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journal of dentistry 38 (2010) 875–881

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Eight-year outcome of posterior inlay-retained all-ceramic


fixed dental prostheses

S. Harder a, S. Wolfart b, S. Eschbach a, M. Kern a,*


a
Department of Prosthodontics, Propaedeutics and Dental Materials, Christian-Albrechts University, Arnold-Heller Str. 16,
24105 Kiel, Germany
b
Department of Prosthodontics, RWTH University, Pauwelsstr. 30, 52074 Aachen, Germany

article info abstract

Article history: Aim: The main goal of this prospective clinical study was to evaluate the outcome of inlay-
Received 6 March 2010 retained fixed dental prostheses (FDPs) made from heat-pressed lithium-disilicate glass-
Received in revised form 28 July 2010 ceramic.
Accepted 29 July 2010 Methods: Forty-five FDPs were placed in 42 patients (21 women, mean age 36.1 years and 21
men, mean age 42.0 years). The FDPs replaced 4 premolars and 19 molars in the maxilla and
4 premolars and 18 molars in the mandible. Preparations were performed in accordance
Keywords: with general principles for ceramic inlay restorations. Five of the 45 FDPs were hybrid-
Clinical investigation retained restorations, i.e. one abutment tooth with an inlay retainer and one with a full
Survival crown retainer.
Inlay-retained fixed dental All FDPs were pressed in one piece using lithium-disilicate ceramic (IPS e.max Press,
prosthesis Ivoclar Vivadent). The minimum dimensions for the proximal connector were 4 mm in
All-ceramic height and 4 mm in width (16 mm2) with a minimum occlusal ceramic thickness of 1.5 mm.
Lithium-disilicate ceramic The surfaces of the inlay retainer were conditioned by etching with hydrofluoric acid 5% and
silane application. Standard adhesive luting techniques were performed using a dentin
adhesive (Syntac Classic, Ivoclar Vivadent) and a resin composite (Variolink II, Ivoclar
Vivadent). Clinical follow-up examinations were performed annually.
Results: The mean observation periods were 70 months (minimum 4, maximum 123
months). Twenty-seven FDPs (60%) failed during the observation period and had to be
replaced. The Kaplan–Meier survival rate for inlay-retained FDPs was 57% after 5 years and
38% after 8 years, while for hybrid-retained FDPs it was 100% after 5 and 60% after 8 years.
Conclusions: Inlay-retained FDPs made from lithium-disilicate ceramic present a high clini-
cal failure rate and therefore cannot be recommended.
# 2010 Elsevier Ltd. All rights reserved.

1. Introduction restorations, but also for fixed dental prostheses (FDPs) in the
posterior teeth region.
Full crown preparation always presents a risk to pulp vitality The use of box-shaped preparation forms for the support of
and may lead to pulp reactions in the long term.1 Approxi- inlay-retained FDPs might be the intended consequence if
mately 63–73% of the coronal tooth structure is removed when caries activity is low and only a single tooth has to be replaced.
teeth are prepared for all-ceramic crowns.2 Therefore it First promising attempts to use inlays as retainers for metal-
seemed desirable to adapt the type of abutment preparation ceramic resin-bonded FDPs in the posterior teeth region were
to avoid loss of sound tooth structure, not only for single tooth made by Stokholm and Isidor3 in 1996 and Serdar Cotert and

* Corresponding author. Tel.: +49 431 597 2874; fax: +49 431 597 2860.
E-mail address: mkern@proth.uni-kiel.de (M. Kern).
0300-5712/$ – see front matter # 2010 Elsevier Ltd. All rights reserved.
doi:10.1016/j.jdent.2010.07.012
876 journal of dentistry 38 (2010) 875–881
[(Fig._1)TD$IG]

Fig. 1 – Preparation design for three-unit inlay-retained FDP in the left mandible and for hybrid-retained FDP in the right
mandible and related master cast. Three-unit inlay-retained FDP for the replacement of a second premolar in occlusal-
lingual view. FDPs in situ immediately after luting (left to right/top to bottom).

