Department of Education

Region XI
Division of DAVAO DE ORO
PANTUKAN NATIONAL HIGH SCHOOL
Pantukan, Davao De Oro

Sci-Life Ethical Genetic Issues (Debate 2019)

A Performance Task in Applied Chemistry on BIO-

Molecules
(Issues Related in Genetic Engineering)

Grade 9-Einstein

3rd Quarter

S.Y 2019-2020

SHARON ROSE C. SAPINE

Subject Teacher

December 6, 2019
 INTRODUCTION

ACTIVITY DESIGN

PROGRAM

MECHANICS

DEBATE QUESTIONS

SIGNALS

RUBRICS

PARTICIPANTS

COMMITTEE

DOCUMENTARY
 INTRODUCTION

Why is considering hereditary qualities significant?

Later on, specialists and researchers would like to utilize our hereditary data to

analyze, treat, avert and fix numerous diseases. Genes are directions, which

advise your body how to make every one of the proteins it needs to endure and

develop. By distinguishing every one of these proteins, researchers would like to

all the more likely see how your body functions, and what's going on when it

doesn't work appropriately. They trust this information will in the end lead to

progressively powerful medications and medicines.

Advances in hereditary research guarantee extraordinary walks in the conclusion

and treatment of numerous youth sicknesses. In any case, rising hereditary

innovation frequently empowers testing and screening before the improvement of

authoritative treatment or preventive measures. In these conditions, cautious

thought must be given to testing and screening of kids to guarantee that

utilization of this innovation advances the wellbeing of the kid. This

announcement audits contemplations for the utilization of hereditary innovation

for infant screening, transporter testing, and testing for helplessness to late-

beginning conditions. Suggestions are made advancing educated cooperation by

guardians for infant screening and restricted utilization of bearer testing and

testing for late-beginning conditions in the pediatric populace. Extra research and
 training in this creating zone of medication are empowered. Over the previous

decade, numerous moral, legitimate, and social issues (ELSI) related with

hereditary testing and researches have been raised. For hereditary testing to be

utilized securely and properly, these issues ought to be talked about with patients

so they know about dangers and advantages.

What is genetic engineering?

Genetic engineering refers to the direct manipulation of DNA to alter an organism’s

characteristics (phenotype) in a particular way.

What is genetic engineering?

 Genetic engineering, sometimes called genetic modification, is the process of

altering the DNA? in an organism’s genome?.

 This may mean changing one base pair? (A-T or C-G), deleting a whole region of

DNA, or introducing an additional copy of a gene?.

 It may also mean extracting DNA from another organism’s genome and

combining it with the DNA of that individual.

 Genetic engineering is used by scientists to enhance or modify the

characteristics of an individual organism.

 Genetic engineering can be applied to any organism, from a virus? to a sheep.

 For example, genetic engineering can be used to produce plants that have a

higher nutritional value or can tolerate exposure to herbicides.

How does genetic engineering work?

To help explain the process of genetic engineering we have taken the example of

insulin, a protein? that helps regulate the sugar levels in our blood.
  Normally insulin? is produced in the pancreas?, but in people with type

1 diabetes? there is a problem with insulin production.

 People with diabetes therefore have to inject insulin to control their blood sugar

levels.

 Genetic engineering has been used to produce a type of insulin, very similar to

our own, from yeast and bacteria? like E. coli?.

 This genetically modified insulin, ‘Humulin’ was licensed for human use in 1982.

The genetic engineering process

1. A small piece of circular DNA called a plasmid? is extracted from the bacteria or

yeast cell.

2. A small section is then cut out of the circular plasmid by restriction

enzymes, ‘molecular scissors’.

3. The gene for human insulin is inserted into the gap in the plasmid. This plasmid

is now genetically modified.

4. The genetically modified plasmid is introduced into a new bacteria or yeast cell.

5. This cell then divides rapidly and starts making insulin.

6. To create large amounts of the cells, the genetically modified bacteria or

yeast are grown in large fermentation vessels that contain all the nutrients they

need. The more the cells divide, the more insulin is produced.
 7. When fermentation is complete, the mixture is filtered to release the insulin.

8. The insulin is then purified and packaged

into bottles and insulin pens for distribution

to patients with diabetes.

An illustration showing how genetic modification is used to produce insulin in bacteria.

Image credit: Genome Research Limited

What else is genetic engineering used for?

 The first genetically modified organism to be created was a bacterium, in 1973.

 In 1974, the same techniques were applied to mice.

 In 1994 the first genetically modified foods were made available.

 Genetic engineering has a number of useful applications, including scientific

research, agriculture and technology.

 In plants, genetic engineering has been applied to improve the resilience,

nutritional value and growth rate of crops such as potatoes, tomatoes and rice.

