Professional Documents
Culture Documents
These pediatric hypertension guidelines are an update to the 2004 “Fourth abstract
Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure
in Children and Adolescents.” Significant changes in these guidelines
include (1) the replacement of the term “prehypertension” with the term
“elevated blood pressure,” (2) new normative pediatric blood pressure (BP) aDr. Robert O. Hickman Endowed Chair in Pediatric Nephrology,
Division of Nephrology, Department of Pediatrics, University of
tables based on normal-weight children, (3) a simplified screening table for Washington and Seattle Children's Hospital, Seattle, Washington;
bDepartments of Pediatrics, Internal Medicine, Population and
identifying BPs needing further evaluation, (4) a simplified BP classification Quantitative Health Sciences, Center for Clinical Informatics Research
in adolescents ≥13 years of age that aligns with the forthcoming American and Education, Case Western Reserve University and MetroHealth
System, Cleveland, Ohio; cDivision of Pediatric Cardiology, School of
Heart Association and American College of Cardiology adult BP guidelines, Medicine, University of Maryland, Baltimore, Maryland; dChildren’s
(5) a more limited recommendation to perform screening BP measurements Mercy Hospital, University of Missouri-Kansas City and Children’s
Mercy Integrated Care Solutions, Kansas City, Missouri; eDepartment
only at preventive care visits, (6) streamlined recommendations on the of Pediatrics, School of Medicine, Indiana University, Bloomington,
Indiana; fDepartment of Pediatrics, School of Medicine, University
initial evaluation and management of abnormal BPs, (7) an expanded role of Colorado-Denver and Pediatrician in Chief, Children’s Hospital
for ambulatory BP monitoring in the diagnosis and management of pediatric Colorado, Aurora, Colorado; gDirector, Preventive Cardiology Clinic,
Boston Children's Hospital, Department of Pediatrics, Harvard Medical
hypertension, and (8) revised recommendations on when to perform School, Boston, Massachusetts; hDivision of Nephrology, Department
of Pediatrics, University of British Columbia and British Columbia
echocardiography in the evaluation of newly diagnosed hypertensive Children’s Hospital, Vancouver, British Columbia, Canada; Departments
pediatric patients (generally only before medication initiation), along with a of iMedicine and Pediatrics, Sidney Kimmel Medical College, Thomas
Jefferson University, Philadelphia, Pennsylvania; jConsultant, American
revised definition of left ventricular hypertrophy. These guidelines include Academy of Pediatrics, Washington, District of Columbia; kCardiology
30 Key Action Statements and 27 additional recommendations derived Division Head, Nemours Cardiac Center, Alfred I. duPont Hospital for
Children, Wilmington, Delaware; lNational Pediatric Blood Pressure
from a comprehensive review of almost 15 000 published articles between Awareness Foundation, Prairieville, Louisiana; Departments of
mPediatrics and Biomedical Informatics and Medical Education,
January 2004 and July 2016. Each Key Action Statement includes level of University of Washington, University of Washington Medicine and
evidence, benefit-harm relationship, and strength of recommendation. This Information Technology Services, and Seattle Children's Hospital,
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TABLE 1 Continued
KAS Evidence Quality, Strength
of Recommendation
26. Children and adolescents with T1DM or T2DM should be evaluated for HTN at each medical encounter and treated if BP ≥95th C, moderate
percentile or >130/80 mm Hg in adolescents ≥13 y of age.
27. In children and adolescents with acute severe HTN and life-threatening symptoms, immediate treatment with short-acting Expert opinion, D, weak
antihypertensive medication should be initiated, and BP should be reduced by no more than 25% of the planned reduction over
the first 8 h.
28. Children and adolescents with HTN may participate in competitive sports once hypertensive target organ effects and C, moderate
cardiovascular risk have been assessed.
29. Children and adolescents with HTN should receive treatment to lower BP below stage 2 thresholds before participation in C, moderate
competitive sports.
30. Adolescents with elevated BP or HTN (whether they are receiving antihypertensive treatment) should typically have their care X, strong
transitioned to an appropriate adult care provider by 22 y of age (recognizing that there may be individual cases in which this
upper age limit is exceeded, particularly in the case of youth with special health care needs). There should be a transfer of
information regarding HTN etiology and past manifestations and complications of the patient’s HTN.
writing teams that evaluated the since 1988, indicate that there has Trajectory data on BP (including
evidence quality for selected topics been an increase in the prevalence repeat measurements from early
and generated appropriate KASs of childhood high BP, including childhood into midadulthood)
in accordance with an AAP grading both HTN and elevated BP.4,5 High confirm the association of elevated
matrix (see Fig 1 and the detailed BP is consistently greater in boys BP in adolescence with HTN in early
discussion in the forthcoming (15%–19%) than in girls (7%–12%). adulthood11 and that normal BP in
technical report).3 Special working The prevalence of high BP is higher childhood is associated with a lack of
groups were created to address 2 among Hispanic and non-Hispanic HTN in midadulthood.11
specific topics for which evidence African American children compared
was lacking and expert opinion with non-Hispanic white children, 2.2 Awareness, Treatment, and
was required to generate KASs, with higher rates among adolescents Control of HTN in Children
“Definition of HTN” and “Definition than among younger children.6
Of the 32.6% of US adults who
of LVH.” References for any topics not
However, in a clinical setting and have HTN, almost half (17.2%) are
covered by the key questions were
with repeated BP measurements, not aware they have HTN; even
selected on the basis of additional
the prevalence of confirmed HTN is among those who are aware of
literature searches and reviewed by
lower in part because of inherent BP their condition, only approximately
the epidemiologist and subcommittee
variability as well as an adjustment half (54.1%) have controlled BP.12
members assigned to the topic. When
to the experience of having BP Unfortunately, there are no large
applicable, searches were conducted
measured (also known as the studies in which researchers have
by using the PICOT format .
accommodation effect). Therefore, systematically studied BP awareness
In addition to the 30 KASs listed the actual prevalence of clinical or control in youth, although an
above, this guideline also contains HTN in children and adolescents analysis of prescribing patterns
27 additional recommendations is ∼3.5%.7,8 The prevalence of from a nationwide prescription drug
that are based on the consensus persistently elevated BP (formerly provider found an increase in the
expert opinion of the subcommittee termed “prehypertension,” including number of prescriptions written
members. These recommendations, BP values from the 90th to 94th for high BP in youth from 2004 to
along with their locations in the percentiles or between 120/80 and 2007.13
document, are listed in Table 2. 130/80 mm Hg in adolescents) is also
The SEARCH for Diabetes in Youth
∼2.2% to 3.5%, with higher rates
study found that only 7.4% of
among children and adolescents who
2. Epidemiology and Clinical youth with type 1 diabetes mellitus
have overweight and obesity.7,9
Significance (T1DM) and 31.9% of youth with
Data on BP tracking from childhood type 2 diabetes mellitus (T2DM)
2.1 Prevalence of HTN in Children to adulthood demonstrate that demonstrated knowledge of their
Information on the prevalence higher BP in childhood correlates BP status.14 Even after becoming
of high blood pressure (BP) in with higher BP in adulthood aware of the diagnosis, only 57.1%
children is largely derived from data and the onset of HTN in young of patients with T1DM and 40.6% of
from the NHANES and typically is adulthood. The strength of the patients with T2DM achieved good
based on a single BP measurement tracking relationship is stronger in BP control.14 The HEALTHY Primary
session. These surveys, conducted older children and adolescents.10 Prevention Trial of Risk Factors for
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TABLE 2 Continued latter in pediatric patients is lacking.
Recommendation CPG Among children and adolescents
Section(s) with CKD, ∼50% are known to be
26. Reasonable strategies for HTN prevention include the maintenance of a normal 13.2 hypertensive.46– 48
In children and
BMI, consuming a DASH-type diet, avoidance of excessive sodium consumption, and
regular vigorous physical activity.
adolescents with end-stage renal
27. Provide education about HTN to patients and their parents to improve patient 15.2, 15.3 disease (either those on dialysis
involvement in their care and better achieve therapeutic goals. or after transplant), ∼48% to 79%
Based on the expert opinion of the subcommittee members (level of evidence = D; strength of recommendations = weak). are hypertensive, with 20% to 70%
CPG, clinical practice guideline. having uncontrolled HTN.49– 53
Almost 20% of pediatric HTN may be
of abdominal adiposity28 have hard to demonstrate definitively, attributable to CKD.54
shown associations between these the Strong Heart Study did show
conditions and HTN. Obesity is also that American Indian adolescents 2.3d Children With History of
associated with a lack of circadian with multiple cardiometabolic risk Prematurity
variability of BP,29,30 with up to 50% factors had a higher prevalence of Abnormal birth history—including
of children who have obesity not LVH (43.2% vs 11.7%), left atrial preterm birth and low birth weight—
experiencing the expected nocturnal dilation (63.1% vs 21.9%; P < .001), has been identified as a risk factor for
BP dip.31–33
and reduced LV systolic and diastolic HTN and other CVD in adults55; only
Studies have shown that childhood function compared with those low birth weight has been associated
obesity is also related to the without multiple cardiometabolic with elevated BP in the pediatric age
development of future HTN.22 risk factors.39 Notably, both obesity range.56 One retrospective cohort
Elevated BMI as early as infancy and HTN were drivers of these CV study showed a prevalence of HTN
is associated with higher future abnormalities, with obesity being of 7.3% among 3 year olds who
BP.34 This risk appears to increase a stronger determinant of cardiac were born preterm.57 Researchers
with obesity severity; there is a abnormalities than HTN (odds ratio, in another retrospective case series
fourfold increase in BP among those 4.17 vs 1.03). noted a high prevalence of HTN
with severe obesity (BMI >99th in older children with a history of
2.3b Children With SDB preterm birth.58 It also appears that
percentile) versus a twofold increase
in those with obesity (BMI 95th–98th SDB occurs on a spectrum that preterm birth may result in abnormal
percentiles) compared with normal- includes (1) primary snoring, circadian BP patterns in childhood.59
weight children and adolescents.35 (2) sleep fragmentation, and (3) These data are intriguing but limited.
obstructive sleep apnea syndrome Further study is needed to determine
Collectively, the results of these (OSAS). Researchers in numerous how often preterm birth results in
cross-sectional and longitudinal studies have identified an association childhood HTN.
studies firmly establish an increasing between SDB and HTN in the
prevalence of HTN with increasing pediatric population.40– 42
Studies 2.4 Importance of Diagnosing HTN in
BMI percentile. The study results suggest that children who sleep Children and Adolescents
also underscore the importance of 7 hours or less per night are at Numerous studies have shown that
monitoring BP in all children with increased risk for HTN.43 Small elevated BP in childhood increases
overweight and/or obesity at every studies of youth with sleep disorders the risk for adult HTN and metabolic
clinical encounter. have found the prevalence of high BP – 62
syndrome.10,60 Youth with higher
Obesity in children with HTN may to range between 3.6% and 14%.40,41 BP levels in childhood are also more
be accompanied by additional The more severe the OSAS, the more likely to have persistent HTN as
cardiometabolic risk factors (eg, likely a child is to have HTN.44,45 adults.60,63 One recent study found
dyslipidemia and disordered glucose Even inadequate duration of sleep that adolescents with elevated
metabolism)36,37 that may have their and poor-quality sleep have been BP progressed to HTN at a rate
own effects on BP or may represent associated with elevated BP.43 of 7% per year, and elevated BMI
comorbid conditions arising from the predicted sustained BP elevations.64
same adverse lifestyle behaviors.25,38
2.3c Children With CKD In addition, young patients with HTN
Some argue that the presence of There are well-established are likely to experience accelerated
multiple risk factors, including pathophysiologic links between vascular aging. Both autopsy65 and
obesity and HTN, leads to far greater childhood HTN and CKD. Certain imaging studies66 have demonstrated
increases in CV risk than is explained forms of CKD can lead to HTN, and BP-related CV damage in youth.
by the individual risk factors alone. untreated HTN can lead to CKD in These intermediate markers of CVD
Although this phenomenon has been adults, although evidence for the (eg, increased LV mass,67 cIMT,68 and
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Fourth Report,1 they include SBP and understand that the scheme in Table In an attempt to develop a more
DBP values arranged by age, sex, and 3 was chosen to align with the new standardized approach to the HTN
height (and height percentile). These adult guideline and facilitate the definition in preterm and term
values are based on auscultatory management of older adolescents neonates, Dionne et al79 compiled
measurements obtained from with high BP. The percentile- available data on neonatal BP and
∼50 000 children and adolescents. A based values in Tables 4 and 5 are generated a summary table of BP
new feature in these tables is that the provided to aid researchers and values, including values for the 95th
BP values are categorized according others interested in a more precise and 99th percentiles for infants from
to the scheme presented in Table 3 classification of BP. 26 to 44 weeks’ postmenstrual age.