Ozturk4 in 1997. Today the demand for metal-free restorations conditions and were in need of one or two three-unit FDPs but
with the desirable qualities such as aesthetics close to the had an otherwise sufficiently restored dentition.
natural teeth and additional superior biocompatibility, leads Informed consent for the study was obtained from all
to the consideration whether all-ceramic inlay-retained FDPs subjects on a written form approved by the Ethical Committee
are a viable treatment option for the posterior region. of the Medical Faculty of the Christian-Albrechts University at
The outcome of all-ceramic inlay-retained FDPs has been Kiel. The edentulous space had to be equal or smaller than the
investigated in vivo5–7 and in vitro8–12. In vitro investigations width of a molar. The bone level of the vital abutment teeth
regarding the fracture strength of three-unit inlay-retained
FDPs made from heat-pressed lithium-disilicate ceramic and
[(Fig._2)TD$IG]
yttrium-oxide partially stabilized zirconia were promising. But
for the clinical use of all-ceramic material for inlay-retained
restorations only short-term data are available to the present
time.5–7 The aim of the present study therefore was to assess
the intermediate clinical outcome of an heat-pressed lithium-
disilicate glass-ceramic for the use in inlay-retained 3-unit
FDPs when adopted with a standardized protocol concerning
preparation technique, restoration design and luting proce-
dure (Figs. 1 and 2).

2. Materials and methods

2.1. Study design

Patients referred to the Department of Prosthodontics,


Propaedeutics and Dental Materials of the Christian-Albrechts
University, Kiel, Germany with the need for a 3-unit FDP were Fig. 2 – Same FDPs as shown in Fig. 1, after 96 months
selected for the study. All patients were in good health observation time.
journal of dentistry 38 (2010) 875–881 877

