BE B-BRHAIM Yeast Beta Glucan Introdction An example ofa 6-13:6:1/6Linkage 1H EESR- RS SET HA HDD SR, HEGRE S. 1 SST , EHIB-138 ADM , B-LORAEETIAL, HORT RE A RIDIN . SAEED. Yeast Beta Glucan is immune polysaccharides in cell wall of yeast. Its produced by modern bio-engineering technology via autolysis .enzymolysis, cell wall broken ,refining and spray drying . The Beta- 4,3(D)-glucan with Beta- 1,6-glucan linkage extracted from yeast cell wall has been shown to act as a potent non-specific immune- etal. O nina 6 nina ‘Stimulate the macrophage of the immune system Anti-tumor O aeane © nae Inhibit the free radical in body Anti-radiation © sess O timex Modulate the allergic immune of the physical condition Anti-infection O xemieme © Bem Improve intestinal function Regulate blood lipid (FRR Action Principle ORB ROR Oral B-glucan A sees wipare 80 ave® ° "o. qo * . @) © @m att: @ EMER op FAD Kate al Activated Prog, kine fh eee macrophage ar wi mew ER Beam Intestinal “| “intestinal Activates: lumen lymphoid Nk cells tissue Other macrophages iia Lae reel Intestinal Beells epithelium HSEABE=B4 (HB) Structure of Yeast Cell Wall — BAR Protein — RM B-Glucan — [Ki Cell Membrane BSGRRAUS SOMA ASOA , MERA. ptt Ai, NKRIOS , FHEARAGRERM , KRERRD OA MBAIF(IL-1, IL-6) S , LUBA. I>, SRA ARRAN AE , MEAL RRIETNAE , HOLA. Yeast beta-glucans stimulate specific activation of immune cells such as macrophages, granulocytes, NK cells, and promote immune cascade to secretes cytokines (IL-1, IL-6) to enhance the immune system. In addition, yeast beta-glucan has a function like dietary fiber , which can improve intestinal function and reduce blood lipids and cholesterol Bh) RIS & Application Trails 55) B-AO MEY BL AAC A Effects of the beta glucan on the antibody levels of the rmice's IgM. REGRET: MOSM M MARRS EIR. The result shows that beta glucan can increase antibody levels of the mice’s IgM to promote humoral immunity RARE : RARE P ORME Source from : Guangdong Center for Disease Control and Prevention report BES B-FORE SRY I BAN KABUTO EOE, Efects of the beta glucan on the activity of the mice's NKeell, BRAT: BAOMNKAMELMA RM, Be BAA IANKERIOS TEES The result shows that beta glucan can strength the activity of the NK cell A 4% 89 2B Application In Humans HE: RRARKBER AMM ER TEAM SAR (MEMES) LLRI il “BAT be. Intestinal : key factors of immune system ‘The epithelium of intestinalis an ecosystem consisting of a great number of immune cell (lymphocyte) + wich prevents he “invader” damaging ourhealth me - ite aa OO Ee rt Eessmannann Fighting withthe pathogenic HSRwRRA LER PAREN, MOBMRMNMEM Se, KMeMER SRARERAMESR ARF, MANKSR, THR, 0% RMOSRIE. Yeast beta glucan can active Macrophage As biological defense modifier (BDM), which acts through the activation of macrophage yeast beta-glucan increase Phagocytosis and product cytokine witch activate NK cel, cell and Beell. see aaa Sx a Activity Pathogenic SAO AR NSNMMIOTS IA (ES B85 AT ‘Activated cellcan easily respond ang kill the pathogenic WG PRAM: TRUS : DAE ART, RA : REPORTED PRASAD , ee Lorn. TRIE: AFKMARRAD , RSMMC EA, S RABHLIMEME , AKRMUMI2IGINSRS (SomBt mse, INFHIY AM AwSS HSH), HAMA, RSOVMCAMSM RATS) , SAR TAMRA—TA . SAGR2OMg AI. BR: RATEEME OE B4 , Lee AEN (34% ; CRE RINNE IA5%, RG AORORE ARREARRED , RAMA EORES Pe EOF, BAREF : SH (BRB) RE Source from : wit 