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Process Owner: Kayla Burns, Justin Croft, Ashlie Gamero, Holly Johnson, Date Approved:
Olivia Moore, Karlie Nate
(This document is confidential and proprietary to Madison Memorial Hospital. Unauthorized use or copying without written consent is strictly prohibited.)
Purpose/Summary:
Purpose
The purpose of this policy is to use heparin in the prevention and treatment of deep vein
thrombosis (DVT) and pulmonary embolism (PE) in a safe and effective manner.
Summary
Heparin is a medication that can be used to prevent and/or treat venous thromboembolism
(VTE). One issue that can put patients in danger is when too much heparin is given or when they
are on heparin for too long. Another contributing factor to heparin not being utilized correctly is
when staff members do not understand the usage of heparin and patients do not correctly
understand what heparin is and what they are on it for. This policy addresses these two concerns
and others by outlining staff training, patient education, administering heparin, prevention and
treatment of VTE, and how to assess patients before, during and after heparin administration.
Definitions:
● Venous thromboembolism (VTE): refers to a blood clot that originates in one’s veins
(American Heart Association, 2017).
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● Pulmonary embolism (PE): occurs when a DVT breaks free from its place of origin and
travels to the lungs and blocks some or all blood flow (American Heart Association,
2017).
● Deep vein thrombosis (DVT): is when blood clots in a deep vein, most commonly the
leg, but can also occur in the arm or other veins (American Heart Association, 2017).
● Heparin Induced thrombocytopenia (HIT): is an immune-mediated disorder that
causes antibodies to bind to platelet factor four and heparin causing thrombocytopenia
(Gowthami A., 2014).
● Thrombocytopenia: Thrombocytopenia...is a condition in which your blood has a lower
than a normal number of blood cell fragments called platelets (PLATE-lets)...When your
blood has too few platelets, mild to serious bleeding can occur. Bleeding can occur inside
your body (internal bleeding) or underneath your skin or from the surface of your skin
(external bleeding) (Thrombocytopenia, n.d.).
● Heparin: An anticoagulant (Yoost & Crawford, 2020).
● Anticoagulant: A medication that decreases fibrin formation, which prevents the
formation of blood clots (Yoost & Crawford, 2020).
● Activate partial thromboplastin time (aPTT): A laboratory value used to measure
appropriate levels of heparin (Lewis et al., 2017).
● Factor Xa Inhibitors: Medications that prevent the formation of factor Xa, which
prevents coagulation (Lewis et al., 2017).
● Anti-Xa test: Assay that measures antithrombin levels (Newall, 2013).
● Complete Blood Count (CBC): A test for diagnosis that includes a count of red blood
cells, a count of white blood cells, a differential white blood cell count, the hematocrit,
RBC indices, and level of hemoglobin (Yoost & Crawford, 2020).
● Obesity: A body mass index (BMI) of 30kg/m2 (Lewis et al., 2017).
● Body mass index (BMI): Weight in pounds multiplied by 703 and divided by height in
inches squared (Lewis et al., 2017).
● Adverse Reaction: a dangerous reaction by the body to the drug that is being used
(Lewis et al., 2017).
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3. Patients and staff will be educated on the purpose of heparin and its side effects.
4. Patients and staff will be educated on the signs and symptoms of DVT and PE.
Quality: The requirement for healthcare staff to review this policy on an annual basis, and after
any adverse event, will help the staff to consistently administer heparin in a safe and beneficial
way. It will help to remind them of the importance of these policies in providing high-quality
Providing the Exceptional Experience: Educating staff about how to properly care for patients
getting heparin will help them take better care of their patients. Educating patients about heparin
implications will empower them to take part in their own care plans and be their own advocates.
Following the administration protocol will serve to decrease mistakes and adverse events (such
as bleeding and VTEs), helping patients avoid these negative experiences while in the hospital.
Ensuring Our Future: Following this policy and the procedures therein will ensure that adverse
events pertaining to heparin administration will be decreased. This will protect the reputation and
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Monitoring and
Measuring
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Assessment
● Cancer
● Heart failure.
● Family history.
● Acute infection.
● Respiratory failure.
● Recent surgery (Joseph, et al., 2014).
● Chest pain.
● Dyspnea
● Anxiety
● Restlessness
● O2 < 80%
● Cyanosis
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Step 5 Nurses will assess the patient and report any significant
changes to the provider (Rules of the Idaho Board of
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Step 1 D-Dimer
● A diagnostic test that looks at the cross-linked
Diagnostic Tests fibrin clot that is typically elevated in someone
that has a VTE.
Compression ultrasonography
● Preferred test to diagnose.
● Venous segments should easily compress, but
when there's a VTE it does not compress.
● This test compresses the veins to see if there is a
VTE.
