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9 Huntress 1934 Method of Synthesis
9 Huntress 1934 Method of Synthesis
PHTHALHYDRAZIDE ("LUMINOL")
as a LECTURE DEMONSTRATION
of CHEMILUMINESCENCE*
ERNEST H. HUNTRESS, LESTER N. STANLEY, AND ALMON S. PARKER
Attention is directed to the most striking instance of compound^,^ notably (1) pchlorophenylmagnesium
chemiluminescence whuh appears to have b m observed bromide; (2) the Trautz-Schorigin6 oxidation of pyro-
and to the extraordinary advantages which the reaction gallol-formalin solutions in potassium carbonate by
possesses mer the conventional cases. A simple eco- means of 30% hydrogen peroxide (perbydrol); (3)
nomical two-stage synthesis of 3-aminophthulhydrazide is the oxidation%y means of hydrogen peroxide or halo-
described which readily gives excellent yields of +re gens of alcoholic alkaline solutions of lophine (2,4,5-tri-
product. Specifcc directions are given for demonstration phenylimidawle) or amarine (4,5-dihydro-2,4,5-tri-
of its brilliant chemiluminescence i n dilute aqueous al- phenylimidazole). It will readily be noted that even
kaline oxidizing agents. these reactions involve certain difficulties. For ex-
ample, some of the materials are unpleasant to handle
(e. g., chloropicrin is a lachrymator, Grignard reagents
are unstable and involve the use of ether solutions, 30%