had to correspond to at least two-thirds of the root length with necessary, adjustments were performed. The marginal fit of
no signs of active bone resorption or periapical pathology. the restorations was accepted, if the silicon indicator paste
Oral hygiene had to be good and caries activity low. showed a thin and homogeneous layer. No temporary
Maximum tooth mobility of grade 1 was accepted. Patients cementation of the FDPs was performed to avoid microcracks
with probing depths greater than 4 mm, vertical bone loss in the ceramic material.
around abutment tooth, extreme bruxism, limited vertical All restorations were cemented adhesively. The surfaces of
space for the required connector height of 4 mm or a the inlay retainers were etched with 5% hydrofluoric acid
conspicuous medical or psychological history were excluded (Ceramic etchant, Ivoclar Vivadent) for 20s and minimum 60s
from the study. silane coating (Monobond S, Ivoclar Vivadent). Then the FDPs
were bonded to the abutment teeth with standard luting
2.2. Clinicians techniques using a dentin adhesive (Syntac Classic, Ivoclar
Vivadent) and a bonding resin (Variolink II, Ivoclar Vivadent).
All clinical treatment of the patients included in this study Rubber dam protection was used during adhesive cementation
was performed by fifteen clinicians. The mean vocational procedures. After cementation, a radiograph of the restoration
experience of the clinicians was 2.9  1.0 years. The clinical and its abutment teeth was obtained.
treatment procedures were supervised and inspected by 2
dentists with a specialization in prosthodontics (approved by 2.4. Follow-up clinical examinations
the German Society for Prosthodontics and Dental Materials
[DGZPW]). To ensure homogeneity in treatment procedures One to three weeks after cementation patients were scheduled
during the study, all clinicians were calibrated considering the for a final evaluation. Follow-up examinations were per-
following treatment modalities. formed after 6 months, 12 months and then annually.
All patients who did not attend the follow-up examination
2.3. Prosthodontic procedures were contacted via telephone. They were asked two standard-
ized questions: (1) ‘‘Is the FDP still in situ?’’ and (2) ‘‘Do you
Inlay preparation procedures were performed in accordance have any problems with your teeth in general and especially
with the general principles for ceramic inlay restorations. with the FDP?’’
Abutment teeth were prepared with a mesial-occlusal, occlusal-
distal or mesio-occlusal-distal inlay cavity, respectively. Box- 2.5. Outcome
shaped inlay cavities were prepared with fine (30–40 mm grain)
diamond instruments under avoidance of any sharp angles. The According to Walton13, treatment outcomes were allocated to
finishing line was a shoulder, no bevels were used. In five cases, 1 of 6 fields:
there was a need for full crown preparation of one of the two Successful: Review of the documentation and patient
abutment teeth respectively. In these five cases, hybrid- examination revealed no evidence of or no need for retreat-
retained restorations (one abutment tooth with an inlay ment other than maintenance procedures, which include
retainer and one with a full crown retainer) were fabricated. prophylaxis and minor occlusal or contour adjustments.
After abutment preparation, impressions were taken with Surviving: The patient could not be examined directly, but the
a simultaneous, dual-mix technique using polyether material patient and the examination of the patients’ records confirmed
(Permadyne, 3M/ESPE, Seefeld, Germany). The impressions via telephone interview that there had been no retreatment
were cast with Type IV gypsum (GC-Fuji Rock EP, Tokyo, Japan) other than that described for a successful outcome.
and a die spacer was applied to each master die (Vita In-Ceram Unknown: The patient could not be traced or reached by
Distanzlack, Vita, Bad Säckingen, Germany). All FDPs were telephone.
made from a heat-pressed lithium-disilicate glass-ceramic Dead: The patient had passed away during the observation
(IPS e.max Press, Ivoclar Vivadent, Schaan, Liechtenstein) period. In these cases the FDPs were rated successful until
according to the manufacturers’ instructions. death.
For the fabrication of the FDPs, the wax patterns were Repaired: The original marginal integrity of all the retainers
fabricated and invested with a special investment material (IPS- and abutment teeth was maintained irrespective of other
Press Vest Speed, Ivoclar Vivadent). All FDPs were pressed in retreatments/modifications. Occlusal perforation of a retainer
one piece and no additional veneering was conducted. After the for access to perform endodontic therapy was not considered a
pressing process, minor adjustments to fit the castings to their repair.
dies were performed under a light microscope (magnification Failed: Any retainer or its marginal interface with its
20) if necessary. The use of additional veneering ceramic was respective abutment tooth had been lost.
only performed in cases where small corrections were neces- All types of failures that occurred during the observation
sary (i.e. pontic area, aesthetic form correction of the FDP). The time could be assigned to the following subcategories: (1) a
individualization of colour was achieved by using universal restoration had to be replaced because of the loss of retention
intensive stains (Universal Stains Kit, Ivoclar Vivadent). of one inlay retainer (Debonding I) or both inlay retainers
The minimum occlusal ceramic thickness for inlays and (Debonding II); a restoration had to be replaced because of
crowns was 1.5 mm. For the proximal connector the minimum fracture of one inlay retainer (Fracture I) or both inlay retainers
dimensions were 4 mm in height and 4 mm in width (16 mm2). (Fracture II) or because of fracture of the pontic (Fracture III) or
The marginal fit of the abutments was checked intraorally the combination of both, debonding and fracture of the inlay
with a silicon based indicator paste (Fit Checker, GC). If (Combined).
878 journal of dentistry 38 (2010) 875–881

Table 1 – Distribution by location of 40 inlay-retained and Table 2 – Outcome of FDPs (n = 45) after a mean
5 hybrid-retained fixed dental prostheses (FDPs). observation time of 70 months.
Location Type of FDP Outcome Type of FDP

Inlay-retained Hybrid-retained Inlay-retained Hybrid-retained Total

Right maxilla Successful 9 2 11


Second premolar 3 – Surviving 5 1 6
First molar 5 1 Unknown 1 – 1
Dead – – –
Left maxilla
Repaired – – –
Second premolar 1 –
Failed 25 2 27
First molar 12 1
FDP, fixed dental prosthesis.
Left mandible
Second premolar 1 –
First molar 8 1