as normal (50th percentile), elevated The authors proposed that by using
BP (>90th percentile), stage 1 HTN 3.2a. Simplified BP Table these values, a similar approach to
(≥95th percentile), and stage 2 HTN This guideline includes a new, that used to identify older children
(≥95th percentile + 12 mm Hg). simplified table for initial BP with elevated BP can be followed in
Additionally, actual heights in screening (see Table 6) based on neonates, even in those who are born
centimeters and inches are provided. the 90th percentile BP for age and preterm.
sex for children at the 5th percentile
Unlike the tables in the Fourth At present, no alternative data have
of height, which gives the values in
Report,1 the BP values in these been developed, and no outcome data
the table a negative predictive value
tables do not include children and are available on the consequences of
of >99%.78 This simplified table is
adolescents with overweight and high BP in this population; thus, it is
designed as a screening tool only
obesity (ie, those with a BMI ≥85th reasonable to use these compiled BP
for the identification of children
percentile); therefore, they represent values in the assessment of elevated
and adolescents who need further
normative BP values for normal- BP in newborn infants. Of note, the
evaluation of their BP starting with
weight youth. The decision to create 1987 “Report of the Second Task
repeat BP measurements. It should
these new tables was based on Force on Blood Pressure Control
not be used to diagnose elevated
evidence of the strong association in Children” published curves
BP or HTN by itself. To diagnose
of both overweight and obesity with of normative BP values in older
elevated BP or HTN, it is important
elevated BP and HTN. Including infants up to 1 year of age.81 These
to locate the actual cutoffs in the
patients with overweight and normative values should continue
complete BP tables because the SBP
obesity in normative BP tables was to be used given the lack of more
and DBP cutoffs may be as much as 9
thought to create bias. The practical contemporary data for this age group.
mm Hg higher depending on a child’s
effect of this change is that the BP
age and length or height. A typical-
values in Tables 4 and 5 are several
use case for this simplified table is
millimeters of mercury lower than 4. Measurement of BP
for nursing staff to quickly identify
in the similar tables in the Fourth
BP that may need further evaluation
Report.1 These tables are based on 4.1 BP Measurement Technique
by a clinician. For adolescents ≥13
the same population data excluding
years of age, a threshold of 120/80 BP in childhood may vary
participants with overweight and
mm Hg is used in the simplified considerably between visits and
obesity, and the same methods used
table regardless of sex to align with even during the same visit. There
in the Fourth Report.1 The methods
adult guidelines for the detection of are many potential etiologies for
and results have been published
elevated BP. isolated elevated BP in children and
elsewhere.77 For researchers and
adolescents, including such factors as
others interested in the equations 3.3 Definition of HTN in the Neonate anxiety and recent caffeine intake.82
used to calculate the tables’ BP and Infant (0–1 Year of Age) BP generally decreases with repeated
values, detailed methodology and
Although a reasonably strict measurements during a single visit,83
the Statistical Analysis System (SAS)
definition of HTN has been developed although the variability may
code can be found at: http://sites.
for older children, it is more difficult not be large enough to affect BP
google.com/a/channing.harvard.
to define HTN in neonates given the classification.84 BP measurements
edu/bernardrosner/pediatric-blood-
well-known changes in BP that occur can also vary across visits64,85; one
press/childhood-blood-pressure.
during the first few weeks of life.79 study in adolescents found that only
There are slight differences between These BP changes can be significant 56% of the sample had the same
the actual percentile-based values in preterm infants, in whom BP HTN stage on 3 different occasions.8
in these tables and the cut-points in depends on a variety of factors, Therefore, it is important to obtain
Table 3, particularly for teenagers including postmenstrual age, birth multiple measurements over time
≥13 years of age. Clinicians should weight, and maternal conditions.80 before diagnosing HTN.
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95th 104 105 105 106 107 107 108 57 58 58 59 60 61 61
95th + 12 mm Hg 116 117 117 118 119 119 120 69 70 70 71 72 73 73
3 Height (in) 36.4 37 37.9 39 40.1 41.1 41.7 36.4 37 37.9 39 40.1 41.1 41.7
Height (cm) 92.5 93.9 96.3 99 101.8 104.3 105.8 92.5 93.9 96.3 99 101.8 104.3 105.8
50th 88 89 89 90 91 92 92 45 46 46 47 48 49 49
90th 101 102 102 103 104 105 105 58 58 59 59 60 61 61
95th 106 106 107 107 108 109 109 60 61 61 62 63 64 64
95th + 12 mm Hg 118 118 119 119 120 121 121 72 73 73 74 75 76 76
4 Height (in) 38.8 39.4 40.5 41.7 42.9 43.9 44.5 38.8 39.4 40.5 41.7 42.9 43.9 44.5
Height (cm) 98.5 100.2 102.9 105.9 108.9 111.5 113.2 98.5 100.2 102.9 105.9 108.9 111.5 113.2
50th 90 90 91 92 93 94 94 48 49 49 50 51 52 52
90th 102 103 104 105 105 106 107 60 61 62 62 63 64 64
95th 107 107 108 108 109 110 110 63 64 65 66 67 67 68
95th + 12 mm Hg 119 119 120 120 121 122 122 75 76 77 78 79 79 80
5 Height (in) 41.1 41.8 43.0 44.3 45.5 46.7 47.4 41.1 41.8 43.0 44.3 45.5 46.7 47.4
Height (cm) 104.4 106.2 109.1 112.4 115.7 118.6 120.3 104.4 106.2 109.1 112.4 115.7 118.6 120.3
50th 91 92 93 94 95 96 96 51 51 52 53 54 55 55
90th 103 104 105 106 107 108 108 63 64 65 65 66 67 67
95th 107 108 109 109 110 111 112 66 67 68 69 70 70 71
95th + 12 mm Hg 119 120 121 121 122 123 124 78 79 80 81 82 82 83
6 Height (in) 43.4 44.2 45.4 46.8 48.2 49.4 50.2 43.4 44.2 45.4 46.8 48.2 49.4 50.2
Height (cm) 110.3 112.2 115.3 118.9 122.4 125.6 127.5 110.3 112.2 115.3 118.9 122.4 125.6 127.5
9
10
TABLE 4 Continued
Age (y) BP Percentile SBP (mm Hg) DBP (mm Hg)
Height Percentile or Measured Height Height Percentile or Measured Height
5% 10% 25% 50% 75% 90% 95% 5% 10% 25% 50% 75% 90% 95%
8 Height (in) 47.8 48.6 50 51.6 53.2 54.6 55.5 47.8 48.6 50 51.6 53.2 54.6 55.5
Height (cm) 121.4 123.5 127 131 135.1 138.8 141 121.4 123.5 127 131 135.1 138.8 141
50th 95 96 97 98 99 99 100 57 57 58 59 59 60 60
90th 107 108 109 110 111 112 112 69 70 70 71 72 72 73
95th 111 112 112 114 115 116 117 72 73 73 74 75 75 75
95th + 12 mm Hg 123 124 124 126 127 128 129 84 85 85 86 87 87 87
9 Height (in) 49.6 50.5 52 53.7 55.4 56.9 57.9 49.6 50.5 52 53.7 55.4 56.9 57.9
Height (cm) 126 128.3 132.1 136.3 140.7 144.7 147.1 126 128.3 132.1 136.3 140.7 144.7 147.1
50th 96 97 98 99 100 101 101 57 58 59 60 61 62 62
90th 107 108 109 110 112 113 114 70 71 72 73 74 74 74
95th 112 112 113 115 116 118 119 74 74 75 76 76 77 77
95th + 12 mm Hg 124 124 125 127 128 130 131 86 86 87 88 88 89 89
10 Height (in) 51.3 52.2 53.8 55.6 57.4 59.1 60.1 51.3 52.2 53.8 55.6 57.4 59.1 60.1
Height (cm) 130.2 132.7 136.7 141.3 145.9 150.1 152.7 130.2 132.7 136.7 141.3 145.9 150.1 152.7
50th 97 98 99 100 101 102 103 59 60 61 62 63 63 64
90th 108 109 111 112 113 115 116 72 73 74 74 75 75 76
95th 112 113 114 116 118 120 121 76 76 77 77 78 78 78
95th + 12 mm Hg 124 125 126 128 130 132 133 88 88 89 89 90 90 90
11 Height (in) 53 54 55.7 57.6 59.6 61.3 62.4 53 54 55.7 57.6 59.6 61.3 62.4
Height (cm) 134.7 137.3 141.5 146.4 151.3 155.8 158.6 134.7 137.3 141.5 146.4 151.3 155.8 158.6
50th 99 99 101 102 103 104 106 61 61 62 63 63 63 63
90th 110 111 112 114 116 117 118 74 74 75 75 75 76 76
95th 114 114 116 118 120 123 124 77 78 78 78 78 78 78
95th + 12 mm Hg 126 126 128 130 132 135 136 89 90 90 90 90 90 90
12 Height (in) 55.2 56.3 58.1 60.1 62.2 64 65.2 55.2 56.3 58.1 60.1 62.2 64 65.2
Height (cm) 140.3 143 147.5 152.7 157.9 162.6 165.5 140.3 143 147.5 152.7 157.9 162.6 165.5
50th 101 101 102 104 106 108 109 61 62 62 62 62 63 63
90th 113 114 115 117 119 121 122 75 75 75 75 75 76 76
95th 116 117 118 121 124 126 128 78 78 78 78 78 79 79
95th + 12 mm Hg 128 129 130 133 136 138 140 90 90 90 90 90 91 91
13 Height (in) 57.9 59.1 61 63.1 65.2 67.1 68.3 57.9 59.1 61 63.1 65.2 67.1 68.3
Height (cm) 147 150 154.9 160.3 165.7 170.5 173.4 147 150 154.9 160.3 165.7 170.5 173.4
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95th 130 131 133 134 135 136 137 80 81 83 84 85 86 86
95th + 12 mm Hg 142 143 145 146 147 148 149 92 93 95 96 97 98 98
17 Height (in) 64.5 65.5 67.3 69.2 71.1 72.8 73.8 64.5 65.5 67.3 69.2 71.1 72.8 73.8
Height (cm) 163.8 166.5 170.9 175.8 180.7 184.9 187.5 163.8 166.5 170.9 175.8 180.7 184.9 187.5
50th 114 115 116 117 117 118 118 65 66 67 68 69 70 70
90th 128 129 130 131 132 133 134 78 79 80 81 82 82 83
95th 132 133 134 135 137 138 138 81 82 84 85 86 86 87
95th + 12 mm Hg 144 145 146 147 149 150 150 93 94 96 97 98 98 99
Use percentile values to stage BP readings according to the scheme in Table 3 (elevated BP: ≥90th percentile; stage 1 HTN: ≥95th percentile; and stage 2 HTN: ≥95th percentile + 12 mm Hg). The 50th, 90th, and 95th percentiles were derived by using
quantile regression on the basis of normal-weight children (BMI <85th percentile).77
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95th 112 112 113 114 116 117 118 74 74 75 75 75 75 75
95th + 12 mm Hg 124 124 125 126 128 129 130 86 86 87 87 87 87 87
10 Height (in) 51.1 52 53.7 55.5 57.4 59.1 60.2 51.1 52 53.7 55.5 57.4 59.1 60.2
Height (cm) 129.7 132.2 136.3 141 145.8 150.2 152.8 129.7 132.2 136.3 141 145.8 150.2 152.8
50th 96 97 98 99 101 102 103 58 59 59 60 61 61 62
90th 109 110 111 112 113 115 116 72 73 73 73 73 73 73
95th 113 114 114 116 117 119 120 75 75 76 76 76 76 76
95th + 12 mm Hg 125 126 126 128 129 131 132 87 87 88 88 88 88 88
11 Height (in) 53.4 54.5 56.2 58.2 60.2 61.9 63 53.4 54.5 56.2 58.2 60.2 61.9 63
Height (cm) 135.6 138.3 142.8 147.8 152.8 157.3 160 135.6 138.3 142.8 147.8 152.8 157.3 160
50th 98 99 101 102 104 105 106 60 60 60 61 62 63 64
90th 111 112 113 114 116 118 120 74 74 74 74 74 75 75
95th 115 116 117 118 120 123 124 76 77 77 77 77 77 77
95th + 12 mm Hg 127 128 129 130 132 135 136 88 89 89 89 89 89 89
12 Height (in) 56.2 57.3 59 60.9 62.8 64.5 65.5 56.2 57.3 59 60.9 62.8 64.5 65.5
Height (cm) 142.8 145.5 149.9 154.8 159.6 163.8 166.4 142.8 145.5 149.9 154.8 159.6 163.8 166.4
50th 102 102 104 105 107 108 108 61 61 61 62 64 65 65
90th 114 115 116 118 120 122 122 75 75 75 75 76 76 76
95th 118 119 120 122 124 125 126 78 78 78 78 79 79 79
95th + 12 mm Hg 130 131 132 134 136 137 138 90 90 90 90 91 91 91
13 Height (in) 58.3 59.3 60.9 62.7 64.5 66.1 67 58.3 59.3 60.9 62.7 64.5 66.1 67
Height (cm) 148.1 150.6 154.7 159.2 163.7 167.8 170.2 148.1 150.6 154.7 159.2 163.7 167.8 170.2
50th 104 105 106 107 108 108 109 62 62 63 64 65 65 66
13
The initial BP measurement may
Use percentile values to stage BP readings according to the scheme in Table 3 (elevated BP: ≥90th percentile; stage 1 HTN: ≥95th percentile; and stage 2 HTN: ≥95th percentile + 12 mm Hg). The 50th, 90th, and 95th percentiles were derived by using
be oscillometric (on a calibrated
68.4
173.7
68.3
173.4
68.1
95%
94
94
67
78
82
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82
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82
94
173
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machine that has been validated for
use in the pediatric population) or
auscultatory (by using a mercury or
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171.3
67.3
171.1
67.2
170.6
90%
94
66
78
82
67
78
82
94
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94
aneroid sphygmomanometer86,87 ).
