PERHITUNGAN FARMAKOKINETIKA

1. T ½ Eliminasi : 3 Jam
K Eliminasi : 0.231/Jam
Vd : 4L/ kgBB
=4L x 50
=200 L = 200000 ml

Diketahui
F : 0.26
Cp : 0.063 μg/ ml
h : 7 Jam = 420 menit

2. Rate out (Kr2 )= Cp x Ke x Vd

= 0.063 μg/ ml x 0.231/Jam x 200000 ml
= 2910 μg/ jam
= 0.049 mg/ menit
3. Jumlah Obat Yang Harus Dilepaskan dari Sediaan (R)
Kr 0.0 49 mg/menit
R= = =0 .187 mg/menit
f 0.26
4. MD = Release Rate x h
= 0.187 mg/ menit x 420 menit
= 78.54 mg = 78540 μg

A 0.063
LD = = =0.24 μg
f 0.26
5. DT = MD + LD
= 78540 μg + 0.24μg
= 78540.24 μg