Pathology of the ovaries

Wo et al (2009) stated that only in the world of medical treatment concepts such as poison heals

cancer and radiation cures it. They were of the view that doctor’s with a reasonable

understanding of cellular pathology could agree that disease promoting effects can cause damage

in the long-term well after treatment as well as the use of ionizing radiation would cause

secondary cancers, They believe that more patients are dying of radiation-induced secondary

cancers, which oncologists are often misdiagnosing as the primary cancer spreading. They listed

these effects as pathologies of the ovary caused by radiation treatment.

 Cranio-spinal irradiation elicited significant hormonal changes in women that affected

their ability to become pregnant later in life.

 Women treated with abdomino-pelvic radiation have an increased rate of uterine

dysfunction leading to miscarriage, preterm labor, low birthweight, and placental

abnormalities.

 Early menopause results from low-dose ovarian radiation.

 Radiation therapy can disrupt the functioning of the hypothalamic-pituitary axis, directly

cause ovarian failure, or cause damage that makes the uterus unable to accommodate the

growth of a fetus to full term.

 Disruption of the hypothalamic-pituitary-ovarian axis is a well-established potential

complication of cranial irradiation that can lead to amenorrhea and infertility. Radiation-

induced damage is possible within the hypothalamus, pituitary gland, or both, and can

lead to dysregulation of the hormonal milieu responsible for fine regulation of

menstruation and fertility.

Reference
Wo, J.Y., & Viswanathan, A.N. (2009). Impact of Radiotherapy on Fertility, Pregnancy, and
Neonatal Outcomes in Female Cancer Patients. International Journal of Radiation Oncology
*Biology*Physics,73(5), 1304-1312.doi: 10.1016/j.ijrobp.2008.12.016