(Validation status for oscillometric
Height Percentile or Measured Height
65.9
167.4
65.8
167.1
65.6
166.7
75%
94
66
78
82
66
78
82
94
66
77
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94
dableducational.org.) BP should be
64.2
163.0
64.1
162.8
63.9
162.3
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66
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81
93
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81
93
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93
66
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youtu.be/JLzkNBpqwi0. Care
should be taken that providers
follow an accurate and consistent
68.4
173.7
68.3
173.4
68.1
95%
128
140
140
111
125
140
110
124
128
173
109
124
128
measurement technique.88,89
An appropriately sized cuff should be
67.4
171.3
67.3
171.1
67.2
170.6
128
140
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140
110
125
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90°86,95,
96 ) should be obtained for an
accurate determination of the correct
95th + 12 mm Hg
95th + 12 mm Hg
95th + 12 mm Hg
Height (cm)
Height (cm)
Height (cm)
Height (in)
Height (in)
Height (in)
95th
50th
90th
50th
90th
95th
50th
90th
95th
or auscultatory BP measurements
at the same visit and average them.
If using auscultation, this averaged
Age (y)
4.1a Measurement of BP in the Neonate and toddlers). Normative values for Offices that will be obtaining BP
Multiple methods are available neonatal and infant BP have generally measurements in neonates need to
for the measurement of BP in been determined in the right upper have a variety of cuff sizes available.
hospitalized neonates, including arm with the infant supine, and a In addition, the oscillometric device
direct intra-arterial measurements similar approach should be followed used should be validated in neonates
using indwelling catheters as well in the outpatient setting. and programmed to have an initial
as indirect measurements using inflation value appropriate for
the oscillometric technique. In the As with older children, proper infants (generally ≤120 mm Hg).
office, however, the oscillometric cuff size is important in obtaining Auscultation becomes technically
technique typically is used at least accurate BP readings in neonates. feasible once the infant’s upper arm
until the infant is able to cooperate The cuff bladder length should is large enough for the smallest cuff
with manual BP determination encircle 80% to 100% of the arm available for auscultatory devices.
(which also depends on the ability circumference; a cuff bladder with a Measurements are best taken when
of the individual measuring the BP width-to-arm circumference ratio of the infant is in a calm state; multiple
to obtain auscultatory BP in infants 0.45 to 0.55 is recommended.79,97,
98
readings may be needed if the first
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to increase BP (see Table 8 and the
“Secondary Causes: Medication-
related” section of this guideline).112,113
Children younger than 3 years should
have BP measurements taken at
well-child care visits if they are at
increased risk for developing HTN
(see Table 9).1
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Key Action Statement 3. Trained health care professionals in the office setting decision support in conjunction with
should make a diagnosis of HTN if a child or adolescent has auscultatory- an EHR in adult populations has also
confirmed BP readings ≥95th percentile on 3 different visits (grade C, moderate been associated with improved BP
recommendation). screening, recognition, medication
Aggregate Evidence Quality Grade C prescribing, and control; pediatric
Benefits Early detection of HTN; prevention of CV morbidity in predisposed data are limited, however.122– 125
children and adolescents; identification of secondary causes of HTN Some studies failed to show
Risks, harm, cost Overtesting, misclassification, unnecessary treatment, discomfort from improvement in BP screening or
BP measurement, time involved in taking BP
control,122,126 but given the inherent
Benefit–harm assessment Benefits of repeated BP measurement exceeds potential harm
Intentional vagueness None complexity in the interpretation
Role of patient preferences Families may have varying levels of concern about elevated BP readings of pediatric BP measurements,
and may request evaluation on a different time line EHRs should be designed to flag
Exclusions None abnormal values both at the time of
Strength Moderate recommendation
measurement and on entry into the
Key references 8,84,85
EHR.
be referred to subspecialty care One analysis using nationally Key Action Statement 4
within 1 week (see Table 11); and representative survey data found
that providers measured BP at only Organizations with EHRs used in
3. If the BP reading is at the stage an office setting should consider
67% of preventive visits for children
2 HTN level and the patient is including flags for abnormal BP
3 to 18 years of age. Older children
symptomatic, or the BP is >30 values both when the values are
and children with overweight or
mm Hg above the 95th percentile being entered and when they
obesity were more likely to be
(or >180/120 mm Hg in an are being viewed (grade C, weak
screened.117 In a large cohort study
adolescent), refer to an immediate recommendation).
of 14 187 children, 507 patients met
source of care, such as an
the criteria for HTN, but only 131
emergency department (ED).
(26%) had the diagnosis documented 4.5 Oscillometric Versus
Key Action Statement 3 in their electronic health records Auscultatory (Manual) BP
(EHRs). Elevated BP was only Measurement
Trained health care professionals
recognized in 11% of cases.7 Although pediatric normative BP
in the office setting should make
a diagnosis of HTN if a child or data are based on auscultatory
It is likely that the low rates of
adolescent has auscultatory- measurements, oscillometric BP
screening and diagnosis of pediatric
confirmed BP readings ≥95th devices have become commonplace
HTN are related, at least in part, to
percentile on 3 different visits (grade in health care settings.127 Ease of
the need to use detailed reference
C, moderate recommendation). use, a lack of digit preference, and
tables incorporating age, sex, and
automation are all perceived benefits
height to classify BP levels.118
4.4 Use of Electronic Health Records of using oscillometric devices. Unlike
Studies have shown that using
auscultatory measurement, however,
Studies have demonstrated that health information technology
oscillometric devices measure
primary care providers frequently can increase adherence to clinical
the oscillations transmitted from
fail to measure BP and often guidelines and improve practitioner
disrupted arterial flow by using the
underdiagnose HTN.85,115,
116
performance.119– 121
In fact, applying
cuff as a transducer to determine
mean arterial pressure (MAP). Rather
than directly measuring any pressure
Key Action Statement 4. Organizations with EHRs used in an office setting should
that correlates to SBP or DBP, the
consider including flags for abnormal BP values both when the values are being
device uses a proprietary algorithm
entered and when they are being viewed (grade C, weak recommendation).
to calculate these values from the
Aggregate Evidence Quality Grade C
directly measured MAP.127 Because
Benefits Improved rate of screening and recognition of elevated BP
Risks, harm, cost Cost of EHR development, alert fatigue the algorithms vary for different
Benefit–harm assessment Benefit of EHR flagging of elevated BP outweighs harm from brands of oscillometric devices, there
development cost and potential for alert fatigue is no standard oscillometric BP.128
Intentional vagueness None
Role of patient preferences None Researchers in several studies
Exclusions None have evaluated the accuracy of
Strength Weak recommendation (because of a lack of pediatric data) – 134
oscillometric devices127,129
Key references 7,117,120,125
and compared auscultatory and
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TABLE 11 Patient Evaluation and Management According to BP Level ventricular mass index (LVMI) than
BP Category BP Screening Lifestyle Check ABPMa Diagnostic Initiate Consider systolic office BP.138,139
(See Table Schedule Counseling Upper Evaluationb Treatmentc Subspecialty
3) (Weight and and Referral
Although many wrist devices have
Nutrition) Lower been validated in adults,140– 142
some
Extremity studies have shown greater variation
BP and decreased accuracy in the
Normal Annual X — — — — — resulting measurements.143– 146 These
Elevated BP Initial X — — — — — negative outcomes may possibly
measurement result from differences in the number
Second X X — — — —
of measurements taken,139 the
measurement:
repeat in 6 mo position of the wrist in relation to
Third X — X X — X the heart,147 flexion or extension of
measurement: the wrist during measurement,148
repeat in 6 mo or differences in pulse pressure.149
Stage 1 HTN Initial X — — — — —
measurement
Technologies are being developed to
Second X X — — — — help standardize wrist position.150,151
measurement:
repeat in 1–2 Few studies using wrist monitors
wk have been conducted in children.
Third X — X X X X One study in adolescents compared
measurement:
repeat in 3 mo
a wrist digital monitor with a
Stage 2 HTNd Initial X X — — — — mercury sphygmomanometer and
measurement found high agreement between
Second X — X X X X systolic measurements but
measurement: lower agreement for diastolic
repeat, refer
to specialty
measurements, which was clinically
care within relevant.152 Researchers in 2
1 wk small studies conducted in PICUs
X, recommended intervention; —, not applicable. compared wrist monitors with
a ABPM is done to confirm HTN before initiating a diagnostic evaluation.
indwelling arterial lines and found
b See Table 15 for recommended studies.
c Treatment may be initiated by a primary care provider or subspecialist.
good agreement between the 2
d If the patient is symptomatic or BP is >30 mm Hg above the 95th percentile (or >180/120 mm Hg in an adolescent), send measurement modalities.153,154
No
to an ED. large comparative studies or formal
validation studies of wrist monitors
and adolescents. When doing so, BP measurements, equivalence have been conducted in children,
providers should use a device that to readings obtained by mercury however. Because of limited data, the
has been validated in the pediatric sphygmomanometers or ABPM, use of wrist and forearm monitors is
age group. If elevated BP is suspected and better correlation with left not recommended in the diagnosis or
on the basis of oscillometric readings,
confirmatory measurements should Key Action Statement 5. Oscillometric devices may be used for BP screening in
be obtained by auscultation (grade B, children and adolescents. When doing so, providers should use a device that has
strong recommendation). been validated in the pediatric age group. If elevated BP is suspected on the basis
of oscillometric readings, confirmatory measurements should be obtained by
auscultation (grade B, strong recommendation).
4.6 Forearm and/or Wrist BP
Measurement Aggregate Evidence Quality Grade B
Benefits Use of auscultatory readings prevents potential misclassification of
Wrist monitors have several potential patients as hypertensive because of inaccuracy of oscillometric
advantages when compared with arm devices
devices. They are smaller; they can Risks, harm, cost Auscultation requires more training and experience and has flaws such
be placed more easily; and, because as digit preference
Benefit–harm assessment Benefit exceeds harm
wrist diameter is less affected by Intentional vagueness None
BMI, they do not need to be modified Role of patient preferences Patients may prefer the convenience of oscillometric monitors
for patients with obesity.83,137
Exclusions None
Several studies in adults have found Strength Strong recommendation
excellent reproducibility of wrist Key references 86,88,128–136
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and adolescents with office BP that compared with those with with established HTN.209 Most (but
measurements in the elevated BP normal 24-hour BP, these patients not all) studies suggest that WCH
category for 1 year or more or with have significant risk for end organ is not associated with increased
stage 1 HTN over 3 clinic visits (grade hypertensive damage.200,203
Patients LV mass.200,207,
210 Although the
C, moderate recommendation). who are at risk of MH include distinction between WCH and true
For technical reasons, ABPM may patients with obesity and secondary HTN is important, abnormal BP
need to be limited to children ≥5 forms of HTN, such as CKD or response to exercise and increased
years of age who can tolerate the repaired aortic coarctation. MH is LVM has been found to occur in
procedure and those for whom particularly prevalent in patients children with WCH.207 Furthermore,
reference data are available. with CKD48 and is associated with the identification of WCH may reduce
target organ damage.203 Children costs by reducing the number of
Key Action Statement 7 with CKD should be periodically additional tests performed and
evaluated using ABPM for MH as decreasing the number of children
The routine performance of ABPM
part of routine CKD who are exposed to antihypertensive
should be strongly considered
– 206
management.201,204 medications.208 Children and
in children and adolescents with
adolescents with WCH should
high-risk conditions (see Table
have screening BP measured at
12) to assess HTN severity and 4.7b White Coat Hypertension
regular well-child care visits with
determine if abnormal circadian BP
WCH is defined as BP ≥95th consideration of a repeat ABPM in 1
patterns are present, which may
percentile in the office or clinical to 2 years.
indicate increased risk for target
setting but <95th percentile outside
organ damage (grade B, moderate Key Action Statement 9
of the office or clinical setting.
recommendation).
