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Acupuncture in Pain Medicine:

An Integrated Approach to the


Management of Refractory Pain
Farshad M. Ahadian, MD

Address acupuncture, one of the subspecialties in medical acupunc-


Center for Pain and Palliative Medicine, University of California, ture and a powerful tool in the armamentarium of the pain
San Diego, 9500 Gilman Drive, #0924, La Jolla, CA 92093-0924, USA. physician. Three case reports are discussed to demonstrate
E-mail: fahadian@ucsd.edu
some practical uses of these modalities and their inte-
Current Pain and Headache Reports 2002, 6:444–451
Current Science Inc. ISSN 1531–3433
gration into a busy clinical practice.
Copyright © 2002 by Current Science Inc.

Acupuncture in the West


As the acupuncture nomenclature permeates medical
Knowledge of acupuncture made its way into the Western
literature, the artificial barriers to integration
world as early as the 17th century, beginning with the
of acupuncture and allopathic medicine are disappearing.
presence of Jesuit missionaries in China. However, because
More patients are looking to their physicians for
of its clash with the existing Western physiologic paradigm,
guidance on how to incorporate acupuncture into
Western scientists dismissed it as working through
their health care, and pain physicians are accepting
suggestion, distraction, or hypnosis. Despite this, interest
the challenge. Similar to allopathic medicine, acupuncture
in acupuncture persisted in the shadows of allopathic
is an intricate diagnostic and therapeutic system. However,
medicine; however, because of the lack of scientific
for practicing physicians, mastery of the skills necessary
support, the evidence for acupuncture in the treatment of
for safe and effective treatment of many conditions is
illness remained anecdotal until the 1970s.
well within reach. Used in an integrated medical
The first report regarding acupuncture that had wide-
model, acupuncture is well suited to deal with many
spread exposure in the United States was by James Reston,
of the functional problems that allopathic medicine
a journalist for the New York Times (The New York Times
is not equipped to address. The result is patient and
July 26, 1971, 1:6). Reston had required an emergency
physician satisfaction.
appendectomy while he was in China. His postoperative
pain and ileus had been treated with acupuncture, and
he was impressed enough with the results that he wrote
Introduction about it. The impact was so widespread that even the
Acupuncture originated in China more than 2000 years Internal Revenue Service accepted acupuncture as a legit-
ago, and it is one of the oldest and most commonly prac- imate medical expense. In 1971, Dr. E. Grey Dimond
ticed medical disciplines in the world. In 1993, the US Food and Dr. Paul Dudley White were invited to the People’s
and Drug Administration estimated that Americans made Republic of China. In December of 1971, the Journal of the
9 to 12 million visits each year to acupuncture practitioners American Medical Association published “Acupuncture
and spent as much as $500 million on acupuncture treat- Anesthesia,” which was Dr. Dimond’s report of this trip
ments [1]. In the past two decades, acupuncture popularity [3]. The report included his first-hand observations of
has grown dramatically in the United States. In 1995, an multiple surgeries using acupuncture anesthesia. These
estimated 10,000 nationally certified acupuncturists reports captivated the US medical community and marked
were practicing in the United States. That number was the beginning of the scientific exploration of acupuncture
estimated to have doubled by the year 2000. An estimated in the United States. Because of the early reports of
one third of certified acupuncturists in the United States are acupuncture, anesthesia, and analgesia, the Western
medical doctors [2]. medical community has been preoccupied with the use of
This article begins with a review of the evolution of acupuncture in pain control. However, acupuncture is a
acupuncture in the West and its integration into allopathic complete system of medicine that is equally applicable to
medicine. The discussion then moves on to auricular all aspects of healing [4].
Acupuncture in Pain Medicine: An Integrated Approach to the Management of Refractory Pain • Ahadian 445

Figure 1. Schematic representation of


the peripheral and central nervous
system pathways involved in acupuncture.