2B Average Symptom Days per Subject ee =e 9 z Ss c z os : 3 : i : : maemo tie Yeast Bete-sucan ‘Saluble FROM ‘Yeast Beta-glucan (dispersive) sun Placebo Clinical Performance Research Institution: Health and Human Performance Lab at the University of Houston Subject: Valisation of yeast glucan in the general environment can improve human immunity, reduce the risk of upper respiratory tract infection. Research Method: Due to long time exposed outdoors, usually within one week after attending the marathon . runners can be more respiratory infected . selected 182 marathoners (double-blinded study included 96 men and 86 women, with an average age of 34, ‘and an average finish time four hours ), divided into three ‘groups, respectively taking yeast beta-glican insoluble , yeast beta-glucan soluble and placebo for 4 weeks, 250 mg per person per day. Result: Taking 4 weeks of insoluble yeast beta- glucan can reduce the tisk of URTI by 34%%;soluble yeast bela-glucan reduced by 45%Yeast beta-glucan can effectively enhance human immunity, help us against exotic harmful substances, and reduce the risk of URTI. ee Hit Ge SRS BABE 2 Why is TXY yeast beta-glcuan? an 1 wexners ! Pure cultured baker's yeast ASRESPMREART HOSS , BHDFHS1 kDa, S WHRRALS , Nihil R BMA, ee: B A, BRE, eR, WR, He. O RUFSKE : RHHRRRASNRANS Aes) RERD , PRRBRIIMRAK O BSNRBLEREAR : RASA TS EM SEE BRMODRMRAR ROE. ° ANGER : BARBY , RRS: TXY 's yeast beta-glucan derived from baker's yeast, saccharomyces cerevrsrae , weight-average molecular weight is 81 KDa . During the complex purification process, other cell components like protein, lipids, nucleic acids, minerals and mannans are removed to a large extent. @ Baker's yeast, Saccharomyces cerevisiae , pure cultured in sugarcane molasses , the extract products have less impurity , nice appearance and better odor. © Unique fermentation process ensure the thickness of the yeast cell wall , leading to high content and structural integrity © Stable quality: TXY fermentation base ensure stable quality aa 2Reneep aE. wR ! The higher the glucan purity, The better immune effect. BFSB-1,3-1,6 RRMA BIBS , (PARAS SESH ( PAMPs ) EER LAS ASABE (dectin-1, CR3, Sc, Laccer, TLR) , MAB, 5 © AZAANE SMS ( S20 RM) , LER SMES , REMRTE. O KXENRRE. SABRD . Ki, HBRHBRS RESRMDF Be OESS MRR RA RA , UR AAR. © RAREHORARARMMMLAA, SEAR BEAR LAD AY OR AS T BEB -1,3-1,6 BR HB AY Se N9 , URRIASSMLLL, © SHRM GARTER RESR (USP) MR: KSRPGARMS SM Bimik , HBP-1,3-16 ORB, BHR. A RRBSELSS Hh AML EARB-13-16 SR SPR , GRRBSUSPAHHAMERAR—H. © B-1, 6S MAB-1,3-1,688 18%EG , WEIB-1,3885 8-16 RSA. Yeast B-glucan goes into the intestine as a PAMPS , it was recognized by variety of receptors on the surface of intestinal cells, such as Dectin-1, CR3, So, Laccer, TLR B-Glucans trigger immune responses after identified. © Not purified yeast cell wall, 20% content beta-glucan , would faild bind to the receptor and had no obvious immune effect. @ Low purity beta-Giucan contais large amount impurity of ash, fat, protein and mannose and other polysaccharide components, which seriously reduce the B1,3/1,6 Glucan receptor recognition. © TXY bota-glucan experienced mild processing removing large impurities and remaining structural iniegity of beta 4,9/1,6 glucan . TXY Bglucan content is more than 85%. © Various of method and instruments