t(jam) Cp (tunggal) Cp TERMINAL Cp (Residual 1) Cp Distribusi CP (Residual 2)

0 0 4.0656 -4.0656 12.552 16.6176 Model Ko

0.25 9.593 3.8721555188 5.7208444812128 11.185631081 5.4647865997554 100
0.5 12.122 3.6879152798 8.4340847201707 9.96800053215 1.5339158119773
0.75 12.951 3.512441338 9.43855866204 8.88291718989 0.5556414721497
1 11.342 3.3453165858 7.9966834142075 7.9159524067 0.0807310075071
1.5 9.215 3.0345445082 6.1804554917821
2 7.881 2.752642429 5.1283575710403
10
3 5.389 2.2649695918 3.1240304082164
4 3.872 1.8636954796 2.0083045204375
5 2.439 1.5335132326 0.9054867673536
6 1.692 1.2618278364 0.430172163591
8 0.848
10 0.58 1
0 2 4 6
12 0.388

Persamaan Farmakokinetika Kurva D

Y = persamaan distribusi + persamaan eliminasi - persamaan absorbsi 7

Y = (12.552e-0.461x)+(4.0656e-0.195x)-(17.062e-4.765x)
6 f(x) = 12.5522374043485 e
R² = 0.995693092820313
5

0
1.4 1.6 1.8 2 2.2
 Model Kompartemen Kurva Terminal
100 0.9
0.8 f(x) = 4.06563925020018 exp( − 0.195468824042157 x )
R² = 0.999732065988209
0.7
0.6
0.5
10
0.4
0.3
0.2
0.1
1 0
0 2 4 6 8 10 12 14 7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5

Kurva Distribusi Kurva Absorbsi

7
18

6 f(x) = 12.5522374043485 exp( − 0.460676215665799 x ) 16 f(x) = 17.0620443243294 exp( − 4.76527710919916 x )

R² = 0.995693092820313 R² = 0.998529598257334
14
5
12
4
10
3 8

2 6

4
1
2
0 0
1.4 1.6 1.8 2 2.2 2.4 2.6 2.8 3 3.2
0 0.1 0.2 0.3 0.4 0.5 0.6
468824042157 x )

11.5 12 12.5

9916 x )

0.5 0.6
t(jam) cp (mcg/ml) Cp Terminal Cp (Residual 1) Cp Distribusi
0 0 2.1283 -2.1283 7.6435
0.25 4.115 2.0377037048718 2.0772962951282 6.7251593034921
0.5 5.156 1.950963862636 3.20503613736396 5.9171541384636
0.75 5.64 1.8679163139428 3.7720836860572 5.2062280636469
1 5.519 1.788403887286 3.73059611271356 4.5807173543974
1.5 5.152 1.639388881217 3.51261111878323
2 4.29 1.502790238247 2.78720976175293
3 2.901 1.26278997503 1.63821002496961
4 2.044 1.061118498412 0.982881501587794
5 1.356 0.891654582264 0.46434541773625
6 0.912 0.749254579259 0.162745420740846
8 0.53
10 0.37
12 0.264

Persamaan Farmakokinetika
Y = persamaan distribusi + persamaan eliminasi - persamaan absorbsi
Y = (7.6435e-0.512x)+(2.1283e-0.174x)-(9.4445e-2.564x)
 Cp (Residual 2)
9.7718 Model Kompartemen K
4.64786300836389 10 0.6
2.71211800109959
1.43414437758967 0.5 f(x) = 2.12833
R² = 0.999673
0.850121241683812
0.4

0.3

0.2

0.1

1 0
0 2 4 6 8 10 12 14 7.5 8 8.5 9

Kurva Distribusi K
tika
4 12
persamaan absorbsi
3.5
4445e-2.564x) f(x) = 7.64351739971023 exp( − 0.511779814243493 x )
R² = 0.998894779078298
10
3 f(x) = 9.44448941536
R² = 0.991593423480
8
2.5

2 6

1.5
4
1
2
0.5

0 0
1.4 1.6 1.8 2 2.2 2.4 2.6 2.8 3 3.2 0 0.1 0.2
 Kurva Terminal
0.6

0.5 f(x) = 2.12833684610361 exp( − 0.174231975849963 x )

R² = 0.999673356089248
0.4

0.3

0.2

0.1

0
7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5

Kurva Absorbsi
12

10
f(x) = 9.44448941536086 exp( − 2.5635416133703 x )
R² = 0.991593423480195
8

0
0 0.1 0.2 0.3 0.4 0.5 0.6