III. Multiple choice questions: 1. Which of the following mechanisms is most frequently responsible for chemical degradation? a) Oxidation b) Photolysis c) Hydrolysis d) Decarboxylation Correct option: c) 2. Which of the following equations is used for predicting the shelf life of a drug product? a) Michaelis-Menten equation b) Arrhenius equation c) Hixon-Crowell equationd) Henderson-Hasselbalch equation Correct option: b) _ As the temperature increases, the degradation of a) increases b) decreases ¢) remains constant d) stops Correct option: a) \ Fora first-order degradation dn 1g a) Aplot of concentration versus time yield a straight line b) A plot of the logarithm of concentration versus ine, . . ¢) A plot of concentration versus the logarithm of time ou poe d) Aplot of the logarithm of concentration versus asia ved line Correct option: b) The biological half life of a drug (first order kinetics) is represented by: a) 1/K b) logK c) 0.693/K d) 2.303/K Correct option: ¢) . The rate of a zero order reaction is: a) Independent of reactants b) Dependent on the concentration of one reactant c) Dependent on the concentration of both reactants d) Dependent on the residual concentration of the reactants Correct option: a) . Which of the following does not play a part in determining the rate of a reaction? a) Temperature b) Solvent c) The presence of a catalyst d) The equilibrium constant Correct option: d) . The modern definition of oxidation is: a) Loss of oxygen b) Gain of oxygeno c) Loss of one or more electrons d) Gain of one or more electrons Correct option: ¢) Factivation of the chemic The occelerated stability studien are valid only when anergy of activation OTS Shem ' reaction is: a) Less than 10 keal/mol b) 10 to 30 kcal/mol ©) 30to 70 keal/mol d) More than 70 kcal/mol Correct option: b) For any chemical reaction, the molecularity is always __— than the order, a) Lower b) Higher c) Equal d) May be higher or lower Correct option: b) The rate equation for a chemical reaction is reported as (-de/dt) = ke . The order of the reaction is: a) Zero order b) First order c) Pseudo first order d) Second order Correct option: b) The order of reaction followed during hydrolysis of ethy| acetate in acid medium is: a) First order b) Pseudo first order c) First and second order d) Pseudo first and second order Correct option: d) . Photodecomposition of drugs usually follows: a) Zero order reaction b) First order reaction c) Pseudo first order reaction d) Second order reaction Correct option: a)19, |, The rate of hydrolysis can be controlled by a) Addition of buffers b) Decreasing the solubility c) Complexing the drug d) Removing of water Correct option: a) , The plot obtained by taking ti P ry ig time on the x-axis and concentration of the reactant on the y- axis for a pseudo-first order reaction is: a) Straight line b) Curve c) Parabola d) Hyperbola Correct option: b) . The integral equation k = x/at(a-x) is related to: a) Zero order reaction b) First order c) Pseudo first order reaction d) Second order reaction Correct option: d) | A second order reaction behaves as a pseudo-fist order reaction when the concentration oft a) One reactant is significantly higher than the other reactant b) The concentration of both reactants is high c) The concentration of both reactants is low d) The concentration of the two reactants is equal Correct option: a) Which of the following can be designated as the molecularity of a reaction? a) Zero b) Half c) One d) One and half Correct option: c) The epimerisation of tetracycline is a: a) One sided reaction b) Two sided reaction¢) Unimolecular reaction d) Multimolecular reaction Correct option: ©) B 20. For the results of accelerated stability studies of solution dosaj energy of activation should be in the range of: a) Oto 10 kcal/mole b) 11 to 30 kcal/mole ¢) 31 to 60 kcal/mole 4) More than 50 kcal/mole Correct option: b) ge form to be valid, the