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Everything You Should Know About Pregabalin

AUGUST 20, 2019

1. What is Pregabalin?

Pregabalin (148553-50-8) is a drug that is mostly sold under the brand

name Lyrica in various regions in the world. It’s an anti-epileptic
medicine that is also referred to as anticonvulsant. The drug is used to
slow down brain impulses that lead to seizures. On the other hand,
Pregabalin affects the brain chemicals that send pain signals across the
body nervous system. The drug is also used in the medical world to treat
different pains caused by various diseases such as nerve pains caused by
fibromyalgia, diabetes, and even spinal cord injury pains.

Pregabalin exists capsules, extended-release, or long-acting tablets and also in

oral solution (liquid). All Pregabalin forms work in the same way, and your
doctor will be the best person to choose the right one for you depending on
your condition or what you want to achieve by the end of the dosage cycle.
Being an oral drug serves as the best pain drug for many patients who are
unconformable with regular injections. The drug also can lead to some severe

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side effects when overdosed or misused. Make sure you always follow the
dosage instructions for better results.

Pregabalin (148553-50-8) can be used together with other medications to aid

the treatment of onset seizures in children aged at least four years old and
adults too. For many years now, the drug has been playing a vital role in the
medical world, making it one of the most potent pain-relieving drug on the
market. The drug should only be taken under a doctor’s prescription for better
results. However, always make sure you get the Pregabalin from a reliable
seller or manufacturer around you.

2.Pregabalin mechanism of action

Pregabalin belongs to an anticonvulsants class of medications. Typically, the

drugs in this class work in the same way and are used in the treatment of
similar conditions. It’s not yet clear how exactly Pregabalin works, but it’s
believed to work through calming down the damaged nerves in the body that
lead to seizures or pains. The drug reduces the pains in the body that is caused
by various reasons or diseases. Talk to your doctor for more information about
Pregabalin.

3.Pregabalin Uses

In the United States of America, Pregabalin has been approved for use in the
treatment of diseases such as;

 Epilepsy
 Post-herpetic neuralgia or pains that occur after shingles
 Diabetic neuropathy pain and
 Fibromyalgia

Fibromyalgia is a health condition that involves widespread pains, such as in

the muscles, connective tissues, or heightened and painful response to touch.
In other parts of the world, like in Europe, Pregabalin is used in the treatment
of anxiety disorder, a condition that other medications are used to treat in the
United States of America. As mentioned earlier, Pregabalin is also used with
other drugs to enhance the results. Doctors can also prescribe the medication
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to patients with various conditions that can be treated or controlled by the

Pregabalin.

4.Pregabalin dosage

Pregabalin dosage depends on the condition under treatment. However, the

lowest dosage is 25mg, while the maximum is 600mg per day. Your doctor
will set the right dosage for you after examining your condition. Sometimes
the medics will advise you to start with low dosages, which can be adjusted
with time. In some exceptional cases, your doctor can increase the dosage
further. The Pregabalin dosage are as follows;

Adult Diabetic Neuropathy dosage

For immediate-release, the initial dosage is 50mgs that should be taken three
times a day. The dose can be increased by your doctor to 100mg to be taken
three times a day within the first week, which will be determined by how your
body responds to the first dosage. The medical examination is critical to
monitor the treatment progress. At this point, the Pregabalin dosage can be
stretched to a maximum of 300mg per day, but that should be done with time.
Beginners are always advised to start with low dosages to reduce the side
effects.
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The extended-release will require you to take an initial dosage of 150mg oral
dose once per day, and it’s recommended that you take it after the evening
meal. Your doctor can increase the dosage to up to the maximum dose of
330mg daily. The increase of dosage can only happen after the doctor
examines your progress and your body’s tolerance to Pregabalin. Remember,
don’t adjust the Pregabalin (148553-50-8) dosage without your doctor’s
guidance. It can lead to severe side effects.

The day that you will be switching the dosage take the usual morning dosage
as prescribed by your medic then start the new dosage after your evening meal.
Medical studies have revealed that taking high dosages of up to 600mg per day
doesn’t provide any additional benefits. Thus, you should stick to the
recommended dose. Taking the maximum 300 to 330gm per day is also not
recommended since it can lead to dose-dependent effects.

