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Hyun Kwon Ha1 OBJECTIVE. The purpose of this study was to determine the potential of CT for distin-
Jung rnJung2 guishing tuberculous peritonitis from peritoneal carcinomatosis in I 35 clinically or patholog-
Moo Song Lee3 ically proven cases.
Byung GilChoi2 MATERIALS AND METHODS. Abdominal CT scans in 135 patients of tuberculous
Moon-Gyu Lee1 peritonitis (ii = 42) and peritoneal carcinomatosis (ii = 93) with documented omental, mesen-
Young Hwan Kim1 teric. or peritoneal pathology were retrospectively reviewed. CT findings were evaluated in
Pyo Nyun Kim1 each group of patients for the morphologic appearance of mesenteric or omental abnormali-
Yong HoAuh1 ties as well as for visualization of the spleen and liver. the lymph nodes, and ascites. Statisti-
cal comparisons using multivariate logistic regression analysis were performed to adjust for
the differences in CT findings between the two groups.
RESULTS. Mesenteric changes were more commonly seen in patients with tuberculous
peritonitis (98%) than in patients with peritoneal carcinomatosis (70%) (p < .01). Micronod-
ules (less than 5 mm in diameter) were noted in approximately one halfofpatients with tuber-
culous peritonitis or peritoneal carcinomatosis. but macronodules (5 mm in diameter) were
much more frequently seen in patients with tuberculous peritonitis (52%) than in patients
with peritoneal carcinomatosis (12%) (p < . 01). The omentum appeared to be more irregu-
larly infiltrated in peritoneal carcinomatosis patients (p < .01 ). The thin omental line covering
the infiltrated omentum was seen in 13 patients with tuberculous peritonitis but in only four
patients with peritoneal carcinomatosis (p < .01 ). In peritoneal or extraperitoneal masses in
patients with tuberculous peritonitis. a low-density center was seen in I 8 cases (43%) and cal-
cification was noted in six cases ( 14%). The prevalences of splenomegaly and splenic calcifi-
cation were higher in patients with tuberculous peritonitis. Using multivariate analysis, we
calculated the sensitivity of CT for predicting tuberculous peritonitis and peritoneal carcino-
matosis as 69% and 9 1%, respectively.
CONCLUSION. Although most CT findings that we analyzed overlap these diseases,
using a combination of CT findings increased our ability to distinguish tuberculous peritonitis
from peritoneal carcinomatosis.
T ubereulou.s
reduced
infection
in incidence
has been
but still remains
greatly matosis
overlap
is difficult
of imaging
or impossible
findings.
because
However,
of an
until
a persistent problem in endemic recently many researchers have described van-
Received April 21, 1995; accepted after revision April 8, 1996. areas or in immunocompromised patients. ous CT findings separately for each disease
1 Department of Radiology, Asan Medical Center, University Although in many instances tuberculous perito- entity [2-61. and compansn studies of both
of Ulsan Medical College, 388-1 Poongnap-Dong Sonpa-Ku, nitis can be diagnosed clinically and radiologi- diseases are limited. If a clear separation
Seoul 138-040, Korea. Address correspondence to H. K. Ha.
cally. a difficulty is encountered in patients between these diseases can be made. invasive
2Department of Radiology, St. Mary’s Hospital, Catholic who lack typical symptoms and laboratory data studies, such as peritoneoscopy or exploratory
University Medical College, Seoul 137-701, Korea.
or whose chest films are normal, thus often laparotomy, might no longer be needed to con-
3Department of Preventive Medicine, University of Ulsan
mimicking peritoneal carcinomatosis I I 1. If firm the diagnosis. The purpose of this study
Medical College, Seoul 138-040, Korea.
there is diffuse infiltration of the peritoneum. was to determine the potential of CT for distin-
AJR 1996;167:743-748
omentum, or mesentery with no suggestion of guishing tuberculous peritonitis from perito-
0361-803X19611673-743 primary tumor on CT, distinguishing between neal carcinomatosis in 135 clinically or
© American Roentgen Ray Society tuberculous peritonitis and peritoneal carcino- pathologically proven cases.