State of the Science acupuncture point. Senelar [9] described the acupuncture
The strongest initial evidence for the validity of acupunc- point to be located in a vertical column of loose connective
ture was its efficacy in veterinary medicine and, sub- tissue, surrounded by denser connective tissue of the skin.
sequently, in human infants, populations in which Within the column of loose connective tissue, a lymphatic
suggestibility and placebo effects could not explain the trunk is coupled with an arteriole and a vein. The lympho-
observed results [5–7]. Subsequently, it was shown in vascular bundle is surrounded by a rich plexus of unmyeli-
animals, and later in humans, that real acupuncture caused nated cholinergic nerve fibers. The epidermis thins at the
analgesia, and sham acupuncture did not. The initial stud- surface of the acupuncture point and there is modification
ies were conducted on experimental pain models in which of the collagen fibers (Fig. 1). Insertion of an acupuncture
placebo had a minimal impact relative to chronic pain needle primarily activates the A-δ fibers [10]. The A-β fibers
disorders. Several controlled trials of patients with chronic also may be activated. Deeper insertion may stimulate group
pain also have shown a statistically significant difference II and group III fibers. Calcitonin gene-related peptide
between acupuncture and placebo conditions [8]. Indeed, (CGRP) and substance P are released locally with associated
more is known about the mechanisms of action of acu- vasodilation and increased tissue temperature. At the level of
puncture than many pharmaceutic and physical agents in the dorsal horn of the spinal cord, interneurons segmentally
routine use. Examples include the mechanism of action of release dynorphin and enkephalin [11]. At the level of the
inhaled anesthetics in general anesthesia and the mecha- brain stem, the reticular formation (RF), the nucleus raphe
nisms of action of anticonvulsants or spinal cord stimula- magnus (NRM), and the nucleus reticularis magnocellularis
tors used for chronic pain states. (NRM) may be activated [12]. These nuclei trigger descend-
Throughout the past three decades, several lines of evi- ing serotonergic and noradrenergic pathways that synapse
dence have been explored to gain insight into the scientific onto dorsal horn neurons, causing the release of enke-
basis of acupuncture. The findings have been summarized phalin. The periaqueductal grey (PAG) at the level of the
in chronologic order in Table 1. midbrain also has descending enkephalinergic input. These
fibers activate the NRM and the reticularis magnocellularis
nuclei as they descend from the midbrain to synapse onto
Acupuncture Physiology the dorsal horn neurons in the spinal cord. Dynorphin and
In 1979, the basic morphologic structure of an acupuncture enkephalin are the endogenous opiates generally found
point was described by Senelar [9] based on the statistical from the spinal cord to the midbrain. In contrast, at the
analysis of a large number of histologic sections of acupunc- level of the hypothalamic pituitary axis, β-endorphin is the
ture points in rabbits, cats, mice, and human cadavers. primary neuropeptide. Through these endorphinergic
Although the components of the acupuncture point pathways, the hypothalamus has widespread influence
structure are not unusual in themselves, they are con- throughout the central nervous system, including the
centrated and organized in a distinctive fashion to form the periventricular nuclei of the thalamus, the nucleus acum-
446 Anesthetic Techniques in Pain Management

