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Product Information Novel Kinase Inhibitors

for cell signaling & oncology research

Toll Free:
S1532 AZD7762 (877)796-6397
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» CHK Inhibitor
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Technical Data:
Orders
M.Wt: 362.42
NH2 +1-713-922-4115
Formula: C17H19FN4O2S O
enquiry@selleckchem.com
NH
Solubility: Unknown
HN
Purity: 99% Tech Support
F N
S O H tech@selleckchem.com
Storage: at -20℃ 2 years
(chemistry support)
CAS No.: 860352-01-8 techbio@selleckchem.com
(bio support)

Web
Biological Activity
www.selleckchem.com
AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2,
respectively. It significantly prolonged the median time required for tumor volume doubling in response to
gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous
recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they
support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with
locally advanced pancreatic cancer. [1] [2]
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References
Return Policy
[1] Morgan MA et al. Cancer Res. 2010 Jun 15;70(12):4972-81
Please inspect packages immediately upon
[2] Zabludoff SD et al. Mol Cancer Ther. 2008 Sep;7(9):2955-66
receipt and notify customer service within

3 days of delivery of any damage or

discrepancies.Our team will take quick and

appropriate action to correct any problem.

MSDS & CoA Goods ordered in error can only be accepted

Please visit www.selleckchem.com to download MSDS and CoA. for return if made within 3 days of delivery,

are unopened,have been stored correctly and

are in good condition. Should you wish to

return any item(s), prior authorization must

Notes be received from our customer service team.

Returns accepted will be subject to a 30%

restocking charge.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.

NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace-

ments,please contact Selleck directly by


Specific storage and handling information for each product is indicated on the product datasheet. Most Selleckchem products, stored under info@selleckchem.com or
the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended +1-713-922-4115.
storage temperature,most are recommended stored at -20℃.Many products are stable in the short-term at temperatures that differ from that Please have on hand, the invoice number,
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save purchase order number,air bill number and
your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage approximate date of shipment/receipt.
recommendations on the product data sheet.

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