Materials and Methods undetermined origin. Penitoneal carcinomatosis or its main branches. Splenoniegaly was defined as
In reviewing the medical records of patients was confirmed by laparotomy or laparoscopy (a = a spleen equal to or greater than 13 cm 71. The
who presented with tuberculous peritonitis 42) and paracentesis or aspiration biopsy (,i = 51). assessment of these findings was binary. and we did
between March 1991 and February 1994, we At surgery, widespread implantation of miliary not attempt to quantify the severity.
selected for analysis 42 patients who showed defi- tumor nodules was frequently found covering the Statistical qualitative and quantitative differ-
nite ornental, mesentenic. or penitoneal changes on serosal surfaces of the viscera. Paracentesis often ences in CT findings between the two groups were
CT scans and whose diagnoses were pathologically yielded a straw-colored or bloody fluid. analyied using Fisher’s exact test. Then, using a
or clinically proved as tuberculous peritonitis. Dur- CT was performed on commercially available software prograni (SAS Institute. Cary, NC). we
ing the same period. we also collected records of equipment (Somatom Plus-S: Siemens, Erland, performed a multivariate logistic regression analy-
93 consecutive patients with pathologically proven Germany, or GE Quick System; General Electric, sis 181 to determine which paranieters were useful
penitoneal carcinornatosis and obvious peritoneal Milwaukee, WI) using five, eight, or 10 slices at 8-, for distinguishing tuberculous peritonitis froni
disease on CT. No cases had both tuberculous pen- 10-, or 15-mm intervals from the dome of the dia- penitoneal carcinomatosis. Thereafter. the proba-
tonitis and pentoneal carcinornatosis concurrently. phragm to the symphysis pubis. The patients rou- bility of tuberculous peritonitis could be calculated
Clinical charts and surgical or pathologic findings tinely received oral and IV contrast material. The for each patient. With these data, the accuracy of
were also reviewed for each case. IV contrast medium, iopamidol (lopamiro 300; CT for predicting tuherculous peritonitis or perito-
The 42 patients with tuberculous peritonitis Bracco. Milano, Italy), was administered as a beilus neal carcinomatosis was obtained.
were between 8 and 74 years old (mean, 37 years followed by rapid drip infusion. CT scans of both
old); I 8 were men, and 24 were women. Of these groups were reviewed independently by two expeni-
patients. 14 were confirmed to have gastrointesti- enced radiologists; these observers were unaware of Results
nal tract involvement. and 29 had pulmonary the final diagnosis. CT scans in both groups were Mesentery
tuberculosis. No patients had a history of IV drug evaluated in random order. When interpretations
abuse or AIDS. The diagnoses were established by differed, a third radiologist reviewed the cases and The most conimon niesenteric changes
pathologic analyses obtained from laparotomy. majority opinion was used for a final decision. CT noted on CT included micronodular or macro-
laparoscopy. or fine-needle aspiration biopsy (ii = findings were compared for the morphologic nodular lesions, thickening of the mesentenic
30) or by improvement seen on abdominal CT appearance of mesenteric or omental abnormalities leaves (Fig. I ). and loss of normal mesentenic
studies following prescribed antituberculous che- as well as for visualization of the spleen and liver, configuration in both diseases. These mesen-
rnotherapy (a = 12). Of these 42 patients, 27 had the lymph nodes, and ascites. Mesentenic nodules tenic abnormalities were niore frequently seen
the wet form and I 5 had the dry form of tubercu- were divided into micronodular (less than 5 mm)
in patients with tuberculous peritonitis (98Ck)
bus peritonitis. In the patients who underwent sur- and macronodular (5 mm) forms, and loss of the
than in those with penitoneal carcinomatosis
gery. the wet form was associated with ascites of a normal configuration of the mesentery was mdi-
(70%) (/) < .01 ) (Table I).
yellowish turbid color, whereas the dry form cated when the mesentery showed an admixture of
soft-tissue densities, fluid densities, bowel
Micronodules (Fig. 2 were noted in 52% of
showed firmly matted intestine covered by a and
fibninous exudate. Also, visceral and panietal peri- loops. Omental pathology was divided into nodular patients with tuberculous peritonitis or penito-
toneal surfaces became studded with rniliary (presence of nodular masses). smudged (infiltration neal carcinomatosis (Table 2), whereas macro-
tubercles. The omenturn, which was usually in- with ill-defined lesions), or caked (soft-tissue nodules were seen in 22 (52C/ ) of the tubercu-
volved, was greatly thickened. Pathologic diagno- replacement) forms based on morphologic appear- bus peritonitis patients and I I ( I 2C/ ) of the
sis was made by observing caseating necrosis on ance. The omentum was considered to be smoothly penitoneal carcinoriiatosis patients (p < .01 ). For
the specimen and by culturing Mvcobacteriu,n thickened when the infiltrated omentum had a tumors that showed macronodules in penitoneal
tubereulo.s’is from the ascitic fluid or lymph nodes smooth border or showed a smooth transition from carcinomatosis patients. the origin was the
or by penitoneal biopsy. thick to thin portions; the omentum was considered
stomach in five, the rectum in one, the bile duct
The 93 patients with penitoneal carcinomatosis irregularly thickened when showing an irregular
in one, the uterus in one. the ovary in one, the
were between 19 and 89 years old (mean, 51 years border. The attenuation of the a.scites was compared
breast in one. and the lung in one. The macro-
old); 49 were men. and 44 were women. Patho- with fluid density of the gallbladder. renal cyst. or
logic proof of the primary tumor was available in bowel if not opacified with oral contrast agent. Loc- nodules seen in 22 of the tuberculous peritonitis
all cases; tumor origins were ovary in 31 patients, ulated ascites was defined as a localized, often patients had low-density centers in I 5 patients
stomach in 29, colon in eight, bile duct in five, round or oval fluid collection with mass effect. (Fig. 3). uniformly sized lesions in I 3 patients.