Table 1. The scientific basis of acupuncture


Line of evidence Findings References
1.Bioelectrical properties 1. Acupoints have a lower electrical resistance than Niboyet [33,34]; Rabischong et al.
of acupoints the surrounding skin [35]; Roppel and Mitchell [36];
2. The electrical resistance between two acupuncture Hyvarinen and Karlsson[37]
points on the same classically described acupuncture
channel is lower than the resistance between two
acupuncture points on different acupuncture channels
3. The points and pathways of lowered electrical resistance
are bilaterally symmetrical, except for the anterior
and posterior midline.
2. Propagated sensation 1. Nondermatomal Bossy [38]; Eckman [39];
along acupuncture channels 2. Dependent on A-delta and C fibers MacDonald [40]; Kendall [41]
3. Blocked by local anesthetics, mechanical pressure, and ice
3. Technetium-99 1. Technetium-99 injection into acupoints reveals linear De Vernejoul et al. [42,43];
tracer studies spread topographically analogous to classically described Darras [44,45]
acupuncture channels.
2. Technetium-99 injection into non-acupuncture points
shows a centrifugal diffusion pattern
3. The rate of Technetium-99 linear spread increases
when the acupoint is stimulated
4. Rates of Technetium-99 linear spread do not correlate
with vascular or lymphatic circulation rates
4. Electrical propagation 1. Resistance to current passed between acupuncture points Mussat [46]; Reichmanis
along channels on the same classically described channel is less than et al. [47–49]
non-acupuncture points
2. If a current is introduced between two needles at one end
of an acupuncture channel after a latency period, a current
is detected between two needles inserted into the other
end of the same acupuncture channel
5. Morphologic studies 1. Approximate surface area is 1–5 mm Senelar [9]; Melzack et al. [50];
of acupuncture points 2. Points are commonly located in surface depressions Dung [51]; Terral [52];
along cleavage planes between muscles Bossy and Sambuc [53]
3. Most points may be identified by palpation and
may be hypersensitive
4. Histologically described as a column of loose, connective
tissue containing an arteriole, vein, lymphatic vessel,
myelinated nerves, and a rich plexus of unmyelinated,
possibly autonomic fibers, which are surrounded by thick,
dense connective tissue
6. Naloxone reversibility 1. Demonstrated in multiple mammalian organisms, Pomeranz et al. [54,56,58];
of acupuncture analgesia including humans Mayer et al. [55]; Cheng and
Pomeranz [57]
7. Increased CSF and 1. Demonstrated in multiple mammalian organisms, Sjolund et al. [59]; Clement-Jones
serum endorphin levels including humans et al. [31,60]; Hardebo et al. [61]
in response to acupuncture
8. fMRI 1. Acupuncture has regionally specific, quantifiable effects on Hui et al. [64]
relevant brain structures
2. fMRI appears to be a valid tool for studying the
CNS pathways affected by acupuncture
9. PET 1. Acupuncture has regionally specific, quantifiable effects
on relevant brain structures
2. PET imaging appears to be a valid tool for studying
the CNS pathways affected by acupuncture
CNS—central nervous system; CSF—cerebrospinal fluid; fMRI—functional magnetic resonance imaging; PET—positron emission tomography.

bens of the limbic system, the amygdala and diencephalon, nucleic acid also have been demonstrated to increase within
and the PAG [13–15]. The hypothalamic-pituitary-adrenal the spinal cord and higher centers after acupuncture, indi-
axis also controls serum cortisol levels. Cholecystokinin cating early gene expression. This may explain the cumula-
octapeptide, c-fos, and proenkephalin messenger ribo- tive and prolonged effects of acupuncture [16–20].
Acupuncture in Pain Medicine: An Integrated Approach to the Management of Refractory Pain • Ahadian 447

Figure 3. Homuncular
arrangement of the
auricular reflex micro-
system originally
described by
Paul Nogier. An
inverted body is
topographically
represented on the
external auricle.

Figure 2. Schematic representation of the human external auricle


demonstrating its embryonic origin and rich neural innervation.
(CN V—cranial nerve V; CN X—cranial nerve X; C1, C2,
C3—first, second, and third cervical spinal nerves.)