 In animals it has been used to develop sheep that produce a therapeutic protein

in their milk that can be used to treat cystic fibrosis, or worms that glow in the

dark to allow scientists to learn more about diseases such as Alzheimer’s?.

Alzheimer’s disease and the worm

 The nematode worm, C. elegans, only has around 300 cells in its entire nervous

system, making it a very simple model for studying Alzheimer’s disease.

 Also, due to the fact the worm is nearly transparent, when their nerve cells are

labelled with green fluorescent protein (GFP), it is possible to watch the location

and activity of various structures and proteins under the microscope.

 The genetic material of C. elegans can easily be genetically modified to make the

worm produce specific proteins the researchers want to study.

 In humans, the APP gene codes for a protein associated with the amyloid

plaques that are characteristic of people with Alzheimer’s disease.

 So, to study Alzheimer’s, the researchers genetically engineered the nerve cells

of the worm to contain the APP gene, effectively giving it Alzheimer’s.

 By tagging the APP protein produced in the worm with green fluorescent protein

it was possible to see that all the cells that made contact with APP died as the

worm got older.

 The researchers were then able to monitor the progression of Alzheimer’s

disease in the worm and go on to apply their findings to understanding the role of

APP in humans with Alzheimer’s disease.

ACTIVITY DESIGN

Republic of the Philippines

Department of Education

Region XI

Division of Davao De Oro

PANTUKAN NATIONAL HIGH SCHOOL

“The Home of Character and Excellence”

I. TITLE

• Genetic Debate

II. DATE AND VENUE

• Grade 9 Einstein Classroom

• December 6, 2019

III. PARTICIPANTS

• Grade 9 Einstein Students

IV. OBJECTIVES

• This debate is aimed to evaluate the significance of the idea of Genetic

Engineering.

• Debaters should understand how to be able to share their opinions.

• Students should become more aware of global and core issues about Genetic
Engineering

• Students should gain critical thinking skills.

• Have a basic understanding of the future of the global economy in using
genetically modified organisms.

V. RATIONALE

• The rationale behind the package is that students will have opportunities to
enhance their presentation, interpretation, argumentation, collaboration, critical
thinking and information skills.

VI. BUDGETARY REQUIREMENTS

• NONE

VII. SOURCE OF FUNDS

• NONE

Prepared By:

KRYSHNA LEIGH D. UNGGOY

Applied Chemistry- P.I.O

PROGRAM

REANNAH HILAMON
PRAYER
MODERATOR
INTRODUCTION
ALDREAH DINAGAT
OPENING REMARKS
JOHN PAUL A. MIGULLAS

READING OF OBJECTIVES/MECHANICS/RUBRICS

INTRODUCTION OF PARTICIPANTS/JUDGE MODERATOR

DEBATE

PROCLAMATION/RESULTS
KRYSHNA UNGGOY

CLOSING REMARK SHARON ROSE SAPINE

Jeane Leonado

Honey Bee Canazares

Kristhea Galing

Reannah Hilamon

Kryshna Unggoy

Christian Compasion
ACTUAL FRAME

FRONT BACK
 Sci-LIFE Genetics Debate 2019
Programme
REANNAH HILAMON
PRAYER
MODERATOR
INTRODUCTION
ALDREAH DINAGAT
OPENING REMARKS
JOHN PAUL A. MIGULLAS
READING OF
OBJECTIVES/MECHANICS/RUBRICS

INTRODUCTION OF MODERATOR
PARTICIPANTS/JUDGE

DEBATE

PROCLAMATION/RESULTS KRYSHNA UNGGOY

CLOSING REMARK SHARON ROSE SAPINE

Jeane Leonado
Jeane Leonado
Honey Bee Canazares
Honey Bee Canazares
Kristhea Galing
Kristhea Galing
Reannah Hilamon
Reannah Hilamon
 Special Thanks
THE COMMITTEE John Paul A. Migullas
Aldreah Mahrie Dinagat
Jeane Leonado
Honey Bee Canazares
Kristhea Galing
Reannah Hilamon
Kryshna Unggoy
Christian Compasion
Jade Tormis
SpecialAiraThanks
SUBJECT TEACHER Aguilar
THE COMMITTEE Sharon Rose Sapine
John Paul A. Migullas
Aldreah Mahrie Dinagat
Jeane Leonado

Sci-LIFE Genetics
Honey Bee Canazares

Debate
Kristhea Galing
Reannah Hilamon
Kryshna Unggoy
Christian Compasion
Adviser 2019 Jade Tormis
Sharon Rose Sapine
6 December 2019
Friday, 10 am - 12 pm
Pantukan National High School

Sci-LIFE Genetics
MECHANICS

There are questions that can be answered yes or no. Automatically the Disagree is No

and group Agree yes.