WCH is diagnosed by ABPM when Children and adolescents with
Key Action Statement 8 the mean SBP and DBP are <95th suspected WCH should undergo
percentile and SBP and DBP load ABPM. Diagnosis is based on the
ABPM should be performed by using
are <25%; load is defined as the presence of mean SBP and DBP
a standardized approach (see Table
percentage of valid ambulatory BP <95th percentile and SBP and
13) with monitors that have been
measurements above a set threshold DBP load <25% (grade B, strong
validated in a pediatric population,
value (eg, 95th percentile) for recommendation).
and studies should be interpreted by
age, sex, and height.155,156,
206 It is
using pediatric normative data (grade
estimated that up to half of children
C, moderate recommendation). 4.8 Measurement in Children With
who are evaluated for elevated office
BP have WCH.207,208 Obesity
4.7a Masked Hypertension
Accurate BP measurement can be
MH occurs when patients have In adults, compared with
challenging in individuals with
normal office BP but elevated BP on normotension, WCH is associated
obesity. 23,211,
212 Elevated BMI
ABPM, and it has been found in 5.8% with only a slightly increased risk
in children and adolescents is
of unselected children studied by of adverse outcomes but at a much
associated with an increase in the
ABPM.199 There is growing evidence lower risk compared with those
midarm circumference,96 requiring
the use of a larger cuff to obtain
Key Action Statement 6. ABPM should be performed for the confirmation of HTN accurate BP measurements.83 During
in children and adolescents with office BP measurements in the elevated BP NHANES 2007–2010, among children
category for 1 year or more or with stage 1 HTN over 3 clinic visits (grade C,
9 to 11 years of age with obesity,
moderate recommendation).
one-third of boys and one-quarter of
Aggregate Evidence Quality Grade C girls required an adult BP cuff, and
Benefits Avoids unnecessarily exposing youth with WCH to extensive diagnostic
testing or medication
a fraction required a large adult cuff
Risks, harm, cost Risk of discomfort to patient. Some insurance plans may not reimburse or an adult thigh cuff for an accurate
for the test measurement of BP.213 Researchers
Benefit–harm assessment The risk of ABPM is lower than the risk of unnecessary treatment. The in studies of adults have also noted
use of ABPM has also been shown to be more cost-effective than other
the influence of the conical upper
approaches to diagnosing HTN
Intentional vagueness None arm shape on BP measurements in
Role of patient preferences Some patients may prefer repeat office or home measurements to ABPM people with obesity.214,215
ABPM is a
Exclusions None valuable tool in the diagnosis of HTN
Strength Moderate recommendation in children with obesity because of
Key references 23,155,158,159
the discrepancies between casual and
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Key Action Statement 9. Children and adolescents with suspected WCH should evaluation for secondary causes of
undergo ABPM. Diagnosis is based on the presence of mean SBP and DBP <95th HTN if they have a positive family
percentile and SBP and DBP load <25% (grade B, strong recommendation). history of HTN, are overweight or
Aggregate Evidence Quality Grade B (Evidence Level A in Adults) obese, and/or do not have history
Benefits Improved diagnosis of WCH and the benefit of fewer additional or physical examination findings
laboratory tests and/or treatment of primary HTN. Costs might be (Table 14) suggestive of a secondary
reduced if the treatment of those misdiagnosed as hypertensive is
prevented
cause of HTN (grade C, moderate
Risks, harm, cost Additional costs; costs may not be covered by insurance companies. recommendation).
The ambulatory BP monitor is uncomfortable for some patients
Benefit–harm assessment Benefit exceeds risk
5.2 Secondary Causes: Renal and/or
Intentional vagueness None
Role of patient preferences Important; some patients may not want to undergo ABPM. Benefits
Renovascular
of the procedure should be reviewed with families to assist in Renal disease and renovascular
decision-making
disease are among the most common
Exclusions None
Strength Strong recommendation secondary causes of HTN in children.
Key references 206 Renal parenchymal disease and
renal structural abnormalities
Key Action Statement 10. Home BP monitoring should not be used to diagnose accounted for 34% to 79% of
HTN, MH, or WCH but may be a useful adjunct to office and ambulatory patients with secondary HTN in 3
BP measurement after HTN has been diagnosed (grade C, moderate retrospective, single-center case
recommendation). series, and renovascular disease was
Aggregate Evidence Quality Grade C present in 12% to 13%.101,240,
241
Benefits Convenient, cost-effective, widely available, can be used over time The literature suggests that renal
Risks, harm, cost Risk of inaccurate diagnosis. Unclear what norms or schedule should disease is a more common cause
be used. Few validated devices in children, and cuff sizes are limited of HTN in younger children.239
Benefit–harm assessment Benefits outweigh harm when used as an adjunctive measurement
Renal disorders (including vascular
technique
Intentional vagueness None problems) accounted for 63% to 74%
Role of patient preferences Patients may find home BP more convenient and accessible than office of children <6 years of age who were
or ambulatory BP enrolled in 3 recent clinical trials
Exclusions None of angiotensin receptor blockers
Strength Moderate recommendation
– 244
(ARBs).239,242 No increased
Key references 159,221–225,227,230
frequency was seen in younger
patients in a recent single-center case
series, however.101 It is appropriate
systems of pediatric primary care, more common than secondary HTN to have a high index of suspicion
and these comments would not apply among American youth.238 for renal and renovascular disease
to them. in hypertensive pediatric patients,
General characteristics of children
particularly in those <6 years of age.
with primary HTN include older
5. Primary and Secondary Causes age (≥6 years),239,240
positive
family history (in a parent and/or 5.3 Secondary Causes: Cardiac,
of HTN Including Aortic Coarctation
grandparent) of HTN,236,237,
240 and
5.1 Primary HTN overweight and/or obesity.16,236,
237,
239
Coarctation of the aorta is a congenital
Severity of BP elevation has not abnormality of the aortic arch
Primary HTN is now the predominant differed significantly between characterized by discrete narrowing
diagnosis for hypertensive children children with primary and secondary of the aortic arch, generally at the
and adolescents seen in referral HTN in some studies,235,237
but level of the aortic isthmus. It is usually
centers in the United States,235,236
DBP elevation appears to be more associated with HTN and right arm
although single-center studies from predictive of secondary HTN,239,240
BP that is 20 mm Hg (or more)
outside the United States still find whereas systolic HTN appears to be greater than the lower extremity BP.
primary HTN to be uncommon.237 more predictive of primary Repair in infants is often surgical;
Although prospective, multicenter HTN.236,239 adolescents may be treated with
studies are generally lacking, at least angioplasty or stenting. Long-segment
one large study in which researchers
Key Action Statement 11 narrowing of the abdominal aorta
used insurance claims data confirmed Children and adolescents ≥6 years can also cause HTN and should be
that primary HTN is significantly of age do not require an extensive considered in children with refractory
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TABLE 14 Examples of Physical Examination Findings and History Suggestive of Secondary HTN or confirmed potential nephrotoxicity
Related to End Organ Damage Secondary to HTN of cadmium in children,304 no
Body System Finding, History Possible Etiology definite effect on BP has been
Vital signs Tachycardia Hyperthyroidism demonstrated.304,305
PCC
Neuroblastoma
•• Mercury: Mercury is a known
Decreased lower extremity pulses; drop Coarctation of the aorta nephrotoxin, particularly in its
in BP from upper to lower extremities elemental form.306,307 Severe
Eyes Proptosis Hyperthyroidism mercury intoxication has been
Retinal changesa Severe HTN, more likely to be associated linked to acute HTN in children
with secondary HTN
Ear, nose, throat Adenotonsillar hypertrophy SDB
in several case reports; patients’
History of snoring Sleep apnea symptoms may resemble
Height, weight Growth retardation Chronic renal failure those seen in patients with
Obesity (high BMI) Cushing syndrome pheochromocytoma (PCC).308–310
Truncal obesity Insulin resistance syndrome
Head, neck Elfin facies Williams syndrome •• Phthalates: Antenatal and
Moon facies Cushing syndrome childhood exposure to phthalates
Thyromegaly, goiter Hyperthyroidism
has recently been associated
Webbed neck Turner syndrome
Skin Pallor, flushing, diaphoresis PCC with higher childhood BP311– 313
Acne, hirsutism, striae Cushing syndrome but not with the development of
Anabolic steroid abuse overt HTN. Specific metabolites of
Café-au-lait spots Neurofibromatosis these ubiquitous chemicals may
Adenoma sebaceum Tuberous sclerosis
have differential effects on BP,313
Malar rash Systemic lupus
Acanthosis nigricans T2DM indicating that much more detailed
Hematologic Pallor Renal disease study is needed to completely
Sickle cell anemia understand the effect of such
Chest, cardiac Chest pain Heart disease exposure.
Palpitations
Exertional dyspnea
Widely spaced nipples Turner syndrome 5.6 Secondary Causes:
Heart murmur Coarctation of the aorta Neurofibromatosis
Friction rub Systemic lupus (pericarditis)
Collagen vascular disease
Neurofibromatosis type 1 (NF-1)
Apical heavea LVH (also known as Von Recklinghausen
Abdomen Abdominal mass Wilms tumor disease) is a rare autosomal
Neuroblastoma dominant disorder characterized by
PCC distinct clinical examination findings.
Epigastric, flank bruit RAS
Palpable kidneys Polycystic kidney disease
These include the following: cafe-
Hydronephrosis au-lait macules, neurofibromas,
Multicystic dysplastic kidney Lisch nodules of the iris, axillary
Genitourinary Ambiguous or virilized genitalia Congenital adrenal hyperplasia freckling, optic nerve gliomas, and
Urinary tract infection Renal disease distinctive bone lesions. Patients
Vesicoureteral reflux
Hematuria, edema, fatigue
with NF-1 have several unique and
Abdominal trauma potential secondary causes of HTN,
Extremities Joint swelling Systemic lupus most commonly renal artery stenosis
Collagen vascular disease (RAS); coarctation of the aorta,
Muscle weakness Hyperaldosteronism
middle aortic syndrome, and PCC are
Liddle syndrome
Neurologic, Hypokalemia, headache, dizziness, Reninoma also well described.314– 319
metabolic polyuria, nocturia
Additionally, an increased incidence
Muscle weakness, hypokalemia Monogenic HTN (Liddle syndrome, GRA,
AME) of idiopathic HTN has been
AME, apparent mineralocorticoid excess; GRA, glucocorticoid-remediable aldosteronism. Adapted from Flynn JT. Evaluation
documented in patients with NF-1,
and management of hypertension in childhood. Prog Pediatr Cardiol. 2001;12(2):177–188; National High Blood Pressure as high as 6.1% in a recent pediatric
Education Program Working Group on Hypertension Control in Children and Adolescents. The fourth report on the case series, which is a much greater
diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics. 2004;114(2):555–576.
a Findings that may be indicative of end organ damage related to HTN. incidence than in the general
population.320 PCC has also been
well described in patients with NF-1,
although exact incidences are difficult
Downloaded
Family history of primary aldosteronism
Resistant HTN
Congenital adrenal hyperplasia
11β–hydroxylase deficiency CYP11B1 (loss of function) AR HTN Elevated levels of DOC, 11-deoxycortisol, 257–259
androstenedione, testosterone, and DHEAS
Hypokalemia Higher prevalence in Moroccan Jews
Acne, hirsutism, and virilization in
girls
Pseudoprecocious puberty in boys
11% of congenital adrenal
hyperplasia
17-α hydroxylase deficiency CYP17 (loss of function) AR HTN and hypokalemia Elevated DOC and corticosterone 260–262
Low aldosterone and renin Decreased androstenedione, testosterone and DHEAS
Undervirilized boys, sexual infantilism Prominent in Dutch Mennonites
in girls
<1% of congenital adrenal
hyperplasia
Familial hyperaldosteronism
Type 1 Hybrid CYP11B1 and CYP11B2 AD Young subjects with PA Excessive, ACTH-regulated aldosterone production 263,264
(11β-hydroxylase– Family history of young strokes Prescription with low-dose dexamethasone
aldosterone synthase, gain May add low-dose spironolactone, calcium channel
of function) blocker, or potassium supplementation
Type 2 Unknown, possibly 7p22 AD (prevalence varies PA in the patient with an affected Excessive autonomous aldosterone production 265–267
27
28
TABLE 15 Continued
Name of Disorder Genetic Mutation Mode of Inheritance Clinical Feature(s) Biochemical Mechanism and Notes Ref No(s).