Auricular Acupuncture Physiologic Basis of Auricular Acupuncture


Citations of treatments using points on the ear are found Auricular acupuncture is based on a reflex somatotopic
throughout the literature of many ancient cultures, system organized on the surface of the external ear (Fig. 3),
including Chinese and Persian medical writings and Egyp- which is one of many such microsystems in the body. The
tian tomb paintings. The Hippocratic writings discuss cau- speculative neuroanatomic model of this microsystem
terization and bleeding of the ear. Seventeenth and 18th consists of projections from visceral and somatic organs
century European medical publications reported the use of and their somatotopic projections onto a modulating
ear cautery to treat dental neuralgia and sciatica [4]. center in the brain. After arriving at this central modulating
The scientific exploration and systematic charting of the center, afferent signals from each organ trigger a change in
auricular correspondences were undertaken by Paul Nogier, the corresponding somatotopic focus on the surface of the
a French neurophysiologist, beginning in the early 1950s. ear. This change may be detected as a decreased sensory
Nogier’s teaching and publications were disseminated from threshold or as a decreased electrical resistance at the
France to Germany, and from Germany to China by way of somatotopic focus. Alternatively, stimulation of the
Japan. In the United States, the precision of the somatotopic somatotopic focus may modulate afferent signals from the
mapping was verified in a blinded experiment, showing corresponding organ (Gate Control Theory) or, through its
92% percent concordance between established medical effect on the central modulating center, trigger a change in
diagnoses and auricular diagnoses. Auricular acupuncture is the cerebral cortex or the end organ itself. The brain stem
a treatment system based on normalizing the body's pain reticular formation, with its inhibitory and excitatory influ-
and dysfunction through stimulation of points on the ences on ascending and descending sensory, motor, and
ear. Resulting amelioration of pain and illness is believed autonomic impulses, appears to be the most likely central
to be through the reticular formation and the autonomic modulating center. The auricular microsystem is useful as a
nervous system [21•]. diagnostic and therapeutic modality.
Auriculotherapy is a sophisticated discipline of acu-
puncture that can be studied to a refined level of precision.
Neuroanatomy of the External Ear However, adequate skills necessary for safe and effective
The external ear develops from embryonic gill plates. It treatment of more limited problems may be learned
is made of tissue from each of the three embryonic layers: quickly and are well within the reach of the allopathic
ectoderm, mesoderm, and endoderm. It has a dense and physician. The techniques may be used as a sole treatment
complex nervous innervation, including the greater auricular or may be easily combined with concurrent therapies.
nerve (C1, C2, C3) auriculotemporal branch of the tri-
geminal nerve (CN V), which has sympathetic fibers, and the
auricular branch of the vagus nerve (CN X), which has Clinical Applications
par sympathetic fibers. The facial (CN VII) and glosso- Research shows that acupuncture is beneficial in treating a
pharyngeal (CN IX) nerves also provide minor contributions variety of health conditions [16,22,23,24•]. According to a
to the external auricle (Fig. 2). consensus panel of scientists from the National Institutes of
448 Anesthetic Techniques in Pain Management

