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S1532 Azd7762
S1532 Azd7762
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S1532 AZD7762 (877)796-6397
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» CHK Inhibitor
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Technical Data:
Orders
M.Wt: 362.42
NH2 +1-713-922-4115
Formula: C17H19FN4O2S O
enquiry@selleckchem.com
NH
Solubility: Unknown
HN
Purity: 99% Tech Support
F N
S O H tech@selleckchem.com
Storage: at -20℃ 2 years
(chemistry support)
CAS No.: 860352-01-8 techbio@selleckchem.com
(bio support)
Web
Biological Activity
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AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2,
respectively. It significantly prolonged the median time required for tumor volume doubling in response to
gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous
recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they
support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with
locally advanced pancreatic cancer. [1] [2]
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References
Return Policy
[1] Morgan MA et al. Cancer Res. 2010 Jun 15;70(12):4972-81
Please inspect packages immediately upon
[2] Zabludoff SD et al. Mol Cancer Ther. 2008 Sep;7(9):2955-66
receipt and notify customer service within
Please visit www.selleckchem.com to download MSDS and CoA. for return if made within 3 days of delivery,
restocking charge.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. For all product returns and product replace-