Carney complex PRKAR1A AD Skin pigmentation Rare familial cause 273,274
Pituitary and other tumors
McCune Albright syndrome GNAS, α-subunit Somatic Cutaneous pigmentation Tumors in the breast, thyroid, pituitary gland, or 275,276
Fibrous dysplasia testicles may be present
Primary glucocorticoid NR3C1 (loss of function AD HTN Loss of function of glucocorticoid receptor 277–279
resistance (Chrousos glucocorticoid receptor) Ambiguous genitalia
syndrome) Precocious puberty
Androgen excess, menstrual
abnormalities or infertility in
women
Apparent mineralocorticoid HSD11B2 (loss of function) AR HTN Reduced or absent activity of 11 β-HSD2: cortisol 280,281
excess gains access to MR
Hypokalemia Mimicked by licorice toxicity
Low birth weight
Failure to thrive
Polyuria, polydipsia
Liddle syndrome SCNN1B β-subunit–SCNN1G Severe HTN Constitutive activation of the epithelial sodium 282,283
γ-subunit (activating Hypokalemia channel causing salt retention and volume
mutation) Metabolic alkalosis expansion
Muscle weakness
Geller syndrome MCR (mineralocorticoid-d AD Onset of HTN <20 y Constitutive activation of MR 284
receptor, activating Exacerbated by pregnancy Also activated by progesterone
mutation)
Pseudohypo-aldosteronism WNK1,4; KLHL3; CUL3; SPAK AD Short stature Increased activity of sodium chloride cotransporter 285–287
type 2 (Gordon syndrome) (activating mutation) Hyperkalemic and hyperchloremic causing salt retention and volume expansion
metabolic acidosis
Borderline HTN
Glucocorticoid excess
Cushing syndrome, To be discovered — HTN Likely attributable to increased DOC, sensitivity to 288–290
adrenocortical Other signs of Cushing syndrome vasoconstriction, cardiac output, activation of RAS
carcinoma, iatrogenic
excess
Other endocrine abnormalities
Hyperthyroidism To be discovered — Tachycardia Mechanism increased cardiac output, stroke volume, 291,292
and decreased peripheral resistance
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the same effect is seen in younger 6.2e Family History physical examination findings. The
children.333 One study found that high physical examination in hypertensive
Taking and updating the family
intake of total fat and saturated fat, as children is frequently normal except
history is a quick and easy way
well as adiposity and central obesity, for the BP elevation.
to risk-stratify pediatric patients
were also predictors of SBP.334– 336
with an increased risk for HTN. It
Nutrition history is an important
Key Action Statement 13
is important to update the family
part of the patient assessment history for HTN over the course of In children and adolescents being
because it may identify dietary the pediatric patient’s lifetime in the evaluated for high BP, the provider
contributors to HTN and detect practice (typically until 18–21 years should obtain a perinatal history,
areas in which lifestyle modification of age) because first- and second- appropriate nutritional history,
may be appropriate. The important degree relatives may develop HTN physical activity history, psychosocial
components to discuss include salt during this time. All too often, the history, and family history and
intake (including salt added in the diagnosis of HTN in the pediatric perform a physical examination
kitchen and at the table and sodium patient stimulates the collection of to identify findings suggestive of
hidden in processed and fast food), a detailed family history of HTN, secondary causes of HTN (grade B,
consumption of high-fat foods, and sometimes even years after the strong recommendation).
consumption of sugary beverages.337,338
pediatric patient has had elevated BP,
Infrequent consumption of fruits, instead of the other way around.352 6.4 Laboratory Evaluation
vegetables, and low-fat dairy
products should also be identified. 6.3 Physical Examination The purpose of the laboratory
A complete physical examination may evaluation is to identify underlying
6.2c Physical Activity History
provide clues to potential secondary secondary causes of HTN (eg, renal
A detailed history of physical causes of HTN and assess possible or endocrine disease) that would
activity and inactivity is an integral hypertensive end organ damage. The require specific treatment guided by a
part of the patient assessment, not child’s height, weight, calculated BMI, subspecialist. In general, such testing
only to understand contributors and percentiles for age should be includes a basic set of screening tests
to the development of HTN but determined at the start of the physical and additional, specific tests; the
also to direct lifestyle modification examination. Poor growth may latter are selected on the basis of clues
counseling as an important part of indicate an underlying chronic illness. obtained from the history and physical
management.339– 344
examination and/or the results of the
At the second visit with confirmed initial screening tests.354 Table 10
6.2d Psychosocial History elevated BP or stage 1 HTN or the provides a list of screening tests and
first visit with confirmed stage 2 the populations in which they should
Providers should obtain a HTN, BP should be measured in both be performed.
psychosocial history in children arms and in a leg. Normally, BP is
and adolescents with suspected or 10 to 20 mm Hg higher in the legs 6.5 Electrocardiography
confirmed HTN. Adverse experiences than the arms. If the leg BP is lower
both prenatally345 and during Approximately one-half of
than the arm BP, or if femoral pulses
childhood (including maltreatment, adolescents with HTN have
are weak or absent, coarctation of
early onset depression, and anxiety) undergone electrocardiography
the aorta may be present. Obesity
are associated with adult-onset at least once as an assessment for
alone is an insufficient explanation
HTN.346,347
The identification of stress LVH.355 Unlike echocardiography,
for diminished femoral pulses in the
may suggest a diagnosis of WCH. electrocardiography takes little
presence of high BP.
The psychosocial history should time and is a relatively low-cost
include questions about feelings of The remainder of the physical test. Electrocardiography has high
depression and anxiety, bullying, examination should pursue clues specificity but poor sensitivity
and body perceptions. The latter is found in the history and should focus for identifying children and
particularly important for patients on body systems and findings that adolescents with LVH.356– 358
with overweight or obesity because may indicate secondary HTN and/ The positive predictive value of
∼70% of these children report or end organ damage related to HTN. electrocardiography to identify LVH
having bullying and body perception Table 14 lists important physical is extremely low.359
concerns.348 Starting at 11 years of examination findings in hypertensive
age, the psychosocial history should children.353 These are examples of Key Action Statement 14
include questions about smoking,349,350
history and physical findings and do Clinicians should not perform
alcohol, and other drug use.351 not represent all possible history and electrocardiography in hypertensive
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95th percentile of a population- TABLE 16 DASH Diet Recommendations
based distribution and these Food Servings per Day
thresholds is uncertain372); Fruits and vegetables 4–5
Low-fat milk products ≥2
•• An LV relative wall thickness >0.42 Whole grains 6
cm indicates concentric geometry. Fish, poultry, and lean red meats ≤2
LV wall thickness >1.4 cm is Legumes and nuts 1
abnormal373; and Oils and fats 2–3
Added sugar and sweets (including sweetened beverages) ≤1
•• Decreased LV ejection fraction is a Dietary sodium <2300 mg per d
value <53%. Adapted from Barnes TL, Crandell JL, Bell RA, Mayer-Davis EJ, Dabelea D, Liese AD. Change in DASH diet score and
cardiovascular risk factors in youth with type 1 and type 2 diabetes mellitus: the SEARCH for Diabetes in Youth study.
Nutr Diabetes. 2013;3:e91; US Department of Health and Human Services, US Department of Agriculture. Appendix 7.
There are a number of additional Nutritional goals for age-sex groups based on dietary reference intakes and dietary guidelines recommendations. In: 2015-
evidence gaps related to the 2020 Dietary Guidelines for Americans. Washington, DC: US Department of Health and Human Services, US Department of
echocardiographic assessment of Agriculture; 2015; and Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and
Adolescents; National Heart, Lung, and Blood Institute. Expert Panel on Integrated Guidelines for Cardiovascular Health and
LV target organ injury. The value Risk Reduction in Children and Adolescents: Summary Report. Pediatrics. 2011;128 (suppl 5): S213–S256.
of LV mass assessment in risk
reclassification independent of 4. In patients without target organ injury (grade C,
conventional risk assessment has not LV target organ injury at moderate recommendation).
been established in adults.364 The initial echocardiographic
costs and benefits of incorporation 6.7 Vascular Structure and Function
assessment, repeat
of echocardiography into HTN echocardiography at yearly Emerging data demonstrate an
care has not been assessed. Quality intervals may be considered association of higher levels of BP
control regarding reproducibility of in those with stage 2 HTN, in youth with adverse changes in
measurements across laboratories may secondary HTN, or chronic measures of vascular structure and
be suboptimal.374 The most accurate stage 1 HTN incompletely function, including ultrasonography
method to measure LV mass (M-mode; treated (noncompliance or drug of the cIMT, PWV, a robust measure
two-dimensional; or, in the near resistance) to assess for the of central arterial stiffness66 that is
future, three-dimensional techniques) development of worsening LV related to hard CV events in adults
requires further research.
Key Action Statement 15 Key Action Statement 15. It is recommended that echocardiography be performed
to assess for cardiac target organ damage (LV mass, geometry, and function) at
1. It is recommended that the time of consideration of pharmacologic treatment of HTN;
echocardiography be performed LVH should be defined as LV mass >51 g/m2.7 (boys and girls) for children and
to assess for cardiac target organ adolescents older than 8 years and defined by LV mass >115 g/BSA for boys and
damage (LV mass, geometry, LV mass >95 g/BSA for girls;
and function) at the time of Repeat echocardiography may be performed to monitor improvement or
consideration of pharmacologic progression of target organ damage at 6- to 12-month intervals. Indications to
treatment of HTN; repeat echocardiography include persistent HTN despite treatment, concentric LV
2. LVH should be defined as LV mass hypertrophy, or reduced LV ejection fraction; and
>51 g/m2.7 (boys and girls) for In patients without LV target organ injury at initial echocardiographic
children and adolescents older assessment, repeat echocardiography at yearly intervals may be considered
than 8 years and defined by LV in those with stage 2 HTN, secondary HTN, or chronic stage 1 HTN incompletely
mass >115 g/BSA for boys and LV treated (noncompliance or drug resistance) to assess for the development of
mass >95 g/BSA for girls; worsening LV target organ injury (grade C, moderate recommendation).
Aggregate Evidence Quality Grade C
3. Repeat echocardiography Benefits Severe LV target organ damage can only be identified
may be performed to monitor with LV imaging. May improve risk stratification
improvement or progression Risks, harm, cost Adds cost; improvement in outcomes from incorporating
of target organ damage at 6- to echocardiography into clinical care is not established
Benefit–harm assessment Benefits exceed harms
12-month intervals. Indications to Intentional vagueness None
repeat echocardiography include Role of patient preferences Patients may elect to not to have the study
persistent HTN despite treatment, Exclusions None
concentric LV hypertrophy, or Strength Moderate recommendation
Key references 361,363,364,367–369
reduced LV ejection fraction; and
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34
TABLE 17 Dosing Recommendations for the Initial Prescription of Antihypertensive Drugs for Outpatient Management of Chronic HTN
Drug Age Initial Dose Maximal Dose Dosing Interval Formulations
ACE inhibitors
Contraindications: pregnancy, angioedema
Common adverse effects: cough, headache, dizziness, asthenia
Severe adverse effects: hyperkalemia, acute kidney injury, angioedema, fetal toxicity
Benazepril ≥6 ya 0.2 mg/kg per d (up to 10 mg per d) 0.6 mg/kg per d (up to 40 mg Daily Tablet: 5, 10, 20, 40 mg (generic)
per d) Extemporaneous liquid: 2 mg/mL
Captopril Infants 0.05 mg/kg per dose 6 mg/kg per d Daily to 4 times a day Tablet: 12.5, 25, 50, 100 mg (generic)
Children 0.5 mg/kg per dose 6 mg/kg per d Three times a day Extemporaneous liquid: 1 mg/mL
Enalapril ≥1 moa 0.08 mg/kg per d (up to 5 mg per d) 0.6 mg/kg per d (up to 40 mg Daily to twice a day Tablet: 2.5, 5, 10, 20 mg (generic)
per d) Solution: 1 mg/mL
Fosinopril ≥6 y 0.1 mg/kg per d (up to 5 mg per d) 40 mg per d Daily Tablet: 10, 20, 40 mg (generic)
<50 kg
≥50 kga 5 mg per d 40 mg per d
Lisinopril ≥6 ya 0.07 mg/kg per d (up to 5 mg per d) 0.6 mg/kg per d (up to 40 mg Daily Tablet: 2.5, 5, 10, 20, 30, 40 mg (generic)
per d) Solution: 1 mg/mL
Ramipril — 1.6 mg/m2 per d 6 mg/m2 per d Daily Capsule: 1.25, 2.5, 5 10 mg (generic)
Quinapril — 5 mg per d 80 mg per d Daily Tablet: 5, 10, 20, 40 mg (generic)
ARBs
Contraindications: pregnancy
Common adverse effects: headache, dizziness
Severe adverse effects: hyperkalemia, acute kidney injury, fetal toxicity
Candesartan 1–5 ya 0.02 mg/kg per d (up to 4 mg per d) 0.4 mg/kg per d (up to 16 mg Daily to twice a day Tablet: 4, 8, 16, 32 mg
per d)
≥6 ya Extemporaneous liquid: 1 mg/mL
<50 kg 4 mg per d 16 mg per d
≥50 kg 8 mg per d 32 mg per d
Irbesartan 6–12 y 75 mg per d 150 mg per d Daily Tablet: 75, 150, 300 mg (generic)
≥13 150 mg per d 300 mg per d
Losartan ≥6 ya 0.7 mg/kg (up to 50 mg) 1.4 mg/kg (up to 100 mg) Daily Tablet: 25, 50 100 (generic)
Extemporaneous liquid: 2.5 mg/mL
Olmesartan ≥6 ya — — Daily Tablet: 5, 20, 40 mg
<35 kg 10 mg 20 mg Extemporaneous liquid: 2 mg/mL
≥35 kg 20 mg 40 mg
Valsartan ≥6 ya 1.3 mg/kg (up to 40 mg) 2.7 mg/kg (up to 160 mg) Daily Tablet: 40, 80, 160, 320 mg (generic)
Extended-release tablet: 5, 10 mg
Extemporaneous liquid: 1 mg/mL imaging modalities for the
Formulations
identification of hemodynamically
significant vascular stenosis. One
study that included both pediatric
Tablet: 2.5, 5,10 mg
Capsule: 2.5, 5 mg
(generic)
sensitivity and specificity for the
detection of RAS was 94% and 93%
for CTA and 90% and 94% for MRA,
respectively.389
Unfortunately, studies of either
times a day; extended-
Capsule: twice daily to 3
Daily
by hemodynamically significant
0.05–0.1 mg/kg
Child
Child
≥6 y
Contraindications: hypersensitivity to CCBs
Age
Felodipine
Isradipine
adolescents.390
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Key Action Statement 17 also shown that lowering UA can Seeman et al411 did not control for
decrease BP levels, and increased UA these potential confounders.