Postherpetic Neuralgia adult dose

Here the dosages are divided into two categories, immediate-release, and
extended-release, and they both differ in dosages. For instance, in immediate
release, the initial Pregabalin dose is 150mg to 300mg per day, which is
divided into two or three prescriptions in a day. Similarly, the dosages can be
increased to 300 per day after a few days depending on how your body
responds to the initial dosage. If the results are impressive, then the doctor
will have no reason to increase it. The medic can also lower the dosage further
in case you take the low dosages and experience severe side effects.

After taking the 300mg dosage for about two to four weeks, and the pain relief
is insufficient, the doctor can decide to raise it to about 600mgs daily to be
taken two or three times a day. Remember, 600mg per day is the highest
recommended dosage for all patients. Exceeding this level can lead to severe
Pregabalin side effects, which will be hard or costly to reverse.

For the extended-release:

Here, the initial Pregabalin dosage is 165mg that should be taken once per day,
and it’s recommended that you take it after the evening meal. There is also a
possibility for the dosage to be increased further to 330mg within the first
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week of dosage cycle. After two or for weeks of medication and there is no
significant improvement in the pains then your doctor can raise the dosage to
the maximum which 660mgs per day. When switching the dosages, take the
morning one for immediate-release then start the extended-release medication
after taking your evening meal.

Epilepsy adult dosage

For epilepsy treatment, the initial oral dosage is 150mg per day, which is
divided into two or three times. Just like in other therapeutic dosages, the
doctor can increase the dose to 600mgs per day and should also be divided to
be taken in two or three times a day. Here the maximum dosage is 600mg per
day.

The efficiency and effects of this drug are all dependent on the drug’s dosage.
No study has proven the importance of combining Pregabalin with gabapentin.
However, your doctor will advise you more on what drugs to use together with
this drug.

Fibromyalgia adult dose

Here the initial dose is 75mg taken twice a day and can be adjusted to 150mg
two times a day within the first week of dosage. The dosage can also be
increased further to 225mg to be taken twice a day. The maximum dosage for
fibromyalgia is 450mgs and a maintenance dosage of about 300mg to 450mg.
On the other hand, studies show that taking 600mgs per day doesn’t offer any
additional Pregabalin benefits but can result in severe side effects.

Pregabalin for Neuropathic pain

The initial dose is 75mg per day and can also be increased to 150mg per day.
In case, after two or three weeks dosage, there is no significant improvement,
then your medic can adjust it upwards to 300mgs. The recommended
Maintenance dosage ranges from 150 to 600mg divided dosages per day.

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5.Pregabalin results
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In the medical world, it’s evident that Pregabalin delivers quality and
impressive results for users who follow the dosage instructions. Since the first
approved the drug in 2004, millions of patients have benefited from
Pregabalin especially in managing nerve pains resulting from various diseases
such as Epilepsy, Post-herpetic neuralgia or pains that occur after shingles,
Diabetic neuropathy pain and Fibromyalgia. Depending on how your body
reacts with the Pregabalin, you can expect to enjoy the result within a very
short time.

The first few days of dosage gives your doctor the chance to evaluate your
progress before deciding on whether to adjust the dosage downwards or
upwards. Studies show that you should expect results within the first few days
of dosage. Pregabalin is a fast-acting drug, and you should, therefore, expect
the pains to be relieved within the early few days of dosage. In case you don’t
experience any improvement within the first week of taking your dose, inform
your doctor to adjust the dosage for better results. Human bodies are different,
and it’s not automatic that you get the results as quick as others will. Also
depending on the condition that you are under medication for, the results will
vary. Some of the typical Pregabalin results include;

Reduces Nerve pain

Pregabalin is a potent drug when it comes to minimizing pains that result from
nerve damage such as peripheral diabetic neuropathy, chemotherapy-induced
neuropathic pain, or Fibromyalgia. Different studies show that Pregabalin is
the most effective drug in reducing neuropathic pains. The supplement
remains effective when used alone or even when combined with other medical
supplements.

Enhances quality life for patients with Fibromyalgia

As mentioned earlier, Fibromyalgia is a condition where you suffer from

widespread pain. Its symptoms include poor quality of sleep, fatigue, anxiety,
depression, joint, and muscle stiffness. The drug helps patients control all
these effects.

Reduces Epileptic symptoms

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FDA approved Pregabalin (148553-50-8) for the treatment of epilepsy. This

drug is recommended for patients with partial epilepsy due to brain injury. It
is also used as an adjunctive therapy for people that other anti-epileptic
medications have failed to work.

