Semester 2 Sesi 2019-2020 Fakulti Sains & Teknologi, UKM

SINOPSIS KURSUS

KOD KURSUS : STBP1023

NAMA KURSUS : Cell Biology

JAM KREDIT : 3

JAM PERTEMUAN : Kuliah (33 jam), Tutoran (5 jam)

PRASYARAT : Tiada

PENSYARAH
• Dr. Nur Hazlin Hazrin Chong (HHC)
• Dr Babul Airianah Othman (BAO)
• Dr Shevin Rizal Feroz (SRF)
• Dr. Shazilah Kamaruddin (SK)*

* Penyelaras (shazilah@ukm.edu.my)

KAEDAH PENILAIAN

Kuiz : 25%
Ujian Akhir : 20%
Tugasan : 55%

SINOPSIS :

Kursus ini membincangkan struktur dan fungsi sel secara mendalam. Huraian termasuk
hubungan struktur-fungsi organel seperti mitokondria, kloroplas dan ribosom. Perbincangan
termasuk struktur membran, jalinan endoplasma dan dinding sel bakteria serta tumbuhan.
Makromolekul dalam sel seperti protein, polisakarida dan lipid juga dibincangkan. Dari segi
fungsi, sistem penimbalan sel serta sistem pengangkutan merupakan tujahan awal. Kinetik
tindak balas enzim dan peranan biopemangkin ini dalam metabolisme sel juga akan
dibincangkan. Ini diikuti dengan huraian mengenai prinsip termodinamik dan sistem penjanaan
tenaga sel. Perbincangan tentang metabolisme tenaga meliputi proses fotosintesis dan
fotorespirasi dalam tumbuhan serta penjanaan ATP dari karbohidrat dan lipid dalam sistem
haiwan.

This course presents an in-depth discussion on the structure and functions of the cell. This
includes the structure – function relationship of various organelles i.e. mitochondria,
chloroplasts and ribosomes. The discussion includes membrane structure, endoplasmic
reticulum and the cell walls of plants and bacteria. Cellular macromolecules such as proteins,
polysaccharides and lipids will be elaborated. Topics for cell function include the cell buffering
system and cellular transport mechanisms. Kinetics of enzyme-catalysed reactions and the roles
of enzymes in cell metabolism will also be dealt with. This is followed by discussions on the
principles of thermodynamics and the cell energy system. Aspects of energy metabolism covered
include photosynthesis and photorespiration in plants and the production of ATP from
carbohydrates and lipids in the animal system.

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Semester 2 Sesi 2019-2020 Fakulti Sains & Teknologi, UKM

BACAAN ASAS :

Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. & Walter, P. 2014. Molecular biology of
the cell. 6th Edition. New York: Garland Science.
Campbell, M. K. & Farrell, S. O. 2011. Biochemistry. 7th Edition. USA: Brooks/Cole Cengage
Learning.
Karp, G. 2013. Cell and molecular biology: Concepts and experiments. 7th Edition. New York: John
Wiley & Sons Inc.
Nelson, D.L. & Cox, M.M. 2012. Lehninger principles of biochemistry. 6th Edition. New York:
W.H. Freeman.
Voet, D., Voet, J.G. & Pratt, P.W. 2010. Fundamentals of biochemistry. 4th Edition New York: John
Wiley & Sons Inc.

Senarai Hasil Pembelajaran Kursus :

HPK 1 Berkebolehan menganalisis dan menghubungkaitkan struktur serta fungsi pelbagai

organel dan komponen subsel lain
Ability to analyse and relate structure-function relationship of various organelles and
other sub-cellular components
HPK 2 Berkebolehan menginterpretasi asas kimia kehidupan berdasarkan korelasi antara
struktur biomolekul seperti protein, polisakarida dan lipid dengan sifat fiziko-kimia
dan fungsi biologi masing-masing serta peranan penimbalan dalam proses fisiologi
Ability to interpret the chemical basis of life based on the correlation of structures of
biomolecules such as proteins, polysaccharides and lipids with their respective
physico-chemical properties and biological functions, and the role of buffering in
physiological processes
HPK 3 Berkebolehan untuk mengekstrapolasi ciri-ciri pemangkinan dan kinetik enzim tindak
balas unisubstrat serta kepentingan isoenzim dan koenzim dalam tindak balas
Ability to extrapolate the catalytic and kinetic properties of enzymes in unisubstrate
reactions; and the importance of isoenzymes and coenzymes in enzyme catalysis
HPK 4 Berupaya menginterpretasi bagaimana metabolisme karbohidrat dan lipid digunakan
untuk menjanakan ATP dalam sistem haiwan serta menganalisis fotosintesis di
samping menghayati peranan kitar glioksilat dalam glukoneogenesis
Ability to interpret how metabolisms of carbohydrate and lipid are harnessed to
generate ATP in the animal system as well as analyse photosynthesis in addition to
appreciating the role of the glyoxylate cycle in gluconeogenesis

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Semester 2 Sesi 2019-2020 Fakulti Sains & Teknologi, UKM