In children and adolescents
levels blunt the efficacy of lifestyle
suspected of having RAS, either Limited, single-center data suggest
modifications on BP control.400– 404
CTA or MRA may be performed as a that a reduction in the degree of MA,
No large-scale, multicenter study has
noninvasive imaging study. Nuclear more than a reduction in BMI or
yet been conducted to confirm these
renography is less useful in pediatrics SBP, is associated with a decrease in
preliminary findings. Hence, there is
and should generally be avoided LVMI. In particular, researchers in
currently not sufficient evidence to
(grade D, weak recommendation). this single-center, nonrandomized,
support the routine measurement
prospective study of 64 hypertensive
6.9 Uric Acid of serum UA in the evaluation
children without kidney disease who
and management of children with
Cross-sectional data have suggested were 11 to 19 years of age evaluated
elevated BP.
a relationship between elevated the children at baseline and after
serum uric acid (UA) levels and HTN. 6.10 Microalbuminuria 12 months of combination ACE and
Two recent studies of adolescents hydrochlorothiazide (N = 59) or
included in NHANES 1999–2000 Microalbuminuria (MA), which ACE, hydrochlorothiazide, and ARB
and a small study conducted in Italy should be differentiated from therapy (N = 5). Results found that
found that elevated UA levels were proteinuria in CKD, has been shown lowering MA in children is associated
associated with higher BP.395– 397
to be a marker of HTN-related kidney with a regression of LVH.413 Given
In the Italian study and in another injury and a predictor of CVD in the single-center design and lack
US study of youth with obesity and adults.405– 408
MA has been shown to of a control group, however, the
HTN,397,398 elevated UA was also be effectively reduced via the use of applicability of these findings to the
associated with other markers of CV ARBs and ACE inhibitors in adults. general population of children with
risk. These findings suggest that the Lowering the degree of MA in adults primary HTN is unknown.
measurement of UA levels may best has been associated with decreased
CVD risk. Key Action Statement 18
be viewed as 1 component of CV risk
assessment, especially in those with In contrast, data to support a clear Routine testing for MA is not
obesity. relationship between HTN and MA recommended for children and
in pediatric patients with primary adolescents with primary HTN (grade
A causative role for elevated UA in HTN are limited.408– 410
A single, C, moderate recommendation).
the development of childhood HTN retrospective study of children with
has not been definitively established, primary HTN and WCH found that
although recent studies suggest that 20% of the former had MA versus 7. Treatment
it may be on the causal pathway. 0% of the latter.411 MA appears to
7.1 Overall Goals
A longitudinal study in which be a nonspecific finding in children
researchers followed a group of that can occur in the absence of HTN; The overall goals for the treatment
children for an average of 12 years it can occur in children who have of HTN in children and adolescents,
demonstrated that childhood UA obesity, insulin resistance, diabetes, including both primary and
levels were associated with adult dyslipidemia, and even in those secondary HTN, include achieving a
BP levels even after controlling who have recently participated in BP level that not only reduces the risk
for baseline BP.399 A few small, vigorous physical activity.412 The for target organ damage in childhood
single-center clinical trials have previously mentioned study by but also reduces the risk for HTN and
related CVD in adulthood. Several
Key Action Statement 17. In children and adolescents suspected of having RAS, studies have shown that currently
either CTA or MRA may be performed as a noninvasive imaging study. Nuclear
available treatment options can
renography is less useful in pediatrics and should generally be avoided (grade D,
even reverse target organ damage in
weak recommendation).
hypertensive youth.105,414,
415
Aggregate Evidence Quality Grade D
Benefits Avoidance of complications of an invasive procedure (angiography) The previous recommendations for
Risks, harm, cost Potential false-positive or false-negative results HTN treatment target in children
Benefit–harm assessment Potential for avoidance of an invasive procedure outweighs risk of
without CKD or diabetes were SBP
false-negative or false-positive results
Intentional vagueness None and DBP <95th percentile. Since that
Role of patient preferences None recommendation was made, evidence
Exclusions Children and adolescents without suspected RAS has emerged that markers of target
Strength Weak recommendation; pediatric data are limited organ damage, such as increased
Key references 389,390
LVMI, can be detected among some
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led to lower BP in some studies of TABLE 18 OSAS Symptoms and Signs
adolescents with elevated BP,426 History of frequent snoring (≥3 nights per week)
youth with overweight,427 girls with Labored breathing during sleep
metabolic syndrome,428 and youth Gasps, snorting noises, observed episodes of apnea
Sleep enuresis (especially secondary enuresis)
with T2DM.429 However, consuming
Sleeping in a seated position or with the neck hyperextended
a healthier diet may increase Cyanosis
costs.430 Headaches on awakening
Daytime sleepiness
7.2b Physical Activity Attention-deficit/hyperactivity disorder
Learning problems
Observational data support a Physical examination
relationship between physical Underweight or overweight
activity and lower BP, although the Tonsillar hypertrophy
Adenoidal facies
data are scant.339 Interventional Micrognathia, retrognathia
data demonstrate increasing High-arched palate
physical activity leads to lower BP. Failure to thrive
A review of 9 studies of physical HTN
activity interventions in children and Adapted from Marcus CL, Brooks LJ, Draper KA, et al; American Academy of Pediatrics. Diagnosis and management of
adolescents with obesity suggested childhood obstructive sleep apnea syndrome. Pediatrics. 2012;130(3). Available at: www.pediatrics.org/cgi/content/full/
130/3/e714.
that 40 minutes of moderate to
vigorous, aerobic physical activity at
week (30–60 minutes per session) combination with other behavioral
least 3 to 5 days per week improved
to help reduce BP (grade C, weak techniques to address overweight
SBP by an average of 6.6 mm Hg and
recommendation). and obesity in children.436 Studies
prevented vascular dysfunction.340
in hypertensive adults support the
A number of subsequent, additional 7.2c Weight Loss and Related CV Risk use of MI to improve adherence to
studies with small sample sizes Factors antihypertensive medications437 and
support a benefit of physical activity
As is true for children and decrease SBP.436 Although there are
on BP.341 A more recent analysis
adolescents with isolated HTN, no trials investigating the use of MI
of 12 randomized controlled trials
a DASH diet426,432
and vigorous in the care of hypertensive youth,
including 1266 subjects found
physical activity431 are recommended a number of studies have shown
reductions of 1% and 3% for resting
in pediatric patients with multiple that MI can be used successfully
SBP and DBP, respectively. These
obesity-related risk factors as part of to address or prevent childhood
results did not reach statistical
intensive weight-loss therapy.433,434 obesity by promoting physical
significance, however, and the
Motivational interviewing (MI) is a activity and dietary changes.438– 441
authors suggested that longer
tool recommended for pediatricians’ However, other studies have been
studies with larger sample sizes
use by the AAP Expert Committee less promising.442,443 In addition to
are needed.344 Any type of exercise,
Statement on Obesity.435 MI may the standard lifestyle approaches,
whether it’s aerobic training,
be a useful counseling tool to use in intensive weight-loss therapy
resistance training, or combined
training, appears to be beneficial342
(see “HTN and the Athlete”). Key Action Statement 20. At the time of diagnosis of elevated BP or HTN in a child
Programs that combine diet and or adolescent, clinicians should provide advice on the DASH diet and recommend
physical activity can have a beneficial moderate to vigorous physical activity at least 3 to 5 days per week (30–60
effect on SBP, as is shown in minutes per session) to help reduce BP (grade C, weak recommendation).
several studies designed to prevent Aggregate Evidence Quality Grade C
childhood obesity and address Benefits Potential to reduce BP
Risk, harm, cost No or low potential for harm. Following a healthier diet may increase
cardiometabolic risk.431 costs to patients and families
Benefit–harm assessment Potential benefit outweighs lack of harm and minimal cost
Key Action Statement 20 Intentional vagueness None
Role of patient preferences Level of caregiver and patient concern may influence adoption of the
At the time of diagnosis of elevated
DASH diet and physical activity. Patients may also have preferences
BP or HTN in a child or adolescent, around the use of a medication. These factors may influence the
clinicians should provide advice efficacy of lifestyle change
on the DASH diet and recommend Exclusions None
moderate to vigorous physical Strength Weak recommendation
Key references 332,339–342,424–431
activity at least 3 to 5 days per
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40
TABLE 19 Oral and Intravenous Antihypertensive Medications for Acute Severe HTN
Useful for Severely Hypertensive Patients With Life-Threatening Symptoms
Drug Class Dose Route Comments
Esmolol β-adrenergic blocker 100–500 μg/kg per min Intravenous infusion Short acting, constant infusion preferred. May cause
profound bradycardia
Hydralazine Direct vasodilator 0.1–0.2 mg/kg per dose up to 0.4 mg/kg Intravenous, intramuscular Causes tachycardia
per dose Give every 4 h when given intravenous bolus
Labetalol α- and β-adrenergic blocker Bolus: 0.20–1.0 mg/kg per dose up to 40 mg Intravenous bolus or infusion Asthma and overt heart failure are relative
per dose contraindications
Infusion: 0.25–3.0 mg/kg per h
Nicardipine Calcium channel blocker Bolus: 30 μg/kg up to 2 mg per dose Intravenous bolus or infusion May cause reflex tachycardia. Increases cyclosporine and
Infusion: 0.5–4 μg/kg per min tacrolimus levels
Sodium nitroprusside Direct vasodilator Starting: 0–3 μg/kg per min Intravenous infusion Monitor cyanide levels with prolonged (>72 h) use or in
Maximum: 10 μg/kg per min renal failure; or coadminister with sodium thiosulfate
Useful for Severely Hypertensive Patients With Less Significant Symptoms
Clonidine Central α-agonist 2–5 Μg/kg per dose up to 10 Μg/kg per Oral Adverse effects include dry mouth and drowsiness
dose given every 6–8 h
Fenoldopam Dopamine receptor agonist 0.2–0.5 Μg/kg per min up to 0.8 Μg/kg Intravenous infusion Higher doses worsen tachycardia without further reducing
per min BP
Hydralazine Direct vasodilator 0.25 mg/kg per dose up to 25 mg per dose Oral Half-life varies with genetically determined acetylation
given every 6–8 h rates
Isradipine Calcium channel blocker 0.05–0.1 mg/kg per dose up to 5 mg per Oral Exaggerated decrease in BP can be seen in patients
dose given every 6–8 h receiving azole antifungal agents
Minoxidil Direct vasodilator 0.1–0.2 mg/kg per dose up to 10 mg per Oral Most potent oral vasodilator, long acting
dose given Q 8–12 h
reassessed.
recommendation).
every 3 to 4 months.