● Utilizes a Doppler to identify which vessels to
compress (Wells, Anderson, 2013).
aPTT
● Used to monitor coagulation rates among
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patients.
anti-Xa test
● More sensitive and accurate in measuring
coagulation rates (Thom, Cameron, Robertson,
Watson, 2018).
Step 2 DVT:
● Unilateral calf/thigh pain.
Signs and ● Leg swelling.
symptoms ● Redness
PE:
● Dyspnea
● Chest pain.
● Both of those can happen (Wells, Anderson,
2013).
● Also see Procedure 6, Step 1 for more
information on signs and symptoms.
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● Administering heparin.
● Avoid tight clothing.
Prevention ● Physical activity.
Precautions ○ Frequent ambulation and range of
motion exercises will decrease the
chances of clot formation.
● Healthy diet.
○ Visit foodpyramid.com for ideas on how
to maintain a well-balanced diet.
● The use of compression stockings.
● Sequential compression devices (Joseph, et al.,
2014).
Procedure 5: Administration
Overview Details Quality
Records
Administration Instructions for the administration of heparin.
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Step 2
Obtain an order Obtain an order from the provider, written or verbal, for
heparin administration. Make sure that the order is in
the patient's chart (Idaho, 2013).
Step 3
Gather Supplies Gather all necessary supplies to administer heparin. See
and prepare Equipment and Suitable Environment on page 4.
medication Follow the 6 rights of medication administration
(Yoost & Crawford, 2020).
Step 4
Patient education Teach patients about the implications of heparin. For
more information on patient education, refer to
Procedure 3.
Step 9
Monitoring and Nurse(s) will document each step of the protocol as
Measuring follows to ensure that this protocol was followed in
every case of VTE. Nurse Manager (or other directed
healthcare administrator) will review documentation to
ensure nurse compliance after each incidence of VTE.
Holding nurses accountable for following protocols
will increase compliance (Cline, 2016).
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Internal References:
● Proper documentation under each patient in the Cerner electronic health record.
● Provider orders.
● Location/type of heparin administered.
● Lab values.
● Pharmacy instructions about drug administration.
External References:
American Heart Association (2017). What is Venous Thromboembolism (VTE). American
thromboembolism/what-is-venous-thromboembolism-vte
Chapelle, C., Rosencher, N., Zufferey, P., Mismetti P., Cucherat, M., Laporte, S. & Meta-Embol
Controlled Trials. Arthroscopy: The Journal of Arthroscopic and Related Surgery. 30(8),
987-996. https://doi.org/10.1016/j.arthro.2014.03.009
https://doi.org/10.1097/nna.0000000000000311
Clinical Pharmacology [Internet]. Tampa (FL): Elsevier. C2020- [cited March 16].
http://www.clinicalpharmacology.com
Eckhardt, Ann & Jarvis, Carolyn (2020) Physical Examination and Health Assessment.
Elsevier.
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https://connect.elsevierperformancemanager.com/#/content/skills/13729/checklist
Garcia, David & Crowther, Mark. (2020). Risks and prevention of bleeding with oral
of-bleeding-with-oral-anticoagulants
ip.com/Forms/drugoptions.aspx?cpnum=289&n=Heparin&t=0
Idaho Department of Health and Welfare (2013). Rules and minimum standards for hospitals
in Idaho.16.03.14. https://adminrules.idaho.gov/rules/2013/16/0314.pdf
Idaho Office of the Administrative Rules Coordinator. (2016). Rules of the Idaho Board of
Joseph, L., Casanegra, A. I., Dhariwal, M., Smith, M. A., Raju, M. G., Militello, M. A., …
https://doi.org/10.1111/jth.12592
Lewis, S. L., Bucher, L., Heitkemper, M. M., Harding, M. M., & Kwong, J., & Roberts, D.
[eBook edition].
https://pageburstls.elsevier.com/#/books/9780323328524/cfi/6/130!/4/2/6/4@0:0.00
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Lilley, L. L., Collins, S. R., & Snyder, J. S. (2017). Pharmacology and the nursing process (8th
https://pageburstls.elsevier.com/#/books/9780323358286/cfi/6/4!/4@0:0
Maynard G., Humber D., & Jenkins I., (2014). Multidisciplinary Initiative to Improve Inpatient
https://doi.org/10.2146/ajhp130108
Medline Plus. (2017). Heparin Injection-How Should This Medication Be Used? US National
Newall, F. (2013). Anti-factor Xa (anti-Xa) assay. Haemostasis: Methods and Protocols, 992,
265-272. https://doi.org/10.1007/978-1-62703-339-8_19
Onishi, A., Ange, K.S., Dordick, J.S., & Linhardt, R.J. (2016). Heparin and anticoagulation.