Treatment of anxiety

Although in the United States of America, Pregabalin is not used to lower

anxiety levels, in Europe, the drug has proved to be an excellent solution.
Pregabalin is said to be used off-label to help in the treatment of anxiety
disorder in various parts of the world. There are also some undocumented
instances when your doctor can find it necessary to prescribe Pregabalin and
still deliver quality results. Both short-term and long-term medical studies
demonstrate that this drug can effectively treat moderate to severe anxiety in
individuals more so adults.

The secret to quality Pregabalin results is to involve your doctor in the whole
dosage process. Don’t adjust the Pregabalin dosage without informing your
medic. As much as you can easily purchase the drug from different online
stores, don’t start taking it without going for a medical check-up. This drug
has been potent in relieving pains caused by various reasons. Some athletes
also use Pregabalin to control the muscle pains, and spinal injury pains, which
are common due to intensive workouts and competitions.

6.Pregabalin half life

This is a fast acting-drug with an active Pregabalin half life of 6 hours.

Therefore, for better Pregabalin results, the dosages should be divided into
two or three per day. Being an oral drug, it makes it easy for you to get results
since it has a short elimination half-life. Always remember to stick to the
dosage instructions given by your doctor. Even if you take the lowest or
highest dosage, the half-life of this drug remains the same.

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7.Pregabalin side effects

Just like other drugs on the market today, Pregabalin can also expose you to
severe side effects if you overdose it. Majority of the Pregabalin side
effects are as a result of misuse or sometimes when your body system reacts
negatively with the drug. That’s why it’s always advisable to start with low
dosages, which can then be adjusted by your medics after monitoring how
your body responds to the medication. Some of the most common Pregabalin
side effects include;

 Dizziness –sometimes you might experience drowsiness while taking

this drug, but it should disappear after some time.
 Vomiting, dry mouth, and headaches are also other widespread side
effects that you might experience when taking this drug.
 Many Pregabalin users also complain of increased appetite, which in
turn, result in weight gain.
 There are also cases of a lack of muscle coordination, speech problems,
and lack of body balance.

All these Pregabalin side effects disappear after some time, but in case they
stay longer than expected, you should inform your doctor to help you get a
solution before the condition worsens. On the other hand, there are some

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severe side effects that you should contact your medic immediately you start
experiencing them, and they include;

 Vision problems, the moment you begin experiencing double vision, or

blurred vision or any changes in your eyesight don’t hesitate, call your doctor
immediately.
 Swelling of face, mouth lips, eyes, throat, tongue, neck, or head cases
should also be reported immediately.
 Other severe side effects include; blisters, itching, swelling of ankles,
lower legs, hands, and arms or chest pains.

The good news is that all these Pregabalin side effects can be controlled if you
inform your doctor in time although some conditions will disappear with time
when you experience the advanced effects mentioned above don’t continue
taking the dosage without informing your medic. Your doctor can decide to
stop the dosage if the situation is uncontrollable or suggest an alternative,
safer medication for you.

8.Pregabalin benefits

This is a drug that has proved itself to be among the most potent anti-epileptic
medicine on the market today. It has been used to relieve neuropathic pains
across the world, and in some regions like Europe, it was approved for the
treatment of anxiety. There are a lot of benefits that you will enjoy when
taking this drug, Pregabalin benefits which are as follows;

Delivers quality results

Medical studies have proved that Pregabalin provides quality results to all its
users who follow the dosage instructions. For those using it for neuropathic
pains, you can experience improvements even after taking your first dose.
Within the first week, you should start experiencing the full results, and that
gives the medics the chance to evaluate the medication process. No matter the
reason for using Pregabalin, the results are always impressive.

Oral drug

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Pregabalin is administered through the mouth, and therefore, there are no

injections involved. Thus, it serves as the best medication for users who are
uncomfortable with regular injections. You don’t have to worry about any
pains, and you can easily accompany this drug with other medicines so long as
you inform your doctor.

It has a long half-life

Compared to other oral medications, Pregabalin has a long active life in your
body system, which assures you of steady and quality results. Depending on
the condition that you are treating with this drug, you will only need to take
your dose for about two to three times a day and sometimes once per day after
the evening meal.

Easily accessible

You can easily buy Pregabalin powder in bulk or just enough for your
dosage cycle from various online stores or the nearest pharmacy since it’s
legal in many parts of the world. Your doctor will also be the right person to
show you where to buy it. This makes it easy for you to purchase and use the
drug without any fears of conflicting with the law.