Hasil Pembelajaran Program (HPP)* /Kerangka Kelayakan Malaysia (MQF)**

HPP1 Berkeupayaan memahami konsep utama biokimia, biologi molekul dan bidang biosains
berkaitan
HPP2 Mempunyai keupayaan memperoleh dan menggunakan kemahiran amali dan kaedah
biokimia, biologi molekul dan bidang biosains berkaitan
HPP3 Berkemampuan menjalankan penyelidikan dengan beretika, amanah dan profesional
serta mewujudkan kesedaran isu keselamatan produk dan prosidur yang berisiko
terhadap kesihatan awam dan persekitaran
HPP4 Mempunyai kesedaran mengenai isu etika dan isu semasa dalam bidang biokimia,
biologi molekul dan bidang biosains berkaitan
HPP5 Mempunyai kebolehan berkomunikasi secara saintifik dan bekerjasama secara
berkumpulan
HPP6 Berkemampuan mengenal pasti, menganalisis dan menyelesaikan masalah secara
saintifik
HPP7 Berupaya mencari, memperoleh dan menggunakan maklumat kepustakaan saintifik
biokimia, biologi molekul dan bidang biosains berkaitan serta mempunyai kemahiran
untuk melakukan pembelajaran berterusan
HPP8 Mempunyai kebolehan mengintegrasikan kemahiran keusahawanan dan pengurusan
dalam ilmu biokimia
*Diisi oleh Fakulti
**Diisi oleh Pusat Citra Universiti (PCU) dan Pusat Pembangunan Keusahawanan & Eks (UKM-
CESMED)

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 Semester 2 Sesi 2019-2020 Fakulti Sains & Teknologi, UKM

PERINCIAN KULIAH MENGIKUT MINGGU DAN TAJUK

Week Topics Hours Lecturer

1 Introduction

Cell as the basic unit of life

• Overview of cell structure and functions
• Techniques to study cell structure and function (microscopy, cell 1 HHC
fractionation) 14/2

1-2 Structure and functions of cells

• Organelles (mitochondria, chloroplasts, ribosomes, nuclei, Golgi
Complex etc) 2 HHC
• Other sub-cellular components (bacterial and plant cell walls, 18/2, 19/2
cytoskeleton)

2-3 Membrane Biology

• Structure, composition and models of membranes 3 HHC
• Transport across membranes 21/2, 25/2, 26/2

3-5 Macromolecules in cells

BAO
• Structure, properties and functions of polysaccharides and lipids 3 28/2, 3/3, 4/3

• Structure, properties and functions of proteins BAO

2 6/3, 10/3

Tutorials 1 11/13
5-6 Cell buffering system
• Characteristics of water, acids and bases 3 HHC
• Properties of buffers, physiological buffers 13/3, 17/3, 28/4

Tutorials 1 5/5
6-7 Bioenergetics
• Principles of thermodynamics
• Involvement of ATP in coupled reactions 2 SK
8/5, 8/5

8 Mid Semester Break/COVID19 Occasional Holiday 21/3 – 27/4/2020

QUIZ 1 TBA
9-10
Enzymatic reactions in cells
• Enzyme classification and thermodynamics of catalysis (activation energy, SK
transition state theory) 3 12/5, 15/5, 15/5
• Catalytic characteristics (specificity and reaction models)
• Factors influencing enzyme reactions

11-12 • Kinetics of unisubstrate reactions : SK

Michaelis Menten equation, significance of Km and Vmax values, 2 19/5, 22/5
Lineweaver-Burk plot
• Roles of isoenzymes and coenzymes

Tutorials 1 SK
OUTSIDE LECTURE
TIME (TBA)

10 – 13 Energy metabolism and ATP synthesis SRF

• Glycolysis and gluconeogenesis 6 22/5, 5/6, 5/6, 8/6,
• TCA cycle 12/6, 12/6
• Respiratory chain and oxidative phosphorylation

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 Semester 2 Sesi 2019-2020 Fakulti Sains & Teknologi, UKM

• -oxidation of fatty acids

• Shuttle systems 3 16/6, 19/6, 19/6

Tutorials 1 OUTSIDE LECTURE

TIME (TBA)
14 - 15
BAO
• Photosynthesis and photorespiration 3 23/6
• Glyoxylate cycle 26/6, 26/6

Tutorials
1 OUTSIDE LECTURE
TIME (TBA)

Final Test 29th June-17th July

(TBA)

Total lecture hours 33

Total tutorial hours 5

JADUAL KULIAH

Selasa 0800 – 0900 SECARA MAYA

Jumaat 0800 – 0900 SECARA MAYA
Jumaat 1100 – 1200 SECARA MAYA

01/05/2020 Jumaat Hari Pekerja

24/05/2020 Ahad Hari Raya Puasa
25/05/2020 Isnin Hari Raya Puasa (Hari Kedua)

Sesi Pembelajaran 10 Feb - 17 Mac 2020 5 minggu

Cuti Peristiwa &

Cuti Pertengahan Semester 18 Mac - 26 April 2020 6 minggu

Sesi Pembelajaran 27 April - 22 Mei 2020 4 minggu

Cuti Perayaan 23 Mei - 2 Jun 2020 1 minggu

Sesi Pembelajaran 3 Jun - 28 Jun 2020 4 minggu

Peperiksaan 29 Jun - 17 Julai 2020 3 minggu

Cuti Semester 2 18 Julai - 31 Ogos 2020 6 minggu