Health, researchers, and practitioners who convened in as anxiety, sleep disturbances, and bowel dysfunction. It is
November, 1997, clinical studies have shown that acupunc- the rule, not the exception, for patients with chronic pain
ture is an effective treatment for nausea caused by surgical to have several of these symptoms simultaneously. Failure
anesthesia, cancer, and for dental pain experienced after to address these disturbances frequently leads to failure of
surgery. The panel also found that acupuncture is useful treatment despite appropriate and conscientious use of
when administered alone or when combined with conven- conventional therapies. Acupuncture offers a valuable tool
tional therapies to treat addiction, headaches, menstrual in the armamentarium of the pain physician for manage-
cramps, tennis elbow, fibromyalgia, myofascial pain, ment of functional disturbances.
osteoarthritis, lower back pain, carpal tunnel syndrome, and
asthma, and to assist in stroke rehabilitation [25]. Chronic opiate therapy
Administration of opiates for chronic pain states can no
longer be discounted as controversial and limited to patients
Acupuncture in Pain Medicine with terminal disease. It is now, and will continue to be,
There are three areas of pain medicine in which integration a critical part of the overall management of intractable
of acupuncture with allopathic medicine offers distinct malignant and non-malignant pain disorders. However,
advantages. These include musculoskeletal disorders, func- regardless of the route of administration (oral, parenteral, or
tional disturbances, and chronic opiate therapy. intrathecal), obtaining long-term success with these agents
poses numerous challenges. Among others, these challenges
Musculoskeletal disorders may include opiate side effects, physiologic tolerance,
Because of the ongoing demographic change facing medi- psychogenic dependence, and withdrawal. Combined
cine, musculoskeletal disorders will be a leading cause of opiate-acupuncture therapy is an invaluable technique for
disability and decreased quality of life for the elderly popu- achieving success with chronic opiate administration. Con-
lation. Because of advancing age and comorbidities, many of current acupuncture treatments may be considered adjuvant
these patients will not be surgical candidates or will choose therapy, a concept well known to pain physicians. Twenty
non-surgical alternatives. Furthermore, the untoward effects percent to 50% reduction in overall opiate requirement is
of analgesic medications are not well tolerated in this group not unusual after an initial course of acupuncture; the need
of patients; therefore, their options are few. Acupuncture for dose escalation may be substantially reduced or elimi-
offers an excellent choice. A recent prospective, controlled nated with acupuncture-maintenance therapy. Acupuncture
trial comparing acupuncture with no treatment for patients is a powerful tool for the management of situations in which
with advanced osteoarthritis of the knee who were awaiting opiate withdrawal is a central issue. This may occur when
total knee replacement showed a highly statistically signifi- changing from one opiate to another (opiate rotation),
cant difference between the groups. The acupuncture group or when opiate therapy is discontinued. In animal studies,
improved in walking, climbing stairs, and pain levels; the electroacupuncture has been shown to reduce withdrawal
control group deteriorated as time passed [26]. Although behavior by 50% [30]. For patients who are addicted to
knee osteoarthritis appears to be one of the best indications heroin, electroacupuncture suppressed the clinical features
for acupuncture, other common musculoskeletal disorders of withdrawal. In all of the patients who were observed,
such as cervical and lumbar facet disease, painful disorders successful treatment was associated with an increase in
of the hip joint, and myofascial pain syndrome also are cerebrospinal fluid met-enkephalin levels [31]. Auricular
appropriate indications [27–29]. electroacupuncture and naloxone have been used success-
fully to achieve rapid opiate detoxification in patients
Functional disturbances with chronic pain [32].
The term functional disturbances is used by many physicians
to describe subjective complaints that are rarely associated
with positive physical or laboratory findings, definitive Case Reports
medical diagnoses, or successful allopathic therapies. Such Case one
complaints are common and can be major sources of dis- A 54-year-old, medically retired, fighter pilot instructor had
satisfaction and decreased quality of life for patients. How- an 8-year history of pain in the right neck radiating to the
ever, these premorbid states fit well within the acupuncture scapula. His symptoms had started insidiously, related to
diagnostic and therapeutic paradigms, which focus on exposure to high G-forces, but escalated after a series of
preventive care and promotion of homeostasis and vitality parachute bailouts from crashing planes. Treatments for
rather than reversal of frank end organ dysfunction. pain before the presentation included six surgeries over the
Aesthenic states and autonomic dysregulation dis- right neck and scapular region, including muscle and
orders are two types of functional disturbances particularly tendon releases and nerve transections, and an extensive
relevant to pain medicine. Aesthenic states include chronic trial of multiple medications including anticonvulsants,
ill-defined fatigue, dysthymia and mild depression, and muscle relaxants, tricyclic antidepressants, a number of the
diminished libido. Autonomic dysregulation may manifest newer selective antidepressants, repeated trigger point injec-
Acupuncture in Pain Medicine: An Integrated Approach to the Management of Refractory Pain • Ahadian 449