of detection The content and structure of TXY have been verified by HPLC,, H-NMR, GC-MS, and up to USP standard quality © Thorelative porcentage of (1.6) linked glucans 18% forthe total linkages. wad nenoxieae ! Evaluation by authoritative organization OGRE , AGREES ARERAU PR : © DeRAARSMRNKAROE. Agrnemreree O NKFEFRGRSMDRPRR, © Mie. O BHRASE , ABR, ARAA. OF ai 2S 25 CE th HO Report from Guangdong provincial cent for disease control and prevention Experiment of mice confirmed that TXY yeast beta glucan has the characteristics as below © Signincantly enhance humoral immunity and nk cell activity. @ The auxiliary treatment effect to the chemical ver injury. © Tomur inhibition, High dose no poison , no mutation and no saltation EE eR BRB Bt BGS-MRMAM QB/T4572-2013 88.6 % men B5009.5.2010 2.77 _—g/100g ans 68/T5009.6-2003. 2.1 g/l00g Item Standard Result Unit B-Glucan Qe/14572-2013 88.6% Protein 6B5009.5-2010 2.77 __—g/100g Fat 68/7 5009.6-2003. 2.1 5/100 AMPD: PEARRNALARAERERRRRERAPD Testing Organization: Export - Import Inspection & Quarantine Bureau of .R.C. Bins ig room SAU spt a USP can om esse XY fan) RAPD: RATALAFE ORD ROMER: WAH MAbeta RM 1-6 FATS F 1-38 SHB 18%. |i NMR Spectroscopy Testing Organization: UGA TESTING SERVICE According to the integration results, the relative area of the resonance corresponding to the signal of 1,6-1inked beta glucan with respect to the 1H signal of 1,3-linked beta glucan is 18% for the test sample. BRIAR MAR Enzymatic detection result UVRESMUMERASRM , KSGYSS- MRAM RT Table 2 Percentage of beta glucan as Glucose in the standard and test beta glucan Glemgiml in Gc mg/ml in total Sample sample solution, % Glucose final 0.845ul 26m USP Glucan 0.739 12.49 78.05 TXY Glucan 0.738 12.47 77.79 AMMA HRAME Application And Usage For Food tt ne SMEFA(mg) S750 | Ree 250 auean Rea 250 ERM G/SF (BR Ses Mee S) Rea 250 SEG G/F (BR BH MER S) Rawal 250 u/s Ree 125-250 +RARES St (GR Gig set eS) Rew 250 +R SE (BR OHH MAE RS) Ree 125-250 Re 125-250 ABT 125-250 Rea 125-250 RBs 125-250 a A Ree 125-250 ose AEwTE 125-250 Sal ABD 125-250 BORER Ree 125-250 aR Rea 125-250 ce aee 125-250 TxY TAY Servint Applications ora (cairo Recommended Ad FOOD Yogurt disp or sol 250 After fermentation Sports & Nutrition Bars disp or sol 250 Grable wirinoe (color favor vit tc) leal Replacements disp or sol 280 Preblend w/minors (colo¢ flavor, vit. etc. Cereals & Granola Bars disp or sol 250 Post extrusion/Dry blend w/minors ks disp or sol 125-250 Erablend wiminore (calor, yor vi sc Baked Goods disp or sol 250 Preblend wiminors (color, flavor, vit. ete. BEVERAGES Juices & Smoothies disp or sol 125-250 Enhanced Waters solu ble 125-250 Sports & Energy Drinks disp or sol 125-280, Natritional ges disp of sol 125-250, Milk & Dairy Products disp or sol 125-250, Before pasteurization / UHT sterilization ‘SUPPLEMENTS | Capsules & Tablets dispersible 125-250 Blend wiexcilents & minors prior io filing or tb Gummies & Chewables disp or sol 125-250, Preblend w/ minors (color, flavor ic.) Powdered Mixes: dispersible 125-250, Preblend w/ minors (color, flavor tc) Shots disp or sol 125-280, Betore posfeurization / UHT sterilization Effervescents disp or sol 125-250, Preblend w/ minors (color, flavor, vit. etc.) Soft Gels dispersible 125-250 RRSi

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