T(min) Via intravenosa Via intramuscular Via subcutánea

0 0 0
5 144.20 59.88 16.07
15 54.78 72.66 39.14
30 67.56 118.67 16.07
60 34.35 54.77 75.04
90 26.68 47.11 34.02
120 13.91 41.99 31.45
Via intravenosa

AUC= (1/2)(144.20+54.78)(15-
INTRAVENOSA 5)=994.9
160 144.2 AUC= (1/2)(54.78+67.56)(30-
140 15)=917.55
120
AUC= (1/2)(67.56+34.35)(60-
100
30)=1528.65
80 67.56
54.78 AUC= (1/2)(34.35+26.68)(90-
60
34.35 60)=915.45
40 26.68
13.91 AUC= (1/2)(26.68+13.91)(120-
20
0
0
90)=608.85
0 20 40 60 80 100 120 140
AUC 0−120=4965.4

Ke= (2.63-4.21)/(120-30)=-0.02

ABC 13.91
120−¿= =695 .5¿
0.02

ABC 0−¿=4965.4 +695.5=5660 .9¿

T(min) Log concentración

5 2.16
15 1.74
30 1.83
60 1.54
90 1.43
120 1.14
Ŷ0= 2.03

102.03=107.15
ABC 107.15
0−¿= =5357.5¿
0.02

75 mg −¿ 1 Kg
195000µg
x=195 mg −¿2.6 Kg
Vd=195000/107.15=1819.88mL/1000=1.82 L

Cl=1.82*0.02=0.0364Lmin*1000=36.4 mLmin

ln 0.5
t 1/ 2= =34.66 h
0.02

Via intramuscular

AUC= (1/2)(0+59.88)(5-
INTRAMUSCULAR 0)=149.7
140 AUC= (1/2)(59.88+72.66)(15-
118.67
120 5)=662.7

100 AUC= (1/2)(72.66+118.67)(30-

15)=1434.97
80 72.66
59.8 AUC= (1/2)(118.67+54.77)(60-
54.77
60 47.11
41.99 30)=2601.6
40
AUC= (1/2)(54.77+47.11)(90-
20 60)=1528.2
0
0 AUC= (1/2)(47.11+41.99)(120-
0 20 40 60 80 100 120 140
90)=1336.5

AUC 0−120=7713.67

Ke= (3.74-4.78)/(120-30)=-0.01

ABC 41.99
120−¿= =4199¿
0.01

ABC 0−¿=7713.67+4199=11912.67¿

F
|¿|=
( 11912.67
5660.9 )
∗100=210.4 3 %¿

SUBCUTANEA Via subcutánea

80 75.04
AUC= (1/2)(0+16.07)(5-
70 0)=40.17
60
AUC= (1/2)(16.07+39.14)(15-
50 5)=276.05
39.14
40 34.02
31.45
30

20 16.07 16.07

10
0
0
0 20 40 60 80 100 120 140
AUC= (1/2)(39.14+16.07)(30-15)=414.07

AUC= (1/2)(16.07+75.04)(60-30)=1366.65

AUC= (1/2)(75.04+34.02)(90-60)=1635.9

AUC= (1/2)(34.02+31.45)(120-90)=982.05

AUC 0−120=4714.8

Ke= (3.45-2.78)/(120-30)=0.007

ABC 31.45
120−¿= =4492.86¿
0.007

ABC 0−¿=4714.9+ 4492.86=9207.76¿

F
( 9207.76
|¿|=
5660.9 )
∗100=162.65% ¿