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  • Diabetes Melitus

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    Daniel Bolocan
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    Patients who undergo pancreatic resection for benign pancreatic disease often develop diabetes due to the removal of pancreatic tissue. Autotransplantation of islet cells isolated from the resected pancreas can avoid diabetes, maintaining insulin independence in 40-50% of cases. The success of islet cell autotransplantation depends on the number transplanted and underlying pancreatic disease, with portal vein thrombosis being the most common complication as islets are perfused into the liver.

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    Patients who undergo pancreatic resection for benign pancreatic disease often develop diabetes due to the removal of pancreatic tissue. Autotransplantation of islet cells isolated from the resected pancreas can avoid diabetes, maintaining insulin independence in 40-50% of cases. The success of islet cell autotransplantation depends on the number transplanted and underlying pancreatic disease, with portal vein thrombosis being the most common complication as islets are perfused into the liver.

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    15 views1 page

    Diabetes Melitus

    Uploaded by

    Daniel Bolocan
    Patients who undergo pancreatic resection for benign pancreatic disease often develop diabetes due to the removal of pancreatic tissue. Autotransplantation of islet cells isolated from the resected pancreas can avoid diabetes, maintaining insulin independence in 40-50% of cases. The success of islet cell autotransplantation depends on the number transplanted and underlying pancreatic disease, with portal vein thrombosis being the most common complication as islets are perfused into the liver.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    Patients who undergo extensive pancreatic resection for benign pancreatic disease (chronic

    pancreatitis, benign tumor) are subject to significant metabolic complications and may develop
    pancreatoprive diabetes which is particularly difficult to balance due to the absence of a counter-
    regulatory mechanism. Autotransplantation of islets of Langerhans after isolation from the
    resected pancreatic segment avoids the development of diabetes. Insulin independence can be
    maintained after this procedure in 40 to 50% of cases. The success rate depends on the number of
    islets transplanted and the nature of the pancreatic disease. Complications from this procedure
    are rare, the most common being portal vein thrombosis through which islets are perfused into
    the liver.

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