pancreas in five. uterus in three. liver in two, small Lymphadenopathy at unusual sites meant lymphad- and calcification in three patients.
intestine in two, and breast in two; six were of enopathy that did not follow the course of the aorta
Fig. 1.-Tuberculous peritonitis in 62-year-old wom- Fig. 2.-Peritoneal carcinomatosis due to cholangiocar- Fig. 3.-Tuberculous peritonitis in 24-year-old wom-
an. Contrast-enhanced CT scan shows thin lines cinoma in 43-year-old man. Contrast-enhanced CT scan an. Contrast-enhanced CT scan shows macronodular
(arrows) along course of mesenteric vessels, repre- shows micronodular type of peritoneal tumor seeding type of masses (ml with low-density centers and
senting thickened mesenteric leaves. (arrows) and nodular implants (arrowheads) on parietal thickened peripheral wall. Also note tiny calcifications
peritoneum. Note large amount of ascites present. (arrows) in some masses.
Omentum dial region (Fig. 8); two of the nine patients. in Ascites
Omental abnormalities were noted in 26 the paravertebral region; and the remaining two Ascites was present in 27 patients with tuber-
patients (62%) with tuberculous peritonitis and patients. in the iliopsoas compartment. All 10 culous peritonitis (64%) and in 78 patients with
in 80 patients (86%) with peritoneal carcinoma- patients with peritoneal carcinomatosis had petitoneal carcinomatosis(M%)(p < .05) (Table
tosis (p < .01) (Table 3). Smudged omentum involvement of the pericardial nodes. No 6). The distribution patterns and the attenuation
was the most common pattern of infiltration in patients with paravertebral or iliopsoas nodal ofthe ascites did not significantly differ between
both groups, although omental cake (Figs. 4 and involvement exhibited concomitant spinal in- the two groups (Fig. 9). However, fluid accumu-
5) was more common in patients with pento- volvement. In addition, calcifications within lation in the lesser sac occurred more frequently
neal carcinomatosis. The omentum was more enlarged lymph nodes were seen in five patients in the patients with pentoneal carcinomatosis (p
irregular (78% versus 19%) (p < .01) and with tuberculous peritonitis. < .05), but this finding is ofquestionable signifi-
thicker (2.6 cm versus I .7 cm) in patients with cance because the amount of ascites in the
Liver and Spleen patients with tuberculous peritonitis was less
pentoneal carcinomatosis than in patients with
tuberculous peritonitis. In addition, we found Thirteen of the 42 patients with tubercu- than the amount in patients with pentoneal carci-
that the thin fibrous wall (omental line) (Fig. 6) bus peritonitis (3 1%) showed splenic ab- nomatosis (p < .05).
Lymph Node
. . Tuberculous Peritonitis Peritoneal Carcinomatosis
Finding (n 42)
=
(n = 93) p
Peripancteatic lymph node involvement along
Omental changesa 62% (26/42) 86% (80/93) <.01
the branches of the celiac axis (Fig. 7) was seen
in 18 patients with tuberculous peritonitis Nodular 0% (0/26) 13% (10/80) NS
(43%) (Table 4); the degree of lymphadenopa- Smudged 92% (24/26) 68% (54/80) <.05
thy was minimal in nine patients and severe in Caked 8% (2/26) 20% (16/80) NS
the remaining nine, and two of the nine patients Thickness 1.7 cmb 2.6 cmb
with severe involvementdeveloped mild biliaty Smooth 81% (21/26) 20% (16/80) <.01
tree dilatation. We found no statistically signifi- Irregular 19% (5/26) 78% (62/80) <.01
cant differences between the two groups in the Omental line (+) 50% (13/26) 5% (4/80) <.01
prevalence oflymphadenopathy at unusual sites;
Note.-NS = not significant
five ofthe nine patients with tuberculous perito- a0nly the predominant finding was counted if different patterns coexisted.
