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Glycine
Lipinski rule is also called rule of five (RO5) is a rule of thumb to estimate drug likeness or
establishing if a chemical compound with specific pharmacological or biological activity has
particularities that would make it a likely orally active drug in human beings. (Walters, 2012)
Lipinski’s rule states that, in general, an orally active medication has no more than one
contravention of the following criteria:
● Not more than 5 hydrogen bond donors
● Not more than 10 hydrogen bond acceptors
● A molecular mass less than 500 daltons
● An octanol-water separation coefficient log P not bigger than 5
Albumin
NSAID + warfarin
Question 2
Question 3
‘Absorption, distribution, metabolism and excretion of drugs can have major influences on
the potency of a drug. ‘Discuss.
Sublingual
Oral
Rectal
Application to epithelial surfaces (e.g. skin, cornea, vagina and nasal mucosa)
Inhalation
Injection
Subcutaneous
Intramuscular
Intravenous
Intrathecal