BP measurement is frequently
of a second or third agent until
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8. Treatment in Special to intensive BP control (24-hour beneficial for preserving renal
Populations MAP <50th percentile by ABPM). function. Researchers in multiple
The study demonstrated fewer studies have evaluated the utility of
8.1 Treatment in Patients With CKD
composite CKD outcomes in children RAAS blockade therapy in patients
and Proteinuria
with the lower BP target.173 Recent 484– 487
with CKD and HTN.452,464,
465,
8.1a CKD adult data from the Systolic Blood These medications have been shown
Children and adolescents with Pressure Intervention Trial suggest to benefit both BP and proteinuria.
CKD often present with or develop lower BP targets may be beneficial
The benefit of such therapies may
HTN.478 HTN is a known risk factor in preventing other, adverse CV
not be sustained, however.173,488 The
for the progression of kidney disease outcomes as well.482
Effect of Strict Blood Pressure Control
in adults and children.173,479,
480 and ACE-Inhibition on Progression
Key Action Statement 23
Evidence suggests that the treatment of Chronic Renal Failure in Pediatric
of HTN in children with CKD might 1. Children and adolescents with Patients study demonstrated an
slow the progression of or reverse CKD should be evaluated for HTN initial 50% reduction in proteinuria
end organ damage.173,415
When at each medical encounter; in children with CKD after treatment
evaluated by 24-hour ABPM, children with ramipril but with a rebound effect
and adolescents with CKD often 2. Children or adolescents with both
CKD and HTN should be treated after 36 months.450,464,
488 This study
have poor BP control even if BP also showed that BP reduction with
measured in the clinic appears to be to lower 24-hour MAP to <50th
percentile by ABPM; and a ramipril-based antihypertensive
normal.48 MH is associated with end regimen improved renal outcomes.
organ damage, such as LVH.203,481 3. Regardless of apparent control of In children with HTN related to
Threshold values that define HTN are BP with office measures, children underlying CKD, the assessment of
not different in children with CKD, and adolescents with CKD and a proteinuria and institution of RAAS
although there is some evidence that history of HTN should have BP blockade therapy appears to have
lower treatment goals might improve assessed by ABPM at least yearly important prognostic implications.
outcomes. to screen for MH (grade B; strong
recommendation). Key Action Statement 24
In the European Effect of Strict Blood
Pressure Control and ACE-Inhibition Children and adolescents with
8.1b Proteinuria
on Progression of Chronic Renal CKD and HTN should be evaluated
Failure in Pediatric Patients study, Proteinuric renal disease is often for proteinuria (grade B, strong
researchers randomly assigned associated with HTN and a rapid recommendation).
children with CKD to standard decline in glomerular filtration.483
antihypertensive therapy (with Studies in both adults and children Key Action Statement 25
a treatment goal of 24-hour MAP have indicated that both BP control
Children and adolescents with CKD,
<90th percentile by ABPM) or and a reduction in proteinuria are
HTN, and proteinuria should be
treated with an ACE inhibitor or ARB
Key Action Statement 23. Children and adolescents with CKD should be evaluated (grade B, strong recommendation).
for HTN at each medical encounter;
Children or adolescents with both CKD and HTN should be treated to lower 24-hour 8.2. Treatment in Patients With
MAP to <50th percentile by ABPM; and Diabetes
Regardless of apparent control of BP with office measures, children and
Based on the Fourth Report criteria
adolescents with CKD and a history of HTN should have BP assessed by ABPM at
least yearly to screen for MH (grade B; strong recommendation). for the diagnosis of HTN,1 between
4% and 16% of children and
Aggregate Evidence Quality Grade B
Benefits Control of BP in children and adolescents with CKD has been shown adolescents with T1DM are found to
to decrease CKD progression and lead to resolution of LVH –491
have HTN.14,489 In the SEARCH
Risks, harm, cost Cost of ABPM and BP control, both financial and nonfinancial study of 3691 youth between the
Benefit–harm assessment Benefits of BP control in patients with CKD outweigh treatment risks ages of 3 and 17 years, elevated BP
Intentional vagueness Threshold
was documented in 6% of children
Role of patient preferences Patients may not want to wear the ambulatory BP monitor
repeatedly, which should lead to detailed counseling regarding the with T1DM, with the highest
benefits of this procedure in CKD prevalence in Asian Pacific Islander
Exclusions None and American Indian children
Strength Strong recommendation followed by African American and
Key references 47,173,203,415,480–483
Hispanic children and those with
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Key Action Statement 25. Children and adolescents with CKD, HTN, and proteinuria over the past decade by the
should be treated with an ACE inhibitor or ARB (grade B, strong recommendation). publication of several pediatric
Aggregate Evidence Quality Grade B clinical trials and case series of
Benefits ACE inhibitor and ARB therapy has been shown in the short-term to antihypertensive agents that can be
be effective in reducing urine proteinuria –530
used to treat such patients.465,523
Risks, harm, cost Positive effect on urine protein concentrations after the receipt of
an ACE inhibitor may not be sustained over time
Although children and adolescents
Benefit–harm assessment Treatment with an ACE inhibitor or ARB may lower the rate of
progression of renal disease even if the effect is not sustained in can become symptomatic from HTN
the long-term at lesser degrees of BP elevation,
Intentional vagueness Whether to aggressively treat the BP so that it is <90th percentile in general, patients who present
Role of patient preferences Patients may have concerns about the choice of medication, which with acute severe HTN will have BP
should be addressed
elevation well above the stage 2 HTN
Exclusions Children without CKD
Strength Strong recommendation threshold. In a study of 55 children
Key references 173,464,465,485,487,488 presenting to a pediatric ED in
Taiwan with hypertensive crisis, 96%
Key Action Statement 26. Children and adolescents with T1DM or T2DM should had SBP greater than that of stage
be evaluated for HTN at each medical encounter and treated if BP is ≥95th 2 HTN, and 76% had DBP greater
percentile or >130/80 mm Hg in adolescents ≥13 years of age (grade C, moderate than that of stage 2 HTN.531 The
recommendation). major clinical issue in such children
Aggregate Evidence Quality Grade C is that this level of BP elevation
Benefits Early detection and treatment of HTN in children with T1DM and may produce acute target organ
T2DM may reduce future CV and kidney disease effects, including encephalopathy,
Risks, harm, cost Risk of drug adverse effects and polypharmacy acute kidney injury, and congestive
Benefit–harm assessment Preponderance of benefit
heart failure. Clinicians should be
concerned about the development of
Intentional vagueness None
these complications when a child’s
Role of patient preferences Family concerns about additional testing and/or medication may
BP increases 30 mm Hg or more
need to be addressed
above the 95th percentile.
Exclusions None
Although a few children with primary
Strength Weak to moderate recommendation
HTN may present with features
Key references 14,110,111,494
of acute severe HTN,532 the vast
majority will have an underlying
secondary cause of HTN.532,533
10. Sex, Racial, and Ethnic in response to ACE inhibitors in the Thus, for patients who present with
Differences in BP and Medication pediatric age group,471 the strength acute severe HTN, an evaluation for
Choice of available evidence is insufficient to secondary causes is appropriate and
BP differences between various ethnic recommend using racial, sex, or ethnic should be conducted expediently.
groups are well described in the adult factors to inform the evaluation or Additionally, target organ effects
population.216,516
Large, cross-sectional management of HTN in children. should be assessed with renal
studies have demonstrated that, per function, echocardiography, and
capita, minority ethnic groups have central nervous system imaging,
both a higher prevalence of HTN and 11. Special Populations and among others.
more significant end organ damage Situations
and outcomes.517,518
Although a Given the potential for the
growing body of evidence indicates 11.1 Acute Severe HTN development of potentially life-
that racial and ethnic differences in BP threatening complications, expert
appear during adolescence,519– 521
the There is a lack of robust evidence opinion holds that children and
cause of these differences and when to guide the evaluation and adolescents who present with acute
they develop in childhood are yet to management of children and severe HTN require immediate
be fully determined. The risk of HTN adolescents with acute presentations treatment with short-acting
correlates more with obesity status of severe HTN. Thus, much of what antihypertensive medications that
than with ethnicity or race, although is known is derived from studies may abort such sequelae.533,534
there may be some interaction.216 At conducted in adults, including Treatment may be initiated with
this time, although limited data suggest medication choice.522 The evidence oral agents if the patient is able
that there may be a racial difference base has been enhanced somewhat to tolerate oral therapy and if
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Benefits
Clinical significance Baseline If HTN, treatment improves long- If HTN, treatment improves long- C WCH estimated at 35%,
term outcome term outcome ABPM results in fewer
false-positive screening
results
Cost of options
Visit, diagnosis costs (annual $1860 for visits and laboratory tests $1330 for visits, ABPM, and $1880 for visits, ABPM, and B —
estimated cost for 1 patient) laboratory tests laboratory tests
Costs from complications, adverse events, nonoptimal treatment
Likelihood of nonoptimal 60% undiagnosed patients; 35% of 30% undiagnosed patients All patients correctly diagnosed; C Assumes treatment
treatment those diagnosed with WCH fewer complications benefit for correctly
diagnosed HTN has no
complications
Costs of nonoptimal treatment Increased mortality for not treating Increased mortality for not treating All patients correctly diagnosed C —
undiagnosed HTN; inconvenience undiagnosed HTN who are treated
of treatment of patients with WCH
—, none.
45
and/or intense training presents It should be acknowledged that there transplants, the presence of native
a special circumstance. Existing are no data linking the presence kidneys, CKD, and transplant
guidelines present conflicting of HTN to sudden death related to glomerulopathy are additional risk
recommendations.1,538
Although sports participation in children, factors for HTN. HTN rates are higher
increased LV wall dimension may be although many cases of sudden death by 24-hour ABPM compared with
a consequence of athletic training,360 are of unknown etiology. That said, clinic BP measurements because these
recommendations from AHA and athletes identified as hypertensive populations commonly have MH and
ACC include the following: (1) limiting (eg, during preparticipation nocturnal HTN.179– 183,
542 Control
competitive athletic participation sports screening) should undergo of HTN in renal-transplant patients
among athletes with LVH beyond appropriate evaluation as outlined has been improved with the use of
that seen with athlete’s heart until above. For athletes with more severe annual ABPM.184,185
Therefore, ABPM
BP is normalized by appropriate HTN (stage 2 or greater), treatment should be used to identify and monitor
antihypertensive drug therapy, and should be initiated before sports nocturnal BP abnormalities and MH in
(2) restricting athletes with stage participation. pediatric kidney and heart-transplant
2 HTN (even among those without recipients. The use of home BP
evidence of target organ injury) from Key Action Statement 28 assessment may provide a comparable
participating in high-static sports Children and adolescents with HTN alternative to ABPM for BP assessment
(eg, weight lifting, boxing, and may participate in competitive after transplant as well.186
wrestling) until HTN is controlled sports once hypertensive target
The management of identified HTN
with either lifestyle modification or organ effects and risk have been
in the pediatric transplant patient
drug therapy.539 assessed (grade C, moderate
can be challenging. Rates of control
recommendation).
The AAP policy statement “Athletic of HTN in renal-transplant patients
Participation by Children and Key Action Statement 29 generally range from 33% to 55%.180,
Adolescents Who Have Systemic 187
In studies by Seeman et al,188
Children and adolescents with HTN
Hypertension” recommends that intensified antihypertensive
should receive treatment to lower
children with stage 2 HTN be treatment in pediatric renal-
BP below stage 2 thresholds before
restricted from high-static sports transplant recipients improved
participating in competitive sports
(classes IIIA to IIIC) in the absence nocturnal SBP and significantly
(grade C, weak recommendation).
of end organ damage, including LVH reduced proteinuria.543 Children
or concomitant heart disease, until in these studies who achieved
their BP is in the normal range after 11.3 HTN and the Posttransplant normotension had stable graft
lifestyle modification and/or drug Patient function, whereas those who
therapy.538 It is further recommended HTN is common in children after remained hypertensive at 2
that athletes be promptly referred solid-organ transplants, with years had a progression of renal
and evaluated by a qualified pediatric prevalence rates ranging from 50% disease.544
medical subspecialist within 1 week to 90%.179,180,
540,541
Contributing
Antihypertensive medications have
if they are asymptomatic or factors include the use of steroids,
rarely been systematically studied
immediately if they are symptomatic. calcineurin inhibitors, and mTOR
in this population. There is limited
The subcommittee agrees with these (mammalian target of rapamycin)
evidence that ACE inhibitors and ARBs
recommendations. inhibitors. In patients with renal
may be superior to other agents in
achieving BP control and improving
Key Action Statement 27. In children and adolescents with acute severe long-term graft survival in renal-
HTN and life-threatening symptoms, immediate treatment with short-acting transplant patients.185,543,544
However,
antihypertensive medication should be initiated, and BP should be reduced by the combination of ACE inhibitors
no more than 25% of the planned reduction over the first 8 hours (grade expert and ARBs in renal-transplant
opinion D, weak recommendation). patients has been associated with
Aggregate Evidence Quality Expert Opinion, D acidosis and hyperkalemia and is not
Benefits Avoidance of complications caused by rapid BP reduction recommended.545
Risks, harm, cost Severe BP elevation may persist
Benefit–harm assessment Benefit outweighs harm
Intentional vagueness None 12. Lifetime HTN Treatment and
Role of patient preferences None
Transition to Adulthood
Exclusions Patients without acute severe HTN and life-threatening symptoms
Strength Weak recommendation because of expert opinion For adolescents with HTN
Key references 240,533,535
requiring ongoing treatment, the
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Key Action Statement 30. Adolescents with elevated BP or HTN (whether they The third challenge is for
are receiving antihypertensive treatment) should typically have their care clinic personnel to be aware
transitioned to an appropriate adult care provider by 22 years of age (recognizing of what to do with high BP
that there may be individual cases in which this upper age limit is exceeded, measurements when they occur.
particularly in the case of youth with special health care needs). There should Knowing when to counsel patients,
be a transfer of information regarding HTN etiology and past manifestations and order tests or laboratory work,
complications of the patient’s HTN (grade X, strong recommendation).
and reach out for help is essential.
