Professional Documents
Culture Documents
State of the Science acupuncture point. Senelar [9] described the acupuncture
The strongest initial evidence for the validity of acupunc- point to be located in a vertical column of loose connective
ture was its efficacy in veterinary medicine and, sub- tissue, surrounded by denser connective tissue of the skin.
sequently, in human infants, populations in which Within the column of loose connective tissue, a lymphatic
suggestibility and placebo effects could not explain the trunk is coupled with an arteriole and a vein. The lympho-
observed results [5–7]. Subsequently, it was shown in vascular bundle is surrounded by a rich plexus of unmyeli-
animals, and later in humans, that real acupuncture caused nated cholinergic nerve fibers. The epidermis thins at the
analgesia, and sham acupuncture did not. The initial stud- surface of the acupuncture point and there is modification
ies were conducted on experimental pain models in which of the collagen fibers (Fig. 1). Insertion of an acupuncture
placebo had a minimal impact relative to chronic pain needle primarily activates the A-δ fibers [10]. The A-β fibers
disorders. Several controlled trials of patients with chronic also may be activated. Deeper insertion may stimulate group
pain also have shown a statistically significant difference II and group III fibers. Calcitonin gene-related peptide
between acupuncture and placebo conditions [8]. Indeed, (CGRP) and substance P are released locally with associated
more is known about the mechanisms of action of acu- vasodilation and increased tissue temperature. At the level of
puncture than many pharmaceutic and physical agents in the dorsal horn of the spinal cord, interneurons segmentally
routine use. Examples include the mechanism of action of release dynorphin and enkephalin [11]. At the level of the
inhaled anesthetics in general anesthesia and the mecha- brain stem, the reticular formation (RF), the nucleus raphe
nisms of action of anticonvulsants or spinal cord stimula- magnus (NRM), and the nucleus reticularis magnocellularis
tors used for chronic pain states. (NRM) may be activated [12]. These nuclei trigger descend-
Throughout the past three decades, several lines of evi- ing serotonergic and noradrenergic pathways that synapse
dence have been explored to gain insight into the scientific onto dorsal horn neurons, causing the release of enke-
basis of acupuncture. The findings have been summarized phalin. The periaqueductal grey (PAG) at the level of the
in chronologic order in Table 1. midbrain also has descending enkephalinergic input. These
fibers activate the NRM and the reticularis magnocellularis
nuclei as they descend from the midbrain to synapse onto
Acupuncture Physiology the dorsal horn neurons in the spinal cord. Dynorphin and
In 1979, the basic morphologic structure of an acupuncture enkephalin are the endogenous opiates generally found
point was described by Senelar [9] based on the statistical from the spinal cord to the midbrain. In contrast, at the
analysis of a large number of histologic sections of acupunc- level of the hypothalamic pituitary axis, β-endorphin is the
ture points in rabbits, cats, mice, and human cadavers. primary neuropeptide. Through these endorphinergic
Although the components of the acupuncture point pathways, the hypothalamus has widespread influence
structure are not unusual in themselves, they are con- throughout the central nervous system, including the
centrated and organized in a distinctive fashion to form the periventricular nuclei of the thalamus, the nucleus acum-
446 Anesthetic Techniques in Pain Management
bens of the limbic system, the amygdala and diencephalon, nucleic acid also have been demonstrated to increase within
and the PAG [13–15]. The hypothalamic-pituitary-adrenal the spinal cord and higher centers after acupuncture, indi-
axis also controls serum cortisol levels. Cholecystokinin cating early gene expression. This may explain the cumula-
octapeptide, c-fos, and proenkephalin messenger ribo- tive and prolonged effects of acupuncture [16–20].
Acupuncture in Pain Medicine: An Integrated Approach to the Management of Refractory Pain • Ahadian 447
Figure 3. Homuncular
arrangement of the
auricular reflex micro-
system originally
described by
Paul Nogier. An
inverted body is
topographically
represented on the
external auricle.
Health, researchers, and practitioners who convened in as anxiety, sleep disturbances, and bowel dysfunction. It is
November, 1997, clinical studies have shown that acupunc- the rule, not the exception, for patients with chronic pain
ture is an effective treatment for nausea caused by surgical to have several of these symptoms simultaneously. Failure
anesthesia, cancer, and for dental pain experienced after to address these disturbances frequently leads to failure of
surgery. The panel also found that acupuncture is useful treatment despite appropriate and conscientious use of
when administered alone or when combined with conven- conventional therapies. Acupuncture offers a valuable tool
tional therapies to treat addiction, headaches, menstrual in the armamentarium of the pain physician for manage-
cramps, tennis elbow, fibromyalgia, myofascial pain, ment of functional disturbances.
