00:00

metoprolol is a selective beta-1

00:02

adrenergic receptor blocker that acts by

00:05

blocking the effect of noradrenaline on

00:08

the beta 1 receptor on the cardiac

00:10

myocyte cell which consequently inhibits

00:14

adenylate cyclase activity that inhibits

00:16

cyclic GMP synthesis and consequently

00:19

the production of PK a leading to the

00:22

decrease in calcium influx through the

00:25

voltage-gated l-type calcium channel and

00:28

increase in potassium efflux thereby

00:32

decrease in the sympathetic effect on

00:34

the myocyte cell thus reducing heart

00:38

rate and contractility

00:39
moreover metoprolol on the SA nodal cell

00:44

blocks the effect of nor drillin on the

00:47

beatle one receptor decreasing the

00:50

effect of adenylate cyclase activity and

00:52

the production of PKA also decreasing

00:56

calcium influx and potassium efflux

00:59

thereby metropolis decreases the slope

01:02

of phase 4 in the nodal action potential

01:05

and prolongs the repolarization

01:07

of phase 3

Metoprolol - Mechanism of Action