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Gas exchange
Histopathologic examination of the left ear showed the retraction of the pars
flaccida (arrow), a pathology associated with fibrocystic changes, and
granulation tissue in the attic and mesotympanum (*).
Pathological Changes in the Middle Ear
Cleft in COM
• Biofilms
– Definition: structured communities of
microorganisms embedded in an
extrapolysaccharide matrix.
– Haemophilus influenzae, Streptococcus
pneumoniae, and Pseudomonas aeruginosa, have
been shown to form biofilms.
– important role in the establishment of COM that is
resistant to medications and for which surgical
intervention is often required.
The objectives of middle ear surgery
1. Removal of middle ear mucosa diseased.