osteoarthritis, lower back pain, carpal tunnel syndrome, and
asthma, and to assist in stroke rehabilitation [25]. Chronic opiate therapy
Administration of opiates for chronic pain states can no
longer be discounted as controversial and limited to patients
Acupuncture in Pain Medicine with terminal disease. It is now, and will continue to be,
There are three areas of pain medicine in which integration a critical part of the overall management of intractable
of acupuncture with allopathic medicine offers distinct malignant and non-malignant pain disorders. However,
advantages. These include musculoskeletal disorders, func- regardless of the route of administration (oral, parenteral, or
tional disturbances, and chronic opiate therapy. intrathecal), obtaining long-term success with these agents
poses numerous challenges. Among others, these challenges
Musculoskeletal disorders may include opiate side effects, physiologic tolerance,
Because of the ongoing demographic change facing medi- psychogenic dependence, and withdrawal. Combined
cine, musculoskeletal disorders will be a leading cause of opiate-acupuncture therapy is an invaluable technique for
disability and decreased quality of life for the elderly popu- achieving success with chronic opiate administration. Con-
lation. Because of advancing age and comorbidities, many of current acupuncture treatments may be considered adjuvant
these patients will not be surgical candidates or will choose therapy, a concept well known to pain physicians. Twenty
non-surgical alternatives. Furthermore, the untoward effects percent to 50% reduction in overall opiate requirement is
of analgesic medications are not well tolerated in this group not unusual after an initial course of acupuncture; the need
of patients; therefore, their options are few. Acupuncture for dose escalation may be substantially reduced or elimi-
offers an excellent choice. A recent prospective, controlled nated with acupuncture-maintenance therapy. Acupuncture
trial comparing acupuncture with no treatment for patients is a powerful tool for the management of situations in which
with advanced osteoarthritis of the knee who were awaiting opiate withdrawal is a central issue. This may occur when
total knee replacement showed a highly statistically signifi- changing from one opiate to another (opiate rotation),
cant difference between the groups. The acupuncture group or when opiate therapy is discontinued. In animal studies,
improved in walking, climbing stairs, and pain levels; the electroacupuncture has been shown to reduce withdrawal
control group deteriorated as time passed [26]. Although behavior by 50% [30]. For patients who are addicted to
knee osteoarthritis appears to be one of the best indications heroin, electroacupuncture suppressed the clinical features
for acupuncture, other common musculoskeletal disorders of withdrawal. In all of the patients who were observed,
such as cervical and lumbar facet disease, painful disorders successful treatment was associated with an increase in
of the hip joint, and myofascial pain syndrome also are cerebrospinal fluid met-enkephalin levels [31]. Auricular
appropriate indications [27–29]. electroacupuncture and naloxone have been used success-
fully to achieve rapid opiate detoxification in patients
Functional disturbances with chronic pain [32].
The term functional disturbances is used by many physicians
to describe subjective complaints that are rarely associated
with positive physical or laboratory findings, definitive Case Reports
medical diagnoses, or successful allopathic therapies. Such Case one
complaints are common and can be major sources of dis- A 54-year-old, medically retired, fighter pilot instructor had
satisfaction and decreased quality of life for patients. How- an 8-year history of pain in the right neck radiating to the
ever, these premorbid states fit well within the acupuncture scapula. His symptoms had started insidiously, related to
diagnostic and therapeutic paradigms, which focus on exposure to high G-forces, but escalated after a series of
preventive care and promotion of homeostasis and vitality parachute bailouts from crashing planes. Treatments for
rather than reversal of frank end organ dysfunction. pain before the presentation included six surgeries over the
Aesthenic states and autonomic dysregulation dis- right neck and scapular region, including muscle and
orders are two types of functional disturbances particularly tendon releases and nerve transections, and an extensive
relevant to pain medicine. Aesthenic states include chronic trial of multiple medications including anticonvulsants,
ill-defined fatigue, dysthymia and mild depression, and muscle relaxants, tricyclic antidepressants, a number of the
diminished libido. Autonomic dysregulation may manifest newer selective antidepressants, repeated trigger point injec-
Acupuncture in Pain Medicine: An Integrated Approach to the Management of Refractory Pain • Ahadian 449
tions, physical therapy, chiropractics, and massage. Four Dietary modifications and hormone therapy had failed to
years before this patient’s presentation, chronic opiate reduce the intensity and frequency of the headaches.
therapy had been initiated with some improvement. How- Numerous triptans had been administered and failed
ever, his treatment course had been stormy. He had been secondary to adverse effects. She was taking 120 mg of
through several opiate rotations, each time requiring rapid propranolol daily for migraine prophylaxis. Intranasal
escalation of the drug (highest daily doses: 600 mg of stadol spray had been prescribed as abortive therapy, but at
morphine, 500 mg of oxycodone, 150 mg of methadone, the time of presentation the dose had escalated to an hourly
and 150 µg/h of fentanyl transdermal patches). Further esca- basis, causing rebound headaches.
lation of opiates had been limited by side effects. The patient underwent eight weekly acupuncture treat-
Two years after the initial institution of chronic opiate ments. These included a combination of body and auric-
therapy, the patient was referred for a trial of acupuncture. He ular electroacupuncture. At the time of the first treatment
complained of inadequate pain control interfering with his session, the intranasal stadol spray was discontinued and
personal and social activities. His sleep hygiene was poor. He the patient was administered 40 mg of controlled-release
described a constant, sharp, burning pain at the base of oxycodone daily in two divided doses. The patient was
his neck on the right side. The pain ranged from 7 to 10 on a given the option to return to the clinic for additional
scale of 0 to 10. He also described muscle spasms in the auricular acupuncture treatments if she developed signs or
same region, which interfered with his ability to concentrate, symptoms of opiate withdrawal or further escalation of
work, or sleep. His physical examination was remarkable headaches. She exercised this option twice, once during the
for taut bands of muscle spasm involving the right cervical first week of treatment and once during the second week.