For the discussion each party will be given 30 sec. To share their ideas

There are two rounds. In each round you are given 1 min. To explain your side. The

first round is the sharing of ideas. The second round us the rebuttal.

For the rebuttal, the argument must connect to the counter attack of the other side.

No foul words. For each foul words there will be corresponding minus points

The debaters are given a chance to explain their side in Visaya, Tagalog or in English.

There are 3 levels for the question. Easy, Average and Difficult. Question and level of

difficulty will be drawn by our judges for the fairness of each party
DEBATE QUESTIONS

LEVELS

 EASY

 AVERAGE

 DIFFICULT

TOPICS

 HUMAN RESEARCH

 CLONING

 GENE THERAPY

 POLICY

 ENVIRONMENT

 CRISPR

 GMO

 DESIGNER BABIES

 FOOD GENETIC ENGINEERING

EASY

GENETIC ENGINEERING

Should animals be used in research?

CLONING I

Just as scientists have cloned other mammals such as sheep and cats, the cloning of

humans should be explored further?

CRISPR

Must we modify animals or an organism in order stay competitive?

GENE THERAPY I

Should people be allowed to use gene therapy to enhance basic human traits such

as height, intelligence, or athletic ability?

HUMAN RESEARCH

Do you think that research on human pre- embryos should be allowed?

AVERAGE

FOOD

Genetically modified foods are thought to be safe to eat; their impact on the

environment may be fully known.

CLONING

Cloning sounds pretty cool, but are there any practical reasons why it should be

done?

What benefits may arise from cloning animals? What about humans? Should the U.S.

fund research into cloning?

GMO I

The use of genetically modified organisms is valuable and safe method of addressing

the world’s agricultural needs.

ENVIRONMENT

Have genetically engineered crops reduced insecticide applications?

POLICY

Do you think that research on human pre- embryos should be allowed? Should fetal

tissue be used to treat disease?

DIFFICULT

DESIGNER BABIES

Should parents be able to choose the sex of their child? What is the line that we, as a

society, "should not" cross? Is screening for disease appropriate?

GENE THERAPY III

Gene therapy is under study to determine whether it could be used to treat disease.

Current research is evaluating the safety of gene therapy; future studies will test

whether it is an effective treatment option.

GENE THERAPY

Scientists believe that human embryonic stem cells hold the key to treatments and

cures for a wide variety of diseases. But others are fundamentally opposed, on moral
grounds, to the use of human embryos for scientific purposes. Should the U.S. fund

research that involves human embryos?

GMO

Genetically modified foods boast a wide range of benefits, but

are they safe for human consumption? How might they affect the environment?

Should we as a society condone the genetic modification for the future?

GENE THERAPY II

Rats have been used by scientist to develop a nasal spray gene therapy for cystic

fibrosis. Mice can manufacture some human proteins in their blood. Dogs were

important in developing treatments for hemophilia and bone marrow transplants would

not be possible without earlier work done with dogs. Many people object to the use of

mammals in experiments. Do you feel that animal models of human genetic disease

are necessary. Should treatments be allowed on laboratory mammals before

attempting the treatment on humans?

SIGNALS

RED FLAG – STOP GREEN FLAG - GO

10 SECONDS LEFT
PARTICIPANTS

JOHN PAUL A. MIGULLAS – ORGANIZER, MODERATOR

ALDREAH MAHRIE DINAGAT – FOUL WORDS SUPERVISOR

JADE TORMIS- FOUL WORDS

HONEY BEE CAÑAZARES- FOUL WORDS

JEANE LEONADO - MODERATOR

KRISTHEA GALING- TIME KEEPER

REANNAH HILAMON- TIME KEEPER

CHRISTIAN COMPASION- FLAG SIGNALS

AIRA AGUILAR- CROWD CONTROL

KRYSHNA UNGGOY- CERTIFICATES

COMMITTEE

JOHN PAUL A. MIGULLAS

ALDREAH MAHRIE DINAGAT

JEANE LEONADO

HONEY BEE CAÑAZARES

KRISTHEA GALING

REANNAH HILAMON

KRYSHNA UNGGOY

CHRISTIAN COMPASION

JADE TORMIS

AIRA AGUILAR
DOCUMENTARY
REFERENCES

http://whoami.sciencemuseum.org.uk/whoami/findoutmore/yourgenes/howdogen

esaffectyourhealth/whyisstudyinggeneticsimportant

https://ghr.nlm.nih.gov/primer/hgp/elsi

https://www.yourgenome.org/facts/what-is-genetic-engineering