PATHOPHYSIOLOGY

Predisposing factors: Precipitating Factor:

Age: 64 years old Smoking
Gender: Male (3:2 compared to female) Alcohol drinking
Sun exposure

UV Radiation causes basal cells of skin to

accumulate genetic abnormalities

Basal cell growth & division becomes

dysregulated

Rapid growth & expansion of genetically

abnormal basal cells

Stretching of overlying epidermal Rate of tissue expansion > rate Uncontrolled & disharmonious
layer of neoangiogenesis neoangiongenesis in tumor tissue

Pearly surface
epidermal layer Telangiectasia

Tissue ischemia and necrosis

Invasion of local tissue
in central tumor

Central ulceration