paraspinous muscles, the scalenes, the levator scapulae, By the eighth week of treatment, the frequency of head-
the rhomboids, and the erector spinae muscles in the aches reduced to two episodes each week on the average,
upper to-mid thoracic region. His surgical scars were well and the intensity had decreased substantially. The patient
healed. There were patchy areas of hypoesthesia and analgesia did not miss any more days of work.
related to the surgical procedures in his right neck and upper
back region. The active range of motion of the cervical spine Case three
was moderately decreased with respect to extension, right-side A 56-year-old woman had post-thoracotomy syndrome,
bending, and right rotation. His medications included 480 which occurred as an iatrogenic consequence of laporoscopic
mg of morphine daily, 900 mg of gabapentin daily, 150 mg of nissenfundoplication that was complicated by esophageal
trazadone at bedtime, and 20 mg of citalopram daily. perforation, mediastinitis, and pleuritis; it required chest
The patient underwent an initial course of 10 weekly tube placement and prolonged mechanical ventilation.
electroacupuncture sessions. The treatments were selected Her care before this presentation included intercostal nerve
based on the French energetics system of acupuncture [4] blocks, radiofrequency neurotomy, transcutaneous nerve
and included points on the extremities and the local region. stimulation, and medication management including mor-
The frequency of subsequent maintenance treatment ses- phine, methadone, gabapentin, mexiletene, baclofen,
sions was gradually reduced to once monthly. Throughout amytriptilene, and trazadone. She complained of severe pain
the initial 10-week course of therapy, the morphine dose was along the lateral and anterior chest wall. The pain included
reduced to 300 mg daily. Pain scores dropped to 3 to 6 on a a sharp shooting component and a more diffuse, deep,
scale of 0 to 10. Subjectively, the patient remained constant pain. The pain was not related to respirations, but
satisfied with this level of pain relief. The muscle spasms was exacerbated by movements of the left arm. Findings on
were no longer present continuously, but heavy her physical examination included reproduction of sharp
physical activities such as working in the backyard still led to pain by percussion over the well-healed chest tube scar along
increased spasms. His sleep also improved dramatically. the anterior axillary line on the left side, and diffuse myo-
His use of trazadone was changed to an as-needed basis. fascial tenderness in the surrounding region. The myofascial
He has continued his monthly treatments for the past tenderness involved the pectoralis major and minor, the
2 years, with no change in his medication doses or the need latissimus dorsi, the subscapularis, the teres muscles, the
for opiate rotation. intercostals, and the serratus anterior. She also complained
bitterly of fatigue, insomnia, and loss of libido, which
Case two were entirely new for her since her surgery. Methadone and
A 44-year-old school librarian with migraine headaches gabapentin were helpful, but caused daytime somnolence
complained that she could no longer afford to pay her $300 and worsening of her fatigue and loss of libido. At the time of
monthly co-pay for intranasal stadol spray, which was being her presentation, her medications included 40 to 60 mg of
prescribed for abortive therapy for her headaches. The methadone daily, 1800 mg of gabapentin daily, and 150 mg
migraines primarily occurred around her menses for most of of trazadone at bedtime.
her adult life. However, throughout the past 3 to 4 years, in Acupuncture treatment began with 10 weekly sessions.
conjunction with early menopause, the headaches had During this time, the dose of methadone was reduced to 10
escalated in severity and had become a daily occurrence. to 20 mg daily and the gabapentin was reduced to 900 mg
450 Anesthetic Techniques in Pain Management
daily. There were many episodes in which the patient 5. Gideon L: Acupuncture: clinical trials in the horse.
would forget to take her methadone because her pain level J Am Vet Med Assoc 1977, 170:220–224.
6. Wright M, McGrath CJ: Physiologic and analgesic effects
was negligible. The patient stated that for the first time of acupuncture in the dog. J Am Vet Med Assoc 1981,
since her surgery, she “felt like her old self again.” She 178:502–507.
began doing arts and crafts again, which was an important 7. Clifford DH, Lee MO, Lee DC: Cardiovascular effects of
hobby for her that she had abandoned postoperatively. The atropine on acupuncture, needling with electrostimulation,
at Tsu San Li (ST–36) in dogs. Am J Vet Res 1977, 38:845–849.
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Nouveau traite d'acupunture. Edited by Niboyet JE. Maisonneuve:
for minor fluctuations in dosages from time to time, her Moulins-les-Metz; 1979:247–277.
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Throughout the past three decades, traditional Western of "zusanli" point in activating nucleus raphe magnus.
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13. Lichtman AH, Fanselow MS: Opioid and nonopioid con-
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