Right mandible
months (minimum 4 months = first failure, maximum 123
Second premolar 1 2
months = last observation), 18 (40%) out of 45 FDPs were still in
First molar 9 –
situ, whereas the status of one inlay-retained FDP of one
FDP, fixed dental prosthesis. patient remained unknown after an observation period of 61
months. Last known status after clinical investigation of this
FDP was successful.
2.6. Statistical evaluation In four FDPs incorporated in 3 patients, biological problems
occurred (Table 3). In one case endodontic treatment of one
Kaplan–Meier’s survival curves14 were used to demonstrate abutment teeth was performed 17 months after cementation
cumulative survival rates and timing of FDPs. Survival time and, in the same patient, caries occurred at one abutment
was described by the distance between the date of cementa- tooth of another restoration 72 month after cementation. In
tion and the date of the last follow-up examination for the two other cases, caries occurred at one abutment teeth
categories: success, surviving and repaired. In case of failed respectively after 55 and 93 months after cementation. After
FDPs, survival time was described by the distance between the restorative therapy of the caries, all of these restorations are
date of cementation and the date of failure. For the dead and still in function.
unknown categories survival time was described between the The descriptive analysis of failures that occurred in 40 inlay-
date of cementation and the latest date of known status. retained and 5 hybrid-retained FDPs is shown in Table 4.
Twenty-seven (60%) out of 45 FDPs were lost during the
observation period. Eighteen out of 45 FDPs were lost because
3. Results of fractures (40%) and six because of debonding of one or two of
the inlay retainers (13%). In three cases (6%), the FDPs were lost
3.1. Patients because of a combination of fracture and debonding of the inlay
retainers. The two failures that occurred in the hybrid-retained
Forty-two patients were included in the study and gave their FDP group were fractures of one inlay retainer (Table 4).
written consent (21 women with a mean age of 36.1 years, The descriptive analysis of failures occurred in 40 inlay-
range 20–61 years; 21 men with a mean age of 42.0 years, range retained and 5 hybrid-retained FDPs related to the replaced
24–67 years). Altogether, 45 inlay-retained FDPs were inserted. tooth site is shown in Table 5. Eleven out of 18 fractures
The distribution of the replaced teeth is shown in Table 1. occurred in the mandible while 4 out of 6 FDPs were lost due to
debonding in the maxilla. All combined failures occurred in
3.2. Outcome of FDPs the maxilla.
The cumulative survival of the FDPs according to Kaplan–
Table 2 shows the distribution of all FDPs to the different Meier’s is demonstrated in Fig. 3. The five-year survival rate for
outcome categories. After a mean observation time of 70 inlay-retained FDPs was 57% (95% CI 42–75%) and 100% for

Table 3 – Descriptive analysis of biological problems that occurred in 40 inlay-retained and 5 hybrid-retained FDPs.
Patient Gender Replaced tooth Time to failure Failure mode Restoration type

1 M 26 55.4 mo Caries at 27; still in situ at 76 mo IR


2 M 36 93.5 mo Caries at 37; still in situ at 106 mo HY

3 F 35 17.2 mo Endo of 34; still in situ at 122 mo IR


45 72.4 mo Caries at 46; still in situ at 122 mo HY

F, female; M, male; IR, inlay-retained FDP; H, hybrid-retained FDP; mo, months.


Tooth numbers shown are FDI.
journal of dentistry 38 (2010) 875–881 879

Table 4 – Descriptive analysis of failures that occurred in 40 inlay-retained and 5 hybrid-retained FDPs.
Failure mode n

Fracture of one inlay retainer – (Fracture I) 13a


Fracture of both inlay retainers – (Fracture II) 3
Fracture of pontic area – (Fracture III) 2
Total fracture 18

Debonding of one inlay retainer – (Debonding I) 3


Debonding of both inlay retainers – (Debonding II) 3
Total debonding 6

Fracture and debonding of both inlay retainers – (Combined) 3b

Total 27

a
One out of 13 fixed dental prostheses (FDP) showing Fracture I failure mode was a hybrid-retained FDP.
b
One out of 3 fixed dental prostheses (FDP) showing Combined failure mode was a hybrid-retained FDP.

