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NanoElectronicPhotonicCircuits PDF
NanoElectronicPhotonicCircuits PDF
If “invent by increment” :
?
conductors (DNA wire?)
switches, active devices on
Molecular electronics (self assembly) molecular scale
Photonic superchip?
Two examples:
Nanoelectronic/photonic
Biological processor
processor
Interaction
and physical
integration
Neural network (e.g. brain) Nanoscience/nanotechnology:
as a massively parallel, large-scale non-silicon based
spatially distributed analog interactive, monolithic
computer transducer/receiver arrays
Develop massively parallel interfaces for (i) studying neuronal connectivity and
spatial organization; (ii) mapping that information onto nanoelectronic/photonic chips
for study of collective features to look for new computational functions
·Incorporation of results from theoretical models to guide the experimental system design
Year 5:
·Demonstration of a proof-of-concept computational device at the Bio/Info/Micro interface with integration
of cerebral cortex and nanoelectronics/microphotonics
Channel: 53 Channel: 54
Simultaneously Recorded
Channel: 52
Extracellular Action Potentials
(Mean/Standard Deviation)
Channel: 85 Channel: 92
Channel: 93 (Donoghue, Hatsopoulos et al)
60
40
40 20
20 20 10
0 0 0
20 40
Activity profiles 10
60
40
20
40
20 20
30
20
10
(peri-movement 0 0 0 0 0
10
50
medial 5
0
40
Simultaneously 0 20
0
60 rostral caudal
recorded neurons
frequency
100 100
30
50
(Hz)
50
0
-1.5 -0.5 0.5
0
lateral 0
time (s)
movement onset
Coupling of Brain to Micro/Optoelectronic Chips:
Interactive Computation at BioInfoMicro Interface
Decoding of Discrete and Continuous Movements of the Arm
Arm
Movements to Visual Targets
Targets
reconstruction actual position
18
17
Y position (cm)
16
15
14
13
12
11
10
9 10 11 12 13 14 15 16
X position (cm)
• A chronic physical interface with neural populations is feasible.
• Signals from randomly selected motor cortical neurons provide
extensive information about discrete motor behaviors as well as
continuous movement parameters (hand trajectory)
• Decoded cortical signals can be used to drive physical devices (robot
arms, computer cursors) in ~real time.
Coupling of Brain to Micro/Optoelectronic Chips:
Interactive Computation at BioInfoMicro Interface
Technical Example: Electrically coupled networks of neurons:
Inhibition, rhythms, and synchrony
RS
20 ì m
+ACP D c LTS vs FS
a 0 .6
Cross-corr elation
LTS
0 .0
FS
20
2 mV -0.6
250 ms
-4 00 - 20 0 0 200 40 0
Time (ms)
d e 0.8
RS vs R S
RS
Cross-correlation
0 .6
RS 0 .0
1 mV
250 ms -0. 6
Connors et al
-400 - 20 0 0 20 0 40 0 (2000)
Time (ms)
0.6
0.2
0
0.0
-0. 2
-25 0
-0 .4
-50 0 -0. 6
0 2 4 6 0 2 4 6 0 2 4 6
T ime (s)
RS
RS
2 mV
2s
• new generation of large area, high spatial resolution electrical (potential) probes
(J. Xu et al)
Coupling of Brain to Micro/Optoelectronic Chips:
Interactive Computation at BioInfoMicro Interface
(J. Xu et al)
Ti/NiFe/Au
Au contacts
wires
SiO2
Al
Ti (150A)/Au (2000A)
100 um SiO2
1-3um
CNTs
Ti (20A)/ NiFe/100A/Au
(150A)
and high speed, large scale optoelectronic probe/excite arrays (Nurmikko et al)
rare for high level neural theory to interact with physical level experimental observations
due to lack of detailed spatial and temporal recording over a large neuron ensemble
• Attractor networks connect and states in one network propagate into neighbors.
“interference patterns” formed when patterns collide become key information
processing elements. They are formed from combinations of lower level features