Fig. 4.-Penitoneal carcinomatosis due to breast car- Fig. 5.-Tuberculous peritonitis in 30-year-old woman. Fig. 6.-Tuberculous peritonitis in 19-year-old worn-
cinoma in 58-year-old woman. Contrast-enhanced CT Contrast-enhanced CT scan shows omental cake an. Contrast-enhanced CT scan shows thin densely
scan shows omental cake (solid arrows) with ascites. (arrows) and diffuse mesentenc infiltration with nodules enhancing peripheral rim (omental line) (arrowheads)
Parietal peritoneum (open arrow) is also thickened. and thickened leaves. Also note loculated intraperitoneal that covers omental infiltration. Ornentum also ap-
fluid collection (A) and diffuse peritoneal thickening. pears to be uniform in thickness.
Fig. 7.-Tuberculous peritonitis in 32-year-old man. Con- Fig. 8.-Tuberculous peritonitis in 8-year-old child. Fig. 9.-Tuberculous peritonitis in 50-year-old man.
trast-enhanced CT scan reveals partially calcified mass- Contrast-enhanced CT scan shows small masses Contrast-enhanced CT scan shows high-density as-
es (closed arrow) in region of portacaval space. Note (arrows) in penidiaphragmatic region. cites (A) in peritoneal cavity.
small hypodense mass (open arrow) in spleen, which
was surgically proven to be tuberculous granuloma.
Multivariate Analysis sidered. With these data, tuberculous peritoni- larity. Ifthe result is zero or greater, tubercu-
A model of multivariate logistic analysis tis was predicted in 29 of the 42 patients, for a bus peritonitis can be suggested.
was performed with the following variables: sensitivity of 69% (confidence intervals, 55-
omental irregularity; omental line; splenic ab- 83%), whereas peritoneal carcinomatosis was
predicted in 85 of 93 patients for a sensitivity Discussion
normalities, including splenomegaly or calcifi-
cation; and mesenteric macronodule (Table 7). of 91% (confidence intervals, 85-97%). CT has been chosen recently as a major
Statistical analysis system software estimated Instead of using the probability drawn diagnostic technique for diffuse or focal peri-
the values of the logistic regression coeffi- from the equation that we suggested. a sim- toneal diseases. However, CT still poses
cients included in the expression z = a + 1i. pie rule can also be used for differentiating problems, such as low sensitivity for detect-
where cx is an intercept term of logistic regres- the diseases. The rule is to add one point if a ing minimal peritoneal disease, especially
sion, 3 is the regression coefficients, and x is mesenteric macronodule is present, one for when the lesions are less than 1 cm in diame-
the value of the independent variables. The z splenic abnormality, and two for omental ter [9]. Also common are nonspecific find-
value can be obtained by using the data in line and to subtract two for omental irregu- ings in benign or malignant diseases [10].
Table 7: z = -0.98 - 2.59 (omental irregular-
ity) + 2.59 (omental line) + 166 (mesenteric
IViLymph Nod. Distribution
macronodule) + I .60 (splenic abnormality).
The probability of tuberculous peritonitis in . Tuberculous Peritonitis Peritoneal Carcinomatosis
Site
each individual patient can be drawn from this (n=42) (n=93) p
considered, and if the predictive value was less 8Celiac represents the branches of the celiac axis.
bUnusual sites include the pericardial and paravertebral regions or the iliopsoas compartment.
than 0.5, peritoneal carcinomatosis was con-
not develop; macronodular involvement of land, OH, for her editorial assistance in the 9. Silverman PM, Osborne M, Dunnick NR, Bandy
several centimeters rarely occurs in abdominal preparation of the manuscript. LC. CT prior to second-look operation in ovarian
cancer. AJR 1988:150:829-832
tuberculosis [18]. In addition, although the
10. Cooper C, Jeffrey RB, Silverman PM, Federle MR
spleen is an organ rarely affected by meta-
Chun GH. Computed tomography of omental
stases [19], our study showed that the presence References pathology. J ComputAssist Tomogr 1986;I0:62-66
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Conclusion
2. Hunlick DH, Megibow AJ, Naidich DP, Hilton S. 13. Burack WR, Hollister RM. Tuberculous peritoni-
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Acknowledgment Gastminiest Radiol 1989:14:265-267
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