heparin.rpi.edu/main/files/papers/570d6646d2b110.85691577.pdf
Rules of the Idaho Board of Nursing, IDAPA 23.01.01 (2019). Idaho Administrative
Code. https://adminrules.idaho.gov/rules/current/23/230101.pdf
Thom, I., Cameron, G., Robertson, D., & Watson, H.G. (2018). Measurement of
rivaroxaban concentrations demonstrates lack of clinical utility of a PT, dPT and APTT
https://doi.org/10.1111/ijlh.12846
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http://www.nhlbi.nih.gov/book/export/html/4876
2128-2132. https://doi.org/10.1111/jth.14264
https://www.ncbi.nlm.nih.gov/books/NBK538247/
Wells, P. & Anderson, D. (2013). The diagnosis and treatment of venous thromboembolism.
2013.1.457
Wang, M.L., Blum, K.A., Martin, P., God, A., Auer, R., Kahl, B.S., Jurczak, W., Advani,
R.H., Romaguera, J.E., Williams, M.E., Barrientos, J.C., Chmielowska, E., Radfod, J.,
Stilgenbauer, S., Dreyling, M., Jesrzejckak, W.W., Johnson, P., Spurgeon, S.E., Zhang,
L., Baher, L., Cheng, M., Lee, D., Beaupre, D.M., & Rule, S. (2015). Long-term follow-
up of MCL Patients treated with single-agent ibrutinib: updated safety and efficacy
https://doi.org/10.1182/blood-2015-03-635326
https://pageburstls.elsevier.com/#/books/9780323508643/cfi/6/4!/4/2/6/2/2@0:3.61
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https://www.uptodate.com/contents/clinical-use-of-coagulation-tests?
search=providers%20order%20for
%20heparin&source=search_result&selectedTitle=7~150&usage_type=default&dis
play_rank=7#PATIENT_INFORMATION
Requirements:
Idaho State Board of Nursing (2016) has the requirement regarding patient education:
“The act of teaching patients and their families, for the purpose of improving or
The Idaho Department of Health and Welfare (2013) has the following requirements regarding
“There shall be evidence of continuing education and training for the staff” (p.39)
Idaho Department of Health and Welfare (2013) has the following requirement regarding patient
documentation:
“The hospital shall maintain medical records that are documented accurately and timely,
“12. Record Content. The medical records shall contain sufficient information to justify
the diagnosis, warrant the treatment and end results. The medical record shall also be
legible, shall be written with ink or typed, and shall contain the following information: iii.
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The Idaho State Board of Nursing (2016) requires the following regarding reporting patient
status changes:
“i. Observe and Report. The nurse shall observe the condition and signs and symptoms of
a patient, record the information, and report to appropriate persons any significant
Idaho Department of Health and Welfare (2013) has set the following requirements for the
“Individual patient care plans shall be developed, implemented and kept current for each
inpatient. Each patient care plan shall include but is not limited to: (10-14-88)
c. A plan devised to include both short-term and long-term goals; and (10-14-88)
d. Patient and family teaching plan both for hospital stay and discharge; and (10-14-88)
needs.” (p.18)
Idaho Department of Health and Welfare (2013) has set the following requirements for
administration of medications:
“Drugs shall be dispensed and administered only upon written or verbal order of a
member of the medical staff authorized to prescribe. Verbal orders for drugs shall be
given only to those health care practitioners empowered to accept orders under Idaho law
and written hospital policies and procedures. Verbal or telephone orders shall be signed
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hospital's policy. The person accepting the verbal or telephone orders shall meet the
Quality assurance will be determined after the patient’s stay at the hospital. This
experience will give insights into each patient’s individualized experience, and how if they
thought heparin prevented VTEs during their stay. Asking each patient about their opinion on
heparin will allow the hospital to see what worked for the patient or what could be changed to
improve their stay. After the patient’s stay, they will be asked to rate how they felt heparin
Another way in which quality will be maintained is that all staff involved in the
administration of heparin, will be mandated to take training on heparin therapy. This will ensure
that each staff member is staying up to date on the most current evidence-based practice to
going on. Not only does the medication need to be given, but the patient should have an
understanding of heparins side effects, what it does, and why the provider prescribed it. This will
demonstrate that the patient not only understands their treatment plan, but that it also shows the
nurse understand heparin therapy. The charge nurse will routinely ask each patient on heparin if
they know what it’s for, what it does, and why they are getting it and will document patient
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education accordingly in the patient's electronic health record. By doing this it will ensure that
patient’s not only understand their care plan, but also that the nurse taking care of them does too.
Disclaimer:
This resource is meant to assist staff and will not apply to all possible circumstances. Although
safety is the main goal, it cannot always be guaranteed. Unique circumstances may require
Appendix I
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