Aggregate Evidence Quality Grade X Making this part of standard
Benefits Provides continuity of care for patients
Risks, harm, cost None
practice so every child follows
Benefit–harm assessment No risk the prescribed pathway may be
Intentional vagueness None challenging.
Role of patient preferences Patient can pick adult care provider
Exclusions None The final diagnosis of HTN
Strength Strong recommendation
also relies on a number of
Key references 547
sequential visits. Ensuring that
patients return for all of these
visits and are not lost to follow-up
sedentary time, and possibly other and avoidance of tobacco products may require new clinic processes
dietary factors.551–553 are also reasonable strategies to or mechanisms. Information
reduce CV risk. technology may help remind
Because family history is immutable, providers to schedule these visits
it is difficult to build a preventive These preventive strategies can and remind patients to attend
strategy around it. However, a be implemented as part of routine these visits; even with that
positive family history of HTN primary health care for children and assistance, however, completing all
should suggest the need for closer adolescents. the visits may be difficult for some
BP monitoring to detect HTN if it patients.
occurs.
Appropriate energy balance with 14. Challenges in the In addition, family medicine
calories eaten balanced by calories Implementation of Pediatric HTN physicians and general
expended in physical activity is Guidelines pediatricians may face challenges
important. This is the best strategy in having normative pediatric
to maintain an appropriate BMI Many studies have shown that BP values available for use at all
percentile for age and sex and physicians fail to meet benchmarks times. Although adult BP cutoffs
to avoid the development of with respect to screening, especially are easy to memorize, pediatric
obesity.554 From a broader dietary universal screening for high BP in BP percentile cutoffs are greatly
perspective, a DASH-type diet (ie, children.7,115
Although the reasons dependent on age and height. The
high in fruits, vegetables, whole for this failure likely vary from BP tables in this guideline provide
grains, and low-fat dairy, with practice to practice, a number of cutoffs to use for the proper
decreased intake of foods high common challenges can be identified. diagnosis of HTN; their availability
in saturated fat or sugar) may be will simplify the recognition of
The first challenge is determining how abnormal BP values.
beneficial (see Table 16).423,427
to identify every child in a clinic who
Avoiding high-sodium foods may
merits a BP measurement. This could The AAP Education in Quality
prove helpful in preventing HTN,
be accomplished through flags in an Improvement for Pediatric Practice
particularly for individuals who are
EHR, documentation rules for specific module on HTN identification
more sensitive to dietary sodium
patients, and/or clinic protocols. and management556 and its
intake.555
The second challenge is establishing accompanying implementation
Adhering to recommendations a local clinic protocol for measuring guide557 should be of assistance to
for 60 minutes a day of moderate BP correctly on the basis of the practitioners who wish to improve
to vigorous physical activity can algorithms in this guideline. It their approach to identifying
be important to maintaining an is important to determine the and managing childhood HTN.
appropriate weight and may optimal approach on the basis of This module is currently being
be independently helpful to the available equipment, the skills updated to incorporate the new
maintaining a lower BP.344 The of clinic personnel, and the clinic’s recommendations in this
achievement of normal sleep habits throughput needs. guideline.
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is vital for physicians to provide Understanding the family and the types of clinical trials that
concise information in plain language patient’s perception of HTN and are needed to produce high-
and do so using a team approach. any underlying disease that may quality evidence. For example,
This will facilitate parents having a be contributing to it is important no large pediatric cohort has
clear understanding of the required to resolve any misconceptions ever been assembled to answer
tests, medications, follow-ups, and and encourage adherence to the the question of whether routine
outcomes. physician’s recommendations. To BP measurement in childhood is
attain therapeutic goals, proper useful to prevent adult CVD.566
education must be provided to the Given this, other types of evidence,
Patient Perspective, by Matthew family as a whole. This education such as from cross-sectional and
Goodwin should include proper medication observational cohort studies, must
dosages, recommended sodium be examined to guide practice.567
“I am not just a 13 year old, I am
intake, any dietary changes,
a teenager who has lived with
exercise expectations, and any From the standpoint of the primary
hypertension, renal disease, and
other behavioral changes. It is care provider, the most significant
midaortic syndrome since I was
equally important to stress to evidence gaps relate to whether
4 years old. I have experienced
the family the short- and long- diagnosing elevated BP and HTN in
surgeries, extended hospitalizations,
term effects of HTN if it is not children and adolescents truly has
daily medications, procedures,
properly managed. Parents with long-term health consequences,
tests, continued blood pressure
younger children will carry the whether antihypertensive
monitoring, lifestyle changes, and
ultimate burden of daily decisions medications should be used in a
dietary restrictions. Hypertension
as it applies to medications, food child or adolescent with elevated
is a part of my everyday life. It will
choices, and activity. Parents of BP, and what medications should be
always be a component of me. I had
older adolescents will partner with preferentially used. These evidence
to learn the effects of hypertension
the children to encourage the right gaps have been alluded to previously
at a young age. I knew what would
choices. Education as a family unit in this document.
happen to me if I ate too much
is important for everyone involved
salt or did not fully hydrate, thus I Other important evidence gaps
to understand the consequences.
became watchful. I did this so I could should be highlighted, including the
efficiently communicate with my following:
A family-based approach is important
physicians any changes I physically
for all pediatric diseases but plays a
felt or any symptoms that were new
or different regarding my illness.
particular role in conditions that are •• Is there a specific BP level in
substantially influenced by lifestyle childhood that predicts adverse
This has allowed me, my family, and
behaviors. This has been shown outcomes, and can a single number
my doctors to work effectively as
in several pediatric populations, (or numbers) be used to define
one unit. I am grateful for my doctors
including those with T2DM and HTN, as in adults?
listening to me as a person and not
obesity.561–565
as a kid.” •• Can and should ABPM ever replace
auscultation in the diagnosis of
childhood HTN?
Parents of children with 16. Evidence Gaps and Proposed •• Are the currently used, normative
hypertensive issues can encounter Future Directions standards for ABPM appropriate,
1 or more specialists in addition or are new normative data
to their pediatric clinician. This In general, the pediatric HTN needed?568
can prove to be overwhelming, literature is not as robust as the •• What is the best diagnostic
frightening, and may fill the parent adult HTN literature. The reasons evaluation to confidently exclude
with anxiety. Taking these things for this are many, but the 2 most secondary causes of HTN?
into account and creating unified important are as follows: (1)
partners, built with the physician the lower prevalence of HTN in •• Are other assessments of
and family, will encourage the childhood compared with adults, hypertensive target organ
family to be more involved in the and (2) the lack of adverse CV damage (such as urine MA or
patient’s health management. Plain events (myocardial infarction, vascular studies) better than
language in a team approach will stroke, and death) attributable echocardiography?
yield the most positive outcomes to HTN in young patients. These •• How confident can we be that a
for the patient. factors make it difficult to conduct child or teenager with elevated BP
PEDIATRICS Volume 140, number 3, September 2017 from http://pediatrics.aappublications.org/ by guest on April 29, 2018
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Seattle, Washington; nDepartment of Pediatrics, School of Medicine, Morehouse College, Atlanta, Georgia; oAssociate Director, General Academic Pediatric Fellowship, Staff Physician,
Boston's Children's Hospital Primary Care at Longwood, Instructor, Harvard Medical School, Boston, Massachusetts; Departments of pPediatrics and Internal Medicine, McGovern
Medical School, University of Texas, Houston, Texas; qPediatric Education, University of Pittsburgh Medical Center Shadyside Family Medicine Residency, Clinical Associate Professor of
Pediatrics, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, and School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; rDivision of Molecular
Genetics, Department of Pediatrics, Columbia University Medical Center, New York, New York; and sPreventive Cardiology, Cincinnati Children’s Hospital Medical Center, Department of
Pediatrics, University of Cincinnati, Cincinnati, Ohio
Drs Flynn and Kaelber served as the specialty and primary care chairs of the Subcommittee and had lead roles in developing the framework for the guidelines and coordinating
the overall guideline development; Dr Baker-Smith served as the epidemiologist and led the evidence review and synthesis; Ms. Flinn compiled the first draft of the manuscript and
coordinated manuscript revisions; All other authors were significantly involved in all aspects of the guideline creation including initial scoping, literature review and synthesis, draft
manuscript creation and manuscript review; and all authors approved the final manuscript as submitted.
This document is copyrighted and is property of the American Academy of Pediatrics and its Board of Directors. All authors have filed conflict of interest statements with the American
Academy of Pediatrics. Any conflicts have been resolved through a process approved by the Board of Directors. The American Academy of Pediatrics has neither solicited nor accepted
any commercial involvement in the development of the content of this publication.
The guidance in this report does not indicate an exclusive course of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be
appropriate.
All clinical practice guidelines from the American Academy of Pediatrics automatically expire 5 years after publication unless reaffirmed, revised, or retired at or before that time.
DOI: https://doi.org/10.1542/peds.2017-1904
FINANCIAL DISCLOSURE: The authors have indicated that they have no financial relationships relevant to this article to disclose.
FUNDING: The American Academy of Pediatrics provided funding to cover travel costs for subcommittee members to attend subcommittee meetings, to pay for the epidemiologist (Dr
Baker-Smith) and consultant (Susan Flynn), and to produce the revised normative blood pressure tables.
POTENTIAL CONFLICT OF INTEREST: The authors have indicated that they have no potential conflicts of interest to disclose.
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Pediatrics is the official journal of the American Academy of Pediatrics. A monthly publication, it
has been published continuously since . Pediatrics is owned, published, and trademarked by the
American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois,
60007. Copyright © 2017 by the American Academy of Pediatrics. All rights reserved. Print ISSN:
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Pediatrics is the official journal of the American Academy of Pediatrics. A monthly publication, it
has been published continuously since . Pediatrics is owned, published, and trademarked by the
American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois,
60007. Copyright © 2017 by the American Academy of Pediatrics. All rights reserved. Print ISSN:
.
E R R ATA Flynn JT, Kaelber DC, Baker-Smith CM, et al; SUBCOMMITTEE ON SCREENING
AND MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN. Clinical Practice
Guideline for Screening and Management of High Blood Pressure in Children
and Adolescents. Pediatrics. 2017; 140(3):e20171904
Errors occurred in the American Academy of Pediatrics “Clinical Practice Guideline
for Screening and Management of High Blood Pressure in Children and Adoles-
cents” (Pediatrics 2017;140(3):e20171904; http://pediatrics.aappublications.org/
content/140/3/e20171904). In Table 19, the dosage for Clonidine should have read
2–5 mcg/kg per dose up to 10 mcg/kg per dose given every 6–8 h, and the dosage
for Fenoldopam should have read 0.2–0.5 mcg/kg per min up to 0.8 mcg/kg per min.
To avoid confusion, the Greek letters “m” and its capital “M” have been removed and
“mcg” (micrograms) is used in all instances in the table. The electronic versions of the
article have been corrected.
doi:10.1542/peds.2017-3035
The online version of this article, along with updated information and services, is
located on the World Wide Web at:
http://pediatrics.aappublications.org/content/early/2017/08/21/peds.2017-1904
An erratum has been published regarding this article. Please see the attached page for:
http://pediatrics.aappublications.org//content/140/6/e20173035.full.pdf
Pediatrics is the official journal of the American Academy of Pediatrics. A monthly publication, it
has been published continuously since . Pediatrics is owned, published, and trademarked by the
American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois,
60007. Copyright © 2017 by the American Academy of Pediatrics. All rights reserved. Print ISSN:
.