Less severe side effects

Pregabalin exposes you to less severe side effects compared to other

anticonvulsants. You will only experience common side effects such as
headache, vomiting, among others for the first days of dosage, and they will
disappear. On the other hand, if you inform your doctor early enough, the
advanced effects can be easily controlled. However, for a better experience,
make sure you don’t use or make any dosage adjustments without informing
your physician.

9.Pregabalin reviews

Looking at various Pregabalin reviews, it’s clear that many users are satisfied
with the results they get after taking the drug. Pregabalin is regularly used as a
pain-relieving drug, and it has been receiving positive feedback from a

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majority of the users. Medical researchers have also filed different findings,
and that’s the reason why FDA approved it to be used in the treatment of
Epilepsy, Post-herpetic neuralgia or pains that occur after shingles, Diabetic
neuropathy pain and Fibromyalgia.

In other parts of the world like in Europe, Pregabalin has been approved for
the treatment of anxiety amongst the adults. However, there are also some few
reported cases where some users had the worst experience with the drug.
Drugs react differently with human bodies, and it’s not automatic that it works
for you just because it helped your friend. Other cases of severe side effects
have been attributed to overdosing and misuse of Pregabalin.

In summary, this is a great drug when used correctly and for the right reasons.
It has helped millions of people suffering from different diseases, as
highlighted above. Just like any other prescription drug, you shouldn’t take
the Pregabalin unless your doctor recommends it for you. In case you
experience side effects also inform your doctor immediately to help you
overcome them.

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10.Pregabalin for sale

The world is changing, and today, you can buy Pregabalin powder online on
our platform at an affordable price. Our website is user-friendly, making it
easy for you to maneuver from one product to another as well as make your
order within seconds. You can access our website via your smartphone, tablet,
or even your laptop. On top of that, we make deliveries across the world and
within the shortest time possible. You can buy Pregabalin in bulk or even just
enough for your dosage cycle.

We are the leading Pregabalin supplier in the region, and our affordable prices
don’t compromise the quality of our products. We offer a variety of quality
medical products in our online store. However, we always advise all our
customers to ensure that they undergo a medical checkup before they start
taking our products. Our medical products can lead to side effects when
misused or overdosed. Pregabalin for sale is also available at your nearest
pharmacy but make sure you get it from a reliable seller. Not all online or
physical medical stores offer quality products.

11.Pregabalin to treat Nerve pain and Anxiety

For many years now, Pregabalin has been essential in the medical world more
so in the treatment of nerve pains, commonly known as neuropathic pain. The
drug works by controlling the brain chemicals that send signals to your nerves,
which in turn reduces the level of pains in your body system. In the United
States of America FDA approved Pregabalin for treatment of nerve pains
caused by various diseases such as Epilepsy, Fibromyalgia, Post-herpetic
neuralgia or pains that occur after shingles and Diabetic neuropathy pain.

However, Pregabalin (148553-50-8) has not been approved for the treatment
of anxiety in the US, although there are reports that some users use it off-label
to control the condition. In other parts of the world like in Europe, Pregabalin
has been accepted in the treatment of anxiety in adults. There are also
unconfirmed reports that Pregabalin can be used to control depression. For
more information about Pregabalin, contact your doctor or consult with your
pharmacist.

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References

[1] Kim, S. C., Landon, J. E., & Solomon, D. H. (2013). Clinical

characteristics and medication uses among fibromyalgia patients newly
prescribed amitriptyline, duloxetine, gabapentin, or pregabalin. Arthritis care
& research, 65(11), 1813-1819.

[2] Goodman, C. W., & Brett, A. S. (2017). Gabapentin and pregabalin for
pain—is increased prescribing a cause for concern?. New England Journal of
Medicine, 377(5), 411-414.

[3] Lam, D. M., Choi, S. W., Wong, S. S., Irwin, M. G., & Cheung, C. W.
(2015). Efficacy of Pregabalin in acute postoperative pain under different
surgical categories: a meta-analysis. Medicine, 94(46).

[4] Baldwin, D. S., Ajel, K., Masdrakis, V. G., Nowak, M., & Rafiq, R. (2013).
Pregabalin for the treatment of generalized anxiety disorder: an
update. Neuropsychiatric disease and treatment, 9, 883.

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