Table 5 – Descriptive analysis of failures that occurred in 40 inlay-retained and 5 hybrid-retained FDPs related to the
failure site.
Replaced teeth Failure mode Total

Fracture Debonding Combination: fracture No failure


and debonding

Maxilla 15 1 0 1 1 3
16 2 1 0 3 6
25 0 1 0 0 1
26 4 2 2 5 13

Mandible 35 0 0 0 1 1
36 5 0 0 4 9
45 1 0 0 2 3
46 5 2 0 2 9

Total 18 6 3 18 45

Tooth numbers shown are FDI.

hybrid-retained FDPs. After 8 years, the calculated survival outcome, as bonding to dentin is considerably less durable
rate was 38% (95% CI 16–54%) for inlay-retained FDPs and 60% than bonding to enamel.17 After losing retention in the
(95% CI 17–100%) for hybrid-retained FDPs. proximal inlay box mostly located in dentin, the stability of
the inlay retainer was limited to its fracture strength in the
small isthmus area of the inlay, which could withstand the
4. Discussion chewing forces (see Fig. 4). Most failures due to fracture or
debonding were related to FDPs replacing first molars and
The aim of the present prospective clinical study was to assess more fractures were observed in the mandible than in the
the outcome of three-unit inlay-retained FDPs made from maxilla (Table 5). This might be explained by the higher
lithium-disilicate ceramic. The results of the study showed a distortion of the mandible and the higher chewing stress
poor outcome of the investigated FDPs for the replacement of levels in the region of the first molar.
posterior premolars or molars after five and eight years, when To improve the outcome of inlay-retained all-ceramic FDPs
compared to the outcome of conventional crown-retained various suggestions regarding material and framework design
FDPs made from the same ceramic,15 which was comparable have been published.5,12,18,19 In vitro investigations regarding
to conventional metal-ceramic FDPs.16 different framework materials for inlay-retained FDPs showed
The failures of the inlay-retained FDPs were caused by a significant higher fracture strength of yttrium-oxide partially
fracture, debonding or a combination of debonding and stabilized zirconia ceramic compared to lithium-disilicate
fracture at the isthmus of one abutment, i.e. the connection heat-pressed ceramic as used in the present investigation.12,19
between the occlusal part and the proximal box of the inlay But first clinical attempts using zirconia frameworks for inlay-
(Fig. 4). High stresses at the adhesive interfaces when loading retained FDPs with an conventional inlay-retainer design
the pontics during chewing eccentrically10 might have been similar to our investigation showed also high clinical failure
responsible for the high fracture and debonding rate. In rates caused by debonding, fractures and chipping after a 12
addition to high torsion forces at the inlay retainers, the months observation period.5
relatively small area bonded to enamel and the big area A new framework design for inlay-retained FDPs made
bonded to dentin might be responsible for this intermediate from zirconia ceramic with oral retainer wings and shallow
880 journal of dentistry 38 (2010) 875–881
[(Fig._3)TD$IG]

Fig. 3 – Kaplan–Meier’s curve demonstrating the cumulative survival for inlay-retained (continuous line) and hybrid-

[(Fig._4)TD$IG]
retained (dotted line) FDPs.

Fig. 4 – Example of an inlay-retained FDP that failed due to debonding and fracture of the distal inlay retainer (asterisks). The
fracture of the distal retainer occurred at the intersection between the occlusal part and the proximal box of the inlay.
Bonding of the mesial retainer (arrow) was sufficient and the inlay was left in situ.

occlusal inlays was described by Wolfart et al. in 2006.18 In this maximizing the bonding area and minimizing torsion forces
design the framework material provides higher fracture on the inlay retainers when the FPDs are loaded nonaxially.
strength than lithium-disilicate ceramic and the extended Preliminary results indicate no clinical failures within the first
bonding surface in enamel minimizes the risk of debonding by two years.20
journal of dentistry 38 (2010) 875–881 881

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