tions, physical therapy, chiropractics, and massage. Four Dietary modifications and hormone therapy had failed to
years before this patient’s presentation, chronic opiate reduce the intensity and frequency of the headaches.
therapy had been initiated with some improvement. How- Numerous triptans had been administered and failed
ever, his treatment course had been stormy. He had been secondary to adverse effects. She was taking 120 mg of
through several opiate rotations, each time requiring rapid propranolol daily for migraine prophylaxis. Intranasal
escalation of the drug (highest daily doses: 600 mg of stadol spray had been prescribed as abortive therapy, but at
morphine, 500 mg of oxycodone, 150 mg of methadone, the time of presentation the dose had escalated to an hourly
and 150 µg/h of fentanyl transdermal patches). Further esca- basis, causing rebound headaches.
lation of opiates had been limited by side effects. The patient underwent eight weekly acupuncture treat-
Two years after the initial institution of chronic opiate ments. These included a combination of body and auric-
therapy, the patient was referred for a trial of acupuncture. He ular electroacupuncture. At the time of the first treatment
complained of inadequate pain control interfering with his session, the intranasal stadol spray was discontinued and
personal and social activities. His sleep hygiene was poor. He the patient was administered 40 mg of controlled-release
described a constant, sharp, burning pain at the base of oxycodone daily in two divided doses. The patient was
his neck on the right side. The pain ranged from 7 to 10 on a given the option to return to the clinic for additional
scale of 0 to 10. He also described muscle spasms in the auricular acupuncture treatments if she developed signs or
same region, which interfered with his ability to concentrate, symptoms of opiate withdrawal or further escalation of
work, or sleep. His physical examination was remarkable headaches. She exercised this option twice, once during the
for taut bands of muscle spasm involving the right cervical first week of treatment and once during the second week.
paraspinous muscles, the scalenes, the levator scapulae, By the eighth week of treatment, the frequency of head-
the rhomboids, and the erector spinae muscles in the aches reduced to two episodes each week on the average,
upper to-mid thoracic region. His surgical scars were well and the intensity had decreased substantially. The patient
healed. There were patchy areas of hypoesthesia and analgesia did not miss any more days of work.
related to the surgical procedures in his right neck and upper
back region. The active range of motion of the cervical spine Case three
was moderately decreased with respect to extension, right-side A 56-year-old woman had post-thoracotomy syndrome,
bending, and right rotation. His medications included 480 which occurred as an iatrogenic consequence of laporoscopic
mg of morphine daily, 900 mg of gabapentin daily, 150 mg of nissenfundoplication that was complicated by esophageal
trazadone at bedtime, and 20 mg of citalopram daily. perforation, mediastinitis, and pleuritis; it required chest
The patient underwent an initial course of 10 weekly tube placement and prolonged mechanical ventilation.
electroacupuncture sessions. The treatments were selected Her care before this presentation included intercostal nerve
based on the French energetics system of acupuncture [4] blocks, radiofrequency neurotomy, transcutaneous nerve
and included points on the extremities and the local region. stimulation, and medication management including mor-
The frequency of subsequent maintenance treatment ses- phine, methadone, gabapentin, mexiletene, baclofen,
sions was gradually reduced to once monthly. Throughout amytriptilene, and trazadone. She complained of severe pain
the initial 10-week course of therapy, the morphine dose was along the lateral and anterior chest wall. The pain included
reduced to 300 mg daily. Pain scores dropped to 3 to 6 on a a sharp shooting component and a more diffuse, deep,
scale of 0 to 10. Subjectively, the patient remained constant pain. The pain was not related to respirations, but
satisfied with this level of pain relief. The muscle spasms was exacerbated by movements of the left arm. Findings on
were no longer present continuously, but heavy her physical examination included reproduction of sharp
physical activities such as working in the backyard still led to pain by percussion over the well-healed chest tube scar along
increased spasms. His sleep also improved dramatically. the anterior axillary line on the left side, and diffuse myo-
His use of trazadone was changed to an as-needed basis. fascial tenderness in the surrounding region. The myofascial
He has continued his monthly treatments for the past tenderness involved the pectoralis major and minor, the
2 years, with no change in his medication doses or the need latissimus dorsi, the subscapularis, the teres muscles, the
for opiate rotation. intercostals, and the serratus anterior. She also complained
bitterly of fatigue, insomnia, and loss of libido, which
Case two were entirely new for her since her surgery. Methadone and
A 44-year-old school librarian with migraine headaches gabapentin were helpful, but caused daytime somnolence
complained that she could no longer afford to pay her $300 and worsening of her fatigue and loss of libido. At the time of
monthly co-pay for intranasal stadol spray, which was being her presentation, her medications included 40 to 60 mg of
prescribed for abortive therapy for her headaches. The methadone daily, 1800 mg of gabapentin daily, and 150 mg
migraines primarily occurred around her menses for most of of trazadone at bedtime.
her adult life. However, throughout the past 3 to 4 years, in Acupuncture treatment began with 10 weekly sessions.
conjunction with early menopause, the headaches had During this time, the dose of methadone was reduced to 10
escalated in severity and had become a daily occurrence. to 20 mg daily and the gabapentin was reduced to 900 mg
450 Anesthetic Techniques in Pain Management

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